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A role for leukocyte integrins and extracellular matrix remodeling of adipose tissue in the risk of weight regain after weight loss
- Source :
- American Journal of Clinical Nutrition 105 (2017) 5, American Journal of Clinical Nutrition, 105(5), 1054-1062. Oxford University Press, American Journal of Clinical Nutrition, 105(5), 1054-1062
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background: Weight loss (WL) is often followed by weight regain after an energy-restricted dietary intervention (DI). When people are following a diet, the volume of an adipocyte decreases by loss of triglycerides, which creates stress between the cell contents and the surrounding extracellular matrix (ECM). Previously, we observed that genetic variations in ECM genes are associated with an increased risk of weight regain. Objective: We investigated the relation between the expression of ECM genes during WL and a period of weight stabilization (WS) and the risk of weight regain. Design: In this randomized controlled trial, 61 healthy overweight or obese participants followed either a 5-wk very-low-calorie diet (VLCD; 500 kcal/d) or a 12-wk low-calorie diet (1250 kcal/d) (WL period) with a subsequent 4-wk WS period and a 9-mo follow-up. The WL and WS periods combined were considered the DI. Abdominal subcutaneous adipose tissue biopsy samples were collected for microarray analysis. Gene expression changes for a broad set of ECM-related genes were correlated with the weight-regain percentage (WR%). Results: A total of 26 of the 277 genes were significantly correlated with WR% during WL, WS, or the DI periods. Most correlations were observed in the VLCD group during the WS period. Four genes code for leukocyte-specific receptors. These and other genes belong to a group of 26 genes, among which the expression changes were highly correlated (r ≥ 0.7, P ≤ 0.001). This group could be divided into 3 subclusters linking to 2 biological processes-leukocyte integrin gene activity and ECM remodeling-and a link to insulin sensitivity was also apparent. Conclusions: Our present findings indicate the importance of adipose tissue leukocytes for the risk of weight regain. ECM modification also seems to be involved, and we observed a link to insulin sensitivity. This trial was registered at clinicaltrials.gov as NCT01559415.
- Subjects :
- Male
0301 basic medicine
Integrins
Human dietary intervention
Gene Expression
Medicine (miscellaneous)
Adipose tissue
Microarray
Weight Gain
Body Weight Maintenance
Extracellular matrix
Voeding, Metabolisme en Genomica
chemistry.chemical_compound
0302 clinical medicine
Weight loss
Adipocyte
Adipocytes
Leukocytes
MACROPHAGES
GENE-EXPRESSION
INSULIN-RESISTANCE
Nutrition and Dietetics
healthy overweight/obese participants
Middle Aged
Metabolism and Genomics
adipose tissue
Extracellular Matrix
Very low calorie diet
Metabolisme en Genomica
DISEASES
Nutrition, Metabolism and Genomics
Female
human dietary intervention
medicine.symptom
microarray
Risk
medicine.medical_specialty
YKL-40
Diet, Reducing
Diet therapy
food.diet
Healthy overweight/obese participants
Weight regain after weight loss
030209 endocrinology & metabolism
Biology
weight regain after weight loss
03 medical and health sciences
food
Insulin resistance
Voeding
Extracellular matrix and inflammation
Internal medicine
Weight Loss
medicine
Humans
Obesity
Triglycerides
Nutrition
Caloric Restriction
OVERWEIGHT
Body Weight
ADULTS
medicine.disease
Subcutaneous Fat, Abdominal
MAINTENANCE
030104 developmental biology
Endocrinology
chemistry
Insulin Resistance
Energy Intake
CATHEPSIN-S
extracellular matrix and inflammation
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....900fca6368db8e48f48bc2787840fdf6