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Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease
- Source :
- The Korean Journal of Internal Medicine, Vol 34, Iss 1, Pp 108-115 (2019), The Korean Journal of Internal Medicine
- Publication Year :
- 2019
- Publisher :
- The Korean Association of Internal Medicine, 2019.
-
Abstract
- WOS: 000454539700011<br />PubMed ID: 30428648<br />Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively. Nearly 25% of patients with COPD die due to cardiovascular diseases. In this study, we aimed to evaluate the relationship between the blood pressure, inflammation, hypoxia, hypercapnia, and the severity of airway obstruction. Methods: We included 75 COPD patients in the study with 45 control cases. We evaluated age, sex, body mass index, smoking history, C-reactive protein levels, 24-hour ambulatory blood pressure Holter monitoring, arterial blood gas, and respiratory function tests of the patient and the control groups. Results: In COPD patients, the night time systolic, diastolic blood pressures and pulse per minute and the mean blood pressures readings were significantly elevated compared to the control group (p < 0.05). In the correlation analysis, night time systolic pressure was associated with all the parameters except forced expiratory volume in 1 second (FEV1%). Diastolic blood pressure was associated with pH and HCO3 levels. The mean night time, day time pulse pressures and 24-hour pulse per minute values were also associated with all the parameters except FEV1%. Conclusions: In this study we found that parameters of systolic and diastolic blood pressures and pulse pressures were significantly elevated in COPD patients compared to the control groups. Blood pressure was associated blood gas parameters and inflammation parameters in COPD patients. This, in turn, may cause understanding of the pathophysiology of COPD and its complications.
- Subjects :
- Male
Spirometry
Pulmonology
media_common.quotation_subject
Pulmonary disease
Context (language use)
03 medical and health sciences
0302 clinical medicine
Heart Rate
Forced Expiratory Volume
Economic history
medicine
Humans
Hypoxia
Aged
media_common
Inflammation
medicine.diagnostic_test
chronic obstructive
business.industry
hypoxia
Empire
blood pressure
Islam
Carbon Dioxide
Hydrogen-Ion Concentration
Middle Aged
respiratory tract diseases
Oxygen
Bicarbonates
C-Reactive Protein
Blood pressure
inflammation
Case-Control Studies
Islamization
Medicine
Original Article
Female
030211 gastroenterology & hepatology
pulmonary disease, chronic obstructive
Inflammation Mediators
Apostasy
business
Subjects
Details
- Language :
- English
- ISSN :
- 20056648 and 12263303
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Korean Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....6f3024d0bc3141b3215e9452f3964610