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293 results on '"European Cooperation in Science and Technology (COST)"'

1. Delphi Study on Psychological Safety Competencies in Healthcare Training Curricula

Author: Miguel Hernández University of Elche, European Cooperation in Science and Technology, COST, RheinMain University of Applied Science, University of Tartu, Tartu Health Care College, LAB University of Applied Sciences, University of Haifa, Vilnius university hospital Sanatros klinikos, University of Malta, Universidade Nova de Lisboa, Clinical Hospital Centre Zagreb, Pavol Jozef Safarik University, University of Belgrade, and José Joaquín Mira Solves, Professor
Published: 2023

2. sp2-Iminosugar Azobenzene O-glycosides: Light-sensitive Glycosidase Inhibitors with Unprecedented Tunability and Switching Factors

Author: Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Natural Sciences and Engineering Research Council of Canada (NSERC), Universidad de Sevilla, Rivero Barbarroja, Gonzalo, Padilla Pérez, María del Carmen, Maisonneuve, Stéphane, García Moreno, M. Isabel, Tiet, Ben, Vocadlo, David J., Xie, Juan, García Fernández, José M., Ortiz Mellet, Carmen, Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Natural Sciences and Engineering Research Council of Canada (NSERC), Universidad de Sevilla, Rivero Barbarroja, Gonzalo, Padilla Pérez, María del Carmen, Maisonneuve, Stéphane, García Moreno, M. Isabel, Tiet, Ben, Vocadlo, David J., Xie, Juan, García Fernández, José M., and Ortiz Mellet, Carmen
Published: 2024

3. High-Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC-SIGN and Langerin

Author: Universidad de Sevilla. Departamento de Química orgánica, Agencia Estatal de Investigación. España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), European Cooperation in Science and Technology (COST), Junta de Andalucía, Grenoble Partnership for Structural Biology (PSB). France, French Infrastructure for Integrated Structural Biology (FRISBI). France, Grenoble alliance for integrated structural and cellular biology (GRAL). France, University Grenoble Alpes Graduate School. France, Herrera González, Irene, González Cuesta, Manuel, Thépaut, Michel, Laigre, Eugénie, Goyard, David, Rojo, Javier, García Fernández, José Manuel, Ortiz Mellet, Carmen, Universidad de Sevilla. Departamento de Química orgánica, Agencia Estatal de Investigación. España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), European Cooperation in Science and Technology (COST), Junta de Andalucía, Grenoble Partnership for Structural Biology (PSB). France, French Infrastructure for Integrated Structural Biology (FRISBI). France, Grenoble alliance for integrated structural and cellular biology (GRAL). France, University Grenoble Alpes Graduate School. France, Herrera González, Irene, González Cuesta, Manuel, Thépaut, Michel, Laigre, Eugénie, Goyard, David, Rojo, Javier, García Fernández, José Manuel, and Ortiz Mellet, Carmen
Abstract: The “carbohydrate chemical mimicry” exhibited by sp2-iminosugars has been utilized to develop practical syntheses for analogs of the branched high-mannose-type oligosaccharides (HMOs) Man3 and Man5. In these compounds, the terminal nonreducing Man residues have been substituted with 5,6-oxomethylidenemannonojirimycin (OMJ) motifs. The resulting oligomannoside hemimimetic accurately reproduce the structure, configuration, and conformational behavior of the original mannooligosaccharides, as confirmed by NMR and computational techniques. Binding studies with mannose binding lectins, including concanavalin A, DC-SIGN, and langerin, by enzyme-linked lectin assay and surface plasmon resonance revealed significant variations in their ability to accommodate the OMJ unit in the mannose binding site. Intriguingly, OMJMan segments demonstrated “in line” heteromultivalent effects during binding to the three lectins. Similar to the mannobiose (Man2) branches in HMOs, the binding modes involving the external or internal monosaccharide unit at the carbohydrate binding-domain exist in equilibrium, facilitating sliding and recapture processes. This equilibrium, which influences the multivalent binding of HMOs, can be finely modulated upon incorporation of the OMJ sp2-iminosugar caps. As a proof of concept, the affinity and selectivity towards DC-SIGN and langerin were adjustable by presenting the OMJMan epitope in platforms with diverse architectures and valencies.
Published: 2023

4. Neighbouring Scots pine populations from contrasting climatic regions show substantial variability but consistent response to warming

Author: Universidad de Sevilla. Departamento de Biología Vegetal y Ecología, Universidad de Sevilla. RNM318: Ecología de Sistemas Agrarios, Ganaderos y Forestales, European Cooperation in Science and Technology (COST), Ramón y Cajal, González Díaz, Pedro Antonio, Cavers, S., Matías Resina, Luis, Ennos, R. A., Cottrell, J. E., Jump, A. S., Universidad de Sevilla. Departamento de Biología Vegetal y Ecología, Universidad de Sevilla. RNM318: Ecología de Sistemas Agrarios, Ganaderos y Forestales, European Cooperation in Science and Technology (COST), Ramón y Cajal, González Díaz, Pedro Antonio, Cavers, S., Matías Resina, Luis, Ennos, R. A., Cottrell, J. E., and Jump, A. S.
Abstract: Natural tree populations consist of individuals that exhibit intraspecific adaptive variation at a range of geographic scales, as a result of the balance between gene flow and selection. The spatial distribution and magnitude of such variation will influence the capacity of populations to adapt to forthcoming changing environmental conditions. The native Scots pine populations in Scotland represent what remains of the iconic Caledonian forest. Despite being distributed within a relatively narrow geographic area these populations occur across a steep East-West environmental gradient of increasing rainfall and temperature. We hypothesised that western populations compared to those from the east may be better adapted to warmer conditions and as a consequence, may respond differently to the increased temperature predicted during climate change. We conducted an experiment lasting 22 weeks in controlled environment chambers using a nested hierarchical design based on material from different regions (west or east), populations and families (half sibs). We examined the effects of two temperature scenarios, current temperature and warmer predicted temperature on percentage germination as well as growth and morphology of above and below-ground traits. Most of the variation occurred at the family level. Nevertheless, significant regional and population differences were detected, where eastern populations invested more in roots, exhibited fewer stomatal rows per needle and produced thinner roots. In addition, warmer temperatures had strong effects on early growth that were consistent in material from both regions and resulted in earlier germination, greater growth and biomass, but these effects were not accompanied by shifts in biomass partitioning. Although the strong effect of warming suggested temperature limitation for early growth in the study areas under current conditions our results did not support the idea that low seedling recruitment resulting from poor emergence and
Published: 2023

5. Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands

Author: Universidad de Sevilla. Departamento de Biología Celular, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Junta de Andalucía, Asociación Española Contra el Cáncer, Marie Sklodowska-Curie Individual Fellowship, European Cooperation in Science and Technology (COST), Carrillo Carrión, Carolina, Comaills, Valentine, Visiga, Ana M., Gauthier, Benoit R., Khiar, Noureddine, Universidad de Sevilla. Departamento de Biología Celular, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Junta de Andalucía, Asociación Española Contra el Cáncer, Marie Sklodowska-Curie Individual Fellowship, European Cooperation in Science and Technology (COST), Carrillo Carrión, Carolina, Comaills, Valentine, Visiga, Ana M., Gauthier, Benoit R., and Khiar, Noureddine
Abstract: We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, in the presence of the enzyme alkaline phosphatase (ALP). This unprecedented reactivity was possible thanks to the prior functionalization of the MOF with N3-PEG-PO3 ligands, which were designed for three specific aims: (1) to impart colloidal stability in phosphate-containing media; (2) to endow the MOF with multifunctionality thanks to azide groups for the covalent attachment of an imaging agent by click-chemistry; and (3) to confer stimuli-responsive properties, specifically the selective release of doxorubicin triggered by the enzymatic activity of ALP. Cell studies revealed that the functionalization of the MOF with N3-(PEG)20-PO3 ligands improved their intracellular stability and led to a sustained drug release compared to the bare MOF. More importantly, an enhanced drug release was observed in cells with higher expression of ALP genes (HeLa versus MDA-MB-231 and MCF7), confirming the ALP-responsiveness of the system inside living cells.
Published: 2023

6. N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer's Disease

Author: Universidad de Sevilla. Departamento de Química orgánica, Fundação para a Ciência e a Tecnologia (FCT), Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, Estonian Research Council, Gobierno de España, European Commission. Fondo Social Europeo (FSO), Islas Canarias ACIISI, Asociación Española Contra el Cáncer (AECC), European Cooperation in Science and Technology (COST), Universidad de Hadrec Králové (Facultad de Ciencias), Erasmus+, Hofmanova, Tereza, Marques, Carolina, García-Sosa, Alfonso T., López López, Óscar, Leitzbach, Luisa, Carreiro, Elisabete P., Fernández-Bolaños Guzmán, José María, Burke, Anthony J., Universidad de Sevilla. Departamento de Química orgánica, Fundação para a Ciência e a Tecnologia (FCT), Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, Estonian Research Council, Gobierno de España, European Commission. Fondo Social Europeo (FSO), Islas Canarias ACIISI, Asociación Española Contra el Cáncer (AECC), European Cooperation in Science and Technology (COST), Universidad de Hadrec Králové (Facultad de Ciencias), Erasmus+, Hofmanova, Tereza, Marques, Carolina, García-Sosa, Alfonso T., López López, Óscar, Leitzbach, Luisa, Carreiro, Elisabete P., Fernández-Bolaños Guzmán, José María, and Burke, Anthony J.
Abstract: The oxindole core is an important structural motif in many natural and synthetic substances with various biological activities including anticancer, antineurodegenerative, and antimicrobial properties. This report focuses on the synthesis and biological activity of a series of novel N-substituted 3-aminooxindoles and their assessment in cholinesterase (ChE) and monoamine oxidase (MAO) inhibition. With regard to MAO inhibition, a series of Npropargyl containing derivatives was synthesized and screened. Despite being weak inhibitors of MAO-A and MAO-B, the compounds were selective for butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE). Most of them were strong inhibitors of BuChE with IC50 ’ s of less than 1 µM, and one compound showed an IC50 = 27 nM. The mechanism of action of the inhibition was pin-pointed through molecular modeling, and was validated using saturation-transfer-difference (STD) NMR. Some of the compounds were screened for anti-oxidant properties, but showed no activity. The same compounds were screened in the neurodegenerative disease model cellline SH-SY5Y and although some were found to be non-cytotoxic, others were moderately cytotoxic. Continuous live cell imaging experiments showed that the compounds do not induce relevant cell damage and thus, the compounds might be interesting drug candidates for Alzheimer’s disease. Furthermore, the most active compounds showed excellent drug-likeness and pharmacological properties predicted using Swiss-ADME, and the pharmacokinetic simulations indicated that all these compounds cross the blood-brain-barrier.
Published: 2023

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Author: Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Agencia Estatal de Investigación. España, Instituto de Salud Carlos III, Euronanomed Program, Junta de Castilla-La Mancha, Junta de Andalucía, European Cooperation in Science and Technology (COST), European Regional Development Fund, de la Torre, Cristina, Játiva, Pablo, Posadas, Inmaculada, Manzanares, Darío, Jiménez Blanco, José Luis, Ortiz Mellet, Carmen, García Fernández, José Manuel, Ceña, Valentín, Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Agencia Estatal de Investigación. España, Instituto de Salud Carlos III, Euronanomed Program, Junta de Castilla-La Mancha, Junta de Andalucía, European Cooperation in Science and Technology (COST), European Regional Development Fund, de la Torre, Cristina, Játiva, Pablo, Posadas, Inmaculada, Manzanares, Darío, Jiménez Blanco, José Luis, Ortiz Mellet, Carmen, García Fernández, José Manuel, and Ceña, Valentín
Published: 2022

8. Comparative analysis of the germination of barley seeds subjected to drying, hydrogen peroxide, or oxidative air plasma treatments

Author: Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. Departamento de Física Aplicada I, Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Perea Brenes, Álvaro, Gómez Ramírez, Ana María, López Santos, Carmen, Oliva Ramirez, Manuel, Molina, Ricardo, Cotrino Bautista, José, García, José L., Cantos, Manuel, González Elipe, Agustín R., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. Departamento de Física Aplicada I, Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Perea Brenes, Álvaro, Gómez Ramírez, Ana María, López Santos, Carmen, Oliva Ramirez, Manuel, Molina, Ricardo, Cotrino Bautista, José, García, José L., Cantos, Manuel, and González Elipe, Agustín R.
Abstract: Acceleration in germination time by 12–24 h for barley seeds treated with atmospheric air plasmas may have a significant economic impact on malting processes. In this study, the increase in germination rate and decrease in contamination level upon plasma treatment could not be directly correlated with any significant increase in the water uptake capacity, except for seeds exposed to mild drying treatment. A variety of germination essays have been carried out with seeds impregnated with an abscisic acid solution, a retarding factor of germination, treated with a peroxide solution, and/or subjected to the plasma and drying treatments. Results suggest that plasma and hydrogen peroxide treatments induce the formation of reactive oxygen and nitrogen species that affects the abscisic acid factor and accelerate the germination rate.
Published: 2022

9. High-Grade Glioma Treatment Response Monitoring Biomarkers (1): A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 1: Perfusion and Diffusion Techniques

Author: Highfield Research Group, Cancer, the European Cooperation in Science and Technology (COST) Glioma MR Imaging 2.0 (GliMR) Initiative, Highfield Research Group, Cancer, and the European Cooperation in Science and Technology (COST) Glioma MR Imaging 2.0 (GliMR) Initiative
Published: 2022

10. Towards a Cross-Sectoral View of Nature-Based Solutions for Enabling Circular Cities

Author: Universidad de Sevilla. Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos, Universidad de Sevilla. AGR-268: Naturación Urbana e Ingeniería de Biosistemas, European Cooperation in Science and Technology (COST), Langergraber, Guenter, Castellar da Cunha, Joana América, Andersen, Theis Raaschou, Andreucci, Maria Beatrice, Baganz, Gösta F.M., Pineda-Martos, Rocío, Atanasova, Nataša, Universidad de Sevilla. Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos, Universidad de Sevilla. AGR-268: Naturación Urbana e Ingeniería de Biosistemas, European Cooperation in Science and Technology (COST), Langergraber, Guenter, Castellar da Cunha, Joana América, Andersen, Theis Raaschou, Andreucci, Maria Beatrice, Baganz, Gösta F.M., Pineda-Martos, Rocío, and Atanasova, Nataša
Abstract: A framework developed by the COST Action Circular City (an EU-funded network of 500+ scientists from 40+ countries; COST = Cooperation in Science and Technology) for addressing Urban Circularity Challenges (UCCs) with nature-based solutions (NBSs) was analyzed by various urban sectors which refer to different fields of activities for circular management of resources in cities (i.e., reducing use of resources and production of waste). The urban sectors comprise the built environment, urban water management, resource recovery, and urban farming. We present main findings from sector analyses, discuss different sector perspectives, and show ways to overcome these differences. The results reveal the potential of NBSs to address multiple sectors, as well as multiple UCCs. While water has been identified as a key element when using NBSs in the urban environment, most NBSs are interconnected and also present secondary benefits for other resources. Using representative examples, we discuss how a holistic and systemic approach could facilitate the circular use of resources in cities. Currently, there is often a disciplinary focus on one resource when applying NBSs. The full potential of NBSs to address multifunctionality is, thus, usually not fully accounted for. On the basis of our results, we conclude that experts from various disciplines can engage in a cross-sectoral exchange and identify the full potential of NBSs to recover resources in circular cities and provide secondary benefits to improve the livelihood for locals. This is an important first step toward the full multifunctionality potential enabling of NBSs.
Published: 2021

11. Nature-Based Solutions for Agriculture in Circular Cities: Challenges, Gaps, and Opportunities

Author: Universidad de Sevilla. Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos, Universidad de Sevilla. GR-268: Naturación Urbana e Ingeniería de Biosistemas., European Cooperation in Science and Technology (COST), Fundação para a Ciência e a Tecnologia. Portugal, Canet-Martí, Alba, Pineda-Martos, Rocío, Junge, Ranka, Bohn, Katrin, Paço, Teresa A., Delgado, Cecília, Alencikiene, Gitana, Skar, Siv Lene Gangenes, Baganz, Gösta F.M., Universidad de Sevilla. Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos, Universidad de Sevilla. GR-268: Naturación Urbana e Ingeniería de Biosistemas., European Cooperation in Science and Technology (COST), Fundação para a Ciência e a Tecnologia. Portugal, Canet-Martí, Alba, Pineda-Martos, Rocío, Junge, Ranka, Bohn, Katrin, Paço, Teresa A., Delgado, Cecília, Alencikiene, Gitana, Skar, Siv Lene Gangenes, and Baganz, Gösta F.M.
Abstract: Urban agriculture (UA) plays a key role in the circular metabolism of cities, as it can use water resources, nutrients, and other materials recovered from streams that currently leave the city as solid waste or as wastewater to produce new food and biomass. The ecosystem services of urban green spaces and infrastructures and the productivity of specific urban agricultural technologies have been discussed in literature. However, the understanding of input and output (I/O) streams of different nature-based solutions (NBS) is not yet sufficient to identify the challenges and opportunities they offer for strengthening circularity in UA. We propose a series of agriculture NBS, which, implemented in cities, would address circularity challenges in different urban spaces. To identify the challenges, gaps, and opportunities related to the enhancement of resources management of agriculture NBS, we evaluated NBS units, interventions, and supporting units, and analyzed I/O streams as links of urban circularity. A broader understanding of the food-related urban streams is important to recover resources and adapt the distribution system accordingly. As a result, we pinpointed the gaps that hinder the development of UA as a potential opportunity within the framework of the Circular City.
Published: 2021

12. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Author: Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, European Cooperation in Science and Technology (COST), National Centre for Research and Development, Ministry of Education, Youth and Sports of the Czech Republic, Czech Science Foundation, Vinarov, Zahari, Abrahamsson, Bertil, Artursson, Per, Batchelor, Hannah Katharine, Berben, Philippe, Bernkop Schnürch, Andreas, Meléndez Martínez, Antonio Jesús, Augustijns, Patrick, Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, European Cooperation in Science and Technology (COST), National Centre for Research and Development, Ministry of Education, Youth and Sports of the Czech Republic, Czech Science Foundation, Vinarov, Zahari, Abrahamsson, Bertil, Artursson, Per, Batchelor, Hannah Katharine, Berben, Philippe, Bernkop Schnürch, Andreas, Meléndez Martínez, Antonio Jesús, and Augustijns, Patrick
Abstract: Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
Published: 2021

13. Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis

Author: Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Economía y Competitividad (MINECO). España, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Consejo Europeo de Investigación, Herrera González, Irene, Sánchez Fernández, Elena Matilde, Sau, Abhijit, Nativi, Cristina, Garciá Fernández, José M., Galán, M. Carmen, Ortiz Mellet, Carmen, Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Economía y Competitividad (MINECO). España, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Consejo Europeo de Investigación, Herrera González, Irene, Sánchez Fernández, Elena Matilde, Sau, Abhijit, Nativi, Cristina, Garciá Fernández, José M., Galán, M. Carmen, and Ortiz Mellet, Carmen
Published: 2020

14. Genotoxic Effects of Cylindrospermopsin, Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line

Author: Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Ministerio de Economía y Competitividad (MINECO). España, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Díez-Quijada Jiménez, Leticia, Hercog, Klara, Štampar, Martina, Filipič, Metka, Cameán Fernández, Ana María, Jos Gallego, Ángeles Mencía, Žegura, Bojana, Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Ministerio de Economía y Competitividad (MINECO). España, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Cooperation in Science and Technology (COST), Díez-Quijada Jiménez, Leticia, Hercog, Klara, Štampar, Martina, Filipič, Metka, Cameán Fernández, Ana María, Jos Gallego, Ángeles Mencía, and Žegura, Bojana
Abstract: Simultaneous occurrence of cylindrospermopsin (CYN) and microcystin-LR (MCLR) has been reported in the aquatic environment and thus human exposure to such mixtures is possible. As data on the combined effects of CYN/MCLR are scarce, we aimed to investigate the adverse effects related to genotoxic activities induced by CYN (0.125, 0.25 and 0.5 µg/mL) and MCLR (1 µg/mL) as single compounds and their combinations in HepG2 cells after 24 and 72 h exposure. CYN and CYN/MCLR induced DNA double-strand breaks after 72 h exposure, while cell cycle analysis revealed that CYN and CYN/MCLR arrested HepG2 cells in G0/G1 phase. Moreover, CYN and the combination with MCLR upregulated CYP1A1 and target genes involved in DNA-damage response (CDKN1A, GADD45A). Altogether, the results showed that after 72 h exposure genotoxic activity of CYN/MCLR mixture was comparable to the one of pure CYN. On the contrary, MCLR (1 µg/mL) had no effect on the viability of cells and had no influence on cell division. It did not induce DNA damage and did not deregulate studied genes after prolonged exposure. The outcomes of the study confirm the importance of investigating the combined effects of several toxins as the effects can differ from those induced by single compounds.
Published: 2020

15. Development of silica‐based biodegradable submicrometric carriers and investigating their characteristics as in vitro delivery vehicles

Author: Universidad de Sevilla. Departamento de Química Inorgánica, Deutsche Forschungsgemeinschaft / German Research Foundation (DFG), Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC), Ministerio de Economía y Competitividad (MINECO). España, European Cooperation in Science and Technology (COST), Russian Foundation for Basic Research (RFBR), Zyuzin, Mikhail V., Zhu, Dingcheng, Parak, Wolfgang J., Feliu, Neus, Escudero Belmonte, Alberto, Universidad de Sevilla. Departamento de Química Inorgánica, Deutsche Forschungsgemeinschaft / German Research Foundation (DFG), Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC), Ministerio de Economía y Competitividad (MINECO). España, European Cooperation in Science and Technology (COST), Russian Foundation for Basic Research (RFBR), Zyuzin, Mikhail V., Zhu, Dingcheng, Parak, Wolfgang J., Feliu, Neus, and Escudero Belmonte, Alberto
Abstract: Nanostructured silica (SiO2)-based materials are attractive carriers for the delivery of bioactive compounds into cells. In this study, we developed hollow submicrometric particles composed of SiO2 capsules that were separately loaded with various bioactive molecules such as dextran, proteins, and nucleic acids. The structural characterization of the reported carriers was conducted using transmission and scanning electron microscopies (TEM/SEM), confocal laser scanning microscopy (CLSM), and dynamic light scattering (DLS). Moreover, the interaction of the developed carriers with cell lines was studied using standard viability, proliferation, and uptake assays. The submicrometric SiO2-based capsules loaded with DNA plasmid encoding green fluorescence proteins (GFP) were used to transfect cell lines. The obtained results were compared with studies made with similar capsules composed of polymers and show that SiO2-based capsules provide better transfection rates on the costs of higher toxicity.
Published: 2020

16. A Research Roadmap: Connected Health as an Enabler of Cancer Patient Support

Author: Universidad de Sevilla. Departamento de Arquitectura y Tecnología de Computadores, Universidad de Sevilla. Departamento de Motricidad Humana y Rendimiento Deportivo, European Cooperation in Science and Technology (COST), European Union (UE), Tatra banka Foundation, Research Agency in Slovakia, Fundação para a Ciência e a Tecnologia. Portugal, Ruiz Signorelli, Gabriel, Lehocki, Fedor, Mora Fernández, Matilde, O'Neill, Gillian, O'Connor, Dominic, Brennan, Louise, Monteiro Guerra, Francisco, Rivero Rodríguez, Alejandro, Hors Fraile, Santiago, Muñoz Penas, Juan, Bonjorn Dalmau, Mercé, Mota, Jorge, Oliveira, Ricardo B., Mrinakova, Bela, Putekova, Silvia, Muro, Naiara, Zambrana, Francisco, García Gómez, Juan M., Universidad de Sevilla. Departamento de Arquitectura y Tecnología de Computadores, Universidad de Sevilla. Departamento de Motricidad Humana y Rendimiento Deportivo, European Cooperation in Science and Technology (COST), European Union (UE), Tatra banka Foundation, Research Agency in Slovakia, Fundação para a Ciência e a Tecnologia. Portugal, Ruiz Signorelli, Gabriel, Lehocki, Fedor, Mora Fernández, Matilde, O'Neill, Gillian, O'Connor, Dominic, Brennan, Louise, Monteiro Guerra, Francisco, Rivero Rodríguez, Alejandro, Hors Fraile, Santiago, Muñoz Penas, Juan, Bonjorn Dalmau, Mercé, Mota, Jorge, Oliveira, Ricardo B., Mrinakova, Bela, Putekova, Silvia, Muro, Naiara, Zambrana, Francisco, and García Gómez, Juan M.
Abstract: The evidence that quality of life is a positive variable for the survival of cancer patients has prompted the interest of the health and pharmaceutical industry in considering that variable as a final clinical outcome. Sustained improvements in cancer care in recent years have resulted in increased numbers of people living with and beyond cancer, with increased attention being placed on improving quality of life for those individuals. Connected Health provides the foundations for the transformation of cancer care into a patient-centric model, focused on providing fully connected, personalized support and therapy for the unique needs of each patient. Connected Health creates an opportunity to overcome barriers to health care support among patients diagnosed with chronic conditions. This paper provides an overview of important areas for the foundations of the creation of a new Connected Health paradigm in cancer care. Here we discuss the capabilities of mobile and wearable technologies; we also discuss pervasive and persuasive strategies and device systems to provide multidisciplinary and inclusive approaches for cancer patients for mental well-being, physical activity promotion, and rehabilitation. Several examples already show that there is enthusiasm in strengthening the possibilities offered by Connected Health in persuasive and pervasive technology in cancer care. Developments harnessing the Internet of Things, personalization, patient-centered design, and artificial intelligence help to monitor and assess the health status of cancer patients. Furthermore, this paper analyses the data infrastructure ecosystem for Connected Health and its semantic interoperability with the Connected Health economy ecosystem and its associated barriers. Interoperability is essential when developing Connected Health solutions that integrate with health systems and electronic health records. Given the exponential business growth of the Connected Health economy, there is an urgent nee
Published: 2019

17. A Survey of Challenges for Runtime Verification from Advanced Application Domains (Beyond Software)

Author: Interdisciplinary Centre for Security, Reliability and Trust (SnT) > Software Verification and Validation Lab (SVV Lab) [research center], European Cooperation in Science and Technology (COST) [sponsor], Sánchez, César, Schneider, Gerardo, Ahrendt, Wolfgang, Bartocci, Ezio, Bianculli, Domenico, Colombo, Christian, Falcone, Yliés, Francalanza, Adrian, Krstic, Srdan, Lourenço, João, Nickovic, Dejan, Pace, Gordon J., Rufino, Jose, Signoles, Julien, Traytel, Dmitriy, Weiss, Alexander, Interdisciplinary Centre for Security, Reliability and Trust (SnT) > Software Verification and Validation Lab (SVV Lab) [research center], European Cooperation in Science and Technology (COST) [sponsor], Sánchez, César, Schneider, Gerardo, Ahrendt, Wolfgang, Bartocci, Ezio, Bianculli, Domenico, Colombo, Christian, Falcone, Yliés, Francalanza, Adrian, Krstic, Srdan, Lourenço, João, Nickovic, Dejan, Pace, Gordon J., Rufino, Jose, Signoles, Julien, Traytel, Dmitriy, and Weiss, Alexander
Abstract: Runtime verification is an area of formal methods that studies the dynamic analysis of execution traces against formal specifications. Typically, the two main activities in runtime verification efforts are the process of creating monitors from specifications, and the algorithms for the evaluation of traces against the generated monitors. Other activities involve the instrumentation of the system to generate the trace and the communication between the system under analysis and the monitor. Most of the applications in runtime verification have been focused on the dynamic analysis of software, even though there are many more potential applications to other computational devices and target systems. In this paper we present a collection of challenges for runtime verification extracted from concrete application domains, focusing on the difficulties that must be overcome to tackle these specific challenges. The computational models that characterize these domains require to devise new techniques beyond the current state of the art in runtime verification.
Published: 2019

18. SCORE: Simulator for cloud optimization of resources andenergy consumption

Author: Universidad de Sevilla. Departamento de Lenguajes y Sistemas Informáticos, European Cooperation in Science and Technology (COST), Fernández Cerero, Damián, Fernández-Montes González, Alejandro, Jakóbik, Agnieszka, Kołodziej, Joanna, Toro Bonilla, Miguel, Universidad de Sevilla. Departamento de Lenguajes y Sistemas Informáticos, European Cooperation in Science and Technology (COST), Fernández Cerero, Damián, Fernández-Montes González, Alejandro, Jakóbik, Agnieszka, Kołodziej, Joanna, and Toro Bonilla, Miguel
Abstract: Achieving efficiency both in terms of resource utilisation and energy consumption is acomplex challenge, especially in large-scale wide-purpose data centers that serve cloud- computing services. Simulation presents an appropriate solution for the development andtesting of strategies that aim to improve efficiency problems before their applications inproduction environments. Various cloud simulators have been proposed to cover differentaspects of the operation environment of cloud-computing systems. In this paper, we define the SCORE tool, which is dedicated to the simulation of energy-efficient monolithicand parallel-scheduling models and for the execution of heterogeneous, realistic and synthetic workloads. The simulator has been evaluated through empirical tests. The results ofthe experiments confirm that SCORE is a performant and reliable tool for testing energy- efficiency, security, and scheduling strategies in cloud-computing environments.
Published: 2018

19. Effective Interaction between Active Colloids and Fluid Interfaces Induced by Marangoni Flows

Author: Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, European Cooperation in Science and Technology (COST), Domínguez Álvarez, Álvaro, Malgaretti, Paolo, Popescu, Mihail N., Dietrich, Siegfried, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, European Cooperation in Science and Technology (COST), Domínguez Álvarez, Álvaro, Malgaretti, Paolo, Popescu, Mihail N., and Dietrich, Siegfried
Abstract: We show theoretically that near a fluid-fluid interface a single active colloidal particle generating, e.g., chemicals or a temperature gradient experiences an effective force of hydrodynamic origin. This force is due to the fluid flow driven by Marangoni stresses induced by the activity of the particle; it decays very slowly with the distance from the interface, and can be attractive or repulsive depending on how the activity modifies the surface tension. We show that, for typical systems, this interaction can dominate the dynamics of the particle as compared to Brownian motion, dispersion forces, or self-phoretic effects. In the attractive case, the interaction promotes the self-assembly of particles into a crystal-like monolayer at the interface.
Published: 2016

20. A New Multi-Objective Approach for Molecular Docking Based on RMSD and Binding Energy

Author: Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, European Cooperation in Science and Technology (COST), López Camacho, Esteban, García Godoy, María Jesús, García Nieto, José Manuel, Nebro, Antonio J., Aldana Montes, José F., Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, European Cooperation in Science and Technology (COST), López Camacho, Esteban, García Godoy, María Jesús, García Nieto, José Manuel, Nebro, Antonio J., and Aldana Montes, José F.
Abstract: Ligand-protein docking is an optimization problem based on predicting the position of a ligand with the lowest binding energy in the active site of the receptor. Molecular docking problems are traditionally tackled with single-objective, as well as with multi-objective approaches, to minimize the binding energy. In this paper, we propose a novel multi-objective formulation that considers: the Root Mean Square Deviation (RMSD) di erence in the coordinates of ligands and the binding (intermolecular) energy, as two objectives to evaluate the quality of the ligand-protein interactions. To determine the kind of Pareto front approximations that can be obtained, we have selected a set of representative multi-objective algorithms such as NSGA-II, SMPSO, GDE3, and MOEA/D. Their performances have been assessed by applying two main quality indicators intended to measure convergence and diversity of the fronts. In addition, a comparison with LGA, a reference single-objective evolutionary algorithm for molecular docking (AutoDock) is carried out. In general, SMPSO shows the best overall results in terms of energy and and RMSD (value lower than 2 A for successful docking results). This new multi-objective approach shows an improvement over the ligand-protein docking predictions that could be promising in in silico docking studies to select new anticancer compounds for therapeutic targets that are multidrug resistant.
Published: 2016

21. A Study of Archiving Strategies in Multi-Objective PSO for Molecular Docking

Author: Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, European Cooperation in Science and Technology (COST), García Nieto, José Manuel, López Camacho, Esteban, García Godoy, María Jesús, Nebro, Antonio J., Durillo, Juan J., Aldana Montes, José F., Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, European Cooperation in Science and Technology (COST), García Nieto, José Manuel, López Camacho, Esteban, García Godoy, María Jesús, Nebro, Antonio J., Durillo, Juan J., and Aldana Montes, José F.
Abstract: Molecular docking is a complex optimization problem aimed at predicting the position of a ligand molecule in the active site of a receptor with the lowest binding energy. This problem can be formulated as a bi-objective optimization problem by minimizing the binding energy and the Root Mean Square Deviation (RMSD) di erence in the coordinates of ligands. In this context, the SMPSO multi-objective swarm-intelligence algorithm has shown a remarkable performance. SMPSO is characterized by having an external archive used to store the non-dominated solutions and also as the basis of the leader selection strategy. In this paper, we analyze several SMPSO variants based on di erent archiving strategies in the scope of a benchmark of molecular docking instances. Our study reveals that the SMPSOhv, which uses an hypervolume contribution based archive, shows the overall best performance.
Published: 2016

22. Characterization of the largest relic Eurasian wild grapevine reservoir in Southern Iberian Peninsula

Author: Universidad de Sevilla. Departamento de Zoología, European Cooperation in Science and Technology (COST), Arroyo García, Rosa, Cantos, Manuel, Lara, Miguel, López Martínez, María Ángeles, Gallardo Cano, Antonio, Alvar Ocete, Carlos, Pérez, Ángeles, Bánáti, Hajnalka, García, José Luis, Ocete Rubio, Rafael, Universidad de Sevilla. Departamento de Zoología, European Cooperation in Science and Technology (COST), Arroyo García, Rosa, Cantos, Manuel, Lara, Miguel, López Martínez, María Ángeles, Gallardo Cano, Antonio, Alvar Ocete, Carlos, Pérez, Ángeles, Bánáti, Hajnalka, García, José Luis, and Ocete Rubio, Rafael
Abstract: Wild grapevine is becoming a threatened species in the Iberian Peninsula due to human impacts. The aim of this work was to carry out a holistic study for six years of the largest wild grapevine population found up to date in SW Iberian Peninsula. This population has 115 vines. Ampelographic and soil characteristics have been studied. Evaluation of its environment has also been studied by describing the main parasitic species and natural enemies of pests. The ability of this plant material for its micropropaga-tion and storage in slow-growth conditions has been tested. Microvinification resulted in a wine with good acidity and medium color intensity, two interesting characteristics under a warm climatology. Finally, the identification of private alleles in this wild popula-tion, absent in other locations from the Northern and Southern Iberian territories, is a very valuable feature and confirms the im-portance of establishing conservation programs. The population here studied is genetically unique and potentially useful for com-mercial rootstocks and cultivars breeding that would improve viticulture and enology.
Published: 2016

23. Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles

Author: Universidad de Sevilla. Departamento de Química orgánica, French National Research Agency (ANR), Fondation pour la Recherche Medicale (FRM), Gobierno de España, Junta de Andalucía, European Union (UE), European Cooperation in Science and Technology (COST), Khanal, Manakamana, Larsonneur, Fanny, Raks, Victoriia, Barras, Alexandre, Baumann, Jean-Sébastien, Martin, Fernando Ariel, Boukherroub, Rabah, Ghigo, Jean Marc, Ortiz Mellet, Carmen, Zaitsev, Vladimir, Garcia Fernandez, Jose M., Beloin, Christophe, Siriwardena, Aloysius, Szunerits, Sabine, Universidad de Sevilla. Departamento de Química orgánica, French National Research Agency (ANR), Fondation pour la Recherche Medicale (FRM), Gobierno de España, Junta de Andalucía, European Union (UE), European Cooperation in Science and Technology (COST), Khanal, Manakamana, Larsonneur, Fanny, Raks, Victoriia, Barras, Alexandre, Baumann, Jean-Sébastien, Martin, Fernando Ariel, Boukherroub, Rabah, Ghigo, Jean Marc, Ortiz Mellet, Carmen, Zaitsev, Vladimir, Garcia Fernandez, Jose M., Beloin, Christophe, Siriwardena, Aloysius, and Szunerits, Sabine
Abstract: Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles displaying activity against biofilms. In this work, trimeric thiomannoside clusters conjugated to nanodiamond particles (ND) were targeted for investigation. NDs have attracted attention as a biocompatible nanomaterial and we were curious to see whether the high mannose glycotope density obtained upon grouping monosaccharide units in triads might lead to the corresponding ND-conjugates behaving as effective inhibitors of E. coli type 1 fimbriae-mediated adhesion as well as of biofilm formation. The required trimeric thiosugar clusters were obtained through a convenient thiol-ene "click" strategy and were subsequently conjugated to alkynyl-functionalized NDs using a Cu(I)-catalysed "click" reaction. We demonstrated that the tri-thiomannoside cluster-conjugated NDs (ND-Man3) show potent inhibition of type 1 fimbriae-mediated E. coli adhesion to yeast and T24 bladder cells as well as of biofilm formation. The biofilm disrupting effects demonstrated here have only rarely been reported in the past for analogues featuring such simple glycosidic motifs. Moreover, the finding that the tri-thiomannoside cluster (Man3N3) is itself a relatively efficient inhibitor, even when not conjugated to any ND edifice, suggests that alternative mono- or multivalent sugar-derived analogues might also be usefully explored for E. coli-mediated biofilm disrupting properties.
Published: 2015

24. This title is unavailable for guests, please login to see more information.

Author: Universidad de Sevilla. Departamento de Química orgánica, Swiss National Science Foundation (SNFS), European Cooperation in Science and Technology (COST), Office Fédéral de l'Education et de la Science (Bern), Dirección General de Investigación Científica y Técnica (DGICYT). España, SOCRATES (EPFL/Sevilla) program, Gerber-Lemaire, S., Popowycz, Florence, Rodriguez García, Eliazar, Schütz, Catherine, Carmona Asenjo, Ana Teresa, Robina Ramírez, Inmaculada, Vogel, Pierre, Universidad de Sevilla. Departamento de Química orgánica, Swiss National Science Foundation (SNFS), European Cooperation in Science and Technology (COST), Office Fédéral de l'Education et de la Science (Bern), Dirección General de Investigación Científica y Técnica (DGICYT). España, SOCRATES (EPFL/Sevilla) program, Gerber-Lemaire, S., Popowycz, Florence, Rodriguez García, Eliazar, Schütz, Catherine, Carmona Asenjo, Ana Teresa, Robina Ramírez, Inmaculada, and Vogel, Pierre
Published: 2002

25. Are physicochemical properties shaping the allergenic potency of plant allergens?

Author: Laura Martín-Pedraza, Colette Larré, Thomas Holzhauser, Pedro M. Rodrigues, Daniel Lozano-Ojalvo, Karin Hoffmann-Sommergruber, Sara Benedé, Isabel Mafra, Gabriel Mazzucchelli, Tanja Cirkovic-Velickovic, Annette Kuehn, Cristian Piras, Joana Costa, Denise Schrama, Eva Gelencser, Kitty C.M. Verhoeckx, Cristina Bueno-Díaz, Roberta Lupi, Linda Monaci, Araceli Díaz-Perales, Julia Klueber, Caterina Villa, Simona L. Bavaro, Elena Molina, Paola Roncada, European Commission, Fundação para a Ciência e a Tecnologia (Portugal), Ministry of Education, Science and Technological Development (Serbia), Ministério da Ciência, Tecnologia e Ensino Superior (Portugal), Fonds National de la Recherche Luxembourg, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade do Porto, Istituto di Bioscienze e BioRisorse [Palermo] (IBBR), Consiglio Nazionale delle Ricerche (CNR), Teagasc Food Research Centre, Food Chemistry and Technology department, Moorepark, Fermoy, Country Cork, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), European Cooperation in Science and Technology (COST) Office, European Cooperation in Science and Technology (COST) : FA1402, Portuguese Foundation for Science and Technology, European Commission : UIDB 50006/2020, projects AlleRiskAssess, PTDC/BAA-AGR/31720/2017, NORTE-01-0145-FEDER-00001, FCT - POPH-QREN, PD/BD/114576/2016, Ministry of Education, Science and Technological Development of the Republic of Serbia : OI172024, Portuguese Foundation for Science and Technology European Commission : UIDB/04326/2020, and 16-02-01-FMP0014.Luxembourg National Research FundPRIDE/11012546/NEXTIMMUNEPersonalised Medicine Consortium (PMC), Luxembourg PMC/2017/02
Subjects: Allergy, LIPID TRANSFER PROTEIN, PRU P 3, Food processing, Protein family, [SDV]Life Sciences [q-bio], Plant allergens, Clinical manifestation, Computational biology, Protein aggregation, Biology, PEANUT ALLERGENS, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Medicine and Health Sciences, Immunology and Allergy, Potency, Animals, Humans, ARA H 1, SEED STORAGE PROTEINS, Matrix effect, ComputingMilieux_MISCELLANEOUS, Plant Proteins, 2. Zero hunger, 030203 arthritis & rheumatology, ALPHA-AMYLASE INHIBITOR, General Medicine, IN-VITRO DIGESTION, Allergens, COMPONENT-RESOLVED DIAGNOSIS, medicine.disease, 3. Good health, EXERCISE-INDUCED ANAPHYLAXIS, Animal allergens, WHEAT GLUTEN PROTEINS, Protein families, Plant protein, Allergenicity, Pollen, Food Hypersensitivity, 030215 immunology
Abstract: This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing., The authors highly appreciate the support from the European Cooperation in Science and Technology (COST) Office. This article is based upon work from COST Action FA1402, supported by COST (www.cost.eu). This work was also supported by Fundação para a Ciência e Tecnologia under the Partnership Agreement UIDB 50006/2020 and by the projects AlleRiskAssess - PTDC/BAA-AGR/31720/2017 and NORTE-01-0145-FEDER-00001. C.V. is grateful to FCT grants (PD/BD/114576/2016) financed by POPH-QREN (subsidised by FSE and MCTES). T.C.V. is grateful to the Ministry of Education, Science and Technological Development of the Republic of Serbia through grant number OI172024. P.M.R. and D.S. are grateful to FCT through project UIDB/04326/2020 and Mar2020 16–02-01-FMP-0014 – ‘ALLYFISH’. J.K. and A.K. acknowledge the PRIDE program grant (PRIDE/11012546/NEXTIMMUNE) by the Fonds National de la Recherche (FNR), Luxembourg and a translational grant (APSIS, PMC/2017/02) by the Personalised Medicine Consortium (PMC), Luxembourg.
Published: 2021
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26. Measurement-based Feasibility Exploration on Detecting and Localizing Multiple Humans Using MIMO Radio Channel Properties

Author: Yang Miao, Emmeric Tanghe, Jun-Ichi Takada, Troels Pedersen, Pierre Laly, Davy P. Gaillot, Martine Lienard, Luc Martens, Wout Joseph, Telecommunication Engineering, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Télécommunication, Interférences et Compatibilité Electromagnétique (IEMN-TELICE), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Excellence of Science (EOS) Project MUlti-SErvice WIreless NETworks MUSE-WINET within Inclusive Radio Communications (IRACON) of European Cooperation in Science and Technology (COST)European Cooperation in Science and Technology (COST) [CA15104], PCMP C2EM, COST, and Télécommunication, Interférences et Compatibilité Electromagnétique - IEMN (TELICE - IEMN)
Subjects: Power delay angular profile, Technology and Engineering, General Computer Science, power delay angular, Computer science, Acoustics, MIMO, MODELS, passive detection and localization of humans, power delay angular profile, 02 engineering and technology, law.invention, [SPI]Engineering Sciences [physics], Passive detection and localization of humans, 0203 mechanical engineering, law, Reverberation time, 0202 electrical engineering, electronic engineering, information engineering, LOCATION, General Materials Science, Radar, profile, 020301 aerospace & aeronautics, General Engineering, 020206 networking & telecommunications, LOCALIZATION, SENSOR, RADAR, Power (physics), TIME, reverberation time, lcsh:Electrical engineering. Electronics. Nuclear engineering, lcsh:TK1-9971, Power delay profile, Multipath propagation, Indoor radio channel, Communication channel
Abstract: International audience; This paper explores the feasibility of using the multiple-input multiple-output (MIMO) radio channel properties to passively detect and localize multiple humans in indoor environments. We propose to utilize the unique reverberation characteristics of indoor channels for the purpose of detecting, and the power angular delay profile (PADP) for localizing humans. On the one hand, the reverberation time corresponds with the decay rate of multipath in a closed or partially closed cavity, and varies with the change of the number of humans or the moving of humans relative to the antennas at link ends. On the other hand, the PADP is proposed to be calculated by the Multiple Signal Classification (MUSIC) super resolution algorithm with frequency smoothing preprocessing. The proposed approach is evaluated based on real-world MIMO radio channel measurements obtained from a meeting room. Measurements with and without the presence of humans have been conducted, where the maximum number of humans considered is four. Humans facing different directions, either in parallel or orthogonal to the direct line between the transmit and the receive antennas have been taken into account. In term of the detection feasibility, it is found that the change of the number of humans as well as the change of their facing/moving directions inside the partial reverberant region can be reflected on the change of the reverberation time estimated from the power delay profile of channel. In term of the localization feasibility, it is found that single human location can be well associated to the peak of the variation of the PADP during his/her movement, while multiple humans' movements result in obvious power variation in the very vicinity of some of them, and also in the vicinity of some background objects that is far from target humans.
Published: 2020
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27. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

Author: Anke Fuchs, Mateusz Gliwiński, Nathali Grageda, Rachel Spiering, Abul K. Abbas, Silke Appel, Rosa Bacchetta, Manuela Battaglia, David Berglund, Bruce Blazar, Jeffrey A. Bluestone, Martin Bornhäuser, Anja ten Brinke, Todd M. Brusko, Nathalie Cools, Maria Cristina Cuturi, Edward Geissler, Nick Giannoukakis, Karolina Gołab, David A. Hafler, S. Marieke van Ham, Joanna Hester, Keli Hippen, Mauro Di Ianni, Natasa Ilic, John Isaacs, Fadi Issa, Dorota Iwaszkiewicz-Grześ, Elmar Jaeckel, Irma Joosten, David Klatzmann, Hans Koenen, Cees van Kooten, Olle Korsgren, Karsten Kretschmer, Megan Levings, Natalia Maria Marek-Trzonkowska, Marc Martinez-Llordella, Djordje Miljkovic, Kingston H.G. Mills, Joana P. Miranda, Ciriaco A. Piccirillo, Amy L. Putnam, Thomas Ritter, Maria Grazia Roncarolo, Shimon Sakaguchi, Silvia Sánchez-Ramón, Birgit Sawitzki, Ljiljana Sofronic-Milosavljevic, Megan Sykes, Qizhi Tang, Marta Vives-Pi, Herman Waldmann, Piotr Witkowski, Kathryn J. Wood, Silvia Gregori, Catharien M. U. Hilkens, Giovanna Lombardi, Phillip Lord, Eva M. Martinez-Caceres, Piotr Trzonkowski, CRTD-DFG Research Center for Regenerative Therapies Dresden [Dresden, Germany] (Medical Faculty), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Medical University of Gdańsk, King‘s College London, Newcastle University [Newcastle], University of California [San Francisco] (UCSF), University of California, University of Bergen (UiB), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, IRCCS Ospedale San Raffaele [Milan, Italy], Uppsala University, University of Minnesota [Twin Cities] (UMN), University of Minnesota System, University of Amsterdam [Amsterdam] (UvA), University of Florida [Gainesville] (UF), University of Antwerp (UA), Antwerp University Hospital [Edegem] (UZA), Dendritic cells and immunoregulation in transplantation and immunopathology (Team 1 - U1064 Inserm - CRTI), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), University Hospital Regensburg, Carnegie Mellon University [Pittsburgh] (CMU), University of Chicago, Yale University School of Medicine, University of Oxford [Oxford], University of Chieti-Pescara, University of Belgrade [Belgrade], NHS Foundation Trust [London], The Royal Marsden, Medical School of Hannover (MHH), Radboud University Medical Center [Nijmegen], Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Leiden University Medical Center (LUMC), Uppsala University Hospital, University of Gothenburg (GU), Helmholtz-Zentrum München (HZM), BC Children's Hospital Research Institute [Vancouver, BC, Canada] (BCCHR), University of British Columbia (UBC), Trinity College Dublin, Universidade de Lisboa (ULISBOA), McGill University = Université McGill [Montréal, Canada], National University of Ireland [Galway] (NUI Galway), Stanford University School of Medicine [CA, USA], Osaka University [Osaka], Department of Clinical Immunology, Hospital Clínico San Carlos, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Columbia University [New York], Institut d’Investigació Germans Trias i Pujol = Germans Trias i Pujol Research Institute (IGTP), The University of Chicago Medicine [Chicago], Universitat Autònoma de Barcelona (UAB), This work was supported by a grant from the European Cooperation in Science and Technology (COST) for the AFACTT project (Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies, BM1305). COST is part of the EU Framework Programme Horizon 2020., European Project: COST, EU Horizon 2020, University of California [San Francisco] (UC San Francisco), University of California (UC), Yale School of Medicine [New Haven, Connecticut] (YSM), University of Oxford, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Helmholtz Zentrum München = German Research Center for Environmental Health, Universidade de Lisboa = University of Lisbon (ULISBOA), Le Bihan, Sylvie, European Cooperation in Science and Technology - COST - INCOMING, Universiteit Leiden, AII - Inflammatory diseases, AII - Infectious diseases, and Landsteiner Laboratory
Subjects: 0301 basic medicine, Medicin och hälsovetenskap, allograft, immune tolerance, adoptive transfer, Standardization, medicine.medical_treatment, Bioinformatics, Medical and Health Sciences, Immune tolerance, Cell therapy, expansion, Immunology and Allergy, Medicine, Good manufacturing practice, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, tolerance, chimeric antigen receptor, Minimum Information Model, T Regulatory Cells, Immunotherapy, Good Manufacturing Practice, Cell Therapy, Immune Tolerance, hemic and immune systems, Classification, 3. Good health, minimum information model, Medical Microbiology, immunotherapy, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], lcsh:Immunologic diseases. Allergy, T regulatory cells, Immunology, therapies, chemical and pharmacologic phenomena, in-vitro, Autoimmune Disease, Vaccine Related, versus-host-disease, 03 medical and health sciences, blood, business.industry, Inflammatory and immune system, Chimeric antigen receptor, Transplantation, Clinical trial, 030104 developmental biology, good manufacturing practice, Human medicine, cell therapy, business, lcsh:RC581-607, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, transplantation
Abstract: Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications. This work was supported by a grant from the European Cooperation in Science and Technology (COST) for the AFACTT project (Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies; BM1305). COST is part of the EU Framework Programme Horizon 2020. peer-reviewed
Published: 2018
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28. Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices

Author: Periklis Charalampous, Juanita A. Haagsma, Lea S. Jakobsen, Vanessa Gorasso, Isabel Noguer, Alicia Padron-Monedero, Rodrigo Sarmiento, João Vasco Santos, Scott A. McDonald, Dietrich Plass, Grant M. A. Wyper, Ricardo Assunção, Elena von der Lippe, Balázs Ádám, Ala'a AlKerwi, Jalal Arabloo, Ana Lúcia Baltazar, Boris Bikbov, Maria Borrell-Pages, Iris Brus, Genc Burazeri, Serafeim C. Chaintoutis, José Chen-Xu, Nino Chkhaberidze, Seila Cilovic-Lagarija, Barbara Corso, Sarah Cuschieri, Carlotta Di Bari, Keren Dopelt, Mary Economou, Theophilus I. Emeto, Peter Fantke, Florian Fischer, Alberto Freitas, Juan Manuel García-González, Federica Gazzelloni, Mika Gissler, Artemis Gkitakou, Hakan Gulmez, Sezgin Gunes, Sebastian Haller, Romana Haneef, Cesar A. Hincapié, Paul Hynds, Jane Idavain, Milena Ilic, Irena Ilic, Gaetano Isola, Zubair Kabir, Maria Kamusheva, Pavel Kolkhir, Naime Meriç Konar, Polychronis Kostoulas, Mukhtar Kulimbet, Carlo La Vecchia, Paolo Lauriola, Miriam Levi, Marjeta Majer, Enkeleint A. Mechili, Lorenzo Monasta, Stefania Mondello, Javier Muñoz Laguna, Evangelia Nena, Edmond S. W. Ng, Paul Nguewa, Vikram Niranjan, Iskra Alexandra Nola, Rónán O'Caoimh, Marija Obradović, Elena Pallari, Mariana Peyroteo, Vera Pinheiro, Nurka Pranjic, Miguel Reina Ortiz, Silvia Riva, Cornelia Melinda Adi Santoso, Milena Santric Milicevic, Tugce Schmitt, Niko Speybroeck, Maximilian Sprügel, Paschalis Steiropoulos, Aleksandar Stevanovic, Lau Caspar Thygesen, Fimka Tozija, Brigid Unim, Hilal Bektaş Uysal, Orsolya Varga, Milena Vasic, Rafael José Vieira, Vahit Yigit, Brecht Devleesschauwer, Sara M. Pires, Unión Europea. European Cooperation in Science and Technology (COST), and UCL - SSS/IRSS - Institut de recherche santé et société
Subjects: Epidemiology, Communicable diseases -- Europe, FOODBORNE DISEASES, Communicable diseases -- Europe -- Statistics, Communicable Diseases, Disability-adjusted life years, Cost of Illness, SDG 3 - Good Health and Well-being, systematic review, SURVEILLANCE, Medicine and Health Sciences, Humans, Communicable diseases -- Great Britain, Veterinary Sciences, Communicable diseases -- Epidemiology -- Europe, disability-adjusted life years, Netherlands, Disability-adjusted life years -- Europe, Methodology, Burden of disease, Burden of disease, infectious diseases, disability-adjusted life years, systematic review, methodology, methodology, GLOBAL BURDEN, United Kingdom, Europe, Infectious Diseases, Global burden of disease -- Europe, Systematic review, Infectious diseases, Quality-Adjusted Life Years, CHALLENGE
Abstract: This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the Disability-Adjusted Life Years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3,053 studies of which 2,948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results., peer-reviewed
Published: 2023
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29. Risks, benefits, and knowledge gaps of non-native tree species in Europe

Author: Anastazija Dimitrova, Katalin Csilléry, Marcin Klisz, Mathieu Lévesque, Steffi Heinrichs, Maxime Cailleret, Enrique Andivia, Palle Madsen, Henrik Böhenius, Branislav Cvjetkovic, Bart De Cuyper, Giovanbattista de Dato, Peter Ferus, Berthold Heinze, Vladan Ivetić, Zoltan Köbölkuti, Jelena Lazarević, Dagnija Lazdina, Tiit Maaten, Kristaps Makovskis, Jelena Milovanović, Antonio T. Monteiro, Marina Nonić, Simon Place, Radoslaw Puchalka, Antonio Montagnoli, Ss. Cyril and Methodius University in Skopje (UKIM), Swiss Federal Institute for Forest, Snow and Landscape Research WSL, FOREST RESEARCH INSTITUTE RASZYN POL, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Department of Environmental Systems Science [ETH Zürich] (D-USYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Georg-August-University = Georg-August-Universität Göttingen, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), InNovaSilva ApS, Swedish University of Agricultural Sciences (SLU), University of Banja Luka, Research Institute for Nature and Forest (INBO), CREA – Research Centre for Forestry and Wood, Arezzo, Italy, Slovak Academy of Sciences (SAS), Austrian Research Centre for Forests (BFW), University of Belgrade [Belgrade], University of West Hungary [Sopron], University of Montenegro (UCG), Latvian State Forest Research Institute 'Silava', ESTONIAN UNIVERSITY OF LIFE SCIENCES TARTU EST, Singidunum University, University Institute of Lisbon (ISCTE), Chartered Forester UK, Nicolaus Copernicus University [Toruń], Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), European Cooperation in Science and Technology (COST)CA19128, Appeared in source as:COST (European Cooperation in Science and Technology), and Repositório da Universidade de Lisboa
Subjects: Invasive species, Ecology, Grey literature, Forestry, Distribution, Non-native tree species, assisted migration, climate change, database, distribution, forestry, grey literature, hybridization, invasive species, Climate change, Hybridization, Database, Assisted migration, Europe, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Ecology, Evolution, Behavior and Systematics
Abstract: Changing ecosystem conditions and diverse socio-economical events have contributed to an ingrained presence of non-native tree species (NNTs) in the natural and cultural European landscapes. Recent research endeavors have focused on different aspects of NNTs such as legislation, benefits, and risks for forestry, emphasizing that large knowledge gaps remain. As an attempt to fulfill part of these gaps, within the PEN-CAFoRR COST Action (CA19128) network, we established an open-access questionnaire that allows both academic experts and practitioners to provide information regarding NNTs from 20 European countries. Then, we integrated the data originating from the questionnaire, related to the country-based assessment of both peer-reviewed and grey literature, with information from available datasets (EUFORGEN and EU-Forest), which gave the main structure to the study and led to a mixed approach review. Finally, our study provided important insights into the current state of knowledge regarding NNTs. In particular, we highlighted NNTs that have shown to be less commonly addressed in research, raising caution about those characterized by an invasive behavior and used for specific purposes (e.g., wood production, soil recultivation, afforestation, and reforestation). NNTs were especially explored in the context of resilient and adaptive forest management. Moreover, we emphasized the assisted and natural northward migration of NNTs as another underscored pressing issue, which needs to be addressed by joint efforts, especially in the context of the hybridization potential. This study represents an additional effort toward the knowledge enhancement of the NNTs situation in Europe, aiming for a continuously active common source deriving from interprofessional collaboration., Frontiers in Ecology and Evolution, 10, ISSN:2296-701X
Published: 2022
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30. Meteoritic amino acids as chemical tracers of parent-body chemistries

Author: F. Pauzat, Y. Ellinger, Brigitte Zanda, Jean-Claude Guillemin, M. Lattelais, Laboratoire de chimie théorique (LCT), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Laboratoire de Minéralogie et Cosmochimie du Muséum (LMCM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Programme National Physique et Chimie du Milieu Interstellaire (PCMI) of CNRS/Institut National des Sciences de l'Univers (INSU), Institut National de Chimie/Institut National de Planetologie (INC/INP) - CEA, COST Action European Cooperation in Science and Technology (COST) [CM0805], Region Ile de France DIM ACAV (Astrophysique et Conditions d'Apparition de la Vie), CNES Centre National D'etudes Spatiales, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nitrile, Context (language use), Protonation, 010502 geochemistry & geophysics, 01 natural sciences, meteorites, methods: numerical, chemistry.chemical_compound, Chondrite, Computational chemistry, 0103 physical sciences, [CHIM]Chemical Sciences, meteors, meteoroids, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Physics, chemistry.chemical_classification, Aqueous solution, Astronomy and Astrophysics, Chemical formula, ISM: molecules, Amino acid, chemistry, 13. Climate action, Space and Planetary Science, Carbonaceous chondrite
Abstract: The analysis of the organic matter of meteorites made it possible to identify over 70 amino acids (AA), including 8 of those found in living organisms. However, their relative abundances vary drastically with the type of the carbonaceous chondrite, even for isomers of same chemical formula. In this report, we address the question whether this difference may have its origin in the relative stability of these isomers according to the conditions they experienced when they were formed and after. To this end, we rely on the fact that for most of the species observed so far in the interstellar medium (ISM), the most abundant isomer of a given generic chemical formula is the most stable one (minimum energy principle, MEP). Using quantum density functional theory (DFT) simulations, we investigate the relative stability of the lowest energy isomers of alanine (Ala) and amino butyric acid (ABA) in the neutral, protonated, and zwitterionic structures together with corresponding nitrile precursors. It is shown that β-alanine and γ-ABA are the most stable in a protonated form, whereas α-AA are the most stable in the zwitterionic and nitrile structures. The different composition of the carbonaceous chondrites CIs and CMs could be linked to the chemical context of the aqueous alterations of the parent bodies.
Published: 2021
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31. Comparative analysis of the germination of barley seeds subjected to drying, hydrogen peroxide, or oxidative air plasma treatments

Author: Alvaro Perea‐Brenes, Ana Gómez‐Ramírez, Carmen López‐Santos, Manuel Oliva‐Ramírez, Ricardo Molina, José Cotrino, José L. García, Manuel Cantos, Agustín R. González‐Elipe, Junta de Andalucía, European Commission, Ministerio de Ciencia e Innovación (España), European Cooperation in Science and Technology, Universidad de Sevilla, Gómez-Ramírez, Ana, López-Santos, Carmen, Molina, Ricardo, García Fernández, José Luis, Cantos, Manuel, González-Elipe, Agustin R., Gómez-Ramírez, Ana [0000-0003-4402-7515], López-Santos, Carmen [0000-0001-8782-7331], Molina, Ricardo [0000-0001-6324-4983], García Fernández, José Luis [0000-0001-7880-2343], Cantos, Manuel [0000-0001-8672-4437], González-Elipe, Agustin R. [0000-0002-6417-1437], Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. Departamento de Física Aplicada I, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, and European Cooperation in Science and Technology (COST)
Subjects: Polymers and Plastics, Plasma surface oxidation, ABA factor, Barley germination, Condensed Matter Physics, Hydrogen peroxide treatment
Abstract: 17 páginas.- 10 figura.- 1 tablas.- 63 referencias, Acceleration in germination time by 12-24 h for barley seeds treated with atmospheric air plasmas may have a significant economic impact on malting processes. In this study, the increase in germination rate and decrease in contamination level upon plasma treatment could not be directly correlated with any significant increase in the water uptake capacity, except for seeds exposed to mild drying treatment. A variety of germination essays have been carried out with seeds impregnated with an abscisic acid solution, a retarding factor of germination, treated with a peroxide solution, and/or subjected to the plasma and drying treatments. Results suggest that plasma and hydrogen peroxide treatments induce the formation of reactive oxygen and nitrogen species that affects the abscisic acid factor and accelerate the germination rate. ABA factorbarley germinationhydrogen peroxide treatmentplasma surface oxidation, the financial support of the Consejeria de Economia, Conocimiento, Empresas y Universidad de la Junta de Andalucia through first the project US-1381045, and second the US-1380977, as well as the EU through cohesion fund and FEDER 2014-2020 programs for financial support. We also thank the AEI-MICINN (PID2019-110430GB-C21, PID2019-109603RA-10, and PID2020-114270RA-I00 funded by MCIN/AEI/10.13039/501100011033 and by "ERDF (FEDER) A way of making Europe," by the "European Union." The contribution of Arquimea Research for the realization of parts of this study is also acknowledged. We thank Intermalta S.A. for the seeds supply. This article frames within COST Action PIAgri-CA19110, supported by COST (European Cooperation in Science and Technology), . Carmen Lopez-Santos thanks the support of the University of Seville through the VI PPIT-US and the Ramon y Cajal Spanish National programs funded by MCIN/AEI/10.13039/501100011033. Manuel Oliva-Ramirez thanks a contract grant within the Paidi 2020 of the EU social fund-University of Seville. We also thank effusively the support of Dr. Pedro E. Sanchez-Jimenez during the thermogravimetric microbalance experiments.
Published: 2022

32. Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 ( WT1 ) gene

Author: Masomeh Askari, Svetlana A. Yatsenko, Robin Lovell-Badge, Tiphanie Merel-Chali, Balázs Gellén, Nitzan Gonen, Leila Fusee, Rana Mainpal, Mariana Costanzo, Inas Mazen, Anu Bashamboo, Anahita Mohseni Meybodi, Esperanza Berensztein, Joelle Bignon-Topalovic, Caroline Eozenou, Natalia Perez Garrido, Alicia Belgorosky, Andrea J. Berman, Roberta Migale, Ken McElreavey, Rita Bertalan, Alaa K. Kamel, Mona K. Mekkawy, Maria Sol Touzon, Priti Singh, Pablo Ramirez, Gabriela Guercio, Aleksandar Rajkovic, Mehdi Totonchi, Selma F. Witchel, Roxana Marino, John C. Schimenti, Anne Jørgensen, Génétique du développement humain, Institut Pasteur [Paris], The Francis Crick Institute [London], The Mina & Everard Goodman Faculty of Life Sciences [Ramat Gan, Israël], Université Bar-Ilan [Israel], Hospital Nacional de Pediatría Prof. Dr Juan P. Garrahan [Buenos Aires], Copenhagen University Hospital, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), National Research Centre - NRC (EGYPT), University of Szeged [Szeged], Cornell University [New York], Children's Hospital of Pittsburgh of UPMC [Etats-Unis], Royan Institute for Reproductive Biomedicine [Tehran, Iran], Semmelweis University [Budapest], University of California, Génétique du Développement humain - Human developmental genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), This work is supported by the European Cooperation in Science and Technology (COST) Action DSDnet BM1303 (to A. Bashamboo and K.M.). N.G and R.L.-B. are funded by the Francis Crick Institute. The Francis Crick Institute receives its core funding from Cancer Research UK Grant FC001107, UK Medical Research Council Grant FC001107, Wellcome Grant FC001107, and by UK Medical Research Council Grant U117512772. M.S.T. and A. Belgorosky are supported by PIDC-20160028 Fondo Nacional de Ciencia y Tecnologia, Argentina, Grant PICT-2013-0181y PICT2016-0214, Agencia Nacional para Ciencia y Tecnologia, Argentina, and Consejo Nacional de Investigaciones Cientificas y Tecnologicas, Argentina. A.R. is funded by NIH Grants R01HD070647 and R21HD074278. A.J. is funded by a research grant from the Svend Andersen Foundation and the Danish Government’s support to Department of Growth and Reproduction for the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC) programme. A.J.B. is supported by NIH Grant GM116889 and American Cancer Society Research Scholar Grant RSG-17-1.97-01-RMC, We are grateful to the Biological Research Facility, Genetic Modification Service, and Experimental Histopathology Facilities of the Francis Crick Institute. We acknowledge Dr. László Tiszlavicz (Pathological Department, University of Szeged, Hungary) for the histological examination of Patients 5a and 5b and Dr. Alejandro Suárez-Bonnet (Experimental Histopathology at Francis Crick Institute) for pathology report on mouse embryonic kidneys., Institut Pasteur [Paris] (IP), Bar-Ilan University [Israël], University of California (UC), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and ANR-17-CE14-0038,MGonDev,Etude des mécanismes du développement des gonades chez l'homme(2017)
Subjects: 0301 basic medicine, Wt1 gene, Gonad, organogenesis, sex determination, 030209 endocrinology & metabolism, Biology, 03 medical and health sciences, 0302 clinical medicine, β-CATENIN, medicine, Gene, Exome sequencing, Zinc finger, Genetics, Multidisciplinary, urogenital system, Wilms' tumor, medicine.disease, XX TDSD/OTDSD, WT1, 030104 developmental biology, medicine.anatomical_structure, Testis determining factor, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Etiology
Abstract: International audience; Sex determination in mammals is governed by antagonistic interactions of two genetic pathways, imbalance in which may lead to disorders/differences of sex development (DSD) in human. Among 46,XX individuals with testicular DSD (TDSD) or ovotesticular DSD (OTDSD), testicular tissue is present in the gonad. Although the testis-determining gene SRY is present in many cases, the etiology is unknown in most SRY-negative patients. We performed exome sequencing on 78 individuals with 46,XX TDSD/OTDSD of unknown genetic etiology and identified seven (8.97%) with heterozygous variants affecting the fourth zinc finger (ZF4) of Wilms' tumor 1 (WT1) (p.Ser478Thrfs*17, p.Pro481Leufs*15, p.Lys491Glu, p.Arg495Gln [x3], p.Arg495Gly). The variants were de novo in six families (P = 4.4 × 10-6), and the incidence of WT1 variants in 46,XX DSD is enriched compared to control populations (P < 1.8 × 10-4). The introduction of ZF4 mutants into a human granulosa cell line resulted in up-regulation of endogenous Sertoli cell transcripts and Wt1 Arg495Gly/Arg495Gly XX mice display masculinization of the fetal gonads. The phenotype could be explained by the ability of the mutated proteins to physically interact with and sequester a key pro-ovary factor β-CATENIN, which may lead to up-regulation of testis-specific pathway. Our data show that unlike previous association of WT1 and 46,XY DSD, ZF4 variants of WT1 are a relatively common cause of 46,XX TDSD/OTDSD. This expands the spectrum of phenotypes associated with WT1 variants and shows that the WT1 protein affecting ZF4 can function as a protestis factor in an XX chromosomal context.
Published: 2020
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33. Role of spin-lattice coupling in ultrafast demagnetization and all optical helicity-independent single-shot switching in Gd1−x−yTbyCox alloys

Author: Wei Zhang, Jun Xiao Lin, Tian Xun Huang, Gregory Malinowski, Michel Hehn, Yong Xu, Stéphane Mangin, Weisheng Zhao, Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Beihang University (BUAA), FEDER-FSE Lorraine et Massif des Vosges 2014-2020, Institut Carnot ICEEL, Région Grand-Est, European Cooperation in Science and Technology (COST), National Natural Science Foundation of China (NSFC, Beihang Hefei Innovation Research Institute Project, ANR-15-IDEX-0004,LUE,Isite LUE(2015), ANR-20-CE09-0013,UFO,OVNI Optique grande Vitesse pour l'électroNIque de spin(2020), and European Project: 793345,H2020-MSCA-IF-2017,ComRad(2018)
Subjects: [PHYS]Physics [physics], [PHYS.PHYS]Physics [physics]/Physics [physics], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat]
Abstract: International audience; All optical switching (AOS) of magnetization exhibits a high potential for ultrafast and energy-efficient memory applications. Many works have been carried out in the area of AOS, including its observation in a wide variety of ferromagnetic or ferrimagnetic materials, and the exploration of the parameters for the achievements of AOS such as the laser fluence and helicity, and duration of laser pulses. A large majority of all optical helicity-independent single-shot switching (AO-HIS) has been observed in Gd-based rare-earth transition-metal ferrimagnets. It is then necessary to explore the unique role of Gd in AO-HIS mechanism, compared with other rare-earth elements. Here, we engineered Gd 1−x−y Tb y Co x alloys and investigated the influence of the Tb concentration on the magnetization dynamics via static Kerr microscope and time-resolved magneto-optical Kerr effect (TR-MOKE) measurements. The ultrafast demagnetization time at low fluence is found to be independent of Tb concentration, while both the range of laser fluence and pulse duration allowing for AO-HIS becomes narrower with increasing the Tb concentration. The TR-MOKE signal K / K_sat ∼ 10 ps after the laser pulse excitation decreases with increasing either the Tb concentration or the pulse duration. The fact that AO-HIS is prohibited by increasing the Tb content is explained by considering a larger damping for Tb than Gd in atomistic simulations. Our results are well explained by the fact that angular momentum can be transferred from Gd to Co resulting in the magnetization switching, whereas for Tb it is dissipated through the lattice due to the large spin-orbit coupling, instead of being transferred between Tb and Co.
Published: 2022
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34. Domain ontologies to explore and manage functional soil-invertebrate diversity

Author: Martínez-Muñoz, C.A., Driller, C., Aldana-Martín, J.F., Hedde, Mickael, Russell, D., Fournier, Dominique, Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Leibniz Association, University of Turku, Universidad de Málaga [Málaga] = University of Málaga [Málaga], Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), project number 326061700, and European Cooperation in Science and Technology (COST), COST Action CA18237.
Subjects: [INFO.INFO-AI] Computer Science [cs]/Artificial Intelligence [cs.AI], [SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, GeneralLiterature_MISCELLANEOUS, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; Due to their high structural and functional diversity, soil invertebrates are crucial for ecosystem functioning and its stability. This diversity is reflected not only in the multitude of quantitative and qualitative studies, but also in the range of existing vocabularies of characters and character states for functional soil biodiversity. Data mining and text mining are increasingly used to scour large data resources and systematically extract relevant information in a machine-based manner. Controlled vocabularies play a central role in applying these methods to represent implicit and explicit knowledge in so-called knowledge graphs in a structured and machine- and human-readable way. The Specialized Information Service Biodiversity Research (BIOfid) aims at this method of data mobilization from Central European biodiversity literature. In cooperation with the European Soil-Biology Data Warehouse for Soil Protection (EUdaphobase), differing vocabularies on the taxonomy, anatomy, ecology and traits of soil invertebrates are currently being harmonized and mapped onto domain-specific ontologies. In addition to data extraction, these ontologies should also support the interoperable and sustainable management of pan-European soil biodiversity data.
Published: 2022

35. Complete Genome Sequence of Xanthomonas campestris pv. campestris SB80, a Race 4 Strain Isolated from White Head Cabbage in Turkey

Author: Erken Meral, Songül, Bibi, Shaheen, Díaz Rodríguez, Carlos Andrés, Menković, Jelena, Bernal, Adriana, Koebnik, Ralf, Black Sea Agricultural Research Institute, Pennsylvania State University (Penn State), Penn State System, Universidad de los Andes [Bogota] (UNIANDES), University of Belgrade [Belgrade], Plant Health Institute of Montpellier (UMR PHIM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Institut de Recherche pour le Développement, France, for supporting the North-South-South Network on Xanthomonads (NSSN-X) within the International Scientific Coordination Network—South (GDRI-Sud), European Cooperation in Science and Technology (COST) program for support of the EuroXanth COST Action CA16107, and Ministry of Education, Science and Technological Development, Republic of Serbia, and Faculty of Agriculture contract number 451-03-9/2021-14/200116.
Subjects: [SDV]Life Sciences [q-bio]
Abstract: International audience; Here, we report the complete genome sequence of the race 4 strain Xanthomonas campestris pv. campestris SB80, which was isolated from a symptomatic white head cabbage leaf in Samsun Province, Turkey, in 2019. The genome consists of a circular chromosome (5,129,762 bp) with a G+C content of 64.98%, for which 4,159 putative protein-coding genes, 2 rRNA operons, 54 tRNAs, and 86 noncoding RNAs (ncRNAs) were predicted.
Published: 2022
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36. Rheological properties of artificial boluses of cereal foods enriched with legume proteins

Author: R.G.M. van der Sman, G. Della Valle, Jose Benedito, F. Gibouin, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Wageningen University and Research [Wageningen] (WUR), Universitat Politècnica de València (UPV), Region Pays de la Loire, European Commission, and European Cooperation in Science and Technology (COST) : CA15118-Mathematical.
Subjects: Materials science, 030309 nutrition & dietetics, Starch, General Chemical Engineering, Viscosity, Viscoelasticity, Interaction coefficient, Plant protein, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, food, Rheology, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Shear stress, Composite material, Modulus, VLAG, 2. Zero hunger, 0303 health sciences, Rheometry, 04 agricultural and veterinary sciences, General Chemistry, Sponge cake, 040401 food science, food.food, chemistry, Herschel-bulkley model, Food Technology, Food Science
Abstract: International audience; The properties of artificial food bolus are studied by dynamic oscillatory and capillary rheometry as functions of bolus water content (WC), in the usual range of saliva hydration, for four cereal products: sponge cake, extruded flat bread and their counterpart enriched in legume proteins. All boluses followed the same rheological behavior characterized by (1) solid -like in the linear viscoelastic domain and (2) Herschel-Bulkley model for large shear strain. Hence, four characteristic rheological properties are determined: modulus at viscoelastic plateau, characteristic stress at transition to flow, yield stress and consistency in the flow regime. The decrease of these properties with WC was fitted by an exponential decay function, from which was extracted a coefficient alpha (5 = alpha < 30), defined as a coefficient of interaction of the food with water. The values of alpha are of the same order of magnitude as the plasticization coefficient of starch by water. They were larger for the extruded pea based (EFP, alpha >= 15), and were lower for the sponge cake (SC, alpha < 15). The variations for the different rheological properties are discussed in terms of matter state, envisioning bolus as a suspension of soft swellable particles. The comparison of these values with those encountered for real boluses from similar foods suggests that these results contribute to define a coefficient of interaction of food with saliva.
Published: 2022
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37. Collisional line-shape effects in accurate He-perturbed H-2 spectra

Author: Samir Kassi, Hubert Jóźwiak, Michał Słowiński, Franck Thibault, Piotr S. Żuchowski, Shui-Ming Hu, An-Wen Liu, Maciej Gancewski, Nikodem Stolarczyk, Jin Wang, Piotr Wcisło, Yan Tan, Alain Campargue, Roman Ciuryło, Konrad Patkowski, Kamil Stankiewicz, Nicolaus Copernicus University [Toruń], University of Science and Technology of China [Hefei] (USTC), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Auburn University (AU), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), A next-generation worldwide quantum sensor network with optical atomic clocks project carried out within the TEAM IV Programme of the Foundation for Polish Science - European Union under the European Regional Development Fund, National Science Centre, PolandNational Science Centre, Poland [2018/31/B/ST2/00720, 2019/35/B/ST2/01118], National Natural Science Foundation of China National Natural Science Foundation of China (NSFC) [21688102], Agence Nationale de la Recherche French National Research Agency (ANR)European Commission [Equipex REFIMEVE ANR-11-EQPX-0 039], U.S. National Science FoundationNational Science Foundation (NSF) [CHE-1955328], Polish National Agency for Academic Exchange under the PHC Polonium program Polish National Agency for Academic Exchange (NAWA) [dec. PPN/X/PS/318/2018], COST Action European Cooperation in Science and Technology (COST) [CM1405 MOLIM], ANR-11-EQPX-0039,REFIMEVE+,RESEAU FIBRE METROLOGIQUE A VOCATION EUROPEENNE +(2011), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics, [PHYS]Physics [physics], Radiation, 010304 chemical physics, Dicke effect, chemistry.chemical_element, 01 natural sciences, Atomic and Molecular Physics, and Optics, Spectral line, Molecular hydrogen, chemistry, Distortion, 0103 physical sciences, Spectral line shape, Atomic and molecular collisions, Atomic physics, Hydrogen absorption, Quantum dynamics, 010306 general physics, Collisional line-shape effects, Molecular physics, ab initio quantum-scattering Calculations, Spectroscopy, Helium, Line (formation)
Abstract: International audience; We investigate collisional line-shape effects that are present in highly accurate experimental spectra of the 3-0 S(1) and 2-0 Q(1) molecular hydrogen absorption lines perturbed by helium. We clearly distin-guish the influence of six different collisional effects (i.e.: collisional broadening and shift, their speed dependencies and the complex Dicke effect) on the shapes of H-2 lines. We demonstrate that only a very specific combination of these six contributions, determined from our ab initio calculations, gives unprece-dentedly good agreement with experimental spectra. If any of the six contributions is neglected, then the experiment-theory comparison deteriorates at least several times. We also analyze the influence of the centrifugal distortion on our ab initio calculations and we demonstrate that the inclusion of this effect slightly improves the agreement with the experimental spectra. (C) 2021 The Author(s). Published by Elsevier Ltd.
Published: 2022
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38. Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides

Author: Ignacio Rodríguez‐Izquierdo, Daniel Sepúlveda‐Crespo, Jose María Lasso, Salvador Resino, Ma Ángeles Muñoz‐Fernández, Instituto de Salud Carlos III, Plan Nacional de I+D+i (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Ministerio de Economía y Competitividad (España), Gordon and Betty Moore Foundation, Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), and Unión Europea. European Cooperation in Science and Technology (COST)
Subjects: Dendrimers, Dendrimer, Biomedical Engineering, Vaginal microbicide, Medicine (miscellaneous), Bioengineering, HIV Infections, Acceptability, Preclinical steps, Anti-Infective Agents, Anti-Infective Agents, Local, HIV-1, Humans, Female, Regulation
Abstract: Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1) in human clinical trials. In vitro, ex vivo, and in vivo models must be optimized, considering the knowledge acquired from unsuccessful and successful clinical trials to improve the current gaps and the preclinical development protocols. To date, dendrimers are the only nanotool that has advanced to human clinical trials as topical microbicides to prevent HIV-1 transmission. This fact demonstrates the importance and the potential of these molecules as microbicides. Polyanionic dendrimers are highly branched nanocompounds with potent activity against HIV-1 that disturb HIV-1 entry. Herein, the most significant advancements in topical microbicide development, trying to mimic the real-life conditions as closely as possible, are discussed. This review also provides the preclinical assays that anionic dendrimers have passed as microbicides because they can improve current antiviral treatments' efficacy. This work has been (partially) funded by the RD16/0025/0019 projects as part of Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (2013–2016) and cofinanced by Instituto de Salud Carlos III (ISCIII) and Fondo Europeo de Desarrollo Regional (FEDER), RETIC PT17/0015/0042, Fondo de Investigacion Sanitaria (FIS) (grant no. PI16/01863) and EPIICAL project. COST CA17140 Cancer Nanomedicine-“From the Bench to Bedside.” This work has also been supported by the Ministry of Economy and Competitiveness #CGL2013-40564-R and Gordon and Betty Moore Foundation grant no. 5334. This work was also funded by research grants from ISCIII (grant numbers PI20CIII/00004, and RD16CIII/0002/0002) to Salvador Resino. The study was also funded by the Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CB21/13/00044). DS-C is a “Sara Borrell” researcher from ISCIII (grant no. CD20CIII/00001). Sí
Published: 2021

39. Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources

Author: Giuseppina Schiavo, Valeria Taurisano, Raquel Quintanilla, Anisa Ribani, Juan García-Casco, Rui Charneca, Valerio Joe Utzeri, Marie-José Mercat, Estefania Alves, Fabián García, Graham J Etherington, Samuele Bovo, Juliette Riquet, Danijel Karolyi, Christoph Zimmer, Ivona Djurkin Kušec, Federica Di Palma, Ana Isabel Fernández, G. Usai, Violeta Razmaite, María Muñoz, Yolanda Núñez, José Pedro Araújo, Martin Škrlep, Radomir Savić, J.M. Martins, Maurizio Gallo, Luca Fontanesi, Čedomir Radović, Mohamad Ballan, Cristina Óvilo, Riccardo Bozzi, University of Bologna, Instituto Nacional de Investigación Agropecuaria (INIA), Centro de Investigação de Montanha [Bragança, Portugal] (CIMO), Instituto Politécnico de Bragança, Department of Agriculture, Food, Environment and Forestry (DAGRI), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Universidade de Évora, University of East Anglia [Norwich] (UEA), Josip Juraj Strossmayer University of Osijek, Earlham Institute [Norwich], University of Zagreb, Associazione Nazionale Allevatori Suini, Institut du Porc (IFIP), Institute of Agrifood Research and Technology (IRTA), Institute for Animal Husbandry, Lithuanian University of Health Sciences [Kaunas, Lithuania], Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Belgrade [Belgrade], Kmetijski Inštitut Slovenije (KIS), AGRIS sardegna, Bäuerliche Erzeugergemeinschaft Schwäbisch Hall (BESH), European Cooperation in Science and Technology (COST)Ministry of Foreign Affairs of ItalyUniversity of Bologna RFO 2016-2019 programmesItalian MIUR 2017 PigPhenomics projectEuropean Commission634476European Open Science Cloud (EOSC) Secretariat, project 'Application of animal genomics and data mining to predict and monitor novel coronavirus potential infections (VirAnimalOne)'EGI call for COVID-19 research projects (AnGen1H project)Por Fesr Emilia-Romagna 2014-2020 (actions 1.1.4 and 1.2.2-Bando per sostenere progetti di ricerca ed innovazione per lo sviluppo di soluzioni finalizzate al contrasto dell'epidemia da COVID-19-Project LIVESTOCK-STOP-COVI), European Project: 634476,H2020,H2020-SFS-2014-2,TREASURE(2015), Producció Animal, Genètica i Millora Animal, University of Bologna/Università di Bologna, Università degli Studi di Firenze = University of Florence (UniFI), Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università di Bologna, European Commission, Bovo, Samuele, Schiavo, Giuseppina, Ribani, Anisa, Utzeri, Valerio J, Taurisano, Valeria, Araujo, Jose P, Bozzi, Riccardo, Charneca, Rui, Di Palma, Federica, Djurkin Kušec, Ivona, Etherington, Graham, Fernandez, Ana I, Suárez García, Fabián, García-Casco, Juan, Karolyi, D 0000-003-0409-9071], Martins, José Manuel, Mercat, Marie-José, Núñez, Yolanda, Radović, Čedomir, Razmaite, Violeta, Riquet, Juliette, Savić, Radomir, Škrlep, Martin, Usai, Graziano, Ovilo, Cristina, Bovo S., Schiavo G., Ribani A., Utzeri V.J., Taurisano V., Ballan M., Munoz M., Alves E., Araujo J.P., Bozzi R., Charneca R., Di Palma F., Djurkin Kusec I., Etherington G., Fernandez A.I., Garcia F., Garcia-Casco J., Karolyi D., Gallo M., Martins J.M., Mercat M.-J., Nunez Y., Quintanilla R., Radovic C., Razmaite V., Riquet J., Savic R., Skrlep M., Usai G., Zimmer C., Ovilo C., and Fontanesi L.
Subjects: 0301 basic medicine, Candidate gene, Population genetics, Swine, MESH: Coronavirus Infections, Sus scrofa, MESH: Angiotensin-Converting Enzyme 2, MESH: One Health, Breeding, MESH: INDEL Mutation, 0302 clinical medicine, Gene Frequency, INDEL Mutation, Receptors, Receptors, Viru, MESH: Animals, MESH: Serine Endopeptidases, MESH: Genetic Variation, MESH: High-Throughput Nucleotide Sequencing, MESH: Swine, 2. Zero hunger, Genetics, education.field_of_study, Multidisciplinary, MESH: Polymorphism, Single Nucleotide, Serine Endopeptidases, High-Throughput Nucleotide Sequencing, Single Nucleotide, Genomics, Virus, Serine Endopeptidase, One Health, 030220 oncology & carcinogenesis, Microsomal aminopeptidase, Medicine, Infectious diseases, Receptors, Virus, Angiotensin-Converting Enzyme 2, Coronavirus Infections, MESH: Whole Genome Sequencing, Human, Agricultural genetics, pig, local breed, whole genome sequencing, coronavirus, Science, Dipeptidyl Peptidase 4, Population, MESH: Genetics, Population, Context (language use), MESH: Breeding, CD13 Antigens, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Animals, Genetics, Population, Humans, Whole Genome Sequencing, Genetic Variation, Genetic variation, MESH: Gene Frequency, Polymorphism, education, Data mining, Gene, CD13 Antigen, Animal breeding, Whole genome sequencing, MESH: Humans, Animal, Coronavirus Infection, Host (biology), Virus receptor, MESH: CD13 Antigens, MESH: Dipeptidyl Peptidase 4, MESH: Receptors, Virus, MESH: Sus scrofa, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, 030104 developmental biology, Dipeptidyl peptidase IV, Next-generation sequencing, Genetic markers, Serine proteinase
Abstract: 14 Pág. Departamento de Mejora Genética Animal, Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a "One Health" perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a "One Health" perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources., This work has received funding from the University of Bologna RFO 2016-2019 programmes, the Italian MIUR 2017 PigPhenomics project, from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 634476 for the project with acronym TREASURE, from the European Open Science Cloud (EOSC) Secretariat, project “Application of animal genomics and data mining to predict and monitor novel coronavirus potential infections (VirAnimalOne)”, the EGI call for COVID-19 research projects (AnGen1H project) and from the Por Fesr Emilia-Romagna 2014-2020 (actions 1.1.4 and 1.2.2—Bando per sostenere progetti di ricerca ed innovazione per lo sviluppo di soluzioni finalizzate al contrasto dell’epidemia da COVID-19—Project LIVESTOCK-STOP-COVI). The content of this article reflects only the authors' view and the European Union Agency is not responsible for any use that may be made of the information it contains.
Published: 2021
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40. A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells

Author: Cristina de la Torre, Pablo Játiva, Inmaculada Posadas, Darío Manzanares, José L. Jiménez Blanco, Carmen Ortiz Mellet, José Manuel García Fernández, Valentín Ceña, Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Agencia Estatal de Investigación. España, Instituto de Salud Carlos III, Euronanomed Program, Junta de Castilla-La Mancha, Junta de Andalucía, European Cooperation in Science and Technology (COST), and European Regional Development Fund
Subjects: β-cyclodextrin, glioblastoma, prostate cancer, siRNA, p42-MAPK, Rheb, Prostate cancer, Pharmaceutical Science, Glioblastoma
Abstract: Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a high degree of specificity, leading to selective knockdown of the proteins they encode. However, siRNAs are very labile and must be both protected and transported by nanoparticles to be efficiently delivered into cells. In this work, we used a Janus-type polycationic amphiphilic β-cyclodextrin derivative to efficiently transfect siRNAs targeting mRNAs encoding mitogen-activated protein kinase (p42-MAPK) or Ras homolog enriched in brain (Rheb) into different cancer cell lines as well as astrocytes. We took advantage of this high transfection efficiency to simultaneously knock down p42-MAPK and Rheb to boost docetaxel (DTX)-mediated toxicity in two human prostate cancer cell lines (LNCaP and PC3). We found that double knockdown of p42-MAPK and Rheb increased DTX-toxicity in LNCaP but not in PC3 cells. However, we also observed the same effect when scramble siRNA was used, therefore pointing to an off-target effect. Indeed, we found that the siRNA we used in this work induced toll-like receptor 3 activation, leading to β-interferon production and caspase activation. We believe that this mechanism could be very useful as a general strategy to elicit an immune response against prostate cancer cells. Instituto de Salud Carlos III AC19/00075 Junta de Castilla-La Mancha SBPLY/19/180501/000067 European Cooperation in Science and Technology CA17140 Junta de Andalucía P20_00166 Ministerio de Ciencia e Innovación PID2020-120134RB-I00, RTI2018-097609-B-C21, PID2021-124247OB-C21, PID2019-105858RB-I00 ERANET NANO4GLIO
Published: 2022
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41. Beyond Experiments:Embedding outcomes in climate governance

Author: Sengers, F., Turnheim, Bruno, Berkhout, Frans, Innovation and Sustainability, Innovation Studies, Utrecht University [Utrecht], Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés (LISIS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Gustave Eiffel, King‘s College London, European Cooperation in Science and Technology (COST)IS1309French National Research Agency (ANR)ANR-19-MPGA-0010, ANR-19-MPGA-0010,WAYS-OUT,Governing destabilisation pathWAYS and Phase-OUT: Pluralising knowledge in support of deliberate low-carbon transitions governance ans strategies(2019), Innovation and Sustainability, and Innovation Studies
Subjects: Sociotechnical system, Public Administration, Monitoring, Geography, Planning and Development, 0211 other engineering and technologies, climate governance, Climate change, Public policy, 02 engineering and technology, Management, Monitoring, Policy and Law, Environmental Science (miscellaneous), sustainability transitions, socio-technical systems, 12. Responsible consumption, 11. Sustainability, 050602 political science & public administration, Socio-technical systems, Planning and Development, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Climate governance, Geography, Policy and Law, 05 social sciences, 021107 urban & regional planning, 0506 political science, Management, Action (philosophy), 13. Climate action, Sustainability transitions, Embedding, Business, Economic system, Experiments
Abstract: International audience; Concerted action on climate change will require a continuing stream of social and technical innovations whose development and transmission will be influenced by public policies. New ways of doing things frequently emerge in innovative small-scale initiatives – ‘experiments’ – across sectors of economic and social life. These experiments are actionable expressions of novel governance and socio-technical arrangements. Mobilising and generalising the outputs of these experiments could lead to deep reductions in greenhouse gas emissions over the long-term. It is often assumed that the groundswell of socio-technical and governance experiments will ‘scale-up’ to systemic change. But the mechanisms for these wider, transformative impacts of experiments have not been fully conceptualised and explained. This paper proposes a conceptual framework for the mobilisation, generalisation and embedding of the outputs and outcomes of climate governance experiments. We describe and illustrate four ‘embedding mechanisms’ – (1) replication-proliferation; (2) expansion-consolidation; (3) challenging-reframing; and (4) circulation-anchoring – for entwined governance and socio-technical experiments. Through these mechanisms knowledge, capabilities, norms and networks developed by experiments become mobile and generic, and come to be embedded in reconfigured socio-technical and governance systems.
Published: 2021
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42. A survey of challenges for runtime verification from advanced application domains (beyond software)

Author: Wolfgang Ahrendt, Domenico Bianculli, Srđan Krstić, Christian Colombo, Gerardo Schneider, Julien Signoles, Dmitriy Traytel, João Lourenço, Yliès Falcone, José Rufino, Gordon J. Pace, Adrian Francalanza, Alexander Weiss, César Sánchez, Dejan Nickovic, Ezio Bartocci, Institute IMDEA Software [Madrid], University of Gothenburg (GU), Chalmers University of Technology [Göteborg], Vienna University of Technology (TU Wien), Université du Luxembourg (Uni.lu), University of Malta [Malta], Université Grenoble Alpes - UFR Informatique et Mathématiques Appliquées (UGA UFR IMAG), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Compiler Optimization and Run-time Systems (CORSE), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Department of Computer Science [ETH Zürich] (D-INFK), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Austrian Institute of Technology [Vienna] (AIT), Department of Computer Science [Malta], Laboratoire Sûreté des Logiciels (LSL), Département Ingénierie Logiciels et Systèmes (DILS), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Accemic Technologies GmbH, DI - Departamento de Informática, NOVALincs, European Cooperation in Science and Technology (COST) [sponsor], Interdisciplinary Centre for Security, Reliability and Trust (SnT) > Software Verification and Validation Lab (SVV Lab) [research center], Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), and University of Edinburgh
Subjects: FOS: Computer and information sciences, Computer science, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], 02 engineering and technology, Runtime verification, Formal methods, Formal verification, Theoretical Computer Science, Computer Science - Software Engineering, Software, Computer software -- Verification, Formal specification, 0202 electrical engineering, electronic engineering, information engineering, Instrumentation (computer programming), TRACE (psycholinguistics), Formal methods (Computer science), Computer science [C05] [Engineering, computing & technology], Computational model, business.industry, 020207 software engineering, Sciences informatiques [C05] [Ingénierie, informatique & technologie], Software Engineering (cs.SE), Hardware and Architecture, [INFO.INFO-ES]Computer Science [cs]/Embedded Systems, 020201 artificial intelligence & image processing, Software engineering, business
Abstract: Runtime verification is an area of formal methods that studies the dynamic analysis of execution traces against formal specifications. Typically, the two main activities in runtime verification efforts are the process of creating monitors from specifications, and the algorithms for the evaluation of traces against the generated monitors. Other activities involve the instrumentation of the system to generate the trace and the communication between the system under analysis and the monitor. Most of the applications in runtime verification have been focused on the dynamic analysis of software, even though there are many more potential applications to other computational devices and target systems. In this paper we present a collection of challenges for runtime verification extracted from concrete application domains, focusing on the difficulties that must be overcome to tackle these specific challenges. The computational models that characterize these domains require to devise new techniques beyond the current state of the art in runtime verification., Formal Methods in System Design, 54 (3), ISSN:0925-9856, ISSN:1572-8102
Published: 2019
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43. Lamin A/C deficiency in CD4 + T‐cells enhances regulatory T‐cells and prevents inflammatory bowel disease

Author: Francisco Sánchez-Madrid, Virginia Zorita, Philippe Collas, José L. Pablos, Juan Antonio López, José María González-Granado, Gabriel Criado, Jesús Vázquez, Raquel Toribio-Fernández, Vicente Andrés, Beatriz Herrero-Fernandez, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), The Research Council of Norway, European Research Council, Unión Europea. European Cooperation in Science and Technology (COST), Ministerio de Ciencia, Innovación y Universidades (España), Centro de Investigación Biomedica en Red - CIBER, Fundación ProCNIC, Fundación Ramón Areces, Autonomous University of Madrid (España), and Research Institute Hospital 12 de Octubre
Subjects: 0301 basic medicine, Adoptive cell transfer, FOXP3, Regulatory T cell, Regulator, Retinoic acid, chemical and pharmacologic phenomena, Biology, CD4+ T-cells, Inflammatory bowel disease, Pathology and Forensic Medicine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Mesenteric lymph nodes, Epigenetics, Lamin A/C, hemic and immune systems, 3. Good health, Regulatory T-cell, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Cancer research, Lamin
Abstract: The mechanisms by which lamin A/C in CD4+ T-cells control intestinal homeostasis and can cause inflammatory bowel disease (IBD) are unknown. Here, we explore lamin A/C in a mouse model of IBD. Adoptive transfer to Rag1-/- mice of Lmna-/- CD4+ T-cells, which have enhanced regulatory T-cells (Treg) differentiation and function, induced less severe IBD than wild-type T-cells. Lamin A/C deficiency in CD4+ T-cells enhanced transcription of the Treg master regulator FOXP3, thus promoting Treg differentiation, and reduced Th1 polarization, due to epigenetic changes in the Th1 master regulator T-bet. In mesenteric lymph nodes, retinoic acid (RA) released by CD103+ dendritic cells downregulated lamin A/C in CD4+ T-cells, enhancing Treg differentiation. However, non-RA-producing CD103- dendritic cells predominated in peripheral lymph nodes, facilitating lamin A/C expression in CD4+ T-cells and therefore Th1 differentiation. Our findings establish lamin A/C as a key regulator of Th differentiation in physiological conditions and show it as a potential immune-regulatory target in IBD. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. This study was supported by grants to PC from the Research Council of Norway, to JMG-G from ISCIII (PI14/00526; PI17/01395; CP11/00145; CPII16/00022; EuroCellNet COST Action CA15214), the Miguel Servet Program and Fundación Ramón Aréces; to VA (RD12/0042/0028 SAF2013-46663-R, SAF2016-79490-R); to FS-M (SAF2017-82886-R; ERC-2011-AdG 294340-GENTRIS, CIBER CARDIOVASCULAR, PIE 13.0004-BIOIMID and CAM-B2017/BMD-3671-INFLAMUNE), to GC and JLP (PI16/00032 and RETICs RD16/0012 RIER), and to JV (BIO2015-67580-P; PRB3, IPT17/0019 - ISCIII-SGEFI/ERDF, ProteoRed) with co-funding from the European Regional Development Fund (ERDF) “Una manera de hacer Europa”. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCNU) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). RTF is supported by the Fundación Ramón Aréces, VZG by ISCIII, BHF by the Instituto de Investigación Hospital 12 de Octubre (i+12), and JMG-G by the ISCIII Miguel Servet Program, i+12 and Universidad Autónoma de Madrid (UAM). Sí
Published: 2019
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44. Contribution of plant food bioactives in promoting health effects of plant foods: why look at interindividual variability?

Author: Francisco A. Tomás-Barberán, Christine Morand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Consejo Superior de Investigaciones Científicas (Spain) (CSIC), European Cooperation in Science and Technology (COST) FA1403, Unité de Nutrition Humaine (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
Subjects: 0301 basic medicine, Phytochemicals, Medicine (miscellaneous), Review, Health Promotion, Biology, Plant foods, Interindividual variability, 03 medical and health sciences, Humans, 2. Zero hunger, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Diet, Vegetarian, fungi, digestive, oral, and skin physiology, Human nutrition, Cardiometabolic health, food and beverages, Food phytochemicals, Personalised nutrition, 3. Good health, Biotechnology, 030104 developmental biology, Biological Variation, Population, Plants, Edible, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Purpose Research has identified plant-based diets as the most protective for our health; it is now essential to focus on good food associations and the beneficial constituents in plant foods. From a growing body of evidence, some categories of food phytochemicals are increasingly considered to play a crucial role in the cardiometabolic health effects associated with plant food consumption. However, the heterogeneity in responsiveness to plant food bioactive intake that is frequently observed in clinical trials can hinder the identification of the effects of these compounds in specific subpopulations and likely lead to underestimating their actual contribution to the health effects of their food sources. Results The magnitude and the main factors responsible for this between-subject variation in response to the consumption of the major families of food phytochemicals have been poorly documented so far. Thus, research efforts in this area must be developed. More importantly, capturing the interindividual variability in response to plant food bioactive intake, together with identifying the main determinants involved, is a crucial step that will enable the development and production of plant food products, thereby satisfying the nutritional needs and conferring benefits to different categories of populations. Conclusion The development of a science-based personalised nutrition approach focusing on plant foods rich in specific bioactive compounds could contribute to alleviating the dramatic burden of metabolic and cardiovascular diseases., Key messages Plant food bioactives represent a tremendous potential for innovation in the field of food, nutrition, and health.The role of phytochemicals in the health benefits of plant-based foods has been underestimated so far.A full consideration of plant food bioactives in future preventive strategies implies research that tackles the factors responsible for interindividual variability.A better understanding of interindividual variability in response to plant food bioactives is needed to:Refine dietary recommendations towards foods that are particularly rich in specific bioactives.Broaden perspectives for the food industry to develop strategies for future personalised food products targeted to specific consumer groups.
Published: 2019
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45. Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice

Author: Christian Weber, María J. Andrés-Manzano, Ziad Mallat, Leonor Kremer, Virginia Zorita, Julio Gutiérrez, José María González-Granado, Carlos Silvestre-Roig, Yafa Naim Abu Nabah, Hafid Ait-Oufella, Vicente Andrés, Marian Vila-Caballer, Alberto del Monte-Monge, Pedro Molina-Sánchez, María José Sanz, Instituto de Salud Carlos III, European Research Council, Ministerio de Ciencia, Innovación y Universidades (España), British Heart Foundation, Fundación Ramón Areces, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Unión Europea. European Cooperation in Science and Technology (COST), and Fundación ProCNIC
Subjects: 0301 basic medicine, Apolipoprotein E, medicine.medical_specialty, Regulatory T cell, CCL1, 030204 cardiovascular system & hematology, CCR8, T-Lymphocytes, Regulatory, Receptors, CCR8, Chemokine CCL1, Mice, 03 medical and health sciences, Apolipoproteins E, Th2 Cells, 0302 clinical medicine, Internal medicine, Leukocytes, medicine, Splenocyte, Animals, Molecular Biology, Inflammation, Mice, Knockout, Chemistry, Th1 Cells, Atherosclerosis, Interleukin-10, Mice, Inbred C57BL, Treg, Interleukin 10, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, IL-10, Cytokines, Cardiology and Cardiovascular Medicine, Intravital microscopy, Lipoprotein
Abstract: The CC chemokine 1 (CCL1, also called I-309 or TCA3) is a potent chemoattractant for leukocytes that plays an important role in inflammatory processes and diseases through binding to its receptor CCR8. Here, we investigated the role of the CCL1-CCR8 axis in atherosclerosis. We found increased expression of CCL1 in the aortas of atherosclerosis-prone fat-fed apolipoprotein E (Apoe)-null mice; moreover, in vitro flow chamber assays and in vivo intravital microscopy demonstrated an essential role for CCL1 in leukocyte recruitment. Mice doubly deficient for CCL1 and Apoe exhibited enhanced atherosclerosis in aorta, which was associated with reduced plasma levels of the anti-inflammatory interleukin 10, an increased splenocyte Th1/Th2 ratio, and a reduced regulatory T cell (Treg) content in aorta and spleen. Reduced Treg recruitment and aggravated atherosclerosis were also detected in the aortas of fat-fed low-density lipoprotein receptor-null mice treated with CCR8 blocking antibodies. These findings demonstrate that disruption of the CCL1-CCR8 axis promotes atherosclerosis by inhibiting interleukin 10 production and Treg recruitment and function., This study was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (MCIU, grants SAF2016-79490-R and SAF2014-57845-R) and the Instituto de Salud Carlos III (ISCIII, grants PI14/00526, PI17/01395, CP11/00145, and CPII16/00022) with co-funding from the European Regional Development Fund (ERDF, “Una manera de hacer Europa”), the Fundación Ramón Areces, European Union (EuroCellNet COST Action CA15214) and the INSERM. VZG is supported by the ISCIII, JMG-G by the ISCIII Miguel Servet Program and the Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), AdMM by the MCIU (predoctoral contract BES-2014-06779), and ZM by a British Heart Foundation Professorship. The CNIC is supported by the MCIU and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).
Published: 2019
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46. A classification approach to reconstruct local daily drying dynamics at headwater streams

Author: Eric Sauquet, Aurélien Beaufort, Julie Carreau, Hydrosciences Montpellier (HSM), Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), RiverLy (UR Riverly), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), French Agency for Biodiversity (AFB), European Cooperation in Science and Technology (COST) CA15113, and Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: flow state, 010504 meteorology & atmospheric sciences, INTERMITTENT RIVERS, 0207 environmental engineering, 02 engineering and technology, STREAMS, 01 natural sciences, LEAST ABSOLUTE SHRINKAGE AND SELECTION OPERATOR, 020701 environmental engineering, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Water Science and Technology, Hydrology, Artificial neural network, RANDOM FOREST, Dynamics (mechanics), 15. Life on land, 6. Clean water, Random forest, drying prediction, [STAT]Statistics [stat], 13. Climate action, ARTIFICIAL NEURAL NETWORK, [SDE]Environmental Sciences, FLOW STATE, Environmental science, DRYING PREDICTION, intermittent rivers, least absolute shrinkage and selection operator, artificial neural network, random forest
Abstract: Headwater streams (HSs) are generally naturally prone to flow intermittence. These intermittent rivers and ephemeral streams have recently seen a marked increase in interest, especially to assess the impact of drying on aquatic ecosystems. The two objectives of this work are (a) to identify the main drivers of flow intermittence dynamics in HS and (b) to reconstruct local daily drying dynamics. Discrete flow states-"flowing" versus "drying"-are modelled as functions of covariates that include information on climate, hydrology, groundwater, and basin descriptors. Three classifiers to estimate flow states using covariates are tested on four contrasted regions in France: (a) a linear classifier with regularization (LASSO for least absolute shrinkage and selection operator) and two non-linear non-parametric classifiers, (b) a one-hidden-layer feedforward artificial neural network (ANN) classifier, and (c) a random forest (RF) classifier. The three classifiers are compared with a benchmark classifier (BC) that simply estimates dominant flow state for each month based on observations (without using covariates). The performance assessment over the period 2012-2016 carried out by cross-validation shows that the three classifiers for flow state based on covariates outperformed the BC. This demonstrates the predictive power of the covariates. ANN is the classifier that globally achieves the best performance to predict the daily drying dynamics whereas both RF and LASSO tend to underestimate the proportion of drying states. The covariates are ranked in terms of relevance for each classifier. The monthly proportion of drying states provided by the discrete observation network has a major importance for the three classifiers ANN, LASSO, and RF. This may reflect the proclivity of a site to flow intermittence. ANN gives higher importance to climatic and hydrological covariates and its non-linearity allows a greater degree of freedom.
Published: 2019
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47. Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice

Author: Rosa Rodriguez-Fernández, María Jesús Serramía, Ignacio Rodriguez-Izquierdo, Mariángeles Muñoz-Fernández, Rafael Ceña-Diez, Isidoro Martínez, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Centro de Investigación Biomédica en Red - CIBERBBN (Bioingeniería, Biomateriales y Nanomedicina), Unión Europea. European Cooperation in Science and Technology (COST), and Polish National Agency for Academic Exchange
Subjects: Polymers and Plastics, viruses, Organic chemistry, 02 engineering and technology, Syncytium, Article, Virus, 03 medical and health sciences, QD241-441, In vivo, Dendrimer, Nanotechnology, Receptor, RSV infection, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, nanotechnology, Chemistry, Respiratory infection, General Chemistry, respiratory system, 021001 nanoscience & nanotechnology, Virology, In vitro, G2-S16 dendrimer, 0210 nano-technology, Glycoprotein, syncytium
Abstract: The respiratory syncytial virus (RSV) causes respiratory infection and bronchiolitis, requiring hospitalization mainly in infants. The interaction between RSV, envelope glycoproteins G and F, and cell surface heparan sulfate proteoglycans (HSPG) is required for binding and entry into the host cells. A G2-S16 polyanionic carbosilane dendrimer was identified as a possible RSV inhibitor. We speculated that the G2-S16 dendrimer adheres to the host cell-surface HSPG, acts through binding to HS receptors, and prevents further RSV infection. The G2-S16 dendrimer was non-toxic when applied intranasally to Balb/c mice, and interestingly enough, this G2-S16 dendrimer inhibits 85% RSV. Therefore, our G2-S16 dendrimer could be a candidate for developing a new possible therapy against RSV infection. This work has been (partially) funded by the RD16/0025/0019, projects as part of Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (2013–2016) and co-financed by Instituto de Salud Carlos III (Subdirección General de Evaluación) and Fondo Europeo de Desarrollo Regional (FEDER), RETIC PT17/0015/0042, Fondo de Investigacion Sanitaria (FIS) (grant number PI19/01638) and EPIICAL project. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, the Consolider Program, and CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This work has been supported partially by the EUROPARTNER: Strengthening and spreading international partnership activities of the Faculty of Biology and Environmental Protection for interdisciplinary research and innovation of the University of Lodz Programme: NAWA International Academic Partnership Programme. This article/publication is based upon work from COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside” supported by COST (European Cooperation in Science and Technology). Sí
Published: 2021

48. Climate mitigation in the Mediterranean Europe: An assessment of regional and city-level plans

Author: Sofia Simoes, Oliver Heidrich, Davide Geneletti, Monica Salvia, Filomena Pietrapertosa, Diana Reckien, Marko Matosović, Vincent Viguié, Léa Tardieu, Nataša Belšak Šel, Efren Feliu, Alexandros Flamos, Sonia De Gregorio Hurtado, Marta Olazabal, Byron Ioannou, Paris A. Fokaides, Niki Artemis Spyridaki, Mario V. Balzan, Klavdija Rižnar, Institute of Methodologies for Environmental Analysis of the National Research Council (IMAA), Consiglio Nazionale delle Ricerche [Roma] (CNR), University of the Basque Country [Bizkaia] (UPV/EHU), Frederick University, Territoires, Environnement, Télédétection et Information Spatiale (UMR TETIS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Cooperation in Science and Technology (COST) - TU0902, Spanish State Research Agency through Maria de Maeztu Excellence Unit accreditation - MDM-20170714, Basque Government, Ministry of Education, Universities and Research (MIUR) - 232/2016, UT-I-ITC-PLUS, Faculty of Geo-Information Science and Earth Observation, Department of Urban and Regional Planning and Geo-Information Management, and Department of Earth Systems Analysis
Subjects: Mediterranean climate, Paris, Environmental Engineering, Croatia, Climate Change, Slovenia, 0208 environmental biotechnology, Climate mitigation, UT-Hybrid-D, Climate change, 02 engineering and technology, 010501 environmental sciences, Management, Monitoring, Policy and Law, 01 natural sciences, 7. Clean energy, 12. Responsible consumption, Climate change mitigation, 11. Sustainability, Region, Cities, Waste Management and Disposal, Environmental planning, 0105 earth and related environmental sciences, Greece, Portugal, Mediterranean Region, Population size, City, 1. No poverty, General Medicine, Mediterranean Europe, 020801 environmental engineering, Local mitigation planning, Europe, Regions, Geography, Italy, Spain, 13. Climate action, ITC-ISI-JOURNAL-ARTICLE, Greenhouse gas, Cyprus, [SDE]Environmental Sciences, Mediterranean area, France
Abstract: In Europe, regions in the Mediterranean area share common characteristics in terms of high sensitivity to climate change impacts. Does this translate into specificities regarding climate action that could arise from these Mediterranean characteristics? This paper sheds light on regional and local climate mitigation actions of the Mediterranean Europe, focusing on the plans to reduce greenhouse gases emissions in a representative sample of 51 regions and 73 cities across 9 Mediterranean countries (Croatia, Cyprus, France, Greece, Italy, Malta, Portugal, Slovenia, Spain). The study investigates: (i) the availability of local and regional mitigation plans, (ii) their goals in term of greenhouse gas emissions reduction targets on the short and medium-long term, and (iii) the impact of transnational climate networks on such local and regional climate mitigation planning. Results of this study indicate an uneven and fragmented planning, that shows a Mediterranean West-East divide, and a link with population size. However, overall, both regional and city action seem insufficiently ambitious with regards to meeting the Paris Agreement, at least at city level. While national frameworks are currently weak in influencing regional and local actions, transnational networks seem to be engaging factors for commitment (at city level) and ambitiousness (at regional level). The uneven and fragmented progress revealed by this study, does not align with the characteristics shared by investigated regions and cities in terms of environmental, socio-political, climatic and economic conditions. The results support the call of a common green deal at the Mediterranean level to further address specific Mediterranean challenges and related needs. This will allow to capitalise on available resources, generate local-specific knowledge, build capacities, and support Mediterranean regions and cities in preparing the next generation of more ambitious mitigation plans. info:eu-repo/semantics/publishedVersion
Published: 2021
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49. Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data From a Systematic Review of Animal Studies

Author: Christos Kontogiorgis, Marika Massaro, Egeria Scoditti, E. Kistanova, Anna Arola-Arnal, Vladimir Ajdžanović, Evert M. van Schothorst, Eirini Deligiannidou, Dragan Milenkovic, Irena Krga, Banu Bayram, Karla Fabiola Corral-Jara, David Vauzour, Tatjana Ruskovska, Christine Morand, Desislava Abadjieva, Jaroslav Havlik, Laurent-Emmanuel Monfoulet, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), University Goce Delcev (UGD), University of East Anglia [Norwich] (UEA), European Cooperation in Science and Technology (COST) A1403, Norwich Medical School, University of East Anglia, Norwich, UK., Dragan Milenkovic, Georgia-Eirini Deligiannidou, Elena K Kistanova, Laurent-Emmanuel Monfoulet, Tatjana Ruskovska, Irena Krga, Dr David Vauzour, and Jaroslav Havlík
Subjects: Bioinformatics analysis, 030309 nutrition & dietetics, Large range, Biology, nutrigenomic, Bioinformatics, Mice, 03 medical and health sciences, Nutrigenomics, dietary intervention, Animals, Epigenetics, Beneficial effects, VLAG, 030304 developmental biology, 0303 health sciences, Computational Biology, Polyphenols, animal models, Diet, Rats, 3. Good health, Gene Expression Regulation, Cardiovascular Diseases, Human and Animal Physiology, WIAS, Fysiologie van Mens en Dier, Animal studies, flavanols, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Target organ, Food Science, Biotechnology, cardiometabolic health
Abstract: International audience; Scope: Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. Methods and Results: To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. Conclusion: This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.
Published: 2021
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50. Causal effects of lifetime smoking on breast and colorectal cancer risk:Mendelian randomization study

Author: Marc J. Gunter, Inger T. Gram, Elisabete Weiderpass, Hilary A. Tindle, Sun-Seog Kweon, Renée T. Fortner, Rudolf Kaaks, Sarah J Lewis, James Yarmolinsky, Stephen B. Gruber, Marije F. Bakker, Li Hsu, Yi Lin, Neil Murphy, Polly A. Newcomb, Konstantinos K. Tsilidis, Noralane M. Lindor, Rosario Tumino, Gianluca Severi, Hermann Brenner, Emmanouil Bouras, Jane C. Figueiredo, Niki Dimou, Richard M. Martin, Bethany Van Guelpen, María-José Sánchez-Pérez, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Cancerfonden Cancer Research Foundation in Northern Sweden Deutsche Krebshilfe Vetenskapsrådet, VR Australian Lions Childhood Cancer Research Foundation, ALCCRF Knut och Alice Wallenbergs Stiftelse State of Maryland Vetenskapsrådet, VR: VR 2017-00650 Centers for Disease Control and Prevention, CDC Institut National Du Cancer, INCa National Institutes of Health, NIH National Cancer Institute, NCI: P30 CA015704 Centre Hospitalier Universitaire de Nantes, CHU de Nantes Conseil Régional des Pays de la Loire Association Anne de Bretagne Genetique Centre Hospitalier Universitaire de Nantes, CHU de Nantes U.S. Public Health Service, USPHS: HHSN261201500005C U.S. Department of Health and Human Services, HHS National Institutes of Health, NIH National Cancer Institute, NCI National Institute on Aging, NIA: U01 AG18033 Institut National Du Cancer, INCa: P30 CA006973, U01 CA86308 American Institute for Cancer Research, AICR European Commission, EC National Institutes of Health, NIH: R01 CA189184, 2P30CA015704-40, R01 CA207371, U01 CA206110 Matthias Lackas-Stiftung Johns Hopkins University, JHU: HHSN268201200008I National Cancer Institute, NCI National Institutes of Health, NIH: R01 CA143247, R01 CA81488, U01 CA122839, U19 CA148107, U01 CA167551 National Institutes of Health, NIH National Institute of Environmental Health Sciences, NIEHS: T32 ES013678 National Cancer Institute, NCI U.S. Department of Health and Human Services, HHS: R01 CA197350, R01 CA81488, R01 CA201407, P01 CA196569, U19 CA148107, P30 CA014089 Österreichische Forschungsförderungsgesellschaft, FFG: 829675 Instituto de Salud Carlos III, ISCIII European Regional Development Fund, ERDF: PI14-613, PI09-1286 Xarxa de Bancs de Tumors de Catalunya, XBTC: PT13/0010/0013 Generalitat de Catalunya: 2017SGR723 Junta de Castilla y León: LE22A10-2 Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR Ministerstvo Zdravotnictví Ceské Republiky, MZCR: AZV 17-30920A, AZV 15-27580A Grantová Agentura České Republiky, GA ČR: CZ GA CR: GAP304/10/1286, 1585 Deutsche Forschungsgemeinschaft, DFG: HO 5117/2-1, BR 1704/6-1, KL 2354/3-1, BR 1704/6-4, BR 1704/6-3, CH 117/1-1, HE 5998/2-1, RO 2270/8-1, BR1704/17-1 Bundesministerium für Bildung und Forschung, BMBF: 01ER0814, 01KH0404, 01ER0815, 01ER1505A, 01ER1505B U01 CA 84968-06 National Cancer Institute, NCI University of Maryland School of Public Health, SPH NIHR Imperial Biomedical Research Centre, BRC Imperial College London NIHR Imperial Biomedical Research Centre, BRC Centre International de Recherche sur le Cancer, CIRC Ministerie van Volksgezondheid, Welzijn en Sport, VWS Deutsche Krebshilfe Cancer Research UK, CRUK: C8221/A29017 Ministerie van Volksgezondheid, Welzijn en Sport, VWS Vetenskapsrådet, VR Ligue Contre le Cancer Bundesministerium für Bildung und Forschung, BMBF Bundesministerium für Bildung und Forschung, BMBF Kræftens Bekæmpelse, DCS Associazione Italiana per la Ricerca sul Cancro, AIRC Instituto de Salud Carlos III, ISCIII Deutsches Krebsforschungszentrum, DKFZ Institut National de la Santé et de la Recherche Médicale, Inserm National Research Council, NRC Institut Gustave-Roussy Deutsches Krebsforschungszentrum, DKFZ Cancerfonden World Cancer Research Fund, WCRF Medical Research Council, MRC: MR/M012190/1 Generalitat de Catalunya: 2017SGR653, 2014SGR135, 2014SGR255, 2017SGR21 SAF2014-54453R, SAF07-64873, SAF 2010-19273 Xunta de Galicia: PGIDIT07PXIB9101209PR Instituto de Salud Carlos III, ISCIII European Regional Development Fund, ERDF: PS09/02368, PI14/00230, 17/00878, PI08/1276, PI17/00509, PI08/0024, PI11/00681, P111/00219, PI14/00173 Xarxa de Bancs de Tumors de Catalunya, XBTC: SLT002/ 16/00398 GCB13131592CAST European Cooperation in Science and Technology, COST: CA17118, BM1206 Deutsche Krebshilfe National Institutes of Health, NIH: K07 CA190673, P01 CA055075, K07CA190673, R35CA197735, U01 CA167552, UM1 CA167552, R01 CA042182, P01 CA087969, R01 CA151993, P50 CA127003, UM1 CA186107, R35 CA197735, R01 CA137178 HCRI15011-1 National Cancer Institute, NCI: R01CA136726 Damon Runyon Cancer Research Foundation, DRCRF: CI-8 Food Standards Agency, FSA Cancer Research UK, CRUK: C588/A19167 VicHealth Cancer Council Victoria National Health and Medical Research Council, NHMRC: 251553, 209057, 509348, 504711 National Institutes of Health, NIH U.S. Department of Health and Human Services, HHS: R01 CA81488 Florida Department of Health: 09BN-13 National Institutes of Health, NIH: R01 CA189184, P30 CA076292 National Institutes of Health, NIH: P30 DK034987, R01 CA66635 18226, 18223 Canadian Institutes of Health Research, CIHR: CRT 43821 National Institutes of Health, NIH U.S. Department of Health and Human Services, HHS: U01 CA74783 Cancerfonden Cancer Research Foundation, CRF Vetenskapsrådet, VR Australian Lions Childhood Cancer Research Foundation, ALCCRF Canadian Cancer Society National Institutes of Health, NIH: U01/ U24 CA074783, U01 CA167551 Pelotonia CA16058, CA67941 Canadian Institutes of Health Research, CIHR: 112746 Ontario Research Foundation, ORF: GL201-043 National Cancer Institute, NCI U.S. Department of Health and Human Services, HHS: U01 HG004446, GEI U01 HG 004438, Z01 CP 010200 Division of Cancer Epidemiology and Genetics, National Cancer Institute, DCEG Institut National Du Cancer, INCa National Institutes of Health, NIH Division of Cancer Prevention, National Cancer Institute, DCP, NCI National Institutes of Health, NIH: U24 CA074794, U01 CA074794, R01 CA076366, U01 CA167551 National Cancer Institute, NCI National Institutes of Health, NIH: UM1 CA182883, U10 CA37429 National Cancer Institute, NCI Institut National Du Cancer, INCa: R03 CA153323, P01 CA074184, K05 CA152715, R01 CA097325 National Institutes of Health, NIH: KL2 TR000421 National Center for Advancing Translational Sciences, NCATS Stockholms Läns Landsting Vetenskapsrådet, VR: K2015-55X-22674-01-4, K2008-55X-20157-03-3, K2006-72X-20157-01-2 Karolinska Institutet, KI National Institutes of Health, NIH: K05 CA154337 Swedish Cancer Foundation National Heart, Lung, and Blood Institute, NHLBI National Institutes of Health, NIH U.S. Department of Health and Human Services, HHS: HHSN268201100004C, HHSN268201100003C, HHSN268201100001C, HHSN271201100004C, HHSN268201100046C, HHSN268201100002C, R.M. Martin reports grants from Cancer Research UK during the conduct of the study. R.T. Fortner reports that grants from German Cancer Aid and from German Ministry of Education and Research supported the conduct of EPIC Heidelberg. S.B. Gruber reports other from Brogent International LLC outside the submitted work. B. van Guelpen reports grants from Swedish Research Council, Swedish Cancer Society, Knut and Alice Wallenberg Foundation, Lion’s Cancer Research Foundation at Umea° University, and Cancer Research Foundation in Northern Sweden during the conduct of the study. No disclosures were reported by the other authors., CLUE: We appreciate the continued efforts of the staff members at the Johns Hopkins George W. Comstock Center for Public Health Research and Prevention in the conduct of the CLUE II study. We thank the participants in CLUE. Cancer incidence data for CLUE were provided by the Maryland Cancer Registry, Center for Cancer Surveillance and Control, Maryland Department of Health, 201 W. Preston Street, Room 400, Baltimore, MD 21201, http://phpa.dhmh.maryland.gov/cancer, 410-767-4055. We acknowledge the State of Maryland, the Maryland Cigarette Restitution Fund, and the National Program of Cancer Registries of the Centers for Disease Control and Prevention for the funds that support the collection and availability of the cancer registry data., CPS-II: The authors thank the CPS-II participants and Study Management Group for their invaluable contributions to this research. The authors would also like to acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention National Program of Cancer Registries, and cancer registries supported by the National Cancer Institute Surveillance Epidemiology and End Results program., NSHDS investigators thank the Biobank Research Unit at Umea° University, the V€asterbotten Intervention Programme, the Northern Sweden MONICA study and Region V€asterbotten for providing data and samples and acknowledge the contribution from Biobank Sweden, supported by the Swedish Research Council (VR 2017-00650)., Cancer incidence data have been provided by the District of Columbia Cancer Registry, Georgia Cancer Registry, Hawaii Cancer Registry, Minnesota Cancer Surveillance System, Missouri Cancer Registry, Nevada Central Cancer Registry, Pennsylvania Cancer Registry, Texas Cancer Registry, Virginia Cancer Registry, and Wisconsin Cancer Reporting System. All are supported in part by funds from the Center for Disease Control and Prevention, National Program for Central Registries, local states or by the National Cancer Institute, Surveillance, Epidemiology, and End Results program. The results reported here and the conclusions derived are the sole responsibility of the authors., Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO): National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services (U01 CA137088, R01 CA059045, R01CA201407). This research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA015704., ASTERISK: a Hospital Clinical Research Program (PHRC-BRD09/C) from the University Hospital Center of Nantes (CHU de Nantes) and supported by the Regional Council of Pays de la Loire, the Groupement des EntreprisesFranc¸aises dans la Luttecontre le Cancer (GEFLUC), the Association Anne de Bretagne Génétique and the Ligue RégionaleContre le Cancer (LRCC)., The ATBC Study is supported by the Intramural Research Program of the U.S. National Cancer Institute, National Institutes of Health, and by U.S. Public Health Service contract HHSN261201500005C from the National Cancer Institute, Department of Health and Human Services., CLUE funding was from the National Cancer Institute (U01 CA86308, Early Detection Research Network, and P30 CA006973), National Institute on Aging (U01 AG18033), and the American Institute for Cancer Research. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government. COLO2&3: NIH (R01 CA60987).
Subjects: Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Epidemiology, medicine.drug_class, Colorectal cancer, Breast Neoplasms, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Risk Factors, Internal medicine, Mendelian randomization, Genetic predisposition, Humans, Medicine, Risk factor, 11 Medical and Health Sciences, business.industry, Smoking, Odds ratio, Mendelian Randomization Analysis, medicine.disease, Confidence interval, 3. Good health, Causality, 030104 developmental biology, Estrogen, 030220 oncology & carcinogenesis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ICEP, Colorectal Neoplasms, business, Genome-Wide Association Study
Abstract: Background: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and colorectal cancer. Methods: Genome-Wide Association Study summary data were used to identify genetic variants associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants). Using two-sample MR, we examined these variants in relation to incident breast (122,977 cases/105,974 controls) and colorectal cancer (52,775 cases/45,940 controls). Results: In inverse-variance weighted models, a genetic predisposition to higher lifetime amount of smoking was positively associated with breast cancer risk [OR per 1-SD increment: 1.13; 95% confidence interval (CI): 1.00–1.26; P = 0.04]; although heterogeneity was observed. Similar associations were found for estrogen receptor–positive and estrogen receptor–negative tumors. Higher lifetime amount of smoking was positively associated with colorectal cancer (OR per 1-SD increment, 1.21; 95% CI, 1.04–1.40; P = 0.01), colon cancer (OR, 1.31; 95% CI, 1.11–1.55; P < 0.01), and rectal cancer (OR, 1.36; 95% CI, 1.07–1.73; P = 0.01). Ever having smoked regularly was not associated with risks of breast (OR, 1.01; 95% CI, 0.90–1.14; P = 0.85) or colorectal cancer (OR, 0.97; 95% CI, 0.86–1.10; P = 0.68). Conclusions: These findings are consistent with prior observational evidence and support a causal role of higher lifetime smoking amount in the development of breast and colorectal cancer. Impact: The results from this comprehensive MR analysis indicate that lifetime smoking is a causal risk factor for these common malignancies.
Published: 2021
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