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The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs
- Publication Year :
- 2013
-
Abstract
- It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptomatic pulmonary embolism (PE). Patients were enrolled in two prospective multicentre studies: PROLONG and PROLONG II. RVO was detected by compression ultrasonography according to the method of Prandoni on the day of anticoagulation withdrawal. Patients were also screened for FVL and FII mutation. The presence of FVL and/or FII mutation was determined in 872/963 (90.5%) patients, in 753 of whom RVO was assessed. FVL was significantly less frequent among subjects with isolated PE (7/176:4%) than among patients with either DVT and PE (15/133:11.3%; p=0.0018) or isolated DVT (89/563:15.8%; p
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Deep vein
030204 cardiovascular system & hematology
Thrombophilia
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Factor V Leiden
Humans
Medicine
Prospective Studies
Vascular Diseases
cardiovascular diseases
Prospective cohort study
Factor V/genetics/metabolism
Aged
Ultrasonography
Aged, 80 and over
Venous Thrombosis
First episode
business.industry
Factor V
Anticoagulants
Hematology
Middle Aged
medicine.disease
Thrombosis
Surgery
Pulmonary embolism
Venous thrombosis
medicine.anatomical_structure
Lower Extremity
030220 oncology & carcinogenesis
Mutation
Female
Prothrombin
business
Pulmonary Embolism
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e1dd15c16a91267a96bae92f819eaa5d