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Resume Introduction La drepanocytose est la premiere maladie genetique en Ile-de-France. L’accident vasculaire cerebral est l’une des complications la plus severe de cette maladie. Chez l’enfant drepanocytaire SS, le Doppler transcrânien (DTC) est, par le biais de l’etude des vitesses moyennes des arteres de la base du crâne, le « gold standard » pour le depistage et le diagnostic de vasculopathie. A notre connaissance, chez l’adulte drepanocytaire, aucune norme concernant les vitesses des arteres de la base du crâne, n’a ete etablie. Il nous est donc apparu utile d’etablir une approche des vitesses cerebrales enregistrees chez les adultes drepanocytaires SS sans complication neurovasculaire. Materiel et methodes Il s’agit d’une etude observationnelle, prospective, monocentrique realisee entre fevrier 2017 et juin 2017. L’objectif principal de l’etude etant de determiner la moyenne et l’ecart-type des vitesses systoliques maximales (VSM) et les moyennes des vitesses maximales pour l’ensemble des arteres enregistrees lors de l’echo Doppler transcrânien. Les objectifs secondaires etant, d’une part, de comparer les moyennes des vitesses systoliques maximales chez l’adulte drepanocytaire a celles de l’adulte sain, ainsi qu'a celles des enfants drepanocytaires, , d’autre part, de determiner si des parametres pouvaient influencer sur les vitesses enregistrees au DTC. Resultats Quarante patients ont ete inclus entre le 1er fevrier 2017 et le 30 juin 2017, avec un âge moyen de 39,3 ans. La moyenne des vitesses maximales au niveau des arteres est de : 78 cm/s pour les arteres cerebrales moyennes ; 59,6 cm/s pour les arteres carotides internes ; 61 cm/s pour les arteres cerebrales anterieures ; 44 cm/s pour les arteres cerebrales posterieures et de 55 cm/s pour le tronc basilaire. Discussion Les vitesses circulatoires les plus elevees sont retrouvees au niveau des arteres cerebrales moyennes. Les vitesses retrouvees au niveau des arteres carotides internes et des arteres cerebrales anterieures sont superieures aux vitesses du systeme vertebrobasilaire. Les vitesses chez l’adulte drepanocytaire sont plus basses que celles decrites chez l’enfant drepanocytaire SS, mais sont significativement plus elevees par rapport aux vitesses retrouvees chez l’adulte sain. Conclusion Cette etude est a notre connaissance la premiere evaluant les vitesses circulatoires au Doppler transcrânien chez l’adulte drepanocytaire. Ce travail presente des limites du fait de son faible echantillon, cependant, elle constitue une base pour les etudes ulterieures concernant le Doppler transcrânien chez l’adulte drepanocytaire.

Sickle cell disease is the leading genetic disease in Île-de-France. Stroke is one of its most severe complications. In SS sickle cell children, transcranial Doppler (TDC) is, through the study of average speeds of the skull base arteries, the gold standard for screening and diagnosis of vasculopathy. To our knowledge, in adults with sickle cell disease, no standards have been established for the speed of the arteries at the base of the skull. It therefore seemed useful to us to establish an approach to brain speeds recorded in adults with sickle cell disorders without neurovascular complications.This was an observational, prospective, monocentric study conducted between February 2017 and June 2017. The main objective of the study was to determine the mean and standard deviation of maximum systolic velocities (MSS) and mean maximum velocities for all arteries recorded during the transcranial Doppler echo. The secondary objectives were to compare the mean maximum systolic velocities in sickle cell adults with those of healthy adults, to compare the mean maximum systolic velocities in sickle cell adults with those of sickle cell children, and to determine whether parameters could influence the speeds recorded at TCD.Forty patients were included between February 1, 2017 and June 30, 2017, with an average age of 39.3 years. The mean maximum velocities recorded were: 78cm/s for the middle cerebral arteries; 59.6cm/s for the internal carotid arteries; 61cm/s for the anterior cerebral arteries; 44cm/s for the posterior cerebral arteries and 55cm/s for the basilar trunk.The highest circulatory velocities are found in the middle cerebral arteries. The speeds found in the internal carotid arteries and anterior cerebral arteries are faster than in the vertebrobasilar system. Speeds in sickle cell adults are slower than those described in sickle cell children SS but significantly faster than those found in healthy adults.To our knowledge, this study is the first to evaluate transcranial Doppler circulatory velocities in adult sickle cell patients. This work has limitations due to its small sample size, however, it provides a basis for further studies on transcranial Doppler in sickle cell adults.

We present results of the detailed dust energy balance study for the seven large edge-on galaxies in the HEROES sample using 3D radiative transfer (RT) modelling. Based on available optical and near-infrared observations of the HEROES galaxies, we derive the 3D distribution of stars and dust in these galaxies. For the sake of uniformity, we apply the same technique to retrieve galaxy properties for the entire sample: we use a stellar model consisting of a S\'ersic bulge and three double-exponential discs (a superthin disc for a young stellar population and thin and thick discs for old populations). For the dust component, we adopt a double-exponential disc with the new THEMIS dust-grain model. We fit oligochromatic radiative transfer (RT) models to the optical and near-infrared images with the fitting algorithm FitSKIRT and do panchromatic simulations with the SKIRT code at wavelengths ranging from ultraviolet to submillimeter. We confirm the previously stated dust energy balance problem in galaxies: for the HEROES galaxies, the dust emission derived from our RT calculations underestimates the real observations by a factor 1.5-4 for all galaxies except NGC 973 and NGC 5907 (apparently, the latter galaxy has a more complex geometry than we used). The comparison between our RT simulations and the observations at mid-infrared-submillimeter wavelengths shows that most of our galaxies exhibit complex dust morphologies (possible spiral arms, star-forming regions, more extended dust structure in the radial and vertical directions). We suggest that, in agreement with the results from Saftly et al. (2015), the large- and small-scale structure is the most probable explanation for the dust energy balance problem., Comment: 53 pages, 31 figures, Accepted for publication in Astronomy & Astrophysics

Locked coil strands can be used in all types of rope supported bridges where long-term corrosion protection is a primary requirement. This paper reports advances of corrosion protection of locked coil strands with galvanically protective coatings and high density polyethylene (HDPE) sheathing.

Recent cosmological hydrodynamical simulations suggest that baryonic processes, and in particular supernova feedback after bursts of star formation, can alter the structure of dark matter haloes and transform primordial cusps into shallower cores. To assess whether this mechanism offers a solution to the cusp-core controversy, simulated haloes must be compared to real dark matter haloes inferred from galaxy rotation curves. For this purpose, two new dark matter density profiles were recently derived from simulations of galaxies in complementary mass ranges: the DC14 halo ($10^{10} < M_{\text{halo}}/M_{\odot} < 8 \times 10^{11}$) and the coreNFW halo ($10^{7} < M_{\text{halo}}/M_{\odot} < 10^{9}$). Both models have individually been found to give good fits to observed rotation curves. For the DC14 model, however, the agreement of the predicted halo properties with cosmological scaling relations was confirmed by one study, but strongly refuted by another. A next question is whether the two models converge to the same solution in the mass range where both should be appropriate. To investigate this, we tested the DC14 and cNFW halo models on the rotation curves of a selection of galaxies with halo masses in the range $4 \times 10^{9}$ - $7 \times 10^{10}$ $M_{\odot}$. We further applied the DC14 model to a set of rotation curves at higher halo masses, up to $9 \times 10^{11}$ $M_{\odot}$, to verify the agreement with the cosmological scaling relations. We find that both models are generally able to reproduce the observed rotation curves, in line with earlier results, and the predicted dark matter haloes are consistent with the cosmological $c-M_{\text{halo}}$ and $M_{*}-M_{\text{halo}}$ relations. The DC14 and cNFW models are also in fairly good agreement with each other, even though DC14 tends to predict slightly less extended cores and somewhat more concentrated haloes than cNFW., Comment: 19 pages, 12 figures, accepted for publication in A&A

Resume L’insomnie ne peut pas etre consideree uniquement comme un trouble du sommeil car elle entraine des consequences diurnes parfois tres importantes. Ces consequences touchent differents domaines : vie sociale, loisirs, activite professionnelle. Depuis quelques annees, ces repercussions diurnes font partie integrante de la definition de l’insomnie et servent meme parfois a en quantifier la severite. L’un des objectifs de l’etude suivante a ete de mieux connaitre le point de vue des medecins generalists en ce qui concerne les consequences de l’insomnie et notamment leurs repercussions socioprofessionnelles.

Context. Edge-on galaxies can offer important insights in galaxy evolution as they are the only systems where the distribution of the different components can be studied both radially and vertically. The HEROES project was designed to investigate the interplay between the gas, dust, stars and dark matter (DM) in a sample of 7 massive edge-on spiral galaxies. Aims. In this second HEROES paper we present an analysis of the atomic gas content of 6 out of 7 galaxies in our sample. The remaining galaxy was recently analysed according to the same strategy. The primary aim of this work is to constrain the surface density distribution, the rotation curve and the geometry of the gas disks in a homogeneous way. In addition we identify peculiar features and signs of recent interactions. Methods. We construct detailed tilted-ring models of the atomic gas disks based on new GMRT 21-cm observations of NGC 973 and UGC 4277 and re-reduced archival HI data of NGC 5907, NGC 5529, IC 2531 and NGC 4217. Potential degeneracies between different models are resolved by requiring a good agreement with the data in various representations of the data cubes. Results. From our modelling we find that all but one galaxy are warped along the major axis. In addition, we identify warps along the line of sight in three galaxies. A flaring gas layer is required to reproduce the data only for one galaxy, but (moderate) flares cannot be ruled for the other galaxies either. A coplanar ring-like structure is detected outside the main disk of NGC 4217, which we suggest could be the remnant of a recent minor merger event. We also find evidence for a radial inflow of 15 +- 5 km/s in the disk of NGC 5529, which might be related to the ongoing interaction with two nearby companions. (Abridged), 39 pages, 38 figures, Accepted for publication in Astronomy & Astrophysics

The rates of pregnant women with functional symptoms of venous insufficiency who accepted or refused to wear therapeutic compression stockings were evaluated and compared in relation to their clinical evolution and their compliance levels.The observational study was conducted in pregnant women between 4 and 28 weeks of amenorrhea presenting a CEAP C0S to C3S venous disease. Therapeutic compression stockings (BSN medical, UltraSheer Maternity stockings, 15-20 mmHg) were offered to pregnant women satisfying the inclusion criteria during routine check visits, and both groups of patients (those who accepted as well as those who refused) were followed up until the end of the pregnancy. The clinical profiles of both groups and the evolution of the venous insufficiency were monitored and compared. The women were requested to indicate pain and further quality of life parameter by means of a specific questionnaire (CIVIQ).Ninety-eight women were included in the study and followed up; 30.6% (N.=30) of the women refused to wear compression stockings (Wr), 69.4% accepted 10.6% were not compliant to a daily wear (Wanc) and 58.8% wore them every day (Wac). Leg pain was more prominent in case of the Wac group (49.5 ± 21.3) than in case of the Wanc (42.1 ± 20.4) and Wr groups (36.6 ± 18). Their global quality also decreased (48.8 ± 15.7 vs. 43.6 ± 16.1 and 36.6 ± 15.6). Regular use of compression stockings led to decrease of pain (Wac -17 ± 10.1 vs. Wanc -10.3 ± 10.5 vs. Wr -4.2 ± 9.8 [P0.0001]) and enhanced total quality of life (Wac 13.5 ± 9.6 vs. Wanc 10.7 ± 11.3 vs. Wr -3.3 ± 9.4 [P0.0001). Similar results were observed on the CIVIQ subscale (pain, psychological, social, physical impact of legs' pain on women quality of life).In daily practice, more than two third of the pregnant women accepted to wear compression stockings. The use of compression stockings reduced the legs pain and increased the quality of life of pregnant women.

M. Baes et al., We cross-correlate the Planck Catalogue of Compact Sources (PCCS) with the fully sampled 84 deg2Herschel Virgo Cluster Survey (HeViCS) fields. We search for and identify the 857 and 545 GHz PCCS sources in the HeViCS fields by studying their FIR/submm and optical counterparts. We find 84 and 48 compact Planck sources in the HeViCS fields at 857 and 545 GHz, respectively. Almost all sources correspond to individual bright Virgo Cluster galaxies. The vast majority of the Planck detected galaxies are late-type spirals, with the Sc class dominating the numbers, while early-type galaxies are virtually absent from the sample, especially at 545 GHz. We compare the HeViCS SPIRE flux densities for the detected galaxies with the four different PCCS flux density estimators and find an excellent correlation with the aperture photometry flux densities, even at the highest flux density levels. We find only seven PCCS sources in the HeViCS fields without a nearby galaxy as obvious counterpart, and conclude that all of these are dominated by Galactic cirrus features or are spurious detections. No Planck sources in the HeViCS fields seem to be associated to high-redshift proto-clusters of dusty galaxies or strongly lensed submm sources. Finally, our study is the first empirical confirmation of the simulation-based estimated completeness of the PCCS, and provides a strong support of the internal PCCS validation procedure. © 2014 ESO., M.B., J.F. and T.H. acknowledge financial support from the Belgian Science Policy Office (BELSPO) through the PRODEX project “Herschel-PACS Guaranteed Time and Open Time Programs: Science Exploitation” (C90370). M.C. and G.D.Z. acknowledge financial support from ASI/INAF Agreement I/072/09/0. M.B., F.A., I.D.L., G.G., S.V. and J.V. acknowledge support from the Flemish Fund for Scientific Research (FWO-Vlaanderen). SPIRE has been developed by a consortium of institutes led by Cardiff University (UK) and including Univ. Lethbridge (Canada); NAOC (China); CEA, LAM (France); IFSI, Univ. Padua (Italy); IAC (Spain); Stockholm Observatory (Sweden); Imperial College London, RAL, UCLMSSL, UKATC, Univ. Sussex (UK); and Caltech, JPL, NHSC, Univ. Colorado (USA). This development has been supported by national funding agencies: CSA (Canada); NAOC (China); CEA, CNES, CNRS (France); ASI (Italy); MCINN (Spain); SNSB (Sweden); STFC (UK); and NASA (USA). The development of Planck has been supported by: ESA; CNES and CNRS/INSU-IN2P3-INP (France); ASI, CNR, and INAF (Italy); NASA and DoE (USA); STFC and UKSA (UK); CSIC, MICINN and JA (Spain); Tekes, AoF and CSC (Finland); DLR and MPG (Germany); CSA (Canada); DTU Space (Denmark); SER/SSO (Switzerland); RCN (Norway); SFI (Ireland); FCT/MCTES (Portugal); and PRACE (EU). Funding for the SDSS and SDSS-II has been provided by the Alfred P. Sloan Foundation, the Participating Institutions, the National Science Foundation, the US Department of Energy, the National Aeronautics and Space Administration, the Japanese Monbukagakusho, the Max Planck Society, and the Higher Education Funding Council for England.

We investigate the connection between dust and gas in the nearby edge-on spiral galaxy NGC 891. High resolution Herschel PACS and SPIRE 70, 100, 160, 250, 350, and 500 $\mu$m images are combined with JCMT SCUBA 850 $\mu$m observations to trace the far-infrared/submillimetre spectral energy distribution (SED). Maps of the HI 21 cm line and CO(J=3-2) emission trace the atomic and molecular hydrogen gas, respectively. We fit one-component modified blackbody models to the integrated SED, finding a global dust mass of 8.5$\times$10$^{7}$ M$_{\odot}$ and an average temperature of 23$\pm$2 K. We also fit the pixel-by-pixel SEDs to produce maps of the dust mass and temperature. The dust mass distribution correlates with the total stellar population as traced by the 3.6 $\mu$m emission. The derived dust temperature, which ranges from approximately 17 to 24 K, is found to correlate with the 24 $\mu$m emission. Allowing the dust emissivity index to vary, we find an average value of $\beta$ = 1.9$\pm$0.3. We confirm an inverse relation between the dust emissivity spectral index and dust temperature, but do not observe any variation of this relationship with vertical height from the mid-plane of the disk. A comparison of the dust properties with the gaseous components of the ISM reveals strong spatial correlations between the surface mass densities of dust and the molecular hydrogen and total gas surface densities. Observed asymmetries in the dust temperature, and the H$_{2}$-to-dust and total gas-to-dust ratios hint that an enhancement in the star formation rate may be the result of larger quantities of molecular gas available to fuel star formation in the NE compared to the SW. Whilst the asymmetry likely arises from dust obscuration due to the geometry of the line-of-sight projection of the spiral arms, we cannot exclude an enhancement in the star formation rate in the NE side of the disk., Comment: Accepted for publication in A&A. 21 pages, including 13 figures and 4 tables

Context. Edge-on spiral galaxies with prominent dust lanes provide us with an excellent opportunity to study the distribution and properties of the dust within them. The HEROES project was set up to observe a sample of seven large edge-on galaxies across various wavelengths for this investigation. Aims. Within this first paper, we present the Herschel observations and perform a qualitative and quantitative analysis on them, and we derive some global properties of the far infrared and submillimetre emission. Methods. We determine horizontal and vertical profiles from the Herschel observations of the galaxies in the sample and describe the morphology. Modified black-body fits to the global fluxes, measured using aperture photometry, result in dust temperatures and dust masses. The latter values are compared to those that are derived from radiative transfer models taken from the literature. Results. On the whole, our Herschel flux measurements agree well with archival values. We find that the exponential horizontal dust distribution model often used in the literature generally provides a good description of the observed horizontal profiles. Three out of the seven galaxies show signatures of extended vertical emission at 100 and 160 {\mu}m at the 5{\sigma} level, but in two of these it is probably due to deviations from an exactly edge-on orientation. Only for NGC 4013, a galaxy in which vertically extended dust has already been detected in optical images, we can detect vertically extended dust, and the derived scaleheight agrees with the value estimated through radiative transfer modelling. Our analysis hints at a correlation between the dust scaleheight and its degree of clumpiness, which we infer from the difference between the dust masses as calculated from modelling of optical data and from fitting the spectral energy distribution of Herschel datapoints., Comment: 21 pages, 12 figures. Accepted for publication in Astronomy & Astrophysics

We investigate the dust energy balance for the edge-on galaxy IC 2531, one of the seven galaxies in the HEROES sample. We perform a state-of-the-art radiative transfer modelling based, for the first time, on a set of optical and near-infrared galaxy images. We show that taking into account near-infrared imaging in the modelling significantly improves the constraints on the retrieved parameters of the dust content. We confirm the result from previous studies that including a young stellar population in the modelling is important for explaining the observed stellar energy distribution. However, the discrepancy between the observed and modelled thermal emission at far-infrared wavelengths, the so-called dust energy balance problem, is still present: the model underestimates the observed fluxes by a factor of about two. We compare two different dust models, and find that dust parameters and thus the spectral energy distribution in the infrared domain are sensitive to the adopted dust model. In general, the THEMIS model reproduces the observed emission in the infrared wavelength domain better than the popular Zubko et al. BARE-GR-S model. Our study of IC 2531 is a pilot case for detailed and uniform radiative transfer modelling of the entire HEROES sample, which will shed more light on the strength and origins of the dust energy balance problem., Comment: 15 pages, 8 figures, Accepted for publication in Astronomy & Astrophysics

The largest-to-date randomized trial (Women's Health Initiative) comparing the effects of hormone replacement therapy (HRT) and a placebo concluded that the continuous use of an oral combination of conjugated equine estrogens (CEE) and medroxy-progesterone acetate (MPA) increases the risk of breast cancer. This conclusion may not apply to women taking other estrogen and progestin formulations, as suggested by discrepancies in the findings of in vitro studies, epidemiological surveys and, mostly, in vivo studies of human breast epithelial cell proliferation showing opposite effects of HRT combining CEE plus MPA or estradiol plus progesterone. To evaluate the risk of breast cancer associated with the use of the latter combination, commonly prescribed in France, a cohort including 3175 postmenopausal women was followed for a mean of 8.9 years (28 367 woman-years). In total, 1739 (55%) of these women were users of one type of estrogen replacement with systemic effect during at least 12 months, any time after the menopause, and were classified as HRT users. Among them, 83% were receiving exclusively or mostly a combination of a transdermal estradiol gel and a progestin other than MPA. Some 105 cases of breast cancer occurred during the follow-up period, corresponding to a mean of 37 new cases per 10 000 women/year. Using multivariate analysis adjusted for the calendar period of treatment, date of birth and age at menopause, we were unable to detect an increase in the relative risk (RR) of breast cancer (RR 0.98, 95% confidence interval (CI): 0.65-1.5) in the HRT users. The RR of breast cancer per year of use of HRT was 1.005 (95% CI 0.97-1.05). These results do not justify early interruption of such a type of HRT, which is beneficial for quality of life, prevention of bone loss and cardiovascular risk profile, without the activation of coagulation and inflammatory protein synthesis measured in users of oral estrogens.

The aim of this observational study in patients with chronic hepatitis C and treated with interferon alpha-2a was to assess 1) monitoring in everyday practice, 2) the acceptability of treatment and 3) the intensity of fatigue.Three hundred and fifty four patients were enrolled by physicians in both teaching and general hospitals, or private practice. Before treatment, clinical, epidemiological, and virological data were collected as well as a self-evaluation of fatigue using a visual analogic scale. Clinical follow-up was assessed every 3 months during treatment and 6 months after the end of treatment and included an evaluation of fatigue and the number of workdays missed due to sickness.Two hundred and nineteen men and 135 women, mean age 45 +/- 13, were included. The epidemiological, histological and virological features of this group were similar to those patients usually treated for chronic hepatitis C. Before treatment, the mean measurement of fatigue was 41 on a scale from 0 (perfect form) to 100 (exhausted). Fatigue was unrelated to age, source of infection, biological activity, or histological score. It worsened in patients who stopped interferon after 3 or 6 months, but was stable in patients who continued treatment for 12 months. Fatigue decreased after the end of treatment and was unrelated to treatment response. The need to stop work was strongly related to the intensity of fatigue and the number of workdays missed due to sickness represented nearly two months out of three in 25% of active patients during the first quarter and in 15% of patients thereafter. 61% of patients self-injected interferon (mainly previous drug users) whereas 30% of patients used nurse care throughout treatment.This study not only provides a realistic evaluation of fatigue in patients with chronic hepatitis C, before, during and after treatment, but also highlights its social and economic consequences. It shows the need for further cost-effectiveness studies on new therapeutic strategies using combined treatments.

Low back pain (LBP)-related disability involves patients with chronic outcome.To identify the factors predictive of chronic evolution of acute LBP and to develop a predictive clinical index.Prospective investigation of 2487 employed patients referred for their first consultation with acute LBP (less than eight days). Chronic evolution defined by persistence of symptoms, unchanged or worse, at seven weeks. A predictive index was developed according to a logistic regression model.One hundred fifty-five patients (6.2%) were considered to have unchanged or worsened LBP at the time of final evaluation, which was carried out on average 42 +/- 15 days after the initial visit, and were thus regarded as having a chronic outcome. When comparing patients with chronic outcome and the others, there were 25 elementary characteristics for which the degree of significance of the bilateral test was less than 0.01. They were introduced into a logistic regression model. Five parameters appeared to be related to chronic outcome: characteristics of current episode (isolated acute low back pain, acute exacerbation of chronic low back pain, sciatica), two daily living activity items, duration of certificate to remain off work and taking part in a sport. They were used to develop an easily applied index providing identification, as of the initial consultation, of the risk of chronic evolution.The early recognition of patients with LBP with high risk of chronic outcome can be achieved with an easily applied clinical index.

The prevalence of pressure ulcers in hospitals in France is given, and the anatomical location of these ulcers is explored. The importance of establishing accurate stages for these wounds is also emphasized. Four methods of cost-effectiveness analysis are proposed and described: analysis of one case; analysis of one ward; analysis of care time; and analysis of one tetraplegic young man.

The authors used a prospective study of 309 great saphenous veins to analyse, by Doppler and ultrasonography, the mechanism of sclerosis following sclerosing injections. These were administered at a maximum of 50mm from the sapheno-femoral junction using a protocol based upon five sessions. It was found possible to establish a close relationship between the quality of results and small calibre. Similarly, recurrence by early repermeation was generally secondary to a sclerosing reaction having caused thrombosis. Other changes were seen during or at the end of treatment, sometimes differing greatly from clinical findings. This type of sclerosing injection therapy provided more than 90% favourable responses to treatment after a follow-up period of 15.7 months. Analysis of other parameters may possibly enable even better definition of the treatment of this condition and its natural history.

Introduction et but de l’etude La population âgee denutrie est exposee a un grand risque de morbidite et de mortalite. Le but de cette etude etait de decrire l’evolution du profil clinique des sujets âges denutris, apres un suivi d’un an, en fonction des modalites de prise en charge de la denutrition. Materiel et methodes Etude observationnelle prospective d’une cohorte de sujets âges denutris (MNA au depistage Resultats 806 sujets âges de 85,4± 6 ans ont ete inclus dans cette cohorte. Majoritairement des femmes (73,3 %), 78,3 % etaient atteints d’une affection de longue duree. A l’inclusion, l’etat nutritionnel etait decrit par : le poids moyen de 54 ± 10,9 kg, l’IMC a 23 chez 8,7 %, une denutrition (MNA Seuls 29,2 % des patients recevaient un traitement anterieur de la denutrition, et 10,4 % ne recevaient aucune prise en charge nutritionnelle apres la visite d’inclusion. 72,7 % des patients ont recu un traitement adjuvant pendant le suivi : 32 % pendant 1 a 3 mois, 23,1 % pendant 3 a 6 mois et 17,8 % pendant 6 mois et plus. Une prise de poids a ete constatee chez 45,3 % d’entre eux, significative chez les moins de 85 ans (OR = 1,94 ; IC95 % = 1,34-2,8, p Conclusions L’effet de la prise en charge de la denutrition des personnes âgees et de sa duree ont ete evalues dans cette etude : l’etat nutritionnel et cognitif se sont ameliores chez les personnes de moins de 85 ans et traitees pendant au moins 6 mois.