1. The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs
- Author
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Benilde, Cosmi, Cristina, Legnani, Vittorio, Pengo, Angelo, Ghirarduzzi, Sophie, Testa, Daniela, Poli, Domenico, Prisco, Armando, Tripodi, Gualtiero, Palareti, L, Rota, B. Cosmi, C. Legnani, V. Pengo, A. Ghirarduzzi, S. Testa, D. Poli, D. Prisco, A. Tripodi, and G. Palareti
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Deep vein ,030204 cardiovascular system & hematology ,Thrombophilia ,Gastroenterology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Factor V Leiden ,Humans ,Medicine ,Prospective Studies ,Vascular Diseases ,cardiovascular diseases ,Prospective cohort study ,Factor V/genetics/metabolism ,Aged ,Ultrasonography ,Aged, 80 and over ,Venous Thrombosis ,First episode ,business.industry ,Factor V ,Anticoagulants ,Hematology ,Middle Aged ,medicine.disease ,Thrombosis ,Surgery ,Pulmonary embolism ,Venous thrombosis ,medicine.anatomical_structure ,Lower Extremity ,030220 oncology & carcinogenesis ,Mutation ,Female ,Prothrombin ,business ,Pulmonary Embolism - Abstract
It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptomatic pulmonary embolism (PE). Patients were enrolled in two prospective multicentre studies: PROLONG and PROLONG II. RVO was detected by compression ultrasonography according to the method of Prandoni on the day of anticoagulation withdrawal. Patients were also screened for FVL and FII mutation. The presence of FVL and/or FII mutation was determined in 872/963 (90.5%) patients, in 753 of whom RVO was assessed. FVL was significantly less frequent among subjects with isolated PE (7/176:4%) than among patients with either DVT and PE (15/133:11.3%; p=0.0018) or isolated DVT (89/563:15.8%; p
- Published
- 2013