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2,022 results on '"Fac Med"'

1. DIFFERENCES IN POSTNATAL CEREBRAL CAPILLARY GROWTH BETWEEN NORMAL AND PROTEIN DEPRIVED RATS. MORPHOMETRIC STUDIES

Author: Conradi, N., Eins, S., WOLFF, J-R, and Fac, Med.
Published: 1978

2. Doping and sports endocrinology: anabolic-androgenic steroids

Author: Garcia-Arnes, J. A., Garcia-Casares, N., [Garcia-Arnes, J. A.] Univ Malaga, Fac Med, Dept Farmacol, Malaga, Spain, [Garcia-Casares, N.] Univ Malaga, Fac Med, Dept Med, Malaga, Spain, [Garcia-Casares, N.] Univ Malaga, Ctr Invest Med Sanitarias CIMES, Malaga, Spain, and [Garcia-Casares, N.] Inst Invest Biomed Malaga IBIMA, Malaga, Spain
Subjects: Anabolic steroids, Pharmacology, Athletes, Gym, Doping, Prevalence, Testosterone, Therapy, Abuse, Users, Consequences, Androgen
Abstract: The use of anabolic steroids affects not only professional athletes but also the general population (bodybuilders, gym clients, and adolescents). In the first case, its use is prohibited and sanctioned by the World Anti-Doping Agency and Olympic committees. For the other users, it is difficult to establish its prevalence since many obtain the products via the Internet. The reasons for its use are varied and different forms of use and other types of users have been described. Among the side effects of steroid use, hypogonadism is the most frequent cause for endocrinological consultation. After a general introduction to doping, this review describes the historical background of anabolic-androgenic steroids, their classification, forms of use, phy-siological effects, adverse effects on different organs and systems, treatment of hypogonadism, as well as detection methods. (C) 2022 The Authors. Published by Elsevier Espana, S.L.U.
Published: 2022

3. Pan-genomic analysis of Corynebacterium amycolatum gives insights into molecular mechanisms underpinning the transition to a pathogenic phenotype

Author: Jesus, Hendor N. R., Rocha, Danilo J. P. G., Ramos, Rommel T. J., Silva, Artur, Brenig, Bertram, Goes-Neto, Aristoteles, Costa, Mateus M., Soares, Siomar C., Azevedo, Vasco, Aguiar, Eric R. G. R., Martinez-Martinez, Luiz, Ocampo, Alain, Alibi, Sana, Dorta, Alexis, Pacheco, Luis G. C., Navas, Jesus, [Jesus, Hendor N. R.] Univ Fed Bahia, Inst Hlth Sci, Multictr Postgrad Program Biochem & Mol Biol PMBq, Salvador, BA, Brazil, [Pacheco, Luis G. C.] Univ Fed Bahia, Inst Hlth Sci, Multictr Postgrad Program Biochem & Mol Biol PMBq, Salvador, BA, Brazil, [Rocha, Danilo J. P. G.] Univ Fed Bahia, Inst Hlth Sci, Postgrad Program Biotechnol, Salvador, BA, Brazil, [Pacheco, Luis G. C.] Univ Fed Bahia, Inst Hlth Sci, Postgrad Program Biotechnol, Salvador, BA, Brazil, [Ramos, Rommel T. J.] Fed Univ Para, Inst Biol Sci, Belem, Para, Brazil, [Silva, Artur] Fed Univ Para, Inst Biol Sci, Belem, Para, Brazil, [Brenig, Bertram] Univ Gottingen, Inst Vet Med, Gottingen, Germany, [Goes-Neto, Aristoteles] Univ Fed Minas Gerais, Inst Biol Sci, Belo Horizonte, MG, Brazil, [Azevedo, Vasco] Univ Fed Minas Gerais, Inst Biol Sci, Belo Horizonte, MG, Brazil, [Costa, Mateus M.] Univ Fed Vale Do Sao Francisco, Lab Microbiol & Imunol Anim LAMIA, Petrolina, PE, Brazil, [Soares, Siomar C.] Fed Univ Triangulo Mineiro UFTM, Inst Biol & Nat Sci, Dept Immunol Microbiol & Parasitol, Uberaba, MG, Brazil, [Aguiar, Eric R. G. R.] State Univ St Cruz, Dept Biol Sci, Ilheus, BA, Brazil, [Martinez-Martinez, Luiz] Hosp Univ Reina Sofia, Unidad Gest Clin, Cordoba, Spain, [Martinez-Martinez, Luiz] Univ Cordoba, Dept Microbiol, Cordoba, Spain, [Martinez-Martinez, Luiz] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Ocampo, Alain] Univ Hosp Marques de Valdecilla, Microbiol Serv, Santander, Spain, [Ocampo, Alain] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Dorta, Alexis] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Navas, Jesus] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Alibi, Sana] Res Unit Anal & Proc Appl Environm, Rejiche, Tunisia, [Dorta, Alexis] Cantabria Univ, Fac Med, BIOMEDAGE Grp, Santander, Spain, [Navas, Jesus] Cantabria Univ, Fac Med, BIOMEDAGE Grp, Santander, Spain, FAPESB, CNPq, CAPES, and RECOM Network, Brazil
Subjects: Islands, System, Microbiology (medical), Identification, Virulence, Iron, Diphtheriae, virulence factor, Microbiology, Pilus, Mycolic acids, multidrug resistance, Siderophore, Corynebacterium amycolatum, pan-genome, emerging pathogen, Cell-wall
Abstract: Corynebacterium amycolatum is a nonlipophilic coryneform which is increasingly being recognized as a relevant human and animal pathogen showing multidrug resistance to commonly used antibiotics. However, little is known about the molecular mechanisms involved in transition from colonization to the MDR invasive phenotype in clinical isolates. In this study, we performed a comprehensive pan-genomic analysis of C. amycolatum, including 26 isolates from different countries. We obtained the novel genome sequences of 8 of them, which are multidrug resistant clinical isolates from Spain and Tunisia. They were analyzed together with other 18 complete or draft C. amycolatum genomes retrieved from GenBank. The species C. amycolatum presented an open pan-genome (α = 0.854905), with 3,280 gene families, being 1,690 (51.52%) in the core genome, 1,121 related to accessory genes (34.17%), and 469 related to unique genes (14.29%). Although some classic corynebacterial virulence factors are absent in the species C. amycolatum, we did identify genes associated with immune evasion, toxin, and antiphagocytosis among the predicted putative virulence factors. Additionally, we found genomic evidence for extensive acquisition of antimicrobial resistance genes through genomic islands.
Published: 2022

4. [Translated article] Current State of Skin Cancer Prevention: A Systematic Review

Author: Alonso-Belmonte, C., Montero-Vilchez, T., Arias-Santiago, S., Buendia-Eisman, A., [Alonso-Belmonte, C.] Univ Granada, Fac Med, Granada, Spain, [Montero-Vilchez, T.] Univ Granada, Fac Med, Granada, Spain, [Arias-Santiago, S.] Univ Granada, Fac Med, Granada, Spain, [Buendia-Eisman, A.] Univ Granada, Fac Med, Granada, Spain, [Montero-Vilchez, T.] Hosp Univ Virgen Nieves, Serv Dermatol, Granada, Spain, and [Arias-Santiago, S.] Hosp Univ Virgen Nieves, Serv Dermatol, Granada, Spain
Subjects: Primary prevention, Secondary prevention, Follow-up, Risk prediction models, Sun protection, Protective behaviors, Malignant-melanoma, Visual images, Skin cancer, Basal-cell carcinoma, Mortality, Melanoma, Primary cutaneous melanoma, Interventions
Abstract: Skin cancer deaths continue to rise despite the implementation of numerous preventive campaigns and programs. The aim of this systematic review was to evaluate reviews of primary and secondary skin cancer prevention strategies as reported over the past 10 years. We analyzed 63 systematic reviews and meta-analyses: 30 (46.6%) addressing primary interventions and 35 (55.6%) addressing secondary interventions. Two of the reviews covered both. The most widely reported primary prevention approaches were education programs (63.3%), followed by risk modeling to identify individuals at high risk for melanoma (17.6%), and the promotion of sunscreen use (11.8%). The most widely reported secondary prevention measures concerned imaging systems for early skin cancer detection (40%), smartphones and new technologies (22.9%), and visual diagnosis in population-based screening (17.4%). The most effective measures were primary prevention education programs to improve sun protection habits. (C) 2022 AEDV. Published by Elsevier Espana, S.L.U.
Published: 2022

5. New imaging technologies for robotic kidney cancer surgery

Author: Puliatti, Stefano, Eissa, Ahmed, Checcucci, Enrico, Piazza, Pietro, Amato, Marco, Ferretti, Stefania, Scarcella, Simone, Rivas, Juan Gomez, Taratkin, Mark, Marenco, Jose, Rivero, Ines Belenchon, Kowalewski, Karl-Friedrich, Cacciamani, Giovanni, El-Sherbiny, Ahmed, Zoeir, Ahmed, El-Bahnasy, Abdelhamid M., De Groote, Ruben, Mottrie, Alexandre, Micali, Salvatore, [Puliatti, Stefano] Univ Modena & Reggio Emilia, Urol Dept, Modena, Italy, [Amato, Marco] Univ Modena & Reggio Emilia, Urol Dept, Modena, Italy, [Ferretti, Stefania] Univ Modena & Reggio Emilia, Urol Dept, Modena, Italy, [Micali, Salvatore] Univ Modena & Reggio Emilia, Urol Dept, Modena, Italy, [Puliatti, Stefano] ORSI Acad, Melle, Belgium, [De Groote, Ruben] ORSI Acad, Melle, Belgium, [Mottrie, Alexandre] ORSI Acad, Melle, Belgium, [Eissa, Ahmed] Tanta Univ, Fac Med, Urol Dept, Tanta, Egypt, [El-Sherbiny, Ahmed] Tanta Univ, Fac Med, Urol Dept, Tanta, Egypt, [Zoeir, Ahmed] Tanta Univ, Fac Med, Urol Dept, Tanta, Egypt, [El-Bahnasy, Abdelhamid M.] Tanta Univ, Fac Med, Urol Dept, Tanta, Egypt, [Checcucci, Enrico] FPO IRCCS, Dept Surg, Candiolo Canc Inst, Turin, Italy, [Piazza, Pietro] IRCCS Azienda Osped Univ Bologna, Div Urol, Bologna, Italy, [Scarcella, Simone] Polytech Univ Marche Reg, Umberto I Hosp Osped Riuniti, Dept Urol, Ancona, Italy, [Rivas, Juan Gomez] European Assoc Urol, Urotechnol & SoMe Working Grp Young Acad Urologis, Arnhem, Netherlands, [Taratkin, Mark] European Assoc Urol, Urotechnol & SoMe Working Grp Young Acad Urologis, Arnhem, Netherlands, [Marenco, Jose] European Assoc Urol, Urotechnol & SoMe Working Grp Young Acad Urologis, Arnhem, Netherlands, [Rivas, Juan Gomez] Hosp Clin San Carlos, Dept Urol, Madrid, Spain, [Taratkin, Mark] Sechenov Univ, Inst Urol & Reprod Hlth, Moscow, Russia, [Marenco, Jose] Fdn Inst Valenciano Oncol, Dept Urol, Valencia, Spain, [Rivero, Ines Belenchon] Virgen del Rocio Univ Hosp, Urol & Nephrol Dept, Seville, Spain, [Kowalewski, Karl-Friedrich] Univ Med Ctr Mannheim, Dept Urol & Urol Surg, Mannheim, Germany, [Cacciamani, Giovanni] Univ Southern Calif, USC Inst Urol, Los Angeles, CA 90007 USA, [De Groote, Ruben] Onze Lieve Vrouw Hosp, Dept Urol, Aalst, Belgium, and [Mottrie, Alexandre] Onze Lieve Vrouw Hosp, Dept Urol, Aalst, Belgium
Subjects: Physical models, Technology, Score, Kidney cancer, Renal tumors, Indocyanine green, Imaging, Robotic, Time, Assisted partial nephrectomy, Impact, Perioperative outcomes, Ischemia, Reconstruction
Abstract: Objective: Kidney cancers account for approximately 2% of all newly diagnosed cancer in 2020. Among the primary treatment options for kidney cancer, urologist may choose between radical or partial nephrectomy, or ablative therapies. Nowadays, robotic-assisted partial nephrectomy (RAPN) for the management of renal cancers has gained popularity, up to being considered the gold standard. However, RAPN is a challenging procedure with a steep learning curve.Methods: In this narrative review, different imaging technologies used to guide and aid RAPN are discussed.Results: Three-dimensional visualization technology has been extensively discussed in RAPN, showing its value in enhancing robotic-surgery training, patient counseling, surgical planning, and intraoperative guidance. Intraoperative imaging technologies such as intracorporeal ultrasound, near-infrared fluorescent imaging, and intraoperative pathological examination can also be used to improve the outcomes following RAPN. Finally, artificial intelligence may play a role in the field of RAPN soon.Conclusion: RAPN is a complex surgery; however, many imaging technologies may play an important role in facilitating it. (C) 2022 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Published: 2022

6. Optical Behavior of Human Skin Substitutes: Absorbance in the 200-400 nm UV Range

Author: Javier Ruiz-López, Juan C. Cardona, Ingrid Garzón, María M. Pérez, Miguel Alaminos, Jesus Chato-Astrain, Ana M. Ionescu, [Ruiz-Lopez, Javier] Univ Granada, Fac Sci, Dept Opt, Lab Biomat Opt, E-18071 Granada, Spain, [Cardona, Juan C.] Univ Granada, Fac Sci, Dept Opt, Lab Biomat Opt, E-18071 Granada, Spain, [Perez, Maria M.] Univ Granada, Fac Sci, Dept Opt, Lab Biomat Opt, E-18071 Granada, Spain, [Ionescu, Ana M.] Univ Granada, Fac Sci, Dept Opt, Lab Biomat Opt, E-18071 Granada, Spain, [Ruiz-Lopez, Javier] Inst Invest Biosanitaria IbsGRANADA, E-18011 Granada, Spain, [Cardona, Juan C.] Inst Invest Biosanitaria IbsGRANADA, E-18011 Granada, Spain, [Garzon, Ingrid] Inst Invest Biosanitaria IbsGRANADA, E-18011 Granada, Spain, [Perez, Maria M.] Inst Invest Biosanitaria IbsGRANADA, E-18011 Granada, Spain, [Alaminos, Miguel] Inst Invest Biosanitaria IbsGRANADA, E-18011 Granada, Spain, [Chato-Astrain, Jesus] Inst Invest Biosanitaria IbsGRANADA, E-18011 Granada, Spain, [Ionescu, Ana M.] Inst Invest Biosanitaria IbsGRANADA, E-18011 Granada, Spain, [Garzon, Ingrid] Univ Granada, Fac Med, Dept Histol, Tissue Engn Grp, E-18016 Granada, Spain, [Alaminos, Miguel] Univ Granada, Fac Med, Dept Histol, Tissue Engn Grp, E-18016 Granada, Spain, [Chato-Astrain, Jesus] Univ Granada, Fac Med, Dept Histol, Tissue Engn Grp, E-18016 Granada, Spain, Consejeria de Salud y Familias, Junta de Andalucia, Spain, University of Granada, Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, European Regional Development Fund (ERDF) through the 'Una manera de hacer Europa' program, Junta de Andalucia, and Spanish Ministry of Science, Innovation and Universities
Subjects: Biomaterials, Protein, bioengineered skin, Medicine (miscellaneous), Ultraviolet-radiation, fibrin-agarose biomaterial, absorption, UV radiation, General Biochemistry, Genetics and Molecular Biology, Stem-cells, Photobiology
Abstract: The most recent generation of bioengineered human skin allows for the efficient treatment of patients with severe skin defects. Despite UV sunlight can seriously affect human skin, the optical behavior in the UV range of skin models is still unexplored. In the present study, absorbance and transmittance of the UGRSKIN bioartificial skin substitute generated with human skin cells combined with fibrin-agarose biomaterials were evaluated for: UV-C (200–280 nm), -B (280–315 nm), and -A (315–400 nm) spectral range after 7, 14, 21 and 28 days of ex vivo development. The epidermis of the bioartificial skin substitute was able to mature and differentiate in a time-dependent manner, expressing relevant molecules able to absorb most of the incoming UV radiation. Absorbance spectral behavior of the skin substitutes showed similar patterns to control native skin (VAF > 99.4%), with values 0.85–0.90 times lower than control values at 7 and 14- days and 1.05–1.10 times the control values at 21- and 28-days. UV absorbance increased, and UV transmission decreased with culture time, and comparable results to the control were found at 21 and 28 days. These findings support the use of samples corresponding to 21 or 28 days of development for clinical purposes due to their higher histological similarities with native skin, but also because of their absorbance of UV radiation., Junta de Andalucia PE-0395-2019, University of Granada B-CTS-450-UGR20 A.TEP.280.UGR18, Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades B-CTS-450-UGR20, European Regional Development Fund (ERDF) through the "Una manera de hacer Europa" program Junta de Andalucia P20-00200, Spanish Government PGC2018-101904-A-100
Published: 2022

7. Diagnostic accuracy of the waist-to-height ratio and other anthropometric indices for metabolically healthy obesity in the working population

Author: Guzman-Garcia, Jose-Miguel, Romero-Saldana, Manuel, Molina-Recio, Guillermo, Alvarez-Fernandez, Carlos, Raya-Cano, Elena, Molina-Luque, Rafael, [Guzman-Garcia, Jose-Miguel] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba, Spain, [Romero-Saldana, Manuel] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba, Spain, [Molina-Recio, Guillermo] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba, Spain, [Raya-Cano, Elena] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba, Spain, [Molina-Luque, Rafael] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba, Spain, [Romero-Saldana, Manuel] Maimonides Biomed Res Inst Cordoba IMIBIC, Lifestyles Innovat & Hlth Res Associate Grp, Cordoba, Spain, [Molina-Recio, Guillermo] Maimonides Biomed Res Inst Cordoba IMIBIC, Lifestyles Innovat & Hlth Res Associate Grp, Cordoba, Spain, [Molina-Luque, Rafael] Maimonides Biomed Res Inst Cordoba IMIBIC, Lifestyles Innovat & Hlth Res Associate Grp, Cordoba, Spain, and [Alvarez-Fernandez, Carlos] Cordoba City Council, Dept Occupat Hlth & Safety, Cordoba, Spain
Subjects: obesity, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, working population, Prevalence, metabolically healthy obesity, anthropometric indices, abdominal obesity, Food Science
Abstract: Approximately one-third of overweight individuals, and half of those with obesity, do not have cardiometabolic disorders. For this reason, a phenotype called metabolically healthy obese (MHO) has emerged to describe this population group. The early detection of this situation could save costs associated with the development of comorbidities or pharmacological interventions. Therefore, the aim is to know the prevalence of MHO in the working population and propose variables for its detection. Cross-sectional descriptive study of 635 workers of the Cordoba City Council was carried out based on the results of the 2016 health surveillance. The outcome variables were the MHO, established based on the criteria of the IDF, NCEP—ATP III, and Aguilar—Salinas. In addition, the degree of agreement between the different MHO criteria was studied using Cohen's kappa (k), and the predictive capacity of the anthropometric variables was assessed with Receiver Operator Curves. The prevalence of MHO ranged from 6.6 to 9%. The highest agreement was reached between the IDF and NCEP-ATP III definitions (k = 0.811; 95% CI 0.724–0.898; p < 0.001). The waist-to-height ratio (WHtR) showed the highest discriminant capacity for MHO, with its best cut-off point at 0.55 for all criteria used. Sensitivity ranged from 84 to 93%. The prevalence of MHO in the working population differed according to the criteria used for diagnosis. The anthropometric variable with the highest discriminant capacity for MHO was WHtR, presenting the same cut-off point in the three criteria analyzed. Therefore, WHtR is the variable that best detects the presence of MHO.
Published: 2022

8. Brain charts for the human lifespan

Author: Armin Raznahan, Eric Courchesne, Andrea Parolin Jackowski, Kamen A. Tsvetanov, Cameron T. Ellis, R.C. Gur, Bin Bae J, Park Mtm, Pedro A. Valdes-Sosa, Simon N. Vandekar, Jacob W. Vogel, Juan Zhou, Machteld Marcelis, Kiho Im, Patricia Ellen Grant, Minhui Ouyang, Blesa Cabez M, Michael V. Lombardo, Sarah E. Morgan, James P. Boardman, Adamson C, Calhoun Vd, Delarue M, James H. Cole, Pichet Binette A, Roberto Toro, David H. Rowitch, Nynke A. Groenewold, Kevin M. Anderson, David T.W. Jones, Michael Schöll, Wang Ys, Aiden Corvin, R.E. Gur, Damien A. Fair, Gareth Ball, Herma Lina Schaare, Andrew Zalesky, Evdokia Anagnostou, Michael J. Meaney, Taki Y, Gareth J. Sullivan, Warrier, Petra E. Vértes, Chixiang Chen, Lisa T. Eyler, Wei Liao, Tomáš Paus, Jeremy A. Elman, Phillip McGuire, Hisham Ziauddeen, William S. Kremen, Etienne Vachon-Presseau, E.T. Bullmore, Christophe Tzourio, White, Hammill Cf, Mothersill D, Richard N. Henson, Jiang Qiu, Duncan E. Astle, Fabrice Crivello, Paul C. Fletcher, Chertavian C, Kim K, Jennifer Crosbie, Russell Schachar, Gabriel A. Devenyi, Manfred G. Kitzbichler, Tianye Jia, Trey Hedden, Sang Jae Lee, Ross D. Markello, Silke Kern, Ian M. Goodyer, Keith A. Johnson, Frauke Beyer, Bernard Mazoyer, A. Heinz, Sylvane Desrivières, Rosenberg, Gary Donohoe, Ong Mq, Alexander D. Edwards, Dan J. Stein, Nenad Medic, Zuo Xn, Travis T. Mallard, Peter Fonagy, Lindsay W. Victoria, Ingmar Skoog, Avram J. Holmes, Jason P. Lerch, Jed T. Elison, Jianfu Li, John H. Gilmore, Rosemary Holt, Caitlin K. Rollins, Carol E. Franz, Pedro Mario Pan, Saashi A Bedford, Yang N, Jonathan C Ipser, Richard A. I. Bethlehem, Tuulari Jj, Stolicyn A, Hua Huang, Bratislav Misic, Conor Liston, Ayub M, Lisa Ronan, Yeo Bt, Sophie Adler, Charles J. Lynch, Faith M. Gunning, Konrad Wagstyl, M. Mallar Chakravarty, John Suckling, Theodore D. Satterthwaite, Bharath Holla, Yap Seng Chong, Jinglei Lv, Jakob Seidlitz, Niall J Bourke, Xinlei Qian, Simon Baron-Cohen, Cynthia M. Ortinau, Deirel Paz Linares, Thyreau B, René S. Kahn, Aaron P. Schultz, Vanessa Cropley, Eric Westman, Mitchell Valdés-Sosa, Rik Ossenkoppele, André Zugman, Hasse Karlsson, Sylvia Villeneuve, Katja Heuer, Di Biase Ma, Margaret L. Westwater, Sofie L. Valk, David J. Sharp, Brigitte Landeau, Matthew Borzage, Kirsten A. Donald, Timothy Rittman, Richard Beare, Giovanni Abrahão Salum, Gunter Schumann, Ryuta Kawashima, Romero-Garcia R, John Blangero, Yun Hj, Russel T. Shinohara, Nicolas Crossley, Simon K. Warfield, Karen Pierce, George S. Alexopoulos, Katharine Dunlop, David C. Glahn, Francois Lalonde, Anqi Qiu, Lana Vasung, Gaël Chételat, Lídice Galán-García, Clifford R. Jack, Reisa A. Sperling, Anna Zettergren, Elizabeth Kelley, Arno Villringer, Andrea Mechelli, Benegal, Aaron Alexander-Bloch, Nicholas B. Turk-Browne, van Amelsvoort T, John D. Lewis, Heather C. Whalley, A. V. Witte, Zdenka Pausova, Joel T. Nigg, Heather J. Zar, Raymond J. Dolan, Christopher D. Smyser, Jay N. Giedd, Lena Palaniyappan, Ali Gholipour, Areces-Gonzalez A, Peter B. Jones, Jacqueline Hoare, Oskar Hansson, Linnea Karlsson, C Pantelis, Paly L, Bonnie Auyeung, Jorge Bosch-Bayard, Bethlehem, Richard [0000-0002-0714-0685], White, Simon [0000-0001-8642-7037], Astle, Duncan [0000-0002-7042-5392], Baron-Cohen, Simon [0000-0001-9217-2544], Henson, Rik [0000-0002-0712-2639], Jones, Peter [0000-0002-0387-880X], Kitzbichler, Manfred [0000-0002-4494-0753], Rittman, Timothy [0000-0003-1063-6937], Rowitch, David [0000-0002-0079-0060], Tsvetanov, Kamen A. [0000-0002-3178-6363], Westwater-Wozniak, Margaret [0000-0002-2918-0979], Ziauddeen, Hisham [0000-0003-4044-1719], Apollo - University of Cambridge Repository, British Academy, Autism Research Trust, National Institute of Mental Health (US), UK Research and Innovation, Medical Research Council (UK), National Institute for Health and Care Research (US), Wellcome Trust, University of Cambridge, Cambridge Biomedical Research Centre, University of Cambridge [UK] (CAM), University of Pennsylvania, Yale University [New Haven], Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Child and Adolescent Psychiatry Department [AP- HP Hôpital Robert Debré], AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de Neuroscience - Department of Neuroscience, Centre de Recherche Interdisciplinaire / Center for Research and Interdisciplinarity [Paris, France] (CRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Med Staf Spec Psychiatrie (9), Neurology, Amsterdam Neuroscience - Neurodegeneration, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM Team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA, [Bethlehem, R. A. I.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England, [Auyeung, B.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England, [Baron-Cohen, S.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England, [Bedford, S. A.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England, [Holt, R.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England, [Lombardo, M. V.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England, [Bethlehem, R. A. I.] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge, England, [Kitzbichler, M. G.] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge, England, [Seidlitz, J.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA, [Vogel, J. W.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA, [Gur, R. E.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA, [Gur, R. C.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA, [Jackowski, A. P.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA, [Satterthwaite, T. D.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA, [Alexander-Bloch, A. F.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA, [Seidlitz, J.] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, Philadelphia, PA 19104 USA, [Alexander-Bloch, A. F.] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, Philadelphia, PA 19104 USA, [Seidlitz, J.] Childrens Hosp Philadelphia & Penn Med, Lifespan Brain Inst, Philadelphia, PA USA, [Chertavian, C.] Childrens Hosp Philadelphia & Penn Med, Lifespan Brain Inst, Philadelphia, PA USA, [Gur, R. E.] Childrens Hosp Philadelphia & Penn Med, Lifespan Brain Inst, Philadelphia, PA USA, [Gur, R. C.] Childrens Hosp Philadelphia & Penn Med, Lifespan Brain Inst, Philadelphia, PA USA, [Alexander-Bloch, A. F.] Childrens Hosp Philadelphia & Penn Med, Lifespan Brain Inst, Philadelphia, PA USA, [White, S. R.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Goodyer, I. M.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Henson, R. N.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Jones, P. B.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Kitzbichler, M. G.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Medic, N.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Morgan, S. E.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Romero-Garcia, R.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Ronan, L.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Suckling, J.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Vertes, P. E.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Warrier, V.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Westwater, M. L.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Ziauddeen, H.] Univ Cambridge, Dept Psychiat, Cambridge, England, [Bullmore, E. T.] Univ Cambridge, Dept Psychiat, Cambridge, England, [White, S. R.] Univ Cambridge, MRC Biostat Unit, Cambridge, England, [Vogel, J. W.] Univ Penn, Lifespan Informat & Neuroimaging Ctr, Philadelphia, PA 19104 USA, [Satterthwaite, T. D.] Univ Penn, Lifespan Informat & Neuroimaging Ctr, Philadelphia, PA 19104 USA, [Anderson, K. M.] Yale Univ, Dept Psychol, New Haven, CT USA, [Ellis, C. T.] Yale Univ, Dept Psychol, New Haven, CT USA, [Turk-Browne, N. B.] Yale Univ, Dept Psychol, New Haven, CT USA, [Adamson, C.] Murdoch Childrens Res Inst, Dev Imaging, Melbourne, Vic, Australia, [Ball, G.] Murdoch Childrens Res Inst, Dev Imaging, Melbourne, Vic, Australia, [Beare, R.] Murdoch Childrens Res Inst, Dev Imaging, Melbourne, Vic, Australia, [Jackowski, A. P.] Murdoch Childrens Res Inst, Dev Imaging, Melbourne, Vic, Australia, [Adamson, C.] Monash Univ, Dept Med, Melbourne, Vic, Australia, [Beare, R.] Monash Univ, Dept Med, Melbourne, Vic, Australia, [Adler, S.] UCL Great Ormond St Inst Child Hlth, London, England, [Alexopoulos, G. S.] Weill Cornell Med, Dept Psychiat, Weill Cornell Inst Geriatr Psychiat, New York, NY USA, [Anagnostou, E.] Univ Toronto, Dept Pediat, Toronto, ON, Canada, [Anagnostou, E.] Holland Bloorview Kids Rehabil Hosp, Toronto, ON, Canada, [Pierce, K.] Holland Bloorview Kids Rehabil Hosp, Toronto, ON, Canada, [Areces-Gonzalez, A.] Univ Elect Sci & Technol China, MOE Key Lab NeuroInformat, Clin Hosp, Chengdu Brain Sci Inst, Chengdu, Peoples R China, [Paz-Linares, D.] Univ Elect Sci & Technol China, MOE Key Lab NeuroInformat, Clin Hosp, Chengdu Brain Sci Inst, Chengdu, Peoples R China, [Areces-Gonzalez, A.] Univ Pinar del Rio Hermanos Saiz Montes de Oca, Pinar Del Rio, Cuba, [Astle, D. E.] Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England, [Henson, R. N.] Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England, [Whalley, H. C.] Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England, [Auyeung, B.] Univ Edinburgh, Sch Philosophy Psychol & Language Sci, Dept Psychol, Edinburgh, Midlothian, Scotland, [Pausova, Z.] Univ Edinburgh, Sch Philosophy Psychol & Language Sci, Dept Psychol, Edinburgh, Midlothian, Scotland, [Ayub, M.] Queens Univ, Dept Psychiat, Ctr Neurosci Studies, Kingston, ON, Canada, [Ayub, M.] UCL, Mental Hlth Neurosci Res Dept, Div Psychiat, London, England, [Bae, J.] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Seongnam, South Korea, [Ball, G.] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia, [Baron-Cohen, S.] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge Lifetime Asperger Syndrome Serv CLASS, Cambridge, England, [Benegal, V.] Natl Inst Mental Hlth & Neurosci NIMHANS, Ctr Addict Med, Bengaluru, India, [Beyer, F.] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Leipzig, Germany, [Villringer, A.] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Leipzig, Germany, [Witte, A. V.] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Leipzig, Germany, [Blangero, J.] Univ Texas Rio Grande Valley, South Texas Diabet & Obes Inst, Dept Human Genet, Edinburg, TX USA, [Blesa Cabez, M.] Univ Edinburgh, MRC Ctr Reprod Hlth, Edinburgh, Midlothian, Scotland, [Boardman, J. P.] Univ Edinburgh, MRC Ctr Reprod Hlth, Edinburgh, Midlothian, Scotland, [Sullivan, G.] Univ Edinburgh, MRC Ctr Reprod Hlth, Edinburgh, Midlothian, Scotland, [Borzage, M.] Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Fetal & Neonatal Inst,Div Neonatol,Dept Pediat, Los Angeles, CA 90007 USA, [Bosch-Bayard, J. F.] Montreal Neurol Inst, Ludmer Ctr Neuroinformat & Mental Hlth, McGill Ctr Integrat Neurosci, Montreal, PQ, Canada, [Bosch-Bayard, J. F.] McGill Univ, Montreal, PQ, Canada, [Chakravarty, M. M.] McGill Univ, Montreal, PQ, Canada, [Bourke, N.] Imperial Coll London, Dept Brain Sci, London, England, [Sharp, D.] Imperial Coll London, Dept Brain Sci, London, England, [Alexander-Bloch, A. F.] Imperial Coll London, Dept Brain Sci, London, England, [Bourke, N.] Dementia Res Inst, Care Res & Technol Ctr, London, England, [Calhoun, V. D.] Georgia State Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Georgia Inst Technol, Atlanta, GA 30303 USA, [Calhoun, V. D.] Emory Univ, Atlanta, GA 30322 USA, [Chakravarty, M. M.] Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Comp Brain Anat CoBrA Lab, Montreal, PQ, Canada, [Chen, C.] Univ Penn, Penn Stat Imaging & Visualizat Ctr, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA 19104 USA, [Shinohara, R. T.] Univ Penn, Penn Stat Imaging & Visualizat Ctr, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA 19104 USA, [Chetelat, G.] Normandie Univ, PhIND Physiopathol & Imaging Neurol Disorders, Inst Blood & Brain Caen Normandie, UNICAEN,INSERM,U1237, Caen, France, [Delarue, M.] Normandie Univ, PhIND Physiopathol & Imaging Neurol Disorders, Inst Blood & Brain Caen Normandie, UNICAEN,INSERM,U1237, Caen, France, [Landeau, B.] Normandie Univ, PhIND Physiopathol & Imaging Neurol Disorders, Inst Blood & Brain Caen Normandie, UNICAEN,INSERM,U1237, Caen, France, [Paly, L.] Normandie Univ, PhIND Physiopathol & Imaging Neurol Disorders, Inst Blood & Brain Caen Normandie, UNICAEN,INSERM,U1237, Caen, France, [Chong, Y. S.] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore, [Chong, Y. S.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore, [Cole, J. H.] UCL, Ctr Med Image Comp CMIC, London, England, [Cole, J. H.] UCL, Dementia Res Ctr DRC, London, England, [Corvin, A.] Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland, [Costantino, M.] Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Verdun, PQ, Canada, [Costantino, M.] McGill Univ, Undergrad Program Neurosci, Montreal, PQ, Canada, [Courchesne, E.] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA, [Courchesne, E.] Univ Calif San Diego, Autism Ctr Excellence, San Diego, CA 92103 USA, [Crivello, F.] Univ Bordeaux, Inst Neurodegenerat Disorders, CNRS UMR5293, CEA, Bordeaux, France, [Mazoyer, B.] Univ Bordeaux, Inst Neurodegenerat Disorders, CNRS UMR5293, CEA, Bordeaux, France, [Cropley, V. L.] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia, [Di Biase, M. A.] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia, [Lv, J.] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia, [Zalesky, A.] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia, [Hammill, C. F.] Hosp Sick Children, Toronto, ON, Canada, [Schachar, R. J.] Hosp Sick Children, Toronto, ON, Canada, [Crossley, N.] Pontificia Univ Catolica Chile, Sch Med, Dept Psychiat, Santiago, Chile, [Crossley, N.] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England, [McGuire, P.] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England, [Crossley, N.] Inst Milenio Intelligent Healthcare Engn, Santiago, Chile, [Delorme, R.] Robert Debre Univ Hosp, AP HP, Child & Adolescent Psychiat Dept, Paris, France, [Delorme, R.] Inst Pasteur, Human Genet & Cognit Funct, Paris, France, [Desrivieres, S.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England, [Devenyi, G. A.] Douglas Mental Hlth Univ Inst, McGill Dept Psychiat, Cerebral Imaging Ctr, Montreal, PQ, Canada, [Devenyi, G. A.] McGill Univ, Dept Psychiat, Montreal, PQ, Canada, [Di Biase, M. A.] Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA, [Dolan, R.] UCL, Max Planck UCL Ctr Computat Psychiat & Ageing Res, London, England, [Dolan, R.] Wellcome Ctr Human Neuroimaging, London, England, [Wagstyl, K.] Wellcome Ctr Human Neuroimaging, London, England, [Donald, K. A.] Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, Div Dev Paediat, Cape Town, South Africa, [Donald, K. A.] Univ Cape Town, Neurosci Inst, Cape Town, South Africa, [Groenewold, N. A.] Univ Cape Town, Neurosci Inst, Cape Town, South Africa, [Donohoe, G.] Natl Univ Ireland Galway, Sch Psychol, Ctr Neuroimaging Cognit & Genom NICOG, Galway, Ireland, [Dunlop, K.] Weill Cornell Med, Dept Psychiat, Weil Family Brain & Mind Res Inst, New York, NY USA, [Lynch, C.] Weill Cornell Med, Dept Psychiat, Weil Family Brain & Mind Res Inst, New York, NY USA, [Edwards, A. D.] Kings Coll London, Ctr Dev Brain, London, England, [Edwards, A. D.] Evelina London Childrens Hosp, London, England, [Edwards, A. D.] MRC Ctr Neurodev Disorders, London, England, [Elison, J. T.] Univ Minnesota, Mason Inst Dev Brain, Dept Pediat, Inst Child Dev, Minneapolis, MN USA, [Fair, D. A.] Univ Minnesota, Mason Inst Dev Brain, Dept Pediat, Inst Child Dev, Minneapolis, MN USA, [Feczko, E.] Univ Minnesota, Mason Inst Dev Brain, Dept Pediat, Inst Child Dev, Minneapolis, MN USA, [Ellis, C. T.] Haskins Labs Inc, New Haven, CT USA, [Elman, J. A.] Univ Calif San Diego, Dept Psychiat, Ctr Behav Genet Aging, La Jolla, CA 92093 USA, [Franz, C. E.] Univ Calif San Diego, Dept Psychiat, Ctr Behav Genet Aging, La Jolla, CA 92093 USA, [Kremen, W. S.] Univ Calif San Diego, Dept Psychiat, Ctr Behav Genet Aging, La Jolla, CA 92093 USA, [Eyler, L.] VA San Diego Healthcare, Desert Pacific Mental Illness Res Educ & Clin Ctr, San Diego, CA USA, [Eyler, L.] Univ Calif San Diego, Dept Psychiat, Los Angeles, CA USA, [Fletcher, P. C.] Univ Cambridge, Dept Psychiat, Cambridge Biomed Campus, Cambridge, England, [Fletcher, P. C.] Wellcome Trust MRC Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England, [Fletcher, P. C.] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England, [Jones, P. B.] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England, [Suckling, J.] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England, [Ziauddeen, H.] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England, [Fonagy, P.] UCL, Dept Clin Educ & Hlth Psychol, London, England, [Fonagy, P.] Anna Freud Natl Ctr Children & Families, London, England, [Galan-Garcia, L.] Cuban Ctr Neurosci, Havana, Cuba, [Valdes-Sosa, M. J.] Cuban Ctr Neurosci, Havana, Cuba, [Gholipour, A.] Boston Childrens Hosp, Computat Radiol Lab, Boston, MA USA, [Warfield, S. K.] Boston Childrens Hosp, Computat Radiol Lab, Boston, MA USA, [Giedd, J.] Univ Calif San Diego, Dept Child & Adolescent Psychiat, San Diego, CA 92103 USA, [Giedd, J.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA, [Gilmore, J. H.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA, [Glahn, D. C.] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA, [Im, K.] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA, [Mathias, S. R.] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA, [Rodrigue, A.] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA, [Glahn, D. C.] Harvard Med Sch, Boston, MA 02115 USA, [Im, K.] Harvard Med Sch, Boston, MA 02115 USA, [Johnson, K. A.] Harvard Med Sch, Boston, MA 02115 USA, [Mathias, S. R.] Harvard Med Sch, Boston, MA 02115 USA, [Rodrigue, A.] Harvard Med Sch, Boston, MA 02115 USA, [Schultz, A. P.] Harvard Med Sch, Boston, MA 02115 USA, [Sperling, R. A.] Harvard Med Sch, Boston, MA 02115 USA, [Grant, P. E.] Harvard Med Sch, Fetal Neonatal Neuroimaging & Dev Sci Ctr, Boston Childrens Hosp, Div Newborn Med & Neuroradiol, Boston, MA 02115 USA, [Groenewold, N. A.] Univ Cape Town, SA MRC Unit Child & Adolescent Hlth, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, Cape Town, South Africa, [Zar, H. J.] Univ Cape Town, SA MRC Unit Child & Adolescent Hlth, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, Cape Town, South Africa, [Gunning, F. M.] Weill Cornell Med, Dept Psychiat, Weill Cornell Inst Geriatr Psychiat, New York, NY USA, [Victoria, L. W.] Weill Cornell Med, Dept Psychiat, Weill Cornell Inst Geriatr Psychiat, New York, NY USA, [Hammill, C. F.] Mouse Imaging Ctr, Toronto, ON, Canada, [Hansson, O.] Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden, [Hansson, O.] Skane Univ Hosp, Memory Clin, Malmo, Sweden, [Hedden, T.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA, [Hedden, T.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula Martinos Ctr Biomed Imaging, Boston, MA 02115 USA, [Heinz, A.] Charite Univ Med Berlin, Charite Campus Mitte, Berlin, Germany, [Heinz, A.] Free Univ Berlin, Charite Campus Mitte, Berlin, Germany, [Heinz, A.] Humboldt Univ, Dept Psychiat & Psychotherapy, Charite Campus Mitte, Berlin, Germany, [Heuer, K.] Max Planck Inst Human Cognit & Brain Sci, Dept Neuropsychol, Leipzig, Germany, [Heuer, K.] Univ Paris, Paris, France, [Toro, R.] Univ Paris, Paris, France, [Hoare, J.] Univ Cape Town, Dept Psychiat, Cape Town, South Africa, [Holla, B.] NIMHANS, Dept Integrat Med, Bengaluru, India, [Holla, B.] NIMHANS, Dept Psychiat, Accelerator Program Discovery Brain Disorders Usi, Bengaluru, India, [Holmes, A. J.] Yale Univ, Dept Psychol, New Haven, CT USA, [Villeneuve, S.] Yale Univ, Dept Psychol, New Haven, CT USA, [Holmes, A. J.] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA, [Villeneuve, S.] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA, [Huang, H.] Childrens Hosp Philadelphia, Radiol Res, Philadelphia, PA 19104 USA, [Ouyang, M.] Childrens Hosp Philadelphia, Radiol Res, Philadelphia, PA 19104 USA, [Huang, H.] Univ Penn, Dept Radiol, Perelman Sch Med, Philadelphia, PA 19104 USA, [Ipser, J.] Univ Cape Town, Dept Psychiat & Mental Hlth, Clin Neurosci Inst, Cape Town, South Africa, [Jack, C. R., Jr.] Mayo Clin, Dept Radiol, Rochester, MN USA, [Jones, D. T.] Mayo Clin, Dept Radiol, Rochester, MN USA, Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil, [Jackowski, A. P.] Natl Inst Dev Psychiat, Beijing, Peoples R China, [Jia, T.] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China, [Jia, T.] Fudan Univ, Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai, Peoples R China, [Jia, T.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Precis Med PONS, SGDP Ctr, London, England, [Johnson, K. A.] Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA, [Schultz, A. P.] Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA, [Sperling, R. A.] Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA, [Johnson, K. A.] Brigham & Womens Hosp, Dept Neurol, Ctr Alzheimer Res & Treatment, 75 Francis St, Boston, MA 02115 USA, [Sperling, R. A.] Brigham & Womens Hosp, Dept Neurol, Ctr Alzheimer Res & Treatment, 75 Francis St, Boston, MA 02115 USA, [Johnson, K. A.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA, [Jones, D. T.] Mayo Clin, Dept Neurol, Rochester, MN USA, [3R-BRAIN] Mayo Clin, Dept Neurol, Rochester, MN USA, [Kahn, R. S.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA, [Karlsson, H.] Univ Turku, Dept Psychiat, Dept Clin Med, Turku, Finland, [Karlsson, L.] Univ Turku, Dept Psychiat, Dept Clin Med, Turku, Finland, [Tuulari, J. J.] Univ Turku, Dept Psychiat, Dept Clin Med, Turku, Finland, [Karlsson, H.] Univ Turku, FinnBrain Birth Cohort Study, Turku Brain & Mind Ctr, Turku, Finland, [Karlsson, L.] Univ Turku, FinnBrain Birth Cohort Study, Turku Brain & Mind Ctr, Turku, Finland, [Tuulari, J. J.] Univ Turku, FinnBrain Birth Cohort Study, Turku Brain & Mind Ctr, Turku, Finland, [Karlsson, H.] Turku Univ Hosp, Turku, Finland, [Karlsson, L.] Turku Univ Hosp, Turku, Finland, [Tuulari, J. J.] Turku Univ Hosp, Turku, Finland, [Karlsson, H.] Turku Univ Hosp, Ctr Populat Hlth Res, Turku, Finland, [Karlsson, L.] Turku Univ Hosp, Ctr Populat Hlth Res, Turku, Finland, [Karlsson, H.] Univ Turku, Turku, Finland, [Karlsson, L.] Univ Turku, Turku, Finland, [Kawashima, R.] Tohoku Univ, Inst Dev Aging & Canc, Aoba Ku, Sendai, Miyagi, Japan, [Taki, Y.] Tohoku Univ, Inst Dev Aging & Canc, Aoba Ku, Sendai, Miyagi, Japan, [Thyreau, B.] Tohoku Univ, Inst Dev Aging & Canc, Aoba Ku, Sendai, Miyagi, Japan, [Kelley, E. A.] Queens Univ, Ctr Neurosci Studies, Dept Psychol, Kingston, ON, Canada, [Kelley, E. A.] Queens Univ, Ctr Neurosci Studies, Dept Psychiat, Kingston, ON, Canada, [Kern, S.] Univ Gothenburg, Neuropsychiat Epidemiol Unit, Dept Psychiat & Neurochem,Sahlgrenska Acad, Ctr Ageing & Hlth AGECAP,Inst Neurosci & Physiol, Gothenburg, Sweden, [Skoog, I.] Univ Gothenburg, Neuropsychiat Epidemiol Unit, Dept Psychiat & Neurochem,Sahlgrenska Acad, Ctr Ageing & Hlth AGECAP,Inst Neurosci & Physiol, Gothenburg, Sweden, [Zettergren, A.] Univ Gothenburg, Neuropsychiat Epidemiol Unit, Dept Psychiat & Neurochem,Sahlgrenska Acad, Ctr Ageing & Hlth AGECAP,Inst Neurosci & Physiol, Gothenburg, Sweden, [Kern, S.] Sahlgrens Univ Hosp, Psychiat Cognit & Old Age Psychiat Clin, Reg Vastra Gotaland, Gothenburg, Sweden, [Skoog, I.] Sahlgrens Univ Hosp, Psychiat Cognit & Old Age Psychiat Clin, Reg Vastra Gotaland, Gothenburg, Sweden, [Kim, K. W.] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul, South Korea, [Kim, K. W.] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Seongnam, South Korea, [Kim, K. W.] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea, [Kim, K. W.] SNU MRC, Inst Human Behav Med, Seoul, South Korea, [Lalonde, F.] NIMH, Sect Dev Neurogenom, Human Genet Branch, Bethesda, MD 20892 USA, [Raznahan, A.] NIMH, Sect Dev Neurogenom, Human Genet Branch, Bethesda, MD 20892 USA, [Lee, S.] Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul, South Korea, [Lerch, J.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada, [Lerch, J.] Univ Oxford, Nuffield Dept Clin Neurosci, FMRIB, Wellcome Ctr Integrat Neuroimaging, Oxford, England, [Lewis, J. D.] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada, [Li, J.] Univ Elect Sci & Technol China, Clin Hosp, Chengdu Brain Sci Inst, Chengdu, Peoples R China, [Liao, W.] Univ Elect Sci & Technol China, Clin Hosp, Chengdu Brain Sci Inst, Chengdu, Peoples R China, [Valdes-Sosa, P. A.] Univ Elect Sci & Technol China, Clin Hosp, Chengdu Brain Sci Inst, Chengdu, Peoples R China, [Liston, C.] Weill Cornell Med, Dept Psychiat, New York, NY USA, [Liston, C.] Weill Cornell Med, Brain & Mind Res Inst, New York, NY USA, [Lombardo, M. V.] Ist Italiano Tecnol, Ctr Neurosci & Cognit Syst UniTn, Lab Autism & Neurodev Disorders, Rovereto, Italy, [Lv, J.] Univ Sydney, Sch Biomed Engn, Sydney, NSW, Australia, [Lv, J.] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia, [Mallard, T. T.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA, [Marcelis, M.] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, EURON,Med Ctr, Maastricht, Netherlands, [Marcelis, M.] Inst Mental Hlth Care Eindhoven GGzE, Eindhoven, Netherlands, [Markello, R. D.] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada, [Misic, B.] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada, [Vasung, L.] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada, [Mazoyer, B.] Douglas Mental Hlth Univ Inst, Ludmer Ctr Neuroinformat & Mental Hlth, Montreal, PQ, Canada, [Meaney, M. J.] Douglas Mental Hlth Univ Inst, Ludmer Ctr Neuroinformat & Mental Hlth, Montreal, PQ, Canada, [Meaney, M. J.] Singapore Inst Clin Sci, Singapore, Singapore, [Mechelli, A.] Bordeaux Univ Hosp, Bordeaux, France, [Morgan, S. E.] Univ Cambridge, Dept Comp Sci & Technol, Cambridge, England, [Morgan, S. E.] Alan Turing Inst, London, England, [Vertes, P. E.] Alan Turing Inst, London, England, [Mothersill, D.] Natl Coll Ireland, Sch Business, Dept Psychol, Dublin, Ireland, [Mothersill, D.] Natl Univ Ireland Galway, Sch Psychol, Galway, Ireland, [Mothersill, D.] Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom, Galway, Ireland, [Mothersill, D.] Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland, [Nigg, J.] Oregon Hlth & Sci Univ, Dept Psychiat, Sch Med, Portland, OR 97201 USA, [Ong, M. Q. W.] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Sleep & Cognit, Singapore, Singapore, [Qian, X.] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Sleep & Cognit, Singapore, Singapore, [Zhou, J. H.] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Sleep & Cognit, Singapore, Singapore, [Ortinau, C.] Washington Univ, Dept Pediat, St Louis, MO 63130 USA, [Ossenkoppele, R.] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC, Dept Neurol,Amsterdam Neurosci, Amsterdam, Netherlands, [Ossenkoppele, R.] Lund Univ, Clin Memory Res Unit, Lund, Sweden, [Palaniyappan, L.] Univ Western Ontario, Robarts Res Inst, London, ON, Canada, [Palaniyappan, L.] Univ Western Ontario, Brain & Mind Inst, London, ON, Canada, [Pan, P. M.] Fed Univ Sao Poalo UNIFESP, Dept Psychiat, Sao Poalo, Brazil, [Pan, P. M.] Natl Inst Dev Psychiat Children & Adolescents INP, Sao Poalo, Brazil, [Zugman, A.] Natl Inst Dev Psychiat Children & Adolescents INP, Sao Poalo, Brazil, [Pantelis, C.] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Carlton, Vic, Australia, [Pantelis, C.] Melbourne Hlth, Carlton, Vic, Australia, [Pantelis, C.] Univ Melbourne, Melbourne Sch Engn, Parkville, Vic, Australia, [Pantelis, C.] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia, [Park, M. M.] Western Univ, Schulich Sch Med & Dent, Dept Psychiat, London, ON, Canada, [Rollins, C. K.] Univ Montreal, Dept Psychiat, Fac Med, Montreal, PQ, Canada, [Rollins, C. K.] Univ Montreal, CHU St Justine, Montreal, PQ, Canada, [Romero-Garcia, R.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada, [Romero-Garcia, R.] Univ Toronto, Dept Psychol, Toronto, ON, Canada, [Rosenberg, M. D.] Univ Toronto, Dept Physiol, Toronto, ON, Canada, [Rosenberg, M. D.] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada, [Paz-Linares, D.] Cuban Neurosci Ctr, Havana, Cuba, [Pichet Binette, A.] McGill Univ, Fac Med, Dept Psychiat, Montreal, PQ, Canada, [Villeneuve, S.] McGill Univ, Fac Med, Dept Psychiat, Montreal, PQ, Canada, [Pichet Binette, A.] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada, [Villeneuve, S.] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada, [Qiu, J.] Southwest Univ, Sch Psychol, Chongqing, Peoples R China, [Qiu, A.] Natl Univ Singapore, N1 Inst Hlth, Dept Biomed Engn, Singapore, Singapore, [Rittman, T.] Univ Cambridge, Dept Clin Neurosci, Cambridge, England, [Tsvetanov, K. A.] Univ Cambridge, Dept Clin Neurosci, Cambridge, England, [Rollins, C. K.] Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA, [Rollins, C. K.] Boston Childrens Hosp, Dept Neurol, Boston, MA USA, [Romero-Garcia, R.] Univ Seville, Dpto Fisiol Med & Biofis, Inst Biomed Sevilla IBiS HUVR CSIC, Seville, Spain, [Rosenberg, M. D.] Univ Chicago, Dept Psychol, 5848 S Univ Ave, Chicago, IL 60637 USA, [Rosenberg, M. D.] Univ Chicago, Inst Neurosci, Chicago, IL USA, [Rowitch, D. H.] Univ Cambridge, Dept Paediat, Cambridge, England, [Rowitch, D. H.] Univ Cambridge, Wellcome MRC Cambridge Stem Cell Inst, Cambridge, England, [Salum, G. A.] Univ Fed Rio Grande Sul UFRGS, Hosp Clin Porto Alegre, Dept Psychiat, Porto Alegre, RS, Brazil, [Salum, G. A.] Natl Inst Dev Psychiat INPD, Sao Paulo, Brazil, [Schaare, H. L.] Max Planck Inst Human Cognit & Brain Sci, Otto Hahn Grp Cognit Neurogenet, Leipzig, Germany, [Schaare, H. L.] Res Ctr Juelich, Inst Neurosci & Med INM 7 Brain & Behav, Julich, Germany, [Schultz, A. P.] Massachusetts Gen Hosp, Dept Radiol, Athinoula Martinos Ctr Biomed Imaging, Charlestown, MA USA, [Schumann, G.] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Ctr Populat Neurosci & Stratified Med PONS, Shanghai, Peoples R China, [Schumann, G.] Charite Campus Mitte, Dept Psychiat & Psychotherapy, Charite Mental Hlth, PONS Ctr, Berlin, Germany, [Scholl, M.] Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden, [Scholl, M.] Univ Gothenburg, Dept Psychiat & Neurochem, Gothenburg, Sweden, [Scholl, M.] UCL, Queens Sq Inst Neurol, Dementia Res Ctr, London, England, [Sharp, D.] UK Dementia Res Inst, Care Res & Technol Ctr, London, England, [Shinohara, R. T.] Univ Penn, Perelman Sch Med, Dept Radiol, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA, [Smyser, C. D.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA, [Smyser, C. D.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA, [Smyser, C. D.] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA, [Stein, D. J.] Univ Cape Town, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa, [Stein, D. J.] Univ Cape Town, Neurosci Inst, Cape Town, South Africa, [Stolicyn, A.] Univ Edinburgh, Ctr Clin Brain Sci, Div Psychiat, Edinburgh, Midlothian, Scotland, [Whalley, H. C.] Univ Edinburgh, Ctr Clin Brain Sci, Div Psychiat, Edinburgh, Midlothian, Scotland, [Toro, R.] Inst Pasteur, Dept Neurosci, Paris, France, [Traut, N.] Inst Pasteur, Dept Neurosci, Paris, France, [Traut, N.] Univ Paris 05, Ctr Res & Interdisciplinar CRI, Paris, France, [Tsvetanov, K. A.] Univ Cambridge, Dept Psychol, Cambridge, England, [Turk-Browne, N. B.] Yale Univ, Wu Tsai Inst, New Haven, CT USA, [Tuulari, J. J.] Univ Turku, Dept Clin Med, Turku, Finland, [Tuulari, J. J.] Univ Turku, Turku Coll Sci Med & Technol, Turku, Finland, [Tzourio, C.] Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, CHU Bordeaux, U1219,INSERM, Bordeaux, France, [Vachon-Presseau, E.] McGill Univ, Fac Dent Med & Oral Hlth Sci, Montreal, PQ, Canada, [Valdes-Sosa, P. A.] McGill Univ, Alan Edwards Ctr Res Pain AECRP, Montreal, PQ, Canada, [Valk, S. L.] Forschungszentrum Julich, Inst Neurosci & Med 7, Julich, Germany, [Valk, S. L.] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany, [van Amelsvoort, T.] Maastricht Univ, Dept Psychiat & Neurosychol, Maastricht, Netherlands, [Vandekar, S. N.] Vanderbilt Univ, Dept Biostat, 221 Kirkland Hall, Nashville, TN 37235 USA, [Villeneuve, S.] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN USA, [Villringer, A.] Univ Leipzig, Clin Cognit Neurol, Med Ctr, Leipzig, Germany, [Witte, A. V.] Univ Leipzig, Clin Cognit Neurol, Med Ctr, Leipzig, Germany, [Zuo, X. N.] Univ Leipzig, Clin Cognit Neurol, Med Ctr, Leipzig, Germany, [Wang, Y. S.] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China, [Yang, N.] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China, [Yeo, B.] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China, [Zuo, X. N.] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China, [Wang, Y. S.] Beijing Normal Univ, IDG McGovern Inst Brain Res, Dev Populat Neuroscience Res Ctr, Beijing, Peoples R China, [Yang, N.] Beijing Normal Univ, IDG McGovern Inst Brain Res, Dev Populat Neuroscience Res Ctr, Beijing, Peoples R China, [Zuo, X. N.] Beijing Normal Univ, IDG McGovern Inst Brain Res, Dev Populat Neuroscience Res Ctr, Beijing, Peoples R China, [Wang, Y. S.] Natl Basic Sci Data Ctr, Beijing, Peoples R China, [Yang, N.] Natl Basic Sci Data Ctr, Beijing, Peoples R China, [Zuo, X. N.] Natl Basic Sci Data Ctr, Beijing, Peoples R China, [Wang, Y. S.] Chinese Acad Sci, Res Ctr Lifespan Dev Brain & Mind, Inst Psychol, Beijing, Peoples R China, [Yang, N.] Chinese Acad Sci, Res Ctr Lifespan Dev Brain & Mind, Inst Psychol, Beijing, Peoples R China, [Westman, E.] Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden, [Witte, A. V.] Univ Leipzig, CRC 1052 Obes Mech, Fac Med, Leipzig, Germany, [Zhou, J. H.] Natl Univ Singapore, Dept Elect & Comp Engn, Singapore, Singapore, [Yeo, B.] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Sleep & Cognit, Singapore, Singapore, [Yeo, B.] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Translat MR Res, Singapore, Singapore, [Yeo, B.] Natl Univ Singapore, N1 Inst Hlth, Singapore, Singapore, [Yeo, B.] Natl Univ Singapore, Inst Digital Med, Singapore, Singapore, [Yun, H.] Natl Univ Singapore, Integrat Sci & Engn Programme ISEP, Singapore, Singapore, [Zar, H. J.] Univ Melbourne, Dept Biomed Engn, Melbourne, Vic, Australia, [Zhou, J. H.] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Translat Magnet Resonance Res, Singapore, Singapore, [Ziauddeen, H.] Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, Cambridge, England, [Zugman, A.] NIMH, NIH, Bethesda, MD 20892 USA, [Zugman, A.] Escola Paulista Med, Dept Psychiat, Sao Paulo, Brazil, [Zuo, X. N.] Nanning Normal Univ, Sch Educ Sci, Key Lab Brain & Educ, Nanning, Peoples R China, British Academy Postdoctoral fellowship, NIMH, UKRI Medical Research Council, NIHR Cambridge Biomedical Research Centre, NIHR Senior Investigator award, MRC research infrastructure award, Commonwealth Scientific and Industrial Research Organisation (CSIRO), and Ontario Brain Institute
Subjects: 631/378/2649, OpenPain Project, KNE96, Growth, Psychiatric-disorders, DISEASE, 3R-BRAIN, Brain charts, MRI Brain, OASIS-3, Disease, CCNP, 631/378/2571, UMN BCP, Multidisciplinary, medicine.diagnostic_test, PSYCHIATRIC-DISORDERS, article, Brain, Human brain, ASSOCIATION, Magnetic Resonance Imaging, Harvard Aging Brain Study, The Mayo Clinic Study of Aging, NSPN, medicine.anatomical_structure, GROWTH, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], ddc:500, BURDEN, WHITE-MATTER, FinnBrain, Harvard Aging Brain Study, Organization, Mri, MRI, medicine.medical_specialty, Concurrent validity, MODELS, Cam-CAN, Longevity, CALM Team, POND, Neuroimaging, Burden, ORGANIZATION, AIBL, The PREVENT-AD Research Group, VETSA, Cortical thickness, Association, Physical medicine and rehabilitation, FinnBrain, IMAGEN, KNE96, White-matter, medicine, Humans, ASRB, 631/378/1689, COBRE, business.industry, 631/378/2611, Brain morphometry, Neurosciences, Alzheimer’s Disease Repository Without Borders Investigators, Magnetic resonance imaging, Alzheimer’s Disease Neuroimaging Initiative, Anthropometry, Body Height, Brain growth, Birth, 59/57, Normative, IMAGEN, ENIGMA Developmental Brain Age working group, NSPN, business, CCNP, 3R-BRAIN, CORTICAL THICKNESS, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, The PREVENT-AD Research Group, VETSA, Bullmore, E.T
Abstract: Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes., R.A.I.B. was supported by a British Academy Postdoctoral fellowship and by the Autism Research Trust. J. Seidlitz was supported by NIMH T32MH019112-29 and K08MH120564. S.R.W. was funded by UKRI Medical Research Council MC_UU_00002/2 and was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). E.T.B. was supported by an NIHR Senior Investigator award and the Wellcome Trust collaborative award for the Neuroscience in Psychiatry Network. A.F.A.-B. was supported by NIMH K08MH120564. Data were curated and analysed using a computational facility funded by an MRC research infrastructure award (MR/M009041/1) to the School of Clinical Medicine, University of Cambridge and supported by the mental health theme of the NIHR Cambridge Biomedical Research Centre.
Published: 2022

9. Moderate to Severe Psoriasis in Pediatric and Young Patients: The BIOBADADERM Registry Experience

Author: Benito, L. M. Nieto, Carretero, G., Rivera-Diaz, R., Carrascosa, J. M., Dauden, E., de la Cueva, P., Sahuquillo-Torralba, A., Herrera-Acosta, E., Baniandres-Rodriguez, O., Lopez-Estebaranz, J. L., Belinchon, I, Riera-Monroig, J., Ferran, M., Gomez-Garcia, F. J., Mateu, A., Rodriguez, L., Vilar-Alejo, J., Garcia-Donoso, C., Ballesca, F., Velasco, Llamas-M, Botella-Estrada, R., Herrera-Ceballos, E., Ruiz-Genao, D. P., Descalzo, M. A., Garcia-Doval, I, BIOBADADERM Study Grp, [Benito, L. M. Nieto] Hosp Gen Univ Gregorio Maranon, Dept Dermatol, CEIMI, Madrid, Spain, [Baniandres-Rodriguez, O.] Hosp Gen Univ Gregorio Maranon, Dept Dermatol, CEIMI, Madrid, Spain, [Carretero, G.] Hosp Univ Gran Canaria Dr Negrin, Dept Dermatol, Las Palmas Gran Canaria, Islas Canarias, Spain, [Vilar-Alejo, J.] Hosp Univ Gran Canaria Dr Negrin, Dept Dermatol, Las Palmas Gran Canaria, Islas Canarias, Spain, [Rivera-Diaz, R.] Hosp Univ 12 Octubre, Dept Dermatol, Madrid, Spain, [Garcia-Donoso, C.] Hosp Univ 12 Octubre, Dept Dermatol, Madrid, Spain, [Carrascosa, J. M.] Hosp Univ Germans Trias I Pujol, Dept Dermatol, Badalona, Spain, [Ballesca, F.] Hosp Univ Germans Trias I Pujol, Dept Dermatol, Badalona, Spain, [Carrascosa, J. M.] Univ Autonoma Barcelona, Barcelona, Spain, [Ballesca, F.] Univ Autonoma Barcelona, Barcelona, Spain, [Dauden, E.] Hosp Univ La Princesa, Inst Invest Sanitaria La Princesa IIS IP, Dept Dermatol, Madrid, Spain, [Velasco, Llamas-M] Hosp Univ La Princesa, Inst Invest Sanitaria La Princesa IIS IP, Dept Dermatol, Madrid, Spain, [de la Cueva, P.] Hosp Univ Infanta Leonor, Dept Dermatol, Madrid, Spain, [Sahuquillo-Torralba, A.] Univ Valencia, Dept Dermatol, Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe IIS La Fe,Fac Med, Valencia, Spain, [Botella-Estrada, R.] Univ Valencia, Dept Dermatol, Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe IIS La Fe,Fac Med, Valencia, Spain, [Herrera-Acosta, E.] Hosp Univ Virgen de la Victoria, Dept Dermatol, Malaga, Spain, [Herrera-Ceballos, E.] Hosp Univ Virgen de la Victoria, Dept Dermatol, Malaga, Spain, [Lopez-Estebaranz, J. L.] Hosp Univ Fdn Alcorcon, Dept Dermatol, Madrid, Spain, [Ruiz-Genao, D. P.] Hosp Univ Fdn Alcorcon, Dept Dermatol, Madrid, Spain, [Belinchon, I] Hosp Gen Univ Alicante ISABIAL UMH, Dept Dermatol, Alicante, Spain, [Riera-Monroig, J.] UB, Dept Dermatol, Hosp Clin Barcelona, Barcelona, Spain, [Ferran, M.] Hosp Mar, Dept Dermatol, Parc Salut Mar, Barcelona, Spain, [Gomez-Garcia, F. J.] Hosp Univ Reina Sofia, Dept Dermatol, Cordoba, Spain, [Mateu, A.] Hosp Univ Doctor Peset, Dept Dermatol, Valencia, Spain, [Rodriguez, L.] Hosp Virgen del Rocio, Dept Dermatol, Seville, Spain, [Descalzo, M. A.] AEDV, Fdn Piel Sana, Unidad Invest, Madrid, Spain, [Garcia-Doval, I] AEDV, Fdn Piel Sana, Unidad Invest, Madrid, Spain, [Garcia-Doval, I] Complexo Hosp Univ Vigo, Dept Dermatol, Vigo, Pontevedra, Spain, Spanish Agency of Medicines and Medical Devices (AEMPS), Abbott/AbbVie, Amgen, Almirall, Janssen, Novartis, and UCB
Subjects: Psoriasis, Registries, Safety, BIOBADADERM, Childhood
Abstract: Childhood-onset psoriasis generally follows an indolent course but patients with moderate or severe disease may require systemic treatment. The aim of this study was to determine the relative proportion of children and young people aged up to 21 years with moderate to severe psoriasis in the BIOBADADERM registry and to analyze the characteristics of these patients, treatments used, and adverse events. Of the 3946 patients in the registry, 24 were aged 21 years or younger. The mean age of this group when they started treatment upon registration on Biobadaderm was 16.1 years and the mean Psoriasis Area and Severity Index was 9.4. In 67% the first treatment recorded was with a conventional systemic drug. Treatment was discontinued in 14 patients (58%) due to adverse events or a loss or lack of effectiveness. In conclusion, the BIOBADADERM registry shows that young people account for a small proportion of psoriasis patients receiving systemic treatment, and they are more likely to be treated using conventional systemic drugs. (C) 2021 AEDV. Published by Elsevier Espana, S.L.U.
Published: 2022

10. Melatonin synthesis in and uptake by mitochondria: implications for diseased cells with dysfunctional mitochondria

Author: Ramaswamy Sharma, Debora Aparecida Pires de Campos Zuccari, Carmen Rodríguez, Luiz Gustavo de Almeida Chuffa, Russel J. Reiter, Walter Manucha, UT Hlth San Antonio, Fac Med Sao Jose Rio Preto, Universidade Estadual Paulista (Unesp), Natl Univ 14 Cuyo, and Fac Med
Subjects: zygote, oxidative phosphorylation, glycolytics, Pyruvate Dehydrogenase Complex, Dysfunctional family, Oxidative phosphorylation, Mitochondrion, Oxidative Phosphorylation, superoxide dismutase 2, pyruvate dehydrogenase, Acetyl Coenzyme A, Drug Discovery, Humans, aerobic glycolysis, Melatonin, reactive oxygen species, Pharmacology, chemistry.chemical_classification, Reactive oxygen species, Zygote, Chemistry, hypoxia-inducible factor 1&#945, Pyruvate dehydrogenase complex, Warburg effect, Mitochondria, Cell biology, Anaerobic glycolysis, Molecular Medicine
Abstract: Made available in DSpace on 2021-06-25T12:32:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-05 UT Hlth San Antonio, Dept Cell Syst & Anat, San Antonio, TX 78229 USA Fac Med Sao Jose Rio Preto, Lab Invest Mol Canc, Ave Brigadeiro Faria Lima 5416, BR-15090000 Sao Paulo, Brazil IBB UNESP, Dept Biol Estrutural & Func, Setor Anat, Inst Biociencias, Campus Botucatu, BR-18618689 Sao Paulo, Brazil Natl Univ 14 Cuyo, Med Sci Coll, Pathol Dept, Pharmacol Area, RA-5500 Mendoza, Argentina Fac Med, Dept Morfol & Biol Celular, C Julian Claveria 6, Oviedo 33006, Spain IBB UNESP, Dept Biol Estrutural & Func, Setor Anat, Inst Biociencias, Campus Botucatu, BR-18618689 Sao Paulo, Brazil
Published: 2021

11. The editorial team reports on the year 2021 and sets new goals for 2022: comply with the 2020-2022 Strategic Plan of the Spanish Journal of Human Nutrition and Dietetics

Author: Munoz, Eva Ma Navarrete, Bonilla, Diego A., Gamero, Amparo, Perez-Lopez, Alberto, Petermann-Rocha, Fanny, Fernandez-Villa, Tania, Lozano-Lorca, Macarena, Perez-Esteve, Edgar, Gonzalez, Edna J. Nava, Duarte Junior, Miguel Angelo, Benitez, Nestor, Lopez, Saby Camacho, Almendra-Pegueros, Rafael, [Munoz, Eva Ma Navarrete] Univ Miguel Hernandez, Dept Patol & Cirugia, Grp Invest Terapia Ocupac, Elche, Spain, [Bonilla, Diego A.] Univ Miguel Hernandez, Dept Patol & Cirugia, Grp Invest Terapia Ocupac, Elche, Spain, [Munoz, Eva Ma Navarrete] Inst Invest Sanitaria & Biomed Alicante ISABIAL, Alicante, Spain, [Bonilla, Diego A.] DBSS Int SAS, Div Invest Dynam Business & Sci Soc, Bogota, Colombia, [Bonilla, Diego A.] Univ CES, Fac Ciencias Nutr & Alimentos, Grp Invest Nutral, Medellin, Colombia, [Gamero, Amparo] Univ Valencia, Fac Farm, Dept Med Prevent & Salud Publ, Ciencias Alimentac Toxicol & Med Legal, Valencia, Spain, [Perez-Lopez, Alberto] Univ Alcala, Fac Med & Ciencias Salud, Dept Ciencias Biomed, Area Educ Fis & Deport, Madrid, Spain, [Petermann-Rocha, Fanny] Univ Diego Port, Fac Med, Santiago, Chile, [Petermann-Rocha, Fanny] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland, [Fernandez-Villa, Tania] Univ Leon, Grp Invest Interacc Gen Ambiente & Salud GIIGAS, Inst Biomed IBIOMED, Leon, Spain, [Fernandez-Villa, Tania] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain, [Lozano-Lorca, Macarena] Univ Granada, Fac Ciencias Salud Ceuta, Dept Enfermeria, Ceuta, Spain, [Lozano-Lorca, Macarena] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain, [Perez-Esteve, Edgar] Univ Politecn Valencia, Dept Tecnol Alimentos, Valencia, Spain, [Gonzalez, Edna J. Nava] Univ Autonoma Nuevo Leon, Fac Salud Publ & Nutr, Monterrey, NL, Mexico, [Duarte Junior, Miguel Angelo] Univ Autonoma Madrid, Fac Med, Dept Med Prevent & Salud Publ, Madrid, Spain, [Benitez, Nestor] Serv Canario Salud, Direcc Gen Salud Publ, Santa Cruz De Tenerife, Spain, [Benitez, Nestor] Univ Isabel I, Fac Ciencias Salud, Burgos, Spain, [Lopez, Saby Camacho] Nutrir Mexico, Mexico City, DF, Mexico, and [Almendra-Pegueros, Rafael] UASLP, Fac Med, Lab Invest Traslac Farmacol, San Luis Potosi, San Luis Potosi, Mexico
Subjects: Food, Education
Published: 2022

12. Ethical communication in social networks for nutrition

Author: Camacho-Lopez, Saby, Nava-Gonzalez, Edna J., Apolinar-Jimenez, Evelia, Almendra-Pegueros, Rafael, Perez-Lopez, Alberto, Gamero, Amparo, Kammar-Garcia, Ashuin, Angelo Duarte, Miguel, Jr., Fernandez Villa, Tania, Perez-Esteve, Edgar, Bonilla, Diego A., Lozano-Lorca, Macarena, Navarrete-Munoz, Eva Maria, [Camacho-Lopez, Saby] Nutrir Mexico, Ciudad De Mexico, Mexico, [Nava-Gonzalez, Edna J.] Univ Autonoma Nuevo Leon, Fac Salud Publ & Nutr, Monterrey, Mexico, [Apolinar-Jimenez, Evelia] Secretaria Salud Mexico, Dept Invest, Hosp Reg Alta Especialidad Bajio, Unidad Metab & Nutr, Mexico City, DF, Mexico, [Almendra-Pegueros, Rafael] UASLP, Lab Invest Traslac Farmacol, Fac Med, San Luis Potosi, San Luis Potosi, Mexico, [Perez-Lopez, Alberto] Univ Alcala, Fac Med & Ciencias Salud, Dept Ciencias Biomed, Area Educ Fis & Deport, Madrid, Spain, [Gamero, Amparo] Univ Valencia, Fac Farm, Dept Med Prevent & Salud Publ Ciencias Alimentac, Valencia, Spain, [Kammar-Garcia, Ashuin] Inst Nacl Geriatria, Direcc Invest, Ciudad De Mexico, Mexico, [Angelo Duarte, Miguel, Jr.] Univ Autonoma Madrid, Fac Med, Dept Med Prevent & Salud Publ, Madrid, Spain, [Fernandez Villa, Tania] Univ Leon, Inst Invest Biomed IBIOMED, Grp Invest Interacc Gen Ambiente & Salud GIIGAS, Leon, Spain, [Fernandez Villa, Tania] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain, [Perez-Esteve, Edgar] Univ Politecncia Valencia, Dept Tecnol Alimentos, Valencia, Spain, [Bonilla, Diego A.] Dynam Business & Sci Soc DBSS Int SAS, Div Invest, Bogota, Colombia, [Bonilla, Diego A.] Univ CES, Fac Ciencias Nutr & Alimentos, Grp Invest Nutral, Medellin, Colombia, [Lozano-Lorca, Macarena] Univ Granada, Fac Ciencias Salud Ceuta, Dept Enfermeria, Ceuta, Spain, [Lozano-Lorca, Macarena] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain, [Navarrete-Munoz, Eva Maria] Univ Miguel Hernandez, Dept Patol & Cirugia, Grp Invest Terapia Ocupac InTeO, Alicante, Spain, and [Navarrete-Munoz, Eva Maria] Inst Invest Sanitaria & Biomed Alicante ISABIAL, Alicante, Spain
Published: 2022

13. Immunisation schedule of the Pediatric Spanish Association: 2022 recommendations

Author: Alvarez Garcia, Francisco Jose, Cilleruelo Ortega, Maria Jose, Alvarez Aldean, Javier, Garces-Sanchez, Maria, Garrote Llanos, Elisa, Iofrio de Arce, Antonio, Montesdeoca Melian, Abian, Navarro Gomez, Maria Luisa, Pineda Solas, Valentin, Rivero Calle, Irene, Ruiz-Contreras, Jesus, Serrano Marchuet, Pepe, Asociacion Espanola Pediat CAV-AEP, [Alvarez Garcia, Francisco Jose] Univ Oviedo, Ctr Salud Llanera, Dept Med, Oviedo, Asturias, Spain, [Cilleruelo Ortega, Maria Jose] Univ Autonoma Madrid, Hosp Univ Puerta de Hierro Majadahonda, Serv Pediat, Dept Pediat,Fac Med, Madrid, Spain, [Alvarez Aldean, Javier] Hosp Costa Sol, Serv Pediat, Malaga, Spain, [Garces-Sanchez, Maria] FISABIO, Ctr Salud Nazaret, Area Vacunas, Valencia, Spain, [Garrote Llanos, Elisa] Univ Basque Country, Hosp Univ Basurto, Fac Med, Secc Infectol,UPV EHU, Bilbao, Pais Vasco, Spain, [Iofrio de Arce, Antonio] Ctr Salud Ranero, Murcia, Spain, [Montesdeoca Melian, Abian] Ctr Salud Guanarteme, Las Palmas Gran Canaria, Spain, [Navarro Gomez, Maria Luisa] Univ Complutense Madrid, Hosp Univ Gregorio Maranon, Serv Pediat, Dept Pediat,Fac Med, Madrid, Spain, [Pineda Solas, Valentin] Univ Autonoma Barcelona, Secc Infectol Pediat, Hosp Univ Parc Tauli Sabadell, Barcelona, Spain, [Rivero Calle, Irene] Hosp Clin Univ Santiago de Compostela, Infectol & Traslac, Secc Pediat Clin, Grp Genet Vacunas Infecc & Pediat GENVIP, La Coruna, Spain, [Ruiz-Contreras, Jesus] Univ Complutense Madrid, Hosp Univ 12 Octubre, Serv Pediat, Dept Pediat,Fac Med, Madrid, Spain, and [Serrano Marchuet, Pepe] Equipo Pediat Terr Garraf, Barcelona, Spain
Subjects: Vaccines, Adolescent, Pneumococcal conjugate vaccine, Infant, Invasive meningococcal disease, Immunogenicity, Time, Impact, Rubella-varicella vaccine, Vaccine preventable diseases, Adults, Safety, Child, Inmunisation schedule, Children, Infants
Abstract: After reviewing the best available scientific information, CAV-AEP publishes their new recommendations to protect pregnant women, children and adolescents living in Spain through vaccination.The same recommendations as the previous year regarding hexavalent vaccines, pneumococcal conjugate vaccine of 13 serotypes, booster with tetanus, diphtheria, pertussis and inactivated poliomyelitis (Tdpa-IPV) at 6 years and with tetanus, diphtheria and pertussis (Tdpa) at 12-14 years and pregnant women from week 27 (from week 20 if there is a high risk of preterm delivery).Also with rotavirus, tetraantigenic meningococcal B (2 + 1), meningococcal quadrivalent (MenACWY), MMR, varicella and human papillomavirus (HPV) vaccines, for both genders.As novelties this year the CAV-AEP recommends:.Influenza vaccination from 6 to 59 months of age whenever feasible and does not harm the vaccination program aimed at people at higher risk.According to official national recommendations, the CAV-AEP recommends the systematic use of COVID mRNA vaccines since 5 years old. (C) 2021 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
Published: 2022

14. Asymmetries of the Muscle Mechanical Properties of the Pelvic Floor in Nulliparous and Multiparous Women, and Men: A Cross-Sectional Study

Author: Daiana Priscila Rodrigues-de-Souza, Ana Carolina Sartorato Beleza, Lourdes García-Luque, Sandra Alcaraz-Clariana, Cristina Carmona-Pérez, Amaranta De Miguel-Rubio, María Teresa Garzón-Alfaro, Inés Cruz-Medel, Juan Luis Garrido-Castro, Francisco Alburquerque-Sendín, [Priscila Rodrigues-de-Souza, Daiana] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [Garcia-Luque, Lourdes] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [Alcaraz-Clariana, Sandra] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [Carmona-Perez, Cristina] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [De Miguel-Rubio, Amaranta] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [Teresa Garzon-Alfaro, Maria] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [Cruz-Medel, Ines] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [Alburquerque-Sendin, Francisco] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Phys Therapy, Cordoba 14004, Spain, [Sartorato Beleza, Ana Carolina] Univ Fed Sao Carlos, Dept Phys Therapy, Lab Women Hlth LAMU, Rodovia Washington Luis Km 235, BR-13565905 Sao Carlos, SP, Brazil, [Luis Garrido-Castro, Juan] Univ Cordoba, Dept Comp Sci & Numer Anal, Rabanales Campus, Cordoba 14071, Spain, [Luis Garrido-Castro, Juan] Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain, [Alburquerque-Sendin, Francisco] Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain, and Research Plan of the University of Cordoba, Spain
Subjects: Tissue, Pfdi-20, Physics and Astronomy (miscellaneous), pelvic floor disorders, manual tonometry, childbirth, tissue damage, General Mathematics, Pelvic floor disorders, Biomechanical properties, Stiffness, Impact, Age, Chemistry (miscellaneous), Childbirth, Validation, Computer Science (miscellaneous), Issue damage, Pfiq-7, Manual tonometry, Delivery, Stress urinary-incontinence
Abstract: This study aimed to identify if the muscle mechanical properties (MMPs) of both sides of pelvic floor muscles (PFMs) are symmetrical in different populations of both sexes. Between-sides comparisons of MMPs of PFMs, assessed with manual myotonometry, were performed in three groups, with 31 subjects each, composed of healthy nulliparous women (without any type of delivery or pregnancy), multiparous women (with at least two vaginal deliveries), and healthy adult men. Intra-group correlations between MMPs and age, body mass index (BMI), or clinical state of pelvic floor were also obtained. The nulliparous women and the men showed no between-sides differences in any MMP of PFMs. However, the multiparous women showed that the right side displayed less frequency (−0.65 Hz, 95% CI = −1.01, −0.20) and decrement (0.5, 95% CI = 0.11, 0.01), and more relaxation (1.00 ms, 95% CI = 0.47, 1.54) and creep (0.07 De, 95% CI = 0.03, 0.11), than the left side. Further, MMPs were related to age, sex, and BMI, also depending on the population, with the multiparous women being the only group with some between-sides asymmetries, which in this case were positive and of fair intensity for the left side of the PFMs, between BMI, and frequency and stiffness (rho Spearman coefficient: 0.365 and 0.366, respectively). The symmetry of MMPs of the PFMs could depend on the subject’s condition. Multiparous women show a higher tendency to asymmetries than nulliparous women and men, which should be considered in research and clinical settings.
Published: 2022

15. Intra- and Interobserver Reliability of Superb Microvascular Imaging (SMI) Doppler for Assessing Placental Microvasculature

Author: Garcia-Jimenez, Rocio, Antonio Garcia-Mejido, Jose, Valero, Irene, Fernandez-Palacin, Ana, Borrero, Carlota, Antonio Sainz-Bueno, Jose, Universidad de Sevilla. Departamento de Cirugía, Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública, [Garcia-Jimenez, Rocio] Valme Univ Hosp, Dept Obstet & Gynecol, Seville 41014, Spain, [Antonio Garcia-Mejido, Jose] Valme Univ Hosp, Dept Obstet & Gynecol, Seville 41014, Spain, [Valero, Irene] Valme Univ Hosp, Dept Obstet & Gynecol, Seville 41014, Spain, [Borrero, Carlota] Valme Univ Hosp, Dept Obstet & Gynecol, Seville 41014, Spain, [Antonio Sainz-Bueno, Jose] Valme Univ Hosp, Dept Obstet & Gynecol, Seville 41014, Spain, [Antonio Garcia-Mejido, Jose] Univ Seville, Fac Med, Dept Obstet & Gynecol, Seville 41009, Spain, [Borrero, Carlota] Univ Seville, Fac Med, Dept Obstet & Gynecol, Seville 41009, Spain, [Antonio Sainz-Bueno, Jose] Univ Seville, Fac Med, Dept Obstet & Gynecol, Seville 41009, Spain, and [Fernandez-Palacin, Ana] Univ Seville, Dept Prevent Med & Publ Hlth, Biostat Unit, Seville 41014, Spain
Subjects: Superb microvascular imaging, Reproductive Medicine, Vascularization, Angiography, Obstetrics and Gynecology, SMI Doppler, Growth, Placental microvasculature, Reliability, Reproducibility
Abstract: Objective: Superb Microvascular Imaging (SMI) Doppler is a novel technique. We aim to evaluate intra- and interobserver reliability of SMI Doppler for the assessment of normal placental microvasculature. Materials and Methods: A prospective observational study was conducted including 11 pregnant patients. Ultrasonography placental assessment was performed on 28-weeks pregnant patients, by two expert examiners using SMI Doppler in one single visit. To evaluate interobserver reliability, the first examiner took measurements using SMI Doppler, followed then by the second examiner. Afterwards, the first examiner performed a second evaluation, in order to assess intraobserver reliability. Intraclass correlation coefficients (ICC) and Cohen's Kappa coefficient, and their 95% confidence intervals, were estimated for quantitative and qualitative parameters, respectively. Results: Intraobserver reliability was found to be excellent for all quantitative parameters, with all ICC values above 0.97. For qualitative variables, excellent reliability was obtained for the number of secondary villi, while the number of tertiary villi had an adequate reliability with a Cohen's Kappa coefficient of 0.792 (95% CI 0.38-1.17; p = 0.007). Interobserver ICCs ranged from 0.92 to 1.00 for all quantitative parameters, thus finding excellent interobserver reliability for all of them. An excellent reliability was also obtained for the number of secondary villi, while the reliability for the number of tertiary villi was found to be adequate. Conclusions: Our findings show that placental microvasculature measurements obtained by a single or two different examiners are reliable and reproducible. The good intra- and interobserver reliability results of SMI Doppler showed in our study stress the value of this technique in the evaluation of placental microvasculature, and thus research in this field is the step forward for the assessment of placental insufficiency.
Published: 2022

16. Evaluation of poly (lactic-co-glycolic acid) nanoparticles to improve the therapeutic efficacy of paclitaxel in breast cancer

Author: Laura Cabeza, Mazen M. El-Hammadi, Raul Ortiz, Maria D. Cayero-Otero, Julia Jiménez-López, Gloria Perazzoli, Lucia Martin-Banderas, Jose M. Baeyens, Consolación Melguizo, Jose Prados, Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla, Junta de Andalucía, Instituto de Salud Carlos III, [Cabeza, Laura] Univ Granada, Ctr Biomed Res CIBM, Inst Biopathol & Regenerat Med IBIMER, Granada 18100, Spain, [Ortiz, Raul] Univ Granada, Ctr Biomed Res CIBM, Inst Biopathol & Regenerat Med IBIMER, Granada 18100, Spain, [Jimenez-Lopez, Julia] Univ Granada, Ctr Biomed Res CIBM, Inst Biopathol & Regenerat Med IBIMER, Granada 18100, Spain, [Perazzoli, Gloria] Univ Granada, Ctr Biomed Res CIBM, Inst Biopathol & Regenerat Med IBIMER, Granada 18100, Spain, [Melguizo, Consolacion] Univ Granada, Ctr Biomed Res CIBM, Inst Biopathol & Regenerat Med IBIMER, Granada 18100, Spain, [Prados, Jose] Univ Granada, Ctr Biomed Res CIBM, Inst Biopathol & Regenerat Med IBIMER, Granada 18100, Spain, [Cabeza, Laura] Univ Granada, Fac Med, Dept Anat & Embryol, Granada 18071, Spain, [Ortiz, Raul] Univ Granada, Fac Med, Dept Anat & Embryol, Granada 18071, Spain, [Melguizo, Consolacion] Univ Granada, Fac Med, Dept Anat & Embryol, Granada 18071, Spain, [Prados, Jose] Univ Granada, Fac Med, Dept Anat & Embryol, Granada 18071, Spain, [Cabeza, Laura] Univ Granada, SAS, Biosanit Inst Granada Ibs GRANADA, Granada 18014, Spain, [Ortiz, Raul] Univ Granada, SAS, Biosanit Inst Granada Ibs GRANADA, Granada 18014, Spain, [Jimenez-Lopez, Julia] Univ Granada, SAS, Biosanit Inst Granada Ibs GRANADA, Granada 18014, Spain, [Perazzoli, Gloria] Univ Granada, SAS, Biosanit Inst Granada Ibs GRANADA, Granada 18014, Spain, [Melguizo, Consolacion] Univ Granada, SAS, Biosanit Inst Granada Ibs GRANADA, Granada 18014, Spain, [Prados, Jose] Univ Granada, SAS, Biosanit Inst Granada Ibs GRANADA, Granada 18014, Spain, [El-Hammadi, Mazen M.] Univ Seville, Fac Pharm, Dept Pharm & Pharmaceut Technol, Seville 41012, Spain, [Cayero-Otero, Maria D.] Univ Seville, Fac Pharm, Dept Pharm & Pharmaceut Technol, Seville 41012, Spain, [Martin-Banderas, Lucia] Univ Seville, Fac Pharm, Dept Pharm & Pharmaceut Technol, Seville 41012, Spain, [Baeyens, Jose M.] Univ Granada, Biomed Res Ctr CIBM, Inst Neurosci, Dept Pharmacol, Granada 18100, Spain, V Plan Propio (University of Seville), Consejeria de Salud de la Junta de Andalucia, and Instituto de Salud Carlos III (ISCIII)
Subjects: Albumin-bound paclitaxel, endocrine system, Paclitaxel, Cancer stem cells, Plga-based nanoparticles, technology, industry, and agriculture, Ovarian-cancer, Pharmaceutical Science, PLGA, General Medicine, Drug-delivery, Intracellular pharmacokinetics, General Biochemistry, Genetics and Molecular Biology, Mice xenografts, In-vitro, Breast cancer, Women, Mice xenografits, Tumor-targeted delivery, Challenges, Blood-pressure
Abstract: Financial support from the V Plan Propio (University of Seville). This work was also supported by Consejeria de Salud de la Junta de Andalucia (PI-0102-2017 and P18-HO-3882) and Instituto de Salud Carlos III (ISCIII) (Project PI19/01478) (FEDER)., Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, the most common type of cancer in women. However, this drug has serious limitations, including lack of tissue-specificity, poor water solubility, and the development of drug resistance. The transport of PTX in a polymeric nanoformulation could overcome these limitations. Methods: In this study, PLGA-PTX nanoparticles (NPs) were assayed in breast cancer cell lines, breast cancer stem cells (CSCs) and multicellular tumor spheroids (MTSs) analyzing cell cycle, cell uptake (Nile Red-NR-) and α-tubulin expression. In addition, PLGA-PTX NPs were tested in vivo using C57BL/6 mice, including a biodistribution assay. Results: PTX-PLGA NPs induced a significant decrease in the PTX IC50 of cancer cell lines (1.31 and 3.03-fold reduction in MDA-MB-231 and E0771 cells, respectively) and CSCs. In addition, MTSs treated with PTX-PLGA exhibited a more disorganized surface and significantly higher cell death rates compared to free PTX (27.9% and 16.3% less in MTSs from MCF-7 and E0771, respectively). PTX-PLGA nanoformulation preserved PTX’s mechanism of action and increased its cell internalization. Interestingly, PTX-PLGA NPs not only reduced the tumor volume of treated mice but also increased the antineoplastic drug accumulation in their lungs, liver, and spleen. In addition, mice treated with PTX-loaded NPs showed blood parameters similar to the control mice, in contrast with free PTX. Conclusion: These results suggest that our PTX-PLGA NPs could be a suitable strategy for breast cancer therapy, improving antitumor drug efficiency and reducing systemic toxicity without altering its mechanism of action., V Plan Propio (University of Seville), Junta de Andalucia PI-0102-2017 P18-HO-3882, Instituto de Salud Carlos III, European Commission PI19/01478
Published: 2022

17. Epidermodysplasia Verruciformis and Breast Cancer - Casual or Causal?

Author: Alejandro Molina-Leyva, Trinidad Montero-Vilchez, Antonio Martinez-Lopez, Andrea Rodriguez-Tejero, Jesus Tercedor-Sanchez, Salvador Arias-Santiago, [Montero-Vilchez, Trinidad] Hosp Univ Virgen de las Nieves, Dept Dermatol, Granada, Spain, [Martinez-Lopez, Antonio] Hosp Univ Virgen de las Nieves, Dept Dermatol, Granada, Spain, [Rodriguez-Tejero, Andrea] Hosp Univ Virgen de las Nieves, Dept Dermatol, Granada, Spain, [Tercedor-Sanchez, Jesus] Hosp Univ Virgen de las Nieves, Dept Dermatol, Granada, Spain, [Molina-Leyva, Alejandro] Hosp Univ Virgen de las Nieves, Dept Dermatol, Granada, Spain, [Arias-Santiago, Salvador] Hosp Univ Virgen de las Nieves, Dept Dermatol, Granada, Spain, [Montero-Vilchez, Trinidad] Inst Invest Biosanitaria Ibs Granada, Granada, Spain, [Martinez-Lopez, Antonio] Inst Invest Biosanitaria Ibs Granada, Granada, Spain, [Rodriguez-Tejero, Andrea] Inst Invest Biosanitaria Ibs Granada, Granada, Spain, [Tercedor-Sanchez, Jesus] Inst Invest Biosanitaria Ibs Granada, Granada, Spain, [Molina-Leyva, Alejandro] Inst Invest Biosanitaria Ibs Granada, Granada, Spain, [Arias-Santiago, Salvador] Inst Invest Biosanitaria Ibs Granada, Granada, Spain, [Montero-Vilchez, Trinidad] Univ Granada, Fac Med, Granada, Spain, [Martinez-Lopez, Antonio] Univ Granada, Fac Med, Granada, Spain, [Rodriguez-Tejero, Andrea] Univ Granada, Fac Med, Granada, Spain, [Tercedor-Sanchez, Jesus] Univ Granada, Fac Med, Granada, Spain, [Molina-Leyva, Alejandro] Univ Granada, Fac Med, Granada, Spain, and [Arias-Santiago, Salvador] Univ Granada, Fac Med, Granada, Spain
Subjects: Dermatology
Published: 2022

18. Differential chemotherapeutic regimen cytotoxicity against pancreatic cancer stem cells: a preliminary in vitro study

Author: Doello, Kevin, Quinonero, Francisco J., Perazzoli, Gloria, Gago, Lidia, Chico, Mari Angeles, Mesas, Cristina, [Doello, Kevin] Virgen Nieves Hosp, Med Oncol Serv, Granada 18014, Spain, [Quinonero, Francisco J.] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Gago, Lidia] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Chico, Mari Angeles] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Mesas, Cristina] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Quinonero, Francisco J.] Inst Biosanitario Granada ibs GRANADA, Granada 18014, Spain, [Perazzoli, Gloria] Inst Biosanitario Granada ibs GRANADA, Granada 18014, Spain, [Gago, Lidia] Inst Biosanitario Granada ibs GRANADA, Granada 18014, Spain, [Chico, Mari Angeles] Inst Biosanitario Granada ibs GRANADA, Granada 18014, Spain, [Mesas, Cristina] Inst Biosanitario Granada ibs GRANADA, Granada 18014, Spain, [Quinonero, Francisco J.] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Perazzoli, Gloria] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Mesas, Cristina] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, Andalusian Government, and Ministerio de Educacion Ciencia y Deporte y Competitividad (Spain)
Subjects: cancer stem cells, personalized therapy, chemotherapeutic protocols, Resistance, chemoresistance, Pancreatic cancer, Adenocarcinoma
Abstract: Introduction: Pancreatic cancer treatment in advanced stages is based on different chemotherapy regimens. Cancer stem cells are responsible for tumor chemoresistance and recurrence in adjuvant and metastatic settings. The objective of this article was to evaluate how these chemotherapeutic regimens affect the proportion of cancer stem cells and the expression of stemness markers.Method: We used the pancreatic adenocarcinoma cell line PANC-1 as a model to apply different chemotherapeutic protocols (monotherapy and combined therapy) using 5-Fluorouracil, Oxaliplatin, Irinotecan, Gemcitabine and Abraxane.Results: After analyzing different tumor stem cell markers (SOX2, OCT4, CD133, CD44 and CD24) in pancreatic cancer cells treated with different chemotherapeutic protocols by means of RT-qPCR, Oxaliplatin and Gemcitabine in monotherapy were the chemotherapies that selected the most cancer stem cells while the FOLFIRI protocol decreased them.Conclusions: Regarding the selection of markers, it has been much higher in the case of Gemcitabine alone. In conclusion, these findings could improve and personalize pancreatic cancer therapy.
Published: 2022

19. Factors associated with readmission to the Emergency Department in a cohort of COVID-19 hospitalized patients

Author: Antonio Cárdenas-Cruz, Pablo Redruello-Guerrero, Antonio Jesús Láinez-Ramos-Bossini, Mario Rivera-Izquierdo, Álvaro Romero-Duarte, [Romero-Duarte, Alvaro] Univ Granada, Fac Med, Granada 18016, Spain, [Redruello-Guerrero, Pablo] Univ Granada, Fac Med, Granada 18016, Spain, [Rivera-Izquierdo, Mario] Hosp Univ Clin San Cecilio, Serv Prevent Med & Publ Hlth, Granada 18016, Spain, [Rivera-Izquierdo, Mario] Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18016, Spain, [Rivera-Izquierdo, Mario] Inst Biosanitario Granada Ibs GRANADA, Granada 37007, Spain, [Jesus Lainez-Ramos-Bossini, Antonio] Virgen de las Nieves Univ Hosp, Dept Radiol, Granada 18016, Spain, [Jesus Lainez-Ramos-Bossini, Antonio] Univ Granada, PhD Programme Clin Med & Publ Hlth, Granada 18016, Spain, [Cardenas-Cruz, Antonio] Univ Granada, Dept Med, Granada 18016, Spain, [Cardenas-Cruz, Antonio] Hosp Poniente, Intens Care Unit, Almeria 04003, Spain, 'Artificial Intelligence for the diagnosis and prognosis of COVID-19' project - Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, Junta de Andalucia, and FEDER funds
Subjects: medicine.medical_specialty, Longitudinal study, Coronavirus disease 2019 (COVID-19), business.industry, Medical record, COVID-19, Emergency department, Logistic regression, medicine.disease_cause, Coronavirus, Hospitalization, Internal medicine, Superinfection, Cohort, Symptoms, Emergency, medicine, Observational study, business, Post-discharge
Abstract: This work was supported by the 'Artificial Intelligence for the diagnosis and prognosis of COVID-19' project (CV20-29480), funded by the Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, Junta de Andalucia, and the FEDER funds. We acknowledge the Faculty of Medicine, University of Granada, for the successful organization of the final degree projects, since this work was designed and conducted during the project of Alvaro Romero-Duarte. We also acknowledge all the healthcare workers from the Department of Preventive Medicine and Public Health, San Cecilio University Hospital for their restless commitment during the pandemic of COVID-19 and their continuous efforts for investigating and communicating their results to the scientific community. Finally, we thank the SEMERGEN-UGR Chair of Teaching and Research in Family Medicine for being an example of support and encouragement in Primary Care research., Introduction: The aim of this study was to describe the symptomatology and main factors associated with readmission to the Emergency Department (ED) in COVID-19 patients discharged from hospital during the first wave of the pandemic at the San Cecilio University Hospital, Granada, Spain. Methods: An observational longitudinal study was conducted in a cohort of 441 patients admitted to our hospital with confirmed SARS-CoV-2 polymerase chain reaction (PCR) from 1 March to 15 April 2020. Patients were followed up through medical records 6 months after discharge. Sociodemographic, clinical and symptomatologic variables were collected. Descriptive, bivariate and multivariate logistic regression analyses were performed. Results: The mean age of patients in the cohort was 66.4 years (s = 15.3), with 55.1% men. In-hospital mortality was 18.1%. The presence of persistent symptomatology was high (64.5%), especially respiratory (53.2%), systemic (46.3%) and neurological (31.0%). A total of 75 (20.8%) patients were readmitted to the ED during the 6 months following hospital discharge. The main factors associated with readmission to the ED were polymedication (P = 0.031), living in a care home (P = 0.014), fever (P = 0.047), general malaise (P < 0.001), thoracic pain (P < 0.001), headache (P = 0.012), hematological symptoms (P = 0.011), nephrological symptoms (P = 0.047), depressive symptoms (P = 0.009), syncope or hypotension (P = 0.006) and superinfection (P = 0.018). After multivariate adjustment analysis, thoracic pain (OR: 4.45, 95% CI: 1.88– 10.52), general malaise and hematological symptoms (OR: 3.95, 95% CI: 1.12–13.89) remained as risk factors. Conclusions: The presence of persistent symptomatology after hospital discharge in our cohort was common and varied. Polymedication and living in a care home made up the most vulnerable profile of COVID-19 patients for returning to the ED. Thoracic pain, general malaise and hematological symptoms were identified as potential markers of severity, along with others predictors. These findings might be useful for optimizing follow-up strategies. Future studies conducted in other geographical areas are necessary to corroborate our results., 'Artificial Intelligence for the diagnosis and prognosis of COVID-19' project - Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades CV20-29480, Junta de Andalucia European Commission
Published: 2022

20. Live well, die well – an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study

Author: Berivan Yildiz, Simon Allan, Misa Bakan, Pilar Barnestein-Fonseca, Michael Berger, Mark Boughey, Andri Christen, Gustavo G De Simone, Martina Egloff, John Ellershaw, Eline E C M Elsten, Steffen Eychmüller, Claudia Fischer, Carl Johan Fürst, Eric C T Geijteman, Gabriel Goldraij, Anne Goossensen, Svandis Iris Halfdanardottir, Dagny Faksvåg Haugen, Christel Hedman, Tanja Hoppe, Rosemary Hughes, Grethe Skorpen Iversen, Melanie Joshi, Hana Kodba-Ceh, Ida J Korfage, Urska Lunder, Nora Lüthi, Maria Luisa Martín-Roselló, Stephen Mason, Tamsin McGlinchey, Silvi Montilla, Birgit H Rasmussen, Inmaculada Ruiz-Torreras, Maria E C Schelin, Katrin Ruth Sigurdardottir, Valgerdur Sigurdardottir, Judit Simon, Ruthmarijke Smeding, Kjersti Solvåg, Julia Strupp, Vilma Tripodoro, Hugo M van der Kuy, Carin C D van der Rijt, Lia van Zuylen, Verónica I Veloso, Eva Vibora-Martin, Raymond Voltz, Sofia C Zambrano, Agnes van der Heide, Internal medicine, Public Health, Medical Oncology, Pharmacy, [Yildiz, Berivan] Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands, [Elsten, Eline E. C. M.] Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands, [Geijteman, Eric C. T.] Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands, [Korfage, Ida J.] Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands, [van der Heide, Agnes] Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands, [Allan, Simon] Arohanui Hosp, Palmerston North, New Zealand, [Bakan, Misa] Univ Clin Resp & Allerg Dis Golnik, Res Dept, Golnik, Slovenia, [Kodba-Ceh, Hana] Univ Clin Resp & Allerg Dis Golnik, Res Dept, Golnik, Slovenia, [Lunder, Urska] Univ Clin Resp & Allerg Dis Golnik, Res Dept, Golnik, Slovenia, [Barnestein-Fonseca, Pilar] CUDECA Hosp Fdn, CUDECA Inst Training & Res Palliat Care, Malaga, Spain, [Martin-Rosello, Maria Luisa] CUDECA Hosp Fdn, CUDECA Inst Training & Res Palliat Care, Malaga, Spain, [Ruiz-Torreras, Inmaculada] CUDECA Hosp Fdn, CUDECA Inst Training & Res Palliat Care, Malaga, Spain, [Vibora-Martin, Eva] CUDECA Hosp Fdn, CUDECA Inst Training & Res Palliat Care, Malaga, Spain, [Barnestein-Fonseca, Pilar] Ibima Inst, Grp C08 Pharma Econ Clin & Econ Evaluat Medicat &, Malaga, Spain, [Berger, Michael] Med Univ Vienna, Ctr Publ Hlth, Dept Hlth Econ, Vienna, Austria, [Fischer, Claudia] Med Univ Vienna, Ctr Publ Hlth, Dept Hlth Econ, Vienna, Austria, [Simon, Judith] Med Univ Vienna, Ctr Publ Hlth, Dept Hlth Econ, Vienna, Austria, [Boughey, Mark] St Vincents Hosp Melbourne, Dept Palliat Care, Fitzroy, Vic, Australia, [Christen, Andri] Univ Bern, Inselspital Univ Hosp Bern, Univ Ctr Palliat Care, Bern, Switzerland, [Egloff, Martina] Univ Bern, Inselspital Univ Hosp Bern, Univ Ctr Palliat Care, Bern, Switzerland, [Eychmuller, Steffen] Univ Bern, Inselspital Univ Hosp Bern, Univ Ctr Palliat Care, Bern, Switzerland, [Luthi, Nora] Univ Bern, Inselspital Univ Hosp Bern, Univ Ctr Palliat Care, Bern, Switzerland, [Zambrano, Sofia C.] Univ Bern, Inselspital Univ Hosp Bern, Univ Ctr Palliat Care, Bern, Switzerland, [De Simone, Gustavo G.] Inst Pallium Latinoamer, Res Network Red InPal, Buenos Aires, DF, Argentina, [Tripodoro, Vilma] Inst Pallium Latinoamer, Res Network Red InPal, Buenos Aires, DF, Argentina, [Ellershaw, John] Univ Liverpool, Inst Life Course & Med Sci, Palliat Care Unit, Liverpool, Merseyside, England, [Hughes, Rosemary] Univ Liverpool, Inst Life Course & Med Sci, Palliat Care Unit, Liverpool, Merseyside, England, [Mason, Stephen] Univ Liverpool, Inst Life Course & Med Sci, Palliat Care Unit, Liverpool, Merseyside, England, [McGlinchey, Tamsin] Univ Liverpool, Inst Life Course & Med Sci, Palliat Care Unit, Liverpool, Merseyside, England, [Smeding, Ruthmarijke] Univ Liverpool, Inst Life Course & Med Sci, Palliat Care Unit, Liverpool, Merseyside, England, [Elsten, Eline E. C. M.] Erasmus MC Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands, [Geijteman, Eric C. T.] Erasmus MC Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands, [van der Rijt, Carin C. D.] Erasmus MC Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands, [Furst, Carl Johan] Lund Univ, Inst Palliat Care, Lund, Sweden, [Hedman, Christel] Lund Univ, Inst Palliat Care, Lund, Sweden, [Rasmussen, Birgit H.] Lund Univ, Inst Palliat Care, Lund, Sweden, [Schelin, Maria E. C.] Lund Univ, Inst Palliat Care, Lund, Sweden, [Furst, Carl Johan] Lund Univ, Reg Skane, Lund, Sweden, [Hedman, Christel] Lund Univ, Reg Skane, Lund, Sweden, [Rasmussen, Birgit H.] Lund Univ, Reg Skane, Lund, Sweden, [Schelin, Maria E. C.] Lund Univ, Reg Skane, Lund, Sweden, [Furst, Carl Johan] Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden, [Hedman, Christel] Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden, [Schelin, Maria E. C.] Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden, [Goldraij, Gabriel] Hosp Privado Univ Cordoba, Internal Med Palliat Care Program, Cordoba, Argentina, [Goossensen, Anne] Univ Humanistic Studies, Informal Care & Care Eth, Utrecht, Netherlands, [Halfdanardottir, Svandis Iris] Landspitali Natl Univ Hosp, Palliat Care Unit, Reykjavik, Iceland, [Sigurdardottir, Valgerdur] Landspitali Natl Univ Hosp, Palliat Care Unit, Reykjavik, Iceland, [Haugen, Dagny Faksvag] Haukeland Hosp, Reg Ctr Excellence Palliat Care, Bergen, Norway, [Iversen, Grethe Skorpen] Haukeland Hosp, Reg Ctr Excellence Palliat Care, Bergen, Norway, [Sigurdardottir, Katrin Ruth] Haukeland Hosp, Reg Ctr Excellence Palliat Care, Bergen, Norway, [Solvag, Kjersti] Haukeland Hosp, Reg Ctr Excellence Palliat Care, Bergen, Norway, [Haugen, Dagny Faksvag] Univ Bergen, Dept Clin Med K1, Bergen, Norway, [Hedman, Christel] Stiftelsen Stockholms Sjukhem, Res Dept, Stockholm, Sweden, [Hoppe, Tanja] Univ Cologne, Fac Med, Dept Palliat Med, Cologne, Germany, [Joshi, Melanie] Univ Cologne, Fac Med, Dept Palliat Med, Cologne, Germany, [Strupp, Julia] Univ Cologne, Fac Med, Dept Palliat Med, Cologne, Germany, [Voltz, Raymond] Univ Cologne, Fac Med, Dept Palliat Med, Cologne, Germany, [Hoppe, Tanja] Univ Cologne, Univ Hosp, Cologne, Germany, [Joshi, Melanie] Univ Cologne, Univ Hosp, Cologne, Germany, [Strupp, Julia] Univ Cologne, Univ Hosp, Cologne, Germany, [Voltz, Raymond] Univ Cologne, Univ Hosp, Cologne, Germany, [Martin-Rosello, Maria Luisa] IBIMA Inst, Grp CA15 Palliat Care, Malaga, Spain, [Ruiz-Torreras, Inmaculada] IBIMA Inst, Grp CA15 Palliat Care, Malaga, Spain, [Montilla, Silvi] Univ Buenos Aires, Inst Med Res A Lanari, Buenos Aires, DF, Argentina, [Tripodoro, Vilma] Univ Buenos Aires, Inst Med Res A Lanari, Buenos Aires, DF, Argentina, [Veloso, Veronica, I] Univ Buenos Aires, Inst Med Res A Lanari, Buenos Aires, DF, Argentina, [Sigurdardottir, Katrin Ruth] Haukeland Hosp, Dept Anaesthesia & Surg Serv, Specialist Palliat Care Team, Bergen, Norway, [van der Kuy, Hugo M.] Univ Med Ctr, Dept Clin Pharm, Erasmus MC, Rotterdam, Netherlands, [van Zuylen, Lia] Univ Amsterdam, Dept Med Oncol, Med Ctr, Amsterdam, Netherlands, [Voltz, Raymond] Univ Cologne, Fac Med, Ctr Integrated Oncol Aachen Bonn Cologne Dusseldo, Cologne, Germany, [Voltz, Raymond] Univ Cologne, Fac Med, Clin Trials Ctr ZKS, Cologne, Germany, [Voltz, Raymond] Univ Cologne, Fac Med, Ctr Hlth Serv Res ZVFK, Cologne, Germany, [Zambrano, Sofia C.] Univ Bern, Inst Social & Prevent Med ISPM, Bern, Switzerland, European Union, University of Humanistic Studies, A meaningful life in a just and caring society, and General Practice
Subjects: palliative care, Terminally-ill, Questionnaire, public health, 610 Medicine & health, General Medicine, adult palliative care, SDG 3 - Good Health and Well-being, Cancer-patients, 360 Social problems & social services, End, Perspective, Validation, Perceptions, Quality-of-life, Adaptation
Abstract: IntroductionAdequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of terminally ill patients and their families.Methods and analysisThe iLIVE study is an international cohort study in which patients with an estimated life expectancy of 6 months or less are followed up until they die. In total, 2200 patients will be included in 11 countries, that is, 200 per country. In addition, one relative per patient is invited to participate. All participants will be asked to fill in a questionnaire, at baseline and after 4 weeks. If a patient dies within 6 months of follow-up, the relative will be asked to fill in a post-bereavement questionnaire. Healthcare use in the last week of life will be evaluated as well; healthcare staff who attended the patient will be asked to fill in a brief questionnaire to evaluate the care that was provided. Qualitative interviews will be conducted with patients, relatives and healthcare professionals in all countries to gain more in-depth insights.Ethics and disseminationThe cohort study has been approved by ethics committees and the institutional review boards (IRBs) of participating institutes in all countries. Results will be disseminated through the project website, publications in scientific journals and at conferences. Within the project, there will be a working group focusing on enhancing the engagement of the community at large with the reality of death and dying.Trial registration numberNCT04271085.
Published: 2022

21. Beetroot Juice Produces Changes in Heart Rate Variability and Reduces Internal Load during Resistance Training in Men: A Randomized Double-Blind Crossover

Author: Jose Manuel Jurado-Castro, David Casanova-Rodriguez, Julian Campos-Perez, Francisco Jesus Llorente-Cantarero, Candelaria Alonso De La Florida-Villagran, Víctor Manuel Diaz-Bernier, Antonio Ranchal-Sanchez, [Jurado-Castro, Jose Manuel] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIB, Metab & Invest Unit, Cordoba 14004, Spain, [Jurado-Castro, Jose Manuel] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain, [Llorente-Cantarero, Francisco Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain, [Jurado-Castro, Jose Manuel] Univ Seville, Escuela Univ Osuna, Ciencias Act Fis & Deporte, Osuna 41640, Spain, [Casanova-Rodriguez, David] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba 14071, Spain, [De La Florida-Villagran, Candelaria Alonso] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba 14071, Spain, [Diaz-Bernier, Victor Manuel] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba 14071, Spain, [Ranchal-Sanchez, Antonio] Univ Cordoba, Fac Med & Nursing, Dept Nursing Pharmacol & Physiotherapy, Cordoba 14071, Spain, [Campos-Perez, Julian] Univ Cordoba, Dept Food Sci & Technol, Campus Univ Rabanales, Cordoba 14004, Spain, [Llorente-Cantarero, Francisco Jesus] Univ Cordoba, Fac Educ, Dept Specif Didact, Cordoba 14004, Spain, [Ranchal-Sanchez, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIB, Grp Invest Clin Epidemiol Atenc Primaria, Cordoba 14004, Spain, and Departamento de Enfermeria, Farmacologia y Fisioterapia (Facultad de Medicina y Enfermeria, Universidad de Cordoba)
Subjects: Dietary nitrate supplementation, Nutrition and Dietetics, heartbeat, heart rate control, dietary supplement, nitric oxide, autonomic nervous system, beta vulgaris, Parasympathetic reactivation, Cardiovascular health, Nitric-oxide, Anaerobic exercise, Oxidative stress, Inorganic nitrate, Blood-pressure, Aerobic exercise, Potential benefits, Food Science
Abstract: Beetroot juice (BJ) has been used as a sport supplement, improving performance in resistance training (RT). However, its effect on the modulation of the autonomic nervous system has not yet been widely studied. Therefore, the objective of this randomized double-blind crossover study was to assess the effect of acute BJ supplementation compared to placebo in blood pressure (BP), heart rate (HR), heart rate variability (HRV) and internal load during RT measure as Root Mean Square of the Successive Differences between adjacent RR intervals Slope (RMSSD and RMSSD-Slope, respectively). Eleven men performed an incremental RT test (three sets at 60%, 70% and 80% of their repetition maximum) composed by back squat and bench press with. HR, HRV and RMSSD-Slope were measured during and post exercise. As the main results, RMSSD during exercise decrease in the BJ group compared to placebo (p = 0.023; ES = 0.999), there were no differences in RMSSD post-exercise, and there were differences in RMSSD-Slope between groups in favor of the BJ group (p = 0.025; ES = 1.104) with a lower internal load. In conclusion, BJ supplementation seems to be a valuable tool for the reduction in the internal load of exercise during RT measured as RMSSD-Slope while enhancing performance.
Published: 2022

22. The Teaching of Surface Anatomy by Body Painting

Author: Gonzalo Perez-Arana, Antonio Ribelles-García, David Almorza-Gomar, J Arturo Prada-Oliveira, Carmen Carrasco-Molinillo, [Carrasco-Molinillo, Carmen] Univ Cadiz, Fac Med, Dept Human Anat & Embryol, Plaza Fragela 9, Cadiz 11003, Spain, [Ribelles-Garcia, Antonio] Univ Cadiz, Fac Med, Dept Human Anat & Embryol, Plaza Fragela 9, Cadiz 11003, Spain, [Arturo Prada-Oliveira, J.] Univ Cadiz, Fac Med, Dept Human Anat & Embryol, Plaza Fragela 9, Cadiz 11003, Spain, [Perez-Arana, Gonzalo] Hosp Puerta Mar, INUBICA Biomed Inst Invest, Avda Ana de Viya 21, Cadiz 11009, Spain, [Almorza Gomar, David] Univ Cadiz, Dept Operat Stat & Res, Cadiz, Spain, Anatomía Patológica, Biología Celular, Histología, Historia de la Ciencia, Medicina Legal..., and Estadística e Investigación Operativa
Subjects: Gross-anatomy, Medical education, Body painting, Experiences, education, Learning teaching, Medical practice, Clinical anatomy, Satisfaction questionnaire, Anatomical knowledge, Tool, Anatomy teaching, Surface anatomy, Anatomy, Psychology
Abstract: SUMMARY: The present project on learning surface anatomy through the body painting method was undertaken because anatomical knowledge supports medical practice. The appropriate anatomical training of the doctor depends on surface anatomy. We considered the renovation of teaching strategies and didactic resources to optimize the overall teaching- learning process. 189 first-year medical students, enrolled in the Trunk and Splanchnology course at the University of Cádiz (Spain) participated in this study. Students were divided into 5 groups each of 38-41 students. The students were asked to complete a satisfaction questionnaire supplied to each participant through an on-line platform. On the basis of the results, we recommend the body painting method as an alternative tool for learning surface and clinical anatomy.
Published: 2019

23. Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice

Author: Mehmet Ozansoy, Rumeyza Kazancioglu, Ulkan Kilic, Arzu Şakul, Yasemin Yozgat, Şule Ayla, Kazim Sahin, Birsen Elibol, Mehmet Yalçın Günal, Huveyda Basaga, ALKÜ, 0-belirlenecek, ELİBOL, BİRSEN, Sakul, Arzu Istanbul Medipol Univ, Sch Med, Dept Med Pharmacol, Istanbul, Turkey, Ozansoy, Mehmet Istanbul Medipol Univ, Sch Med, Dept Physiol, Istanbul, Turkey, Elibol, Birsen Bezmialem Vakif Univ, Fac Med, Dept Med Biol, Istanbul, Turkey, Ayla, Sule Istanbul Medipol Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey, Gunal, Mehmet Yalcin Alanya Alaaddin Keykubat Univ, Dept Physiol, Sch Med, Antalya, Turkey, Yozgat, Yasemin Istanbul Medipol Univ, Regenerat & Restorat Med Res Ctr REMER, Istanbul, Turkey, Basaga, Huveyda Sabanci Univ, Fac Engn & Nat Sci, Biol Sci & Bioengn Program, Istanbul, Turkey, Sahin, Kazim Firat Univ, Fac Vet Med, Dept Anim Nutr, Elazig, Turkey, Kazancioglu, Rumeyza Bezmialem Vakif Univ, Fac Med, Dept Nephrol, Istanbul, Turkey, Kilic, Ulkan Univ Hlth Sci, Fac Med, Dept Med Biol, Istanbul, Turkey, gunal, mehmet yalcin -- 0000-0001-7702-2441, and Sahin, Kazim -- 0000-0001-9542-5244
Subjects: cisplatin-induced nephrotoxicity, mice, Physiology, 0206 medical engineering, 02 engineering and technology, Biology, Pharmacology, squalene, medicine.disease_cause, Microbiology, Article, Nephrotoxicity, Proinflammatory cytokine, 03 medical and health sciences, Squalene, chemistry.chemical_compound, 0302 clinical medicine, Genetics, medicine, oxidative-stress, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cisplatin, Kidney, AKT, Cell Biology, Sakul A., Ozansoy M., ELİBOL B., Ayla S., Gunal M. Y. , Yozgat Y., Basaga H., Sahin K., KAZANCIOĞLU R., Kilic U., -Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice-, TURKISH JOURNAL OF BIOLOGY, cilt.43, ss.179-188, 2019, 020601 biomedical engineering, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, mTOR, General Agricultural and Biological Sciences, Oxidative stress, Biyoloji, medicine.drug
Abstract: WOS: 000471268100003 The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity, we investigated the molecular effects of squalene against cisplatin-induced oxidative stress and kidney damage in mice. Single dose of cisplatin (7 mg/kg) was given to male Balb/c mice. Squalene (100 mg/kg/day) was administered orogastrically to mice for 10 days. Following sacrification, molecular alterations were investigated as analysis of the levels of oxidative stress index (OSI), inflammatory cytokines and cell survival-related proteins in addition to histopathological examinations in mice kidney tissue. The level OSI and Interferon-gamma (IFN-gamma) decreased in the cisplatin and squalene cotreated mice compared to cisplatin-treated mice. Squalene treatment also increased the activation of protein kinase B (AKT). Furthermore, cisplatin-induced inactivation of mammalian target of rapamycin (mTOR) and histopathological damages were reversed by squalene. It may be suggested that squalene ameliorated the cisplatin-induced histopathological damages in the kidney through activation of AKT/mTOR signaling pathway by regulating the balance of the redox system due to its antioxidative effect.
Published: 2019

24. Female gender specific association of the Reelin (RELN) gene rs7341475 variant with schizophrenia

Author: Ali Sazci, Mavi Deniz Sozuguzel, Mustafa Yildiz, Sozuguzel, Mavi Deniz Istanbul Medipol Univ, Int Sch Med, Dept Med Biol, Istanbul, Turkey, Sazci, Ali Kocaeli Univ, Fac Med, Dept Med Biol & Genet, TR-41380 Kocaeli, Turkey, and Yildiz, Mustafa Kocaeli Univ, Dept Psychiat, Fac Med, Kocaeli, Turkey
Subjects: Adult, Male, 0301 basic medicine, Turkish population, Adolescent, Genotype, Turkey, Cell Adhesion Molecules, Neuronal, Population, Nerve Tissue Proteins, rs7341475, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Gene Frequency, Risk Factors, Polymorphism (computer science), Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, Allele, education, Turkish Population, Molecular Biology, Allele frequency, Alleles, Genetic Association Studies, Aged, Extracellular Matrix Proteins, education.field_of_study, Serine Endopeptidases, Rs7341475, Female Gender, General Medicine, Middle Aged, Genotype frequency, Reelin Protein, 030104 developmental biology, Case-Control Studies, Specific Association, 030220 oncology & carcinogenesis, Schizophrenia, Female, RELN Gene
Abstract: WOS: 000470332600078 PubMed ID: 30980267 RELN gene encodes a large extracellular matrix protein which is critical for neuronal migration, cell positioning and cell-cell interactions. It also controls the synaptic plasticity of neurons for initiation and maintenance of long term potentiation. The aim of this study is to investigate the association of RELN rs7341475 variant with schizophrenia. Genomic DNA isolation was performed from 105 schizophrenic patients and 137 healthy controls to determine RELN rs7341475 genotypes. Genotype and allele frequencies were determined by a polymerase chain reaction-restriction fragment length polymorphism method developed in our laboratory. Statistical analysis was performed using (2) test. The frequencies for G allele were 79.5% in cases and 81.0% in controls, for A allele 20.5% in cases and 19.0% in controls in the overall population. The genotype frequencies of the RELN gene rs7341475 variant were GG; 63.8%, GA; 31.4% and AA; 4.8% in cases, GG; 63.5%, GA; 35.0% and AA; 1.5% in controls in the overall population. There was no statistically significant association between the rs7341475 variant of RELN gene and schizophrenia in the overall population ((2)=2.473, p=0.290). In the gender specific analysis, female gender specific association was only found. The RELN rs7341475 variant GG genotype was significantly associated with schizophrenia (p=0.034, OR 2.760, 95% CI 1.058-7.197) and A allele was protective against schizophrenia (p=0.034, OR 0.362, 95% CI 0.139-0.945). All cases and controls were in Hardy-Weinberg equilibrium (p>0.05). Population size can be increased to improve the statistical power. Moreover, other RELN gene variants which are especially involved in neuronal migration and epigenetic regulation may be analyzed for revealing the complex genetic architecture of schizophrenia. In conclusion, there was only association between the RELN rs7341475 variant and schizophrenia in the female gender in a Turkish population. Kocaeli University [2011/68] This study was supported by Kocaeli University, Project No: 2011/68 to AS.
Published: 2019

25. Effects of post-learning REM sleep deprivation on hippocampal plasticity-related genes and microRNA in mice

Author: Ruslan Bayramov, Kamile Yazgan, Sebahattin Karabulut, Ahmet Sevki Taskiran, Fadime Ozdemir, Tugba Topaloglu, Asuman Gölgeli, Keziban Korkmaz Bayramov, Ergül Ergen, [Karabulut, Sebahattin -- Yazgan, Kamile -- Golgeli, Asuman] Erciyes Univ, Fac Med, Dept Med Physiol, Kayseri, Turkey -- [Bayramov, Keziban Korkmaz -- Bayramov, Ruslan -- Topaloglu, Tugba -- Ergen, Ergul] Erciyes Univ, Fac Med, Dept Med Genet, Kayseri, Turkey -- [Bayramov, Keziban Korkmaz] Erciyes Univ, Genome & Stem Cell Ctr, Kayseri, Turkey -- [Ozdemir, Fadime] Erciyes Univ, Vet Med, Dept Vet Genet, Kayseri, Turkey -- [Taskiran, Ahmet Sevki] Cumhuriyet Univ, Fac Med, Dept Med Physiol, Sivas, Turkey, Bayramov, Ruslan -- 0000-0002-3682-2140, and KORKMAZ BAYRAM, KEZIBAN -- 0000-0002-1228-1298
Subjects: Male, Sleep, REM, Hippocampus, Morris water navigation task, Biology, Hippocampal formation, CREB, Mice, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Memory, Ca2+/calmodulin-dependent protein kinase, medicine, Animals, Learning, Cyclic AMP Response Element-Binding Protein, Maze Learning, Memory Consolidation, 030304 developmental biology, REM sleep deprivation, Mice, Inbred BALB C, 0303 health sciences, Neuronal Plasticity, microRNA, Brain-Derived Neurotrophic Factor, Sleep in non-human animals, MicroRNAs, Sleep deprivation, biology.protein, Sleep Deprivation, Memory consolidation, medicine.symptom, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Sleep, Morris water maze, Neuroscience, psychological phenomena and processes, 030217 neurology & neurosurgery
Abstract: WOS: 000458707500002, PubMed ID: 30594545, Sleep is essential for memory consolidation that stabilizes a memory trace. Memory consolidation includes waves of new gene expression and protein synthesis. Recently, microRNAs (miRNAs) have emerged as critical regulators of memory processes. Previous studies demonstrated that rapid eye movement (REM) sleep deprivation (REM SD) during specific time windows after training in the Morris water maze (MWM) task impairs memory consolidation. Here, we showed that the post-learning REM sleep, extending from 3 to 6 h after last training, is critical for spatial learning in the MWM task. Further, we found that the REM SD after training significantly changes the hippocampal expression of brain-derived neurotrophic factor (BDNF) mRNA; however, it causes minimal difference in the hippocampal expressions of calcium-calmodulin-dependent protein kinase II (CAMKII) and cAMP response-element-binding (CREB). In addition, it considerably affected the hippocampal expressions of miR-132, miR-182, and miR-124. In conclusion, after the MWM task, the post-learning REM sleep during specific time windows can modulate spatial memory consolidation, and its deprivation can impact the hippocampal transcriptional processes including memory-related miRNAs and mRNAs., Division of Scientific Research Projects in Erciyes University, Kayseri, Turkey [TDK-2015-6077], This work was supported by the Division of Scientific Research Projects in Erciyes University, Kayseri, Turkey under Grant TDK-2015-6077.
Published: 2019

26. The Relationship of Exercise Capacity with Fat-Free Mass and Body Mass Index in Elderly Patients with Chronic Obstructive Pulmonary Disease

Author: Yeltekin Demirel, Sulhattin Arslan, Ayşe Çinar, and [Cinar, Ayse -- Demirel, Yeltekin] Cumhuriyet Univ, Fac Med, Dept Family Med, Sivas, Turkey -- [Arslan, Sulhattin] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey
Subjects: Chronic Obstructive, medicine.medical_specialty, business.industry, Pulmonary disease, Exercise capacity, Pulmonary Disease, Fat free mass, Internal medicine, medicine, Cardiology, Geriatrics and Gerontology, business, Exercise, Body mass index
Abstract: WOS: 000462045500010, Introduction: Skeletal muscle weakness is a major systemic manifestation of chronic obstructive pulmonary disease (COPD). Loss of muscle mass contributes to impaired exercise capacity and peripheral muscle weakness and manifests as reduced fat-free mass in patients with COPD. This study aimed to examine the effects of fat-free mass, body mass index and airway obstruction severity on exercise capacity. Materials and Method: This study included 70 patients with COPD and 70 healthy individuals. Patients with COPD were divided into two groups: non-severe (GOLD Stage 1,2) and severe (GOLD Stage 2,3). Body mass index, fat-free mass, fat mass and percentage fat mass were measured, and pulmonary function tests were performed for all participants. The sixminute walk test was used as an index of exercise capacity. The Student's t-test, chi-square test and Pearson's correlation coefficient were used to compare study parameters. Results: The average fat mass, percentage fat mass and six-minute walk test were reduced in the COPD cohort. No significant correlations were found between the six-minute walk test and body mass index, fat-free mass, fat mass and percentage fat mass. A significant correlation was found between the six-minute walk test and forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC in patients with non-severe COPD. Conclusion: Exercise capacity is significantly reduced in patients with COPD.The significant relationship between the six-minute walk test score and pulmonary function test variables indicates that disease-related obstruction affects exercise capacity.
Published: 2019

27. Durable remissions in TCF3-HLF positive acute lymphoblastic leukemia with blinatumomab and stem cell transplantation

Author: Volkan Hazar, Sema Anak, Brice Mouttet, Sarah Elitzur, Jean-Pierre Bourquin, Martin Schrappe, Benoit Brethon, Luciana Vinti, Jerry Stein, Martin Stanulla, Philip Ancliff, Yöntem Yaman, Ajay Vora, Anja Möricke, Joachim B. Kunz, Christiane Chen-Santel, Nicole Bodmer, Gunnar Cario, Franco Locatelli, Arend von Stackelberg, André Baruche, Mouttet, Brice, Bodmer, Nicole, Bourquin, Jean-Pierre Univ Childrens Hosp Zurich, Pediat Oncol, Zurich, Switzerland, Vinti, Luciana, Locatelli, Franco Sapienza Univ Rome, IRCCS Osped Bambino Gesu, Dept Pediat Haematooncol, Rome, Italy, Ancliff, Philip, Vora, Ajay Great Ormond St Hosp Sick Children, Haematol & Oncol Dept, London, England, Brethon, Benoit, Baruchel, Andre Hop Robert Debre, AP HP, Dept Pediat Hematol, Paris, France, Cario, Gunnar, Moericke, Anja, Schrappe, Martin Christian Albrechts Univ Kiel, ALL BFM Study Grp, Dept Pediat 1, Kiel, Germany, Schrappe, Martin Univ Med Ctr Schleswig Holstein, Kiel, Germany, Chen-Santel, Christiane, von Stackelberg, Arend Charite, Dept Pediat Oncol Hematol, Berlin, Germany, Elitzur, Sarah Tel Aviv Univ, Sackler Fac Med, Schneider Childrens Med Ctr, Pediat Hematol Oncol, Tel Aviv, Israel, Hazar, Volkan, Yaman, Yontem, Anak, Sema Medipol Univ Hosp, Dept Pediat Hematol, Istanbul, Turkey, Kunz, Joachim Heidelberg Univ, Pediat Oncol Hematol & Immunol, Heidelberg, Germany, Stein, Jerry Tel Aviv Univ, Sackler Fac Med, Schneider Childrens Med Ctr, Bone Marrow Transplant Unit, Tel Aviv, Israel, Schrappe, Martin Christian Albrechts Univ Kiel, Univ Med Ctr, Pediat, Kiel, Germany, Stanulla, Martin Hannover Med Sch, Pediat Hematol & Oncol, Hannover, Germany, University of Zurich, and Bourquin, Jean-Pierre
Subjects: Oncogene Proteins, Fusion, Oncogene Proteins, 2720 Hematology, 610 Medicine & health, EDDY, Antineoplastic Agents, Immunological, Text mining, immune system diseases, hemic and lymphatic diseases, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Antibodies, Bispecific, medicine, Homologous chromosome, Humans, Transplantation, Homologous, Combined Modality Therapy, Online Only Articles, Mandibular Molar, business.industry, Hematopoietic Stem Cell Transplantation, Consolidation Chemotherapy, Hematology, Transplantation, Treatment Outcome, 10036 Medical Clinic, Smear Layer, Cancer research, Blinatumomab, Debris, Stem cell, business, Root Canal Preparation, medicine.drug
Abstract: WOS: 000469839300005 PubMed ID: 30765470 TCF3-HLF-positive leukemia represents a rare subtypeof childhood acute lymphoblastic leukemia (ALL), characterized by a high rate of treatment failure despite treatment intensification and allogeneic stem cell transplantation (SCT). Given the high and homogeneous expressionof CD19 on blast cells of this leukemia subtype, thesepatients may benefit from CD19-directed immunotherapy. Here, we report the experience on nineTCF3-HLF-positive ALL patients, most of whom weretreated early in first consolidation with blinatumomab asa bridge to SCT between 2015 and 2018. Treatment withblinatumomab was generally well tolerated; reversibleneurotoxicity was observed in two patients. All ninepatients achieved molecular remission after blinatumomab treatment; seven underwent SCT and for onepatient SCT is planned. Median follow up after start ofblinatumomab treatment was 342 days, and four patientsremain in molecular remission after a follow up of 1317,1292, 1245, and 342 days, respectively. Three patientsdied because of infectious complications not directlyrelated to blinatumomab, because they occurred eitherafter SCT or after emergence of a CD19-negativeleukemia clone. In the light of these encouraging observations, CD19-directed immunotherapy should be considered early after induction chemotherapy inTCF3-HLF-positive ALL children and patients’ outcomemonitored systematically by study groups.
Published: 2019

28. Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease

Author: Bülent Özdemir, Sulhattin Arslan, Levent Özdemir, Gürsel Yildiz, Erdal Kaysoydu, and [Arslan, Sulhattin -- Kaysoydu, Erdal] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey -- [Yildiz, Gursel] Okan Univ, Div Nephrol, Dept Internal Med, Fac Med, Aydinli Yolu Cad,Aydemir Sk 2, TR-34947 Istanbul, Turkey -- [Ozdemir, Levent] Cumhuriyet Univ, Fac Med, Dept Publ Hlth, Sivas, Turkey -- [Ozdemir, Bulent] Uludag Univ, Fac Med, Dept Cardiol, Bursa, Turkey
Subjects: Male, Spirometry, Pulmonology, media_common.quotation_subject, Pulmonary disease, Context (language use), 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Forced Expiratory Volume, Economic history, medicine, Humans, Hypoxia, Aged, media_common, Inflammation, medicine.diagnostic_test, chronic obstructive, business.industry, hypoxia, Empire, blood pressure, Islam, Carbon Dioxide, Hydrogen-Ion Concentration, Middle Aged, respiratory tract diseases, Oxygen, Bicarbonates, C-Reactive Protein, Blood pressure, inflammation, Case-Control Studies, Islamization, Medicine, Original Article, Female, 030211 gastroenterology & hepatology, pulmonary disease, chronic obstructive, Inflammation Mediators, Apostasy, business
Abstract: WOS: 000454539700011, PubMed ID: 30428648, Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively. Nearly 25% of patients with COPD die due to cardiovascular diseases. In this study, we aimed to evaluate the relationship between the blood pressure, inflammation, hypoxia, hypercapnia, and the severity of airway obstruction. Methods: We included 75 COPD patients in the study with 45 control cases. We evaluated age, sex, body mass index, smoking history, C-reactive protein levels, 24-hour ambulatory blood pressure Holter monitoring, arterial blood gas, and respiratory function tests of the patient and the control groups. Results: In COPD patients, the night time systolic, diastolic blood pressures and pulse per minute and the mean blood pressures readings were significantly elevated compared to the control group (p < 0.05). In the correlation analysis, night time systolic pressure was associated with all the parameters except forced expiratory volume in 1 second (FEV1%). Diastolic blood pressure was associated with pH and HCO3 levels. The mean night time, day time pulse pressures and 24-hour pulse per minute values were also associated with all the parameters except FEV1%. Conclusions: In this study we found that parameters of systolic and diastolic blood pressures and pulse pressures were significantly elevated in COPD patients compared to the control groups. Blood pressure was associated blood gas parameters and inflammation parameters in COPD patients. This, in turn, may cause understanding of the pathophysiology of COPD and its complications.
Published: 2019

29. A Misleading Parameter in the Diagnosis of Chronic Hepatitis B: Persistently Normal Transaminases

Author: Mehmet Bayram, Engin Altinkaya, Serkan Yaraş, Ali Riza Koksal, Canan Alkim, Banu Yılmaz Özgüven, Osman Özdoğan, [Ozdogan, Osman -- Yaras, Serkan] Mersin Univ, Fac Med, Dept Gastroenterol, Mersin, Turkey -- [Koksal, Ali Riza -- Bayram, Mehmet -- Alkim, Canan] Sisli Hamidiye Etfal Training & Res Hosp, Clin Gastroenterol, Istanbul, Turkey -- [Altinkaya, Engin] Cumhuriyet Univ, Fac Med, Dept Gastroenterol, Sivas, Turkey -- [Yilmaz Ozguven, Banu] Sisli Hamidiye Etfal Training & Res Hosp, Clin Pathol, Istanbul, Turkey, and Koksal, Ali Riza -- 0000-0002-5693-5951
Subjects: lcsh:Internal medicine, medicine.medical_specialty, business.industry, hepatitis B e antigen-negative chronic hepatitis, hepatitis B e antigennegative chronic hepatitis, lcsh:R, inactive hepatitis B virus carrier, lcsh:Medicine, Hepatitis B, Gastroenterology, digestive system diseases, lcsh:Infectious and parasitic diseases, Chronic hepatitis, Internal medicine, Medicine, hepatitis B virus DNA, lcsh:RC109-216, lcsh:RC31-1245, business
Abstract: WOS: 000454450900005, Objectives: Most of the patients with hepatitis B e (HBe)-negative hepatitis B have persistently normal transaminases (PNALT) levels. Patients, who have higher fibrosis and necroinflammatory activity scores, are at high risk for hepatocellular carcinoma and cirrhosis. Therefore, it is important to distinguish between active and inactive hepatitis in this group. Materials and Methods: Sixty-six treatment-naive, non-cirrotic, HBe antigen (HBeAg)-negative and a PNALT and a level of a hepatitis B virus (HBV) DNA level of >= 2000 IU/mL were included in this study. lshak's scoring system was used for histopathological evaluation. Chronic hepatitis was defined as a fibrosis score of higher than/equal to 2 and/or a histological activity index score of higher than 4. Results: The percentage of patients diagnosed with advanced fibrosis score and high necroinflammatory activity was 65% and 48%, respectively. Accordingly, 76% of patients were considered to have chronic hepatitis. Level of the HBV DNA was the most significant value for predicting chronic hepatitis. 94.1% of patients with a HBV DNA value over 20000 IU/mL had chronic hepatitis (p
Published: 2018

30. Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia

Author: Ertugrul Kilic, Ulkan Kilic, Burak Yulug, Gulsen Babacan Yildiz, Arzu Şakul, Birsen Elibol, Omer Uysal, Kilic, Ulkan Univ Hlth Sci, Fac Med, Dept Med Biol, Tibbiye Cad 38, TR-34668 Istanbul, Turkey, Elibol, Birsen Bezmialem Vakif Univ, Fac Med, Dept Med Biol, Istanbul, Turkey, Uysal, Omer Bezmialem Vakif Univ, Fac Med, Dept Biostat, Istanbul, Turkey, Kilic, Ertugrul Istanbul Medipol Univ, Fac Med, Dept Med Physiol, Istanbul, Turkey, Yulug, Burak Istanbul Medipol Univ, Fac Med, Dept Neurol, Istanbul, Turkey, Sakul, Arzu Sayin Istanbul Medipol Univ, Fac Med, Dept Med Pharmacol, Istanbul, Turkey, Yildiz, Gulsen Babacan Bezmialem Vakif Univ, Fac Med, Dept Neurol, TR-34093 Istanbul, Turkey, Yulug, Burak Alanya Alaaddin Keykubat Univ, Fac Med, Dept Neurol, Alanya, Turkey, Kilic, Ertugrul -- 0000-0001-6494-8923, ALKÜ, 0-belirlenecek, and ELİBOL, BİRSEN
Subjects: Male, 0301 basic medicine, Oncology, Aging, medicine.medical_specialty, Single-nucleotide polymorphism, Inflammation, Disease, Logistic regression, medicine.disease_cause, Polymorphism, Single Nucleotide, Biochemistry, Epigenesis, Genetic, 03 medical and health sciences, Endocrinology, Sirtuin 1, Alzheimer Disease, Internal medicine, Genetics, medicine, Humans, Dementia, TLR4, Molecular Biology, Aged, Aged, 80 and over, IL-7, kılıç U., Elibol B., Uysal O., Kilic E., Yulug B., Sakul A. S. , Yildiz G. B. , -Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia-, EXPERIMENTAL GERONTOLOGY, cilt.111, ss.203-209, 2018, business.industry, Interleukin-7, SIRT1 polymorphism, Neurodegeneration, Cell Biology, Middle Aged, Alzheimer's disease, medicine.disease, Toll-Like Receptor 4, Logistic Models, 030104 developmental biology, Oxidative stress, Case-Control Studies, Female, medicine.symptom, business, Biomarkers
Abstract: Uysal, Omer/0000-0002-8833-697X; Kilic, Ertugrul/0000-0001-6494-8923; Elibol, Birsen/0000-0002-9462-0862 WOS: 000443177600024 PubMed: 30071285 Sirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate interactions of sirtuins with inflammatory markers in neurodegenerative diseases. We analyzed SIRT1's association with chronic inflammation in dementia as an age-related neurodegenerative condition through Toll-like receptor 4 (TLR4) and interleukin-7 (IL7) for the first time. In the present study, we observed a significant increase in the level of SIRT1 in patients with all types of dementia. Interestingly, the level of TLR4 protein was significantly lower in only the patients with Alzheimer's disease (AD) compared to the healthy elderly subjects. There was no significant change in the level of IL7 between the diseased and healthy elderly subjects. A significant positive correlation between SIRT1 level and age in healthy elderly subjects was evident according to Pearson's correlation test. However, this correlation was not observed in the dementia patients. Furthermore, the positive correlation between the levels of IL7 and TLR4 in the healthy elderly subjects was absent in the dementia patients. However, there was no direct association between the examined single nucleotide polymorphisms (SNPs) and dementia at the molecular level. According to logistic regression analysis, dementia risk increases 1.16 times due to an increase in the SIRT1 level and 24.23 times due to a decrease in the TLR4 level. Interestingly, a high level in the total antioxidant status (TAS) increases the risk of dementia approximately 33.32 times. Therefore, the current study, for the first time, provides a much better molecular understanding of the interaction between decreasing TLR4 levels and increasing SIRT1 levels in dementia, especially in AD. Furthermore, it highlights the importance of epigenetics in several age-related diseases and suggests that developing novel therapies to prevent or slow down the progression of dementia may support healthy aging.
Published: 2018

31. Anemonia sulcata and Its Symbiont Symbiodinium as a Source of Anti-Tumor and Anti-Oxidant Compounds for Colon Cancer Therapy: A Preliminary In Vitro Study

Author: Milagros Galisteo, Cristina Mesas, Mercedes Peña, Gloria Perazzoli, Jose Prados, Rosario Martínez, Jesús M. Porres, Laura Cabeza, Consolación Melguizo, [Cabeza, Laura] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Pena, Mercedes] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Mesas, Cristina] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Perazzoli, Gloria] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Prados, Jose] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Melguizo, Consolacion] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain, [Cabeza, Laura] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Pena, Mercedes] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Mesas, Cristina] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Perazzoli, Gloria] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Prados, Jose] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Melguizo, Consolacion] Univ Granada, Dept Anat & Embryol, Fac Med, Granada 18071, Spain, [Cabeza, Laura] SAS Univ Granada, Biosanitary Inst Granada Ibs Granada, Granada 18014, Spain, [Pena, Mercedes] SAS Univ Granada, Biosanitary Inst Granada Ibs Granada, Granada 18014, Spain, [Mesas, Cristina] SAS Univ Granada, Biosanitary Inst Granada Ibs Granada, Granada 18014, Spain, [Perazzoli, Gloria] SAS Univ Granada, Biosanitary Inst Granada Ibs Granada, Granada 18014, Spain, [Prados, Jose] SAS Univ Granada, Biosanitary Inst Granada Ibs Granada, Granada 18014, Spain, [Melguizo, Consolacion] SAS Univ Granada, Biosanitary Inst Granada Ibs Granada, Granada 18014, Spain, [Martinez, Rosario] Univ Granada, Inst Nutr & Food Technol INyTA, Biomed Res Ctr CIBM, Dept Physiol, Granada 18100, Spain, [Porres, Jesus M.] Univ Granada, Inst Nutr & Food Technol INyTA, Biomed Res Ctr CIBM, Dept Physiol, Granada 18100, Spain, [Galisteo, Milagros] Univ Granada, Sch Pharm, Dept Pharmacol, Granada 18071, Spain, International Excellence Campus of the Sea (CEI.MAR), [Cabeza,L, Peña,M, Mesas,C, Perazzoli,G, Prados,J, Melguizo,C] Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada, Spain. [Cabeza,L, Melguizo,C] Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. [Cabeza,L, Melguizo,C] Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, Granada, Spain. [Martínez,R, Porres,JM] Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM),Department of Physiology, University of Granada, Granada, Spain. [Galisteo,C] Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain., and This research was funded by the International Excellence Campus of the Sea (CEI·MAR) through the Projects CEIJ-007 and CEIJ-0012.
Subjects: Antioxidant, medicine.medical_treatment, Organisms::Eukaryota::Animals::Invertebrates::Cnidaria::Anthozoa::Sea Anemones [Medical Subject Headings], antioxidant activity, Antioxidantes, Phenomena and Processes::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Digestive System Processes::Digestion [Medical Subject Headings], Symbiodinium, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings], 0302 clinical medicine, Neoplasias colorrectales, Organisms::Eukaryota::Animals [Medical Subject Headings], lcsh:QH301-705.5, chemistry.chemical_classification, 0303 health sciences, biology, Anemone, Chemicals and Drugs::Lipids::Fatty Acids [Medical Subject Headings], Biochemistry, 030220 oncology & carcinogenesis, Digestión, Digestion, General Agricultural and Biological Sciences, Polyunsaturated fatty acid, Cell death, Programmed cell death, Anemonia sulcata, colorectal cancer, Publication Type::Study Characteristics::In Vitro [Medical Subject Headings], Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, antitumor activity, 030304 developmental biology, General Immunology and Microbiology, Fatty acid, Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [Medical Subject Headings], biology.organism_classification, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death [Medical Subject Headings], In vitro, Muerte celular, Chemicals and Drugs::Complex Mixtures::Biological Products [Medical Subject Headings], lcsh:Biology (General), chemistry, Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated [Medical Subject Headings]
Abstract: Simple Summary: Colorectal cancer is one of the most frequent types of cancer in the population. Recently, invertebrate marine animals have been investigated for the presence of natural products which can damage tumor cells, prevent their spread to other tissues or avoid cancer develop. We analyzed the anemone Anemonia sulcata with and without the presence of its microalgal symbiont (Symbiodinium) as a source of bioactive molecules for the colorectal cancer therapy and prevention. Colon cancer tumor cells were exposed to Anemone extracts observing a remarkable cell death and a great antioxidant capacity. These preliminary results support that Anemonia sulcata could be a source of bioactive compounds against colorectal cancer and that the absence of its symbiont may enhance these properties. Further studies will be necessary to define the bioactive compounds of Anemonia sulcata and their mechanisms of action. Abstract: Recently, invertebrate marine species have been investigated for the presence of natural products with antitumor activity. We analyzed the invertebrate Anemonia sulcata with (W) and without (W/O) the presence of its microalgal symbiont Symbiodinium as a source of bioactive compounds that may be applied in the therapy and/or prevention of colorectal cancer (CRC). Animals were mechanically homogenized and subjected to ethanolic extraction. The proximate composition and fatty acid profile were determined. In addition, an in vitro digestion was performed to study the potentially dialyzable fraction. The antioxidant and antitumor activity of the samples and the digestion products were analyzed in CRC cells in vitro. Our results show a high concentration of polyunsaturated fatty acid in the anemone and a great antioxidant capacity, which demonstrated the ability to prevent cell death and a high antitumor activity of the crude homogenates against CRC cells and multicellular tumor spheroids, especially W/O symbiont. These preliminary results support that Anemonia sulcata could be a source of bioactive compounds with antioxidant and antitumor potential against CRC and that the absence of its symbiont may enhance these properties. Further studies will be necessary to define the bioactive compounds of Anemonia sulcata and their mechanisms of action., International Excellence Campus of the Sea (CEI.MAR) CEIJ-007 CEIJ-0012
Published: 2021

32. Analysis of the Costs Associated With the Elective Evaluation of Patients Labelled as Allergic to Beta-Lactams or Nonsteroidal Antiinflamatory Agents

Author: Sobrino-García, Miriam, Moreno, Esther M., Muñoz-Bellido, Francisco J., Gracia-Bara, Maria T., Laffond, Elena, Doña, Inmaculada, Martín, Cristina, Macías, Eva M., de Arriba, Sonia, Campanón, Valle, Gallardo, Alicia, Dávila, Ignacio, [Sobrino-Garcia, Miriam] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Moreno, Esther M.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Munoz-Bellido, Francisco J.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Gracia-Bara, Maria T.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Laffond, Elena] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Martin, Cristina] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Macias, Eva M.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [de Arriba, Sonia] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Campanon, Valle] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Gallardo, Alicia] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Davila, Ignacio] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Moreno, Esther M.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Munoz-Bellido, Francisco J.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Gracia-Bara, Maria T.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Laffond, Elena] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Martin, Cristina] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Macias, Eva M.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [de Arriba, Sonia] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Davila, Ignacio] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Moreno, Esther M.] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Munoz-Bellido, Francisco J.] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Laffond, Elena] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Macias, Eva M.] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [de Arriba, Sonia] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Davila, Ignacio] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Moreno, Esther M.] Salamanca Univ Hosp, Asthma Allerg & Adverse React ARADyAL, Network Cooperat Res Hlth, Inst Salud Carlos III, Salamanca, Spain, [Dona, Inmaculada] Salamanca Univ Hosp, Asthma Allerg & Adverse React ARADyAL, Network Cooperat Res Hlth, Inst Salud Carlos III, Salamanca, Spain, [Davila, Ignacio] Salamanca Univ Hosp, Asthma Allerg & Adverse React ARADyAL, Network Cooperat Res Hlth, Inst Salud Carlos III, Salamanca, Spain, [Dona, Inmaculada] Univ Hosp Malaga, Allergy Serv, Malaga, Spain, [Dona, Inmaculada] Biomed Res Inst Malaga IBIMA, Malaga, Spain, [Sobrino-García,M, Moreno,EM, Muñoz-Bellido,FJ, Gracia-Bara,MT, Laffond,E, Martín,C, Macías,EM, de Arriba,S, Campanón,V, Gallardo,A, Dávila,I] Allergy Service, University Hospital of Salamanca, Salamanca, Spain. [Moreno,EM, Dávila,I] Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain. [Moreno,EM, Dávila,I] Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain. [Moreno,EM, Doña,I, and Dávila,I] Asthma, Allergic and Adverse Reactions (ARADyAL), Network for Cooperative Research in Health of Instituto de Salud Carlos III, Salamanca University Hospital, Salamanca, Spain. [Doña,I] Allergy Service, University Hospital of Malaga, Malaga, Spain. [Doña,I] Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain.
Subjects: History, Hypersensitivity reactions, Reported penicillin allergy, Adolescents, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], non-steroidal anti-inflammatory drug, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings], Antiinflammatory drugs, cost, Diagnosis, Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams [Medical Subject Headings], Persons::Persons::Age Groups::Child [Medical Subject Headings], Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis [Medical Subject Headings], Persons::Persons::Age Groups::Adult [Medical Subject Headings], Aspirin desensitization, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents::Anti-Inflammatory Agents, Non-Steroidal [Medical Subject Headings], Penicilinas, Beta-lactamas, Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins [Medical Subject Headings], Classification, Management, Costos y análisis de costo, Diseases::Chemically-Induced Disorders::Drug-Related Side Effects and Adverse Reactions::Drug Hypersensitivity [Medical Subject Headings], penicillin, Impact, delabelling, Hipersensibilidad a las drogas, Antiinflamatorios no esteroideos, beta-lactam, drug hypersensitivity, drug allergy
Abstract: Introduction: Being labelled as allergic to different drugs results in patients receiving other treatments, which are more toxic, less effective and more expensive. We aimed to analyze different studies of the costs of drug hypersensitivity assessment. Methods: A bibliographic search on studies regarding this issue was performed, including the available scientific evidence up to June 2020. We searched three databases with terms related to costs and allergy testing in drug hypersensitivity reactions. Results: Our search revealed 1,430 publications, of which 20 met the inclusion criteria. In the manuscript, prospective studies evaluating the costs of the evaluation of patients with suspected allergy to beta-lactams or non-steroidal anti-inflammatory drugs are analyzed. Also, comment is made on the costs associated with incorrect labeling as non-steroidal anti-inflammatory drug or penicillin hypersensitivity. Conclusions: Taking all costs into account, the study of drug hypersensitivity is not expensive, particularly considering the economic and clinical consequences of labeling a patient with hypersensitivity to drugs. Yes
Published: 2020

33. Validation of the 1,4-butanediol thermoplastic polyurethane as a novel material for 3D bioprinting applications

Author: Elvira Montañez, Juan A. Marchal, Elena López-Ruiz, Macarena Perán, Esmeralda Carrillo, Gema Jiménez, Juan de Vicente, Carlos Chocarro-Wrona, Cristina Antich, Patricia Gálvez-Martín, Daniel Martínez-Moreno, [Chocarro-Wrona,C, Antich,C, Jiménez,G, Martínez-Moreno,D, Carrillo,E, Perán,M, López-Ruiz,E, Marchal,JA] Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, Spain. [Chocarro-Wrona,C, Marchal,JA] Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain. [Chocarro-Wrona,C, Marchal,JA] Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. [Chocarro-Wrona,C, de Vicente,J, Marchal,JA] Excellence Research Unit 'Modeling Nature' (MNat), University of Granada, Granada, Spain. [de Vicente,J] Department of Applied Physics, Faculty of Sciences, University of Granada, Granada, Spain. [Montañez,E] Biomedical Research Institute of Málaga (IBIMA), Málaga. [Montañez,E] Department of Orthopedic Surgery and Traumatology, Virgen de la Victoria University Hospital, Málaga, Spain. [Gálvez-Martín,P] Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada, Spain. [Gálvez-Martín,P] Advanced Therapies Area, Bioibérica S.A.U, Barcelona, Spain. [Perán,M, López-Ruiz,E] Department of Health Sciences, University of Jaén, Jaén, Spain, Consejería de Economía, Innovación, Empresas y Universidad de la Junta de Andalucía and European Regional Development Fund, Grant/Award Number: SOMM17/6109/UGR, Ministerio de Economía, Indsutria y Competitividad. Gobierno de España, Grant/Award Numbers: MAT 2016-78778-R, PCIN-2015-051, Fundación Mutua Madrileña, Grant/Award Number: FMM-AP17196-2019., [Chocarro-Wrona, Carlos] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Antich, Cristina] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Jimenez, Gema] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Martinez-Moreno, Daniel] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Carrillo, Esmeralda] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Peran, Macarena] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Lopez-Ruiz, Elena] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Marchal, Juan Antonio] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Granada, Spain, [Chocarro-Wrona, Carlos] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Antich, Cristina] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Jimenez, Gema] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Martinez-Moreno, Daniel] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Carrillo, Esmeralda] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Peran, Macarena] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Lopez-Ruiz, Elena] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Marchal, Juan Antonio] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain, [Chocarro-Wrona, Carlos] Univ Granada, Fac Med, Dept Human Anat & Embryol, Granada, Spain, [Antich, Cristina] Univ Granada, Fac Med, Dept Human Anat & Embryol, Granada, Spain, [Martinez-Moreno, Daniel] Univ Granada, Fac Med, Dept Human Anat & Embryol, Granada, Spain, [Carrillo, Esmeralda] Univ Granada, Fac Med, Dept Human Anat & Embryol, Granada, Spain, [Marchal, Juan Antonio] Univ Granada, Fac Med, Dept Human Anat & Embryol, Granada, Spain, [Chocarro-Wrona, Carlos] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [de Vicente, Juan] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [Antich, Cristina] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [Jimenez, Gema] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [Martinez-Moreno, Daniel] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [Carrillo, Esmeralda] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [Peran, Macarena] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [Lopez-Ruiz, Elena] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [Marchal, Juan Antonio] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain, [de Vicente, Juan] Univ Granada, Dept Appl Phys, Fac Sci, Granada, Spain, [Montanez, Elvira] Biomed Res Inst Malaga IBIMA, Malaga, Spain, [Montanez, Elvira] Virgen Victoria Univ Hosp, Dept Orthoped Surg & Traumatol, Malaga, Spain, [Galvez-Martin, Patricia] Univ Granada, Sch Pharm, Dept Pharm & Pharmaceut Technol, Granada, Spain, [Galvez-Martin, Patricia] Bioiber SAU, Adv Therapies Area, Barcelona, Spain, [Peran, Macarena] Univ Jaen, Dept Hlth Sci, Jaen, Spain, [Lopez-Ruiz, Elena] Univ Jaen, Dept Hlth Sci, Jaen, Spain, Consejeria de Economia, Innovacion, Empresas y Universidad de la Junta de Andalucia, European Regional Development Fund, Ministerio de Economia, Indsutria y Competitividad. Gobierno de Espana, and Fundacion Mutua Madrilena
Subjects: Research Report, Pharmaceutical Science, MSCs, Elastómeros, law.invention, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Tissue engineering, law, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Culture Techniques::Cell Engineering::Tissue Engineering [Medical Subject Headings], Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Biomedical and Dental Materials::Biocompatible Materials [Medical Subject Headings], 1,4-butanediol thermoplastic polyurethane, Poliuretanos, Biomaterial, Hydrogels, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Bioprinting [Medical Subject Headings], medicine.anatomical_structure, Elastomers, Chemicals and Drugs::Macromolecular Substances::Polymers::Polyesters [Medical Subject Headings], tissue engineering, Anatomy::Musculoskeletal System::Cartilage::Hyaline Cartilage::Cartilage, Articular [Medical Subject Headings], TP155-156, Collagen, Mesenchymal stem-cells, Chondrogenesis, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Microscopy::Microscopy, Confocal [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Alcohols::Glycols::Butylene Glycols [Medical Subject Headings], Biotechnology, Biofabrication, Design, Materials science, Biocompatibility, Condrogénesis, Mechanical-properties, Biomedical Engineering, Células madre mesenquimatosas, Elastomer, RM1-950, Fabrication, Thermoplastic polyurethane, 1,4‐butanediol thermoplastic polyurethane, Chemical engineering, Pcl scaffolds, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival [Medical Subject Headings], Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Musculoskeletal Development::Chondrogenesis [Medical Subject Headings], medicine, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Scleroproteins::Extracellular Matrix Proteins [Medical Subject Headings], Cartilage tissue, Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Elasticity [Medical Subject Headings], elastomer, 3D bioprinting, Matrix, Cartilage, Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Mechanical Processes::Weight-Bearing [Medical Subject Headings], Tissue enginering, Research Reports, Bioimpresión, Autologous chondrocyte implantation, Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Elastomers::Polyurethanes [Medical Subject Headings], Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Friction [Medical Subject Headings], Therapeutics. Pharmacology, Ingeniería de tejidos, TP248.13-248.65, Biomedical engineering
Abstract: Tissue engineering (TE) seeks to fabricate implants that mimic the mechanical strength, structure, and composition of native tissues. Cartilage TE requires the development of functional personalized implants with cartilage-like mechanical properties capable of sustaining high load-bearing environments to integrate into the surrounding tissue of the cartilage defect. In this study, we evaluated the novel 1,4-butanediol thermoplastic polyurethane elastomer (b-TPUe) derivative filament as a 3D bioprinting material with application in cartilage TE. The mechanical behavior of b-TPUe in terms of friction and elasticity were examined and compared with human articular cartilage, PCL, and PLA. Moreover, infrapatellar fat pad-derived human mesenchymal stem cells (MSCs) were bioprinted together with scaffolds. in vitro cytotoxicity, proliferative potential, cell viability, and chondrogenic differentiation were analyzed by Alamar blue assay, SEM, confocal microscopy, and RT-qPCR. Moreover, in vivo biocompatibility and host integration were analyzed. b-TPUe demonstrated a much closer compression and shear behavior to native cartilage than PCL and PLA, as well as closer tribological properties to cartilage. Moreover, b-TPUe bioprinted scaffolds were able to maintain proper proliferative potential, cell viability, and supported MSCs chondrogenesis. Finally, in vivo studies revealed no toxic effects 21 days after scaffolds implantation, extracellular matrix deposition and integration within the surrounding tissue. This is the first study that validates the biocompatibility of b-TPUe for 3D bioprinting. Our findings indicate that this biomaterial can be exploited for the automated biofabrication of artificial tissues with tailorable mechanical properties including the great potential for cartilage TE applications., Consejería de Economía, Innovación, Empresas y Universidad de la Junta de Andalucía SOMM17/6109/UGR, European Union (EU) SOMM17/6109/UGR, Ministerio de Economía, Industria y Competitividad. Gobierno de España MAT 2016-78778-R PCIN-2015-051, Instituto de Salud Carlos III FMM-AP17196-2019
Published: 2020

34. Ambulatory blood pressure monitoring during pregnancy: an Italian experience

Author: A. Coppola, M. A. Rodríguez Borrego, Fabio Fabbian, E Di Simone, Pantaleo Greco, A De Giorgi, Rosaria Cappadona, P. J. López Soto, S. Fanaro, Roberto Manfredini, [Fabbian, F.] Univ Ferrara, Univ Hosp St Anna, Dept Med Sci, Fac Med Pharm & Prevent,Hypertens Ctr, Ferrara, Italy, [De Giorgi, A.] Univ Ferrara, Univ Hosp St Anna, Dept Med Sci, Fac Med Pharm & Prevent,Hypertens Ctr, Ferrara, Italy, [Manfredini, R.] Univ Ferrara, Univ Hosp St Anna, Dept Med Sci, Fac Med Pharm & Prevent,Hypertens Ctr, Ferrara, Italy, [Fabbian, F.] Univ Ferrara, Univ Hosp St Anna, Clin Med Unit, Fac Med Pharm & Prevent, Ferrara, Italy, [De Giorgi, A.] Univ Ferrara, Univ Hosp St Anna, Clin Med Unit, Fac Med Pharm & Prevent, Ferrara, Italy, [Manfredini, R.] Univ Ferrara, Univ Hosp St Anna, Clin Med Unit, Fac Med Pharm & Prevent, Ferrara, Italy, [Coppola, A.] Univ Ferrara, Dept Morphol Surg & Expt Med, Univ Hosp St Anna, Obstet & Gynecol Unit,Fac Med Pharm & Prevent, Ferrara, Italy, [Cappadona, R.] Univ Ferrara, Dept Morphol Surg & Expt Med, Univ Hosp St Anna, Obstet & Gynecol Unit,Fac Med Pharm & Prevent, Ferrara, Italy, [Greco, P.] Univ Ferrara, Dept Morphol Surg & Expt Med, Univ Hosp St Anna, Obstet & Gynecol Unit,Fac Med Pharm & Prevent, Ferrara, Italy, [Fanaro, S.] Univ Ferrara, Dept Med Sci, Univ Hosp St Anna, Pediat & Neonatol Unit,Fac Med Pharm & Prevent, Ferrara, Italy, [Di Simone, E.] Univ Hosp St Anna, Gen Med, Ferrara, Italy, [Fabbian, F.] Univ Cordoba, Maimonides Inst Biomed Res Cordoba, Fac Med & Nursing, Cordoba, Spain, [Manfredini, R.] Univ Cordoba, Maimonides Inst Biomed Res Cordoba, Fac Med & Nursing, Cordoba, Spain, [Rodriguez Borrego, M. A.] Univ Cordoba, Maimonides Inst Biomed Res Cordoba, Fac Med & Nursing, Cordoba, Spain, [Lopez Soto, P. J.] Univ Cordoba, Maimonides Inst Biomed Res Cordoba, Fac Med & Nursing, Cordoba, Spain, and University of Ferrara (Fondo Ateneo Ricerca FAR)
Subjects: High risk antenatal clinic, Risk, medicine.medical_specialty, Pregnancy, Ambulatory blood pressure, business.industry, Hypertensive disorders, Socio-culturale, Obstetrics and Gynecology, Guidelines, medicine.disease, Management, Reproductive Medicine, Emergency medicine, Hypertension, Diagnosis, Medicine, High risk antenatal clinic, Pregnancy, Hypertension, Obesity, Ambulatory blood pressure monitoring, Obesity, Ambulatory blood pressure monitoring, business, LS4_7
Abstract: Objective: To describe the impact of a collaborative Italian diagnostic pathway offering ambulatory blood pressure (BP) monitoring (ABPM) in High Risk Antenatal Clinic (HRAC) pregnant women. The study included 395 pregnant women evaluated at HRAC between 2012 and 2016, while analyzing demographic, clinical characteristics, and prescription of ABPM. Pregnant women were firstly seen when gestational age was 19.6 +/- 9.6 weeks. In at least one-third of cases, ABPM was followed by medical intervention aiming to modify the pre-existing therapeutic treatment. Hypertension and overweight were the main reasons for performing ABPM. WCH: white-coat hy-pertension.
Published: 2020

35. Posttreatment Effects ofOlea EuropaeaL. Leaf Extract on Carbon Tetrachloride-Induced Liver Injury and Oxidative Stress in Rats

Author: Derya Ustuner, Emine Colak, Dilek Burukoglu Donmez, Ertugrul Colak, Murat Dinçer, Umut Kerem Kolac, Mehmet Cengiz Ustuner, Neslihan Tekin, Emre Entok, Fahrettin Akyüz, Sabire Yazıcı Fen Edebiyat Fakültesi, Dincer, Murat -- 0000-0001-7110-4155, and [Ustuner, Derya] Eskisehir Osmangazi Univ, Vocat Sch Hlth Serv, Dept Med Lab, Eskisehir, Turkey -- [Colak, Emine -- Kolac, Umut Kerem -- Ustuner, Mehmet Cengiz] Eskisehir Osmangazi Univ, Fac Med, Dept Med Biol, Meselik Campus, TR-26040 Eskisehir, Turkey -- [Dincer, Murat] Eskisehir Osmangazi Univ, Fac Med, Dept Med Oncol, Eskisehir, Turkey -- [Tekin, Neslihan] Aksaray Univ, Dept Biotechnol & Mol Biol, Aksaray, Turkey -- [Donmez, Dilek Burukoglu] Eskisehir Osmangazi Univ, Fac Med, Dept Histol & Embryol, Eskisehir, Turkey -- [Akyuz, Fahrettin] Eskisehir Osmangazi Univ, Fac Med, Dept Med Biochem, Eskisehir, Turkey -- [Colak, Ertugrul] Eskisehir Osmangazi Univ, Fac Med, Dept Biostat & Med Informat, Eskisehir, Turkey -- [Entok, Emre] Eskisehir Osmangazi Univ, Fac Med, Dept Nucl Med, Eskisehir, Turkey
Subjects: p53, Male, 0301 basic medicine, Liver Damage, Medicine (miscellaneous), CCL4, DNA Fragmentation, Pharmacology, medicine.disease_cause, Antioxidants, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Malondialdehyde, Olea, medicine, Animals, Humans, Aspartate Aminotransferases, Liver damage, Carbon Tetrachloride, Liver injury, Nutrition and Dietetics, biology, Plant Extracts, Superoxide Dismutase, Alanine Transaminase, medicine.disease, biology.organism_classification, Glutathione, Rats, Plant Leaves, Oxidative Stress, 030104 developmental biology, Liver, chemistry, 030220 oncology & carcinogenesis, Carbon tetrachloride, DNA fragmentation, Lipid Peroxidation, Chemical and Drug Induced Liver Injury, Oxidative stress, DNA Damage
Abstract: WOS: 000444689300007, PubMed: 29648970, The aim of this study is to examine the therapeutic effects of Olea europaea L. leaf extract on carbon tetrachloride (CCl4)-induced liver damage in rats. In the experiments, 3- to 4-month-old 28 male Sprague-Dawley rats were divided into four groups: control, O. europaea leaf extract, CCl4, and curative. The CCl4 and curative groups received CCl4 (0.2mL/kg) intraperitoneally for 10 days to form hepatic injury. O. europaea (80mg/kg) leaf extract was given orally to the curative group dissolved in distilled water the following 14 days. Hepatic and antioxidant enzyme levels, p53, caspase 3, lipid peroxidation marker malondialdehyde (MDA), and also DNA fragmentation levels were determined to establish oxidative stress in hepatic cell damage and its consequences. After formation of liver damage, oral administration of the O. europaea significantly reduced CCl4-induced elevations of serum alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase levels (P
Published: 2018

36. An in vitro Study of Cytotoxic Activity of Euphorbia macroclada boiss on Mcf–7 Cells

Author: Ayca Tas, Serap Sahin-Bolukbaşı, Esranur Cevik, Esma Ozmen, Erkan Gumus, Yavuz Silig, and [Tas, Ayca] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Diet, Sivas, Turkey -- [Sahin-Bolukbasi, Serap -- Cevik, Esranur] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkey -- [Ozmen, Esma -- Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Biochem, Sivas, Turkey -- [Gumus, Erkan] Cumhuriyet Univ, Fac Med, Dept Histol, Sivas, Turkey -- [Gumus, Erkan] Cumhuriyet Univ, Fac Med, Dept Embryol, Sivas, Turkey
Subjects: 0301 basic medicine, 030109 nutrition & dietetics, Cytotoxic activity, Traditional medicine, Chemistry, Euphorbia macroclada boiss, 03 medical and health sciences, Breast cancer, MCF-7, Euphorbia macroclada, Cytotoxic T cell, In vitro study, General Pharmacology, Toxicology and Pharmaceutics
Abstract: WOS: 000454950700019, Objective: The study was aimed to evaluate the cytotoxic activity of acetone extract of leaves, flower and body of Euphorbia macroclada boiss on human breast cancer cell line (MCF-7). Material: The cells were plated at a cell density of 1x10(5) cells in 96-well plates and grown with DMEM medium containing supplemented with 10% FBS and 1% penicillin. The cells were treated by different concentrations of acetone extract of Euphorbia macroclada boiss (10-1000 mu g/mL) during 24, 48 and 72 h. The cytotoxic activities of the tested compounds were determined by cell proliferation analysis using standard (3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: After the evaluation of cytotoxicity assay results, it is determined that flower and body parts have a significant cytotoxic effect on MCF-7 breast cancer cell line. The values that obtained reading at 570 nm spectrophotometrically, were analyzed with GraphPad Prism7 and IC50 growth inhibition values was determined. Conclusion: The results of MTT assay showed that leaves, flower and body significantly reduced % cell viability comparative to the control. It was also shown that body had more growth inhibitory effect on MCF-7 cell compared to the leaves part.
Published: 2018

37. Are Fetuin-A levels beneficial for estimating timing of sepsis occurrence?

Author: Tuncer Şimşek, Sema Uysal, Yavuz Demiraran, Hatice Betül Altinişik, Suzan Sacar, Uğur Altınışık, Altinisik, Hatice B., Simsek, Tuncer Canakkale Onsekiz Mart Univ, Fac Med, Dept Anesthesiol & Reanimat, Canakkale, Turkey, Uysal, Sema Canakkale Onsekiz Mart Univ, Fac Med, Dept Biochem, Canakkale, Turkey, Altinisik, Ugur Izmiryolu Sevgi Hosp, Anesthesiol & Reanimat, Balikesir, Turkey, Sacar, Suzan Izmiryolu Sevgi Hosp, Infect Dis & Clin Microbiol, Balikesir, Turkey, and Demiraran, Yavuz Medipol Univ, Fac Med, Dept Anesthesiol & Reanimat, Istanbul, Turkey
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Turkey, alpha-2-HS-Glycoprotein, lcsh:Medicine, 030209 endocrinology & metabolism, Gastroenterology, Procalcitonin, law.invention, Sepsis, Leukocyte Count, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, law, Internal medicine, White blood cell, medicine, Humans, Timing, Aged, 030109 nutrition & dietetics, business.industry, lcsh:R, Significant difference, Estimating Timing, General Medicine, Middle Aged, University hospital, medicine.disease, Intensive care unit, Fetuin, Fetuin-A, C-Reactive Protein, medicine.anatomical_structure, Levels Beneficial, Female, business
Abstract: Objectives: To evaluated Fetuin-A levels of patients admitted in the intensive care unit with a diagnosis of sepsis. Methods : This study was conducted at the Faculty of Medicine, Canakkale Onsekiz Mart University Hospital, Canakkal, Turkey, between February 2015 and October 2015. Forty septic patients were included in the study. Subsequent to clinical suspicion of sepsis, serum levels of C-reactive protein (CRP) and procalcitonin; and white blood cell (WBC) counts were evaluated at 3 time-points: 0 (basal), 24, and 72 hours. Results : The mean Fetuin-A levels at the 3 time-points were 58.5 ± 29.2 ng/mL, 40.9 ± 23.6 ng/mL, and 47.8 ± 25.7 ng/mL, respectively. Fetuin-A levels at 24 hours were significantly lower than the basal level ( p greater than 0.05), where as no significant difference was observed between the basal levels and those at 72 hours ( p greater than 0.05). Correlation between the temporal changes in Fetuin-A levels and the changes in other inflammatory markers (CRP, procalcitonin and WBC) was examined. Fetuin A was found to have only a negative correlation with serum procalcitonin level ( p less than 0.05). Conclusion : In this study, serum Fetuin-A levels in septic patients decreased significantly in the first 24 hours, followed by an insignificant increase at 72 hours. These findings suggest that monitoring of Fetuin-A levels may help predict the time of occurrence of sepsis and prognosis of sepsis. Saudi Med J 2018; Vol. 39 (7): 679-684 doi: 10.15537/smj.2018.7.22418 How to cite this article: Altinisik HB, Altinisik U, Uysal S, Sacar S, Simsek T, Demiraran Y.Are Fetuin-A levels beneficial for estimating timing of sepsis occurrence? Saudi Med J . 2018 Jul;39(7):679-684. doi: 10.15537/smj.2018.7.22418.
Published: 2018

38. Comparison of dialysate and plasma NTproBNP in prediction of clinical outcomes of diabetic and nondiabetic peritoneal dialysis patients

Author: Sema T. Koz, İdris Şahin, Mansur Kayataş, Suleyman Koz, and [Koz, Suleyman -- Sahin, Idris] Inonu Univ, Fac Med, Dept Nephrol, Malatya, Turkey -- [Kayatas, Mansur] Cumhuriyet Univ, Fac Med, Dept Nephrol, Sivas, Turkey -- [Koz, Sema Tulay] Malatya State Hosp, Dept Lab Med & Dialysis Unit, Malatya, Turkey
Subjects: Male, medicine.medical_specialty, Membrane permeability, medicine.drug_class, medicine.medical_treatment, 030232 urology & nephrology, 030204 cardiovascular system & hematology, dropout, Peritoneal dialysis, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Dialysis Solutions, Statistical significance, Diabetes mellitus, Internal medicine, Natriuretic Peptide, Brain, Diabetes Mellitus, medicine, Natriuretic peptide, Humans, natriuretic peptide, business.industry, General Medicine, Odds ratio, medicine.disease, mortality, Peptide Fragments, peritoneal dialysis, Nephrology, Ambulatory, Female, Hemodialysis, NTproBNP and diabetes, business, Peritoneal Dialysis, dialysate NTproBNP
Abstract: WOS: 000435373000005, PubMed ID: 29350172, Background: Plasma level of N-terminal pro-brain natriuretic peptide (P-NTproBNP) is a useful marker in prediction of mortality in peritoneal dialysis (PD) patients. However, the predictive value of spent dialysate counterpart (D-NTproBNP) of plasma NTproBNP on mortality and dropout is not known. Materials and methods: Simultaneous P-NTproBNP and D-NTproBNP assays were performed after an overnight dwell in 44 scheduled ambulatory PD patients. Patients were followed for similar to 47 months. Deceased patients or patients who were transferred to hemodialysis were regarded as dropouts. Results: 14 patients (31.8%) dropped out at similar to 4 years (9 deaths and 5 transfers to hemodialysis). Diabetics, males, and patients with higher membrane permeability had higher dropout rates. Patients with P-and D-NTproBNP higher than median values had higher mortality and dropout rates (Kaplan-Meier test, log-rank Test p < 0.05). Odds ratios of D-NTproBNP for death and dropouts were (3.807 (0.907-15.971), p = 0.068) and (2.87 (1.009-8.138) p = 0.048), respectively; odds ratios of P-NTproBNP for death and dropouts were (4.652 (0.914-23.693), p = 0.064) and (2.67 (0.924-7.716), p = 0.07), respectively; in ROC analysis for death, AUC for P-and D-NTproBNP were 0.762 (0.578-0.946, p = 0.016) and 0.765 (0.590-0.940, p = 0.015), respectively. Exclusion of diabetic patients from the analyses resulted in significant changes in the predictive value P-and D-NTproBNP. Although death and dropout rates were still higher in nondiabetic patients with higher NTproBNP levels, the differences between groups lost statistical significance. Conclusion: Both P-NTproBNP and D-NTproBNP are significant predictors of outcomes of interest. Predictive value of NTproBNP might be different in diabetics and non-diabetic CAPD patients., Inonu University (INUBAP) [2012/97], The study was conducted through a grant obtained from Inonu University (INUBAP, Project No: 2012/97).
Published: 2018

39. MicroRNA-221/222 expression in atherosclerotic coronary artery plaque versus internal mammarian artery and in peripheral blood samples

Author: Aslihan Esra Bildirici, Öcal Berkan, Serdal Arslan, Mehmet Yilmaz, Osman Beton, Nil Ozbilum Sahin, and [Bildirici, Aslihan Esra -- Arslan, Serdal] Cumhuriyet Univ, Fac Med, Dept Med Biol, Sivas, Turkey -- [Sahin, Nil Ozbilum] Cumhuriyet Univ, Fac Sci, Dept Mol Biol & Genet, Sivas, Turkey -- [Berkan, Ocal] Cumhuriyet Univ, Fac Med, Dept Cardiovasc Surg, Sivas, Turkey -- [Beton, Osman -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey
Subjects: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Hypercholesterolemia, Clinical Biochemistry, Gene Expression, Coronary Artery Disease, Disease, atherosclerotic plaque, 030204 cardiovascular system & hematology, Biochemistry, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, microRNA, Gene expression, medicine, Humans, Mammary Arteries, miR-221/222, Medical History Taking, Aged, business.industry, Case-control study, Middle Aged, Atherosclerosis, medicine.disease, Plaque, Atherosclerotic, Peripheral blood, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Case-Control Studies, Hypertension, gene expression, Female, Target gene, business, coronary artery disease, Biomarkers, Artery
Abstract: WOS: 000450866100008, PubMed ID: 29737876, Background: Atherosclerosis is a disease of the arterial wall with predilection to some sites on others. MicroRNAs (miRNAs) are a class of the non-coding RNAs regulating the target gene expression at post-transcriptional level. Different miRNAs were found at distinct stages of plaque development and expression of miRNAs' might play an important role in the local behaviour of atherosclerotic plaques. Objective: We aimed to investigate and compare mirR-221/222 expression levels in tissues and in circulation in patients with and without overt atherosclerosis. Methods: RNA was isolated from 40 tissues as 20 tissue samples from coronary artery atherosclerotic plaques (CAAP) and internal mammary arteries (IMA), obtained from same individual) and 80 blood (44 patients with atherosclerosis and 36 healthy subjects) samples. MiR-221/222 expression levels were measured using real time PCR. Results: Expression levels of miR-221 was significantly increased in CAAP compared with completely atherosclerosis-free IMA tissues with a 8.94 times fold-change (p = 0.015). The miR-221 expression in tissue samples was significantly different in patients with hypercholesterolemia (p = 0.010), hypertension (p = 0.018) and family history of CAD (p = 0.033) versus not. Expression of miR-222 was not statistically significant between the two tissue samples overall. Conclusions: MiR-221 may be a potential biomarker for local atherosclerotic behavior, Research Council of Cumhuriyet University Sivas [T-641]; TUBITAK, Turkey [214S031], This study was supported by the Research Council of Cumhuriyet University (Project No: T-641) Sivas and TUBITAK (Project No: 214S031), Turkey.
Published: 2018

40. Reevaluation of Mandibular Morphometry According to Age, Gender, and Side

Author: Zeliha Fazliogullari, Ali Sami Kivrak, Ismihan Ilknur Uysal, Ahmet Kağan Karabulut, Nadire Unver Dogan, Filiz Direk, Sağlık Hizmetleri Meslek Yüksekokulu, and [Direk, Filiz] Aksaray Univ, Vocat Sch Hlth Serv, Aksaray, Turkey -- [Uysal, Ismihan Ilknur] Necmettin Erbakan Univ, Meram Fac Med, Dept Anat, TR-42080 Konya, Turkey -- [Kivrak, Ali Sami] Private Medova Hosp, Dept Radiol, Konya, Turkey -- [Unver Dogan, Nadire -- Fazliogullari, Zeliha -- Karabulut, Ahmet Kagan] Selcuk Univ, Dept Anat, Fac Med, Konya, Turkey
Subjects: Adult, Male, Mandibular Ramus, Adolescent, Mandibular symphysis, Radiography, Mandibular canal, Mandible, Condyle, Young Adult, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Reference Values, Multidetector Computed Tomography, medicine, Humans, Gonial angle, 030216 legal & forensic medicine, Aged, Retrospective Studies, Mandibular Foramen, Orthodontics, biology, business.industry, Significant difference, MDCT, Mandibular Lingula, Mandibular foramen, 030206 dentistry, General Medicine, Middle Aged, biology.organism_classification, Lingula, stomatognathic diseases, medicine.anatomical_structure, Mandibular Symphysis, Otorhinolaryngology, Female, Surgery, Gonial Angle, business
Abstract: WOS: 000434304300093, PubMed: 29461369, Aim: This study aims to reevaluation the linear and angular measurements of mandibles with multidetector computed tomography (MDCT) that is a new method and used frequently in recent years. Materials and Methods: The archived MDCT images of 100 adult patients (age range, 15-74 years) without mandibular operation and trauma history were evaluated retrospectively. Mandibular ramus heights, maximal mandibular length, mandibular symphysis height, mandibular angles, and mandibular foramen distance measurements were performed on MDCT images. All measurement parameters were analyzed by gender, age groups, and sides. Results: Mandibular linear length measurements were higher in males than in females (P
Published: 2018

41. The Distribution of Different Types of Diabetes in Childhood: A Single Center Experience

Author: Tulay Guran, Belma Haliloglu, Enes Celik, Serpil Bas, Serap Turan, Saygin Abali, Zeynep Atay, Abdullah Bereket, Fuat Bugrul, Haliloglu, Belma, Abali, Saygin, Bugrul, Fuat, Celik, Enes, Bas, Serpil, Atay, Zeynep, Guran, Tulay, Turan, Serap, Bereket, Abdullah, Haliloglu, Belma Yeditepe Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Abali, Saygin Acibadem Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Bereket, Abdullah Marmara Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey, Bas, Serpil Necip Fazil City Hosp, Clin Pediat Endocrinol, Kahramanmaras, Turkey, Atay, Zeynep Medipol Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Turan, Serap -- 0000-0002-5172-5402, ABALI, SAYGIN -- 0000-0001-6552-2801, and Acibadem University Dspace
Subjects: Male, Pediatrics, medicine.medical_specialty, Diabetic ketoacidosis, endocrine system diseases, Adolescent, Turkey, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Type 2 diabetes, Gene mutation, DIAGNOSIS, Maturity onset diabetes of the young, 03 medical and health sciences, MELLITUS, 0302 clinical medicine, Endocrinology, Diabetes mellitus, ADOLESCENTS, medicine, PROGRAM, Humans, 030212 general & internal medicine, education, Child, childhood, Type 1 diabetes, education.field_of_study, business.industry, nutritional and metabolic diseases, Infant, POLISH CHILDREN, medicine.disease, HNF1A, PREVALENCE, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, REGISTRY, Child, Preschool, Pediatrics, Perinatology and Child Health, ONSET, YOUNG, MODY, Original Article, Female, type 2 diabetes, business
Abstract: Objective: Type 1 diabetes (T1D) is the most common cause of diabetes in childhood but type 2 diabetes (T2D) and maturity onset diabetes of the young (MODY) are emerging as noteworthy causes of diabetes at young ages. The aim is to determine the distribution, trends and clinical features of the different types of diabetes in childhood in one tertiary center. Methods: The records of children and adolescents aged 0-18 years who were diagnosed as “diabetes/persistent hyperglycemia” between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at diagnosis and type of diabetes were recorded. Results: Children and adolescents aged 0-18 years who were diagnosed "diabetes/persistent hyperglycemia" between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at the diagnosis and type of diabetes were recorded.The mean ± standard deviation age of 835 patients (48.7% females) at diagnosis was 8.8±4.4 years. Eighty-four percent of the patients were diagnosed as T1D, 5.7% as T2D, 5.3% as clinical MODY and 5% as being cases of other types of diabetes. The frequency of diabetic ketoacidosis (DKA) and severe DKA in T1D were 48.4% and 11.6%, respectively. Fourteen patients (29.2%) with T2D presented with ketosis and two of them (4.2%) had DKA at diagnosis. Antibody positivity was 83.1% in T1D and 14.8% in T2D. A statistically significant increase in the frequency of T2D has clearly been demonstrated in recent years with a frequency of 1.9%, 2.4% and 7.9% in 1999-2004, 2005-2010 and 2011-2016, respectively (p
Published: 2018

42. The protective effect and diagnostic performance of NOX-5 in Crimean–Congo haemorrhagic fever patients

Author: Aynur Engin, Mustafa Gökhan Gözel, Seyit Ali Büyüktuna, Nazif Elaldi, Halef Okan Doğan, Mehmet Bakir, and [Buyuktuna, Seyit Ali -- Bakir, Mehmet -- Elaldi, Nazif -- Gozel, Mustafa Gokhan -- Engin, Aynur] Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Dogan, Halef Okan] Cumhuriyet Univ, Fac Med, Dept Biochem, Sivas, Turkey
Subjects: Adult, Male, inorganic chemicals, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Turkey, Crimean-Congo haemorrhagic fever, Enzyme-Linked Immunosorbent Assay, Disease, 030204 cardiovascular system & hematology, Microbiology, Gastroenterology, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, CCHF, medicine, Humans, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, NADPH oxidase, biology, business.industry, Area under the curve, NOX-5, General Medicine, Middle Aged, NOX-1, Confidence interval, Pathophysiology, 030104 developmental biology, NADPH Oxidase 5, chemistry, Hemorrhagic Fever Virus, Crimean-Congo, biology.protein, Female, Hemorrhagic Fever, Crimean, business, Nicotinamide adenine dinucleotide phosphate
Abstract: WOS: 000429658500012, PubMed ID: 29509132, Introduction. Crimean-Congo haemorrhagic fever (CCHF) is an acute viral haemorrhagic disease. Reactive oxygen species that are mainly generated by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) enzyme family have a pivotal role in the pathophysiology of many diseases. The serum levels of NOX isoforms in patients with CCHF have yet to be assessed. Methods. This prospective study was conducted at Cumhuriyet University, Turkey. Only patients with CCHF confirmed by the National Reference Virology Laboratory were enrolled in the study. The study subjects comprised 67 CCHF patients and 70 healthy control subjects. The quantitative sandwich ELISA technique was used for the determination of serum NOX 1, 2, 4 and 5. Results. Higher median median NOX-1 (P=0.001) and NOX-5 (P, Cumhuriyet University [T-669], This study was supported by Cumhuriyet University with approval number T-669.
Published: 2018

43. Therapeutic and prophylactic effects of strontium on radiotherapy-induced skin toxicity in rats

Author: Seher Bahar, Sibel Berksoy Hayta, Melih Akyol, Eda Erdiş, Turgut Kaçan, Mustafa Gürol Celasun, Birsen Yücel, Ömer Fahrettin Göze, and [Yucel, Birsen -- Erdis, Eda -- Bahar, Seher -- Celasun, Mustafa Gurol] Cumhuriyet Univ, Fac Med, Dept Radiat Oncol, Sivas, Turkey -- [Hayta, Sibel Berksoy -- Akyol, Melih] Cumhuriyet Univ, Fac Med, Dept Dermatol, Sivas, Turkey -- [Goze, Omer Fahrettin] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Kacan, Turgut] Afyonkarahisar State Hosp, Clin Med Oncol, Afyon, Turkey
Subjects: Strontium, business.industry, medicine.medical_treatment, chemistry.chemical_element, Dermatology, Pharmacology, lcsh:RL1-803, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, skin toxicity, Radiation therapy, radiation, Skin toxicity, chemistry, lcsh:Dermatology, Medicine, business, dermatitis
Abstract: WOS: 000435795800001, Background and Design: This study aimed to investigate whether 5% strontium (Sr) chloride hexahydrate has preventive or therapeutic effects on the radiotherapy (RT)-induced adverse skin effects. Materials and Methods: Sixty-four female Wistar albino rats weighing 200-210 g, aged 4.5-5 months were divided into eight groups. Results: There were significant differences between control group and the other groups according to the Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria (RTOG) and histopathological findings (p0.05). In addition, there were no significant differences among treatment groups (p>0.05). Statistical results were as follows according to the immunohistochemical evaluation of transforming growth factor-beta: group 1 and 4 (p=0.015), group 1 and 5 (p=0.014), group 1 and 6 (p=0.035), group 1 and 8 (p=0.046), group 2 and 6 (p-0.047), group 4 and 6 (p=0.031); and according to the immunohistochemical evaluation of tumor necrosis factor-alpha: group 1 and 2 (p=0.024), group 1 and 8 (p=0.045). Conclusion: Topical treatment with Sr at a concentration of 5% is insufficient to prevent the side effects of RT involving the skin, as assessed by the RTOG scoring, histopathological findings, and immunological markers., Coordination Department of Scientific Research Projects of Cumhuriyet University [T607], This study was supported by Coordination Department of Scientific Research Projects of Cumhuriyet University. Project number: T607.
Published: 2017

44. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

Author: Fatma Betul Oktelik, Qian Chen, Metin Yusuf Gelmez, Mehdi Benamar, Ayca Kiykim, Ye Cui, Jason Jun Hung Fong, Achille Broggi, Jonathan Z. Li, Sreya Ghosh, Peggy S. Lai, Hani Harb, Murat Kose, Esin Aktas Cetin, Paola Contini, Jason W. Griffith, Ivan Zanoni, Talal A. Chatila, Lorenzo Berra, Elena Crestani, Ziwei Wang, Novalia Pishesha, Klaus Schmitz-Abe, Louis-Marie Charbonnier, Raffaele De Palma, Günnur Deniz, Gilberto Filaci, Emmanuel Stephen-Victor, Stephen C. Kolifrath, Xu G. Yu, Luca Marri, Hidde L. Ploegh, Genny Del Zotto, Boston Childrens Hosp, Division Immunology, Harvard Med Sch, Department pediatric, Massachusetts General Hospital, Div Pulm & Crit Care, Harvard Medical School - department medical, University Genoa, Dept Internal Medical, IRCCS Ospedale Policlinico San Martino [Genoa, Italy], IRCCS Istituto Giannina Gaslini [Genoa, Italy], Boston Childrens Hospital, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Istanbul Univ, Aziz Sancar Inst Expt Med Aziz Sancar DETAE, Istanbul Univ Cerrahpasa, Fac Med, Div Pediat Allergy & Immunol, Istanbul Univ, Fac Med, Dept Internal Med, Massachusetts Institute of Technology (MIT), Harvard Medical School [Boston] (HMS), and DUMENIL, Anita
Subjects: 0301 basic medicine, Il-6, Survival, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Severity of Illness Index, T-Lymphocytes, Regulatory, regulatory T cells, Mice, 0302 clinical medicine, Immunology and Allergy, Receptor, Notch4, Lung, ComputingMilieux_MISCELLANEOUS, Influenza-Virus, Immunity, Cellular, Protection, Immunohistochemistry, [SDV] Life Sciences [q-bio], Infectious Diseases, medicine.anatomical_structure, Cytokine, Influenza A virus, 030220 oncology & carcinogenesis, Host-Pathogen Interactions, Cytokines, Interleukin 18, Disease Susceptibility, amphiregulin, Inflammation Mediators, medicine.symptom, influenza, IL-18, Signal Transduction, Regulatory T cell, Pneumonia, Viral, Immunology, Activation, Mice, Transgenic, Inflammation, Biology, Amphiregulin, Article, Virus, Immunomodulation, 03 medical and health sciences, medicine, Animals, Humans, Interleukin 6, IL-6, Innate immune system, SARS-CoV-2, Notch4, Immunity, COVID-19, Disease Models, Animal, 030104 developmental biology, biology.protein, Biomarkers
Abstract: A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on circulating regulatory T (Treg) cells was associated with disease severity, predicted mortality, and declined upon recovery. Deletion of Notch4 in Treg cells or therapy with anti-Notch4 antibodies in conventional and humanized mice normalized the dysregulated innate immunity and rescued disease morbidity and mortality induced by a synthetic analog of viral RNA or by influenza H1N1 virus. Mechanistically, Notch4 suppressed the induction by interleukin-18 of amphiregulin, a cytokine necessary for tissue repair. Protection by Notch4 inhibition was recapitulated by therapy with Amphiregulin and, reciprocally, abrogated by its antagonism. Amphiregulin declined in COVID-19 subjects as a function of disease severity and Notch4 expression. Thus, Notch4 expression on Treg cells dynamically restrains amphiregulin-dependent tissue repair to promote severe lung inflammation, with therapeutic implications for COVID-19 and related infections., Graphical abstract, Harb, Benamar, et al. find that interleukin-6 increases Notch4 expression on lung regulatory T cells, which, in turn, restrains production of the tissue repair cytokine amphiregulin and promotes severe lung inflammation. Their findings have implications for treatment of COVID-19 and other respiratory viral infections.
Published: 2021

45. Neutrophil-to-Lymphocyte Ratio, Plateletto- Lymphocyte Ratio, and Red Blood Cell Distribution Width as New Biomarkers in Patients with Colorectal Cancer

Author: Abdulkerim Yilmaz, Sinan Soylu, Erol Çakmak, Özlem Yönem, [Cakmak, Erol -- Yonem, Ozlem -- Yilmaz, Abdulkerim] Cumhuriyet Univ, Fac Med, Dept Gastroenterol, Sivas, Turkey -- [Soylu, Sinan] Cumhuriyet Univ, Fac Med, Dept Surg, Sivas, Turkey, and Sivas Cumhuriyet Üniversitesi
Subjects: 0301 basic medicine, business.industry, Colorectal cancer, Lymphocyte, Red blood cell distribution width, medicine.disease, platelet-to-lymphocyte ratio, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, colon cancer, neutrophil-to-lymphocyte ratio, 030220 oncology & carcinogenesis, Immunology, Medicine, Platelet, In patient, red blood cell distribution width, Neutrophil to lymphocyte ratio, business, Genel ve Dahili Tıp, Biomarkers
Abstract: WOS: 000411484400007, Objective: The incidence of colorectal cancer in developed countries has been found to increase with age. Early diagnosis and screening decrease the mortality rates in colorectal cancer. This study aimed to use inflammatory markers neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW)as new biomarkers for early diagnosis and screening in patients with colorectal cancer. Materials and Methods: A total of 59 patients with colorectal cancer and 59 age-and sex-matched healthy participants were included in the study. Localization, tumor node metastasis (TNM) stage, and preoperative hemoglobin levels, neutrophil counts, lymphocyte counts, platelet counts, and RDW values were obtained from medical records. Using the receiver operating characteristic (ROC) curve, the optimal cutoff levels of the biomarkers were determined. Results: NLR, PLR, and RDW were significantly higher in patients with colorectal cancer than in healthy participants (p< 0.001). According to ROC analysis, the cutoff value for NLR was 2.05 [area under the curve (AUC): 0.740, sensitivity: 78%, specificity: 66%]; the cutoff value for PLR was 130 (AUC: 0.702, sensitivity: 65%, specificity: 72%); and the cutoff value for RDW was 14 (AUC: 0.774, sensitivity: 68%, specificity: 73%). Conclusions: NLR, PLR, and RDW were found to be significantly higher in patients with colorectal cancer than in healthy participants. Therefore, it is recommended that these additional biomarkers can be used for early diagnosis and screening of colorectal cancer.
Published: 2017

46. Investigation of the association between the MDM2 T309G polymorphism and gastric cancer

Author: Meriç Emre Bostancı, Omer Topcu, Yavuz Silig, Ayca Tas, Gulcin Caglayan, Serap Sahin Bolukbasi, Mustafa Atabey, and [Tas, Ayca] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Diet, TR-58140 Sivas, Turkey -- [Atabey, Mustafa -- Topcu, Omer] Cumhuriyet Univ, Fac Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Caglayan, Gulcin -- Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Bostanci, Meric Emre] Sivas Sample Hosp, Clin Gen Surg, TR-58060 Sivas, Turkey -- [Bolukbasi, Serap Sahin] Cumhuriyet Univ, Fac Pharmaceut, Dept Biochem, TR-58140 Sivas, Turkey
Subjects: 0301 basic medicine, Oncology, Turkish population, medicine.medical_specialty, Biology, medicine.disease_cause, Logistic regression, General Biochemistry, Genetics and Molecular Biology, polymorphism, MDM2 gene T309G, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genotype, medicine, General Pharmacology, Toxicology and Pharmaceutics, Family history, Oncogene, gastric cancer, General Neuroscience, Articles, General Medicine, Odds ratio, Confidence interval, 030104 developmental biology, 030220 oncology & carcinogenesis, Carcinogenesis
Abstract: WOS: 000417416000012, Murine double minute clone 2 oncoprotein (MDM2) is a key component in the regulation of the tumour suppressor p53. The association between the MDM2 polymorphism and gastric cancer (GC) has been investigated in Turkish population. In the present case-control study, the aim was to investigate the association between genetic polymorphisms of the MDM2 gene (a major regulator of p53 function) and primary GC risk in a Turkish population. The polymorphism, T309G (rs2279744) in the MDM2 gene was determined in patients with GC (n=65) and in healthy control subjects (n=67) using the polymerase chain reaction-restriction fragment length polymorphism method. The findings were evaluated using logistic regression and.2 tests. No statistically significant differences were observed between the control subjects and patients with GC regarding smoking status. A comparison between GC cases and control subjects indicated a statistically significant difference for family history of cancer [odds ratio (OR)=0.17; 95% confidence interval (CI), 0.05-0.56;.2=0.19; P=0.01]. A significant difference was identified in the GG genotype distribution between GC patients and control subjects (OR=4.58; 95% CI, 1.18-17.79; P=0.022). Thus, the results of the present study indicate that the MDM2 gene T309G intron (GG) genotype may be an important risk factor for GC development in the Turkish population., Cumhuriyet University [CUBAP T-547], This study was funded by Cumhuriyet University (grant no. CUBAP T-547).
Published: 2017

47. Effects of Curcumin on Alveolar Bone Loss in Experimental Periodontitis in Rats: A Morphometric and Histopathologic Study

Author: Aysan Lektemur Alpan, Nebi Cansın Karakan, Fahrettin Goze, Metin Çalişir, Aysun Akpinar, Ömer Poyraz, [Akpinar, Aysun] Cumhuriyet Univ, Fac Dent, Periodontol Dept, Sivas, Turkey -- [Calisir, Metin] Adiyaman Univ, Fac Dent, Periodontol Dept, TR-02140 Adiyaman, Turkey -- [Karakan, Nebi Cansin] Afyonkarahisar Saglik Bilimleri Univ, Fac Dent, Periodontol Dept, Afyon, Turkey -- [Alpan, Aysan Lektemur] Pamukkale Univ, Fac Dent, Periodontol Dept, Denizli, Turkey -- [Goze, Fahrettin] Cumhuriyet Univ, Fac Med, Pathol Dept, Sivas, Turkey -- [Poyraz, Omer] Cumhuriyet Univ, Fac Med, Microbiol Dept, Sivas, Turkey, and LEKTEMUR ALPAN, AYSAN -- 0000-0002-5939-4783
Subjects: 0301 basic medicine, Molar, medicine.medical_specialty, Curcumin, Antioxidant, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Medicine (miscellaneous), 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Osteoclast, Internal medicine, medicine, Ligature-induced, Dental alveolus, Periodontitis, Nutrition and Dietetics, Alveolar bone loss, business.industry, Osteoblast, 030206 dentistry, General Medicine, medicine.disease, Micronutrition, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Histomorphometric, Systemic administration, business
Abstract: WOS: 000468731900004, PubMed ID: 30272534, Background: Curcumin is found in the rhizomes of the turmeric plant that has been showed antioxidant and anti-inflammatory effect. The aim of this study was to evaluate the effects of systemic curcumin therapy on alveolar bone loss in an experimental periodontitis model in rats. Material and Methods: Thirty-two male Wistar rats were randomly divided to 4 groups: 75 mg/kg/daily curcumin (C75; n = 8), 150 mg/kg/daily curcumin (C150; n = 8), Control (n = 8), and Ligated (n = 8). Curcumin was administrated using gastric gavage. After 12 days, the rats were sacrificed. Right mandibles samples were histopathologically examined. Alveolar bone loss was measured. Interleukin 1 beta (IL-1 beta) and interleukin 10 (IL-10) were evaluated in the serum samples and gingival homogenates. Results: The measurements of alveolar bone loss in the mandibular molars revealed significantly higher bone-loss values in the Ligated group than the Control, C75 and C150 groups. The IL-1 beta levels in the gingival homogenates were significantly increased in the Ligated group compared to those of the Control, C75 and C150 groups. The serum IL-1 beta levels in the Ligated group were significantly higher than the Control group. The mean osteoblast numbers in the Ligated group were lower than those of the Control, C75 and C150 groups. The C150 groups showed significantly more osteoblasts than the Control group. The osteoclast numbers in the Ligated group increased significantly compared to the C75, C150 and control groups. Conclusion: This study demonstrates that systemic administration of curcumin at the 75 and 150mg/kg doses reduced alveolar bone loss in the periodontal disease in rats.
Published: 2017

48. Frequency of familial Mediterranean fever (MEFV) gene mutations in patients with biopsy-proven primary glomerulonephritis

Author: Binnur Bagci, Asim Gedikli, Meryem Timucin, Demet Alaygut, Ferhan Candan, Gokhan Bagci, Can Huzmeli, Mansur Kayataş, Ilhan Sezgin, Ali Yilmaz, and [Huzmeli, Can -- Candan, Ferhan -- Alaygut, Demet -- Timucin, Meryem -- Kayatas, Mansur] Cumhuriyet Univ, Div Nephrol, Dept Internal Med, Fac Med, Sivas, Turkey -- [Bagci, Gokhan -- Sezgin, Ilhan] Cumhuriyet Univ, Dept Med Genet, Fac Med, Sivas, Turkey -- [Yilmaz, Ali -- Gedikli, Asim] Cumhuriyet Univ, Dept Internal Med, Fac Med, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Dept Nutr & Dietet, Fac Hlth Sci, Sivas, Turkey
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Biopsy, DNA Mutational Analysis, 030232 urology & nephrology, Familial Mediterranean fever, Gene mutation, Gastroenterology, Nephropathy, Young Adult, 03 medical and health sciences, FMF, Glomerulonephritis, 0302 clinical medicine, Focal segmental glomerulosclerosis, Gene Frequency, Rheumatology, Internal medicine, medicine, Humans, Minimal change disease, MEFV mutation, Aged, Retrospective Studies, 030203 arthritis & rheumatology, business.industry, General Medicine, Middle Aged, Pyrin, medicine.disease, MEFV, Phenotype, Mutation, Immunology, Mesangial proliferative glomerulonephritis, Female, business
Abstract: WOS: 000412950500025, PubMed ID: 28573371, Primary glomerulopathies are those disorders that affect glomerular structure, function, or both in the absence of a multisystem disorder. We aimed to evaluate the frequency of MEFV gene mutation to show possible coexistence of FMF in patients diagnosed with biopsy-proven primary glomerulonephritis (GN). A total of 64 patients with biopsy-proven primary GN were included in the study. MEFV gene mutations examined retrospectively. The mean age of patients was 39.6 +/- 13.4 (range 18-69), 35 of patients were female and 29 of patients were male. Of the 64 patients, 17 were mesangial proliferative glomerulonephritis (MsPGN), 15 were IgA nephropathy (IgAN), 12 were membranous glomerulonephritis (MGN), 11 were focal segmental glomerulosclerosis (FSGS), three were membranous proliferative glomerulonephritis (MPGN), three were immune complex glomerulonephritis (ICGN), two were minimal change disease (MCD), and one was IgM nephropathy (IgMN). MEFV gene mutation was detected in 35.9% (23) of these patients. The most frequently detected mutations were E148Q and M694V. Twelve cases (18.75% of GN patients) with MEFV gene mutation were diagnosed as FMF phenotype I. The frequency of MEFV gene mutation was detected at a high rate of 35.9%. Further studies with larger populations are needed to clarify the importance of these mutations on clinical progression of glomerulonephritis.
Published: 2017

49. Hemorheological parameters in patients with fibromyalgia syndrome

Author: Gokhan Caglayan, Sibel Bayrak, Neslihan Dikmenoglu Falkmarken, Okan Arihan, Ayşen Akıncı, and [Arihan, Okan] Yuzuncu Yil Univ, Fac Med, Dept Physiol, Van, Turkey -- [Caglayan, Gokhan] Cumhuriyet Univ, Fac Med, Dept Phys & Rehabil Med, Div Rheumatol, Sivas, Turkey -- [Bayrak, Sibel -- Falkmarken, Neslihan Dikmenoglu] Hacettepe Univ, Fac Med, Dept Physiol, Ankara, Turkey -- [Akinci, Aysen] Hacettepe Univ, Fac Med, Dept Phys & Rehabil Med, Ankara, Turkey
Subjects: Adult, Erythrocyte Aggregation, Male, musculoskeletal diseases, erythrocyte deformability, medicine.medical_specialty, Fibromyalgia, Physiology, Blood viscosity, 030204 cardiovascular system & hematology, Fibrinogen, Gastroenterology, Erythrocyte aggregation, 03 medical and health sciences, 0302 clinical medicine, Erythrocyte Deformability, Physiology (medical), Internal medicine, medicine, Humans, Erythrocyte deformability, hemorheology, reproductive and urinary physiology, 030203 arthritis & rheumatology, medicine.diagnostic_test, business.industry, Albumin, Complete blood count, hemic and immune systems, Syndrome, Hematology, Middle Aged, Blood Viscosity, biological factors, Hemorheology, embryonic structures, blood viscosity, Female, plasma viscosity, fibromyalgia, erythrocyte, Cardiology and Cardiovascular Medicine, Lipid profile, business, medicine.drug
Abstract: WOS: 000400599300001, PubMed ID: 27814281, AIM: To evaluate hemorheological parameters in patients with fibromyalgia syndrome (FMS) in order to elucidate the etiology of the disease. METHODS: Twenty-three adult FMS patients and 20 healthy controls were enrolled in the study. Diabetics, hypertensives and those with any rheumatological disorder or use drugs or smoking cigarette were excluded from the study. Following parameters were analyzed in each subject; erythrocyte deformability, erythrocyte aggregation, plasma viscosity, complete blood count, fasting blood glucose, fibrinogen, albumin, globulin and lipid profile. RESULTS: Erythrocyte elongation indices indicating deformability of erythrocytes were higher in FMS patients (0.564 +/- 0.002 at 16.87mPa and 0.605 +/- 0.002 at 30mPa shear rate) than controls (0.558 +/- 0.001 at 16.87mPa and 0.600 +/- 0.003 at 30mPa shear rate). Erythrocyte aggregation speed was higher in FMS patients (2.1 +/- 0.1 s) than controls (2.3 +/- 0.2 s). Erythrocyte aggregation index was also higher in FMS patients (65.5 +/- 1.3) than controls (62.9 +/- 1.5). Erythrocyte aggregation amplitude and plasma viscosity values were similar in both groups (both p > 0.05). Among the complete blood count and biochemical parameters, only albumin levels were lower in the FM patients than controls (p < 0.05). CONCLUSION: Our results indicate higher erythrocyte deformability and quicker erythrocyte aggregation in FM patients., Hacettepe University Scientific Research Administration, This study was supported by Hacettepe University Scientific Research Administration.
Published: 2017

50. Untargeted LC-HRMS-Based Metabolomics for Searching New Biomarkers of Pancreatic Ductal Adenocarcinoma: A Pilot Study

Author: Sandra Ríos Peces, Olga Genilloud, José Pérez del Palacio, Jose Prados, Consolación Melguizo, Francisca Vicente Pérez, Caridad Díaz Navarro, Cristina Jiménez-Luna, Octavio Caba, Cristina Márquez López, [Rios Peces, Sandra] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Granada, Spain, [Diaz Navarro, Caridad] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Granada, Spain, [Genilloud, Olga] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Granada, Spain, [Vicente Perez, Francisca] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Granada, Spain, [Perez del Palacio, Jose] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Granada, Spain, [Marquez Lopez, Cristina] Fdn Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid, Spain, [Caba, Octavio] Univ Jaen, Dept Hlth Sci, Jaen, Spain, [Caba, Octavio] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada, Spain, [Jimenez-Luna, Cristina] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada, Spain, [Melguizo, Consolacion] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada, Spain, [Carlos Prados, Jose] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada, Spain, [Jimenez-Luna, Cristina] Univ Granada, Dept Anat & Embryol, Fac Med, Granada, Spain, [Melguizo, Consolacion] Univ Granada, Dept Anat & Embryol, Fac Med, Granada, Spain, [Carlos Prados, Jose] Univ Granada, Dept Anat & Embryol, Fac Med, Granada, Spain, [Melguizo, Consolacion] Univ Granada, SAS, Biosanitary Inst Granada Ibs GRANADA, Granada, Spain, [Carlos Prados, Jose] Univ Granada, SAS, Biosanitary Inst Granada Ibs GRANADA, Granada, Spain, Fundacion MEDINA, Merck Sharp & Dohme de Espana S.A./Universidad de Granada/Junta de Andalucia, European Union, and Ministerio de Ciencia e Innovacion
Subjects: Male, Serum, 0301 basic medicine, Oncology, diagnosis, medicine.medical_treatment, pancreatic ductal adenocarcinoma (PDAC), Urine, Biochemistry, Mass Spectrometry, Analytical Chemistry, Platform, Phospholipids, Cancer, Aged, 80 and over, Principal Component Analysis, Chemistry, Middle Aged, Blood, Phospholipases, Metabolome, biomarker, Molecular Medicine, Biomarker (medicine), Female, Carcinoma, Pancreatic Ductal, Biotechnology, Adult, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, 03 medical and health sciences, Metabolomics, Internal medicine, Biomarkers, Tumor, medicine, Humans, Diagnostic biomarker, Aged, Chemotherapy, Chromatography, reverse-phase liquid chromatography (RPLC), Case-control study, Metabolite identification, hydrophilic interaction liquid chromatography (HILIC), Serum samples, Pancreatic Neoplasms, Early Diagnosis, 030104 developmental biology, Case-Control Studies, Multivariate Analysis, liquid chromatography-high-resolution mass spectrometry (LC-HRMS), liquid chromatography–high-resolution mass spectrometry (LC-HRMS), Chromatography, Liquid
Abstract: Pancreatic ductal adenocarcinoma is one of the most lethal tumors since it is usually detected at an advanced stage in which surgery and/or current chemotherapy have limited efficacy. The lack of sensitive and specific markers for diagnosis leads to a dismal prognosis. The purpose of this study is to identify metabolites in serum of pancreatic ductal adenocarcinoma patients that could be used as diagnostic biomarkers of this pathology. We used liquid chromatography-high-resolution mass spectrometry for a nontargeted metabolomics approach with serum samples from 28 individuals, including 16 patients with pancreatic ductal adenocarcinoma and 12 healthy controls. Multivariate statistical analysis, which included principal component analysis and partial least squares, revealed clear separation between the patient and control groups analyzed by liquid chromatography-high-resolution mass spectrometry using a nontargeted metabolomics approach. The metabolic analysis showed significantly lower levels of phospholipids in the serum from patients with pancreatic ductal adenocarcinoma compared with serum from controls. Our results suggest that the liquid chromatography-high-resolution mass spectrometry-based metabolomics approach provides a potent and promising tool for the diagnosis of pancreatic ductal adenocarcinoma patients using the specific metabolites identified as novel biomarkers that could be used for an earlier detection and treatment of these patients.
Published: 2017

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