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1. Management of cytomegalovirus in adult solid organ transplant patients: GESITRA-IC-SEIMC, CIBERINFEC, and SET recommendations update

Author: Ruiz-Arabi, Elisa, Torre-Cisneros, Julian, Aguilera, Victoria, Alonso, Rodrigo, Berenguer, Marina, Bestard, Oriol, Bodro, Marta, Cantisán, Sara, Carratalà, Jordi, Castón, Juan José, Cordero, Elisa, Facundo, Carme, Fariñas, María Carmen, Fernández-Alonso, Mirian, Fernández-Ruiz, Mario, Fortún, Jesús, García-Cosío, Maria Dolores, Herrera, Sabina, Iturbe-Fernández, David, Len, Oscar, López-Medrano, Francisco, López-Oliva, María Ovidia, Los-Arcos, Ibai, Marcos, María Ángeles, Martín-Dávila, Pilar, Monforte, Víctor, Muñoz, Patricia, Navarro, David, Páez-Vega, Aurora, Pérez, Ana Belén, Redondo, Natalia, Álvarez R., Rodríguez, Rodríguez-Benot, Alberto, Rodríguez-Goncer, Isabel, San-Juan, Rafael, Sánchez-Céspedes, Javier, Valerio, Maricela, Vaquero, José Manuel, Viasus, Diego, Vidal, Elisa, and Aguado, José María
Published: 2024
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2. Recovery of dialysis patients with COVID-19: health outcomes 3 months after diagnosis in ERACODA

Author: Hemmelder, Marc H, Noordzij, Marlies, Vart, Priya, Hilbrands, Luuk B, Jager, Kitty J, Abrahams, Alferso C, Arroyo, David, Battaglia, Yuri, Ekart, Robert, Mallamaci, Francesca, Malloney, Sharon-Rose, Oliveira, Joao, Rydzewski, Andrzej, Sridharan, Sivakumar, Vogt, Liffert, Duivenvoorden, Raphaël, Gansevoort, Ron T, Franssen, Casper FM, van der Net, Jeroen B, Essig, Marie, du Buf-Vereijken, Peggy WG, van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C, Bemelman, Frederike J, Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G, Nurmohamed, Azam, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M, Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Hengst, Maaike, Konings, Constantijn JAM, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Alferes, Daniela G, Radulescu, Daniela, Zakharova, Elena V, Ambuehl, Patrice Max, Guidotti, Rebecca, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, Katicic, Dajana, Dam, Marc ten, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L, Logtenberg, Susan JJ, Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen JP, ElHafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies EJ, Hesselink, Dennis A, van Gestel, J Kal-, Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S, Verhoeven, Martine AM, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M, Debska-Slizien, Alicja, Veldhuizen, Nicoline MH, Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Nistor, Ionut, Covic, Adrian, Groeneveld, JHM, Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, and dos Santos, Augusto Cesar Soares
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Patient Safety, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Aged, Aged, 80 and over, COVID-19, COVID-19 Testing, Female, Humans, Intensive Care Units, Male, Middle Aged, Outcome Assessment, Health Care, Renal Dialysis, SARS-CoV-2, ERACODA Collaborators, dialysis, functional health status, mental health status, survival, Urology & Nephrology, Clinical sciences
Abstract: BackgroundCoronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis.MethodsWe analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression.ResultsIn 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8-6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome.ConclusionsMortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis.
Published: 2022

3. Clinical triage of patients on kidney replacement therapy presenting with COVID-19: an ERACODA registry analysis

Author: Mitra, Sandip, Jayanti, Anuradha, Vart, Priya, Coca, Armando, Gallieni, Maurizio, Øvrehus, Marius Altern, Midtvedt, Karsten, Abd ElHafeez, Samar, Gandolfini, Iliaria, Büttner, Stefan, Franssen, Casper FM, Hemmelder, Marc H, van der Net, Jeroen B, Essig, Marie, du Buf-Vereijken, Peggy WG, van Ginneken, Betty, Vogt, Nanda Maas Liffert, van Jaarsveld, Brigit C, Jager, Kitty J, Bemelman, Frederike J, Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G, Nurmohamed, Azam, Abramowicz, Daniel, Maoujoud, Sabine Verhofstede Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M, Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Hengst, Maaike, Rydzewski, rzej, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G, Zakharova, Elena V, Ambuehl, Patrice Max, Walker, rea, Winzeler, Rebecca, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Katicic, Dajana, Dam, Marc ten, Krüger, Thilo, Brzosko, Szymon, Zanen, Adriaan L, Logtenberg, Susan JJ, Fricke, Lutz, Slebe, Jeroen JP, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies EJ, Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S, Verhoeven, Martine AM, Canal, Cristina, Facundo, Carme, Ramos, Ana M, Debska-Slizien, Alicja, Veldhuizen, Nicoline MH, Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Covic, Adrian, Matceac, Irina, Nistor, Ionut, Cordos, Monica, Groeneveld, JHM, van Buren, Jolanda Jousma Marjolijn, Pereira, Fritz Diekmann Tiago Assis, Santos, Augusto Cesar S, Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Hofstra, Julia M, Franco, Antonio, Arroyo, David, Rodríguez-Ferrero, Maria Luisa, Manzanos, Sagrario Balda, Haridian Sosa Barrios, R, Ávila, Gonçalo, Laranjinha, Ivo, Mateus, Catarina, and Lemahieu, Wim
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Transplantation, Clinical Research, Kidney Disease, Prevention, Renal and urogenital, Good Health and Well Being, Aged, COVID-19, Hospitalization, Humans, Oxygen Saturation, Registries, Renal Replacement Therapy, SARS-CoV-2, Triage, dialysis, kidney, mortality, second presentation, transplantation, ERACODA Collaborators, Urology & Nephrology, Clinical sciences
Abstract: BackgroundPatients on kidney replacement therapy (KRT) are at very high risk of coronavirus disease 2019 (COVID-19). The triage pathway for KRT patients presenting to hospitals with varying severity of COVID-19 illness remains ill-defined. We studied the clinical characteristics of patients at initial and subsequent hospital presentations and the impact on patient outcomes.MethodsThe European Renal Association COVID-19 Database (ERACODA) was analysed for clinical and laboratory features of 1423 KRT patients with COVID-19 either hospitalized or non-hospitalized at initial triage and those re-presenting a second time. Predictors of outcomes (hospitalization, 28-day mortality) were then determined for all those not hospitalized at initial triage.ResultsAmong 1423 KRT patients with COVID-19 [haemodialysis (HD), n = 1017; transplant, n = 406), 25% (n = 355) were not hospitalized at first presentation due to mild illness (30% HD, 13% transplant). Of the non-hospitalized patients, only 10% (n = 36) re-presented a second time, with a 5-day median interval between the two presentations (interquartile range 2-7 days). Patients who re-presented had worsening respiratory symptoms, a decrease in oxygen saturation (97% versus 90%) and an increase in C-reactive protein (26 versus 73 mg/L) and were older (72 vs 63 years) compared with those who did not return a second time. The 28-day mortality between early admission (at first presentation) and deferred admission (at second presentation) was not significantly different (29% versus 25%; P = 0.6). Older age, prior smoking history, higher clinical frailty score and self-reported shortness of breath at first presentation were identified as risk predictors of mortality when re-presenting after discharge at initial triage.ConclusionsThis study provides evidence that KRT patients with COVID-19 and mild illness can be managed effectively with supported outpatient care and with vigilance of respiratory symptoms, especially in those with risk factors for poor outcomes. Our findings support a risk-stratified clinical approach to admissions and discharges of KRT patients presenting with COVID-19 to aid clinical triage and optimize resource utilization during the ongoing pandemic.
Published: 2021

4. Management of immunosuppressive therapy in kidney transplant recipients with COVID-19. A multicentre national study derived from the Spanish Society of Nephrology COVID registry

Author: López-Oliva, María O., Pérez-Flores, Isabel, Molina, María, José Aladrén, María, Trujillo, Hernando, Redondo-Pachón, Dolores, López, Verónica, Facundo, Carme, Villanego, Florentino, Rodríguez, Marisa, Carmen Ruiz, Maria, Antón, Paula, Rivas-Oural, Alba, Cabello, Sheila, Portolés, José, de la Vara, Lourdes, Tabernero, Guadalupe, Valero, Rosalía, Galeano, Cristina, Moral, Esperanza, Ventura, Ana, Coca, Armando, Ángel Muñoz, Miguel, Hernández-Gallego, Román, Shabaka, Amir, Ledesma, Gabriel, Bouarich, Hanane, Ángeles Rodríguez, María, Pérez Tamajón, Lourdes, Cruzado, Leónidas, Emilio Sánchez, José, and Jiménez, Carlos
Published: 2023
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5. Manejo de la inmunosupresión en pacientes trasplantados de riñón con COVID19. Estudio multicéntrico nacional derivado del registro COVID de la Sociedad Española de Nefrología

Author: López-Oliva, María O., Pérez-Flores, Isabel, Molina, María, Aladrén, M. José, Trujillo, Hernando, Redondo-Pachón, Dolores, López, Verónica, Facundo, Carme, Villanego, Florentino, Rodríguez, Marisa, Ruiz, M. Carmen, Antón, Paula, Rivas-Oural, Alba, Cabello, Sheila, Portolés, José, de la Vara, Lourdes, Tabernero, Guadalupe, Valero, Rosalía, Galeano, Cristina, Moral, Esperanza, Ventura, Ana, Coca, Armando, Muñoz, Miguel Ángel, Hernández-Gallego, Román, Shabaka, Amir, Ledesma, Gabriel, Bouarich, Hanane, Rodríguez, M. Ángeles, Pérez Tamajón, Lourdes, Cruzado, Leónidas, Sánchez, J. Emilio, and Jiménez, Carlos
Published: 2023
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6. Recommendations for living donor kidney transplantation

Author: Frutos, Miguel Ángel, Crespo, Marta, Valentín, María de la Oliva, Alonso-Melgar, Ángel, Alonso, Juana, Fernández, Constantino, García-Erauzkin, Gorka, González, Esther, González–Rinne, Ana M., Guirado, Lluis, Gutiérrez-Dalmau, Alex, Huguet, Jorge, Moral, José Luis López del, Musquera, Mireia, Paredes, David, Redondo, Dolores, Revuelta, Ignacio, Hofstadt, Carlos J Van-der, Alcaraz, Antonio, Alonso-Hernández, Ángel, Alonso, Manuel, Bernabeu, Purificación, Bernal, Gabriel, Breda, Alberto, Cabello, Mercedes, Caro-Oleas, José Luis, Cid, Joan, Diekmann, Fritz, Espinosa, Laura, Facundo, Carme, García, Marta, Gil-Vernet, Salvador, Lozano, Miquel, Mahillo, Beatriz, Martínez, María José, Miranda, Blanca, Oppenheimer, Federico, Palou, Eduard, Pérez-Saez, María José, Peri, Lluis, Rodríguez, Oscar, Santiago, Carlos, Tabernero, Guadalupe, Hernández, Domingo, Domínguez-Gil, Beatriz, and Pascual, Julio
Published: 2022
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7. Treatment of early borderline lesions in low immunological risk kidney transplant patients: a Spanish multicenter, randomized, controlled parallel-group study protocol: the TRAINING study

Author: Hernández, Domingo, Vázquez-Sánchez, Teresa, Sola, Eugenia, Lopez, Veronica, Ruiz-Esteban, Pedro, Caballero, Abelardo, Salido, Eduardo, Leon, Myriam, Rodriguez, Aurelio, Serra, Nuria, Rodriguez, Consuelo, Facundo, Carme, Perello, Manel, Silva, Irene, Marrero-Miranda, Domingo, Cidraque, Ignacio, Moreso, Francesc, Guirado, Luis, Serón, Daniel, and Torres, Armando
Published: 2022
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8. A comprehensive assessment of long-term SARS-CoV-2–specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients

Author: Favà, Alexandre, Donadeu, Laura, Jouve, Thomas, Gonzalez-Costello, José, Lladó, Laura, Santana, Carolina, Toapanta, Néstor, Lopez, Manuel, Pernin, Vincent, Facundo, Carme, Cabañas, Nuria Serra, Thaunat, Olivier, Crespo, Marta, Llinàs-Mallol, Laura, Revuelta, Ignacio, Sabé, Nuria, Rombauts, Alexander, Calatayud, Laura, Ardanuy, Carmen, Esperalba, Juliana, Fernandez, Candela, Lozano, Juan J., Preyer, Rosemarie, Strecker, Kevin, Couceiro, Carlos, García-Romero, Elena, Cachero, Alba, Meneghini, Maria, Torija, Alba, Le Quintrec, Moglie, Melilli, Edoardo, Cruzado, Josep Maria, Polo, Carolina, Moreso, Francesc, Crespo, Elena, and Bestard, Oriol
Published: 2022
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9. Recomendaciones para el trasplante renal de donante vivo

Author: Frutos, Miguel Ángel, Crespo, Marta, Valentín, María de la Oliva, Alonso-Melgar, Ángel, Alonso, Juana, Fernández, Constantino, García-Erauzkin, Gorka, González, Esther, González-Rinne, Ana M., Guirado, Lluis, Gutiérrez-Dalmau, Alex, Huguet, Jorge, López del Moral, José Luis, Musquera, Mireia, Paredes, David, Redondo, Dolores, Revuelta, Ignacio, Van-der Hofstadt, Carlos J., Alcaraz, Antonio, Alonso-Hernández, Ángel, Alonso, Manuel, Bernabeu, Purificación, Bernal, Gabriel, Breda, Alberto, Cabello, Mercedes, Caro-Oleas, José Luis, Cid, Joan, Diekmann, Fritz, Espinosa, Laura, Facundo, Carme, García, Marta, Gil-Vernet, Salvador, Lozano, Miquel, Mahillo, Beatriz, Martínez, María José, Miranda, Blanca, Oppenheimer, Federico, Palou, Eduard, Pérez-Saez, María José, Peri, Lluis, Rodríguez, Oscar, Santiago, Carlos, Tabernero, Guadalupe, Hernández, Domingo, Domínguez-Gil, Beatriz, and Pascual, Julio
Published: 2022
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10. Benefits of Living Over Deceased Donor Kidney Transplantation in Elderly Recipients. A Propensity Score Matched Analysis of a Large European Registry Cohort.

Author: Toapanta, Néstor, Comas, Jordi, Revuelta, Ignacio, Manonelles, Anna, Facundo, Carme, Pérez-Saez, María José, Vila, Anna, Arcos, Emma, Tort, Jaume, Giral, Magali, Naesens, Maarten, Kuypers, Dirk, Asberg, Anders, Moreso, Francesc, and Bestard, Oriol
Subjects: PROPENSITY score matching, KIDNEY transplantation, BRAIN death, TREATMENT effectiveness, GRAFT survival
Abstract: Although kidney transplantation from living donors (LD) offers better long-term results than from deceased donors (DD), elderly recipients are less likely to receive LD transplants than younger ones. We analyzed renal transplant outcomes from LD versus DD in elderly recipients with a propensity-matched score. This retrospective, observational study included the first single kidney transplants in recipients aged =65 years from two European registry cohorts (2013-2020, n = 4,257). Recipients of LD (n = 408), brain death donors (BDD, n = 3,072), and controlled cardiocirculatory death donors (cDCD, n = 777) were matched for donor and recipient age, sex, dialysis time and recipient diabetes. Major graft and patient outcomes were investigated. Unmatched analyses showed that LD recipients were more likely to be transplanted preemptively and had shorter dialysis times than any DD type. The propensity score matched Cox's regression analysis between LD and BDD (387-pairs) and LD and cDCD (259-pairs) revealing a higher hazard ratio for graft failure with BDD (2.19 [95% CI: 1.16-4.15], p = 0.016) and cDCD (3.38 [95% CI: 1.79-6.39], p < 0.001). One-year eGFR was higher in LD transplants than in BDD and cDCD recipients. In elderly recipients, LD transplantation offers superior graft survival and renal function compared to BDD or cDCD. This strategy should be further promoted to improve transplant outcomes. [ABSTRACT FROM AUTHOR]
Published: 2024
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11. Live donor kidney transplantation. Situation analysis and roadmap

Author: de la Oliva Valentín, María, Hernández, Domingo, Crespo, Marta, Mahillo, Beatriz, Beneyto, Isabel, Martínez, Itziar, Kanter, Julia, Calderari, Elena, Gil-Vernet, Salvador, Sánchez, Sara, Agüera, Maria Luisa, Bernal, Gabriel, de Santiago, Carlos, Díaz-Corte, Carmen, Díaz, Cándido, Espinosa, Laura, Facundo, Carme, Fernández-Lucas, Milagros, Ferreiro, Tamara, García-Erauzkin, Gorka, García-Alvarez, Teresa, Fraile, Pilar, González-Rinne, Ana, González-Soriano, María José, González, Esther, Gutiérrez-Dalmau, Alex, Jiménez, Carlos, Lauzurica, Ricardo, Lorenzo, Inmaculada, Martín-Moreno, Paloma L., Moreso, Francesc, de Gracia, María Carmen, Pérez-Flores, Isabel, Ramos-Verde, Ana, Revuelta, Ignacio, Rodríguez-Ferrero, María Luisa, Ruiz, Juan Carlos, Sánchez-Sobrino, Beatriz, and Domínguez-Gil, Beatriz
Published: 2022
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12. Trasplante renal de donante vivo. Análisis de situación y hoja de ruta

Author: Valentín, María de la Oliva, Hernández, Domingo, Crespo, Marta, Mahillo, Beatriz, Beneyto, Isabel, Martínez, Itziar, Kanter, Julia, Calderari, Elena, Gil-Vernet, Salvador, Sánchez, Sara, Agüera, Maria Luisa, Bernal, Gabriel, de Santiago, Carlos, Díaz-Corte, Carmen, Díaz, Cándido, Espinosa, Laura, Facundo, Carme, Fernández-Lucas, Milagros, Ferreiro, Tamara, García-Erauzkin, Gorka, García-Alvarez, Teresa, Fraile, Pilar, González-Rinne, Ana, González-Soriano, María José, González, Esther, Gutiérrez-Dalmau, Alex, Jiménez, Carlos, Lauzurica, Ricardo, Lorenzo, Inmaculada, Martín-Moreno, Paloma L., Moreso, Francesc, de Gracia, María Carmen, Pérez-Flores, Isabel, Ramos-Verde, Ana, Revuelta, Ignacio, Rodríguez-Ferrero, María Luisa, Ruiz, Juan Carlos, Sánchez-Sobrino, Beatriz, and Domínguez-Gil, Beatriz
Published: 2022
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13. COVID-19 in transplant recipients: The Spanish experience

Author: Coll, Elisabeth, Fernández-Ruiz, Mario, Sánchez-Álvarez, J. Emilio, Martínez-Fernández, José R., Crespo, Marta, Gayoso, Jorge, Bada-Bosch, Teresa, Oppenheimer, Federico, Moreso, Francesc, López-Oliva, María O., Melilli, Edoardo, Rodríguez-Ferrero, Marisa L., Bravo, Carlos, Burgos, Elena, Facundo, Carme, Lorenzo, Inmaculada, Yañez, Íñigo, Galeano, Cristina, Roca, Ana, Cabello, Mercedes, Gómez-Bueno, Manuel, García-Cosío, M<ce:sup loc='post">a</ce:sup>Dolores, Graus, Javier, Lladó, Laura, de Pablo, Alicia, Loinaz, Carmelo, Aguado, Beatriz, Hernández, Domingo, and Domínguez-Gil, Beatriz
Published: 2021
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14. Clinical characteristics and risk factors for severe COVID-19 in hospitalized kidney transplant recipients: A multicentric cohort study

Author: Favà, Alexandre, Cucchiari, David, Montero, Nuria, Toapanta, Nestor, Centellas, Francisco J., Vila-Santandreu, Anna, Coloma, Ana, Meneghini, Maria, Manonelles, Anna, Sellarés, Joana, Torres, Irina, Gelpi, Rosana, Lorenzo, Inmaculada, Ventura-Aguiar, Pedro, Cofan, Frederic, Torregrosa, Jose V., Perelló, Manel, Facundo, Carme, Seron, Daniel, Oppenheimer, Federico, Bestard, Oriol, Cruzado, Josep M., Moreso, Francesc, and Melilli, Edoardo
Published: 2020
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15. Involvement of Succinate Dehydrogenase (SDH) in Deceased Kidney Donorsʼ Inflammation: PUB268

Author: Guillen-gomez, Elena, Silva, Irene, Solana, Carla G., Vilardell, Jordi, Astiarraga, Brenno D., Fernandez-Veledo, Sonia, Caballero, Francisco, Cebrecos, Jesus L., Facundo, Carme, Arce, Yolanda, Guirado, Lluis, and Diaz Encarnacion, Montserrat M.
Published: 2021
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16. COVID-19 in Solid Organ Transplant Recipients in Spain Throughout 2020: Catching the Wave?

Author: Coll, Elisabeth, Fernández-Ruiz, Mario, Padilla, María, Moreso, Francesc, Hernández-Vicente, Ana, Yañez, Iñigo, Molina, María, Vázquez-Sánchez, Teresa, Crespo, Marta, Facundo, Carme, Rodríguez-Ferrero, María Luisa, Ruiz Fuentes, María Carmen, Loinaz, Carmelo, Bernal, Gabriel, Melilli, Edoardo, Bravo, Carlos, Diekmann, Fritz, Lladó, Laura, García-Álvarez, Teresa M., Salcedo, Magdalena, Beneyto, Isabel, Castells, Lluis, Alonso, Rodrigo, Rodríguez-Benot, Alberto, Díaz-Corte, Carmen, Graus, Javier, Ortiz-Bautista, Carlos, García-Cosío, María Dolores, Hinojal, Rosa, Peña, Lucía, and Domínguez-Gil, Beatriz
Published: 2021
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17. Robot-assisted Kidney Transplantation with Regional Hypothermia Using Grafts with Multiple Vessels After Extracorporeal Vascular Reconstruction: Results from the European Association of Urology Robotic Urology Section Working Group

Author: Siena, Giampaolo, Campi, Riccardo, Decaestecker, Karel, Tuğcu, Volkan, Sahin, Selcuk, Alcaraz, Antonio, Musquera, Mireia, Territo, Angelo, Gausa, Luis, Randon, Caren, Stockle, Michael, Janssen, Martin, Fornara, Paolo, Mohammed, Nasreldin, Guirado, Luis, Facundo, Carme, Doumerc, Nicolas, Vignolini, Graziano, Breda, Alberto, and Serni, Sergio
Published: 2018
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18. Association of obesity with 3-month mortality in kidney failure patients with COVID-19

Author: Tantisattamo, Ekamol, Imhof, Celine, Jager, Kitty J., Hilbrands, Luuk B., Guidotti, Rebecca, Islam, Mahmud, Katicic, Dajana, Konings, Constantijn, Molenaar, Femke M., Nistor, Ionut, Noordzij, Marlies, Rodríguez Ferrero, Mariá Luisa, Verhoeven, Martine A. M., de Vries, Aiko P. J., Kalantar-Zadeh, Kamyar, Gansevoort, Ron T., Vart, Priya, van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, Joaõ, Alferes, Daniela G., Zakharova, Elena V., Ambuehl, Patrice Max, Walker, Andrea, Lepeytre, Fanny, Rabate, Clementine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J. P., Elhafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Hesselink, Dennis A., Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, el-Wakil, Hala S., Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Covic, Adrian, Groeneveld, J. H. M., Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S., Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M., Siezenga, Machiel A., Franco, Antonio, Arroyo, David, Castellano, Sandra, Manzanos, Sagrario Balda, Haridian Sosa Barrios, R., Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Safak, Seda, Hollander, Daan A. M. J., Büttner, Stefan, Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petruliene, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Hemmelder, Marc H., Kumar, Mohan N., di Luca, Marina, Tuǧlular, Serhan Z., Ziekenhuis, Martini, Kramer, Andrea B., Beerenhout, Charles, Luik, Peter T., Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y., Stepanov, Vadim A., Zulkarnaev, Alexey B., Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, Els van de Logt, Anne, Maas, Rutger, Duivenvoorden, Raphaël, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J. M., Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J., Roca, Ana Maria, Nauta, Ferdau, Sahin, Idris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K. I., Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M., Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P., Meijer, Esther, Sanders, Jan Stephan F., Franssen, Casper F. M., Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimsevicius, Laurynas, Righetti, Marco, Heitink-ter Braak, Nicole, Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, ACS - Pulmonary hypertension & thrombosis, Nephrology, ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, Clinical sciences, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, ACS - Diabetes & metabolism, Internal Medicine, Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), van der Net, Jeroen B, Essig, Marie, du Buf-Vereijken, Peggy W G, van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C, Bemelman, Frederike J, Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G, Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M, Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G, Zakharova, Elena V, Ambuehl, Patrice Max, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, Ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L, Logtenberg, Susan J J, Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J P, ElHafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E J, Hesselink, Dennis A, Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M, Debska-Slizien, Alicja, Veldhuizen, Nicoline M H, Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Covic, Adrian, Groeneveld, J H M, Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S, Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M, Siezenga, Machiel A, Franco, Antonio, Arroyo, David, Castellano, Sandra, Manzanos, Sagrario Balda, Haridian Sosa Barrios, R., Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Şafak, Seda, Hollander, Daan A M J, Büttner, Stefan, Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petrulienė, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M, Christiaans, Maarten H L, Hemmelder, Marc H, Kumar N, Mohan, Di Luca, Marina, Tuğlular, Serhan Z, Ziekenhuis, Martini, Kramer, Andrea B, Beerenhout, Charles, Luik, Peter T, Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y, Stepanov, Vadim A, Zulkarnaev, Alexey B, Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W H, Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, Els van de Logt, Anne, Maas, Rutger, Duivenvoorden, Raphaël, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J M, Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V, Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E A, Harty, John C, Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J, Roca, Ana Maria, Nauta, Ferdau, Sahin, İdris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K I, Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M, Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P, Meijer, Esther, Sanders, Jan Stephan F, Franssen, Casper F M, Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C, van Zuilen, Arjan D, Meijvis, Sabine C A, Dolmans, Helma, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J, van Kuijk, Willi H M, Stikkelbroeck, Lonneke W H, Hermans, Marc M H, Rimševičius, Laurynas, Righetti, Marco, and Heitink-Ter Braak, Nicole
Subjects: Transplantation, COVID-19, infectious diseases, mortality, DIALYSIS PATIENTS, kidney failure, BODY-MASS INDEX, obesity paradox, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], TRANSPLANT, SDG 3 - Good Health and Well-being, Nephrology, ERACODA, reverse epidemiology, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract: Background In the general population with coronavirus disease 2019 (COVID-19), obesity is associated with an increased risk of mortality. Given the typically observed obesity paradox among patients on kidney function replacement therapy (KFRT), especially dialysis patients, we examined the association of obesity with mortality among dialysis patients or living with a kidney transplant with COVID-19. Methods Data from the European Renal Association COVID-19 Database (ERACODA) were used. KFRT patients diagnosed with COVID-19 between 1 February 2020 and 31 January 2021 were included. The association of Quetelet's body mass index (BMI) (kg/m2), divided into: Results In 3160 patients on KFRT (mean age: 65 years, male: 61%), 99 patients were lean, 1151 normal weight (reference), 1160 overweight, 525 obese I and 225 obese II/III. During follow-up of 3 months, 28, 20, 21, 23 and 27% of patients died in these categories, respectively. In the fully adjusted model, the hazard ratios (HRs) for 3-month mortality were 1.65 [95% confidence interval (CI): 1.10, 2.47], 1 (ref.), 1.07 (95% CI: 0.89, 1.28), 1.17 (95% CI: 0.93, 1.46) and 1.71 (95% CI: 1.27, 2.30), respectively. Results were similar among dialysis patients (N = 2343) and among those living with a kidney transplant (N = 817) (Pinteraction = 0.99), but differed by sex (Pinteraction = 0.019). In males, the HRs for the association of aforementioned BMI categories with 3-month mortality were 2.07 (95% CI: 1.22, 3.52), 1 (ref.), 0.97 (95% CI: 0.78. 1.21), 0.99 (95% CI: 0.74, 1.33) and 1.22 (95% CI: 0.78, 1.91), respectively, and in females corresponding HRs were 1.34 (95% CI: 0.70, 2.57), 1 (ref.), 1.31 (95% CI: 0.94, 1.85), 1.54 (95% CI: 1.05, 2.26) and 2.49 (95% CI: 1.62, 3.84), respectively. Conclusion In KFRT patients with COVID-19, on dialysis or a kidney transplant, obesity is associated with an increased risk of mortality at 3 months. This is in contrast to the obesity paradox generally observed in dialysis patients. Additional studies are required to corroborate the sex difference in the association of obesity with mortality.
Published: 2022

19. Erratum to “Recommendations for living donor kidney transplantation”

Author: Frutos, Miguel Ángel, primary, Crespo, Marta, additional, Valentín, María de la Oliva, additional, Alonso-Melgar, Ángel, additional, Alonso, Juana, additional, Fernández, Constantino, additional, García-Erauzkin, Gorka, additional, González, Esther, additional, González-Rinne, Ana M., additional, Guirado, Lluis, additional, Gutiérrez-Dalmau, Alex, additional, Huguet, Jorge, additional, Moral, José Luis López del, additional, Musquera, Mireia, additional, Paredes, David, additional, Redondo, Dolores, additional, Revuelta, Ignacio, additional, Hofstadt, Carlos J Van-der, additional, Alcaraz, Antonio, additional, Alonso-Hernández, Ángel, additional, Alonso, Manuel, additional, Bernabeu, Purificación, additional, Bernal, Gabriel, additional, Breda, Alberto, additional, Cabello, Mercedes, additional, Caro-Oleas, José Luis, additional, Cid, Joan, additional, Diekmann, Fritz, additional, Espinosa, Laura, additional, Facundo, Carme, additional, García, Marta, additional, Gil-Vernet, Salvador, additional, Lozano, Miquel, additional, Mahillo, Beatriz, additional, Martínez, María José, additional, Miranda, Blanca, additional, Oppenheimer, Federico, additional, Palou, Eduard, additional, Pérez-Saez, María José, additional, Peri, Lluis, additional, Rodríguez, Oscar, additional, Santiago, Carlos, additional, Tabernero, Guadalupe, additional, Hernández, Domingo, additional, Domínguez-Gil, Beatriz, additional, and Pascual, Julio, additional
Published: 2023
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20. Fe de errores de «Recomendaciones para el trasplante renal de donante vivo»

Author: Frutos, Miguel Ángel, primary, Crespo, Marta, additional, Valentín, María de la Oliva, additional, Alonso-Melgar, Ángel, additional, Alonso, Juana, additional, Fernández, Constantino, additional, García-Erauzkin, Gorka, additional, González, Esther, additional, González-Rinne, Ana M., additional, Guirado, Lluis, additional, Gutiérrez-Dalmau, Alex, additional, Huguet, Jorge, additional, López del Moral, José Luis, additional, Musquera, Mireia, additional, Paredes, David, additional, Redondo, Dolores, additional, Revuelta, Ignacio, additional, Van-der Hofstadt, Carlos J., additional, Alcaraz, Antonio, additional, Alonso-Hernández, Ángel, additional, Alonso, Manuel, additional, Bernabeu, Purificación, additional, Bernal, Gabriel, additional, Breda, Alberto, additional, Cabello, Mercedes, additional, Caro-Oleas, José Luis, additional, Cid, Joan, additional, Diekmann, Fritz, additional, Espinosa, Laura, additional, Facundo, Carme, additional, García, Marta, additional, Gil-Vernet, Salvador, additional, Lozano, Miquel, additional, Mahillo, Beatriz, additional, Martínez, María José, additional, Miranda, Blanca, additional, Oppenheimer, Federico, additional, Palou, Eduard, additional, Pérez-Saez, María José, additional, Peri, Lluis, additional, Rodríguez, Oscar, additional, Santiago, Carlos, additional, Tabernero, Guadalupe, additional, Hernández, Domingo, additional, Domínguez-Gil, Beatriz, additional, and Pascual, Julio, additional
Published: 2023
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21. Live donor kidney transplantation. Situation analysis and roadmap

Author: Valentín, María de la Oliva, Hernández, Domingo, Crespo, Marta, Mahillo, Beatriz, Beneyto, Isabel, Martínez, Itziar, Kanter, Julia, Calderari, Elena, Gil-Vernet, Salvador, Sánchez, Sara, Agüera, Maria Luisa, Bernal, Gabriel, de Santiago, Carlos, Díaz-Corte, Carmen, Díaz, Cándido, Espinosa, Laura, Facundo, Carme, Fernández-Lucas, Milagros, Ferreiro, Tamara, García-Erauzkin, Gorka, García-Alvarez, Teresa, Fraile, Pilar, González-Rinne, Ana, González-Soriano, María José, González, Esther, Gutiérrez-Dalmau, Alex, Jiménez, Carlos, Lauzurica, Ricardo, Lorenzo, Inmaculada, Martín-Moreno, Paloma L, Moreso, Francesc, de Gracia, María Carmen, Pérez-Flores, Isabel, Ramos-Verde, Ana, Revuelta, Ignacio, Rodríguez-Ferrero, María Luisa, Ruiz, Juan Carlos, Sánchez-Sobrino, Beatriz, and Domínguez-Gil, Beatriz
Subjects: Proceso de donación de vivo, Living donation process, Self-assessment of the living donation process, Graft Survival, Trasplante renal de donante vivo, Living donation evolution, Living donor kidney transplantation, Kidney, Autoevaluación del proceso de donación de vivo, Kidney Transplantation, Chronic kidney disease treatment, Benchmarking, Optimización de la donación de vivo, Optimization of living kidney donation, Nephrology, Living Donors, Humans, Kidney Failure, Chronic, Evolución donación de vivo, Tratamiento de la enfermedad renal crónica avanzada
Abstract: Living donor kidney transplantation (LDKT) is the best treatment option for end stage renal disease in terms of both patient and graft survival. However, figures on LDKT in Spain that had been continuously growing from 2005 to 2014, have experienced a continuous decrease in the last five years. One possible explanation for this decrease is that the significant increase in the number of deceased donors in Spain during the last years, both brain death and controlled circulatory death donors, might have generated the false idea that we have coped with the transplant needs. Moreover, a greater number of deceased donor kidney transplants have caused a heavy workload for the transplant teams. Furthermore, the transplant teams could have moved on to a more conservative approach to the information and assessment of patients and families considering the potential long-term risks for donors in recent papers. However, there is a significant variability in the LDKT rate among transplant centers and regions in Spain independent of their deceased donor rates. This fact and the fact that LDKT is usually a preemptive option for patients with advanced chronic renal failure, as time on dialysis is a negative independent factor for transplant outcomes, lead us to conclude that the decrease in LDKT depends on other factors. Thus, in the kidney transplant annual meeting held at ONT site in 2018, a working group was created to identify other causes for the decrease of LDKT in Spain and its relationship with the different steps of the process. The group was formed by transplant teams, a representative of the transplant group of the Spanish Society of Nephrology (SENTRA), a representative of the Spanish Society of Transplants (SET) and representatives of the Spanish National Transplant Organization (ONT). A self-evaluation survey that contains requests about the phases of the LDKT processes (information, donor work out, informed consent, surgeries, follow-up and human resources) were developed and sent to 33 LDKT teams. All the centers answered the questionnaire. The analysis of the answers has resulted in the creation of a national analysis of strengths, weaknesses, opportunities, threats (SWOT) of the LDKT program in Spain and the development of recommendations targeted to improve every step of the donation process. The work performed, the conclusions and recommendations provided, have been reflected in the following report: Spanish living donor kidney transplant program assessment: recommendations for optimization. This document has also been reviewed by a panel of experts, representatives of the scientific societies (Spanish Society of Urology (AEU), Spanish Society of Nephrology Nursery (SEDEN), Spanish Society of Immunology (SEI/GETH)) and the patient association ALCER. Finally, the report has been submitted to public consultation, reaching ample consensus. In addition, the transplant competent authorities of the different regions in Spain have adopted the report at institutional level. The work done and the recommendations to optimize LDKT are summarized in the present manuscript, organized by the different phases of the donation process. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.
Published: 2022

22. Robotic kidney transplantation: one year after the beginning

Author: Breda, Alberto, Territo, Angelo, Gausa, Lluis, Rodríguez-Faba, Oscar, Caffaratti, Jorge, de León, Javier Ponce, Guirado, Lluis, Facundo, Carme, Guazzieri, Marco, Guttilla, Andrea, and Villavicencio, Humberto
Published: 2017
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23. COVID-19-related mortality in kidney transplant and haemodialysis patients

Author: Goffin, Eric, Candellier, Alexandre, Vart, Priya, Noordzij, Marlies, Arnol, Miha, Covic, Adrian, Lentini, Paolo, Malik, Shafi, Reichert, Louis J., Sever, Mehmet S., Watschinger, Bruno, Jager, Kitty J., Gansevoort, Ron T., van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Vogt, Liffert, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Avitum, B. Braun, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Hengst, Maaike, Rydzewski, Andrzej, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G., Zakharova, Elena V., Ambuehl, Patrice Max, Walker, Andrea, Winzeler, Rebecca, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Katicic, Dajana, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Slebe, Jeroen J. P., Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Eiselt, Jaromir, Kielberger, Lukas, el-Wakil, Hala S., Verhoeven, Martine A. M., Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Matceac, Irina, Nistor, Ionut, Cordos, Monica, Groeneveld, J. H. M., Jousma, Jolanda, van Buren, Marjolijn, Elhafeez, Samar Abd, Diekmann, Fritz, Pereira, Tiago Assis, Santos, Augusto Cesar S., Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Hofstra, Julia M., Franco, Antonio, Arroyo, David, Rodríguez-Ferrero, Maria Luisa, Manzanos, Sagrario Balda, Barrios, R. Haridian Sosa, Ávila, Gonçalo, Laranjinha, Ivo, Mateus, Catarina, Lemahieu, Wim, Dirim, Ahmet Burak, Demir, Erol, Å afak, Seda, Turkmen, Aydin, Hollander, Daan A. M. J., Büttner, Stefan, de Vries, Aiko P. J., Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petruliene, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Hemmelder, Marc, Kumar, Mohan N., di Luca, Marina, Tuǧlular, Serhan Z., Kramer, Andrea, Beerenhout, Charles, Luik, Peter T., Kerschbaum, Julia, Tiefenthaler, Martin, Adema, Aaltje Y., Stepanov, Vadim A., Zulkarnaev, Alexey B., Turkmen, Kultigin, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Duivenvoorden, Raphaël, Hilbrands, Luuk, Kerckhoffs, Angele, Maas, Rutger, Lebedeva, Olga, Lopez, Veronica, Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J., Roca, Ana Maria, Nauta, Ferdau, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, Meijers, Björn K. I., Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnelier, Annelies, Wissing, Karl M., de Arriba, Gabriel, Dedinska, Ivana, Pessolano, Giuseppina, Gandolfini, Ilaria, Maggiore, Umberto, Papachristou, Evangelos, Franssen, Casper F. M., Berger, Stefan P., Meijer, Esther, Özyilmaz, Akin, Sanders, Jan Stephan F., Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Ekart, Robert, Abrahams, Alferso C., Molenaar, Femke M., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Tantisattamos, Ekamol, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Sabiu, Gianmarco, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimsevicius, Laurynas, Righetti, Marco, Islam, Mahmud, Braak, Nicole Heitink-Ter, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Internal Medicine, Clinical sciences, Nephrology, ACS - Diabetes & metabolism, AII - Inflammatory diseases, AII - Infectious diseases, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Medical Informatics, ACS - Pulmonary hypertension & thrombosis, APH - Aging & Later Life, APH - Quality of Care, ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, and APH - Global Health
Subjects: medicine.medical_specialty, kidney, Original Article - Dialysis, medicine.medical_treatment, infectious diseases, law.invention, Kidney Failure, SDG 3 - Good Health and Well-being, Renal Dialysis, Risk Factors, law, Internal medicine, medicine, Humans, COVID-19, dialysis, mortality, transplantation, Registries, Renal replacement therapy, Chronic, AcademicSubjects/MED00340, Kidney transplantation, Dialysis, Transplantation, SARS-CoV-2, business.industry, Kidney Transplantation/adverse effects, Hazard ratio, medicine.disease, Kidney Transplantation, Intensive care unit, Comorbidity, Transplant Recipients, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Kidney Failure, Chronic/therapy, Nephrology, Kidney Failure, Chronic, Hemodialysis, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business
Abstract: BACKGROUND AND AIMS: Studies examining kidney failure patients with COVID-19 reported higher mortality in hemodialysis patients than in kidney transplant recipients. However, hemodialysis patients are often older and have more comorbidities. This study investigated the association of type of kidney replacement therapy with COVID-19 severity adjusting for differences in characteristics. METHOD: Data were retrieved from the European Renal Association COVID-19 Database (ERACODA), which includes kidney replacement therapy patients diagnosed with COVID-19 from all over Europe. We included all kidney transplant recipients and hemodialysis patients who presented between February 1st and December 1st 2020 and had complete information reason for COVID-19 screening and vital status at day 28. The diagnosis of COVID-19 was made based on a PCR of a nasal or pharyngeal swab specimens and/or COVID-19 compatible findings on a lung CT scan. The association of kidney transplantation or hemodialysis with 28-day mortality was examined using Cox proportional-hazards regression models adjusted for age, sex, frailty and comorbidities. Additionally, this association was investigated in the subsets of patients that were screened because of symptoms or have had routine screening. RESULTS: A total of 1,670 patients (496 functional kidney transplant recipients and 1,174 hemodialysis patients) were examined. 16.9% of kidney transplant recipients and 23.9% of hemodialysis patients died within 28 days of presentation. In an unadjusted model, the risk of 28-day mortality was 33% lower in kidney transplant recipients compared with hemodialysis patients (hazard ratio (HR): 0.67, 95% CI: 0.52, 0.85). However, in an age, sex and frailty adjusted model, the risk of 28-day mortality was 29% higher in kidney transplant recipients (HR=1.29, 95% CI: 1.00, 1.68), whereas in a fully adjusted model the risk was even 43% higher (HR=1.43, 95% CI: 1.06, 1.93). This association in patients who were screened because of symptoms (n=1,145) was similar (fully adjusted model HR=1.46, 95% CI: 1.05, 2.04). Results were similar when other endpoints were studied (e.g. risk for hospitalization, ICU admission or mortality beyond 28 days) as well as across subgroups. Only age was found to interact significantly, suggesting that the increased mortality risk associated with kidney transplantation was especially present in elderly subjects. CONCLUSION: In this study, kidney transplant recipients had a greater risk of a more severe course of COVID-19 compared with hemodialysis patients when adjusted for age, sex and comorbidities.
Published: 2021

24. Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy

Author: Vart, Priya, Duivenvoorden, Raphaël, Adema, Aaltje, Covic, Adrian, Finne, Patrik, Braak, Nicole Heijtink-ter, Laine, Kaisa, Noordzij, Marlies, Schouten, Marcel, Jager, Kitty J., Gansevoort, Ron T., van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Konings, Constantijn, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G., Zakharova, Elena V., Ambühl, Patrice Max, Guidotti, Rebecca, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, Katicic, Dajana, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J. P., ElHafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Hesselink, Dennis A., Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S., Verhoeven, Martine, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Nistor, Ionut, Groeneveld, J. H.M., Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S., Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M., Siezenga, Machiel A., Franco, Antonio, Arroyo, David, Castellano, Sandra, Rodríguez-Ferrero, Maria Luisa, Manzanos, Sagrario Balda, Barrios, R. Haridian Sosa, Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Şafak, Seda, Hollander, Daan A. M. J., Büttner, Stefan, de Vries, Aiko P. J., Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petrulienė, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Hemmelder, Marc H., MohanKumar, N., Di Luca, Marina, Tuğlular, Serhan Z., Kramer, Andrea B., Beerenhout, Charles, Luik, Peter T., Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Stepanov, Vadim A., Zulkarnaev, Alexey B., Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, van de Logt, Anne Els, Maas, Rutger, Hilbrands, Luuk B., Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J. M., Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Rychlik, Ivan, Cabezas-Reina, Carlos J., Roca, Ana Maria, Nauta, Ferdau, Sahin, İdris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K. I., Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M., Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P., Sanders, Jan Stephan F., Franssen, Casper F. M., Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C., Molenaar, Femke M., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Tantisattamo, Ekamol, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimševičius, Laurynas, Righetti, Marco, Islam, Mahmud, Clinical sciences, Nephrology, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, Internal Medicine, Department of Medicine, Clinicum, University of Helsinki, Helsinki University Hospital Area, ACS - Diabetes & metabolism, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, and UCL - (SLuc) Service de néphrologie
Subjects: Male, kidney, Transplant, infectious diseases, Kidney, All institutes and research themes of the Radboud University Medical Center, COVID‐19, Renal Dialysis, Risk Factors, risk factors, Humans, Eracoda, Aged, Sex Characteristics, Multidisciplinary, Dialysis patients, Kidney Transplantation/adverse effects, COVID-19, Middle Aged, Kidney Transplantation, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Nephrology, 3121 General medicine, internal medicine and other clinical medicine, mortality risk, Immunosuppressive Agents/therapeutic use, Female, Immunosuppressive Agents
Abstract: In the general population with COVID-19, the male sex is an established risk factor for mortality, in part due to a more robust immune response to COVID-19 in women. Because patients on kidney function replacement therapy (KFRT) have an impaired immune response, especially kidney transplant recipients due to their use of immunosuppressants, we examined whether the male sex is still a risk factor for mortality among patients on KFRT with COVID-19. From the European Renal Association COVID-19 Database (ERACODA), we examined patients on KFRT with COVID-19 who presented between February 1st, 2020, and April 30th, 2021. 1204 kidney transplant recipients (male 62.0%, mean age 56.4 years) and 3206 dialysis patients (male 61.8%, mean age 67.7 years) were examined. Three-month mortality in kidney transplant recipients was 16.9% in males and 18.6% in females (p = 0.31) and in dialysis patients 27.1% in males and 21.9% in females (p = 0.001). The adjusted HR for the risk of 3-month mortality in males (vs females) was 0.89 (95% CI 65, 1.23, p = 0.49) in kidney transplant recipients and 1.33 (95% CI 1.13, 1.56, p = 0.001) in dialysis patients (pinteraction = 0.02). In a fully adjusted model, the aHR for the risk of 3-month mortality in kidney transplant recipients (vs. dialysis patients) was 1.39 (95% CI 1.02, 1.89, p = 0.04) in males and 2.04 (95% CI 1.40, 2.97, p interaction = 0.02). In patients on KFRT with COVID-19, the male sex is not a risk factor for mortality among kidney transplant recipients but remains a risk factor among dialysis patients. The use of immunosuppressants in kidney transplant recipients, among other factors, may have narrowed the difference in the immune response to COVID-19 between men and women, and therefore reduced the sex difference in COVID-19 mortality risk.
Published: 2022

25. COVID-19 Pandemic Waves and Mortality Among Patients on Kidney Replacement Therapy

Author: Vart, Priya, primary, Jager, Kitty J., additional, Arnol, Miha, additional, Duivenvoorden, Raphaël, additional, Franssen, Casper F.M., additional, Groeneveld, Marc, additional, Hemmelder, Marc H., additional, Lepeytre, Fanny, additional, Malfait, Thomas, additional, Midtvedt, Karsten, additional, Mitra, Sandip, additional, Facundo, Carme, additional, Noordzij, Marlies, additional, Reina, Carlos C., additional, Safak, Seda, additional, Toapanta, Nestor, additional, Hilbrands, Luuk B., additional, and Gansevoort, Ron T., additional
Published: 2022
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26. Guidelines for living donor kidney transplantation

Author: Frutos, Miguel Angel, Crespo, Marta, de la Oliva Valentin, Maria, Alonso-Melgar, Angel, Alonso, Juana, Fernandez, Constantino, Garcia-Erauzkin, Gorka, Gonzalez, Esther, Gonzalez-Rinne, Ana M., Guirado, Lluis, Gutierrez-Dalmau, Alex, Huguet, Jorge, Lopez del Moral, Jose Luis, Musquera, Mireia, Paredes, David, Redondo, Dolores, Revuelta, Ignacio, Van-der Hofstadt, Carlos J., Alcaraz, Antonio, Alonso-Hernandez, Angel, Alonso, Manuel, Bernabeu, Purificacion, Bernal, Gabriel, Breda, Alberto, Cabello, Mercedes, Luis Caro-Oleas, Jose, Cid, Joan, Diekmann, Fritz, Espinosa, Laura, Facundo, Carme, Garcia, Marta, Gil-Vernet, Salvador, Lozano, Miquel, Mahillo, Beatriz, Jose Martinez, Maria, Miranda, Blanca, Oppenheimer, Federico, Palou, Eduard, Jose Perez-Saez, Maria, Peri, Lluis, Rodriguez, Oscar, Santiago, Carlos, Tabernero, Guadalupe, Hernandez, Domingo, Dominguez-Gil, Beatriz, Pascual, Julio, [Frutos, Miguel Angel] Hosp Reg Univ Malaga, Serv Nefrol, Malaga, Spain, [Alonso, Juana] Hosp Reg Univ Malaga, Serv Nefrol, Malaga, Spain, [Cabello, Mercedes] Hosp Reg Univ Malaga, Serv Nefrol, Malaga, Spain, [Hernandez, Domingo] Hosp Reg Univ Malaga, Serv Nefrol, Malaga, Spain, [Crespo, Marta] Hosp Mar, Serv Nefrol, Barcelona, Spain, [Redondo, Dolores] Hosp Mar, Serv Nefrol, Barcelona, Spain, [Jose Perez-Saez, Maria] Hosp Mar, Serv Nefrol, Barcelona, Spain, [Pascual, Julio] Hosp Mar, Serv Nefrol, Barcelona, Spain, [de la Oliva Valentin, Maria] Org Nacl Trasplantes, Madrid, Spain, [Garcia, Marta] Org Nacl Trasplantes, Madrid, Spain, [Mahillo, Beatriz] Org Nacl Trasplantes, Madrid, Spain, [Dominguez-Gil, Beatriz] Org Nacl Trasplantes, Madrid, Spain, [Alonso-Melgar, Angel] Hosp La Paz, Serv Nefrol Pediat, Madrid, Spain, [Espinosa, Laura] Hosp La Paz, Serv Nefrol Pediat, Madrid, Spain, [Fernandez, Constantino] Hosp Univ A Coruna, Serv Nefrol, La Coruna, Spain, [Alonso-Hernandez, Angel] Hosp Univ A Coruna, Serv Nefrol, La Coruna, Spain, [Garcia-Erauzkin, Gorka] Hosp Univ Cruces, Serv Nefrol, Bilbao, Spain, [Gonzalez, Esther] Hosp Univ 12 Octubre, Serv Nefrol, Madrid, Spain, [Gonzalez-Rinne, Ana M.] Hosp Univ Canarias, Serv Nefrol, Santa Cruz De Tenerife, Spain, [Guirado, Lluis] Fundacio Puigvert, Serv Nefrol, Barcelona, Spain, [Facundo, Carme] Fundacio Puigvert, Serv Nefrol, Barcelona, Spain, [Gutierrez-Dalmau, Alex] Hosp Univ Miguel Seruet, Serv Nefrol, Zaragoza, Spain, [Huguet, Jorge] Fundacio Puigvert, Equipo Quirurg TR, Barcelona, Spain, [Breda, Alberto] Fundacio Puigvert, Equipo Quirurg TR, Barcelona, Spain, [Rodriguez, Oscar] Fundacio Puigvert, Equipo Quirurg TR, Barcelona, Spain, [Lopez del Moral, Jose Luis] Magistrado Tribunal Super Justicia Cantabria, Cantabria, Spain, [Musquera, Mireia] Hosp Clin Univ, Serv Urol, Barcelona, Spain, [Alcaraz, Antonio] Hosp Clin Univ, Serv Urol, Barcelona, Spain, [Peri, Lluis] Hosp Clin Univ, Serv Urol, Barcelona, Spain, [Paredes, David] Hosp Clin Univ, Secc Donac & Coordinac Trasplantes, Barcelona, Spain, [Revuelta, Ignacio] Hosp Clin Univ, Serv Nefrol & TR, Barcelona, Spain, [Diekmann, Fritz] Hosp Clin Univ, Serv Nefrol & TR, Barcelona, Spain, [Oppenheimer, Federico] Hosp Clin Univ, Serv Nefrol & TR, Barcelona, Spain, [Van-der Hofstadt, Carlos J.] Hosp Gen Univ Alicante, Unidad Psicol Hosp, Alicante, Spain, [Bernabeu, Purificacion] Hosp Gen Univ Alicante, Unidad Psicol Hosp, Alicante, Spain, [Alonso, Manuel] Coordinac Autonom Trasplantes, Seville, Spain, [Bernal, Gabriel] Hosp Univ Virgen Rocio, Serv Nefrol, Seville, Spain, [Luis Caro-Oleas, Jose] Hosp Clin & Univ, Serv Inmunol, Barcelona, Spain, [Palou, Eduard] Hosp Clin & Univ, Serv Inmunol, Barcelona, Spain, [Cid, Joan] Hosp Clin Univ, Serv Hemoterapia & Hemostasia, Unidad Aferesis & Terapia Celular, Barcelona, Spain, [Lozano, Miquel] Hosp Clin Univ, Serv Hemoterapia & Hemostasia, Unidad Aferesis & Terapia Celular, Barcelona, Spain, [Gil-Vernet, Salvador] Hosp Univ Bellvitge, Serv Nefrol, Barcelona, Spain, [Jose Martinez, Maria] Hosp Univ La Paz, Serv Urol Pediat, Madrid, Spain, [Miranda, Blanca] Fdn Renal Inigo Alvarez Toledo, Madrid, Spain, [Santiago, Carlos] Hosp Gen Alicante, Serv Nefrol, Alicante, Spain, and [Tabernero, Guadalupe] Hosp Univ Salamanca, Serv Nefrol, Salamanca, Spain
Subjects: Stage renal-disease, Coated mycophenolate sodium, Positive cross-match, Glomerular-filtration-rate, Antilymphocyte induction therapy, Antibody-mediated rejection, Intravenous immune globulin, Rabbit antithymocyte globulin, Antigen-specific immunoadsorption, Term-follow-up
Abstract: This guide for living donor renal transplantation (LDRT) has been prepared with the sponsorship of the Spanish Society of Nephrology (SEN), the Spanish Transplant Society (SET), and the Spanish National Transplant Organization (ONT). It updates evidence to offer the best chronic renal failure treatment when a potential living donor is available. The core aim of this guide is to supply clinicians who evaluate living donors and transplant recipients with the best decision-making tools, to optimise their outcomes. Moreover, the role of living donors in the current RT context should recover the level of importance it had until recently. To this end the new forms of incompatible HLA and/or ABO donation, as well as the paired donation which is possible in several hospitals with experience in LDRT, offer additional ways to treat renal patients with an incompatible donor. Good results in terms of patient and graft survival have expanded the range of circumstances under which living renal donors are accepted. Older donors are now accepted, as are others with factors that affect the decision, such as a borderline clinical history or alterations, which when evaluated may lead to an additional number of transplantations. This guide does not forget that LDRT may lead to risk for the donor. Pre-donation evaluation has to centre on the problems which may arise over the short or long-term, and these have to be described to the potential donor so that they are able to take them into account. Experience over recent years has led to progress in risk analysis, to protect donors' health. This aspect always has to be taken into account by LDRT programmes when evaluating potential donors. Finally, this guide has been designed to aid decision-making, with recommendations and suggestions when uncertainties arise in pre-donation studies. Its overarching aim is to ensure that informed consent is based on high quality studies and information supplied to donors and recipients, offering the strongest possible guarantees. (C) 2021 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Nefrologia.
Published: 2022

27. Monoclonal Gammopathy of Renal Significance in Kidney Transplantation: De Novo C3 Glomerulonephritis

Author: Serra, Nuria, Facundo, Carme, Canal, Cristina, Bardaji, Beatriz, Silva, Irene, Arce, Yolanda, Ayasreh, Nadia, Ballarin, Jose, and Guirado, Lluis
Published: 2018
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28. Biomarkers: New Tool to Detect Subclinical Inflammation?

Author: Serra, Nuria, Bardaji, Beatriz B, Millan, Olga O, Facundo, Carme C, Canal, Cristina C, Silva, Irene I, Arce, Yolanda Y, Guirado, Lluis LL, and Brunet, Merce M
Published: 2018
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29. A comparative study of patient mortality during first and second waves of COVID-19 pandemic in dialysis patients and kidney transplant recipients

Author: Vart, Priya, Jager, Kitty J., Arnol, Miha, Duivenvoorden, Raphael, Franssen, Casper F. M., Groeneveld, Marc, Hemmelder, Marc H., Lepeytre, Fanny, Malfait, Thomas, Midtvedt, Karsten, Mitra, Sandip, Facundo, Carme, Noordzij, Marlies, Reina, Carlos C., Safak, Seda, Toapanta, Nestor, Hilbrands, Luuk B., Gansevoort, Ron T., Groningen Kidney Center (GKC), and Cardiovascular Centre (CVC)
Published: 2022

30. Clinical, Functional, and Mental Health Outcomes in Kidney Transplant Recipients 3 Months After a Diagnosis of COVID-19

Author: Duivenvoorden, Raphaël, Vart, Priya, Noordzij, Marlies, Soares Dos Santos, Augusto C., Zulkarnaev, Alex B., Franssen, Casper F. M., Kuypers, Dirk, Demir, Erol, Rahimzadeh, Hormat, Kerschbaum, Julia, Jager, Kitty J., Turkmen, Kultigin, Hemmelder, Marc H., Schouten, Marcel, Rodríguez-Ferrero, María Luisa, Crespo, Marta, Gansevoort, Ron T., Hilbrands, Luuk B., van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Maas, Nanda, Vogt, Liffert, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Montero Perez, Nuria, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Hengst, Maaike, Konings, Constantijn, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G., Radulescu, Daniela, Zakharova, Elena V., Ambuehl, Patrice Max, Guidotti, Rebecca, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Strazmester Majstorovic, Gordana, Katicic, Dajana, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J. P., Abd Elhafeez, Samar, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Hesselink, Dennis A., Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, el-Wakil, Hala S., Verhoeven, Martine, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Polyzou Konsta, Maria Anna, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Nistor, Ionut, Covic, Adrian, Groeneveld, J. H. M., Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Assis Pereira, Tiago, Arias-Cabrales, Carlos, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M., Siezenga, Machiel A., Franco, Antonio, Arroyo, David, Castellano, Sandra, Balda Manzanos, Sagrario, Sosa Barrios, R. Haridian, Lemahieu, Wim, Bartelet, Karlijn, Burak Dirim, Ahmet, Sukru Sever, Mehmet, Turkmen, Aydin, Şafak, Seda, Hollander, Daan A. M. J., Büttner, Stefan, de Vries, Aiko P. J., Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petruliene, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Mohan Kumar, N., di Luca, Marina, Tuǧlular, Serhan Z., Kramer, Andrea, Beerenhout, Charles, Luik, Peter T., Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y., Stepanov, Vadim A., Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, van de Logt, Anne Els, Maas, Rutger, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J. M., Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rychlik, Ivan, Cabezas-Reina, Carlos J., Maria Roca, Ana, Nauta, Ferdau, Sahin, İdris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K. I., Naesens, Maarten, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M., Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P., Meijer, Esther, Sanders, Jan Stephan F., Özyilmaz, Akin, Buturović Ponikvar, Jadranka, Marn Pernat, Andreja, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C., Molenaar, Femke M., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Tantisattamo, Ekamol, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Jose Soler, Maria, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimsevicius, Laurynas, Righetti, Marco, Islam, Mahmud, Heitink-ter Braak, Nicole, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Medical Informatics, ACS - Pulmonary hypertension & thrombosis, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, Nephrology, ACS - Diabetes & metabolism, Internal Medicine, Interne Geneeskunde, RS: Carim - V02 Hypertension and target organ damage, and Clinical sciences
Subjects: kidney transplant, Adult, Kidney Disease, Outcome Assessment, Renal and urogenital, infectious diseases, Medical and Health Sciences, clinical, DISEASE, All institutes and research themes of the Radboud University Medical Center, Rare Diseases, SDG 3 - Good Health and Well-being, 7.1 Individual care needs, Clinical Research, Outcome Assessment, Health Care, Humans, Retrospective Studies, Transplantation, SARS-CoV-2, MORTALITY, Rehabilitation, COVID-19, mental health outcomes, survive, Organ Transplantation, Original Clinical Science—General, Middle Aged, SOLID-ORGAN TRANSPLANT, Kidney Transplantation, Transplant Recipients, DIALYSIS PATIENTS, Health Care, functional, Intensive Care Units, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Good Health and Well Being, Nephrology, ERACODA, ERACODA Collaborators, Surgery, Management of diseases and conditions, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract: BACKGROUND: Kidney transplant patients are at high risk for coronavirus disease 2019 (COVID-19)-related mortality. However, limited data are available on longer-term clinical, functional, and mental health outcomes in patients who survive COVID-19.METHODS: We analyzed data from adult kidney transplant patients in the European Renal Association COVID-19 Database who presented with COVID-19 between February 1, 2020, and January 31, 2021.RESULTS: We included 912 patients with a mean age of 56.7 (±13.7) y. 26.4% were not hospitalized, 57.5% were hospitalized without need for intensive care unit (ICU) admission, and 16.1% were hospitalized and admitted to the ICU. At 3 mo follow-up survival was 82.3% overall, and 98.8%, 84.2%, and 49.0%, respectively, in each group. At 3 mo follow-up biopsy-proven acute rejection, need for renal replacement therapy, and graft failure occurred in the overall group in 0.8%, 2.6%, and 1.8% respectively, and in 2.1%, 10.6%, and 10.6% of ICU-admitted patients, respectively. Of the surviving patients, 83.3% and 94.4% reached their pre-COVID-19 physician-reported functional and mental health status, respectively, within 3 mo. Of patients who had not yet reached their prior functional and mental health status, their treating physicians expected that 79.6% and 80.0%, respectively, still would do so within the coming year. ICU admission was independently associated with a low likelihood to reach prior functional and mental health status.CONCLUSIONS: In kidney transplant recipients alive at 3-mo follow-up, clinical, physician-reported functional, and mental health recovery was good for both nonhospitalized and hospitalized patients. Recovery was, however, less favorable for patients who had been admitted to the ICU.
Published: 2022

31. A Prospective Multicenter Trial to Evaluate Urinary Metabolomics for Non-invasive Detection of Renal Allograft Rejection (PARASOL) : Study Protocol and Patient Recruitment

Author: Banas, Miriam C., Böhmig, Georg A., Viklicky, Ondrej, Rostaing, Lionel P., Jouve, Thomas, Guirado, Luis, Facundo, Carme, Bestard, Oriol, Gröne, Hermann-Josef, Kobayashi, Kazuhiro, Hanzal, Vladimir, Putz, Franz Josef, Zecher, Daniel, Bergler, Tobias, Neumann, Sindy, Rothe, Victoria, Schwäble Santamaria, Amauri G., Schiffer, Eric, Banas, Bernhard, Universitat Autònoma de Barcelona, Banas, Miriam C., Böhmig, Georg A., Viklicky, Ondrej, Rostaing, Lionel P., Jouve, Thomas, Guirado, Luis, Facundo, Carme, Bestard, Oriol, Gröne, Hermann-Josef, Kobayashi, Kazuhiro, Hanzal, Vladimir, Putz, Franz Josef, Zecher, Daniel, Bergler, Tobias, Neumann, Sindy, Rothe, Victoria, Schwäble Santamaria, Amauri G., Schiffer, Eric, Banas, Bernhard, and Universitat Autònoma de Barcelona
Abstract: Background: In an earlier monocentric study, we have developed a novel non-invasive test system for the prediction of renal allograft rejection, based on the detection of a specific urine metabolite constellation. To further validate our results in a large real-world patient cohort, we designed a multicentric observational prospective study (PARASOL) including six independent European transplant centers. This article describes the study protocol and characteristics of recruited better patients as subjects. Methods: Within the PARASOL study, urine samples were taken from renal transplant recipients when kidney biopsies were performed. According to the Banff classification, urine samples were assigned to a case group (renal allograft rejection), a control group (normal renal histology), or an additional group (kidney damage other than rejection). Results: Between June 2017 and March 2020, 972 transplant recipients were included in the trial (1,230 urine samples and matched biopsies, respectively). Overall, 237 samples (19.3%) were assigned to the case group, 541 (44.0%) to the control group, and 452 (36.7%) samples to the additional group. About 65.9% were obtained from male patients, the mean age of transplant recipients participating in the study was 53.7 ± 13.8 years. The most frequently used immunosuppressive drugs were tacrolimus (92.8%), mycophenolate mofetil (88.0%), and steroids (79.3%). Antihypertensives and antidiabetics were used in 88.0 and 27.4% of the patients, respectively. Approximately 20.9% of patients showed the presence of circulating donor-specific anti-HLA IgG antibodies at time of biopsy. Most of the samples (51.1%) were collected within the first 6 months after transplantation, 48.0% were protocol biopsies, followed by event-driven (43.6%), and follow-up biopsies (8.5%). Over time the proportion of biopsies classified into the categories Banff 4 (T-cell-mediated rejection [TCMR]) and Banff 1 (normal tissue) decreased whereas Banff 2 (antibody-m
Published: 2022

32. Immunoguided Discontinuation of Prophylaxis for Cytomegalovirus Disease in Kidney Transplant Recipients Treated With Antithymocyte Globulin: A Randomized Clinical Trial

Author: Instituto de Salud Carlos III, Sociedad Española de Nefrología, Red Española de Investigación en Patología Infecciosa, European Commission, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (España), Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, Páez-Vega, Aurora, Gutiérrez-Gutiérrez, Belén, Agüera, María L., Facundo, Carme, Redondo, Dolores, Suñer, Marta, López‐Oliva, María O., Yuste, José Ramón, Montejo, Miguel, Galeano-Álvarez, Cristina, Ruiz San Millán, Juan Carlos, Los-Arcos, Ibai, Hernández, Domingo, Fernández-Ruiz, Mario, Muñoz, Patricia, Valle-Arroyo, Jorge, Cano, Ángela, Rodríguez-Benot, Alberto, Crespo, Marta, Rodelo-Haad, Cristian, Lobo Acosta, María Ángeles, Garrido-Gracia, José Carlos, Vidal, Elisa, Guirado, Luis, Cantisán, Sara, Torre-Cisneros, Julián, TIMOVAL Study Group, Instituto de Salud Carlos III, Sociedad Española de Nefrología, Red Española de Investigación en Patología Infecciosa, European Commission, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (España), Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, Páez-Vega, Aurora, Gutiérrez-Gutiérrez, Belén, Agüera, María L., Facundo, Carme, Redondo, Dolores, Suñer, Marta, López‐Oliva, María O., Yuste, José Ramón, Montejo, Miguel, Galeano-Álvarez, Cristina, Ruiz San Millán, Juan Carlos, Los-Arcos, Ibai, Hernández, Domingo, Fernández-Ruiz, Mario, Muñoz, Patricia, Valle-Arroyo, Jorge, Cano, Ángela, Rodríguez-Benot, Alberto, Crespo, Marta, Rodelo-Haad, Cristian, Lobo Acosta, María Ángeles, Garrido-Gracia, José Carlos, Vidal, Elisa, Guirado, Luis, Cantisán, Sara, Torre-Cisneros, Julián, and TIMOVAL Study Group
Abstract: [Background] Antiviral prophylaxis is recommended in cytomegalovirus (CMV)-seropositive kidney transplant (KT) recipients receiving antithymocyte globulin (ATG) as induction. An alternative strategy of premature discontinuation of prophylaxis after CMV-specific cell-mediated immunity (CMV-CMI) recovery (immunoguided prevention) has not been studied. Our aim was to determine whether it is effective and safe to discontinue prophylaxis when CMV-CMI is detected and to continue with preemptive therapy., [Methods] In this open-label, noninferiority clinical trial, patients were randomized 1:1 to follow an immunoguided strategy, receiving prophylaxis until CMV-CMI recovery or to receive fixed-duration prophylaxis until day 90. After prophylaxis, preemptive therapy (valganciclovir 900 mg twice daily) was indicated in both arms until month 6. The primary and secondary outcomes were incidence of CMV disease and replication, respectively, within the first 12 months. Desirability of outcome ranking (DOOR) assessed 2 deleterious events (CMV disease/replication and neutropenia)., [Results] A total of 150 CMV-seropositive KT recipients were randomly assigned. There was no difference in the incidence of CMV disease (0% vs 2.7%; P = .149) and replication (17.1% vs 13.5%; log-rank test, P = .422) between both arms. Incidence of neutropenia was lower in the immunoguided arm (9.2% vs 37.8%; odds ratio, 6.0; P < .001). A total of 66.1% of patients in the immunoguided arm showed a better DOOR, indicating a greater likelihood of a better outcome., [Conclusions] Prophylaxis can be prematurely discontinued in CMV-seropositive KT patients receiving ATG when CMV-CMI is recovered since no significant increase in the incidence of CMV replication or disease is observed.
Published: 2022

33. MO495: A Comparative Study of Patient Mortality During First and Second Waves of Covid-19 Pandemic in Dialysis Patients and Kidney Transplant Recipients

Author: Vart, Priya, primary, Jager, Kitty J, additional, Arnol, Miha, additional, Duivenvoorden, Raphaël, additional, Franssen, Casper F M, additional, Groeneveld, Marc, additional, Hemmelder, Marc H, additional, Lepeytre, Fanny, additional, Malfait, Thomas, additional, Midtvedt, Karsten, additional, Mitra, Sandip, additional, Facundo, Carme, additional, Noordzij, Marlies, additional, Reina, Carlos C, additional, Safak, Seda, additional, Toapanta, Nestor, additional, Hilbrands, Luuk B, additional, and Gansevoort, Ron T, additional
Published: 2022
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34. V05-01 3D AUGMENTED REALITY-GUIDED ROBOTIC-ASSISTED KIDNEY TRANSPLANTATION: REVEALING THE CONCEALED

Author: Piana, Alberto, primary, Andrea, Gallioli, additional, Diana, Pietro, additional, Territo, Angelo, additional, Gaya, Josep Maria, additional, Gavrilov, Pavel, additional, Faba, Óscar Rodriguez, additional, Huguet, Jordi, additional, Guirado, Lluis, additional, Facundo, Carme, additional, Campi, Riccardo, additional, Bellin, Andrea, additional, Amparore, Daniele, additional, Serni, Sergio, additional, Palou, Joan, additional, and Breda, Alberto, additional
Published: 2022
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35. Induction immunosuppression and outcome in kidney transplant recipients with early COVID-19 after transplantation

Author: Toapanta, Néstor, primary, Jiménez, Sara, additional, Molina-Gómez, María, additional, Maruri-Kareaga, Naroa, additional, Llinàs-Mallol, Laura, additional, Villanego, Florentino, additional, Facundo, Carme, additional, Rodríguez-Ferrero, Marisa, additional, Montero, Nuria, additional, Vázquez-Sanchez, Teresa, additional, Gutiérrez-Dalmau, Alex, additional, Beneyto, Isabel, additional, Franco, Antonio, additional, Hernández-Vicente, Ana, additional, Pérez-Tamajon, M Lourdes, additional, Martin, Paloma, additional, Ramos-Verde, Ana María, additional, Castañeda, Zaira, additional, Bestard, Oriol, additional, and Moreso, Francesc, additional
Published: 2022
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36. Manejo de la inmunosupresión en pacientes trasplantados de riñón con COVID19. Estudio multicéntrico nacional derivado del registro COVID de la S.E.N

Author: López-Oliva, María O., primary, Pérez-Flores, Isabel, additional, Molina, María, additional, José Aladrén, Mª, additional, Trujillo, Hernando, additional, Redondo-Pachón, Dolores, additional, López, Verónica, additional, Facundo, Carme, additional, Villanego, Florentino, additional, Rodríguez, Marisa, additional, Carmen Ruiz, Mª, additional, Antón, Paula, additional, Rivas-Oural, Alba, additional, Cabello, Sheila, additional, Portolés, José, additional, de la Vara, Lourdes, additional, Tabernero, Guadalupe, additional, Valero, Rosalía, additional, Galeano, Cristina, additional, Moral, Esperanza, additional, Ventura, Ana, additional, Coca, Armando, additional, Muñoz, Miguel Ángel, additional, Hernández-Gallego, Román, additional, Shabaka, Amir, additional, Ledesma, Gabriel, additional, Martínez, Patricia, additional, Ángeles Rodríguez, Mª, additional, Tamajón, Lourdes Pérez, additional, Cruzado, Leónidas, additional, Emilio Sánchez, J., additional, and Jiménez, Carlos, additional
Published: 2022
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37. Trasplante renal de donante vivo. Análisis de situación y hoja de ruta

Author: Oliva Valentín, María de la, Hernández, Domingo, Crespo, Marta, Mahillo, Beatriz, Beneyto, Isabel, Martínez, Itziar, Kanter, Julia, Calderari, Elena, Gil-Vernet, Salvador, Sánchez, Sara, Agüera, María Luisa, Bernal, Gabriel, De Santiago, Carlos, Díaz-Corte, Carmen, Díaz, Cándido, Espinosa, Laura, Facundo, Carme, Fernández-Lucas, Milagros, Ferreiro, Tamara, Ruiz San Millán, Juan Carlos, and Universidad de Cantabria
Subjects: Benchmarking, Optimización de la donación de vivo, Proceso de donación de vivo, Trasplante renal de donante vivo, Autoevaluación del proceso de donación de vivo, Evolución donación de vivo, Tratamiento de la enfermedad renal crónica avanzada
Abstract: El trasplante renal de donante vivo (TRDV) es la opción terapéutica con las mejores expectativas de supervivencia para el injerto y para el paciente con insuficiencia renal terminal; sin embargo, este tipo de trasplantes ha experimentado un descenso progresivo en los últimos años en España. Entre las posibles explicaciones del descenso de actividad se encuentra la coincidencia en el tiempo con un aumento en el número de donantes renales fallecidos, tanto por muerte encefálica como por asistolia controlada, que podría haber generado una falsa impresión de ausencia de necesidad del TRDV. Además, la disponibilidad de un mayor número de riñones para trasplante habría supuesto un incremento en la carga de trabajo de los profesionales que pudiera enlentecer los procesos de donación en vida. Otro posible argumento radica en un posible cambio de actitud hacia posturas más conservadoras a la hora de informar a pacientes y a familiares acerca de esta opción terapéutica, a raíz de los artículos publicados respecto al riesgo de la donación a largo plazo. Sin embargo, existe una importantísima variabilidad en la actividad entre centros y comunidades autónomas, no explicada por el volumen de trasplante procedente de otros tipos de donante. Este dato, unido a que la indicación de donación renal en vida se realiza de manera mayoritaria en situación de enfermedad renal crónica avanzada (ERCA) y que el tiempo en diálisis es un factor pronóstico negativo respecto a la supervivencia postrasplante, permite concluir que el descenso depende además de otros factores. Por este motivo, en la reunión anual de equipos de trasplante renal, celebrada en la sede de la Organización Nacional de Trasplantes (ONT) en 2018, se constituyó un grupo de trabajo formado por equipos de trasplante renal, el grupo de trasplantes de la Sociedad Española de Nefrología (SEN) (SENTRA), la Sociedad Española de Trasplantes (SET) y la ONT, con el objetivo de identificar otras causas que condicionaron el descenso de la actividad de este tipo de trasplantes en España y su posible relación con la gestión del proceso de donación de vivo. El grupo de trabajo diseñó un cuestionario de autoevaluación, que fue cumplimentado por las 33 unidades de trasplante renal de donante vivo activas en España. El cuestionario contiene preguntas sobre las diferentes fases del proceso de donación de vivo: información inicial, estudio del donante vivo e información de los riesgos, consentimiento, recursos humanos (RRHH), nefrectomía, trasplante y seguimiento posterior. El análisis de las respuestas ha dado como resultado la creación de un análisis de debilidades, amenazas, fortalezas y oportunidades (DAFO) del programa a nivel nacional y ha permitido elaborar recomendaciones específicas dirigidas a mejorar cada una de las fases del proceso de donación en vida. El documento, denominado Análisis de situación del trasplante renal de donante vivo y hoja de ruta ha sido también revisado por un panel de expertos en TRDV, representantes de varias sociedades científicas implicadas (Asociación Española de Urología [AEU], Sociedad Española de Enfermería Nefrológica [SEDEN], Sociedad Española de Inmunología [SEI/GETH]), el Grupo de Trabajo Enfermedad Renal Crónica Avanzada (ACERCA), la Asociación de Pacientes para la Lucha Contra la Enfermedad Renal (ALCER) y sometido posteriormente a consulta pública. Tras incluir las mejoras sugeridas, el documento final ha sido adoptado institucionalmente en el Consejo Interterritorial de Trasplantes (CIT) del Sistema Nacional de Salud. El trabajo realizado y las recomendaciones para optimizar el TRVD se describen a lo largo del presente artículo, organizados por los diferentes apartados del proceso de donación. Living donor kidney transplantation (LDKT) is the best treatment option for end stage renal disease in terms of both patient and graft survival. However, figures on LDKT in Spain that had been continuously growing from 2005 to 2014, have experienced a continuous decrease in the last five years. One possible explanation for this decrease is that the significant increase in the number of deceased donors in Spain during the last years, both brain death and controlled circulatory death donors, might have generated the false idea that we have coped with the transplant needs. Moreover, a greater number of deceased donor kidney transplants have caused a heavy workload for the transplant teams. Furthermore, the transplant teams could have moved on to a more conservative approach to the information and assessment of patients and families considering the potential long-term risks for donors in recent papers. However, there is a significant variability in the LDKT rate among transplant centers and regions in Spain independent of their deceased donor rates. This fact and the fact that LDKT is usually a preemptive option for patients with advanced chronic renal failure, as time on dialysis is a negative independent factor for transplant outcomes, lead us to conclude that the decrease in LDKT depends on other factors. Thus, in the kidney transplant annual meeting held at ONT site in 2018, a working group was created to identify other causes for the decrease of LDKT in Spain and its relationship with the different steps of the process. The group was formed by transplant teams, a representative of the transplant group of the Spanish Society of Nephrology (SENTRA), a representative of the Spanish Society of Transplants (SET) and representatives of the Spanish National Transplant Organization (ONT). A self-evaluation survey that contains requests about the phases of the LDKT processes (information, donor work out, informed consent, surgeries, follow-up and human resources) were developed and sent to 33 LDKT teams. All the centers answered the questionnaire. The analysis of the answers has resulted in the creation of a national analysis of strengths, weaknesses, opportunities, threats (SWOT) of the LDKT program in Spain and the development of recommendations targeted to improve every step of the donation process. The work performed, the conclusions and recommendations provided, have been reflected in the following report: Spanish living donor kidney transplant program assessment: recommendations for optimization. This document has also been reviewed by a panel of experts, representatives of the scientific societies (Spanish Society of Urology (AEU), Spanish Society of Nephrology Nursery (SEDEN), Spanish Society of Immunology (SEI/GETH)) and the patient association ALCER. Finally, the report has been submitted to public consultation, reaching ample consensus. In addition, the transplant competent authorities of the different regions in Spain have adopted the report at institutional level. The work done and the recommendations to optimize LDKT are summarized in the present manuscript, organized by the different phases of the donation process.
Published: 2022

38. A Prospective Multicenter Trial to Evaluate Urinary Metabolomics for Non-invasive Detection of Renal Allograft Rejection (PARASOL): Study Protocol and Patient Recruitment

Author: Banas, Miriam C., primary, Böhmig, Georg A., additional, Viklicky, Ondrej, additional, Rostaing, Lionel P., additional, Jouve, Thomas, additional, Guirado, Lluis, additional, Facundo, Carme, additional, Bestard, Oriol, additional, Gröne, Hermann-Josef, additional, Kobayashi, Kazuhiro, additional, Hanzal, Vladimir, additional, Putz, Franz Josef, additional, Zecher, Daniel, additional, Bergler, Tobias, additional, Neumann, Sindy, additional, Rothe, Victoria, additional, Schwäble Santamaria, Amauri G., additional, Schiffer, Eric, additional, and Banas, Bernhard, additional
Published: 2022
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39. Evaluación de un programa docente en trasplante renal de donación de vivo dirigido a profesionales

Author: Alonso, Maria Teresa, López, Maite, Palomino, Ana, Franquet, Esther, Facundo, Carme, and Breda, Alberto
Published: 2021

40. Deciphering transplant outcomes of expanded kidney allografts donated after controlled circulatory death in the current transplant era. A call for caution

Author: Montero, Nuria, primary, Toapanta, Néstor, additional, Pallarès, Natàlia, additional, Crespo, Marta, additional, Diekmann, Fritz, additional, Guirado, Lluis, additional, Esteban, Rafael, additional, Codina, Sergi, additional, Melilli, Edoardo, additional, Buxeda, Anna, additional, Velis, Gonzalo, additional, Torres, Irina B., additional, Revuelta, Ignacio, additional, Molina Andujar, Alicia, additional, Facundo, Carme, additional, Bardají, Beatriz, additional, Riera, Lluís, additional, Fiol, Maria, additional, Cruzado, Josep M., additional, Comas, Jordi, additional, Giral, Magali, additional, Naesens, Maarten, additional, Åsberg, Anders, additional, Moreso, Francesc, additional, and Bestard, Oriol, additional
Published: 2021
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41. PD45-05 STEP-BY-STEP DEVELOPMENT OF A COLD ISCHEMIA DEVICE FOR OPEN AND ROBOT-ASSISTED RENAL TRANSPLANTATION

Author: Territo, Angelo, primary, Fontana, Matteo, additional, Gallioli, Andrea, additional, Piana, Alberto, additional, Diana, Pietro, additional, Gaya, José Maria, additional, Huguet, Jorge, additional, Gavrilov, Pavel, additional, Faba, Oscar Rodriguez, additional, Mottrie, Alex, additional, Facundo, Carme, additional, Guirado, Lluís, additional, Palou, Joan, additional, and Breda, Alberto, additional
Published: 2021
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42. V02-01 NEW TECHNOLOGIES IN ROBOT-ASSISTED KIDNEY TRANSPLANTATION: IMPROVING SURGICAL PERFORMANCES, EXPANDING THE INDICATION

Author: Piana, Alberto, primary, Territo, Angelo, additional, Gallioli, Andrea, additional, Fontana, Matteo, additional, Diana, Pietro, additional, Gaya, José Maria, additional, Faba, Oscar Rodriguez, additional, Huguet, Jorge, additional, Gavrilov, Pavel, additional, Mercadé, Asier, additional, Subiela, Jose Daniel, additional, Guirado, Lluís, additional, Facundo, Carme, additional, Bellin, Andrea, additional, Amparore, Daniele, additional, Palou, Joan, additional, Porpiglia, Francesco, additional, and Breda, Alberto, additional
Published: 2021
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43. COVID-19-related Mortality During the First 60 Days After Kidney Transplantation

Author: Pascual, Julio, Melilli, Edoardo, Jiménez-Martín, Carlos, González-Monte, Esther, Zárraga, Sofía, Gutiérrez-Dalmau, Alex, López-Jiménez, Veronica, Juega, Javier, Muñoz-Cepeda, Miguel, Lorenzo, Inmaculada, Facundo, Carme, Ruiz-Fuentes, María Del Carmen, Mazuecos, Auxiliadora, Sánchez-Álvarez, Emilio, Crespo, Marta, and Spanish Society of Nephrology COVID-19 Group
Subjects: Adult, Male, medicine.medical_specialty, Time Factors, Coronavirus disease 2019 (COVID-19), Urology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, MEDLINE, Opportunistic Infections, Risk Assessment, Article, Betacoronavirus, Immunocompromised Host, Risk Factors, Internal medicine, Pandemic, medicine, Humans, Registries, Viral immunology, Pandemics, Kidney transplantation, Aged, business.industry, SARS-CoV-2, COVID-19, Middle Aged, medicine.disease, Kidney Transplantation, Pneumonia, Treatment Outcome, Spain, Host-Pathogen Interactions, Female, Risk assessment, business, Coronavirus Infections, Immunosuppressive Agents
Published: 2020

44. Immunoguided Discontinuation of Prophylaxis for Cytomegalovirus Disease in Kidney Transplant Recipients Treated With Antithymocyte Globulin: A Randomized Clinical Trial.

Author: Páez-Vega, Aurora, Gutiérrez-Gutiérrez, Belén, Agüera, Maria L, Facundo, Carme, Redondo-Pachón, Dolores, Suñer, Marta, López-Oliva, Maria O, Yuste, Jose R, Montejo, Miguel, Galeano-Álvarez, Cristina, Millan, Juan C Ruiz-San, Los-Arcos, Ibai, Hernández, Domingo, Fernández-Ruiz, Mario, Muñoz, Patricia, Valle-Arroyo, Jorge, Cano, Angela, Rodríguez-Benot, Alberto, Crespo, Marta, and Rodelo-Haad, Cristian
Subjects: CYTOMEGALOVIRUS diseases, LOG-rank test, KIDNEY transplantation, ANTILYMPHOCYTIC serum, ANTIVIRAL agents, NEUTROPENIA, TREATMENT effectiveness, RANDOMIZED controlled trials, IMMUNITY, DESCRIPTIVE statistics, TERMINATION of treatment, STATISTICAL sampling, ODDS ratio, TRANSPLANTATION of organs, tissues, etc., EVALUATION
Abstract: Background Antiviral prophylaxis is recommended in cytomegalovirus (CMV)-seropositive kidney transplant (KT) recipients receiving antithymocyte globulin (ATG) as induction. An alternative strategy of premature discontinuation of prophylaxis after CMV-specific cell-mediated immunity (CMV-CMI) recovery (immunoguided prevention) has not been studied. Our aim was to determine whether it is effective and safe to discontinue prophylaxis when CMV-CMI is detected and to continue with preemptive therapy. Methods In this open-label, noninferiority clinical trial, patients were randomized 1:1 to follow an immunoguided strategy, receiving prophylaxis until CMV-CMI recovery or to receive fixed-duration prophylaxis until day 90. After prophylaxis, preemptive therapy (valganciclovir 900 mg twice daily) was indicated in both arms until month 6. The primary and secondary outcomes were incidence of CMV disease and replication, respectively, within the first 12 months. Desirability of outcome ranking (DOOR) assessed 2 deleterious events (CMV disease/replication and neutropenia). Results A total of 150 CMV-seropositive KT recipients were randomly assigned. There was no difference in the incidence of CMV disease (0% vs 2.7%; P =.149) and replication (17.1% vs 13.5%; log-rank test, P =.422) between both arms. Incidence of neutropenia was lower in the immunoguided arm (9.2% vs 37.8%; odds ratio, 6.0; P <.001). A total of 66.1% of patients in the immunoguided arm showed a better DOOR, indicating a greater likelihood of a better outcome. Conclusions Prophylaxis can be prematurely discontinued in CMV-seropositive KT patients receiving ATG when CMV-CMI is recovered since no significant increase in the incidence of CMV replication or disease is observed. Clinical Trials Registration NCT03123627. [ABSTRACT FROM AUTHOR]
Published: 2022
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45. THE CHALLENGE OF LIVE KIDNEY DONOR EVALUATION: PERCENTAGE OF EXCLUSIONS: MO-011

Author: Facundo, Carme, Martinez, Maria José, Guirado, Lluis, Díaz, Joan Manuel, Canal, Cristina, and Breda, Alberto
Published: 2011

46. EXPANDED CRITERIA FOR LIVE DONOR NEPHRECTOMY: O-094

Author: Facundo, Carme, Guirado, Luis, Diaz, Juan Manuel, Rosales, Antonio, Fava, Oscar Rodriguz, and Breda, Alberto
Published: 2011

47. COVID-19–related Mortality During the First 60 Days After Kidney Transplantation

Author: Pascual, Julio, primary, Melilli, Edoardo, additional, Jiménez-Martín, Carlos, additional, González-Monte, Esther, additional, Zárraga, Sofía, additional, Gutiérrez-Dalmau, Alex, additional, López-Jiménez, Veronica, additional, Juega, Javier, additional, Muñoz-Cepeda, Miguel, additional, Lorenzo, Inmaculada, additional, Facundo, Carme, additional, Ruiz-Fuentes, María del Carmen, additional, Mazuecos, Auxiliadora, additional, Sánchez-Álvarez, Emilio, additional, and Crespo, Marta, additional
Published: 2020
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48. Cellular Immunity to Predict the Risk of Cytomegalovirus Infection in Kidney Transplantation: A Prospective, Interventional, Multicenter Clinical Trial

Author: Jarque, Marta, primary, Crespo, Elena, primary, Melilli, Edoardo, primary, Gutiérrez, Alex, primary, Moreso, Francesc, primary, Guirado, Lluís, primary, Revuelta, Ignacio, primary, Montero, Nuria, primary, Torras, Joan, primary, Riera, Lluís, primary, Meneghini, Maria, primary, Taco, Omar, primary, Manonelles, Anna, primary, Paul, Javier, primary, Seron, Daniel, primary, Facundo, Carme, primary, Cruzado, Josep M, primary, Gil Vernet, Salvador, primary, Grinyó, Josep M, primary, and Bestard, Oriol, primary
Published: 2020
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49. SARS-CoV-2 in Kidney Transplant Recipients: A Multicentric Prospective Cohort Study

Author: Favà, Alexandre, primary, Montero, Nuria, additional, Cucchiari, David, additional, Toapanta, Nestor, additional, Centellas, Javier, additional, Vila-Santandreu, Anna, additional, Coloma, Ana, additional, Meneghini, Maria, additional, Manonelles, Anna, additional, Sellarès, Joana, additional, Torres, Irina, additional, Gelpi, Rosana, additional, Lorenzo, Immaculada, additional, Ventura-Aguiar, Pedro, additional, Cofan, Frederic, additional, Torregrosa, Vicenç, additional, Perelló, Manel, additional, Facundo, Carme, additional, Moreso, Francesc, additional, Seron, Daniel, additional, Oppenheimer, Federico, additional, Bestard, Oriol, additional, Cruzado, Josep Maria, additional, and Melilli, Edoardo, additional
Published: 2020
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50. Three cases of monoclonal gammopathy of renal significance after kidney transplantation. De novo C3 glomerulopathy

Author: Serra, Núria, primary, Facundo, Carme, additional, Canal, Cristina, additional, Arce, Yolanda, additional, Ayasreh, Nadia, additional, Vila, Anna, additional, Bardají, Beatriz, additional, Silva, Irene, additional, López, Víctor, additional, Benito, Silvia, additional, Ballarín, Jose, additional, and Guirado, Lluís, additional
Published: 2019
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