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Your search keyword '"Epidioxysterol"' showing total 6 results
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6 results on '"Epidioxysterol"'

1. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli

Author

Ping-Jyun Sung, Zhi-Hong Wen, Chan-Shing Lin, Yung-Husan Chen, Jyh-Horng Sheu, Yu-Chia Chang, Yu-Hsin Chen, Yin-Di Su, Jui-Hsin Su, Chang-Feng Dai, Mei-Chin Lu, Ching-Hsiao Cheng, Wei-Hsuan Yen, and Wu-Fu Chen

Subjects
Sinularia, epidioxysterol, cytotoxicity, Organic chemistry, QD241-441
Abstract

A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1–3 towards various tumor cells is reported.

Published
2013
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2. A new 5α,8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral Sinularia sp

Author

Yue-Wei Guo, Heng Li, Wei Tang, Lin-Fu Liang, and Min Yang

Subjects
South china, biology, 010405 organic chemistry, Chemistry, Lymphocyte, Coral, Organic Chemistry, Epidioxysterol, Plant Science, biology.organism_classification, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, Microbiology, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Ic50 values, medicine, Bioassay, Sinularia, Cytotoxicity
Abstract

A new 5α,8α-epidioxysterol, namely yalongsterol A (1), along with two known related steroids 5α,8α-epidioxy-24-methyl-cholesta-6,24(28)-dien-3β-ol (2) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (3), were isolated from the South China Sea soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses and comparisons of the spectral data with those reported in the literature. In bioassay, compounds 1-3 showed moderate immunosuppressive activities against T and/or B lymphocyte cells with IC50 values ranging from 19.30 to 59.49 μM, and low cytotoxicity on murine splenocytes with CC50 values ranging from 40.88 to 62.29 μM.[Formula: see text].

Published
2019

3. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli.

Author

Wei-Hsuan Yen, Wu-Fu Chen, Ching-Hsiao Cheng, Chang-Feng Dai, Mei-Chin Lu, Jui-Hsin Su, Yin-Di Su, Yu-Hsin Chen, Yu-Chia Chang, Yung-Husan Chen, Jyh-Horng Sheu, Chan-Shing Lin, Zhi-Hong Wen, and Ping-Jyun Sung

Subjects
*STEROLS, *ALCYONACEA, *METHYLENE group, *SPECTROSCOPIC imaging, *ANTINEOPLASTIC antibiotics
Abstract

A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest- 6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1-3 towards various tumor cells is reported. [ABSTRACT FROM AUTHOR]

Published
2013
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4. 5α,8α-Epidioxysterol from the marine sponge Biemna triraphis Topsent

Author

Isabelle Bombardaa, Jean Vacelet, Julia Bensemhouna, Maurice Aknin, Emile M. Gaydou, Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion (UR), Centre d'océanologie de Marseille (COM), Université de la Méditerranée - Aix-Marseille 2-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), and Univ, Réunion

Subjects
Pharmacology, biology, 010405 organic chemistry, Zoology, Epidioxysterol, Plant Science, General Medicine, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Sponge, Triraphis, Complementary and alternative medicine, Genus, Drug Discovery, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, 14. Life underwater, West coast
Abstract

International audience; 5α,8α-Epidioxy-24(S)-ethylcholest-6-en-3β-ol was isolated from the marine sponge Biemna triraphis Topsent collected at Andavadoaka, near Toliary (west coast of Madagascar-Indian Ocean). The structure was elucidated from NMR spectroscopic data. This is the first report of this compd. in a marine sponge belonging to the Biemna genus. [on SciFinder(R)]

Published
2008

5. 5α,8α-Epidioxysterol Sulfate from a Diatom Odontella aurita

Author

Masami Ishibashi and Kazufumi Toume

Subjects
biology, Epidioxysterol, Plant Science, General Medicine, Horticulture, biology.organism_classification, Biochemistry, chemistry.chemical_compound, Diatom, Algae, chemistry, Botany, Sulfate, Molecular Biology, Odontella aurita
Abstract

A 5α,8α-epidioxysterol sulfate was isolated from the cultured diatom Odontella aurita (NIES 589), and its structure was elucidated by spectroscopic methods.

Published
2003

6. New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa

Author

Makoto Iwashima, Takao Yamori, Kazuo Iguchi, and Ikuo Terada

Subjects
Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, medicine.medical_treatment, Growth inhibitory, Antineoplastic Agents, Alkenes, Catalysis, Mass Spectrometry, Steroid, Terpene, Lethal Dose 50, Japan, Genus, Ergosterol, Drug Discovery, Chemical conversion, medicine, Animals, Humans, biology, Chemistry, Epidioxysterol, Biological activity, General Chemistry, General Medicine, biology.organism_classification, Porifera, Sponge, Cell culture, Steroids, Hydrogenation, Artemia, Drug Screening Assays, Antitumor, Oxidation-Reduction, Sesquiterpenes, Human cancer
Abstract

A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.

Published
2002

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