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2 results on '"Extracellular matrix and inflammation"'

1. A role for leukocyte integrins and extracellular matrix remodeling of adipose tissue in the risk of weight regain after weight loss.

Author

Roumans, Nadia J. T., Vink, Roel G., Fazelzadeh, Parastoo, van Baak, Marleen A., and Mariman, Edwin C. M.

Subjects
EXTRACELLULAR matrix, WEIGHT loss, ADIPOSE tissues, GENE expression, WEIGHT gain, GENETICS, PHYSIOLOGY, REDUCING diets, WEIGHT gain risk factors, CELL receptors, CLINICAL trials, EXTRACELLULAR space, GENES, INSULIN resistance, LEUCOCYTES, LONGITUDINAL method, NUTRITION, PROBABILITY theory, STATISTICAL sampling, GENOMICS, RANDOMIZED controlled trials, PRE-tests & post-tests, MICROARRAY technology, DESCRIPTIVE statistics, ABDOMINAL adipose tissue
Abstract

Background: Weight loss (WL) is often followed by weight regain after an energy-restricted dietary intervention (DI). When people are following a diet, the volume of an adipocyte decreases by loss of triglycerides, which creates stress between the cell contents and the surrounding extracellular matrix (ECM). Previously, we observed that genetic variations in ECM genes are associated with an increased risk of weight regain. Objective: We investigated the relation between the expression of ECM genes during WL and a period of weight stabilization (WS) and the risk of weight regain. Design: In this randomized controlled trial, 61 healthy overweight or obese participants followed either a 5-wk very-low-calorie diet (VLCD; 500 kcal/d) or a 12-wk low-calorie diet (1250 kcal/d) (WL period) with a subsequent 4-wk WS period and a 9-mo follow-up. The WL and WS periods combined were considered the DI. Abdominal subcutaneous adipose tissue biopsy samples were collected for microarray analysis. Gene expression changes for a broad set of ECM-related genes were correlated with the weight-regain percentage (WR%). Results: A total of 26 of the 277 genes were significantly correlated with WR% during WL, WS, or the DI periods. Most correlations were observed in the VLCD group during the WS period. Four genes code for leukocyte-specific receptors. These and other genes belong to a group of 26 genes, among which the expression changes were highly correlated (r ≥ 0.7, P ≤ 0.001). This group could be divided into 3 subclusters linking to 2 biological processes--leukocyte integrin gene activity and ECM remodeling--and a link to insulin sensitivity was also apparent. Conclusions: Our present findings indicate the importance of adipose tissue leukocytes for the risk of weight regain. ECM modification also seems to be involved, and we observed a link to insulin sensitivity. This trial was registered at clinicaltrials.gov as NCT01559415. [ABSTRACT FROM AUTHOR]

Published
2017
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2. A role for leukocyte integrins and extracellular matrix remodeling of adipose tissue in the risk of weight regain after weight loss

Author

Parastoo Fazelzadeh, Edwin C. M. Mariman, Nadia J. T. Roumans, Marleen A. van Baak, Roel G. Vink, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - R4 - Gene-environment interaction, RS: NUTRIM - HB/BW section A, and RS: NUTRIM - R1 - Metabolic Syndrome

Subjects
Male, 0301 basic medicine, Integrins, Human dietary intervention, Gene Expression, Medicine (miscellaneous), Adipose tissue, Microarray, Weight Gain, Body Weight Maintenance, Extracellular matrix, Voeding, Metabolisme en Genomica, chemistry.chemical_compound, 0302 clinical medicine, Weight loss, Adipocyte, Adipocytes, Leukocytes, MACROPHAGES, GENE-EXPRESSION, INSULIN-RESISTANCE, Nutrition and Dietetics, healthy overweight/obese participants, Middle Aged, Metabolism and Genomics, adipose tissue, Extracellular Matrix, Very low calorie diet, Metabolisme en Genomica, DISEASES, Nutrition, Metabolism and Genomics, Female, human dietary intervention, medicine.symptom, microarray, Risk, medicine.medical_specialty, YKL-40, Diet, Reducing, Diet therapy, food.diet, Healthy overweight/obese participants, Weight regain after weight loss, 030209 endocrinology & metabolism, Biology, weight regain after weight loss, 03 medical and health sciences, food, Insulin resistance, Voeding, Extracellular matrix and inflammation, Internal medicine, Weight Loss, medicine, Humans, Obesity, Triglycerides, Nutrition, Caloric Restriction, OVERWEIGHT, Body Weight, ADULTS, medicine.disease, Subcutaneous Fat, Abdominal, MAINTENANCE, 030104 developmental biology, Endocrinology, chemistry, Insulin Resistance, Energy Intake, CATHEPSIN-S, extracellular matrix and inflammation
Abstract

Background: Weight loss (WL) is often followed by weight regain after an energy-restricted dietary intervention (DI). When people are following a diet, the volume of an adipocyte decreases by loss of triglycerides, which creates stress between the cell contents and the surrounding extracellular matrix (ECM). Previously, we observed that genetic variations in ECM genes are associated with an increased risk of weight regain. Objective: We investigated the relation between the expression of ECM genes during WL and a period of weight stabilization (WS) and the risk of weight regain. Design: In this randomized controlled trial, 61 healthy overweight or obese participants followed either a 5-wk very-low-calorie diet (VLCD; 500 kcal/d) or a 12-wk low-calorie diet (1250 kcal/d) (WL period) with a subsequent 4-wk WS period and a 9-mo follow-up. The WL and WS periods combined were considered the DI. Abdominal subcutaneous adipose tissue biopsy samples were collected for microarray analysis. Gene expression changes for a broad set of ECM-related genes were correlated with the weight-regain percentage (WR%). Results: A total of 26 of the 277 genes were significantly correlated with WR% during WL, WS, or the DI periods. Most correlations were observed in the VLCD group during the WS period. Four genes code for leukocyte-specific receptors. These and other genes belong to a group of 26 genes, among which the expression changes were highly correlated (r ≥ 0.7, P ≤ 0.001). This group could be divided into 3 subclusters linking to 2 biological processes-leukocyte integrin gene activity and ECM remodeling-and a link to insulin sensitivity was also apparent. Conclusions: Our present findings indicate the importance of adipose tissue leukocytes for the risk of weight regain. ECM modification also seems to be involved, and we observed a link to insulin sensitivity. This trial was registered at clinicaltrials.gov as NCT01559415.

Published
2017

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