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The identification of individuals at a higher risk of developing caries is of great interest. Isolated forms of cleft lip and palate are among the most common craniofacial congenital anomalies in humans. Historically, several reports suggest that individuals born with clefts have a higher risk for caries. Caries continues to be the most common infectious noncontagious disease worldwide and a great burden to any health system. The identification of individuals of higher susceptibility to caries is of great interest. In this paper, we assessed caries experience of 1,593 individuals from three distinct populations. The study included individuals born with clefts, their unaffected relatives, and unrelated unaffected controls that were recruited from areas with similar cultural pressures and limited access to dental care. DMFT/dmft scores were obtained, and caries experience rates were compared among the three groups in each geographic area. Individuals born with clefts did not present higher caries experience in comparison to their unaffected relatives or unrelated unaffected controls. Women tend to present higher caries rates in comparison to men. Our work provides strong evidence that individuals born with clefts are not at higher risk to caries; however, women tend to have more severe caries experience., Instituto Multidisciplinario de Biología Celular

To compare caries experience and periodontal status between two U.S. populations that lived a century apart.The University of Pittsburgh, School of Dental Medicine possesses a collection of skulls that was organised in the first half of the 20th century. Those individuals are likely to have lived in the northeast United States during the late 19th century and the early 20th century. The present study measured caries and periodontal disease morbidity in the collection of skulls and compared the data with current prevalence rates of these diseases in the United States (from the third National Health and Nutrition Examination Survey 1988-94).Periodontal health appears to have improved since this population resided, over 150 years ago. On the other hand, Americans between the ages of 16 and 39 appear to have the same prevalence of caries as a group of individuals that lived 150 years ago.The periodontal health of Americans has probably improved in the last 100 years. The individuals identified that were free of caries and periodontal disease among the group that lived during the 19th century may have some protective factor against these diseases.