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1. Euclid preparation: TBD. The pre-launch Science Ground Segment simulation framework

Author

Euclid Collaboration, Serrano, S., Hudelot, P., Seidel, G., Pollack, J. E., Jullo, E., Torradeflot, F., Benielli, D., Fahed, R., Auphan, T., Carretero, J., Aussel, H., Casenove, P., Castander, F. J., Davies, J. E., Fourmanoit, N., Huot, S., Kara, A., Keihanen, E., Kermiche, S., Okumura, K., Zoubian, J., Ealet, A., Boucaud, A., Bretonniere, H., Casas, R., Clement, B., Duncan, C. A. J., George, K., Kiiveri, K., Kurki-Suonio, H., Kummel, M., Laugier, D., Mainetti, G., Mohr, J. J., Montoro, A., Neissner, C., Schirmer, M., Tallada-Crespi, P., Tonello, N., Venhola, A., Verderi, A., Zacchei, A., Aghanim, N., Altieri, B., Amara, A., Andreon, S., Auricchio, N., Azzollini, R., Baldi, M., Bardelli, S., Basset, A., Battaglia, P., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Candini, G. P., Capobianco, V., Carbone, C., Casas, S., Castellano, M., Cavuoti, S., Cimatti, A., Cledassou, R., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Courtois, H. M., Cropper, M., Da Silva, A., Degaudenzi, H., Di Giorgio, A. M., Dinis, J., Dubath, F., Dupac, X., Dusini, S., Farina, M., Farrens, S., Ferriol, S., Frailis, M., Franceschi, E., Franzetti, P., Galeotta, S., Garilli, B., Gillard, W., Gillis, B., Giocoli, C., Granett, B. R., Grazian, A., Grupp, F., Guzzo, L., Haugan, S. V. H., Hoar, J., Hoekstra, H., Holmes, W., Hook, I., Hormuth, F., Hornstrup, A., Jahnke, K., Joachimi, B., Kiessling, A., Kitching, T., Kohley, R., Kunz, M., Boulc'h, Q. Le, Ligori, S., Lilje, P. B., Lindholm, V., Lloro, I., Maino, D., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinet, N., Marulli, F., Massey, R., Maurogordato, S., Medinaceli, E., Mei, S., Melchior, M., Mellier, Y., Meneghetti, M., Merlin, E., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Nakajima, R., Niemi, S. -M., Nutma, T., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Pozzetti, L., Raison, F., Rebolo, R., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Rossetti, E., Saglia, R., Sapone, D., Sartoris, B., Sauvage, M., Schneider, P., Schrabback, T., Scodeggio, M., Secroun, A., Sirignano, C., Sirri, G., Skottfelt, J., Stanco, L., Starck, J. -L., Taylor, A. N, Teplitz, H., Tereno, I., Toledo-Moreo, R., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Veropalumbo, A., Wang, Y., Weller, J., Zamorani, G., Zucca, E., Biviano, A., Bozzo, E., Colodro-Conde, C., Di Ferdinando, D., Farinelli, R., Gracia-Carpio, J., Liebing, P., Marcin, S., Mauri, N., Scottez, V., Tenti, M., Akrami, Y., Allevato, V., Baccigalupi, C., Ballardini, M., Bernardeau, F., Blanchard, A., Borgani, S., Borlaff, A. S., Bruton, S., Burigana, C., Cappi, A., Carvalho, C. S., Castignani, G., Castro, T., Canas-Herrera, G., Chambers, K. C., Cooray, A. R., Coupon, J., Crocce, M., Davini, S., de la Torre, S., De Lucia, G., Desai, S., Desprez, G., Diaz-Sanchez, A., Di Domizio, S., Dole, H., Vigo, J. A. Escartin, Escoffier, S., Ferrero, I., Finelli, F., Gabarra, L., Ganga, K., Garcia-Bellido, J., Gaztanaga, E., Giacomini, F., Gozaliasl, G., Gregorio, A., Hildebrandt, H., Huertas-Company, M., Ilbert, O., Munoz, A. Jimenez, Kajava, J. J. E., Kansal, V., Kirkpatrick, C. C., Legrand, L., Loureiro, A., Macias-Perez, J., Magliocchetti, M., Maoli, R., Martinelli, M., Martins, C. J. A. P., Matthew, S., Maurin, L., Metcalf, R. B., Migliaccio, M., Monaco, P., Morgante, G., Morris, P., Nadathur, S., Nucita, A. A., Pontinen, M., Popa, V., Porciani, C., Potter, D., Reimberg, P., Rusholme, B., Sakr, Z., Sanchez, A. G., Schneider, A., Sereno, M., Shulevski, A., Simon, P., Mancini, A. Spurio, Stadel, J., Steinwagner, J., Tewes, M., Teyssier, R., Toft, S., Tucci, M., Valiviita, J., Viel, M., and Zinchenko, I. A.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The European Space Agency's Euclid mission is one of the upcoming generation of large-scale cosmology surveys, which will map the large-scale structure in the Universe with unprecedented precision. The development and validation of the SGS pipeline requires state-of-the-art simulations with a high level of complexity and accuracy that include subtle instrumental features not accounted for previously as well as faster algorithms for the large-scale production of the expected Euclid data products. In this paper, we present the Euclid SGS simulation framework as applied in a large-scale end-to-end simulation exercise named Science Challenge 8. Our simulation pipeline enables the swift production of detailed image simulations for the construction and validation of the Euclid mission during its qualification phase and will serve as a reference throughout operations. Our end-to-end simulation framework starts with the production of a large cosmological N-body & mock galaxy catalogue simulation. We perform a selection of galaxies down to I_E=26 and 28 mag, respectively, for a Euclid Wide Survey spanning 165 deg^2 and a 1 deg^2 Euclid Deep Survey. We build realistic stellar density catalogues containing Milky Way-like stars down to H<26. Using the latest instrumental models for both the Euclid instruments and spacecraft as well as Euclid-like observing sequences, we emulate with high fidelity Euclid satellite imaging throughout the mission's lifetime. We present the SC8 data set consisting of overlapping visible and near-infrared Euclid Wide Survey and Euclid Deep Survey imaging and low-resolution spectroscopy along with ground-based. This extensive data set enables end-to-end testing of the entire ground segment data reduction and science analysis pipeline as well as the Euclid mission infrastructure, paving the way to future scientific and technical developments and enhancements., Comment: 38 pages, 25 figures, A&A submitted

Published
2024

2. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., de Queiroz, J.P., Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, and Hill, Michael D

Published
2024
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5. Spectroscopic variability of two Oe stars

Author

Rauw, G., Morel, T., Naze, Y., Eversberg, T., Alves, F., Arnold, W., Bergmann, T., Viegas, N. G. Correia, Fahed, R., Fernando, A., Gonzalez-Perez, J. N., Carreira, L. F. Gouveia, Hempelmann, A., Hunger, T., Knapen, J. H., Leadbeater, R., Dias, F. Marques, Mittag, M., Moffat, A. F. J., Reinecke, N., Ribeiro, J., Romeo, N., Gallego, J. Sanchez, Santos, E. M. Dos, Schanne, L., Schmitt, J. H. M. M., Schroeder, K. -P., Stahl, O., Stober, Ba., Stober, Be., and Vollmann, K.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The Oe stars HD45314 and HD60848 have recently been found to exhibit very different X-ray properties: whilst HD60848 has an X-ray spectrum and emission level typical of most OB stars, HD45314 features a much harder and brighter X-ray emission, making it a so-called gamma Cas analogue. Monitoring the optical spectra could provide hints towards the origin of these very different behaviours. We analyse a large set of spectroscopic observations of HD45314 and HD60848, extending over 20 years. We further attempt to fit the H-alpha line profiles of both stars with a simple model of emission line formation in a Keplerian disk. Strong variations in the strengths of the H-alpha, H-beta, and He I 5876 emission lines are observed for both stars. In the case of HD60848, we find a time lag between the variations in the equivalent widths of these lines. The emission lines are double peaked with nearly identical strengths of the violet and red peaks. The H-alpha profile of this star can be successfully reproduced by our model of a disk seen under an inclination of 30 degrees. In the case of HD45314, the emission lines are highly asymmetric and display strong line profile variations. We find a major change in behaviour between the 2002 outburst and the one observed in 2013. This concerns both the relationship between the equivalent widths of the various lines and their morphologies at maximum strength (double-peaked in 2002 versus single-peaked in 2013). Our simple disk model fails to reproduce the observed H-alpha line profiles of HD45314. Our results further support the interpretation that Oe stars do have decretion disks similar to those of Be stars. Whilst the emission lines of HD60848 are explained by a disk with a Keplerian velocity field, the disk of HD45314 seems to have a significantly more complex velocity field that could be related to the phenomenon that produces its peculiar X-ray emission., Comment: Accepted for Publication in A&A

Published
2015
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7. A randomized trial of endovascular versus surgical management of ruptured intracranial aneurysms: Interim results from ISAT2

Author

Darsaut, T.E., Roy, D., Weill, A., Bojanowski, M.W., Chaalala, C., Bilocq, A., Findlay, J.M., Rempel, J.L., Chow, M.M., O’Kelly, C., Ashforth, R.A., Kotowski, M., Magro, E., Lemus, M., Fahed, R., Arikan, F., Arrese, I., Sarabia, R., Altschul, D.J., Chagnon, M., Guilbert, F., Shankar, J.J.S., Proust, F., Nolet, S., Gevry, G., and Raymond, J.

Published
2019
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9. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kenney, Carol, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, Hill, Michael D, Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Chen, S., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Cooley, R., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Irons, R., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Biswas, V., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Kerr, E., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Patel, V., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Aissa, M., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., Ismail, M., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., and de Queiroz, J.P.

Abstract

Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.

Published
2024
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10. WR 110: A Single Wolf-Rayet Star With Corotating Interaction Regions In Its Wind?

Author

Chené, A. -N., Moffat, A. F. J., Cameron, C., Fahed, R., Gamen, R. C., Lefèvre, L., Rowe, J. F., St-Louis, N., Muntean, V., De La Chevrotière, A., Guenther, D. B., Kuschnig, R., Matthews, J. M., Rucinski, S. M., Sasselov, D., and Weiss, W. W.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

A 30-day contiguous photometric run with the MOST satellite on the WN5-6b star WR 110 (HD 165688) reveals a fundamental periodicity of P = 4.08 +/- 0.55 days along with a number of harmonics at periods P/n, with n ~ 2,3,4,5 and 6, and a few other possible stray periodicities and/or stochastic variability on timescales longer than about a day. Spectroscopic RV studies fail to reveal any plausible companion with a period in this range. Therefore, we conjecture that the observed light-curve cusps of amplitude ~ 0.01 mag that recur at a 4.08 day timescale may arise in the inner parts, or at the base of, a corotating interaction region (CIR) seen in emission as it rotates around with the star at constant angular velocity. The hard X-ray component seen in WR 110 could then be a result of a high velocity component of the CIR shock interacting with the ambient wind at several stellar radii. Given that most hot, luminous stars showing CIRs have two CIR arms, it is possible that either the fundamental period is 8.2 days or, more likely in the case of WR 110, there is indeed a second weaker CIR arm for P = 4.08 days, that occurs ~ two thirds of a rotation period after the main CIR. If this interpretation is correct, WR 110 therefore joins the ranks with three other single WR stars, all WN, with confirmed CIR rotation periods (WR 1, WR 6, and WR 134), albeit with WR 110 having by far the lowest amplitude photometric modulation. This illustrates the power of being able to secure intense, continuous high-precision photometry from space-based platforms such as MOST. It also opens the door to revealing low-amplitude photometric variations in other WN stars, where previous attempts have failed. If all WN stars have CIRs at some level, this could be important for revealing sources of magnetism or pulsation in addition to rotation periods., Comment: 25 pages, 8 figures, 2 tables, accepted in ApJ

Published
2011
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11. The WR 140 periastron passage 2009: first results from MONS and other optical sources

Author

Fahed, R., Moffat, A. F. J., Zorec, J., Eversberg, T., Chené, A. N., Alves, F., Arnold, W., Bergmann, T., Carreira, L. F. Gouveia, Dias, F. Marques, Fernando, A., Gallego, J. Sanchez, Hunger, T., Knapen, J. H., Leadbeater, R., Morel, T., Rauw, G., Reinecke, N., Ribeiro, J., Romeo, N., Santos, E. M. dos, Schanne, L., Stahl, O., Stober, Ba., Stober, Be., Viegas, N. G. Correia, Vollmann, K., Corcoran, M. F., Dougherty, S. M., Pittard, J. M., Pollock, A. M. T., and Williams, P. M.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present the results from the spectroscopic follow-up of WR140 (WC7 + O4-5) during its last periastron passage in January 2009. This object is known as the archetype of colliding wind binaries and has a relatively large period (~ 8 years) and eccentricity (~ 0.89). We provide updated values for the orbital parameters, new estimates for the WR and O star masses and new constraints on the mass-loss rates., Comment: 5 pages, 5 figures, Published in proceedings of "Stellar Winds in Interaction", editors T. Eversberg and J.H. Knapen. Full proceedings volume is available on http://www.stsci.de/pdf/arrabida.pdf

Published
2011

12. Variability monitoring of OB stars during the Mons campaign

Author

Morel, T., Rauw, G., Eversberg, T., Alves, F., Arnold, W., Bergmann, T., Viegas, N. G. Correia, Fahed, R., Fernando, A., Carreira, L. F. Gouveia, Hunger, T., Knapen, J. H., Leadbeater, R., Dias, F. Marques, Moffat, A. F. J., Reinecke, N., Ribeiro, J., Romeo, N., Gallego, J. Sanchez, Santos, E. M. dos, Schanne, L., Stahl, O., Stober, Ba., Stober, Be., Vollmann, K., Corcoran, M. F., Dougherty, S. M., Hamaguchi, K., Pittard, J. M., Pollock, A. M. T., and Williams, P. M.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present preliminary results of a 3-month campaign carried out in the framework of the Mons project, where time-resolved Halpha observations are used to study the wind and circumstellar properties of a number of OB stars., Comment: 2 pages, 1 figure. To appear in proceedings of IAUS272 'Active OB Stars: Structure, Evolution, Mass Loss and Critical Limits'

Published
2010
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14. Photometric variability of WC9 stars

Author

Fahed, R., Moffat, A. F. J., and Bonanos, A. Z.

Subjects
Astrophysics
Abstract

Do some Wolf-Rayet stars owe their strong winds to something else besides radiation pressure? The answer to this question is still not entirely obvious, especially in certain Wolf-Rayet subclasses, mainly WN8 and WC9. Both of these types of Wolf-Rayet stars are thought to be highly variable, as suggested by observations, possibly due to pulsations. However, only the WN8 stars have so far been vigorously and systematically investigated for variability. We present here the results of a systematic survey during 3 consecutive weeks of 19 Galactic WC9 stars and 1 WC8 star for photometric variability in two optical bands, V and I. Of particular interest are the correlated variations in brightness and colour index in the context of carbon-dust formation, which occurs frequently in WC9 and some WC8 stars. In the most variable case, WR76, we used this information to derive a typical dust grain size of ~ 0.1 um. However, most photometric variations occur at surprisingly low levels and in fact almost half of our sample shows no significant variability at all above the instrumental level (sigma ~ 0.005 - 0.01 mag)., Comment: 7 pages, 7 figures, 1 table, AMStex

Published
2008
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16. Stent-Assisted Coiling in the Treatment of Unruptured Intracranial Aneurysms: A Randomized Clinical Trial

Author

Boisseau, W., primary, Darsaut, T.E., additional, Fahed, R., additional, Drake, B., additional, Lesiuk, H., additional, Rempel, J.L., additional, Gentric, J.-C., additional, Ognard, J., additional, Nico, L., additional, Iancu, D., additional, Roy, D., additional, Weill, A., additional, Chagnon, M., additional, Zehr, J., additional, Lavoie, P., additional, Nguyen, T.N., additional, and Raymond, J., additional

Published
2023
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18. General anesthesia or conscious sedation for endovascular therapy of basilar artery occlusions: ETIS registry results

Author

Skutecki, J., primary, Audibert, G., additional, Finitsis, S., additional, Consoli, A., additional, Lapergue, B., additional, Blanc, R., additional, Bourcier, R., additional, Sibon, I., additional, Eugène, F., additional, Vannier, S., additional, Dargazanli, C., additional, Arquizan, C., additional, Anxionnat, R., additional, Richard, S., additional, Fahed, R., additional, Marnat, G., additional, and Gory, B., additional

Published
2022
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19. Surgical or Endovascular Treatment of MCA Aneurysms: An Agreement Study

Author

Boisseau, W., primary, Darsaut, T.E., additional, Fahed, R., additional, Findlay, J.M., additional, Bourcier, R., additional, Charbonnier, G., additional, Smajda, S., additional, Ognard, J., additional, Roy, D., additional, Gariel, F., additional, Carlson, A.P., additional, Shotar, E., additional, Ciccio, G., additional, Marnat, G., additional, Sporns, P.B., additional, Gaberel, T., additional, Jecko, V., additional, Weill, A., additional, Biondi, A., additional, Boulouis, G., additional, Bras, A.L., additional, Aldea, S., additional, Passeri, T., additional, Boissonneau, S., additional, Bougaci, N., additional, Gentric, J.C., additional, Diestro, J.D.B., additional, Omar, A.T., additional, Al-Jehani, H.M., additional, Hage, G. El, additional, Volders, D., additional, Kaderali, Z., additional, Tsogkas, I., additional, Magro, E., additional, Holay, Q., additional, Zehr, J., additional, Iancu, D., additional, and Raymond, J., additional

Published
2022
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20. P.113 Time metrics and clinical outcomes of thrombectomy in acute stroke patients before and after implementation of COVID-19 infection protocols in six Canadian stroke centres

Author

Zhu, S, primary, Tsehmaister-Abitbul, V, additional, Stotts, G, additional, Fahed, R, additional, Pettem, H, additional, Guy, U, additional, Aviv, R, additional, Agid, R, additional, Pikula, A, additional, Shankar, J, additional, Milot, G, additional, Van Adel, B, additional, Yip, S, additional, Settecase, F, additional, and dos Santos, M, additional

Published
2022
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24. Erratum to: «Improved detection and characterization of arterial occlusion in acute ischemic stroke using Contrast Enhanced MRA» [J Neuroradiol 2020;47(4):278–283]

Author

Dhundass, Sarah, primary, Savatovsky, Julien, additional, Duron, Loïc, additional, Fahed, R., additional, Escalard, Simon, additional, Obadia, Michael, additional, Zuber, Kevin, additional, Metten, Marie Astrid, additional, Mejdoubi, Mehdi, additional, Blanc, Raphaël, additional, Sadik, Jean-Claude, additional, Collin, Adrien, additional, and Lecler, Augustin, additional

Published
2021
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25. C.1 Time Metrics and Clinical Outcomes of Thrombectomy in Acute Stroke Patients Before and After Implementation of COVID-19 Infection Protocols in Nine Canadian Stroke Centres

Author

Zhu, S, primary, Tsehmaister-Abitbul, V, additional, Stotts, G, additional, Fahed, R, additional, Pettem, H, additional, Aviv, R, additional, Agid, R, additional, Pikula, A, additional, Shankar, J, additional, Milot, G, additional, Peeling, L, additional, Tampieri, D, additional, Pandey, S, additional, Leite, L, additional, Catanese, L, additional, Van Adel, B, additional, Yip, S, additional, Settecase, F, additional, and dos Santos, M, additional

Published
2021
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27. Noninvasive Angiographic Results of Clipped or Coiled Intracranial Aneurysms: An Inter- and Intraobserver Reliability Study

Author

Benomar, A., primary, Farzin, B., additional, Gevry, G., additional, Boisseau, W., additional, Roy, D., additional, Weill, A., additional, Iancu, D., additional, Guilbert, F., additional, Létourneau-Guillon, L., additional, Jacquin, G., additional, Chaalala, C., additional, Bojanowski, M.W., additional, Labidi, M., additional, Fahed, R., additional, Volders, D., additional, Nguyen, T.N., additional, Gentric, J.-C., additional, Magro, E., additional, Boulouis, G., additional, Forestier, G., additional, Hak, J.-F., additional, Ghostine, J.S., additional, Kaderali, Z., additional, Shankar, J.J., additional, Kotowski, M., additional, Darsaut, T.E., additional, and Raymond, J., additional

Published
2021
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29. Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic

Author

Nguyen, T.N. Haussen, D.C. Qureshi, M.M. Yamagami, H. Fujinaka, T. Mansour, O.Y. Abdalkader, M. Frankel, M. Qiu, Z. Taylor, A. Lylyk, P. Eker, O.F. Mechtouff, L. Piotin, M. Lima, F.O. Mont'Alverne, F. Izzath, W. Sakai, N. Mohammaden, M. Al-Bayati, A.R. Renieri, L. Mangiafico, S. Ozretic, D. Chalumeau, V. Ahmad, S. Rashid, U. Hussain, S.I. John, S. Griffin, E. Thornton, J. Fiorot, J.A. Rivera, R. Hammami, N. Cervantes-Arslanian, A.M. Dasenbrock, H.H. Vu, H.L. Nguyen, V.Q. Hetts, S. Bourcier, R. Guile, R. Walker, M. Sharma, M. Frei, D. Jabbour, P. Herial, N. Al-Mufti, F. Ozdemir, A.O. Aykac, O. Gandhi, D. Chugh, C. Matouk, C. Lavoie, P. Edgell, R. Beer-Furlan, A. Chen, M. Killer-Oberpfalzer, M. Pereira, V.M. Nicholson, P. Huded, V. Ohara, N. Watanabe, D. Shin, D.H. Magalhaes, P.S.C. Kikano, R. Ortega-Gutierrez, S. Farooqui, M. Abou-Hamden, A. Amano, T. Yamamoto, R. Weeks, A. Cora, E.A. Sivan-Hoffmann, R. Crosa, R. Möhlenbruch, M. Nagel, S. Al-Jehani, H. Sheth, S.A. Rivera, V.S.L. Siegler, J.E. Sani, A.F. Puri, A.S. Kuhn, A.L. Bernava, G. Machi, P. Abud, D.G. Pontes-Neto, O.M. Wakhloo, A.K. Voetsch, B. Raz, E. Yaghi, S. Mehta, B.P. Kimura, N. Murakami, M. Lee, J.S. Hong, J.M. Fahed, R. Walker, G. Hagashi, E. Cordina, S.M. Roh, H.G. Wong, K. Arenillas, J.F. Martinez-Galdamez, M. Blasco, J. Vasquez, A.R. Fonseca, L. Silva, M.L. Wu, T.Y. John, S. Brehm, A. Psychogios, M. Mack, W.J. Tenser, M. Todaka, T. Fujimura, M. Novakovic, R. Deguchi, J. Sugiura, Y. Tokimura, H. Khatri, R. Kelly, M. Peeling, L. Murayama, Y. Winters, H.S. Wong, J. Teleb, M. Payne, J. Fukuda, H. Miyake, K. Shimbo, J. Sugimura, Y. Uno, M. Takenobu, Y. Matsumaru, Y. Yamada, S. Kono, R. Kanamaru, T. Morimoto, M. Iida, J. Saini, V. Yavagal, D. Bushnaq, S. Huang, W. Linfante, I. Kirmani, J. Liebeskind, D.S. Szeder, V. Shah, R. Devlin, T.G. Birnbaum, L. Luo, J. Churojana, A. Masoud, H.E. Lopez, C.Y. Steinfort, B. Ma, A. Hassan, A.E. Al Hashmi, A. McDermott, M. Mokin, M. Chebl, A. Kargiotis, O. Tsivgoulis, G. Morris, J.G. Eskey, C.J. Thon, J. Rebello, L. Altschul, D. Cornett, O. Singh, V. Pandian, J. Kulkarni, A. Lavados, P.M. Olavarria, V.V. Todo, K. Yamamoto, Y. Silva, G.S. Geyik, S. Johann, J. Multani, S. Kaliaev, A. Sonoda, K. Hashimoto, H. Alhazzani, A. Chung, D.Y. Mayer, S.A. Fifi, J.T. Hill, M.D. Zhang, H. Yuan, Z. Shang, X. Castonguay, A.C. Gupta, R. Jovin, T.G. Raymond, J. Zaidat, O.O. Nogueira, R.G.

Subjects
cardiovascular diseases, nervous system diseases
Abstract

Background During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines. Methods We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before (1 year and immediately before) and during the pandemic, defined as 1 March-31 May 2020. The prior 1-year control period (1 March-31 May 2019) was obtained to account for seasonal variation. Findings There was a significant decline in SAH hospitalisations, with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic, representing a relative decline of 22.5% (95% CI -24.3% to -20.7%, p

Published
2021

30. Global impact of COVID-19 on stroke care

Author

Nogueira, R.G. Abdalkader, M. Qureshi, M.M. Frankel, M.R. Mansour, O.Y. Yamagami, H. Qiu, Z. Farhoudi, M. Siegler, J.E. Yaghi, S. Raz, E. Sakai, N. Ohara, N. Piotin, M. Mechtouff, L. Eker, O. Chalumeau, V. Kleinig, T.J. Pop, R. Liu, J. Winters, H.S. Shang, X. Vasquez, A.R. Blasco, J. Arenillas, J.F. Martinez-Galdamez, M. Brehm, A. Psychogios, M.-N. Lylyk, P. Haussen, D.C. Al-Bayati, A.R. Mohammaden, M.H. Fonseca, L. Luís Silva, M. Montalverne, F. Renieri, L. Mangiafico, S. Fischer, U. Gralla, J. Frei, D. Chugh, C. Mehta, B.P. Nagel, S. Mohlenbruch, M. Ortega-Gutierrez, S. Farooqui, M. Hassan, A.E. Taylor, A. Lapergue, B. Consoli, A. Campbell, B.C.V. Sharma, M. Walker, M. Van Horn, N. Fiehler, J. Nguyen, H.T. Nguyen, Q.T. Watanabe, D. Zhang, H. Le, H.V. Nguyen, V.Q. Shah, R. Devlin, T. Khandelwal, P. Linfante, I. Izzath, W. Lavados, P.M. Olavarría, V.V. Sampaio Silva, G. de Carvalho Sousa, A.V. Kirmani, J. Bendszus, M. Amano, T. Yamamoto, R. Doijiri, R. Tokuda, N. Yamada, T. Terasaki, T. Yazawa, Y. Morris, J.G. Griffin, E. Thornton, J. Lavoie, P. Matouk, C. Hill, M.D. Demchuk, A.M. Killer-Oberpfalzer, M. Nahab, F. Altschul, D. Ramos-Pachón, A. Pérez de la Ossa, N. Kikano, R. Boisseau, W. Walker, G. Cordina, S.M. Puri, A. Luisa Kuhn, A. Gandhi, D. Ramakrishnan, P. Novakovic-White, R. Chebl, A. Kargiotis, O. Czap, A. Zha, A. Masoud, H.E. Lopez, C. Ozretic, D. Al-Mufti, F. Zie, W. Duan, Z. Yuan, Z. Huang, W. Hao, Y. Luo, J. Kalousek, V. Bourcier, R. Guile, R. Hetts, S. Al-Jehani, H.M. AlHazzani, A. Sadeghi-Hokmabadi, E. Teleb, M. Payne, J. Lee, J.S. Hong, J.M. Sohn, S.-I. Hwang, Y.-H. Shin, D.H. Roh, H.G. Edgell, R. Khatri, R. Smith, A. Malik, A. Liebeskind, D. Herial, N. Jabbour, P. Magalhaes, P. Ozdemir, A.O. Aykac, O. Uwatoko, T. Dembo, T. Shimizu, H. Sugiura, Y. Miyashita, F. Fukuda, H. Miyake, K. Shimbo, J. Sugimura, Y. Beer-Furlan, A. Joshi, K. Catanese, L. Abud, D.G. Neto, O.G. Mehrpour, M. Al Hashmi, A. Saqqur, M. Mostafa, A. Fifi, J.T. Hussain, S. John, S. Gupta, R. Sivan-Hoffmann, R. Reznik, A. Sani, A.F. Geyik, S. Akıl, E. Churojana, A. Ghoreishi, A. Saadatnia, M. Sharifipour, E. Ma, A. Faulder, K. Wu, T. Leung, L. Malek, A. Voetsch, B. Wakhloo, A. Rivera, R. Barrientos Iman, D.M. Pikula, A. Lioutas, V.-A. Thomalla, G. Birnbaum, L. Machi, P. Bernava, G. McDermott, M. Kleindorfer, D. Wong, K. Patterson, M.S. Fiorot, J.A., Jr. Huded, V. Mack, W. Tenser, M. Eskey, C. Multani, S. Kelly, M. Janardhan, V. Cornett, O. Singh, V. Murayama, Y. Mokin, M. Yang, P. Zhang, X. Yin, C. Han, H. Peng, Y. Chen, W. Crosa, R. Frudit, M.E. Pandian, J.D. Kulkarni, A. Yagita, Y. Takenobu, Y. Matsumaru, Y. Yamada, S. Kono, R. Kanamaru, T. Yamazaki, H. Sakaguchi, M. Todo, K. Yamamoto, N. Sonoda, K. Yoshida, T. Hashimoto, H. Nakahara, I. Cora, E. Volders, D. Ducroux, C. Shoamanesh, A. Ospel, J. Kaliaev, A. Ahmed, S. Rashid, U. Rebello, L.C. Pereira, V.M. Fahed, R. Chen, M. Sheth, S.A. Palaiodimou, L. Tsivgoulis, G. Chandra, R. Koyfman, F. Leung, T. Khosravani, H. Dharmadhikari, S. Frisullo, G. Calabresi, P. Tsiskaridze, A. Lobjanidze, N. Grigoryan, M. Czlonkowska, A. de Sousa, D.A. Demeestere, J. Liang, C. Sangha, N. Lutsep, H.L. Ayo-Martín, Ó. Cruz-Culebras, A. Tran, A.D. Young, C.Y. Cordonnier, C. Caparros, F. De Lecinana, M.A. Fuentes, B. Yavagal, D. Jovin, T. Spelle, L. Moret, J. Khatri, P. Zaidat, O. Raymond, J. Martins, S. Nguyen, T.

Abstract

Background: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March–31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, −19.7 to −18.7), 11.5% (95%CI, −12.6 to −10.6), and 12.7% (95%CI, −13.6 to −11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (−20.5%) had greater declines in mechanical thrombectomy volumes than mid- (−10.1%) and low-volume (−8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes. © 2021 World Stroke Organization.

Published
2021

31. Delayed Contrast-Enhanced MR Angiography for the Assessment of Internal Carotid Bulb Patency in the Context of Acute Ischemic Stroke: An Accuracy, Interrater, and Intrarater Agreement Study

Author

Boisseau, W., primary, Benaissa, A., additional, Fahed, R., additional, Amegnizin, J.-L., additional, Smajda, S., additional, Benadjaoud, S., additional, Benadjaoud, A.M., additional, Saint-Val, L., additional, Alias, Q., additional, Iorio, P., additional, Yang, S., additional, Zuber, K., additional, Kalsoum, E., additional, and Hodel, J., additional

Published
2021
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32. Reliability of the Diagnosis of Cerebral Vasospasm Using Catheter Cerebral Angiography: A Systematic Review and Inter- and Intraobserver Study

Author

Darsaut, T.E., primary, Derksen, C., additional, Farzin, B., additional, Keough, M.B., additional, Fahed, R., additional, Boisseau, W., additional, Letourneau-Guillon, L., additional, Januel, A.-C., additional, Weill, A., additional, Roy, D., additional, Nguyen, T.N., additional, Finitsis, S., additional, Gentric, J.-C., additional, Volders, D., additional, Carlson, A., additional, Chow, M.M., additional, O’Kelly, C., additional, Rempel, J.L., additional, Ashforth, R.A., additional, Chagnon, M., additional, Zehr, J., additional, Findlay, J.M., additional, Gevry, G., additional, and Raymond, J., additional

Published
2021
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33. Mechanical thrombectomy practices in France: Exhaustive survey of centers and individual operators

Author

Forestier, Géraud, primary, Kerleroux, Basile, additional, Janot, Kévin, additional, Zhu, François, additional, Dumas, Victor, additional, Hak, Jean-François, additional, Shotar, Eimad, additional, Ben Hassen, Wagih, additional, Bourcier, Romain, additional, Soize, Sébastien, additional, Berge, Jérome, additional, Naggara, Olivier, additional, Desal, Hubert, additional, Boulouis, Grégoire, additional, Rouchaud, Aymeric, additional, Hanafi, R., additional, L’Allinec, V., additional, Girot, J.-B., additional, Charbonnier, G., additional, Biondi, A., additional, Gariel, F., additional, Marnat, G., additional, Ognard, J., additional, Gentric, J.-C., additional, Barbier, C., additional, Chabert, E., additional, Lebedinsky, P., additional, Tuilier, T., additional, Thouant, P., additional, Comby, P.-O., additional, Mejdoubi, M., additional, Heck, O., additional, Kastler, A., additional, Chalumeau, V., additional, Caroff, J., additional, Personnic, T., additional, Marchal, A., additional, Bogey, C., additional, Eker, O., additional, Carle, X., additional, Dargazanli, C., additional, Derraz, I., additional, Gory, B., additional, Detraz, L., additional, Sedat, J., additional, Zurlinden, O., additional, Escalard, S., additional, Fahed, R., additional, Guedon, A., additional, Civelli, V., additional, Premat, K., additional, Clarençon, F., additional, Ducouret, E., additional, Raynaud, N., additional, Velasco, S., additional, Manceau, P.-F., additional, Paya, C., additional, Eugene, F., additional, Le Moa, J., additional, Papagiannaki, C., additional, Aggour, M., additional, Bintner, M., additional, Veyrieres, J.-B., additional, Richter, J.S., additional, Pop, R., additional, Consoli, A., additional, Di-Maria, F., additional, Arteaga, C., additional, Darcourt, J., additional, Michelozzi, C., additional, Guedin, P., additional, Herbreteau, D., additional, and Le Bras, A., additional

Published
2020
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35. Fusion Image Guidance for Supra-Aortic Vessel Catheterization in Neurointerventions: A Feasibility Study

Author

Feddal, A., primary, Escalard, S., additional, Delvoye, F., additional, Fahed, R., additional, Desilles, J.P., additional, Zuber, K., additional, Redjem, H., additional, Savatovsky, J.S., additional, Ciccio, G., additional, Smajda, S., additional, Ben Maacha, M., additional, Mazighi, M., additional, Piotin, M., additional, and Blanc, R., additional

Published
2020
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38. Early successful reperfusion after endovascular therapy reduces malignant middle cerebral artery infarction occurrence in young patients with large diffusion‐weighted imaging lesions

Author

Sabben, C., primary, Desilles, J. P., additional, Charbonneau, F., additional, Savatovsky, J., additional, Morvan, E., additional, Obadia, A., additional, Raynouard, I., additional, Fela, F., additional, Escalard, S., additional, Redjem, H., additional, Smajda, S., additional, Ciccio, G., additional, Blanc, R., additional, Fahed, R., additional, Le Guerinel, C., additional, Engrand, N., additional, Ben Maacha, M., additional, Labreuche, J., additional, Mazighi, M., additional, Piotin, M., additional, and Obadia, M., additional

Published
2020
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39. Improved detection and characterization of arterial occlusion in acute ischemic stroke using contrast enhanced MRA

Author

Dhundass, Sarah, primary, Savatovsky, Julien, additional, Duron, Loïc, additional, Fahed, R., additional, Escalard, Simon, additional, Obadia, Michael, additional, Zuber, Kevin, additional, Metten, Marie Astrid, additional, Mejdoubi, Mehdi, additional, Blanc, Raphaël, additional, Sadik, Jean-Claude, additional, Collin, Adrien, additional, and Lecler, Augustin, additional

Published
2020
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41. Intravenous thrombolysis and thrombectomy decisions in acute ischemic stroke: An interrater and intrarater agreement study

Author

Ducroux, C., Fahed, R., Khoury, N. N., Gevry, G., Kalsoum, E., Labeyrie, M-A, Ziegler, D., Sauve, C., Chagnon, M., Darsaut, T. E., Raymond, J., Niclot, Philippe, Ameri, Alain, Hodel, Jerome, Gentric, Jean-Christophe, Merrien, Francois-Mathias, Jourdain, Aurore, Rouhart, Francois, Viakhireva, Irina, Timsit, Serge, Clarencon, Frederic, Pistocchi, Silvia, Rosso, Charlotte, Zavanone, Chiara, Houdart, Emmanuel, Labeyrie, Marc-Antoine, Reiner, Peggy, Gory, Benjamin, Riva, Roberto, Nighoghossian, Norbert, Cho, Tae-Hee, Derex, Laurent, Eugene, Francois, Ferré, Jean-Christophe, Le Bras, Anthony, Vannier, Stephane, Lassalle, Maria, Chivot, Cyril, Arnoux, Audrey, Alla, Philippe, Veyrieres, Jean-Brice, Marnat, Gaultier, Berge, Jerome, Olindo, Stephane, Sibon, Igor, Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Di Maria, Federico, Obadia, Michael, Sabben, Candice, Mazighi, Mikael, Redjem, Hocine, Piotin, Michel, Boisseau, William, Razlog, Lilia, Pop, Raoul, Beaujeux, Remy, Mihoc, Dan, Richter, Sebastian, Manisor, Monica, Wolff, Valerie, Quenardelle, Veronique, Zinchenko, Lisa, Diaconu, Mihaela, Yger, Marion, Delorme, Stephen, Iosif, Christina, Moulin, Thierry, Zekri, Hatem, Lallement, Francois, Vercruysse, Olivier, Papagiannaki, Christanthi, Ozkul-Wermester, Ozlem, Dargazanli, Cyril, Costalat, Vincent, Gaillard, Nicolas, Arquizan, Caroline, Cayrecastel, Mireille, Bracard, Serge, Derelle, Anne-Laure, Richard, Sebastien, Humbertjean, Lisa, Herve, Yann, Favrole, Pascal, Le Coz, Patrick, de Brouker, Thomas, Force, Marie-Isabelle, Akono, Serge, Cakmak, Serkan, Florea, Alexandru, Lalu, Thibault, Taurin, Gregory, Duong, Duc Long, Chadenat, Marie-Laure, Pico, Fernando, Allibert, Remi, Evain, Sarah, Tassan, Philippe, Berthier, Eric, Ducrocq, Xavier, Rigal, Matthieu, Boulanger, Marion, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), CHU Henri Mondor [Créteil], Service de Neuroradiologie [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Département de Mathématiques et de statistique [UdeM- Montréal] (DMS), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Service de Neurologie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Génétique et Physiopathologie des Maladies Cérébro-Vasculaires (U1161 / UMR_S 1161), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Hôpital Lariboisière-Fernand-Widal [APHP], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hospices Civils de Lyon (HCL), Department of Stroke Medicine [Lyon], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon, Departement de Neurologie (HCL), Cerebrovascular Unit [Lyon], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Health Service and Performance Research (HESPER), Université de Lyon-Université de Lyon, Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes], CHU Pontchaillou [Rennes], Neuroimagerie: méthodes et applications (Empenn), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Département de Radiologie [CHU de Rennes], Université de Rennes (UR), Institut de Recherche Technologique b-com (IRT b-com), Service de Neurologie [CHU Rennes], Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire de Bordeaux (CHU de Bordeaux), Université de Bordeaux (UB), Hôpital Foch [Suresnes], CHU Rothschild [AP-HP], Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Département de Neuroradiologie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA), CHU Saint-Antoine [AP-HP], Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Equipe de Recherche Médicale Appliquée (ERMA), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Département de Neuroradiologie[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Service de neurologie [CHRU Nancy], Service de Neurologie [Aix-en-Provence], Centre Hospitalier du Pays d'Aix, Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de radiologie [Vannes], Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
medicine.medical_specialty, Consensus, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Decision Making, Single Center, law.invention, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Combined treatment, Cohen's kappa, Randomized controlled trial, Fibrinolytic Agents, law, Medicine, Humans, Thrombolytic Therapy, 030212 general & internal medicine, Infusions, Intravenous, Acute ischemic stroke, Thrombectomy, business.industry, Reproducibility of Results, Thrombolysis, Mechanical thrombectomy, Stroke, Inter-rater reliability, Neurology, Acute Disease, Physical therapy, Administration, Intravenous, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

International audience; Purpose. - We aimed to assess agreement on intravenous tissue-plasminogen activator (IV tPA) and mechanical thrombectomy (MT) management decisions in acute ischemic stroke (AIS) patients. Secondary objectives were to assess agreement on Diffusion-Weighted-Imaging-Alberta-Stroke-Program-EArly-CT-Score (DWI-ASPECTS), and clinicians' willingness to recruit patients in a randomized controlled trial (RCT) comparing medical management with or without MT. Materials and Methods. - Studies assessing agreement of IV tPA and MT were systematically reviewed. An electronic portfolio of 41 AIS patients was sent to randomly selected providers at French stroke centers. Raters were asked 4 questions for each case: (1) What is the DWI-ASPECTS? (2) Would you perform IV tPA? (3) Would you perform MT? (4) Would you include the patient in a RCT comparing standard medical therapy with or without MT? Twenty responders were randomly selected to study intrarater agreement. Agreement was assessed using Fleiss' Kappa statistics. Results. - The review yielded two single center studies involving 2-5 raters, with various results. The electronic survey was answered by 86 physicians (60 vascular neurologists and 26 interventional neuroradiologists). The interrater agreement was moderate for IV tPA treatment decisions (kappa = 0.565 [0.420-0.680]), but only fair for MT (kappa = 0.383 [0.289-0.491]) and for combined treatment decisions (kappa = 0.399 [0.320-0.486]). The intrarater agreement was at least substantial for the majority of raters. The interrater agreement for DWI-ASPECTS was fair (kappa = 0.325 [0.276-0.387]). Physicians were willing to include a mean of 14 +/- 9 patients (33.1% +/- 21.7%) in a RCT. Conclusion. - Disagreements regarding the use of IVtPA or MT in the management of AIS patients remain frequent. Further trials are needed to resolve the numerous areas of uncertainty. (C) 2019 Elsevier Masson SAS. All rights reserved.

Published
2018

46. Prognosis and risk factors associated with asymptomatic intracranial hemorrhage after endovascular treatment of large vessel occlusion stroke: a prospective multicenter cohort study.

Author

Constant Dit Beaufils, P., Preterre, C., De Gaalon, S., Labreuche, J., Mazighi, M., Di Maria, F., Sibon, I., Marnat, G., Gariel, F., Blanc, R., Gory, B., Consoli, A., Zhu, F., Richard, S., Fahed, R., Desal, H., Lapergue, B., Guillon, B., Bourcier, R., and Piotin, Michel

Subjects
ENDOVASCULAR surgery, STROKE, COHORT analysis, HEMORRHAGE, PROGNOSIS, GROIN pain
Abstract

Background and purpose: Asymptomatic intracranial hemorrhage (aICH) is a common occurrence after endovascular treatment (EVT) for acute ischemic stroke (AIS). The aims of this study were to address its impact on 3‐month functional outcome and to identify risk factors for aICH after EVT. Methods: Patients with AIS attributable to anterior circulation large vessel occlusion who underwent EVT were enrolled in a multicenter prospective registry. Based on imaging performed 22–36 h post‐EVT, we included patients with no intracranial hemorrhage (ICH) or aICH. Poor outcome defined as a 3‐month modified Rankin Scale (mRS) score 4–6 and overall 3‐month mRS score distribution were compared according to presence/absence of aICH, and aICH subtype using logistic regression. We assessed the risk factors of aICH using a multivariate logistic regression model. Results: Of the 1526 patients included in the study, 653 (42.7%) had aICH. Patients with aICH had a higher rate of poor outcome: odds ratio (OR) 1.88 (95% confidence interval [CI] 1.44–2.44). Shift analysis of mRS score found a fully adjusted OR of 1.79 (95% CI 1.47–2.18). Hemorrhagic infarction (OR 1.63 [95% CI 1.22–2.18]) and parenchymal hematoma (OR 2.99 [95% CI 1.77–5.02]) were associated with higher risk of poor outcome. Male sex, diabetes, coronary artery disease, baseline National Institutes of Health Stroke Scale score and Alberta Stroke Program Early Computed Tomography Score, number of passes and onset to groin puncture time were independently associated with aICH. Conclusions: Patients with aICH, irrespective of the radiological pattern, have a worse functional outcome at 3 months compared with those without ICH after EVT for AIS. The number of EVT passes and the time from onset to groin puncture are factors that could be modified to reduce deleterious ICH. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Application of the DAWN clinical imaging mismatch and DEFUSE 3 selection criteria: benefit seems similar but restrictive volume cut‐offs might omit potential responders

Author

Ducroux, C., primary, Khoury, N., additional, Lecler, A., additional, Blanc, R., additional, Chetrit, A., additional, Redjem, H., additional, Ciccio, G., additional, Smajda, S., additional, Escalard, S., additional, Desilles, J.‐P., additional, Mazighi, M., additional, Ben Maacha, M., additional, Piotin, M., additional, and Fahed, R., additional

Published
2018
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