624 results on '"Ervin, J"'
Search Results
2. Trajectories of job insecurity and the probability of poorer mental health among prime working-age Australian women and men
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Ervin, J, LaMontagne, A, Taouk, Y, King, T, Ervin, J, LaMontagne, A, Taouk, Y, and King, T
- Abstract
Precarious and insecure employment arrangements are important social determinants of health. Prior evidence has consistently found perceived job insecurity to be associated with poorer mental health. Nonetheless, several key under-researched areas remain in the existing evidence base. This study addresses some of these gaps by examining trajectories of job (in)security and assessing the effect of various persistent job security trajectories on subsequent mental health of both men and women. Utilising 15 waves of data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey, we employed group-based trajectory modelling (GBTM) to identify trajectories of job (in)security through men and women's prime working years (from baseline age of 28-38yrs to 41-51yrs) across 14 years (waves 5-18), before subsequently examining the associations between these estimated trajectories and mental health at wave 19 (aged 42-52yrs). We identified four distinct trajectories of job (in)security for both men and women: persistently secure, becoming more secure, becoming less secure, and persistently insecure. Examining the association between these trajectories and mental health, we found that chronic exposure to any amount of persistent job insecurity (improving, worsening or persistently insecure) is detrimental to the mental health of both men and women. Furthermore, a somewhat incremental or dose dependant effect was found, with persistent job insecurity associated with the largest declines in mental health scores. Given mental health disorders are a substantial cause of disability globally, our study provides evidence that developing policy and practice interventions to reduce job insecurity (as an increasingly recognised and highly modifiable social determinant of mental health) has considerable potential to enact positive population health improvements.
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- 2024
3. Unpaid caregiving and mental health during the COVID-19 pandemic-A systematic review of the quantitative literature
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Frey, R, Ervin, J, Alfonzo, LF, Taouk, Y, Maheen, H, King, T, Frey, R, Ervin, J, Alfonzo, LF, Taouk, Y, Maheen, H, and King, T
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The COVID-19 pandemic imposed additional and specific challenges on the lives and wellbeing of informal unpaid carers. Addressing an important gap in the existing literature, this systematic review (prospectively registered with PROSPERO CRD42022376012) synthesises and evaluates the quantitative evidence examining the association between unpaid caregiving and mental health (compared to non-caring), during the pandemic. Five databases were searched (Medline, PsycInfo, EMBASE, Scopus, Web of Science) from Jan 1, 2020, to March 1, 2023. Population-based, peer-reviewed quantitative studies using any observational design were included, with screening, data extraction and quality assessment (amended NOS) independently conducted by two reviewers. Of the 3,073 records screened, 20 eligible studies (113,151 participants) were included. Overall quality of evidence was moderate. Narrative synthesis was complemented by Effect-direction and Albatross plots (given significant between-study heterogeneity precluded meta-analysis). Results indicate that the mental health of informal carers, already poorer pre-COVID compared to non-caregivers, was disproportionally impacted as a result of the pandemic and its associated public health containment measures. This review highlights the vulnerability of this group and should motivate political will and commensurate policies to ensure unpaid caregivers are better supported now, in the medium term, and crucially if, and when, another global public health emergency emerges.
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- 2024
4. Author Correction: Anthropogenic modification of forests means only 40% of remaining forests have high ecosystem integrity
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Grantham, H. S., Duncan, A., Evans, T. D., Jones, K. R., Beyer, H. L., Schuster, R., Walston, J., Ray, J. C., Robinson, J. G., Callow, M., Clements, T., Costa, H. M., DeGemmis, A., Elsen, P. R., Ervin, J., Franco, P., Goldman, E., Goetz, S., Hansen, A., Hofsvang, E., Jantz, P., Jupiter, S., Kang, A., Langhammer, P., Laurance, W. F., Lieberman, S., Linkie, M., Malhi, Y., Maxwell, S., Mendez, M., Mittermeier, R., Murray, N. J., Possingham, H., Radachowsky, J., Saatchi, S., Samper, C., Silverman, J., Shapiro, A., Strassburg, B., Stevens, T., Stokes, E., Taylor, R., Tear, T., Tizard, R., Venter, O., Visconti, P., Wang, S., and Watson, J. E. M.
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- 2021
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5. The Oxytocin Antagonist Cligosiban Fails to Prolong Intravaginal Ejaculatory Latency in Men with Lifelong Premature Ejaculation: Results of a Randomized, Double-Blind, Placebo-Controlled Phase IIb trial (PEDRIX)
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Jennings, W., Adams, M., Althof, S., Shockey, G., Kaminetsky, J., Miner, M., Belkoff, L., Gittelman, M., Goldstein, I., Reynolds, M., Severance, R., Kopp, J., Schumacher, D., White, C., Morgentaler, A., Rhee, M., Ellison, W., Francyk, D., Molin, C., Ervin, J., Efros, M., Altamirano, D., Noss, M., Croft, H., Miller, J., Church, P., Banov, M., Polepalle, S., Herman, C., Crocket, E., Rauzi, F., Althof, Stanley, Osterloh, Ian H., Muirhead, Gary J., George, Katie, and Girard, Nicolas
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- 2019
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6. Placental insufficiency and heavier placentas in sheep after suppressing CXCL12/CXCR4 signaling during implantation.
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Ashley, R L, primary, Trigo, E M, additional, and Ervin, J M, additional
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- 2023
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7. The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description
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Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J.-M., Deleuze, M., Rull, F., Manrique, J.-A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J.-P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J.-C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q.-M., Legett, IV, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J.-F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H.-C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., and Wong, K. W.
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- 2021
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8. Anthropogenic modification of forests means only 40% of remaining forests have high ecosystem integrity
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Grantham, H. S., Duncan, A., Evans, T. D., Jones, K. R., Beyer, H. L., Schuster, R., Walston, J., Ray, J. C., Robinson, J. G., Callow, M., Clements, T., Costa, H. M., DeGemmis, A., Elsen, P. R., Ervin, J., Franco, P., Goldman, E., Goetz, S., Hansen, A., Hofsvang, E., Jantz, P., Jupiter, S., Kang, A., Langhammer, P., Laurance, W. F., Lieberman, S., Linkie, M., Malhi, Y., Maxwell, S., Mendez, M., Mittermeier, R., Murray, N. J., Possingham, H., Radachowsky, J., Saatchi, S., Samper, C., Silverman, J., Shapiro, A., Strassburg, B., Stevens, T., Stokes, E., Taylor, R., Tear, T., Tizard, R., Venter, O., Visconti, P., Wang, S., and Watson, J. E. M.
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- 2020
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9. Observation of Strange Kinetics in Protein Folding
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Sabelko, J., Ervin, J., and Gruebele, M.
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- 1999
10. Un vaccin expérimental candidat à base de protéine F de préfusion du virus respiratoire syncytial (VRS) (RSVPreF3) est immunogène lorsqu'il est administré à des adultes âgés de plus de 60 ans: résultats 6 mois après la vaccination
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Gruber, A., primary, Schwarz, au nom des auteurs : T.F., additional, Hwang, S.J., additional, Ylisastigui, P.P, additional, Liu, C-S., additional, Takazawa, K., additional, Yono, M., additional, Ervin, J., additional, Andrews, C., additional, Fogarty, C., additional, Eckermann, T., additional, Collete, D., additional, de Heusch, M., additional, De Schrevel, N., additional, Salaun, B., additional, Lievens, M., additional, Maréchal, C., additional, Nakanwagi, P., additional, and Hulstrøm, V., additional
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- 2023
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11. A Candidate Respiratory Syncytial Virus (RSV) Prefusion F Protein Investigational Vaccine (RSVPreF3 OA) Is Immunogenic when Administered in Adults≥60 Years of Age: Results at 6 Months after Vaccination
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Schwarz, T, additional, Hwang, S, additional, Ylisastigui, P, additional, Liu, C, additional, Takazawa, K, additional, Yono, M, additional, Ervin, J, additional, Andrews, C, additional, Fogarty, C, additional, Eckermann, T, additional, Collete, D, additional, de Heusch, M, additional, de Schrevel, N, additional, Salaun, B, additional, Lievens, M, additional, Maréchal, C, additional, Nakanwagi, P, additional, and Hulstrøm, V, additional
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- 2023
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12. A systematic review comparing cardiovascular disease among informal carers and non-carers
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Lambrias, A, Ervin, J, Taouk, Y, King, T, Lambrias, A, Ervin, J, Taouk, Y, and King, T
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Exposure to chronic stress increases the risk of cardiovascular disease (CVD). Providing informal care is known to be a stressful activity, but it is not clear whether informal caregiving is associated with CVD risk. This systematic review aimed to summarise and assess the quantitative evidence examining the association between providing informal care to others and CVD incidence in comparison with non-carers. Eligible articles were detected by searching six electronic literature databases (CINAHL, Embase, Global Health, OVID Medline, Scopus, and Web of Science). Two reviewers appraised 1887 abstracts and 34 full-text articles against a set of a priori eligibility criteria to identify articles for inclusion. Quality assessment of included studies was performed using the ROBINS-E risk of bias tool. Nine studies were identified that quantitatively assessed the association between providing informal care and CVD incidence in comparison to not providing informal care. Overall, there was no difference in the incidence of CVD between carers and non-carers across these studies. However, within the subgroup of studies that examined care provision intensity (hours/week) higher CVD incidence was observed for the most intense caregiving group compared to non-carers. One study examined only CVD-related mortality outcomes, observing a reduction in mortality for carers compared to non-carers. More research is required to explore the relationship between informal care and CVD incidence.
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- 2023
13. Gender identity and sexual orientation: a glossary
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Ervin, J, Scovelle, A, Churchill, B, Maheen, H, King, T, Ervin, J, Scovelle, A, Churchill, B, Maheen, H, and King, T
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Gender and sexually diverse populations remain understudied and under-represented in research. This is attributable not only to significant and ongoing data collection limitations, where large population-based studies fail to ask adequate questions around gender and sexuality, but also due to continuously evolving terminology in this space. This glossary takes a preliminary step in rectifying these issues by defining and clarifying the application and understanding of key terms related to gender, gender identity, expression and sexuality. In doing so, this glossary provides a point of reference for understanding key differences in gender and sexually diverse terminology to (1) help guide researchers and practitioners in the use and understanding of terms and (2) facilitate the utility of more respectful, inclusive and consistent language application across the public health arena.
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- 2023
14. The Regional Monitoring Program for Water Quality in San Francisco Bay, California, USA: Science in support of managing water quality
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Trowbridge, P.R., Davis, J.A., Mumley, T., Taberski, K., Feger, N., Valiela, L., Ervin, J., Arsem, N., Olivieri, A., Carroll, P., Coleman, J., Salop, P., Sutton, R., Yee, D., McKee, L.J., Sedlak, M., Grosso, C., and Kelly, J.
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- 2016
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15. SEIS: Insight’s Seismic Experiment for Internal Structure of Mars
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Lognonné, P., Banerdt, W. B., Giardini, D., Pike, W. T., Christensen, U., Laudet, P., de Raucourt, S., Zweifel, P., Calcutt, S., Bierwirth, M., Hurst, K. J., Ijpelaan, F., Umland, J. W., Llorca-Cejudo, R., Larson, S. A., Garcia, R. F., Kedar, S., Knapmeyer-Endrun, B., Mimoun, D., Mocquet, A., Panning, M. P., Weber, R. C., Sylvestre-Baron, A., Pont, G., Verdier, N., Kerjean, L., Facto, L. J., Gharakanian, V., Feldman, J. E., Hoffman, T. L., Klein, D. B., Klein, K., Onufer, N. P., Paredes-Garcia, J., Petkov, M. P., Willis, J. R., Smrekar, S. E., Drilleau, M., Gabsi, T., Nebut, T., Robert, O., Tillier, S., Moreau, C., Parise, M., Aveni, G., Ben Charef, S., Bennour, Y., Camus, T., Dandonneau, P. A., Desfoux, C., Lecomte, B., Pot, O., Revuz, P., Mance, D., tenPierick, J., Bowles, N. E., Charalambous, C., Delahunty, A. K., Hurley, J., Irshad, R., Liu, Huafeng, Mukherjee, A. G., Standley, I. M., Stott, A. E., Temple, J., Warren, T., Eberhardt, M., Kramer, A., Kühne, W., Miettinen, E.-P., Monecke, M., Aicardi, C., André, M., Baroukh, J., Borrien, A., Bouisset, A., Boutte, P., Brethomé, K., Brysbaert, C., Carlier, T., Deleuze, M., Desmarres, J. M., Dilhan, D., Doucet, C., Faye, D., Faye-Refalo, N., Gonzalez, R., Imbert, C., Larigauderie, C., Locatelli, E., Luno, L., Meyer, J.-R., Mialhe, F., Mouret, J. M., Nonon, M., Pahn, Y., Paillet, A., Pasquier, P., Perez, G., Perez, R., Perrin, L., Pouilloux, B., Rosak, A., Savin de Larclause, I., Sicre, J., Sodki, M., Toulemont, N., Vella, B., Yana, C., Alibay, F., Avalos, O. M., Balzer, M. A., Bhandari, P., Blanco, E., Bone, B. D., Bousman, J. C., Bruneau, P., Calef, F. J., Calvet, R. J., D’Agostino, S. A., de los Santos, G., Deen, R. G., Denise, R. W., Ervin, J., Ferraro, N. W., Gengl, H. E., Grinblat, F., Hernandez, D., Hetzel, M., Johnson, M. E., Khachikyan, L., Lin, J. Y., Madzunkov, S. M., Marshall, S. L., Mikellides, I. G., Miller, E. A., Raff, W., Singer, J. E., Sunday, C. M., Villalvazo, J. F., Wallace, M. C., Banfield, D., Rodriguez-Manfredi, J. A., Russell, C. T., Trebi-Ollennu, A., Maki, J. N., Beucler, E., Böse, M., Bonjour, C., Berenguer, J. L., Ceylan, S., Clinton, J., Conejero, V., Daubar, I., Dehant, V., Delage, P., Euchner, F., Estève, I., Fayon, L., Ferraioli, L., Johnson, C. L., Gagnepain-Beyneix, J., Golombek, M., Khan, A., Kawamura, T., Kenda, B., Labrot, P., Murdoch, N., Pardo, C., Perrin, C., Pou, L., Sauron, A., Savoie, D., Stähler, S., Stutzmann, E., Teanby, N. A., Tromp, J., van Driel, M., Wieczorek, M., Widmer-Schnidrig, R., and Wookey, J.
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- 2019
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16. A new method for detection of distant supernova neutrino bursts
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Cline, David B, Foshe, Tyler, Fenyves, Ervin J, Fuller, George M, Meyer, Bradley S, and Wilson, James R
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We suggest a new method for detection of neutrino bursts generated by distant supernovas in our galaxy and in the local group of galaxies. This new method is based on the detection of neutrons produced in the inelastic scattering of νμ and ντ neutrinos with nuclei via the neutral current channel. The advantages of such a detector are (1) the enhancement of neutrino scattering cross sections due to nuclear collective effects, (2) the selective detection of νμ and ντ supernova neutrinos, and (3) the existence of large geological deposits of suitable neutrino detector materials in nature. © 1990.
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- 1990
17. Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis
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Zhou, Z, Jardine, M, Li, Q, Neuen, B, Cannon, C, De Zeeuw, D, Edwards, R, Levin, A, Mahaffey, K, Perkovic, V, Neal, B, Lindley, R, Guerrero, R, Aizenberg, D, Albisu, J, Alvarisqueta, A, Bartolacci, I, Berli, M, Bordonava, A, Calella, P, Cantero, M, Cartasegna, L, Cercos, E, Coloma, G, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, C, Cusumano, A, Douthat, W, Dran, R, Farias, E, Fernandez, M, Finkelstein, H, Fragale, G, Fretes, J, Garcia, N, Gastaldi, A, Gelersztein, E, Glenny, J, Gonzalez, J, Del Carmen Gonzalez Colaso, P, Goycoa, C, Greloni, G, Guinsburg, A, Hermida, S, Juncos, L, Klyver, M, Kraft, F, Krynski, F, Lanchiotti, P, De La Fuente, R, Marchetta, N, Mele, P, Nicolai, S, Novoa, P, Orio, S, Otreras, F, Oviedo, A, Raffaele, P, Resk, J, Rista, L, Papini, N, Sala, J, Santos, J, Schiavi, L, Sessa, H, Casabella, T, Ulla, M, Valdez, M, Vallejos, A, Villarino, A, Visco, V, Wassermann, A, Zaidman, C, Cheung, N, Droste, C, Fraser, I, Johnson, D, Mah, P, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, R, Da Costa, F, Amodeo, C, Turatti, L, Bregman, R, Sanches, F, Canani, L, Chacra, A, Borges, J, Vencio, S, Da Silva Franco, R, D'Avila, D, De Souza Portes, E, De Souza, P, Deboni, L, Filho, F, Neto, B, Gomes, M, Kohara, S, Keitel, E, Saraiva, J, Lisboa, H, De Carvalho Contieri, F, Milagres, R, Junior, R, De Brito, C, Hissa, M, Sabbag, A, Noronha, I, Panarotto, D, Filho, R, Pereira, M, Saporito, W, Scotton, A, Schuch, T, De Almeida, R, Ramos, C, Felicio, J, Thome, F, Hachmann, J, Yamada, S, Hayashida, C, Petry, T, Zanella, M, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A, Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Cherney, D, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dube, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mc-Mahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, N, Montenegro, M, Jorquera, J, Farina, M, Gajardo, V, Vejar, M, Chen, N, Chen, Q, Gan, S, Kong, Y, Li, D, Li, W, Li, X, Lin, H, Liu, J, Lu, W, Mao, H, Ren, Y, Song, W, Sun, J, Sun, L, Tu, P, Wang, G, Yang, J, Yin, A, Yu, X, Zhao, M, Zheng, H, Mendoza, J, Arcos, E, Avendano, J, Ruiz, J, Ortiz, L, Gonzalez, A, Triana, E, Higuera, J, Malaver, N, De Salazar, D, Rosero, R, Lozano, M, Cometa, L, Valenzuela, A, Alonso, R, Villegas, I, Yupanqui, H, Bartaskova, D, Barton, P, Belobradkova, J, Dohnalova, L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, J, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, P, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Orellana, R, Haase, F, Diaz, J, Roca, L, Arenales, J, Polo, J, Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Oomman, A, Raju, S, Dewan, D, Fernando, M, Gopalakrishnan, N, Gracious, N, Alva, H, Jain, D, Keshavamurthy, C, Khullar, D, Sahay, M, Peringat, J, Prasad, N, Rao, K, Reddy, S, Melemadathil, S, Sudhakar, B, Vyasam, R, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, De Nicola, L, Derosa, G, Carlo, A, Cianni, G, Frasca, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, F, Serviddio, G, Stella, A, Trevisan, R, Veronelli, A, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T, Kajiyama, S, Kashine, S, Kawada, T, Kodera, T, Kono, H, Koyama, K, Kumeda, Y, Miyauchi, S, Mizuyama, K, Niiya, T, Oishi, H, Ota, S, Sakakibara, T, Takai, M, Tomonaga, O, Tsujimoto, M, Wada, T, Wakasugi, M, Wakida, Y, Watanabe, T, Yamada, M, Yanagida, K, Yanase, T, Yumita, W, Gaupsiene, E, Kozloviene, D, Navickas, A, Urbanaviciene, E, Ghani, R, Kadir, K, Ali, N, Yusof, M, Gan, C, Ismail, M, Kong, W, Lam, S, Lee, L, Lim, S, Loh, C, Manocha, A, Ng, K, Ahmad, N, Ratnasingam, V, Shudim, S, Vengadasalam, P, Munoz, L, Salazar, M, Cruz, J, Soto, M, Ramos, J, Wong, A, Rotter, J, Escalante, T, Sosa, F, Lozano, F, Cervera, L, Baron, P, Ballesteros, C, Rangel, J, Jimenez, L, Santana, S, Flores, F, Molina, H, Ceballos, R, Del Campo Blanco, B, Franco, G, Loza, O, Rocha, C, Vera, G, Castellanos, R, Calcaneo, J, Rosano, M, Pattzi, H, Guzman, J, Joerg, I, Sanchez, S, Mijangos, J, Sanson, P, Tamayo Y Orozco, J, Chavez, E, Cepeda, A, Carrillo, L, Mesa, J, Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, 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Y., Lim S. K., Loh C. L., Manocha A. B., Ng K. S., Ahmad N. N. F. N., Ratnasingam V., Shudim S. S. B., Vengadasalam P., Munoz L. D. A., Salazar M. A., Cruz J. B., Soto M. B., Ramos J. C., Wong A. C., Rotter J. R. C., Escalante T. D., Sosa F. E. E., Lozano F. F., Cervera L. F. F., Baron P. F., Ballesteros C. G., Rangel J. D. G., Jimenez L. E. H., Santana S. S. I., Flores F. J., Molina H. L., Ceballos R. I. L., Del Campo Blanco B. M., Franco G. M., Loza O. T. M., Rocha C. M., Vera G. O., Castellanos R. O., Calcaneo J. P., Rosano M. A. R., Pattzi H. R., Guzman J. R., Joerg I. E. R., Sanchez S. B. S., Mijangos J. H. S., Sanson P. S., Tamayo Y Orozco J. A., Chavez E. T., Cepeda A. V., Carrillo L. V., Mesa J. V., Escobedo R. Z., Baker J., Noonan P., Scott R., Walker R., Watson E., Williams M., Young S., Abejuela Z., Agra J., Aquitania G., Caringal C., Comia R. S., Santos L. D., Gomez O., Jimeno C., Santos F., Tan G., Tolentino M., Yao C., Yap Y. E., Ygpuara M. D. L., Bijata-Bronisz R., Hotlos L., Januszewicz A., Kaczmarek B., Kaminska A., Lazuka L., Madej A., Mazur S., Mlodawska-Choluj D., Nowicki M., Orlowska-Kowalik G., Popenda G., Rewerska B., Sowinski D., Angelescu L. M., Anghel V., Avram R. -I., Busegeanu M. -M., Cif A., Cosma D., Crisan C., Demian L. D., Ferariu I. E., Halmagyi I., Hancu N., Munteanu M., Negru D., Onaca A. G., Petrica L., Popa A. R., Ranetti A. -E., Serafinceanu C., Toarba C., Agafyina A., Barbarash O., Barysheva O., Chizhov D., Dobronravov V., Dreval A., Glinkina I., Grineva E., Khirmanov V., Kolmakova E., Koroleva T., Kvitkova L., Marasaev V., Mkrtumyan A., Morugova T., Nagibovich G., Nagibovich O., Nedogoda S., Osipova I., Raskina T., Samoylova Y., Sazonova O., Shamkhalova M., Shutemova E., Shwartz Y., Uriasyev O., Vorobyev S., Zateyshchikova A., Zateyshshikov D., Zykova T., Antic S., Djordjevic M., Kendereski A., Lalic K., Lalic N., Popovic-Radinovic V., Babikova J., Benusova O., Buganova I., Culak J., Dzupina A., Dzuponova J., Fulop P., Ilavska A., Martinka E., Ochodnicka Z., Pella D., Smatanova I., Ahmed F., Badat A., Breedt J., Distiller L., Govender V., Govender R., Joshi M., Jurgens J., Latiff G., Lombard L., Mookadam M., Ngcakani N., Nortje H., Oosthuizen H., Pillay-Ramaya L., Prozesky H., Reddy J., Rheeder P., Seeber M., Chae D. -W., Cho Y. M., Jeong I. -K., Kim S. G., Kim Y. H., Kwon H. -S., Kwon M. J., Lee B. -W., Lee J., Lee M. -K., Nam M. -S., Oh K. -H., Park C. -Y., Park S. -H., Yoon K. H., Garcia P. A., Mercadal L. A., Barrios C., Castro F. C., Guldris S. C., Lopez M. D., De Los Rios J. E., Fresnedo G. F., Serrano A. G., Garcia I., Martinez F. J. G., Gimeno J. E. J., Mendoza M. L., Marin T. M., Portillo C. M., Vila M. A. M., Torres M. M., Iglesias J. N., Perez J. P., Vera M. P., Perez J. M. P., Simon M. A. Q., Canonge R. S., Gonzalez A. S., Riera M. T., Madueno F. J. T., Plaza M. V., Chang C. -T., Chuang L. -M., Hsia T. -L., Hsieh C. -H., Hwang S. -J., Lin C. -C., Lu Y. -C., Sheu W. H. -H., Barna O., Bilyk S. D., Botsyurko V., Dudar I., Fushtey I., Godlevska O., Golovchenko O., Gyrina O., Kazmirchuk A., Kolesnyk M., Komisarenko I., Korzh O., Kravchun N., Legun O., Mankovskyy B., Martynyuk L., Mostovoy Y., Pashkovska N., Pererva L., Pertseva T., Samoylov O., Smirnov I., Svyshchenko Y., Tomashkevych H., Topchii I., Tryshchuk N., Tseluyko V., Vizir V., Vlasenko M., Zlova T., Zub L., Abusnana S., Railey M., Abouglila K., Ainsworth P., Ali Z., Arutchelvam V., Barnard M., Bellary S., Davies E., Davies M., Davies S., Dawson A., Kossi M. E., English P., Fraser D., Gnudi L., Gunstone A., Hall T., Hanif W., Jackson A., Johnson A., Joseph F., Krishnan S., Kumwenda M., MacDougall I., Nixon P., O'Hare J., Philip S., Ramtoola S., Saxena M., Sennik D., Simon G., Singh B., Stephens J., Strzelecka A., Symonds R., Turner W., Wahba M., Wakeling J., Wheeler D., Winocour P., Abdallah J., Abdullah R., Abramowitz M., Acosta I., Aiello J., Akright L., Akyea-Djamson A., Alappan R., Alicic R., Al-Karadsheh A., Allison D. C., Arauz-Pacheco C., Arfeen S., Arif A., Arvind M., Atray N., Awad A., Bakris G., Barnhill P., Barranco E., Barrera C., Beacom M., Behara V., Belo D., Bentley-Lewis R., Berenguer R., Bermudez L., Bernardo M., Biscoveanu M., Bowman-Stroud C., Brandon D., Brusco O., Busch R., Canaan Y., Chilito A., Christensen T., Christiano C., Christofides E., Chuateco C., Cohen K., Cohen R., Cohen-Stein D., Cook C., Coyne D., Daboul N., Darwish R., Daswani A., Deck K., Desouza C., Dev D., Dhillon M., Dua S., Eder F., Elosegui A. M., El-Shahawy M., Ervin J., Esquenazi A., Evans J., Fishbane S., Frias J., Galindo-Ramos E., Galphin C., Ghazi A., Gonzalez E., Gorson D., Gowda A., Greco B., Grubb S., Gulati R., Hammoud J., Handelsman S., Hartman I., Hershon K., Hiser D., Hon G., Jacob R., Jaime M., Jamal A., Kaupke C., Keightley G., Kern E., Khanna R., Khitan Z., Kim S., Kopyt N., Kovesdy C., Krishna G., Kropp J., Kumar A., Kumar J., Kumar N., Kusnir J., Lane W., Lawrence M., Lehrner L., Lentz J., Levinson D., Lewis D., Liss K., Maddux A., Maheshwari H., Mandayam S., Marar I., Mehta B., Middleton J., Mordujovich J., Moreda R., Moustafa M., Trenche S. M., Narayanan M., Narvarte J., Nassar T., Newman G., Nichol B., Nicol P., Nisnisan J., Nossuli A. K., Obialo C., Olelewe S., Oliver M., O'Shaughnessy A., Padron J., Pankhaniya R., Parker R., Patel D., Patel G., Patel N., Pavon H., Perez A., Perez C., Perlman A., Pettis K., Pharr W., Phillips A., Purighalla R., Quesada-Suarez L., Ranjan R., Rastogi S., Rendell M., Rich L., Robinson M., Rodriguez H., Rosas S., Saba F., Sankaram R., Sarin R., Schreiman R., Scott D., Sekkarie M., Sensenbrenner J., Shakeel M., Shanik M., Shaw S., Smith S., Solomon R., Sprague A., Spry L., Suchinda P., Sultan S., Surampudi P., Sussman S., Tan A., Terrelonge A., Thompson M., Trespalacios F., Trippe B., Trueba P., Twahirwa M., Updegrove J., Van Buren P., Vannorsdall M., Varghese F., Velasquez-Mieyer P., Ventrapragada S., Vukotic G., Wadud K., Warren M., Watson H., Watts R., Weiner D., Welker J., Welsh J., Williams S., and Zaniewski-Singh M.
- Abstract
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect
- Published
- 2021
18. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis
- Author
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Zhou Z., Jardine M. J., Li Q., Neuen B. L., Cannon C. P., De Zeeuw D., Edwards R., Levin A., Mahaffey K. W., Perkovic V., Neal B., Lindley R. I., Guerrero R. A. A., Aizenberg D., Albisu J. P., Alvarisqueta A., Bartolacci I., Berli M. A., Bordonava A., Calella P., Cantero M. C., Cartasegna L. R., Cercos E., Coloma G. C., Colombo H., Commendatore V., Cuadrado J., Cuneo C. A., Cusumano A. M., Douthat W. G., Dran R. D., Farias E., Fernandez M. F., Finkelstein H., Fragale G., Fretes J. O., Garcia N. H., Gastaldi A., Gelersztein E., Glenny J. A., Gonzalez J. P., Del Carmen Gonzalez Colaso P., Goycoa C., Greloni G. C., Guinsburg A., Hermida S., Juncos L. I., Klyver M. I., Kraft F., Krynski F., Lanchiotti P. V., De La Fuente R. A. L., Marchetta N., Mele P., Nicolai S., Novoa P. A., Orio S. I., Otreras F., Oviedo A., Raffaele P., Resk J. H., Rista L., Papini N. R., Sala J., Santos J. C., Schiavi L. B., Sessa H., Casabella T. S., Ulla M. R., Valdez M., Vallejos A., Villarino A., Visco V. E., Wassermann A., Zaidman C. J., Cheung N. W., Droste C., Fraser I., Johnson D., Mah P. M., Nicholls K., Packham D., Proietto J., Roberts A., Roger S., Tsang V., Raduan R. A., Da Costa F. A. A., Amodeo C., Turatti L. A. A., Bregman R., Sanches F. C. C., Canani L. H., Chacra A. R., Borges J. L. C., Vencio S. A. C., Da Silva Franco R. J., D'Avila D., De Souza Portes E., De Souza P., Deboni L. M., Filho F. F., Neto B. G., Gomes M., Kohara S. K., Keitel E., Saraiva J. F. K., Lisboa H. R. K., De Carvalho Contieri F. L., Milagres R., Junior R. M., De Brito C. M., Hissa M. N., Sabbag A. R. N., Noronha I., Panarotto D., Filho R. P., Pereira M. A., Saporito W., Scotton A. S., Schuch T., De Almeida R. S., Ramos C. S., Felicio J. S., Thome F., Hachmann J. C. T., Yamada S., Hayashida C. Y., Petry T. B. Z., Zanella M. T., Andreeva V., Angelova A., Dimitrov S., Genadieva V., Genova-Hristova G., Hristozov K., Kamenov Z., Koundurdjiev A., Lozanov L., Margaritov V., Nonchev B., Rangelov R., Shinkov A., Temelkova M., Velichkova E., Yakov A., Aggarwal N., Aronson R., Bajaj H., Cherney D., Chouinard G., Conway J., Cournoyer S., DaRoza G., De Serres S., Dube F., Goldenberg R., Gupta A., Gupta M., Henein S., Khandwala H., Leiter L., Madore F., Mc-Mahon A., Muirhead N., Pichette V., Rabasa-Lhoret R., Steele A., Tangri N., Torshizi A., Woo V., Zalunardo N., Montenegro M. A. F., Jorquera J. G. G., Farina M. M., Gajardo V. S., Vejar M., Chen N., Chen Q., Gan S., Kong Y., Li D., Li W., Li X., Lin H., Liu J., Lu W., Mao H., Ren Y., Song W., Sun J., Sun L., Tu P., Wang G., Yang J., Yin A., Yu X., Zhao M., Zheng H., Mendoza J. L. A., Arcos E., Avendano J., Ruiz J. E. A. D., Ortiz L. H. G., Gonzalez A., Triana E. H., Higuera J. D., Malaver N., De Salazar D. I. M., Rosero R., Lozano M. A. T., Cometa L. V., Valenzuela A., Alonso R. D. V., Villegas I., Yupanqui H., Bartaskova D., Barton P., Belobradkova J., Dohnalova L., Drasnar T., Ferkl R., Halciakova K., Klokocnikova V., Kovar R., Lastuvka J., Lukac M., Pesickova S., Peterka K., Pumprla J., Rychlik I., Saudek F., Tesar V., Valis M., Weiner P., Zemek S., Alamartine E., Borot S., Cariou B., Dussol B., Fauvel J. -P., Gourdy P., Klein A., Le Meur Y., Penfornis A., Roussel R., Saulnier P. -J., Thervet E., Zaoui P., Burst V., Faghih M., Faulmann G., Haller H., Jerwan-Keim R., Maxeiner S., Paschen B., Plassmann G., Rose L., Orellana R. A. G., Haase F. P., Diaz J. P. M., Roca L. A. R., Arenales J. A. S., Polo J. V. S., Juarez E. T., Csecsei G., Csiky B., Danos P., Deak L., Dudas M., Harcsa E., Keltai K., Keresztesi S., Kiss K., Konyves L., Major L., Mileder M., Molnar M., Mucsi J., Oroszlan T., Ory I., Paragh G., Peterfai E., Petro G., Revesz K., Takacs R., Vangel S., Vasas S., Zsom M., Oomman A., Raju S. B., Dewan D., Fernando M. E., Gopalakrishnan N., Gracious N., Alva H., Jain D., Keshavamurthy C. B., Khullar D., Sahay M., Peringat J., Prasad N., Rao K. S., Reddy S., Melemadathil S., Sudhakar B., Vyasam R. C., Bonadonna R., Castellino P., Ceriello A., Chiovato L., De Cosmo S., De Nicola L., Derosa G., Carlo A. D., Cianni G. D., Frasca G., Fuiano G., Gambaro G., Garibotto G., Giorda C., Malberti F., Mandreoli M., Mannucci E., Orsi E., Piatti P., Santoro D., Sasso F. C., Serviddio G., Stella A., Trevisan R., Veronelli A. M., Zanoli L., Akiyama H., Aoki H., Asano A., Iitsuka T., Kajiyama S., Kashine S., Kawada T., Kodera T., Kono H., Koyama K., Kumeda Y., Miyauchi S., Mizuyama K., Niiya T., Oishi H., Ota S., Sakakibara T., Takai M., Tomonaga O., Tsujimoto M., Wada T., Wakasugi M., Wakida Y., Watanabe T., Yamada M., Yanagida K., Yanase T., Yumita W., Gaupsiene E., Kozloviene D., Navickas A., Urbanaviciene E., Ghani R. A., Kadir K. A., Ali N., Yusof M. D. C., Gan C. L., Ismail M., Kong W. Y., Lam S. W., Lee L. Y., Lim S. K., Loh C. L., Manocha A. B., Ng K. S., Ahmad N. N. F. N., Ratnasingam V., Shudim S. S. B., Vengadasalam P., Munoz L. D. A., Salazar M. A., Cruz J. B., Soto M. B., Ramos J. C., Wong A. C., Rotter J. R. C., Escalante T. D., Sosa F. E. E., Lozano F. F., Cervera L. F. F., Baron P. F., Ballesteros C. G., Rangel J. D. G., Jimenez L. E. H., Santana S. S. I., Flores F. J., Molina H. L., Ceballos R. I. L., Del Campo Blanco B. M., Franco G. M., Loza O. T. M., Rocha C. M., Vera G. O., Castellanos R. O., Calcaneo J. P., Rosano M. A. R., Pattzi H. R., Guzman J. R., Joerg I. E. R., Sanchez S. B. S., Mijangos J. H. S., Sanson P. S., Tamayo Y Orozco J. A., Chavez E. T., Cepeda A. V., Carrillo L. V., Mesa J. V., Escobedo R. Z., Baker J., Noonan P., Scott R., Walker R., Watson E., Williams M., Young S., Abejuela Z., Agra J., Aquitania G., Caringal C., Comia R. S., Santos L. D., Gomez O., Jimeno C., Santos F., Tan G., Tolentino M., Yao C., Yap Y. E., Ygpuara M. D. L., Bijata-Bronisz R., Hotlos L., Januszewicz A., Kaczmarek B., Kaminska A., Lazuka L., Madej A., Mazur S., Mlodawska-Choluj D., Nowicki M., Orlowska-Kowalik G., Popenda G., Rewerska B., Sowinski D., Angelescu L. M., Anghel V., Avram R. -I., Busegeanu M. -M., Cif A., Cosma D., Crisan C., Demian L. D., Ferariu I. E., Halmagyi I., Hancu N., Munteanu M., Negru D., Onaca A. G., Petrica L., Popa A. R., Ranetti A. -E., Serafinceanu C., Toarba C., Agafyina A., Barbarash O., Barysheva O., Chizhov D., Dobronravov V., Dreval A., Glinkina I., Grineva E., Khirmanov V., Kolmakova E., Koroleva T., Kvitkova L., Marasaev V., Mkrtumyan A., Morugova T., Nagibovich G., Nagibovich O., Nedogoda S., Osipova I., Raskina T., Samoylova Y., Sazonova O., Shamkhalova M., Shutemova E., Shwartz Y., Uriasyev O., Vorobyev S., Zateyshchikova A., Zateyshshikov D., Zykova T., Antic S., Djordjevic M., Kendereski A., Lalic K., Lalic N., Popovic-Radinovic V., Babikova J., Benusova O., Buganova I., Culak J., Dzupina A., Dzuponova J., Fulop P., Ilavska A., Martinka E., Ochodnicka Z., Pella D., Smatanova I., Ahmed F., Badat A., Breedt J., Distiller L., Govender V., Govender R., Joshi M., Jurgens J., Latiff G., Lombard L., Mookadam M., Ngcakani N., Nortje H., Oosthuizen H., Pillay-Ramaya L., Prozesky H., Reddy J., Rheeder P., Seeber M., Chae D. -W., Cho Y. M., Jeong I. -K., Kim S. G., Kim Y. H., Kwon H. -S., Kwon M. J., Lee B. -W., Lee J., Lee M. -K., Nam M. -S., Oh K. -H., Park C. -Y., Park S. -H., Yoon K. H., Garcia P. A., Mercadal L. A., Barrios C., Castro F. C., Guldris S. C., Lopez M. D., De Los Rios J. E., Fresnedo G. F., Serrano A. G., Garcia I., Martinez F. J. G., Gimeno J. E. J., Mendoza M. L., Marin T. M., Portillo C. M., Vila M. A. M., Torres M. M., Iglesias J. N., Perez J. P., Vera M. P., Perez J. M. P., Simon M. A. Q., Canonge R. S., Gonzalez A. S., Riera M. T., Madueno F. J. T., Plaza M. V., Chang C. -T., Chuang L. -M., Hsia T. -L., Hsieh C. -H., Hwang S. -J., Lin C. -C., Lu Y. -C., Sheu W. H. -H., Barna O., Bilyk S. D., Botsyurko V., Dudar I., Fushtey I., Godlevska O., Golovchenko O., Gyrina O., Kazmirchuk A., Kolesnyk M., Komisarenko I., Korzh O., Kravchun N., Legun O., Mankovskyy B., Martynyuk L., Mostovoy Y., Pashkovska N., Pererva L., Pertseva T., Samoylov O., Smirnov I., Svyshchenko Y., Tomashkevych H., Topchii I., Tryshchuk N., Tseluyko V., Vizir V., Vlasenko M., Zlova T., Zub L., Abusnana S., Railey M., Abouglila K., Ainsworth P., Ali Z., Arutchelvam V., Barnard M., Bellary S., Davies E., Davies M., Davies S., Dawson A., Kossi M. E., English P., Fraser D., Gnudi L., Gunstone A., Hall T., Hanif W., Jackson A., Johnson A., Joseph F., Krishnan S., Kumwenda M., MacDougall I., Nixon P., O'Hare J., Philip S., Ramtoola S., Saxena M., Sennik D., Simon G., Singh B., Stephens J., Strzelecka A., Symonds R., Turner W., Wahba M., Wakeling J., Wheeler D., Winocour P., Abdallah J., Abdullah R., Abramowitz M., Acosta I., Aiello J., Akright L., Akyea-Djamson A., Alappan R., Alicic R., Al-Karadsheh A., Allison D. C., Arauz-Pacheco C., Arfeen S., Arif A., Arvind M., Atray N., Awad A., Bakris G., Barnhill P., Barranco E., Barrera C., Beacom M., Behara V., Belo D., Bentley-Lewis R., Berenguer R., Bermudez L., Bernardo M., Biscoveanu M., Bowman-Stroud C., Brandon D., Brusco O., Busch R., Canaan Y., Chilito A., Christensen T., Christiano C., Christofides E., Chuateco C., Cohen K., Cohen R., Cohen-Stein D., Cook C., Coyne D., Daboul N., Darwish R., Daswani A., Deck K., Desouza C., Dev D., Dhillon M., Dua S., Eder F., Elosegui A. M., El-Shahawy M., Ervin J., Esquenazi A., Evans J., Fishbane S., Frias J., Galindo-Ramos E., Galphin C., Ghazi A., Gonzalez E., Gorson D., Gowda A., Greco B., Grubb S., Gulati R., Hammoud J., Handelsman S., Hartman I., Hershon K., Hiser D., Hon G., Jacob R., Jaime M., Jamal A., Kaupke C., Keightley G., Kern E., Khanna R., Khitan Z., Kim S., Kopyt N., Kovesdy C., Krishna G., Kropp J., Kumar A., Kumar J., Kumar N., Kusnir J., Lane W., Lawrence M., Lehrner L., Lentz J., Levinson D., Lewis D., Liss K., Maddux A., Maheshwari H., Mandayam S., Marar I., Mehta B., Middleton J., Mordujovich J., Moreda R., Moustafa M., Trenche S. M., Narayanan M., Narvarte J., Nassar T., Newman G., Nichol B., Nicol P., Nisnisan J., Nossuli A. K., Obialo C., Olelewe S., Oliver M., O'Shaughnessy A., Padron J., Pankhaniya R., Parker R., Patel D., Patel G., Patel N., Pavon H., Perez A., Perez C., Perlman A., Pettis K., Pharr W., Phillips A., Purighalla R., Quesada-Suarez L., Ranjan R., Rastogi S., Rendell M., Rich L., Robinson M., Rodriguez H., Rosas S., Saba F., Sankaram R., Sarin R., Schreiman R., Scott D., Sekkarie M., Sensenbrenner J., Shakeel M., Shanik M., Shaw S., Smith S., Solomon R., Sprague A., Spry L., Suchinda P., Sultan S., Surampudi P., Sussman S., Tan A., Terrelonge A., Thompson M., Trespalacios F., Trippe B., Trueba P., Twahirwa M., Updegrove J., Van Buren P., Vannorsdall M., Varghese F., Velasquez-Mieyer P., Ventrapragada S., Vukotic G., Wadud K., Warren M., Watson H., Watts R., Weiner D., Welker J., Welsh J., Williams S., Zaniewski-Singh M., Zhou, Z., Jardine, M. J., Li, Q., Neuen, B. L., Cannon, C. P., De Zeeuw, D., Edwards, R., Levin, A., Mahaffey, K. W., Perkovic, V., Neal, B., Lindley, R. I., Guerrero, R. A. A., Aizenberg, D., Albisu, J. P., Alvarisqueta, A., Bartolacci, I., Berli, M. A., Bordonava, A., Calella, P., Cantero, M. C., Cartasegna, L. R., Cercos, E., Coloma, G. C., Colombo, H., Commendatore, V., Cuadrado, J., Cuneo, C. A., Cusumano, A. M., Douthat, W. G., Dran, R. D., Farias, E., Fernandez, M. F., Finkelstein, H., Fragale, G., Fretes, J. O., Garcia, N. H., Gastaldi, A., Gelersztein, E., Glenny, J. A., Gonzalez, J. P., Del Carmen Gonzalez Colaso, P., Goycoa, C., Greloni, G. C., Guinsburg, A., Hermida, S., Juncos, L. I., Klyver, M. I., Kraft, F., Krynski, F., Lanchiotti, P. V., De La Fuente, R. A. L., Marchetta, N., Mele, P., Nicolai, S., Novoa, P. A., Orio, S. I., Otreras, F., Oviedo, A., Raffaele, P., Resk, J. H., Rista, L., Papini, N. R., Sala, J., Santos, J. C., Schiavi, L. B., Sessa, H., Casabella, T. S., Ulla, M. R., Valdez, M., Vallejos, A., Villarino, A., Visco, V. E., Wassermann, A., Zaidman, C. J., Cheung, N. W., Droste, C., Fraser, I., Johnson, D., Mah, P. 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T., Csecsei, G., Csiky, B., Danos, P., Deak, L., Dudas, M., Harcsa, E., Keltai, K., Keresztesi, S., Kiss, K., Konyves, L., Major, L., Mileder, M., Molnar, M., Mucsi, J., Oroszlan, T., Ory, I., Paragh, G., Peterfai, E., Petro, G., Revesz, K., Takacs, R., Vangel, S., Vasas, S., Zsom, M., Oomman, A., Raju, S. B., Dewan, D., Fernando, M. E., Gopalakrishnan, N., Gracious, N., Alva, H., Jain, D., Keshavamurthy, C. B., Khullar, D., Sahay, M., Peringat, J., Prasad, N., Rao, K. S., Reddy, S., Melemadathil, S., Sudhakar, B., Vyasam, R. C., Bonadonna, R., Castellino, P., Ceriello, A., Chiovato, L., De Cosmo, S., De Nicola, L., Derosa, G., Carlo, A. D., Cianni, G. D., Frasca, G., Fuiano, G., Gambaro, G., Garibotto, G., Giorda, C., Malberti, F., Mandreoli, M., Mannucci, E., Orsi, E., Piatti, P., Santoro, D., Sasso, F. C., Serviddio, G., Stella, A., Trevisan, R., Veronelli, A. 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M., Franco, G. M., Loza, O. T. M., Rocha, C. M., Vera, G. O., Castellanos, R. O., Calcaneo, J. P., Rosano, M. A. R., Pattzi, H. R., Guzman, J. R., Joerg, I. E. R., Sanchez, S. B. S., Mijangos, J. H. S., Sanson, P. S., Tamayo Y Orozco, J. A., Chavez, E. T., Cepeda, A. V., Carrillo, L. V., Mesa, J. V., Escobedo, R. Z., Baker, J., Noonan, P., Scott, R., Walker, R., Watson, E., Williams, M., Young, S., Abejuela, Z., Agra, J., Aquitania, G., Caringal, C., Comia, R. S., Santos, L. D., Gomez, O., Jimeno, C., Santos, F., Tan, G., Tolentino, M., Yao, C., Yap, Y. E., Ygpuara, M. D. L., Bijata-Bronisz, R., Hotlos, L., Januszewicz, A., Kaczmarek, B., Kaminska, A., Lazuka, L., Madej, A., Mazur, S., Mlodawska-Choluj, D., Nowicki, M., Orlowska-Kowalik, G., Popenda, G., Rewerska, B., Sowinski, D., Angelescu, L. M., Anghel, V., Avram, R. -I., Busegeanu, M. -M., Cif, A., Cosma, D., Crisan, C., Demian, L. D., Ferariu, I. E., Halmagyi, I., Hancu, N., Munteanu, M., Negru, D., Onaca, A. 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R., Ranetti, A. -E., Serafinceanu, C., Toarba, C., Agafyina, A., Barbarash, O., Barysheva, O., Chizhov, D., Dobronravov, V., Dreval, A., Glinkina, I., Grineva, E., Khirmanov, V., Kolmakova, E., Koroleva, T., Kvitkova, L., Marasaev, V., Mkrtumyan, A., Morugova, T., Nagibovich, G., Nagibovich, O., Nedogoda, S., Osipova, I., Raskina, T., Samoylova, Y., Sazonova, O., Shamkhalova, M., Shutemova, E., Shwartz, Y., Uriasyev, O., Vorobyev, S., Zateyshchikova, A., Zateyshshikov, D., Zykova, T., Antic, S., Djordjevic, M., Kendereski, A., Lalic, K., Lalic, N., Popovic-Radinovic, V., Babikova, J., Benusova, O., Buganova, I., Culak, J., Dzupina, A., Dzuponova, J., Fulop, P., Ilavska, A., Martinka, E., Ochodnicka, Z., Pella, D., Smatanova, I., Ahmed, F., Badat, A., Breedt, J., Distiller, L., Govender, V., Govender, R., Joshi, M., Jurgens, J., Latiff, G., Lombard, L., Mookadam, M., Ngcakani, N., Nortje, H., Oosthuizen, H., Pillay-Ramaya, L., Prozesky, H., Reddy, J., Rheeder, P., Seeber, M., Chae, D. -W., Cho, Y. M., Jeong, I. -K., Kim, S. G., Kim, Y. H., Kwon, H. -S., Kwon, M. J., Lee, B. -W., Lee, J., Lee, M. -K., Nam, M. -S., Oh, K. -H., Park, C. -Y., Park, S. -H., Yoon, K. H., Garcia, P. A., Mercadal, L. A., Barrios, C., Castro, F. C., Guldris, S. C., Lopez, M. D., De Los Rios, J. E., Fresnedo, G. F., Serrano, A. G., Garcia, I., Martinez, F. J. G., Gimeno, J. E. J., Mendoza, M. L., Marin, T. M., Portillo, C. M., Vila, M. A. M., Torres, M. M., Iglesias, J. N., Perez, J. P., Vera, M. P., Perez, J. M. P., Simon, M. A. Q., Canonge, R. S., Gonzalez, A. S., Riera, M. T., Madueno, F. J. T., Plaza, M. V., Chang, C. -T., Chuang, L. -M., Hsia, T. -L., Hsieh, C. -H., Hwang, S. -J., Lin, C. -C., Lu, Y. -C., Sheu, W. H. -H., Barna, O., Bilyk, S. D., Botsyurko, V., Dudar, I., Fushtey, I., Godlevska, O., Golovchenko, O., Gyrina, O., Kazmirchuk, A., Kolesnyk, M., Komisarenko, I., Korzh, O., Kravchun, N., Legun, O., Mankovskyy, B., Martynyuk, L., Mostovoy, Y., Pashkovska, N., Pererva, L., Pertseva, T., Samoylov, O., Smirnov, I., Svyshchenko, Y., Tomashkevych, H., Topchii, I., Tryshchuk, N., Tseluyko, V., Vizir, V., Vlasenko, M., Zlova, T., Zub, L., Abusnana, S., Railey, M., Abouglila, K., Ainsworth, P., Ali, Z., Arutchelvam, V., Barnard, M., Bellary, S., Davies, E., Davies, M., Davies, S., Dawson, A., Kossi, M. E., English, P., Fraser, D., Gnudi, L., Gunstone, A., Hall, T., Hanif, W., Jackson, A., Johnson, A., Joseph, F., Krishnan, S., Kumwenda, M., Macdougall, I., Nixon, P., O'Hare, J., Philip, S., Ramtoola, S., Saxena, M., Sennik, D., Simon, G., Singh, B., Stephens, J., Strzelecka, A., Symonds, R., Turner, W., Wahba, M., Wakeling, J., Wheeler, D., Winocour, P., Abdallah, J., Abdullah, R., Abramowitz, M., Acosta, I., Aiello, J., Akright, L., Akyea-Djamson, A., Alappan, R., Alicic, R., Al-Karadsheh, A., Allison, D. C., Arauz-Pacheco, C., Arfeen, S., Arif, A., Arvind, M., Atray, N., Awad, A., Bakris, G., Barnhill, P., Barranco, E., Barrera, C., Beacom, M., Behara, V., Belo, D., Bentley-Lewis, R., Berenguer, R., Bermudez, L., Bernardo, M., Biscoveanu, M., Bowman-Stroud, C., Brandon, D., Brusco, O., Busch, R., Canaan, Y., Chilito, A., Christensen, T., Christiano, C., Christofides, E., Chuateco, C., Cohen, K., Cohen, R., Cohen-Stein, D., Cook, C., Coyne, D., Daboul, N., Darwish, R., Daswani, A., Deck, K., Desouza, C., Dev, D., Dhillon, M., Dua, S., Eder, F., Elosegui, A. 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K., Obialo, C., Olelewe, S., Oliver, M., O'Shaughnessy, A., Padron, J., Pankhaniya, R., Parker, R., Patel, D., Patel, G., Patel, N., Pavon, H., Perez, A., Perez, C., Perlman, A., Pettis, K., Pharr, W., Phillips, A., Purighalla, R., Quesada-Suarez, L., Ranjan, R., Rastogi, S., Rendell, M., Rich, L., Robinson, M., Rodriguez, H., Rosas, S., Saba, F., Sankaram, R., Sarin, R., Schreiman, R., Scott, D., Sekkarie, M., Sensenbrenner, J., Shakeel, M., Shanik, M., Shaw, S., Smith, S., Solomon, R., Sprague, A., Spry, L., Suchinda, P., Sultan, S., Surampudi, P., Sussman, S., Tan, A., Terrelonge, A., Thompson, M., Trespalacios, F., Trippe, B., Trueba, P., Twahirwa, M., Updegrove, J., Van Buren, P., Vannorsdall, M., Varghese, F., Velasquez-Mieyer, P., Ventrapragada, S., Vukotic, G., Wadud, K., Warren, M., Watson, H., Watts, R., Weiner, D., Welker, J., Welsh, J., Williams, S., Zaniewski-Singh, M., Groningen Kidney Center (GKC), Zhou, Z, Jardine, M, Li, Q, Neuen, B, Cannon, C, De Zeeuw, D, Edwards, R, 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Haase, F, Diaz, J, Roca, L, Arenales, J, Polo, J, Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Oomman, A, Raju, S, Dewan, D, Fernando, M, Gopalakrishnan, N, Gracious, N, Alva, H, Jain, D, Keshavamurthy, C, Khullar, D, Sahay, M, Peringat, J, Prasad, N, Rao, K, Reddy, S, Melemadathil, S, Sudhakar, B, Vyasam, R, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, De Nicola, L, Derosa, G, Carlo, A, Cianni, G, Frasca, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, F, Serviddio, G, Stella, A, Trevisan, R, Veronelli, A, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T, Kajiyama, S, Kashine, S, Kawada, T, Kodera, T, Kono, H, Koyama, K, Kumeda, Y, Miyauchi, S, Mizuyama, K, Niiya, T, Oishi, H, Ota, S, Sakakibara, T, Takai, M, Tomonaga, O, Tsujimoto, M, Wada, T, Wakasugi, M, Wakida, Y, Watanabe, T, Yamada, M, Yanagida, K, Yanase, T, Yumita, W, Gaupsiene, E, Kozloviene, D, Navickas, A, Urbanaviciene, E, Ghani, R, Kadir, K, Ali, N, Yusof, M, Gan, C, Ismail, M, Kong, W, Lam, S, Lee, L, Lim, S, Loh, C, Manocha, A, Ng, K, Ahmad, N, Ratnasingam, V, Shudim, S, Vengadasalam, P, Munoz, L, Salazar, M, Cruz, J, Soto, M, Ramos, J, Wong, A, Rotter, J, Escalante, T, Sosa, F, Lozano, F, Cervera, L, Baron, P, Ballesteros, C, Rangel, J, Jimenez, L, Santana, S, Flores, F, Molina, H, Ceballos, R, Del Campo Blanco, B, Franco, G, Loza, O, Rocha, C, Vera, G, Castellanos, R, Calcaneo, J, Rosano, M, Pattzi, H, Guzman, J, Joerg, I, Sanchez, S, Mijangos, J, Sanson, P, Tamayo Y Orozco, J, Chavez, E, Cepeda, A, Carrillo, L, Mesa, J, Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, E, Williams, M, Young, S, Abejuela, Z, Agra, J, Aquitania, G, Caringal, C, Comia, R, Santos, L, Gomez, O, Jimeno, C, Santos, F, Tan, G, Tolentino, M, Yao, C, Yap, Y, Ygpuara, M, Bijata-Bronisz, R, Hotlos, L, Januszewicz, A, Kaczmarek, B, Kaminska, A, Lazuka, L, Madej, A, Mazur, S, Mlodawska-Choluj, D, Nowicki, M, Orlowska-Kowalik, G, Popenda, G, Rewerska, B, Sowinski, D, Angelescu, L, Anghel, V, Avram, R, Busegeanu, M, Cif, A, Cosma, D, Crisan, C, Demian, L, Ferariu, I, Halmagyi, I, Hancu, N, Munteanu, M, Negru, D, Onaca, A, Petrica, L, Popa, A, Ranetti, A, Serafinceanu, C, Toarba, C, Agafyina, A, Barbarash, O, Barysheva, O, Chizhov, D, Dobronravov, V, Dreval, A, Glinkina, I, Grineva, E, Khirmanov, V, Kolmakova, E, Koroleva, T, Kvitkova, L, Marasaev, V, Mkrtumyan, A, Morugova, T, Nagibovich, G, Nagibovich, O, Nedogoda, S, Osipova, I, Raskina, T, Samoylova, Y, Sazonova, O, Shamkhalova, M, Shutemova, E, Shwartz, Y, Uriasyev, O, Vorobyev, S, Zateyshchikova, A, Zateyshshikov, D, Zykova, T, Antic, S, Djordjevic, M, Kendereski, A, Lalic, K, Lalic, N, Popovic-Radinovic, V, Babikova, J, Benusova, O, Buganova, I, Culak, J, Dzupina, A, Dzuponova, J, Fulop, P, Ilavska, A, Martinka, E, Ochodnicka, Z, Pella, D, Smatanova, I, Ahmed, F, Badat, A, Breedt, J, Distiller, L, Govender, V, Govender, R, Joshi, M, Jurgens, J, Latiff, G, Lombard, L, Mookadam, M, Ngcakani, N, Nortje, H, Oosthuizen, H, Pillay-Ramaya, L, Prozesky, H, Reddy, J, Rheeder, P, Seeber, M, Chae, D, Cho, Y, Jeong, I, Kim, S, Kim, Y, Kwon, H, Kwon, M, Lee, B, Lee, J, Lee, M, Nam, M, Oh, K, Park, C, Park, S, Yoon, K, Garcia, P, Mercadal, L, Barrios, C, Castro, F, Guldris, S, Lopez, M, De Los Rios, J, Fresnedo, G, Serrano, A, Garcia, I, Martinez, F, Gimeno, J, Mendoza, M, Marin, T, Portillo, C, Vila, M, Torres, M, Iglesias, J, Perez, J, Vera, M, Simon, M, Canonge, R, Riera, M, Madueno, F, Plaza, M, Chang, C, Chuang, L, Hsia, T, Hsieh, C, Hwang, S, Lin, C, Lu, Y, Sheu, W, Barna, O, Bilyk, S, Botsyurko, V, Dudar, I, Fushtey, I, Godlevska, O, Golovchenko, O, Gyrina, O, Kazmirchuk, A, Kolesnyk, M, Komisarenko, I, Korzh, O, Kravchun, N, Legun, O, Mankovskyy, B, Martynyuk, L, Mostovoy, Y, Pashkovska, N, Pererva, L, Pertseva, T, Samoylov, O, Smirnov, I, Svyshchenko, Y, Tomashkevych, H, Topchii, I, Tryshchuk, N, Tseluyko, V, Vizir, V, Vlasenko, M, Zlova, T, Zub, L, Abusnana, S, Railey, M, Abouglila, K, Ainsworth, P, Ali, Z, Arutchelvam, V, Barnard, M, Bellary, S, Davies, E, Davies, M, Davies, S, Dawson, A, Kossi, M, English, P, Fraser, D, Gnudi, L, Gunstone, A, Hall, T, Hanif, W, Jackson, A, Johnson, A, Joseph, F, Krishnan, S, Kumwenda, M, Macdougall, I, Nixon, P, O'Hare, J, Philip, S, Ramtoola, S, Saxena, M, Sennik, D, Simon, G, Singh, B, Stephens, J, Strzelecka, A, Symonds, R, Turner, W, Wahba, M, Wakeling, J, Wheeler, D, Winocour, P, Abdallah, J, Abdullah, R, Abramowitz, M, Acosta, I, Aiello, J, Akright, L, Akyea-Djamson, A, Alappan, R, Alicic, R, Al-Karadsheh, A, Allison, D, Arauz-Pacheco, C, Arfeen, S, Arif, A, Arvind, M, Atray, N, Awad, A, Bakris, G, Barnhill, P, Barranco, E, Barrera, C, Beacom, M, Behara, V, Belo, D, Bentley-Lewis, R, Berenguer, R, Bermudez, L, Bernardo, M, Biscoveanu, M, Bowman-Stroud, C, Brandon, D, Brusco, O, Busch, R, Canaan, Y, Chilito, A, Christensen, T, Christiano, C, Christofides, E, Chuateco, C, Cohen, K, Cohen, R, Cohen-Stein, D, Cook, C, Coyne, D, Daboul, N, Darwish, R, Daswani, A, Deck, K, Desouza, C, Dev, D, Dhillon, M, Dua, S, Eder, F, Elosegui, A, El-Shahawy, M, Ervin, J, Esquenazi, A, Evans, J, Fishbane, S, Frias, J, Galindo-Ramos, E, Galphin, C, Ghazi, A, Gonzalez, E, Gorson, D, Gowda, A, Greco, B, Grubb, S, Gulati, R, Hammoud, J, Handelsman, S, Hartman, I, Hershon, K, Hiser, D, Hon, G, Jacob, R, Jaime, M, Jamal, A, Kaupke, C, Keightley, G, Kern, E, Khanna, R, Khitan, Z, Kopyt, N, Kovesdy, C, Krishna, G, Kropp, J, Kumar, A, Kumar, J, Kumar, N, Kusnir, J, Lane, W, Lawrence, M, Lehrner, L, Lentz, J, Levinson, D, Lewis, D, Liss, K, Maddux, A, Maheshwari, H, Mandayam, S, Marar, I, Mehta, B, Middleton, J, Mordujovich, J, Moreda, R, Moustafa, M, Trenche, S, Narayanan, M, Narvarte, J, Nassar, T, Newman, G, Nichol, B, Nicol, P, Nisnisan, J, Nossuli, A, Obialo, C, Olelewe, S, Oliver, M, O'Shaughnessy, A, Padron, J, Pankhaniya, R, Parker, R, Patel, D, Patel, G, Patel, N, Pavon, H, Perez, A, Perez, C, Perlman, A, Pettis, K, Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, and Zaniewski-Singh, M
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medicine.medical_specialty ,Original Contributions ,atrial fibrillation ,canagliflozin ,glomerular filtration rate ,hemorrhagic stroke ,ischemic stroke ,Renal function ,Disease ,Brain Ischemia ,Clinical and Population Sciences ,Meta-Analysis as Topic ,Internal medicine ,CREDENCE Trial Investigators ,Atrial Fibrillation ,medicine ,Diabetes Mellitus ,Humans ,Diabetic Nephropathies ,Canagliflozin ,Stroke ,1102 Cardiorespiratory Medicine and Haematology ,Sodium-Glucose Transporter 2 Inhibitors ,Advanced and Specialized Nursing ,Neurology & Neurosurgery ,business.industry ,Atrial fibrillation ,1103 Clinical Sciences ,medicine.disease ,Diabetes Mellitus, Type 2 ,Meta-analysis ,Cardiology ,Albuminuria ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Neurology (clinical) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,1109 Neurosciences ,Kidney disease ,medicine.drug - Abstract
Supplemental Digital Content is available in the text., Background and Purpose: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. Methods: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis. Results: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55–1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61–1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19–1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20–1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53–1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82–1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89–1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30–0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49–1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71–0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (
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- 2021
19. Toward a unified metric of kinetic and nonkinetic actions: meaning fields and the arc of effects
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DeWees, Bradley, Pierce, Terry C., Rokke, Ervin J., and Tingle, Anthony
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National security -- Management ,Company business management ,Military and naval science - Abstract
There is a critical need for new thinking on how the United States can better meet the full spectrum of kinetic and nonkinetic 21st-century security challenges. Revolutionary changes in information [...]
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- 2017
20. Gender differences in the association between unpaid labour and mental health in employed adults: a systematic review
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Ervin, J, Taouk, Y, Alfonzo, LF, Hewitt, B, King, T, Ervin, J, Taouk, Y, Alfonzo, LF, Hewitt, B, and King, T
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Globally, billions of hours are spent on unpaid labour every year, a burden that is disproportionately carried by women. However, the potential health effects of unpaid labour have largely been unexplored. This Review examines the gendered association between unpaid labour and mental health among employed adults. We did a search of six databases and examined the association between different forms of unpaid labour and mental health. 19 studies (totalling 70 310 participants) were included. We found substantial heterogeneity, and low-to-moderate methodological quality, in the existing research. Our Review indicates substantial gender differences in exposure to unpaid labour and confirms persistent inequities in the division of unpaid work. Overall, our findings indicate that, among employed adults, unpaid labour is negatively associated with women's mental health, with effects less apparent for men. Globally, women spend a greater number of hours on unpaid labour; this review suggests that inequities in the division of unpaid labour expose women to greater risk of poorer mental health than men.
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- 2022
21. Mental health of young informal carers: a systematic review
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Alfonzo, LF, Singh, A, Disney, G, Ervin, J, King, T, Alfonzo, LF, Singh, A, Disney, G, Ervin, J, and King, T
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PURPOSE: This systematic review aims to assess and evaluate quantitative evidence on the association between informal caregiving and mental health in young people. METHODS: This review was registered in PROSPERO (CRD42021251666). We conducted our search in the following four databases: Medline (PubMed and OVID), EMBASE, PsycInfo and Web of Science. The last search was performed on the 17th of March of 2021. Quantitative studies that focused on carers aged 25 years or less and compared the mental health status of carers and non-carers were eligible for inclusion. Two reviewers independently assessed articles for eligibility and performed the quality assessment using the Risk of Bias tool in Non-Randomised Studies of Exposures (ROBINS-E). RESULTS: We identified a total of ten eligible articles. Mental health outcomes included depression, anxiety and other mental or emotional problems. Nine out of the ten studies showed that being a young carer was consistently associated with poor mental health. However, the overall quality of evidence was low, and longitudinal data were limited to three articles. The primary sources of bias were confounding and outcome measurement. CONCLUSION: Young carers experience poorer mental health outcomes than their non-caring peers. However, we identified an overall lack of quantitative evidence of high methodological rigour. To establish if young caring leads to poor mental health, future research should focus on addressing the identified methodological limitations and understanding the mechanisms explaining these associations. Addressing these gaps can better inform the allocation of appropriate support and resources to optimise the mental health of young carers.
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- 2022
22. Longitudinal association between informal unpaid caregiving and mental health amongst working age adults in high-income OECD countries: A systematic review
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Ervin, J, Taouk, Y, Alfonzo, LF, Peasgood, T, King, T, Ervin, J, Taouk, Y, Alfonzo, LF, Peasgood, T, and King, T
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BACKGROUND: Informal unpaid caregivers provide most of the world's care needs, experiencing numerous health and wealth penalties as a result. As the COVID-19 pandemic has highlighted, informal care is highly gendered. Longitudinal evidence is needed to assess the causal effect of caregiving on mental health. This review addresses a gap by summarising and appraising the longitudinal evidence examining the association between unpaid caregiving and mental health among working age adults in high-income Organisation for Economic Co-operation and Development (OECD) countries and examining gender differences. METHODS: Six databases were searched (Medline, PsycInfo, EMBASE, Scopus, Web of Science, Econlit) from Jan 1, 2000 to April 1, 2022. Population-based, peer-reviewed quantitative studies using any observational design were included. Population of interest was working age adults. Exposure was any unpaid caregiving, and studies must have had a non-caregiving comparator for inclusion. Mental health outcomes (depression, anxiety, psychological distress/wellbeing) were measurable by validated self-report tools or professional diagnosis. Screening, data extraction and quality assessment (ROBINS-E) were conducted by two reviewers. The study was prospectively registered with PROSPERO (CRD42022312401). FINDINGS: Of the 4536 records screened; 13 eligible studies (133,426 participants) were included. Overall quality of evidence was moderate. Significant between-study heterogeneity precluded meta-analysis, so albatross and effect-direction plots complement the narrative synthesis. Results indicate a negative association between informal unpaid care and mental health in adults of working age. Importantly, all included studies were longitudinal in design. Where studies were stratified by gender, caregiving had a consistently negative impact on the mental health of women. Few studies examined men but revealed a negative effect where an association was found. INTERPRETATION: Our revie
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- 2022
23. Mental health of young informal carers: a systematic review (Jul, 10.1007/s00127-022-02333-8, 2022)
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Fleitas Alfonzo, L, Singh, A, Disney, G, Ervin, J, King, T, Fleitas Alfonzo, L, Singh, A, Disney, G, Ervin, J, and King, T
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- 2022
24. Virtual environment for remote access and automation of an AC motor in a web-based laboratory
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García-Guzmán, Jesus, Villa-L–pez, Farah H., Silva-Del-Rosario, Francisco H., Ramírez-Ramírez, Alfredo, Enríquez, Jorge V.élez, and Álvarez-Sánchez, Ervin J.
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- 2012
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25. Crafting and managing effects: the evolution of the profession of arms
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Stavridis, James G., Rokke, Ervin J., and Pierce, Terry C.
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Sony Corp. -- Management ,Sony Pictures Entertainment Inc. -- Management ,Consumer electronics industry ,Computer crimes ,Video production companies ,Consumer electronics industry ,Company business management ,Computer crime ,Military and naval science - Abstract
Recent operations conducted against U.S. businesses and citizens have reemphasized a critical vulnerability in how the U.S. Government thinks about and defends itself against nonkinetic instruments of power. This is [...]
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- 2016
26. Humid Regions
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Van Doren, David M., primary, Barrows, Harold L., additional, Engelstad, Orvis P., additional, Foster, G. R., additional, Koos, Ervin J. J., additional, Langdale, George W., additional, Lucey, Robert F., additional, Mannering, Jerry V., additional, Martin, William P., additional, Mayo, Z. B., additional, Orth, Paul G., additional, Osborne, Gary, additional, Ryan, James A., additional, Seitz, W. D., additional, and Smith, Albert E., additional
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- 2015
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27. Compact modeling of a PD SOI MESFET for wide temperature designs
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Balijepalli, A., Ervin, J., Lepkowski, W., Cao, Y., and Thornton, T.J.
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- 2009
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28. Energy and the Consumer: The Risks of Revolution
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Cawley, Charles N. and Fenyves, Ervin J.
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- 1980
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29. The Large Municipal Library as a Network
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Gaines, Ervin J.
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- 1969
30. Effect of Gamma and Proton Irradiation on Lactic Dehydrogenase Isoenzymes
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Hawrylewicz, Ervin J. and Blair, William H.
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- 1966
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31. The SuperCam Instrument Suite on the Mars 2020 Rover:Science Objectives and Mast-Unit Description
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Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J. M., Deleuze, M., Rull, F., Manrique, J. A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J. P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J. C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q. M., Legett, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J. F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H. C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., Wong, K. W., Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J. M., Deleuze, M., Rull, F., Manrique, J. A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J. P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J. C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q. M., Legett, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J. F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H. C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., and Wong, K. W.
- Abstract
On the NASA 2020 rover mission to Jezero crater, the remote determination of the texture, mineralogy and chemistry of rocks is essential to quickly and thoroughly characterize an area and to optimize the selection of samples for return to Earth. As part of the Perseverance payload, SuperCam is a suite of five techniques that provide critical and complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), visible and near-infrared spectroscopy (VISIR), high-resolution color imaging (RMI), and acoustic recording (MIC). SuperCam operates at remote distances, primarily 2–7 m, while providing data at sub-mm to mm scales. We report on SuperCam’s science objectives in the context of the Mars 2020 mission goals and ways the different techniques can address these questions. The instrument is made up of three separate subsystems: the Mast Unit is designed and built in France; the Body Unit is provided by the United States; the calibration target holder is contributed by Spain, and the targets themselves by the entire science team. This publication focuses on the design, development, and tests of the Mast Unit; companion papers describe the other units. The goal of this work is to provide an understanding of the technical choices made, the constraints that were imposed, and ultimately the validated performance of the flight model as it leaves Earth, and it will serve as the foundation for Mars operations and future processing of the data.
- Published
- 2021
32. Anthropogenic modification of forests means only 40% of remaining forests have high ecosystem integrity
- Author
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Grantham, H. S., Duncan, A., Evans, T. D., Jones, K. R., Beyer, H. L., Schuster, R., Walston, J., Ray, J. C., Robinson, J. G., Callow, M., Clements, T., Costa, H. M., DeGemmis, A., Elsen, P. R., Ervin, J., Franco, P., Goldman, E., Goetz, S., Hansen, A., Hofsvang, E., Jantz, P., Jupiter, S., Kang, A., Langhammer, P., Laurance, W. F., Lieberman, S., Linkie, M., Malhi, Y., Maxwell, S., Mendez, M., Mittermeier, R., Murray, N. J., Possingham, H., Radachowsky, J., Saatchi, S., Samper, C., Silverman, J., Shapiro, A., Strassburg, B., Stevens, T., Stokes, E., Taylor, R., Tear, T., Tizard, R., Venter, O., Visconti, P., Wang, S., Watson, J. E. M., Grantham, H. S., Duncan, A., Evans, T. D., Jones, K. R., Beyer, H. L., Schuster, R., Walston, J., Ray, J. C., Robinson, J. G., Callow, M., Clements, T., Costa, H. M., DeGemmis, A., Elsen, P. R., Ervin, J., Franco, P., Goldman, E., Goetz, S., Hansen, A., Hofsvang, E., Jantz, P., Jupiter, S., Kang, A., Langhammer, P., Laurance, W. F., Lieberman, S., Linkie, M., Malhi, Y., Maxwell, S., Mendez, M., Mittermeier, R., Murray, N. J., Possingham, H., Radachowsky, J., Saatchi, S., Samper, C., Silverman, J., Shapiro, A., Strassburg, B., Stevens, T., Stokes, E., Taylor, R., Tear, T., Tizard, R., Venter, O., Visconti, P., Wang, S., and Watson, J. E. M.
- Abstract
Many global environmental agendas, including halting biodiversity loss, reversing land degradation, and limiting climate change, depend upon retaining forests with high ecological integrity, yet the scale and degree of forest modification remain poorly quantified and mapped. By integrating data on observed and inferred human pressures and an index of lost connectivity, we generate a globally consistent, continuous index of forest condition as determined by the degree of anthropogenic modification. Globally, only 17.4 million km2 of forest (40.5%) has high landscape-level integrity (mostly found in Canada, Russia, the Amazon, Central Africa, and New Guinea) and only 27% of this area is found in nationally designated protected areas. Of the forest inside protected areas, only 56% has high landscape-level integrity. Ambitious policies that prioritize the retention of forest integrity, especially in the most intact areas, are now urgently needed alongside current efforts aimed at halting deforestation and restoring the integrity of forests globally.
- Published
- 2021
33. Combined effects power
- Author
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Rokke, Ervin J., Drohan, Thomas A., and Pierce, Terry C.
- Subjects
Electronic warfare -- Analysis ,Combined arms (Military science) -- Analysis ,Military and naval science - Abstract
The information revolution continues to recast how power is generated and how it can be used to achieve desired outcomes. Advanced technologies and novel communication tools are enabling individual and [...]
- Published
- 2014
34. Only 40% of the world’s forests are in good health
- Author
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Grantham, H.S., Duncan, A., Evans, T. D., Jones, K., Beyer, H., Shuster, R., Walston, J., Ray, J., Robinson, J., Callow, M., Clements, T., Costa, H., DeGemmis, A., Elsen, P., Ervin, J., Franco, P., Goldman, E., Goetz, S., Hansen, A., Hofsvang, E., Jantz, P., Jupiter, S., Kang, A., Langhammer, P., Laurance, W.F., Lieberman, S., Linkie, M., Malhi, Y., Maxwell, S., Mendez, M., Mittermeier, R., Murray, N., Possingham, H., Radachowsky, J., Samper, C., Silverman, J., Shapiro, A., Strassburg, B., Stevens, T., Stokes, E., Taylor, R., Tear, T., Tizard, R., Venter, O., Visconti, P., Wang, S., and Watson, J.E.M.
- Abstract
Many global environmental agendas, including halting biodiversity loss, reversing land degradation, and limiting climate change, depend upon retaining forests with high ecological integrity, yet the scale and degree of forest modification remains poorly quantified and mapped. By integrating data on direct and indirect forest pressures and lost forest connectivity, we generate the first globally-consistent, continuous index of forest condition as determined by degree of anthropogenic modification, which we term ‘forest health’. Globally, only 17.4 million km 2 of forest (40.5%) can be considered in high health (mostly found in Canada, Russia, the Amazon, Central Africa and New Guinea) and only 27% of this area is found in nationally-designated protected areas. Of all the world’s forests found within protected areas, only 56% can be considered in high health. Ambitious policies that prioritize the retention of forest health are now urgently needed alongside current efforts aimed at restoring the health of forests globally.
- Published
- 2020
- Full Text
- View/download PDF
35. Protecting 30% of the planet for nature: costs, benefits, and economic implications: Working paper analysing the economic implications of the proposed 30% target for areal protection in the draft post-2020 Global Biodiversity Framework
- Author
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Waldron, A., Adams, V., Allan, J., Arnell, A., Atkinson, S., Baccini, A., Baillie, J.E.M., Balmford, A., Beau, J.A., Brander, L., Brondizio, E., Bruner, A., Burgess, N., Burkart, K., Butchart, S., Button, R., Carasco, R., Cheung, W., Christensen, V., Clements, A., Coll, M., Di Marco, M., Deguignet, M., Dinerstein, E., Ellis, E., Eppink, F., Ervin, J., Escobedo, A., Fa, J., Fernandes-Llamazares, A., Fernando, S., Fujimori, S., Fulton, B., Garnett, S., Gerber, J., Gill, D., Gopalakrishna, T., Hahn, N., Halpern, B., Hasegawa, T., Havlik, P., Heikinheimo, V., Heneghan, R., Henry, E., Humpenoder, F., Jonas, H., Jones, K., Joppa, L., Joshi, A.R., Jung, M., Kingston, N., Klein, C., Krisztin, T., Lam, V., Leclere, D., Lindsey, P., Locke, H., Lovejoy, T.E., Madgwick, P., Malhi, Y., Malmer, P., Maron, M., Mayorga, J., van Meijl, H., Miller, D., Molnar, Z., Mueller, N., Mukherjee, N., Naidoo, R., Nakamura, K., Nepal, P., Noss, R.F., O’Leary, B., Olson, D., Palcios Abrantes, J., Paxton, M., Popp, A., Possingham, H., Prestemon, J., Reside, A., Robinson, C., Robinson, J., Sala, E., Scherrer, K., Spalding, M., Spenceley, A., Steenbeck, J., Stehfest, E., Strassborg, B., Sumaila, R., Swinnerton, K., Sze, J., Tittensor, D., Toivonen, T., Toledo, A., Negret Torres, P., van Zeist, W.-J., Vause, J., Venter, O., Vilela, T., Visconti, P., Vynne, C., Watson, R., Watson, J., Wikramanayake, E., Williams, B., Wintle, B., Woodley, S., Wu, W., Zander, K., Zhang, Y., Zhang, Y.P., and Theoretical and Computational Ecology (IBED, FNWI)
- Abstract
The World Economic Forum (WEF) and Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) have both identified biodiversity loss as one of the main threats to global economic prosperity. In particular, this high-level warning specifies that any further loss of natural habitats and biodiversity will cause extensive and costly flooding, climate change, disease emergence and ill health, clean water shortages, loss of crop pollination, decline in productivity, and numerous other risks. All of these negative outcomes are the consequence of degrading the natural infrastructure that supports human economic activity and wellbeing. One of the main policy instruments to slow the loss of biodiversity and the degradation of nature is the creation of protected or conservation areas (simple examples being a Nature Reserve or Marine Reserve). Currently, ~16% of the land and 7.4% of the ocean is in areas designated or proposed for protection (although only 2.5% of the ocean is in highly/fully protected areas). This level of protection is widely acknowledged as being inadequate to achieve biodiversity protection goals. One of the headline proposals for the 15th meeting of the Conference of Parties to the CBD, and Action Target 2 of the draft post-2020 Global Biodiversity Framework, is to increase the area covered by protected areas (PAs) and other effective area-based conservation measures (OECMs) to 30% of the planet by 2030, including both land and water protection.
- Published
- 2020
36. Protecting 30% of the planet for nature: costs, benefits and economic implications
- Author
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Waldron, A., Adams, V., Allan, J., Arnell, A., Asner, G., Atkinson, S., Baccini, A., Baillie, J., Balmford, A., Austin Beau, J., Brander, L., Brondizio, E., Bruner, A., Burgess, N., Burkart, K., Butchart, S., Button, R., Carrasco, R., Cheung, W., Christensen, V., Clements, A., Coll, M., di Marco, M., Deguignet, M., Dinerstein, E., Ellis, E., Eppink, F., Ervin, J., Escobedo, A., Fa, J., Fernandes-Llamazares, A., Fernando, S., Fujimori, S., Fulton, B., Garnett, S., Gerber, J., Gill, D., Gopalakrishna, T., Hahn, N., Halpern, B., Hasegawa, T., Havlik, P., Heikinheimo, V., Heneghan, R., Henry, E., Humpenoder, F., Jonas, H., Jones, K., Joppa, L., Joshi, A., Jung, M., Kingston, N., Klein, C., Krisztin, T., Lam, V., Leclere, D., Lindsey, P., Locke, H., Lovejoy, T., Madgwick, P., Malhi, Y., Malmer, P., Maron, M., Mayorga, J., van Meijl, H., Miller, D., Molnar, Z., Mueller, N., Mukherjee, N., Naidoo, R., Nakamura, K., Nepal, P., Noss, R., O’Leary, B., Olson, D., Palcios Abrantes, J., Paxton, M., Popp, A., Possingham, H., Prestemon, J., Reside, A., Robinson, C., Robinson, J., Sala, E., Scherrer, K., Spalding, M., Spenceley, A., Steenbeck, J., Stehfest, E., Strassborg, B., Sumaila, R., Swinnerton, K., Sze, J., Tittensor, D., Toivonen, T., Toledo, A., Negret Torres, P., Van Zeist, W., Vause, J., Venter, O., Vilela, T., Visconti, P., Vynne, C., Watson, R., Watson, J., Wikramanayake, E., Williams, B., Wintle, B., Woodley, S., Wu, W., Zander, K., Zhang, Y., Waldron, A., Adams, V., Allan, J., Arnell, A., Asner, G., Atkinson, S., Baccini, A., Baillie, J., Balmford, A., Austin Beau, J., Brander, L., Brondizio, E., Bruner, A., Burgess, N., Burkart, K., Butchart, S., Button, R., Carrasco, R., Cheung, W., Christensen, V., Clements, A., Coll, M., di Marco, M., Deguignet, M., Dinerstein, E., Ellis, E., Eppink, F., Ervin, J., Escobedo, A., Fa, J., Fernandes-Llamazares, A., Fernando, S., Fujimori, S., Fulton, B., Garnett, S., Gerber, J., Gill, D., Gopalakrishna, T., Hahn, N., Halpern, B., Hasegawa, T., Havlik, P., Heikinheimo, V., Heneghan, R., Henry, E., Humpenoder, F., Jonas, H., Jones, K., Joppa, L., Joshi, A., Jung, M., Kingston, N., Klein, C., Krisztin, T., Lam, V., Leclere, D., Lindsey, P., Locke, H., Lovejoy, T., Madgwick, P., Malhi, Y., Malmer, P., Maron, M., Mayorga, J., van Meijl, H., Miller, D., Molnar, Z., Mueller, N., Mukherjee, N., Naidoo, R., Nakamura, K., Nepal, P., Noss, R., O’Leary, B., Olson, D., Palcios Abrantes, J., Paxton, M., Popp, A., Possingham, H., Prestemon, J., Reside, A., Robinson, C., Robinson, J., Sala, E., Scherrer, K., Spalding, M., Spenceley, A., Steenbeck, J., Stehfest, E., Strassborg, B., Sumaila, R., Swinnerton, K., Sze, J., Tittensor, D., Toivonen, T., Toledo, A., Negret Torres, P., Van Zeist, W., Vause, J., Venter, O., Vilela, T., Visconti, P., Vynne, C., Watson, R., Watson, J., Wikramanayake, E., Williams, B., Wintle, B., Woodley, S., Wu, W., Zander, K., and Zhang, Y.
- Abstract
Working paper analysing the economic implications of the proposed 30% target for areal protection in the draft post-2020 Global Biodiversity Framework
- Published
- 2020
37. Quantifying Protein Folding Transition States with ΦT
- Author
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Ervin, J. and Gruebele, M.
- Published
- 2002
- Full Text
- View/download PDF
38. Large-signal modeling of SOI MESFETs
- Author
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Balijepalli, A., Vijayaraghavan, R., Ervin, J., Yang, J., Islam, S.K., and Thornton, T.J.
- Published
- 2006
- Full Text
- View/download PDF
39. Formation of a compact structured ensemble without fluorescence signature early during ubiquitin folding
- Author
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Qin, Z., Ervin, J., Larios, E., Gruebele, M., and Kihara, H.
- Subjects
Spectrum analysis -- Usage ,Viscosity -- Observations ,Ubiquitin -- Thermal properties ,Ubiquitin -- Structure ,Chemicals, plastics and rubber industries - Abstract
The fluorescent Phe45Trp (Ub*) mutant of the small globular protein ubiquitin is studied by multiple spectroscopic techniques under low temperature/high viscosity conditions to reveal unambiguously the formation of a compact structured intermediate preceding the barrier crossing to the native state. Ubiquitin appears to fold via a quasi two-state mechanism when detected by fluorescence intensity alone.
- Published
- 2002
40. Tidal Volumes Upon Initiation of Invasive Ventilation: The Who, What, When, and Where
- Author
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Ervin, J., primary, Haas, C.F., additional, Yuan, M., additional, and Sjoding, M.W., additional
- Published
- 2020
- Full Text
- View/download PDF
41. Prioritizing Evidence-Based Practices Using Digital Data: An Iterative Process with Domain Experts and Stakeholders
- Author
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Ervin, J., primary, Dibble, E., additional, Rentes, V.C., additional, Sjoding, M.W., additional, Gong, M.N., additional, Hough, C.T.L., additional, Iwashyna, T.J., additional, and Sales, A.E., additional
- Published
- 2020
- Full Text
- View/download PDF
42. Design of a Phase 1 Virtual Hybrid Study of AZD7594, an Inhaled Non-Steroidal, Selective Glucocorticoid Receptor Modulator, in Adolescents with Asthma
- Author
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Necander, S., primary, Lawrence, S., additional, Thurman, L., additional, Ervin, J., additional, Acosta, I., additional, Björnsson, E., additional, Prothon, S., additional, Whälby Hamrén, U., additional, Jauhiainen, A., additional, Brown, M., additional, Valastro, B., additional, Forsman, H., additional, Arfvidsson, C., additional, Steele, J., additional, and Psallidas, I., additional
- Published
- 2020
- Full Text
- View/download PDF
43. Time-Limited Trials in the ICU for Older Patients: A Multi-Method Study of Intensivists at Two Academic Centers
- Author
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Ervin, J., primary, Viglianti, E.M., additional, Newton, C., additional, Iwashyna, T.J., additional, and Valley, T.S., additional
- Published
- 2020
- Full Text
- View/download PDF
44. Evidence Based Practices in the Continuum of Care for Mechanically Ventilated Patients: A Review of Reviews
- Author
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Ervin, J., primary, Rentes, V.C., additional, Dibble, E., additional, Sjoding, M.W., additional, Hough, C.T.L., additional, Iwashyna, T.J., additional, Gong, M.N., additional, and Sales, A.E., additional
- Published
- 2020
- Full Text
- View/download PDF
45. Modification of forests by people means only 40% of remaining forests have high ecosystem integrity
- Author
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Grantham, H.S., primary, Duncan, A., additional, Evans, T. D., additional, Jones, K., additional, Beyer, H., additional, Schuster, R., additional, Walston, J., additional, Ray, J., additional, Robinson, J., additional, Callow, M., additional, Clements, T., additional, Costa, H.M., additional, DeGemmis, A., additional, Elsen, P.R., additional, Ervin, J., additional, Franco, P., additional, Goldman, E., additional, Goetz, S., additional, Hansen, A., additional, Hofsvang, E., additional, Jantz, P., additional, Jupiter, S., additional, Kang, A., additional, Langhammer, P., additional, Laurance, W.F., additional, Lieberman, S., additional, Linkie, M., additional, Malhi, Y., additional, Maxwell, S., additional, Mendez, M., additional, Mittermeier, R., additional, Murray, N., additional, Possingham, H., additional, Radachowsky, J., additional, Samper, C., additional, Silverman, J., additional, Shapiro, A., additional, Strassburg, B., additional, Stevens, T., additional, Stokes, E., additional, Taylor, R., additional, Tear, T., additional, Tizard, R., additional, Venter, O., additional, Visconti, P., additional, Wang, S., additional, and Watson, J.E.M., additional
- Published
- 2020
- Full Text
- View/download PDF
46. A Benchmark Study of Complementary-Field Effect Transistor (CFET) Process Integration Options Done by Virtual Fabrication
- Author
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Vincent, B., primary, Boemmels, J., additional, Ryckaert, J., additional, and Ervin, J., additional
- Published
- 2020
- Full Text
- View/download PDF
47. 63 Inhibition of CXCR4 at the fetal-maternal interface during placentation results in altered production of vascular endothelial growth factor receptors in the placenta on Day 90 of pregnancy
- Author
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Ervin, J. M., primary, McIntosh, S. Z., additional, Runyan, C. L., additional, and Ashley, R. L., additional
- Published
- 2020
- Full Text
- View/download PDF
48. Disulfide bonds and protein folding
- Author
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Wedemeyer, William J., Welker, Ervin J., Narayan, Mahesh, and Scheraga, Harold A.
- Subjects
Biochemistry -- Research ,Protein folding -- Research ,Sulfides -- Research ,Ribonuclease -- Research ,Biological sciences ,Chemistry - Abstract
Research has been conducted on the protein folding, structure and stability. The mechanism of reductive unfolding with ribonuclease A has been investigated.
- Published
- 2000
49. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
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Perkovic, V., Jardine, M. J., Neal, B., Bompoint, S., Heerspink, H. J. L., Charytan, D. M., Edwards, R., Agarwal, R., Bakris, G., Bull, S., Cannon, C. P., Capuano, G., Chu, P. -L., De Zeeuw, D., Greene, T., Levin, A., Pollock, C., Wheeler, D. C., Yavin, Y., Zhang, H., Zinman, B., Meininger, G., Brenner, B. M., Mahaffey, K. W., Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M, Morren, F, Goykhman, S, David, C, Yost, L, Wang, H, Hettiarachchi, M, Thimmaiah, R, Koppolu, D, George, S, Schmidt, M, Ignjatovic, J, Chapin, L, Travis, K, Destree, M, Sood, V, Coffee, L, De Brouwer, K, Zaviriukha, V, Starzec, A, Koizumi, M, Lin, G, Chen, E, Lin, P, Leia, C, Mascaro, D, Amigo, A, Limos, A, Abrahamsen, I, Jaffer, S, Ahuad Guerrero RA, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Gonzalez Colaso PDC, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, Leon de la Fuente RA, Marchetta, N, Mele, P, Nicolai, S, Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Rodriguez Papini, N, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Smith Casabella, T, Ulla, Mr, Valdez, M, Vallejos, A, Villarino, A, Visco, Ve, Wassermann, A, Zaidman, Cj, Cheung, Nw, Droste, C, Fraser, I, Johnson, D, Mah, Pm, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, Ra, Alves da Costa FA, Amodeo, C, Andreotti Turatti LA, Bregman, R, Camelo Sanches FC, Canani, Lh, Chacra, Ar, Cunha Borges JL, Cunha Vêncio SA, da Silva Franco RJ, D'Avila, D, de Souza Portes, E, de Souza, P, Deboni, Lm, Filho, Ff, Geloneze Neto, B, Gomes, M, Kohara, Sk, Keitel, E, Kerr Saraiva JF, Kurtz Lisboa HR, de Carvalho Contieri FL, Milagres, R, Montenegro Junior, R, Moreira de Brito, C, Nazzer Hissa, M, Nazario Sabbag ÂR, Noronha, I, Panarotto, D, Pecoits Filho, R, Pereira, Ma, Saporito, W, Scotton, As, Schuch, T, Simões de Almeida, R, Slompo Ramos, C, Soares Felício, J, Thomé, F, Tibes Hachmann JC, Yamada, S, Yoiti Hayashida, C, Zanata Petry TB, Zanella, Mt, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A, Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dubé, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mcmahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, N, Fernández Montenegro MA, Godoy Jorquera JG, Medina Fariña, M, Saavedra Gajardo, V, Vejar, M, Chen, N, Chen, Q, Gan, S, Kong, Y, Li, D, Li, W, Li, X, Lin, H, Liu, J, Lu, W, Mao, H, Ren, Y, Song, W, Sun, J, Sun, L, Tu, P, Wang, G, Yang, J, Yin, A, Yu, X, Zhao, M, Zheng, H, Accini Mendoza JL, Arcos, E, Avendano, J, Diaz Ruiz JEA, Garcia Ortiz LH, Gonzalez, A, Hernandez Triana, E, Higuera, Jd, Malaver, N, Molina de Salazar DI, Rosero, R, Terront Lozano MA, Valderrama Cometa, L, Valenzuela, A, Vargas Alonso RD, Villegas, I, Yupanqui, H, Bartaskova, D, Barton, P, Belobradkova, J, Dohnalova, L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, Jp, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, Pj, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Gonzalez Orellana RA, Haase, Fp, Moreira Diaz JP, Ramirez Roca LA, Sánchez Arenales JA, Sanchez Polo JV, Turcios Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Abraham, O, Bhushan, Rs, Deepak, D, Edwin, Fm, Gopalakrishnan, N, Gracious, N, Hansraj, A, Jain, D, Keshavamurthy, Cb, Khullar, D, Manisha, S, Peringat, J, 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Kravchun, N, Legun, O, Mankovskyy, B, Martynyuk, L, Mostovoy, Y, Pashkovska, N, Pererva, L, Pertseva, T, Samoylov, O, Smirnov, I, Svyshchenko, Y, Tomashkevych, H, Topchii, I, Tryshchuk, N, Tseluyko, V, Vizir, V, Vlasenko, M, Zlova, T, Zub, L, Abusnana, S, Railey, M, Abouglila, K, Ainsworth, P, Ali, Z, Arutchelvam, V, Barnard, M, Bellary, S, Davies, E, Davies, M, Davies, S, Dawson, A, El Kossi, M, English, P, Fraser, D, Gnudi, L, Gunstone, A, Hall, T, Hanif, W, Jackson, A, Johnson, A, Joseph, F, Krishnan, S, Kumwenda, M, Macdougall, I, Nixon, P, O'Hare, J, Philip, S, Ramtoola, S, Saxena, M, Sennik, D, Simon, G, Singh, B, Stephens, J, Strzelecka, A, Symonds, R, Turner, W, Wahba, M, Wakeling, J, Wheeler, D, Winocour, P, Abdallah, J, Abdullah, R, Abramowitz, M, Acosta, I, Aiello, J, Akright, L, Akyea-Djamson, A, Alappan, R, Alicic, R, Al-Karadsheh, A, Allison, Dc, Arauz-Pacheco, C, Arfeen, S, Arif, A, Arvind, M, Atray, N, Awad, A, Barnhill, P, Barranco, E, Barrera, C, Beacom, M, Behara, V, 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Trenche, S, Narayanan, M, Narvarte, J, Nassar, T, Newman, G, Nichol, B, Nicol, P, Nisnisan, J, Nossuli, Ak, Obialo, C, Olelewe, S, Oliver, M, O'Shaughnessy, A, Padron, J, Pankhaniya, R, Parker, R, Patel, D, Patel, G, Patel, N, Pavon, H, Perez, A, Perez, C, Perlman, A, Pettis, K, Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, Zaniewski-Singh, M., Perkovic, Vlado, Jardine, Meg J, Neal, Bruce, Bompoint, Severine, Heerspink, Hiddo J L, Charytan, David M, Edwards, Robert, Agarwal, Rajiv, Bakris, George, Bull, Scott, Cannon, Christopher P, Capuano, George, Chu, Pei-Ling, de Zeeuw, Dick, Greene, Tom, Levin, Adeera, Pollock, Carol, Wheeler, David C, Yavin, Yshai, Zhang, Hong, Zinman, Bernard, Meininger, Gary, Brenner, Barry M, Mahaffey, Kenneth W, collaborator: Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M, Morren, F, Goykhman, S, David, C, Yost, L, Wang, H, Hettiarachchi, M, Thimmaiah, R, Koppolu, D, George, S, Schmidt, M, Ignjatovic, J, Chapin, L, Travis, K, Destree, M, Sood, V, Coffee, L, De Brouwer, K, Zaviriukha, V, Starzec, A, Koizumi, M, Lin, G, Chen, E, Lin, P, Leia, C, Mascaro, D, Amigo, A, Limos, A, Abrahamsen, I, Jaffer, S, Ahuad Guerrero, Ra, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Gonzalez Colaso, Pdc, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, Leon de la Fuente, Ra, Marchetta, N, Mele, P, Nicolai, S, Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Rodriguez Papini, N, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Smith Casabella, T, Ulla, Mr, Valdez, M, Vallejos, A, Villarino, A, Visco, Ve, Wassermann, A, Zaidman, Cj, Cheung, Nw, Droste, C, Fraser, I, Johnson, D, Mah, Pm, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, Ra, Alves da Costa, Fa, Amodeo, C, Andreotti Turatti, La, Bregman, R, Camelo Sanches, Fc, Canani, Lh, Chacra, Ar, Cunha Borges, Jl, Cunha Vêncio, Sa, da Silva Franco, Rj, D'Avila, D, de Souza Portes, E, de Souza, P, Deboni, Lm, Filho, Ff, Geloneze Neto, B, Gomes, M, Kohara, Sk, Keitel, E, Kerr Saraiva, Jf, Kurtz Lisboa, Hr, de Carvalho Contieri, Fl, Milagres, R, Montenegro Junior, R, Moreira de Brito, C, Nazzer Hissa, M, Nazario Sabbag, 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- Subjects
Aged ,Canagliflozin ,Cardiovascular Diseases ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Humans ,Kidney Failure, Chronic ,Male ,Middle Aged ,Sodium-Glucose Transporter 2 Inhibitors ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Diabetic nephropathy ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,030212 general & internal medicine ,03.02. Klinikai orvostan ,Dapagliflozin ,Chronic ,11 Medical and Health Sciences ,EMPAGLIFLOZIN ,General Medicine ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Nephropathy ,03 medical and health sciences ,Medicine, General & Internal ,Internal medicine ,Diabetes mellitus ,General & Internal Medicine ,CREDENCE Trial Investigators ,medicine ,Diabetes Mellitus ,Science & Technology ,business.industry ,urogenital system ,diabetic nephropathy ,Type 2 Diabetes Mellitus ,KIDNEY-DISEASE ,medicine.disease ,chemistry ,business ,Kidney disease - Abstract
BACKGROUND: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin-angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of
- Published
- 2019
50. Present state of art in high power traveling-wave tubes
- Author
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Nalos, Ervin J.
- Subjects
Traveling-wave tubes -- Research ,Microwave circuits -- Research ,Business ,Electronics and electrical industries ,Engineering and manufacturing industries ,Telecommunications industry - Abstract
The state of the art in the field of high power microwave devices, particularly in the area of linear beam circuits, as of 1959 is discussed. Interaction circuits for O and M type tubes are also described.
- Published
- 2008
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