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2. Systematische Untersuchung von Kombinationswirkungen der HHV-8-Gene auf die NF-κB-Aktivierung

Author

Konrad, Andreas, Wies, E., Thurau, M., Sander, G., Leubert, R., Naschberger, E., Erfle, H., Brors, B., Eils, R., Neipel, F., Hohenberger, W., Stürzl, M., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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4. Complete DNA sequence of yeast chromosome XI

Author

Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J.P.G., Banrevl, A., P.A. Bolle, Boloth-Fukuhara, M., Bossier, P., Bou, G., Boyer, J., Bultrago, M.J., Cheret, G., Colleaux, L., Dalgnan-Fronier, B., Rey, F. del, Dlon, C., Domdey, H., Dusterhoft, A., Dusterhus, S., Entian, K.-D., Erfle, H., Esteban, P.F., and Feldmann, H.

Subjects
Nucleotide sequence -- Analysis, Chromosomes -- Research, Yeast -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Determination of the complete DNA sequence of yeast chromosome XI reveals facts regarding certain unique genes. Homologues to genes that perform varied functions in multicellular organisms are used to identify the gene function or to develop new therapeutic agents. These unique genes are also involved in human pathologies such as xeroderma pigmentosum or adrenoleukodistrophy.

Published
1994

6. Genes involved in the Osteopontin pathway are involved in proliferation and migration of human aortic smooth muscle cells

Author

Keese, M, Zhang, L, and Erfle, H

Subjects
ddc: 610, cardiovascular system, 610 Medical sciences, Medicine, musculoskeletal system, tissues
Abstract

Background: In healthy normal blood vessels, vSMCs exhibit a contractile, quiescent state, in which cells have increased cytoplasmic myofilaments and are involved in maintaining the vascular tone. However, during a pathogenic vascular remodeling (i.e. after endovascular intervention), vSMCs are triggered[for full text, please go to the a.m. URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2016
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7. The Yeast Genome Directory

Author

Goffeau, A., Aert, R., Agostini-Carbone, M. L., Ahmed, A., Aigle, M., Alberghina, L., Albermann, K., Albers, M., Aldea, M., Alexandraki, D., Aljinovic, G., Allen, E., Alt-Mörbe, J., André, B., Andrews, S., Ansorge, W., Antoine, G., Anwar, R., Aparicio, A., Araujo, R., Arino, J., Arnold, F., Arroyo, J., Aviles, E., Backes, U., Baclet, M. C., Badcock, K., Bahr, A., Baladron, V., Ballesta, J. P. G., Bankier, A. T., Banrevi, A., Bargues, M., Baron, L., Barreiros, T., Barrell, B. G., Barthe, C., Barton, A. B., Baur, A., Bécam, A.-M., Becker, A., Becker, I., Beinhauer, J., Benes, V., Benit, P., Berben, G., Bergantino, E., Bergez, P., Berno, A., Bertani, I., Biteau, N., Bjourson, A. J., Blöcker, H., Blugeon, C., Bohn, C., Boles, E., Bolle, P. A., Bolotin-Fukuhara, M., Bordonné, R., Boskovic, J., Bossier, P., Botstein, D., Bou, G., Bowman, S., Boyer, J., Brandt, P., Brandt, T., Brendel, M., Brennan, T., Brinkman, R., Brown, A., Brown, A. J. P., Brown, D., Brückner, M., Bruschi, C. V., Buhler, J. M., Buitrago, M. J., Bussereau, F., Bussey, H., Camasses, A., Carcano, C., Carignani, G., Carpenter, J., Casamayor, A., Casas, C., Castagnoli, L., Cederberg, H., Cerdan, E., Chalwatzis, N., Chanet, R., Chen, E., Chéret, G., Cherry, J. M., Chillingworth, T., Christiansen, C., Chuat, J.-C., Chung, E., Churcher, C., Churcher, C. M., Clark, M. W., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Colleaux, L., Connor, R., Contreras, R., Cooper, J., Copsey, T., Coster, F., Coster, R., Couch, J., Crouzet, M., Cziepluch, C., Daignan-Fornier, B., Dal Paro, F., Dang, D. V., D’Angelo, M., Davies, C. J., Davis, K., Davis, R. W., De Antoni, A., Dear, S., Dedman, K., Defoor, E., De Haan, M., Delaveau, Th., Del Bino, S., Delgado, M., Delius, H., Delneri, D., Del Rey, F., Demolder, J., Démolis, N., Devlin, K., de Wergifosse, P., Dietrich, F. S., Ding, H., Dion, C., Dipaolo, T., Doignon, F., Doira, C., Domdey, H., Dover, J., Du, Z., Dubois, E., Dujon, B., Duncan, M., Durand, P., Düsterhöft, A., Düsterhus, S., Eki, T., El Bakkoury, M., Eide, L. G., Entian, K.-D., Eraso, P., Erdmann, D., Erfle, H., Escribano, V., Esteban, M., Fabiani, L., Fabre, F., Fairhead, C., Fartmann, B., Favello, A., Faye, G., Feldmann, H., Fernandes, L., Feroli, F., Feuermann, M., Fiedler, T., Fiers, W., Fleig, U. N., Flöth, M., Fobo, G. M., Fortin, N., Foury, F., Francingues-Gaillard, M. C., Franco, L., Fraser, A., Friesen, J.D., Fritz, C., Frontali, L., Fukuhara, H., Fulton, L., Fuller, L. J., Gabel, C., Gaillardin, C., Gaillon, L., Galibert, F., Galisson, F., Galland, P., Gamo, F.-J., Gancedo, C., Garcia-Cantalejo, J. M., García-Gonzalez, M. I., Garcia-Ramirez, J. J., García-Saéz, M., Gassenhuber, H., Gatius, M., Gattung, S., Geisel, C., Gent, M. E., Gentles, S., Ghazvini, M., Gigot, D., Gilliquet, V., Glansdorff, N., Gómez-Peris, A., Gonzaléz, A., Goulding, S. E., Granotier, C., Greco, T., Grenson, M., Grisanti, P., Grivell, L. A., Grothues, D., Gueldener, U., Guerreiro, P., Guzman, E., Haasemann, M., Habbig, B., Hagiwara, H., Hall, J., Hallsworth, K., Hamlin, N., Hand, N. J., Hanemann, V., Hani, J., Hankeln, T., Hansen, M., Harris, D., Harris, D. E., Hartzell, G., Hatat, D., Hattenhorst, U., Hawkins, J., Hebling, U., Hegemann, J., Hein, C., Hennemann, A., Hennessy, K., Herbert, C. J., Hernandez, K., Hernando, Y., Herrero, E., Heumann, K., Heuss- Neitzel, D., Hewitt, N., Hiesel, R., Hilbert, H., Hilger, F., Hillier, L., Ho, C., Hoenicka, J., Hofmann, B., Hoheisel, J., Hohmann, S., Hollenberg, C. P., Holmstrøm, K., Horaitis, O., Horsnell, T. S., Huang, M.-E., Hughes, B., Hunicke-Smith, S., Hunt, S., Hunt, S. E., Huse, K., Hyman, R. W., Iborra, F., Indge, K. J., Iraqui Houssaini, I., Isono, K., Jacq, C., Jacquet, M., Jacquier, A., Jagels, K., Jäger, W., James, C. M., Jauniaux, J. C., Jia, Y., Jier, M., Jimenez, A., Johnson, D., Johnston, L., Johnston, M., Jones, M., Jonniaux, J.-L., Kaback, D. B., Kallesøe, T., Kalman, S., Kalogeropoulos, A., Karpfinger-Hartl, L., Kashkari, D., Katsoulou, C., Kayser, A., Kelly, A., Keng, T., Keuchel, H., Kiesau, P., Kirchrath, L., Kirsten, J., Kleine, K., Kleinhans, U., Klima, R., Komp, C., Kordes, E., Korol, S., Kötter, P., Krämer, C., Kramer, B., Kreisl, P., Kucaba, T., Kuester, H., Kurdi, O., Laamanen, P., Lafuente, M. J., Landt, O., Lanfranchi, G., Langston, Y., Lashkari, D., Latreille, P., Lauquin, G., Le, T., Legrain, P., Legros, Y., Lepingle, A., Lesveque, H., Leuther, H., Lew, H., Lewis, C., Li, Z. Y., Liebl, S., Lin, A., Lin, D., Logghe, M., Lohan, A. J. E., Louis, E. J., Lucchini, G., Lutzenkirchen, K., Lyck, R., Lye, G., Maarse, A. C., Maat, M. J., Macri, C., Madania, A., Maftahi, M., Maia e Silva, A., Maillier, E., Mallet, L., Mannhaupt, G., Manus, V., Marathe, R., Marck, C., Marconi, A., Mardis, E., Martegani, E., Martin, R., Mathieu, A., Maurer, C. T. C., Mazón, M. J., Mazzoni, C., McConnell, D., McDonald, S., McKee, R. A., McReynolds, A. D. K., Melchioretto, P., Menezes, S., Messenguy, F., Mewes, H. W., Michaux, G., Miller, N., Minenkova, O., Miosga, T., Mirtipati, S., Möller-Rieker, S., Möstl, D., Molemans, F., Monnet, A., Monnier, A-L., Montague, M. A., Moro, M., Mosedale, D., Möstl, D., Moule, S., Mouser, L., Murakami, Y., Müller-Auer, S., Mulligan, J., Murphy, L., Muzi Falconi, M., Naitou, M., Nakahara, K., Namath, A., Nasr, F., Navas, L., Nawrocki, A., Nelson, J., Nentwich, U., Netter, P., Neu, R., Newlon, C. S., Nhan, M., Nicaud, J.-M., Niedenthal, R. K., Nombela, C., Noone, D., Norgren, R., Nußbaumer, B., Obermaier, B., Odell, C., Öfner, P., Oh, C., Oliver, K., Oliver, S. G., Ouellette, B. F., Ozawa, M., Paces, V., Pallier, C., Pandolfo, D., Panzeri, L., Paoluzi, S., Parle-Mcdermott, A. G., Pascolo, S., Patricio, N., Pauley, A., Paulin, L., Pearson, B. M., Pearson, D., Peluso, D., Perea, J., Pérez-Alonso, M., Pérez-Ortin, J. E., Perrin, A., Petel, F. X., Pettersson, B., Pfeiffer, F., Philippsen, P., Piérard, A., Piravandi, E., Planta, R. J., Plevani, P., Poch, O., Poetsch, B., Pohl, F. M., Pohl, T. M., Pöhlmann, R., Poirey, R., Portetelle, D., Portillo, F., Potier, S., Proft, M., Prydz, H., Pujol, A., Purnelle, B., Puzos, V., Rajandream, M. A., Ramezani Rad, M., Rasmussen, S. W., Raynal, A., Rechmann, S., Remacha, M., Revuelta, J. L., Rice, P., Richard, G-F., Richterich, P., Rieger, M., Rifken, L., Riles, L., Rinaldi, T., Rinke, M., Roberts, A. B., Roberts, D., Rodriguez, F., Rodriguez-Belmonte, E., Rodriguez-Pousada, C., Rodriguez-Torres, A. M., Rose, M., Rossau, R., Rowley, N., Rupp, T., Ruzzi, M., Saeger, W., Saiz, J. E., Saliola, M., Salom, D., Saluz, H. P., Sánchez-Perez, M., Santos, M. A., Sanz, E., Sanz, J. E., Saren, A.-M., Sartorello, F., Sasanuma, M., Sasanuma, S-I., Scarcez, T., Schaaf-Gerstenschläger, I., Schäfer, B., Schäfer, M., Scharfe, M., Scherens, B., Schroff, N., Sen-Gupta, M., Shibata, T., Schmidheini, T., Schmidt, E. R., Schneider, C., Scholler, P., Schramm, S., Schreer, A., Schröder, M., Schwager, C., Schwarz, S., Schwarzlose, C., Schweitzer, B., Schweizer, M., Sdicu, A-M., Sehl, P., Sensen, C., Sgouros, J. G., Shogren, T., Shore, L., Shu, Y., Skala, J., Skelton, J., Slonimski, P. P., Smit, P. H. M., Smith, V., Soares, H., Soeda, E., Soler-Mira, A., Sor, F., Soriano, N., Souciet, J. L., Soustelle, C., Spiegelberg, R., Stateva, L. I., Steensma, H. Y., Stegemann, J., Steiner, S., Stellyes, L., Sterky, F., Storms, R. K., St. Peter, H., Stucka, R., Taich, A., Talla, E., Tarassov, I., Tashiro, H., Taylor, P., Teodoru, C., Tettelin, H., Thierry, A., Thireos, G., Tobiasch, E., Tovan, D., Trevaskis, E., Tsuchiya, Y., Tzermia, M., Uhlen, M., Underwood, A., Unseld, M., Urbanus, J. H. M., Urrestarazu, A., Ushinsky, S., Valens, M., Valle, G., Van Broekhoven, A., Vandenbol, M., Van Der Aart, Q. J. M., Van Der Linden, C. G., Van Dyck, L., Vanoni, M., Van Vliet-Reedijk, J. C., Vassarotti, A., Vaudin, M., Vaughan, K., Verhasselt, P., Vetter, I., Vierendeels, F., Vignati, D., Vilela, C., Vissers, S., Vleck, C., Vo, D. T., Vo, D. H., Voet, M., Volckaert, G., Von Wettstein, D., Voss, H., Vreken, P., Wagner, G., Walsh, S. V., Wambutt, R., Wang, H., Wang, Y., Warmington, J. R., Waterston, R., Watson, M. D., Weber, N., Wedler, E., Wedler, H., Wei, Y., Whitehead, S., Wicksteed, B. L., Wiemann, S., Wilcox, L., Wilson, C., Wilson, R., Winant, A., Winnett, E., Winsor, B., Wipfli, P., Wölfl, S., Wohldman, P., Wolf, K., Wolfe, K. H., Wright, L. F., Wurst, H., Xu, G., Yamasaki, M., Yelton, M. A., Yokohama, K., Yoshikawa, A., Yuping, S., Zaccaria, P., Zagulski, M., Zimmermann, F. K., Zimmermann, J., Zimmermann, M., Zhong, W-W., Zollner, A., and Zumstein, E.

Published
1997
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14. Besprechungen

Author

Nachtsheim, H., Abel, O., Kallmann, H., Hillers, Wilhelm, Erfle, H., and Kniep, H.

Published
1922
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15. Study of W boson production in PbPb and pp collisions at √sNN=2.76 TeV

Author

Chatrchyan, S., Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Fabjan, C., Friedl, M., Frühwirth, R., Ghete, V. M., Hammer, J., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Knünz, V., Krammer, M., Liko, D., Mikulec, I., Pernicka, M., Rahbaran, B., Rohringer, C., Rohringer, H., Schöfbeck, R., Strauss, J., Taurok, A., Wagner, P., Waltenberger, W., Walzel, G., Widl, E., Wulz, C. E., Mossolov, V., Shumeiko, N., Suarez, Gonzalez, Bansal, J., Cornelis, S., Wolf, De, E. A., Janssen, Luyckx, X., Maes, S., Mucibello, T., Ochesanu, L., Roland, S., Rougny, B., Selvaggi, R., Staykova, M., Van, Haevermaet, Van, Mechelen, Van, Remortel, Van, Spilbeeck, Blekman, A., Blyweert, F., D'Hondt, S., Gonzalez, Suarez, Kalogeropoulos, R., Maes, A., Olbrechts, M., Van, Doninck, Van, Mulders, Van, Onsem, G. P., Villella, Charaf, I., Clerbaux, O., Lentdecker, De, Dero, G., Gay, V., A. P. R., Hreus, Léonard, T., Marage, A., P. E., Reis, Thomas, T., Vander, Velde, Vanlaer, C., Wang, P., Adler, J., Beernaert, V., Cimmino, K., Costantini, A., Garcia, S., Grunewald, G., Klein, M., Lellouch, B., Marinov, J., Mccartin, A., Ocampo, Rios, A. A., Ryckbosch, Strobbe, D., Thyssen, N., Tytgat, F., Vanelderen, M., Verwilligen, L., Walsh, P., Yazgan, S., Zaganidis, E., Basegmez, N., Bruno, S., Castello, G., Caudron, R., Ceard, A., Delaere, L., Pree, Du, Favart, T., Forthomme, D., Giammanco, L., Hollar, A., Lemaitre, J., Liao, V., Militaru, J., Nuttens, O., Pagano, C., Perrini, D., Pin, L., Piotrzkowski, A., Schul, K., Vizan, Garcia, J. M., Beliy, Caebergs, N., Daubie, T., Hammad, E., G. H., Alves, G. A., Correa Martins Junior, De Jesus Damiao, Martins, D., Pol, T., M. E., Souza, M. H. G., Aldá, Júnior, W. L., Carvalho, Custódio, W., Costa, Da, E. M., De Oliveira Martins, Fonseca De Souza, Matos, Figueiredo, Mundim, D., Nogima, L., Oguri, H., Prado Da Silva, W. L., Santoro, Soares, Jorge, Sznajder, L., Bernardes, A., C. A., Dias, F. A., Fernandez Perez Tomei, T. R., Gregores, E. M., Lagana, Marinho, C., Mercadante, F., P. G., Novaes, S. F., Padula, S. S., Genchev, Iaydjiev, V., Piperov, P., Rodozov, S., Stoykova, M., Sultanov, S., Tcholakov, G., Trayanov, V., Vutova, R., Dimitrov, M., Hadjiiska, A., Kozhuharov, R., Litov, V., Pavlov, L., Petkov, B., Bian, P., J. G., Chen, G. M., Chen, H. S., Jiang, C. H., Liang, Liang, D., Meng, S., Tao, X., Wang, J., Wang, X., Xiao, Z., Xu, H., Zang, M., Zhang, J., Asawatangtrakuldee, Z., Ban, C., Guo, Y., Guo, S., Li, Y., Liu, W., Mao, S., Qian, Y., S. J., Teng, Wang, H., Zhu, S., Zou, B., Avila, W., Gomez, C., J. P., Gomez, Moreno, Osorio, Oliveros, A. F., Sanabria, J. C., Godinovic, Lelas, N., Plestina, D., Polic, R., Puljak, D., Antunovic, I., Kovac, Z., Brigljevic, M., Duric, V., Kadija, S., Luetic, K., Morovic, J., Attikis, S., Galanti, A., Mavromanolakis, M., Mousa, G., Nicolaou, J., Ptochos, C., Razis, F., P. A., Finger, Finger, M., Assran, M., Elgammal, Y., Ellithi, Kamel, Khalil, A., Mahmoud, S., M. A., Radi, Kadastik, A., Müntel, M., Raidal, M., Rebane, M., Tiko, L., Azzolini, A., Eerola, V., Fedi, P., Voutilainen, G., Härkönen, M., Heikkinen, J., Karimäki, A., Kinnunen, V., Kortelainen, R., M. J., Lampén, Lassila, Perini, Lehti, K., Lindén, S., Luukka, T., Mäenpää, P., Peltola, T., Tuominen, T., Tuominiemi, E., Tuovinen, J., Ungaro, E., Wendland, D., Banzuzi, L., Korpela, K., Tuuva, A., Besancon, T., Choudhury, M., Dejardin, S., Denegri, M., Fabbro, D., Faure, B., J. L., Ferri, Ganjour, F., Givernaud, S., Gras, A., Hamel de Monchenault, Jarry, G., Locci, P., Malcles, E., Millischer, J., Nayak, L., Rander, A., Rosowsky, J., Shreyber, A., Titov, I., Baffioni, M., Beaudette, S., Benhabib, F., Bianchini, L., Bluj, L., Broutin, M., Busson, C., Charlot, P., Daci, C., Dahms, N., Dobrzynski, T., Granier de Cassagnac, Haguenauer, R., Miné, M., Mironov, P., Nguyen, C., Ochando, M., Paganini, C., Sabes, P., Salerno, D., Sirois, R., Veelken, Y., Zabi, C., Agram, A., J. L., Andrea, Bloch, J., Bodin, D., Brom, D., J. M., Cardaci, Chabert, M., E. C., Collard, Conte, C., Drouhin, E., Ferro, F., Fontaine, C., J. C., Gelé, Goerlach, D., Juillot, U., Karim, P., Bihan, Le, A. C., Van, Hove, Fassi, P., Mercier, F., Beauceron, D., Beaupere, S., Bondu, N., Boudoul, O., Brun, G., Chasserat, H., Chierici, J., Contardo, R., Depasse, D., Mamouni, El, Fay, H., Gascon, J., Gouzevitch, S., Ille, M., Kurca, B., Lethuillier, T., Mirabito, M., Perries, L., Sordini, S., Tosi, V., Tschudi, S., Verdier, Y., Viret, P., Tsamalaidze, S., Anagnostou, Z., Beranek, G., Edelhoff, S., Feld, M., Heracleous, L., Hindrichs, N., Jussen, O., Klein, R., Merz, K., Ostapchuk, J., Perieanu, A., Raupach, A., Sammet, F., Schael, J., Sprenger, S., Weber, D., Wittmer, H., Zhukov, B., Ata, V., Caudron, M., Dietz, Laursonn, Duchardt, E., Erdmann, D., Fischer, M., Güth, R., Hebbeker, A., Heidemann, T., Hoepfner, C., Klingebiel, K., Kreuzer, D., Lingemann, P., Magass, J., Merschmeyer, C., Meyer, M., Olschewski, A., Papacz, M., Pieta, P., Reithler, H., Schmitz, H., S. A., Sonnenschein, Steggemann, L., Teyssier, J., Bontenackels, M., Cherepanov, M., Davids, V., Flügge, M., Geenen, G., Geisler, H., Haj, Ahmad, Hoehle, W., Kargoll, F., Kress, B., Kuessel, T., Linn, Y., Nowack, A., Perchalla, A., Pooth, L., Rennefeld, O., Sauerland, J., Stahl, P., Aldaya, Martin, Behr, M., Behrenhoff, J., Behrens, W., Bergholz, U., Bethani, M., Borras, A., Burgmeier, K., Cakir, A., Calligaris, A., Campbell, L., Castro, A., Costanza, E., Dammann, F., Eckerlin, D., Eckstein, G., Fischer, D., Flucke, D., Geiser, G., Glushkov, A., Gunnellini, I., Habib, P., Hauk, S., Hellwig, J., Jung, G., Kasemann, H., Katsas, M., Kleinwort, P., Kluge, C., Knutsson, H., Krämer, A., Krücker, M., Kuznetsova, D., Lange, E., Lohmann, W., Lutz, W., Mankel, B., Marfin, R., Marienfeld, I., Melzer, Pellmann, I. A., Meyer, A. B., Mnich, Mussgiller, J., Naumann, Emme, Olzem, S., Perrey, J., Petrukhin, H., Pitzl, A., Raspereza, D., Ribeiro, Cipriano, P. M., Riedl, Rosin, C., Salfeld, Nebgen, Schmidt, J., Schoerner, Sadenius, Sen, T., Spiridonov, N., Stein, A., Walsh, M., Wissing, R., Autermann, C., Blobel, C., Bobrovskyi, V., Draeger, S., Enderle, J., Erfle, H., Gebbert, J., Görner, U., Hermanns, M., Höing, T., R. S., Kaschube, Kaussen, K., Kirschenmann, G., Klanner, H., Lange, R., Mura, J., Nowak, B., Peiffer, F., Pietsch, T., Rathjens, N., Sander, D., Schettler, C., Schleper, H., Schlieckau, P., Schmidt, E., Schröder, A., Schum, M., Seidel, T., Stadie, M., Steinbrück, H., Thomsen, G., Barth, J., Berger, C., Böser, J., Chwalek, C., Boer, De, Descroix, W., Dierlamm, A., Feindt, A., Guthoff, M., Hackstein, M., Hartmann, C., Hauth, F., Heinrich, T., Held, M., Hoffmann, H., K. H., Honc, Katkov, S., Komaragiri, I., J. R., Martschei, Mueller, D., Müller, S., Niegel, T., Nürnberg, M., Oberst, A., Oehler, O., Ott, A., Quast, J., Rabbertz, G., Ratnikov, K., Ratnikova, F., Röcker, N., Scheurer, S., Schilling, A., F. 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K., Banerjee, Bhattacharya, S., Dutta, S., Gomber, S., Jain, B., Jain, S., Khurana, S., Sarkar, R., Sharan, S., Abdulsalam, M., Choudhury, A., R. K., Dutta, Kailas, D., Kumar, S., Mehta, V., Mohanty, P., A. K., Pant, L. M., Shukla, Aziz, P., Ganguly, T., Guchait, S., Maity, M., Majumder, M., Mazumdar, G., Mohanty, K., G. B., Parida, Sudhakar, B., Wickramage, K., Banerjee, N., Dugad, S., Arfaei, S., Bakhshiansohi, H., Etesami, H., S. M., Fahim, Hashemi, A., Hesari, M., Jafari, H., Khakzad, A., Mohammadi, M., Mohammadi, Najafabadi, Paktinat, Mehdiabadi, Safarzadeh, S., Zeinali, B., Abbrescia, M., Barbone, M., Calabria, L., Chhibra, C., S. S., Colaleo, Creanzaa, A., Filippis, De, Palmaa, De, Fiore, M., Iaselli, L., Lusito, G., Maggi, L., Maggi, G., Marangelli, M., Mya, B., Nuzzo, S., Pacifico, S., Pompili, N., Pugliese, A., Selvaggi, G., Silvestris, G., Singh, L., Venditti, G., Zito, R., Abbiendi, G., Benvenuti, G., A. C., Bonacorsi, Braibant, Giacomelli, Brigliadori, S., Capiluppi, L., Castro, P., Cavallo, A., F. R., Cuffiani, Dallavalle, M., G. M., Fabbri, Fanfani, F., Fasanella, A., Giacomelli, D., Grandi, P., Guiducci, C., Marcellini, L., Masetti, S., Meneghelli, G., Montanari, M., Avarria, A., F. L., Odorici, Perrottaa, F., Primavera, A., Rossi, F., A. M., Rovelli, Siroli, T., Travaglini, G., Albergo, R., Cappello, S., Chiorboli, G., Costa, M., Potenza, S., Tricomi, R., Tuve, A., Barbagli, C., Ciulli, G., Civinini, V., D'Alessandro, C., Focardi, R., Frosali, E., Gallo, S., Gonzi, E., Meschini, S., Paoletti, M., Sguazzoni, S., Tropiano, G., Benussi, A., Bianco, L., Colafranceschi, S., Fabbri, S., Piccolo, F., Fabbricatore, D., Musenich, P., Benaglia, R., Guio, De, Matteo, Di, Fiorendi, L., Gennai, S., Ghezzi, S., Malvezzi, A., Manzoni, S., R. A., Martelli, Massironi, A., Menascea, A., Moroni, D., Paganoni, L., Pedrini, M., Ragazzi, D., Redaelli, S., Salaa, N., Tabarelli de Fatis, Buontempo, T., Carrillo, Montoya, C. A., Cavallo, Cosa, De, Dogangun, A., Fabozzi, O., Iorio, F., A. O. M., Listaa, Meola, L., Merolaa, S., Paolucci, M., Azzi, P., Bacchetta, P., Bisello, N., Branca, D., Carlin, A., Checchia, R., Dorigo, P., Dosselli, T., Gasparini, U., Gasparini, F., Gozzelino, U., Kanishchev, A., Lacaprara, K., Lazzizzera, S., Margoni, I., Meneguzzo, M., A. T., Pazzini, Perrozzi, J., Pozzobon, L., Ronchese, N., Simonetto, P., Torassa, F., Tosi, E., Vanini, M., Zotto, S., Zucchettaa, P., Zumerle, A., Gabusi, G., Ratti, M., S. P., Riccardi, Torre, C., Vitulo, P., Biasini, P., Bilei, M., G. M., Fanò, Lariccia, L., Lucaroni, P., Mantovani, A., Menichelli, G., Nappi, M., Romeo, A., Saha, F., Santocchia, A., Taroni, A., Azzurri, S., Bagliesi, P., Boccali, G., Broccolo, T., Castaldi, G., D'Agnolo, R., R. T., Dell'Orso, Fiori, R., Foà, F., Giassi, L., Kraan, A., Ligabue, A., Lomtadze, F., Martini, T., Messineo, ALBERTO MARIA, Palla, F., Rizzi, Andrea, Serban, A. T., Spagnolo, P., Squillacioti, P., Tenchini, R., Tonelli, GUIDO EMILIO, Venturi, A., Verdini, P. G., Barone, L., Cavallari, F., Del, Re, Diemoz, D., Grassi, M., Longo, M., Meridiani, E., Micheli, P., Nourbakhsh, F., Organtini, S., Paramatti, G., Rahatlou, R., Sigamani, S., Soffi, M., Amapane, L., Arcidiacono, N., Argiro, R., Arneodo, S., Biino, M., Botta, C., Cartiglia, C., Costa, N., Demaria, M., Graziano, N., Mariotti, A., Maselli, C., Migliore, S., Monaco, E., Musich, V., Obertino, M., M. M., Pastrone, Pelliccioni, N., Potenza, M., Romero, A., Ruspa, A., Sacchi, M., Sola, R., Solano, V., Staiano, A., Vilela, Pereira, Belforte, A., Cossutti, S., Della, Ricca, Gobbo, G., Marone, B., Montanino, M., Penzoa, D., Schizzi, A., Heo, A., S. G., Kim, T. Y., Nam, S. K., Chang, Chung, S., Kim, J., D. H., Kim, G. N., Kong, D. 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A., Shoaib, Brona, M., Bunkowski, G., Cwiok, K., Dominik, M., Doroba, W., Kalinowski, K., Konecki, A., Krolikowski, M., Bialkowska, J., Boimska, H., Frueboes, B., Gokieli, T., Górski, R., Kazana, M., Nawrocki, M., Romanowska, Rybinska, Szleper, K., Wrochna, M., Zalewski, G., Almeida, P., Bargassa, N., David, P., Faccioli, A., Fernandes, P., Ferreira, Parracho, P. G., Gallinaro, Seixas, M., Varela, J., Vischia, J., Afanasiev, P., Belotelov, S., Bunin, I., Gavrilenko, P., Golutvin, M., Kamenev, I., Karjavin, A., Kozlov, V., Lanev, G., Malakhov, A., Moisenz, A., Palichik, P., Perelygin, V., Shmatov, V., Smirnov, S., Volodko, V., Zarubin, A., Evstyukhin, A., Golovtsov, S., Ivanov, V., Kim, Y., Levchenko, V., Murzin, P., Oreshkin, V., Smirnov, V., Sulimov, I., Uvarov, V., Vavilov, L., Vorobyev, S., Vorobyev, A., Andreev, A., Dermenev, Y., Gninenko, A., Golubev, S., Kirsanov, N., Krasnikov, M., Matveev, N., Pashenkov, V., Tlisov, A., Toropin, D., Epshteyn, A., Erofeeva, V., Gavrilov, M., Kossov, V., Lychkovskaya, M., Popov, N., Safronov, V., Semenov, G., Stolin, S., Vlasov, V., Zhokin, E., Belyaev, A., Boos, A., Ershov, E., Gribushin, A., Klyukhin, A., Kodolova, V., Korotkikh, O., Lokhtin, V., Markina, I., Obraztsov, A., Perfilov, S., Petrushanko, M., Popov, S., Sarycheva, A., Savrin, L., Snigirev, V., Vardanyan, A., Andreev, I., Azarkin, V., Dremin, M., Kirakosyan, I., Leonidov, M., Mesyats, A., Rusakov, G., S. V., Vinogradov, Azhgirey, A., Bayshev, I., Bitioukov, I., Grishin, S., Kachanov, V., Konstantinov, V., Korablev, D., Krychkine, A., Petrov, V., Ryutin, V., Sobol, R., Tourtchanovitch, A., Troshin, L., Tyurin, S., Uzunian, N., Volkov, A., Adzic, A., Djordjevic, P., Ekmedzic, M., Krpic, M., Milosevic, D., Aguilar, Benitez, Alcaraz, Maestre, Arce, J., Battilana, P., Calvo, C., Cerrada, E., Chamizo, Llatas, Colino, M., De La Cruz, Delgado, Peris, Diez, Pardos, Domínguez, Vázquez, Fernandez, Bedoya, Fernández, Ramos, J. P., Ferrando, Flix, A., Fouz, J., M. C., Garcia, Abia, Gonzalez, Lopez, Goy, Lopez, Hernandez, S., J. M., Josa, M. I., Merino, Puerta, Pelayo, Quintario, Olmeda, Redondo, A., Romero, I., Santaolalla, L., Soares, J., M. S., Willmott, Albajar, C., Codispoti, C., Trocóniz, De, J. F., Cuevas, Fernandez, Menendez, Folgueras, J., Gonzalez, Caballero, Lloret, Iglesias, Piedra, Gomez, Brochero, Cifuentes, J. A., Cabrillo, I. J., Calderon, Chuang, A., S. H., Duarte, Campderros, Felcini, J., Fernandez, M., Gomez, M., Gonzalez, Sanchez, Jorda, J., Lobelle, Pardo, Lopez, Virto, Marco, A., Marco, J., Martinez, Rivero, Matorras, C., Munoz, Sanchez, F. J., Rodrigo, Rodríguez, Marrero, A. Y., Ruiz, Jimeno, Scodellaro, A., Sobron, Sanudo, Vila, M., Vilar, Cortabitarte, Abbaneo, R., Auffray, D., Auzinger, E., Baillon, G., Ball, P., A. H., Barney, Bernet, D., Bianchi, C., Bloch, G., Bocci, P., Bonato, A., Breuker, A., Camporesi, H., Cerminara, T., Christiansen, G., Coarasa, Perez, J. A., D'Enterria, Dabrowski, D., Roeck, De, Guida, Di, Dobson, S., Dupont, Sagorin, Elliott, Peisert, Frisch, A., Funk, B., Georgiou, W., Giffels, G., Gigi, M., Gill, D., Giordano, K., Giunta, D., Glege, M., Gomez Reino Garrido, Govoni, R., Gowdy, P., Guida, S., Hansen, R., Harris, M., Hartl, P., Harvey, C., Hegner, J., Hinzmann, B., Innocente, A., Janot, V., Kaadze, P., Karavakis, K., Kousouris, E., Lecoq, K., Lee, P., Y. J., Lenzi, Lourenço, P., Mäki, C., Malberti, T., Malgeri, M., Mannelli, L., Masetti, M., Meijers, L., Mersi, F., Meschi, S., Moser, E., Mozer, R., M. U., Mulders, Musella, M., Nesvold, P., Orimoto, E., Orsini, T., Palencia, Cortezon, Perez, E., Petrilli, E., Pfeiffer, A., Pierini, A., Pimiä, M., Piparo, M., Polese, D., Quertenmont, G., Racz, L., Reece, A., Rodrigues, Antunes, Rolandi, J., Rommerskirchen, G., Rovelli, T., Rovere, C., Sakulin, M., Santanastasio, H., Schäfer, F., Schwick, C., Segoni, C., Sekmen, I., Sharma, S., Siegrist, A., Silva, P., Simon, P., Sphicas, M., Spiga, P., Spiropulu, D., Stoye, M., Tsirou, M., Veres, A., G. I., Vlimant, J. R., Wöhri, H. K., Worm, S. D., Zeuner, W. D., Bertl, Deiters, W., Erdmann, K., Gabathuler, W., Horisberger, K., Ingram, R., Kaestli, Q., H. C., König, Kotlinski, S., Langenegger, D., Meier, U., Renker, F., Rohe, D., Sibille, T., Bäni, J., Bortignon, L., Buchmann, P., M. 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W., Olaiya, Petyt, E., Radburn, Smith, B. C., Shepherd, Themistocleous, C. H., Tomalin, I. R., Womersley, W. J., Bainbridge, Ball, R., Beuselinck, G., Buchmuller, R., Colling, O., Cripps, D., Cutajar, N., Dauncey, M., Davies, P., Della, Negra, Ferguson, M., Fulcher, W., Futyan, J., Gilbert, D., Guneratne, Bryer, Hall, A., Hatherell, G., Hays, Z., Iles, J., Jarvis, G., Karapostoli, M., Lyons, G., Magnan, L., A. M., Marrouche, Mathias, J., Nandi, B., Nash, R., Nikitenko, J., Papageorgiou, A., Pela, A., Pesaresi, J., Petridis, M., Pioppi, K., Raymond, M., D. M., Rogerson, Rose, S., Ryan, A., M. J., Seez, Sharp, C., Sparrow, P., Tapper, A., Vazquez, Acosta, Virdee, M., Wakefield, T., Wardle, S., Whyntie, N., Chadwick, T., Cole, M., J. E., Hobson, P. R., Khan, Kyberd, A., Leggat, P., Leslie, D., Martin, D., Reid, W., I. D., Symonds, Teodorescu, P., Turner, L., Hatakeyama, M., Liu, K., Scarborough, H., Henderson, T., Rumerio, C., Avetisyan, P., Bose, A., Fantasia, T., Heister, C., John, A., S. J., Lawson, Lazic, P., Rohlf, D., Sperka, J., Sulak, D., Alimena, L., Bhattacharya, J., Cutts, S., Ferapontov, D., Heintz, A., Jabeen, U., Kukartsev, S., Laird, G., Landsberg, E., Luk, G., Narain, M., Nguyen, M., Segala, D., Sinthuprasith, M., Speer, T., Tsang, T., K. V., Breedon, Breto, R., Calderon De La Barca Sanchez, Chauhan, M., Chertok, S., Conway, M., Conway, J., Cox, R., P. 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W., Libeiro, Roh, T., Volobouev, Y., Appelt, I., Engh, E., Florez, D., Greene, C., Gurrola, S., Johns, A., Johnston, W., Kurt, C., Maguire, P., Melo, C., Sheldon, A., Snook, P., Tuo, B., Velkovska, S., Arenton, J., M. W., Balazs, Boutle, M., Cox, S., Francis, B., Goodell, B., Hirosky, J., Ledovskoy, R., Lin, A., Neu, C., Wood, C., Yohay, J., Gollapinni, R., Harr, S., Karchin, R., P. E., Kottachchi Kankanamge Don, Lamichhane, C., Sakharov, P., Anderson, A., Bachtis, M., Belknap, M., Borrello, D., Carlsmith, L., Cepeda, D., Dasu, M., Gray, S., Grogg, L., K. S., Grothe, Hall, Wilton, Herndon, R., Hervé, M., Klabbers, A., Klukas, P., Lanaro, J., Lazaridis, A., Leonard, C., Loveless, J., Mohapatra, R., Ojalvo, A., Palmonari, I., Pierro, F., G. A., Ross, Savin, I., Smith, A., W. H., Swanson, Guo S, J., Guo, Y, Li, W, Mao, Y, Qian, Sj, Teng, H, Zhang, L, Zhu, B, Zou, W, Cabrera, A, Moreno, Bg, Rios, Aao, Oliveros, Afo, Sanabria, Jc, Godinovic, N, Lelas, D, Lelas, K, Plestina, R, Polic, D, Puljak, I, Antunovic, Z, Dzelalija, M, Brigljevic, V, Duric, S, Kadija, K, Morovic, S, Attikis, A, Galanti, M, Mousa, J, Nicolaou, C, Ptochos, F, Razis, Pa, Rykaczewski, H, Assran, Y, Mahmoud, Ma, Hektor, A, Kadastik, M, Kannike, K, Muentel, M, Raidal, M, Rebane, L, Azzolini, V, Eerola, P, Czellar, S, Harkonen, J, Heikkinen, A, Karimaki, V, Kinnunen, R, Klem, J, Kortelainen, Mj, Lampen, T, Lassila Perini, K, Lehti, S, Linden, T, Luukka, P, Maenpaa, T, Tuominen, E, Tuominiemi, J, Tuovinen, E, Ungaro, D, Wendland, L, Banzuzi, K, Korpela, A, Tuuva, T, Sillou, D, Besancon, M, Choudhury, S, Dejardin, M, Denegri, D, Fabbro, B, Faure, Jl, Ferri, F, Ganjour, S, Gentit, Fx, Givernaud, A, Gras, P, de Monchenault GH, Jarry, P, Locci, E, Malcles, J, Marionneau, M, Millischer, L, Rander, J, Rosowsky, A, Shreyber, I, Titov, M, Verrecchia, P, Baffioni, S, Beaudette, F, Bianchini, L, Bluj, M, Broutin, C, Busson, P, Charlot, C, Dahms, T, Dobrzynski, L, de Cassagnac RG, Haguenauer, M, Mine, P, Mironov, C, Ochando, C, Paganini, P, Sabes, D, Salerno, R, Sirois, Y, Thiebaux, C, Wyslouch, B, Zabi, A, Agram, Jl, Andrea, J, Besson, A, Bloch, D, Bodin, D, Brom, Jm, Cardaci, M, Chabert, Ec, Collard, C, Conte, E, Drouhin, F, Ferro, C, Fontaine, Jc, Gele, D, Goerlach, U, Greder, S, Juillot, P, Karim, M, Le Bihan AC, Mikami, Y, Van Hove, P, Fassi, F, Mercier, D, Baty, C, Beaupere, N, Bedjidian, M, Bondu, O, Boudoul, G, Boumediene, D, Brun, H, Chanon, N, Chierici, R, Contardo, D, Depasse, P, El Mamouni, H, Falkiewicz, A, Fay, J, Gascon, S, Ille, B, Kurca, T, Le Grand, T, Lethuillier, M, Mirabito, L, Perries, S, Sordini, V, Tosi, S, Tschudi, Y, Verdier, P, Xiao, H, Roinishvili, V, Lomidze, D, Anagnostou, G, Edelhoff, M, Feld, L, Heracleous, N, Hindrichs, O, Jussen, R, Klein, K, Merz, J, Mohr, N, Ostapchuk, A, Perieanu, A, Raupach, F, Sammet, J, Schael, S, Sprenger, D, Weber, H, Weber, M, Wittmer, B, Ata, M, Bender, W, Erdmann, M, Frangenheim, J, Hebbeker, T, Hinzmann, A, Hoepfner, K, Hof, C, Klimkovich, T, Klingebiel, D, Kreuzer, P, Lanske, D, Magass, C, Masetti, G, Merschmeyer, M, Meyer, A, Papacz, P, Pieta, H, Reithler, H, Schmitz, Sa, Sonnenschein, L, Steggemann, J, Teyssier, D, Bontenackels, M, Davids, M, Duda, M, Flugge, G, Geenen, H, Giffels, M, Ahmad, Wh, Heydhausen, D, Kress, T, Kuessel, Y, Linn, A, Nowack, A, Perchalla, L, Pooth, O, Rennefeld, J, Sauerland, P, Stahl, A, Thomas, M, Tornier, D, Zoeller, Mh, Martin, Ma, Behrenhoff, W, Behrens, U, Bergholz, M, Borras, K, Cakir, A, Campbell, A, Castro, E, Dammann, D, Eckerlin, G, Eckstein, D, Flossdorf, A, Flucke, G, Geiser, A, Glushkov, I, Hauk, J, Jung, H, Kasemann, M, Katkov, I, Katsas, P, Kleinwort, C, Kluge, H, Knutsson, A, Krucker, D, Kuznetsova, E, Lange, W, Lohmann, W, Mankel, R, Marienfeld, M, Melzer Pellmann IA, Meyer, Ab, Mnich, J, Mussgiller, A, Olzem, J, Parenti, A, Raspereza, A, Raval, A, Schmidt, R, Schoerner Sadenius, T, Sen, N, Stein, M, Tomaszewska, J, Volyanskyy, D, Walsh, R, Wissing, C, Autermann, C, Bobrovskyi, S, Draeger, J, Enderle, H, Gebbert, U, Kaschube, K, Kaussen, G, Klanner, R, Lange, J, Mura, B, Naumann Emme, S, Nowak, F, Pietsch, N, Sander, C, Schettler, H, Schleper, P, Schroder, M, Schum, T, Schwandt, J, Srivastava, Ak, Stadie, H, Steinbruck, G, Thomsen, J, Wolf, R, Barth, C, Bauer, J, Buege, V, Chwalek, T, De Boer, W, Dierlamm, A, Dirkes, G, Feindt, M, and Gruschke, J.

Subjects
Heavy-ions, Nuclear and High Energy Physics, Heavy Ion collision, CMS experiment, ROOT-S=7 TEV, Physics::Instrumentation and Detectors, CMS, Physics, ATLAS DETECTOR, W bosons, HEAVY-ION COLLISIONS, PRODUCTION CROSS-SECTION, Physics and Astronomy, High Energy Physics::Experiment, LHC, Nuclear Experiment
Abstract

A measurement is presented of W-boson production in PbPb collisions carried out at a nucleon-nucleon (NN) centre-of-mass energy root S-NN of 2.76 TeV at the LHC using the CMS detector. In data corresponding to an integrated luminosity of 7.3 mu b(-1), the number of W -> mu v(mu) decays is extracted in the region of muon pseudorapidity vertical bar eta mu vertical bar < 2.1 and transverse momentum p(T)(mu) > 25 GeV/c. Yields of muons found per unit of pseudorapidity correspond to (159 +/- 10(stat.) +/- 12(syst.)) x 10(-8) W and (154 +/- 10(stat.) +/- 12(syst.)) x 10(-8) W- bosons per minimum-bias PbPb collision. The dependence of W production on the centrality of PbPb collisions is consistent with a scaling of the yield by the number of incoherent NN collisions. The yield of W bosons is also studied in a sample of pp interactions at root S = 2.76 TeV corresponding to an integrated luminosity of 231 nb(-1). The individual W+ and W- yields in PbPb and pp collisions are found to agree, once the neutron and proton content in Pb nuclei is taken into account. Likewise, the difference observed in the dependence of the positive and negative muon production on pseudorapidity is consistent with next-to-leading-order perturbative QCD calculations.

Published
2012

19. Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice

Author

Vinnikov, I. A., primary, Hajdukiewicz, K., additional, Reymann, J., additional, Beneke, J., additional, Czajkowski, R., additional, Roth, L. C., additional, Novak, M., additional, Roller, A., additional, Dorner, N., additional, Starkuviene, V., additional, Theis, F. J., additional, Erfle, H., additional, Schutz, G., additional, Grinevich, V., additional, and Konopka, W., additional

Published
2014
Full Text
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20. Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases.

Author

Ritzerfeld, J., Remmele, S., Wang, T., Temmerman, K., Brugger, B., Wegehingel, S., Tournaviti, S., Strating, J.R.P.M., Wieland, F.T., Neumann, B., Ellenberg, J., Lawerenz, C., Hesser, J., Erfle, H., Pepperkok, R., Nickel, W., Ritzerfeld, J., Remmele, S., Wang, T., Temmerman, K., Brugger, B., Wegehingel, S., Tournaviti, S., Strating, J.R.P.M., Wieland, F.T., Neumann, B., Ellenberg, J., Lawerenz, C., Hesser, J., Erfle, H., Pepperkok, R., and Nickel, W.

Abstract

01 november 2011, Contains fulltext : 97222.pdf (publisher's version ) (Open Access), SRC proteins are non-receptor tyrosine kinases that play key roles in regulating signal transduction by a diverse set of cell surface receptors. They contain N-terminal SH4 domains that are modified by fatty acylation and are functioning as membrane anchors. Acylated SH4 domains are both necessary and sufficient to mediate specific targeting of SRC kinases to the inner leaflet of plasma membranes. Intracellular transport of SRC kinases to the plasma membrane depends on microdomains into which SRC kinases partition upon palmitoylation. In the present study, we established a live-cell imaging screening system to identify gene products involved in plasma membrane targeting of SRC kinases. Based on siRNA arrays and a human model cell line expressing two kinds of SH4 reporter molecules, we conducted a genome-wide analysis of SH4-dependent protein targeting using an automated microscopy platform. We identified and validated 54 gene products whose down-regulation causes intracellular retention of SH4 reporter molecules. To detect and quantify this phenotype, we developed a software-based image analysis tool. Among the identified gene products, we found factors involved in lipid metabolism, intracellular transport, and cellular signaling processes. Furthermore, we identified proteins that are either associated with SRC kinases or are related to various known functions of SRC kinases such as other kinases and phosphatases potentially involved in SRC-mediated signal transduction. Finally, we identified gene products whose function is less defined or entirely unknown. Our findings provide a major resource for future studies unraveling the molecular mechanisms that underlie proper targeting of SRC kinases to the inner leaflet of plasma membranes.

Published
2011

21. Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases

Author

Ritzerfeld, J., primary, Remmele, S., additional, Wang, T., additional, Temmerman, K., additional, Brugger, B., additional, Wegehingel, S., additional, Tournaviti, S., additional, Strating, J. R. P. M., additional, Wieland, F. T., additional, Neumann, B., additional, Ellenberg, J., additional, Lawerenz, C., additional, Hesser, J., additional, Erfle, H., additional, Pepperkok, R., additional, and Nickel, W., additional

Published
2011
Full Text
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42. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana

Author

Salanoubat, M., Lemcke, K., Rieger, M., Ansorge, W., Unseld, M., Fartmann, B., Valle, G., Blocker, H., Perez-Alonso, M., Obermaier, B., Delseny, M., Boutry, M., Grivell, La, Mache, R., Puigdomenech, P., Simone, V., Choisne, N., Artiguenave, F., Robert, C., Brottier, P., Wincker, P., Cattolico, L., Weissenbach, J., Saurin, W., Quetier, F., Schafer, M., Muller-Auer, S., Gabel, C., Fuchs, M., Benes, V., Wurmbach, E., Drzonek, H., Erfle, H., Jordan, N., Bangert, S., Wiedelmann, R., Kranz, H., Voss, H., Holland, R., Brandt, P., Nyakatura, G., Vezzi, A., D Angelo, M., Alberto Pallavicini, Toppo, S., Simionati, B., Conrad, A., Hornischer, K., Kauer, G., Lohnert, Th, Nordsiek, G., Reichelt, J., Scharfe, M., Schon, O., Bargues, M., Terol, J., Climent, J., Navarro, P., Collado, C., Perez-Perez, A., Ottenwalder, B., Duchemin, D., Cooke, R., Laudie, M., Berger-Llauro, C., Purnelle, B., Masuy, D., Haan, M., Maarse, Ac, Alcaraz, Jp, Cottet, A., Casacuberta, E., Monfort, A., Argiriou, A., Flores, M., Liguori, R., Vitale, D., Mannhaupt, G., Haase, D., Schoof, H., Rudd, S., Zaccaria, P., Mewes, Hw, Mayer, Kfx, Kaul, S., Town, Cd, Koo, Hl, Tallon, Lj, Jenkins, J., Rooney, T., Rizzo, M., Walts, A., Utterback, T., Fujii, Cy, Shea, Tp, Creasy, Th, Haas, B., Maiti, R., Wu, Dy, Peterson, J., Aken, S., Pai, G., Militscher, J., Sellers, P., Gill, Je, Feldblyum, Tv, Preuss, D., Lin, Xy, Nierman, Wc, Salzberg, Sl, White, O., Venter, Jc, Fraser, Cm, Kaneko, T., Nakamura, Y., Sato, S., Kato, T., Asamizu, E., Sasamoto, S., Kimura, T., Idesawa, K., Kawashima, K., Kishida, Y., Kiyokawa, C., Kohara, M., Matsumoto, M., Matsuno, A., Muraki, A., Nakayama, S., Nakazaki, N., Shinpo, S., Takeuchi, C., Wada, T., Watanabe, A., Yamada, M., Yasuda, M., Tabata, S., European Union Chromosome 3 Arabid, Inst Genomic Res, and Dna, Kazusa Res Inst

43. Automated low-redundancy large-scale DNA sequencing by primer walking

Author

Voss, H., Stefan Wiemann, Grothues, D., Sensen, C., Zimmermann, J., Schwager, C., Stegemann, J., Erfle, H., Rupp, T., and Ansorge, W.

Subjects
Chromosome Walking, Autoanalysis, Deoxyadenine Nucleotides, Genes, Fungal, Fluorescein, DNA-Directed DNA Polymerase, Saccharomyces cerevisiae, Sequence Analysis, DNA, Cosmids, Fluoresceins, DNA Primers, Plasmids
Abstract

Low-redundancy automated DNA sequencing by primer walking is described. T7 DNA polymerase is used together with computer-selected walking primers and fluorescein-dATP as internal label to sequence large plasmids or cosmids directly on a standard DNA sequencer with an error rate below 1% up to 500 bases (in the unedited raw data). The low error rate allows efficient sequencing with low (2-3 times) redundancy. Plasmid subclones covering 20 kb of a cosmid insert were sequenced with an overall redundancy of 2.7 in the course of the European community Saccharomyces cerevisiae genome sequencing project. Neighboring plasmid subclones were linked by direct cosmid sequencing. Sets of ten walking primers are synthesized on the EMBL multiple segmental DNA synthesizer at low costs and used for sequencing with greater than 95% efficiency. The accuracy of the directed approach is improved by simultaneous walking on both strands by designing two primers in opposite directions in the same starting region. One primer is used to confirm sequence data on the opposite strand, and the other primer to obtain new sequence data.

50. Normalizing for individual cell population context in the analysis of high-content cellular screens

Author

Knapp Bettina, Rebhan Ilka, Kumar Anil, Matula Petr, Kiani Narsis A, Binder Marco, Erfle Holger, Rohr Karl, Eils Roland, Bartenschlager Ralf, and Kaderali Lars

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background High-content, high-throughput RNA interference (RNAi) offers unprecedented possibilities to elucidate gene function and involvement in biological processes. Microscopy based screening allows phenotypic observations at the level of individual cells. It was recently shown that a cell's population context significantly influences results. However, standard analysis methods for cellular screens do not currently take individual cell data into account unless this is important for the phenotype of interest, i.e. when studying cell morphology. Results We present a method that normalizes and statistically scores microscopy based RNAi screens, exploiting individual cell information of hundreds of cells per knockdown. Each cell's individual population context is employed in normalization. We present results on two infection screens for hepatitis C and dengue virus, both showing considerable effects on observed phenotypes due to population context. In addition, we show on a non-virus screen that these effects can be found also in RNAi data in the absence of any virus. Using our approach to normalize against these effects we achieve improved performance in comparison to an analysis without this normalization and hit scoring strategy. Furthermore, our approach results in the identification of considerably more significantly enriched pathways in hepatitis C virus replication than using a standard analysis approach. Conclusions Using a cell-based analysis and normalization for population context, we achieve improved sensitivity and specificity not only on a individual protein level, but especially also on a pathway level. This leads to the identification of new host dependency factors of the hepatitis C and dengue viruses and higher reproducibility of results.

Published
2011
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