30 results on '"Enrique Almanza-Aguilera"'
Search Results
2. Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study
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Enrique Almanza-Aguilera, Daniel Guiñón-Fort, Aurora Perez-Cornago, Miriam Martínez-Huélamo, Cristina Andrés-Lacueva, Anne Tjønneland, Anne Kirstine Eriksen, Verena Katzke, Rashmita Bajracharya, Matthias B. Schulze, Giovanna Masala, Andreina Oliverio, Rosario Tumino, Luca Manfredi, Cristina Lasheras, Marta Crous-Bou, Maria-José Sánchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Emily Sonestedt, Anders Bjartell, Elin Thysell, Elisabete Weiderpass, Dagfinn Aune, Elom K. Aglago, Ruth C. Travis, and Raul Zamora-Ros
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polyphenols ,diet ,intake ,prostate cancer ,cohort ,EPIC ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.
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- 2023
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3. Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population
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Enrique Almanza-Aguilera, Estefanía Davila-Cordova, Daniel Guiñón-Fort, Marta Farràs, Giovanna Masala, Maria Santucci de Magistris, Ivan Baldassari, Rosario Tumino, Lisa Padroni, Verena A Katzke, Matthias B. Schulze, Augustin Scalbert, and Raul Zamora-Ros
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tyrosol ,hydroxytyrosol ,urine ,olive oil ,wine ,biomarkers ,Therapeutics. Pharmacology ,RM1-950 - Abstract
This study analyzed the correlations between the acute and habitual intake of dietary tyrosols, their main food sources, and 24 h urine excretions of tyrosol (Tyr) and hydroxytyrosol (OHTyr) in participants from the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (n = 419) were healthy men and women aged from 34 to 73 years from 8 EPIC centers belonging to France, Italy, and Germany. Acute and habitual dietary data were collected using a standardized 24 h dietary recall software and validated country-specific dietary questionnaires, respectively. The intake of 13 dietary tyrosols was estimated using the Phenol-Explorer database. Excretions of Tyr and OHTyr in a single 24 h urine sample were analyzed using tandem mass spectrometry. Urinary excretions of Tyr, OHTyr, and their sum (Tyr + OHTyr) correlated more strongly with their corresponding acute (rhopartial~0.63) rather than habitual intakes (rhopartial~0.47). In addition, individual and combined urinary excretions of Tyr and OHTyr were weakly to moderately correlated with the acute and habitual intake of other individual tyrosol precursors (rhopartial = 0.10–0.44) and especially with major food sources, such as wine (rhopartial = 0.41–0.58), olive oil (rhopartial = 0.25–0.44), and beer (rhopartial = 0.14–0.23). Urinary Tyr + OHTyr excretions were similarly correlated with the acute intake of total tyrosols but differently correlated with food sources among countries. Based on these results, we conclude that 24 h urinary excretions of Tyr + OHTyr could be proposed as biomarkers of total tyrosol intake, preferably for acute intakes.
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- 2023
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4. Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
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Mercedes Gil-Lespinard, Jazmín Castañeda, Enrique Almanza-Aguilera, Jesús Humberto Gómez, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Cristina Lasheras, Esther Molina-Montes, José María Huerta, Aurelio Barricarte, Pilar Amiano, Emily Sonestedt, Marisa da Silva, Ingegerd Johansson, Johan Hultdin, Anne M. May, Nita G. Forouhi, Alicia K. Heath, Heinz Freisling, Elisabete Weiderpass, Augustin Scalbert, and Raul Zamora-Ros
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polyphenol ,intake ,body weight ,obesity ,cohort ,EPIC ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
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- 2022
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5. Biomarkers of food intake for cocoa and liquorice (products): a systematic review
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Charlotte C. J. R. Michielsen, Enrique Almanza-Aguilera, Elske M. Brouwer-Brolsma, Mireia Urpi-Sarda, and Lydia A. Afman
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Licorice ,Liquorice ,Cocoa ,Cacao ,Chocolate ,Metabolites ,Nutrition. Foods and food supply ,TX341-641 ,Genetics ,QH426-470 - Abstract
Abstract Background To unravel true links between diet and health, it is important that dietary exposure is accurately measured. Currently, mainly self-reporting methods (e.g. food frequency questionnaires and 24-h recalls) are used to assess food intake in epidemiological studies. However, these traditional instruments are subjective measures and contain well-known biases. Especially, estimating the intake of the group of confectionary products, such as products containing cocoa and liquorice, remains a challenge. The use biomarkers of food intake (BFIs) may provide a more objective measurement. However, an overview of current candidate biomarkers and their validity is missing for both cocoa- and liquorice-containing foods. Objective The purpose of the current study was to (1) identify currently described candidate BFIs for cocoa (products) and liquorice, (2) to evaluate the validity of these identified candidate BFIs and (3) to address further validation and/or identification work to be done. Methods This systematic review was based on a comprehensive literature search of three databases (PubMed, Scopus and ISI web of Science), to identify candidate BFIs. Via a second search step in the Human Metabolome Database (HMDB), the Food Database (FooDB) and Phenol-Explorer, the specificity of the candidate BFIs was evaluated, followed by an evaluation of the validity of the specific candidate BFIs, via pre-defined criteria. Results In total, 37 papers were included for cocoa and 8 papers for liquorice. For cocoa, 164 unique candidate BFIs were obtained, and for liquorice, four were identified in total. Despite the high number of identified BFIs for cocoa, none of the metabolites was specific. Therefore, the validity of these compounds was not further examined. For liquorice intake, 18-glycyrrhetinic acid (18-GA) was found to have the highest assumed validity. Conclusions For cocoa, specific BFIs were missing, mainly because the individual BFIs were also found in foods having a similar composition, such as tea (polyphenols) or coffee (caffeine). However, a combination of individual BFIs might lead to discriminating profiles between cocoa (products) and foods with a similar composition. Therefore, studies directly comparing the consumption of cocoa to these similar products are needed, enabling efforts to find a unique profile per product. For liquorice, we identified 18-GA as a promising BFI; however, important information on its validity is missing; thus, more research is necessary. Our findings indicate a need for more studies to determine acceptable BFIs for both cocoa and liquorice.
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- 2018
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6. Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
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Enrique Almanza-Aguilera, Daniela Ceballos-Sánchez, David Achaintre, Joseph A Rothwell, Nasser Laouali, Gianluca Severi, Verena Katzke, Theron Johnson, Matthias B Schulze, Domenico Palli, Giuliana Gargano, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Augustin Scalbert, and Raul Zamora-Ros
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urine ,catechin ,epicatechin ,flavan-3-ols ,biomarkers ,intake ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This study examines the correlation of acute and habitual dietary intake of flavan-3-ol monomers, proanthocyanidins, theaflavins, and their main food sources with the urinary concentrations of (+)-catechin and (-)-epicatechin in the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (N = 419, men and women) provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day. Acute and habitual dietary data were collected using a standardized 24-HDR software and a validated dietary questionnaire, respectively. Intake of flavan-3-ols was estimated using the Phenol-Explorer database. Concentrations of (+)-catechin and (-)-epicatechin in 24-h urine were analyzed using tandem mass spectrometry after enzymatic deconjugation. Simple and partial Spearman’s correlations showed that urinary concentrations of (+)-catechin, (-)-epicatechin and their sum were more strongly correlated with acute than with habitual intake of individual and total monomers (acute rpartial = 0.13–0.54, p < 0.05; and habitual rpartial = 0.14–0.28, p < 0.01), proanthocyanidins (acute rpartial = 0.24–0.49, p < 0.001; and habitual rpartial = 0.10–0.15, p < 0.05), theaflavins (acute rpartial = 0.22–0.31, p < 0.001; and habitual rpartial = 0.20–0.26, p < 0.01), and total flavan-3-ols (acute rpartial = 0.40–0.48, p < 0.001; and habitual rpartial = 0.23–0.33, p < 0.001). Similarly, urinary concentrations of flavan-3-ols were weakly correlated with both acute (rpartial = 0.12–0.30, p < 0.05) and habitual intake (rpartial = 0.10–0.27, p < 0.05) of apple and pear, stone fruits, berries, chocolate and chocolate products, cakes and pastries, tea, herbal tea, wine, red wine, and beer and cider. Moreover, all comparable correlations were stronger for urinary (-)-epicatechin than for (+)-catechin. In conclusion, our data support the use of urinary concentrations of (+)-catechin and (-)-epicatechin, especially as short-term nutritional biomarkers of dietary catechin, epicatechin and total flavan-3-ol monomers.
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- 2021
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7. Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus
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Enrique Almanza-Aguilera, Álvaro Hernáez, Dolores Corella, Albert Sanllorente, Emilio Ros, Olga Portolés, Julieta Valussi, Ramon Estruch, Oscar Coltell, Isaac Subirana, Silvia Canudas, Cristina Razquin, Gemma Blanchart, Lara Nonell, Montserrat Fitó, and Olga Castañer
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transcriptome ,microarray ,signaling pathways ,cancer ,type 2 diabetes ,Medicine - Abstract
We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini–Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant “upregulation” and ≤ −2.0 “downregulation”). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, −log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, −log(p-value) = 2.03) and paxillin (z-score = 2.33, −log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = −2.14, −log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.
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- 2020
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8. Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome
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Vanessa Bullón-Vela, Itziar Abete, Maria Angeles Zulet, Yifan Xu, Miguel A. Martínez-González, Carmen Sayón-Orea, Miguel Ruiz-Canela, Estefanía Toledo, Vicente Martín Sánchez, Ramon Estruch, Rosa María Lamuela-Raventós, Enrique Almanza-Aguilera, Montserrat Fitó, Jordi Salas-Salvadó, Andrés Díaz-López, Francisco J. Tinahones, Josep A. Tur, Dora Romaguera, Jadwiga Konieczna, Xavier Pintó, Lidia Daimiel, Ana Rodriguez-Mateos, and José Alfredo Martínez
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antioxidant ,inflammation ,liver enzymes ,metabolic syndrome ,non-alcoholic fatty liver disease ,resveratrol ,Organic chemistry ,QD241-441 - Abstract
Metabolic syndrome (MetS) components are strongly associated with increased risk of non-alcoholic fatty liver disease (NAFLD) development. Several studies have supported that resveratrol is associated with anti-inflammatory and antioxidant effects on health status. The main objective of this study was to assess the putative associations between some urinary resveratrol phase II metabolites, cardiometabolic, and liver markers in individuals diagnosed with MetS. In this cross-sectional study, 266 participants from PREDIMED Plus study (PREvención con DIeta MEDiterránea) were divided into tertiles of total urinary resveratrol phase II metabolites (sum of five resveratrol conjugation metabolites). Urinary resveratrol metabolites were analyzed by ultra- performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS), followed by micro-solid phase extraction (µ-SPE) method. Liver function markers were assessed using serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT). Moreover, lipid profile was measured by triglycerides, very-low-density lipoprotein cholesterol (VLDL-c), and total cholesterol/high-density lipoprotein ratio (total cholesterol/HDL). Linear regression adjusted models showed that participants with higher total urine resveratrol concentrations exhibited improved lipid and liver markers compared to the lowest tertile. For lipid determinations: log triglycerides (βT3= −0.15, 95% CI; −0.28, −0.02, p-trend = 0.030), VLDL-c, (βT3= −4.21, 95% CI; −7.97, −0.46, p-trend = 0.039), total cholesterol/HDL ratio Moreover, (βT3= −0.35, 95% CI; −0.66, −0.03, p-trend = 0.241). For liver enzymes: log AST (βT3= −0.12, 95% CI; −0.22, −0.02, p-trend = 0.011, and log GGT (βT3= −0.24, 95% CI; −0.42, −0.06, p-trend = 0.002). However, there is no difference found on glucose variables between groups. To investigate the risk of elevated serum liver markers, flexible regression models indicated that total urine resveratrol metabolites were associated with a lower risk of higher ALT (169.2 to 1314.3 nmol/g creatinine), AST (599.9 to 893.8 nmol/g creatinine), and GGT levels (169.2 to 893.8 nmol/g creatinine). These results suggested that higher urinary concentrations of some resveratrol metabolites might be associated with better lipid profile and hepatic serum enzymes. Moreover, urinary resveratrol excreted showed a reduced odds ratio for higher liver enzymes, which are linked to NAFLD.
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- 2020
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9. Acilcarnitinas en plasma y riesgo de insuficiencia cardiaca y fibrilación auricular: el estudio Prevención con dieta mediterránea
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Miguel Ruiz-Canela, Marta Guasch-Ferré, Cristina Razquin, Estefanía Toledo, Pablo Hernández-Alonso, Clary B. Clish, Jun Li, Clemens Wittenbecher, Courtney Dennis, Ángel Alonso-Gómez, Enrique Almanza-Aguilera, Liming Liang, Dolores Corella, Enrique Gómez-Gracia, Ramón Estruch, Miguel Fiol, José Lapetra, Lluis Serra-Majem, Emilio Ros, Fernando Arós, Jordi Salas-Salvadó, Frank B. Hu, and Miguel Ángel Martínez-González
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Cardiology and Cardiovascular Medicine - Published
- 2022
10. Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
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Mercedes Gil-Lespinard, Jazmín Castañeda, Enrique Almanza-Aguilera, Jesús Humberto Gómez, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Cristina Lasheras, Esther Molina-Montes, José María Huerta, Aurelio Barricarte, Pilar Amiano, Emily Sonestedt, Marisa da Silva, Ingegerd Johansson, Johan Hultdin, Anne M. May, Nita G. Forouhi, Alicia K. Heath, Heinz Freisling, Elisabete Weiderpass, Augustin Scalbert, Raul Zamora-Ros, Almanza-Aguilera, Enrique [0000-0002-4805-0774], Kyrø, Cecilie [0000-0002-9083-8960], Masala, Giovanna [0000-0002-5758-9069], Tumino, Rosario [0000-0003-2666-414X], Sacerdote, Carlotta [0000-0002-8008-5096], Skeie, Guri [0000-0003-2476-4251], Molina-Montes, Esther [0000-0002-0428-2426], Huerta, José María [0000-0002-9637-3869], Sonestedt, Emily [0000-0002-0747-4562], da Silva, Marisa [0000-0003-1215-8625], Johansson, Ingegerd [0000-0002-9227-8434], Hultdin, Johan [0000-0002-9599-0961], Heath, Alicia K [0000-0001-6517-1300], Freisling, Heinz [0000-0001-8648-4998], Weiderpass, Elisabete [0000-0003-2237-0128], Zamora-Ros, Raul [0000-0002-6236-6804], and Apollo - University of Cambridge Repository
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obesity ,Nutrition and Dietetics ,polyphenol ,intake ,body weight ,cohort ,EPIC ,Physiology ,Estrès oxidatiu ,Clinical Biochemistry ,Pes corporal ,Polyphenols ,Cell Biology ,Biochemistry ,Article ,Näringslära ,Oxidative stress ,Polifenols ,Obesitat ,Molecular Biology - Abstract
Peer reviewed: True, Funder: International Agency for Research on Cancer (IARC), Funder: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Funder: NIHR Imperial Biomedical Research Centre (BRC), Funder: Danish Cancer Society (Denmark), Funder: Ligue Contre le Cancer, Funder: Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Funder: Institut National de la Santé et de la Recherche Médicale (INSERM), Funder: German Cancer Aid, Funder: German Cancer Research Center (DKFZ), Funder: German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Funder: Federal Ministry of Education and Research (BMBF), Funder: Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Funder: Compagnia di San Paolo, Funder: National Research Council, Funder: Dutch Ministry of Public Health, Welfare and Sports (VWS), Funder: Netherlands Cancer Registry (NKR), Funder: LK Research Funds, Funder: Dutch Prevention Funds, Funder: Dutch ZON (Zorg Onderzoek Nederland), Funder: World Cancer Research Fund (WCRF), Funder: Statistics Netherlands, Funder: Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Funder: Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, Funder: Catalan Institute of Oncology—ICO, Funder: Swedish Cancer Society, Funder: Swedish Research Council, Funder: County Councils of Skåne and Västerbotten, Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
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- 2023
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11. Association between classes and subclasses of polyphenol intake and 5‐year body weight changes in the EPIC‐PANACEA study
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Jazmin Castañeda, Mercedes Gil‐Lespinard, Enrique Almanza‐Aguilera, Fjorida Llaha, Jesús‐Humberto Gómez, Nicola Bondonno, Anne Tjønneland, Kim Overvad, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Magritt Brustad, Cristina Lasheras, Esther Molina‐Montes, María‐Dolores Chirlaque, Aurelio Barricarte, Emily Sonestedt, Marisa da Silva, Ingegerd Johansson, Johan Hultdin, Anne M. May, Nita G. Forouhi, Alicia K. Heath, Heinz Freisling, Elisabete Weiderpass, Augustin Scalbert, Raul Zamora‐Ros, Castañeda, Jazmin [0000-0002-8521-9946], Gil-Lespinard, Mercedes [0000-0002-7387-2139], Almanza-Aguilera, Enrique [0000-0002-4805-0774], Llaha, Fjorida [0000-0003-0534-6484], Gómez, Jesús-Humberto [0000-0001-8442-8327], Bondonno, Nicola [0000-0001-5905-444X], Tjønneland, Anne [0000-0003-4385-2097], Overvad, Kim [0000-0001-6429-7921], Katzke, Verena [0000-0002-6509-6555], Schulze, Matthias B [0000-0002-0830-5277], Masala, Giovanna [0000-0002-5758-9069], Agnoli, Claudia [0000-0003-4472-1179], Tumino, Rosario [0000-0003-2666-414X], Sacerdote, Carlotta [0000-0002-8008-5096], Skeie, Guri [0000-0003-2476-4251], Brustad, Magritt [0000-0003-0114-5271], Lasheras, Cristina [0000-0003-0482-4229], Molina-Montes, Esther [0000-0002-0428-2426], Chirlaque, María-Dolores [0000-0001-9242-3040], Barricarte, Aurelio [0000-0001-6750-1270], Sonestedt, Emily [0000-0002-0747-4562], da Silva, Marisa [0000-0003-1215-8625], Johansson, Ingegerd [0000-0002-9227-8434], Hultdin, Johan [0000-0002-9599-0961], Forouhi, Nita G [0000-0002-5041-248X], Heath, Alicia K [0000-0001-6517-1300], Freisling, Heinz [0000-0001-8648-4998], Weiderpass, Elisabete [0000-0003-2237-0128], Scalbert, Augustin [0000-0001-6651-6710], Zamora-Ros, Raul [0000-0002-6236-6804], and Apollo - University of Cambridge Repository
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Male ,Flavonoids ,Nutrition and Dietetics ,Coumaric Acids ,Endocrinology, Diabetes and Metabolism ,Body Weight ,Medicine (miscellaneous) ,Polyphenols ,Weight Gain ,Coffee ,Diet ,Näringslära ,Endocrinology ,Neoplasms ,Humans ,Female ,Prospective Studies - Abstract
Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5years. Methods: A total of 349,165 men and women aged 25 to 70years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries. Body weight was measured at baseline and at follow-up after a median time of 5years. Polyphenol intake, including four main polyphenol classes and eighteen subclasses, was estimated using validated dietary questionnaires and Phenol-Explorer. Multilevel mixed linear regression models were used to estimate the associations. Results: Participants gained, on average, 2.6 kg (5.0 kg) over 5years. Total flavonoids intake was inversely associated with body weight change (-0.195kg/5 years, 95% CI: -0.262 to -0.128). However, the intake of total polyphenols (0.205kg/5 years, 95% CI: 0.138 to 0.272) and intake of hydroxycinnamic acids (0.324kg/5 years, 95% CI: 0.267 to 0.381) were positively associated with body weight gain. In analyses stratified by coffee consumption, hydroxycinnamic acid intake was positively associated with body weight gain in coffee consumers (0.379kg/5 years, 95% CI: 0.319 to 0.440), but not in coffee nonconsumers (-0.179kg/5 years, 95% CI: -0.490 to 0.133). Conclusions: Higher intakes of flavonoids and their subclasses are inversely associated with a modest body weight change. Results regarding hydroxycinnamic acids in coffee consumers require further investigation., Consejo Nacional de Ciencia y Tecnologia (CONACyT) 693636, Instituto de Salud Carlos III CD20/ 00071 CPII20/00009 FI19/00185 PI18/ 00191
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- 2022
12. Blood and Urinary Flavonoids
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Enrique Almanza-Aguilera, David Bars-Cortina, Fjorida Llaha, and Raul Zamora-Ros
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- 2022
13. High-density lipoprotein functional traits and coronary artery disease in a general population: a case–cohort study
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Camille Lassale, Albert Sanllorente, Montserrat Fitó, Daniel Muñoz-Aguayo, Mar Soldado, Olga Castañer, Gemma Blanchart, Jaume Marrugat, Roberto Elosua, Joan Vila, Álvaro Hernáez, Enrique Almanza-Aguilera, and Isaac Subirana
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education.field_of_study ,medicine.medical_specialty ,Epidemiology ,business.industry ,Cholesterol, HDL ,Population ,Coronary Artery Disease ,medicine.disease ,Cohort Studies ,Coronary artery disease ,chemistry.chemical_compound ,High-density lipoprotein ,chemistry ,Risk Factors ,Internal medicine ,Cardiology ,Humans ,Medicine ,Lipoproteins, HDL ,Cardiology and Cardiovascular Medicine ,business ,education ,Cohort study - Published
- 2020
14. Plasma acylcarnitines and risk of incident heart failure and atrial fibrillation: the Prevención con dieta mediterránea study
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Miguel Ruiz-Canela, Marta Guasch-Ferré, Cristina Razquin, Estefanía Toledo, Pablo Hernández-Alonso, Clary B. Clish, Jun Li, Clemens Wittenbecher, Courtney Dennis, Ángel Alonso-Gómez, Enrique Almanza-Aguilera, Liming Liang, Dolores Corella, Enrique Gómez-Gracia, Ramón Estruch, Miguel Fiol, José Lapetra, Lluis Serra-Majem, Emilio Ros, Fernando Arós, Jordi Salas-Salvadó, Frank B. Hu, and Miguel Ángel Martínez-González
- Subjects
Heart Failure ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Risk Factors ,Carnitine ,Atrial Fibrillation ,Mediterranea ,Humans ,Nuts ,General Medicine ,Obesity ,Diet, Mediterranean ,Olive Oil - Abstract
Fatty acid metabolic dysregulation in mitochondria is a common mechanism involved in the development of heart failure (HF) and atrial fibrillation (AF). We evaluated the association between plasma acylcarnitine levels and the incidence of HF or AF, and whether the mediterranean diet (MedDiet) may attenuate the association between acylcarnitines and HF or AF risk.Two case-control studies nested within the Prevención con dieta mediterránea (PREDIMED) trial. High cardiovascular risk participants were recruited in Spain: 326 incident HF and 509 AF cases individually matched to 1 to 3 controls. Plasma acylcarnitines were measured with high-throughput liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were fitted to estimate multivariable OR and 95%CI. Additive and multiplicative interactions were assessed by intervention group, obesity (body mass index ≥ 30 kg/mElevated levels of medium- and long-chain acylcarnitines were associated with increased HF risk (adjusted ORAmong individuals at high cardiovascular risk, elevated long-chain acylcarnitines were associated with a higher risk of incident HF and AF. An intervention with MedDiet+extra-virgin olive oil may reduce AF risk associated with long-chain acylcarnitines. This trial was registered at controlled-trials.com (Identifier: ISRCTN35739639).
- Published
- 2021
15. Non-targeted metabolomic biomarkers and metabotypes of type 2 diabetes: A cross-sectional study of PREDIMED trial participants
- Author
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Alex Sánchez-Pla, Jordi Salas-Salvadó, Rafael Llorach, Dolores Corella, Ramon Estruch, Cristina Andres-Lacueva, Rosa Vázquez-Fresno, Francesc Carmona, Enrique Almanza-Aguilera, José V. Sorlí, and Mireia Urpi-Sarda
- Subjects
Male ,0301 basic medicine ,Oncology ,Non targeted ,endocrine system diseases ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,Diet, Mediterranean ,Logistic regression ,Diabetis no-insulinodependent ,Endocrinology ,Risk Factors ,Non-insulin-dependent diabetes ,Dietoteràpia ,education.field_of_study ,Factors de risc en les malalties ,Biochemical markers ,General Medicine ,Middle Aged ,Metabolisme ,Metabolòmica ,Cardiovascular Diseases ,Marcadors bioquímics ,Metabolome ,Female ,medicine.medical_specialty ,Risk factors in diseases ,Population ,Urinalysis ,03 medical and health sciences ,Medicina preventiva ,Metabolomics ,Internal medicine ,Internal Medicine ,medicine ,Humans ,education ,Aged ,Preventive medicine ,Receiver operating characteristic ,business.industry ,Diet therapy ,nutritional and metabolic diseases ,medicine.disease ,Predimed ,Metabolism ,Cross-Sectional Studies ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,business ,human activities ,Biomarkers ,Diabetic Angiopathies - Abstract
Aim. - To characterize the urinary metabolomic fingerprint and multi-metabolite signature associated with type 2 diabetes (T2D), and to classify the population into metabotypes related to T2D. Methods. - A metabolomics analysis using the 1 H-NMR-based, non-targeted metabolomic approach was conducted to determine the urinary metabolomic fingerprint of T2D compared with non-T2D participants in the PREDIMED trial. The discriminant metabolite fingerprint was subjected to logistic regression analysis and ROC analyses to establish and to assess the multi-metabolite signature of T2D prevalence, respectively. Metabotypes associated with T2D were identified using the k-means algorithm. Results. - A total of 33 metabolites were significantly different (P < 0.05) between T2D and non-T2D participants. The multi-metabolite signature of T2D comprised high levels of methylsuccinate, alanine, dimethylglycine and guanidoacetate, and reduced levels of glutamine, methylguanidine, 3-hydroxymandelate and hippurate, and had a 96.4% AUC, which was higher than the metabolites on their own and glucose. Amino-acid and carbohydrate metabolism were the main metabolic alterations in T2D, and various metabotypes were identified in the studied population. Among T2D participants, those with a metabotype of higher levels of phenylalanine, phenylacetylglutamine, p-cresol and acetoacetate had significantly higher levels of plasma glucose. Conclusion. - The multi-metabolite signature of T2D highlights the altered metabolic fingerprint associated mainly with amino-acid, carbohydrate and microbiota metabolism. Metabotypes identified in this patient population could be related to higher risk of long-term cardiovascular events and therefore require further studies. Metabolomics is a useful tool for elucidating the metabolic complexity and interindividual variation in T2D towards the development of stratified precision nutrition and medicine
- Published
- 2019
16. Urinary concentrations of (+)-catechin and (-)-epicatechin as biomarkers of dietary intake of flavan-3-ols in the european prospective investigation into cancer and nutrition (epic) study
- Author
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Matthias B. Schulze, David Achaintre, Enrique Almanza-Aguilera, Rosario Tumino, Joseph A. Rothwell, Theron Johnson, Verena Katzke, Gianluca Severi, Carlotta Sacerdote, Nasser Laouali, Domenico Palli, Maria Santucci de Magistris, Augustin Scalbert, Raul Zamora-Ros, Daniela Ceballos-Sánchez, Giuliana Gargano, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Universität Potsdam, Università degli studi di Napoli Federico II, Instituto de Salud Carlos III, ISCIII: PI18/00191, European Regional Development Fund, ERDF, Funding: This research was funded by the by the Institute of Health Carlos III through the grant PI18/00191 (co-funded by European Regional Development Fund. ERDF, a way to build Europe), and from the 553/C/2019 project, funded by La Marató de TV-3. The national EPIC cohorts are supported by the French National Cancer Institute (L’Institut National du Cancer, INCA Grant No. 2009-139), Ligue contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center (DKFZ), German Federal Ministry of Education and Research (Germany), the Hellenic Health Foundation (Greece), Italian Association for Research on Cancer, and Compagnia San Paolo (Italy). IDIBELL acknowledges support from the Generalitat de Catalunya through the CERCA Program. E.A.-A. and R.Z.-R. wish to thank the 'Sara Borrell' (CD20/00071) and the 'Miguel Servet' (CP CPII20/00009) programs from the Institute of Health Carlos III (co-funded by the European Social Fund (ESF)—ESF investing in your future).
- Subjects
Male ,Questionnaires ,030309 nutrition & dietetics ,Urine ,Catechin ,chemistry.chemical_compound ,Eating ,Medicine ,TX341-641 ,Food science ,Prospective Studies ,Epicatechin ,0303 health sciences ,Nutrition and Dietetics ,Biochemical markers ,Middle Aged ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Europe ,Proanthocyanidin ,Marcadors bioquímics ,Intake ,Female ,Adult ,Urinary system ,Qüestionaris ,Diet Surveys ,Article ,Statistics, Nonparametric ,Flavan-3-ols ,03 medical and health sciences ,Herbal tea ,Flavan ,Biflavonoids ,Humans ,Proanthocyanidins ,030304 developmental biology ,Aged ,Wine ,Flavonoids ,business.industry ,Nutrition. Foods and food supply ,Orina ,Diet ,Nutrition Assessment ,chemistry ,Food ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Aliments ,business ,EPIC ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Biomarkers ,Food Science - Abstract
This study examines the correlation of acute and habitual dietary intake of flavan-3-ol monomers, proanthocyanidins, theaflavins, and their main food sources with the urinary concentrations of (+)-catechin and (-)-epicatechin in the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (N = 419, men and women) provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day. Acute and habitual dietary data were collected using a standardized 24-HDR software and a validated dietary questionnaire, respectively. Intake of flavan-3-ols was estimated using the Phenol-Explorer database. Concentrations of (+)-catechin and (-)-epicatechin in 24-h urine were analyzed using tandem mass spectrometry after enzymatic deconjugation. Simple and partial Spearman’s correlations showed that urinary concentrations of (+)-catechin, (-)-epicatechin and their sum were more strongly correlated with acute than with habitual intake of individual and total monomers (acute rpartial = 0.13–0.54, p <, 0.05, and habitual rpartial = 0.14–0.28, p <, 0.01), proanthocyanidins (acute rpartial = 0.24–0.49, p <, 0.001, and habitual rpartial = 0.10–0.15, p <, 0.05), theaflavins (acute rpartial = 0.22–0.31, p <, and habitual rpartial = 0.20–0.26, p <, 0.01), and total flavan-3-ols (acute rpartial = 0.40–0.48, p <, and habitual rpartial = 0.23–0.33, p <, 0.001). Similarly, urinary concentrations of flavan-3-ols were weakly correlated with both acute (rpartial = 0.12–0.30, p <, 0.05) and habitual intake (rpartial = 0.10–0.27, p <, 0.05) of apple and pear, stone fruits, berries, chocolate and chocolate products, cakes and pastries, tea, herbal tea, wine, red wine, and beer and cider. Moreover, all comparable correlations were stronger for urinary (-)-epicatechin than for (+)-catechin. In conclusion, our data support the use of urinary concentrations of (+)-catechin and (-)-epicatechin, especially as short-term nutritional biomarkers of dietary catechin, epicatechin and total flavan-3-ol monomers.
- Published
- 2021
17. Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence
- Author
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Montserrat Fitó, Enrique Almanza-Aguilera, Núria Agustí, Álvaro Hernáez, Josep Julve, Marta Farràs, and Olga Castañer
- Subjects
0301 basic medicine ,Cancer Research ,Mediterranean diet ,Biology ,Diet, Mediterranean ,03 medical and health sciences ,chemistry.chemical_compound ,Squalene ,0302 clinical medicine ,Oleuropein ,Neoplasms ,Oleocanthal ,Animals ,Humans ,Food science ,Fatty acids ,Cancer ,Incidence ,Terpenoid ,Phenolic compounds ,Tyrosol ,Oleic acid ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,Hydroxytyrosol ,Olive oil - Abstract
Virgin olive oil is a characteristic component and the main source of fat of the Mediterranean diet. It is a mix of high-value health compounds, including monounsaturated fatty acids (mainly oleic acid), simple phenols (such as hydroxytyrosol and tyrosol), secoiridoids (such as oleuropein, oleocanthal), flavonoids, and terpenoids (such as squalene). Olive oil consumption has been shown to improve different aspects of human health and has been associated with a lower risk of cancer. However, the underlying cellular mechanisms involved in such effects are still poorly defined, but seem to be related to a promotion of apoptosis, modulation of epigenetic patterns, blockade of cell cycle, and angiogenesis regulation. The aim of this review is to update the current associations of cancer risk with the Mediterranean diet, olive oil consumption and its main components. In addition, the identification of key olive oil components involved in anticarcinogenic mechanisms and pathways according to experimental models is also addressed.
- Published
- 2021
18. Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus
- Author
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Albert Sanllorente, Olga Castañer, Enrique Almanza-Aguilera, Álvaro Hernáez, Julieta Valussi, Isaac Subirana, Olga Portolés, Cristina Razquin, Emilio Ros, Gemma Blanchart, Montserrat Fitó, Silvia Canudas, Oscar Coltell, Ramon Estruch, Dolores Corella, and Lara Nonell
- Subjects
endocrine system diseases ,Microarray ,Integrin ,T cells ,lcsh:Medicine ,030209 endocrinology & metabolism ,Inflammation ,Peripheral blood mononuclear cell ,Article ,Diabetis no-insulinodependent ,Transcriptome ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Downregulation and upregulation ,medicine ,cancer ,Non-insulin-dependent diabetes ,Càncer ,030304 developmental biology ,Cancer ,0303 health sciences ,biology ,business.industry ,lcsh:R ,nutritional and metabolic diseases ,General Medicine ,signaling pathways ,chemistry ,Cèl·lules T ,Guanosine diphosphate ,Cancer research ,biology.protein ,type 2 diabetes ,medicine.symptom ,Signal transduction ,business ,transcriptome ,microarray - Abstract
We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini&ndash, Hochberg-adjusted p-value were >, 1.30 and their absolute z-scores were >, 2.0 (&ge, 2.0 meant &ldquo, upregulation&rdquo, and &le, &minus, 2.0 &ldquo, downregulation&rdquo, ). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, &minus, log(p-value) = 32.3, 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, &minus, log(p-value) = 2.03) and paxillin (z-score = 2.33, &minus, log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = &minus, 2.14, &minus, log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.
- Published
- 2020
19. Transcriptional response to a Mediterranean diet intervention exerts a modulatory effect on neuroinflammation signaling pathway
- Author
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Olga Portolés, Lara Nonell, Montserrat Fitó, Álvaro Hernáez, Oscar Coltell, Miguel Ruiz-Canela, Dolores Corella, Rafael de la Torre, Enrique Almanza-Aguilera, Ramon Estruch, Julieta Valussi, Isaac Subirana, Emilio Ros, Daniel Muñoz Aguayo, Olga Castañer, and Jordi Salas-Salvadó
- Subjects
0301 basic medicine ,Microarray ,Mediterranean diet ,Medicine (miscellaneous) ,Biology ,Bioinformatics ,Diet, Mediterranean ,Transcriptome ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Intervention (counseling) ,Humans ,Nuts ,Plant Oils ,Beneficial effects ,Olive Oil ,Neuroinflammation ,030109 nutrition & dietetics ,Nutrition and Dietetics ,General Neuroscience ,General Medicine ,stomatognathic diseases ,Cardiovascular Diseases ,Neuroinflammatory Diseases ,Leukocytes, Mononuclear ,Transcriptional response ,Signal transduction ,human activities ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Background: The Traditional Mediterranean Diet (TMD) is known to have beneficial effects on several chronic diseases. However, data concerning the whole transcriptome modulation of the TMD are scar...
- Published
- 2020
20. Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome
- Author
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Jordi Salas-Salvadó, Lidia Daimiel, Francisco J. Tinahones, Rosa M. Lamuela-Raventós, Estefanía Toledo, Yifan Xu, Jadwiga Konieczna, Maria Angeles Zulet, Josep A. Tur, Dora Romaguera, Andrés Díaz-López, Miguel Ruiz-Canela, Enrique Almanza-Aguilera, Miguel Ángel Martínez-González, Ana Rodriguez-Mateos, Itziar Abete, Vanessa Bullón-Vela, José Alfredo Martínez, Vicente Martín Sánchez, Carmen Sayón-Orea, Xavier Pintó, Ramon Estruch, and Montserrat Fitó
- Subjects
Male ,riesgo ,Síndrome metabòlica ,antioxidant ,030309 nutrition & dietetics ,humanos ,Pharmaceutical Science ,Urine ,resveratrol ,Resveratrol ,Analytical Chemistry ,chemistry.chemical_compound ,0302 clinical medicine ,Drug Discovery ,mediana edad ,miocardio ,anciano ,0303 health sciences ,medicine.diagnostic_test ,Malalties del fetge ,Fatty liver ,Middle Aged ,Inflamació ,Metabolic syndrome ,liver enzymes ,3. Good health ,Liver ,Chemistry (miscellaneous) ,hígado ,Molecular Medicine ,Female ,030211 gastroenterology & hepatology ,Risk ,medicine.medical_specialty ,Article ,metabolic syndrome ,lcsh:QD241-441 ,03 medical and health sciences ,lcsh:Organic chemistry ,Internal medicine ,medicine ,Humans ,Physical and Theoretical Chemistry ,Liver diseases ,Aged ,Inflammation ,Creatinine ,Models, Statistical ,business.industry ,Myocardium ,Organic Chemistry ,non-alcoholic fatty liver disease ,medicine.disease ,Cross-Sectional Studies ,Endocrinology ,chemistry ,inflammation ,Liver function ,Lipid profile ,business ,Biomarkers ,estudios transversales ,Lipoprotein - Abstract
Metabolic syndrome (MetS) components are strongly associated with increased risk of non-alcoholic fatty liver disease (NAFLD) development. Several studies have supported that resveratrol is associated with anti-inflammatory and antioxidant effects on health status. The main objective of this study was to assess the putative associations between some urinary resveratrol phase II metabolites, cardiometabolic, and liver markers in individuals diagnosed with MetS. In this cross-sectional study, 266 participants from PREDIMED Plus study (PREvenció, n con DIeta MEDiterrá, nea) were divided into tertiles of total urinary resveratrol phase II metabolites (sum of five resveratrol conjugation metabolites). Urinary resveratrol metabolites were analyzed by ultra- performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS), followed by micro-solid phase extraction (µ, SPE) method. Liver function markers were assessed using serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT). Moreover, lipid profile was measured by triglycerides, very-low-density lipoprotein cholesterol (VLDL-c), and total cholesterol/high-density lipoprotein ratio (total cholesterol/HDL). Linear regression adjusted models showed that participants with higher total urine resveratrol concentrations exhibited improved lipid and liver markers compared to the lowest tertile. For lipid determinations: log triglycerides (&beta, T3= &minus, 0.15, 95% CI, &minus, 0.28, &minus, 0.02, p-trend = 0.030), VLDL-c, (&beta, 4.21, 95% CI, 7.97, &minus, 0.46, p-trend = 0.039), total cholesterol/HDL ratio Moreover, (&beta, 0.35, 95% CI, 0.66, &minus, 0.03, p-trend = 0.241). For liver enzymes: log AST (&beta, 0.12, 95% CI, 0.22, &minus, 0.02, p-trend = 0.011, and log GGT (&beta, 0.24, 95% CI, 0.42, &minus, 0.06, p-trend = 0.002). However, there is no difference found on glucose variables between groups. To investigate the risk of elevated serum liver markers, flexible regression models indicated that total urine resveratrol metabolites were associated with a lower risk of higher ALT (169.2 to 1314.3 nmol/g creatinine), AST (599.9 to 893.8 nmol/g creatinine), and GGT levels (169.2 to 893.8 nmol/g creatinine). These results suggested that higher urinary concentrations of some resveratrol metabolites might be associated with better lipid profile and hepatic serum enzymes. Moreover, urinary resveratrol excreted showed a reduced odds ratio for higher liver enzymes, which are linked to NAFLD.
- Published
- 2020
21. Biomarkers of food intake for cocoa and liquorice (products): a systematic review
- Author
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Lydia A. Afman, Mireia Urpi-Sarda, Elske M. Brouwer-Brolsma, Enrique Almanza-Aguilera, Charlotte C J R Michielsen, and Universitat de Barcelona
- Subjects
0301 basic medicine ,Isi web of science ,Food intake ,lcsh:QH426-470 ,Xocolata ,Endocrinology, Diabetes and Metabolism ,Liquorice ,lcsh:TX341-641 ,Review ,Biology ,Voeding, Metabolisme en Genomica ,03 medical and health sciences ,Licorice ,Cocoa ,Voeding ,Genetics ,Metabolites ,Metabolomics ,Human Metabolome Database ,Chocolate ,VLAG ,Nutrition ,Human Nutrition & Health ,Global Nutrition ,Wereldvoeding ,Cacao ,Food frequency ,business.industry ,Dietary exposure ,Humane Voeding & Gezondheid ,Biochemical markers ,Objective measurement ,food and beverages ,Metabòlits ,Metabolism and Genomics ,Biotechnology ,lcsh:Genetics ,030104 developmental biology ,Systematic review ,Metabolisme en Genomica ,Marcadors bioquímics ,FooDB ,Regalèssia ,Licorice (Plant) ,Nutrition, Metabolism and Genomics ,Cacau ,business ,lcsh:Nutrition. Foods and food supply ,Biomarkers - Abstract
Background To unravel true links between diet and health, it is important that dietary exposure is accurately measured. Currently, mainly self-reporting methods (e.g. food frequency questionnaires and 24-h recalls) are used to assess food intake in epidemiological studies. However, these traditional instruments are subjective measures and contain well-known biases. Especially, estimating the intake of the group of confectionary products, such as products containing cocoa and liquorice, remains a challenge. The use biomarkers of food intake (BFIs) may provide a more objective measurement. However, an overview of current candidate biomarkers and their validity is missing for both cocoa- and liquorice-containing foods. Objective The purpose of the current study was to (1) identify currently described candidate BFIs for cocoa (products) and liquorice, (2) to evaluate the validity of these identified candidate BFIs and (3) to address further validation and/or identification work to be done. Methods This systematic review was based on a comprehensive literature search of three databases (PubMed, Scopus and ISI web of Science), to identify candidate BFIs. Via a second search step in the Human Metabolome Database (HMDB), the Food Database (FooDB) and Phenol-Explorer, the specificity of the candidate BFIs was evaluated, followed by an evaluation of the validity of the specific candidate BFIs, via pre-defined criteria. Results In total, 37 papers were included for cocoa and 8 papers for liquorice. For cocoa, 164 unique candidate BFIs were obtained, and for liquorice, four were identified in total. Despite the high number of identified BFIs for cocoa, none of the metabolites was specific. Therefore, the validity of these compounds was not further examined. For liquorice intake, 18-glycyrrhetinic acid (18-GA) was found to have the highest assumed validity. Conclusions For cocoa, specific BFIs were missing, mainly because the individual BFIs were also found in foods having a similar composition, such as tea (polyphenols) or coffee (caffeine). However, a combination of individual BFIs might lead to discriminating profiles between cocoa (products) and foods with a similar composition. Therefore, studies directly comparing the consumption of cocoa to these similar products are needed, enabling efforts to find a unique profile per product. For liquorice, we identified 18-GA as a promising BFI; however, important information on its validity is missing; thus, more research is necessary. Our findings indicate a need for more studies to determine acceptable BFIs for both cocoa and liquorice. Electronic supplementary material The online version of this article (10.1186/s12263-018-0610-x) contains supplementary material, which is available to authorized users.
- Published
- 2018
22. Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
- Author
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Rikard Landberg, Enrique Almanza-Aguilera, Cristina Andres-Lacueva, Carl Brunius, Mar Garcia-Aloy, Francisco J. Tinahones, M. Rosa Bernal-Lopez, Ricardo Gómez-Huelgas, and Francisco Madrid-Gambin
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Very low-density lipoprotein ,Mediterranean diet ,physical activity ,Dones ,030209 endocrinology & metabolism ,Reducing diests ,Creatine ,Diet, Mediterranean ,Biochemistry ,Phosphocreatine ,03 medical and health sciences ,chemistry.chemical_compound ,Plasma ,0302 clinical medicine ,Weight loss ,Internal medicine ,Overweight persons ,Metabolically healthy obesity ,Weight Loss ,medicine ,Metabolome ,Humans ,Metabolomics ,Women ,Obesity ,Exercise ,Life Style ,business.industry ,General Chemistry ,Middle Aged ,NMR ,Persones obeses ,030104 developmental biology ,Endocrinology ,chemistry ,Metabolòmica ,Case-Control Studies ,Dietes d'aprimament ,metabolically healthy obesity ,Female ,medicine.symptom ,hypocaloric diet ,business ,Lipoprotein - Abstract
Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted 1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism. Keywords: NMR; hypocaloric diet; metabolically healthy obesity; metabolomics; physical activity.
- Published
- 2018
23. Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1h-nmr-based untargeted metabolomics approach
- Author
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Mar Garcia-Aloy, Alex Sánchez, Francisco Madrid-Gambin, Rafael Llorach, Rosa Vázquez-Fresno, Dolores Corella, Ramon Estruch, Cristina Andres-Lacueva, Enrique Almanza-Aguilera, Mireia Urpi-Sarda, Francesc Carmona, and Universitat de Barcelona
- Subjects
0301 basic medicine ,Glutamina ,Mediterranean diet ,Physiology ,Endocrinology, Diabetes and Metabolism ,Metabolite ,Food habits ,Glutamine ,Clinical Biochemistry ,Microbiota intestinal ,Fisiologia ,Biology ,Urine ,Bioinformatics ,Espectroscòpia de ressonància magnètica nuclear ,Biochemistry ,03 medical and health sciences ,chemistry.chemical_compound ,Metabolomics ,Mediterranean cooking ,Congressos ,Cuina mediterrània ,Food science ,Molecular Biology ,Gastrointestinal microbiome ,Congresses ,Nuclear magnetic resonance spectroscopy ,Nutrition and Dietetics ,Nutritional epidemiology ,Hàbits alimentaris ,Biochemical markers ,Area under the curve ,Stepwise regression ,Orina ,030104 developmental biology ,Phenylacetylglutamine ,chemistry ,Metabolòmica ,Marcadors bioquímics ,Biomarker (medicine) - Abstract
The study of biomarkers of dietary patterns including the Mediterranean diet (MedDiet) is scarce and could improve the assessment of these patterns. Moreover, it could provide a better understanding of health benefits of dietary patterns in nutritional epidemiology. We aimed to determine a robust and accurate biomarker associated with a high adherence to a MedDiet pattern that included dietary assessment and its biological effect. In this cross-sectional study, we included 56 and 63 individuals with high (H-MDA) and low (L-MDA) MedDiet adherence categories, respectively, all from the Prevencion con Dieta Mediterranea trial. A 1H-NMR-based untargeted metabolomics approach was applied to urine samples. Multivariate statistical analyses were conducted to determine the metabolite differences between groups. A stepwise logistic regression and receiver operating characteristic curves were used to build and evaluate the prediction model for H-MDA. Thirty-four metabolites were identified as discriminant between H-MDA and L-MDA. The fingerprint associated with H-MDA included higher excretion of proline betaine and phenylacetylglutamine, among others, and decreased amounts of metabolites related to glucose metabolism. Three microbial metabolites - phenylacetylglutamine, p-cresol and 4-hydroxyphenylacetate - were included in the prediction model of H-MDA (95% specificity, 95% sensitivity and 97% area under the curve). The model composed of microbial metabolites was the biomarker that defined high adherence to a Mediterranean dietary pattern. The overall metabolite profiling identified reflects the metabolic modulation produced by H-MDA. The proposed biomarker may be a better tool for assessing and aiding nutritional epidemiology in future associations between H-MDA and the prevention or amelioration of chronic diseases.
- Published
- 2017
24. Urinary
- Author
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Francisco, Madrid-Gambin, Rafael, Llorach, Rosa, Vázquez-Fresno, Mireia, Urpi-Sarda, Enrique, Almanza-Aguilera, Mar, Garcia-Aloy, Ramon, Estruch, Dolores, Corella, and Cristina, Andres-Lacueva
- Subjects
Magnetic Resonance Spectroscopy ,Nutrigenomics ,Metabolome ,Humans ,Metabolomics ,Fabaceae ,Energy Metabolism ,Biomarkers ,Diet - Abstract
Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils, and beans), spot urine samples from a subcohort from the PREDIMED study were stratified using a validated food frequency questionnaire. Urine samples of nonpulse consumers (≤4 g/day of pulse intake) and habitual pulse consumers (≥25 g/day of pulse intake) were analyzed using a
- Published
- 2017
25. Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a
- Author
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Enrique, Almanza-Aguilera, Mireia, Urpi-Sarda, Rafael, Llorach, Rosa, Vázquez-Fresno, Mar, Garcia-Aloy, Francesc, Carmona, Alex, Sanchez, Francisco, Madrid-Gambin, Ramon, Estruch, Dolores, Corella, and Cristina, Andres-Lacueva
- Subjects
Aged, 80 and over ,Male ,Magnetic Resonance Spectroscopy ,Glutamine ,Middle Aged ,Diet, Mediterranean ,Gastrointestinal Microbiome ,Cresols ,Cross-Sectional Studies ,ROC Curve ,Humans ,Metabolomics ,Female ,Biomarkers ,Aged ,Phenylacetates - Abstract
The study of biomarkers of dietary patterns including the Mediterranean diet (MedDiet) is scarce and could improve the assessment of these patterns. Moreover, it could provide a better understanding of health benefits of dietary patterns in nutritional epidemiology. We aimed to determine a robust and accurate biomarker associated with a high adherence to a MedDiet pattern that included dietary assessment and its biological effect. In this cross-sectional study, we included 56 and 63 individuals with high (H-MDA) and low (L-MDA) MedDiet adherence categories, respectively, all from the Prevención con Dieta Mediterránea trial. A
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- 2016
26. Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
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Cristina Andres-Lacueva, Sara Tulipani, Mireia Urpi-Sarda, Jordi Salas-Salvadó, Francisco J. Tinahones, and Enrique Almanza-Aguilera
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Pharmacology ,medicine.medical_specialty ,endocrine system diseases ,business.industry ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Disease ,Bioinformatics ,medicine.disease ,Endocrinology ,Metabolomics ,Gluconeogenesis ,Internal medicine ,Diabetes mellitus ,medicine ,Lipolysis ,Pharmacology (medical) ,Glycolysis ,Prediabetes ,business - Abstract
Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead to the identification and discovery of diagnostic and prognostic T2DM biomarkers, in addition to elucidating disease pathways. In the present review, we summarize the distinct classes of metabolites that have been proposed as potential biomarkers for progressing stages of T2DM by metabolomic approaches. Several studies have demonstrated that the metabolism of carbohydrates, lipids, and amino acids is considerably altered in prediabetes and continue to vary over the course of T2DM progression. The identification of intermediate metabolites involved in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, lipolysis, and proteolysis have provided evidence of these metabolic dysfunctions. Finally, given the increasing worldwide incidence of T2DM and its related complications, research should focus on the impact of lifestyle factors, particularly diet, at the metabolomic level for better understanding and improved healthcare strategies.
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- 2015
27. trans -Lycopene from tomato juice attenuates inflammatory biomarkers in human plasma samples: An intervention trial
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Dolores Corella, Enrique Almanza-Aguilera, Palmira Valderas-Martinez, Ramon Estruch, Miriam Martínez-Huélamo, Sara Arranz-Martinez, Rosa M. Lamuela-Raventós, and Mariel Colmán-Martínez
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Risk ,0301 basic medicine ,medicine.medical_specialty ,Chemokine ,Population ,Vascular Cell Adhesion Molecule-1 ,Inflammation ,030204 cardiovascular system & hematology ,Gastroenterology ,Body Mass Index ,03 medical and health sciences ,chemistry.chemical_compound ,Lycopene ,0302 clinical medicine ,Solanum lycopersicum ,Functional Food ,Internal medicine ,medicine ,Humans ,Obesity ,Intervention trial ,education ,Carotenoid ,Aged ,chemistry.chemical_classification ,education.field_of_study ,Cross-Over Studies ,030109 nutrition & dietetics ,biology ,Anti-Inflammatory Agents, Non-Steroidal ,Stereoisomerism ,Middle Aged ,Atherosclerosis ,Intercellular Adhesion Molecule-1 ,Carotenoids ,Inflammatory biomarkers ,Surgery ,Fruit and Vegetable Juices ,chemistry ,Spain ,Human plasma ,biology.protein ,Inflammation Mediators ,medicine.symptom ,Biomarkers ,Follow-Up Studies ,Food Science ,Biotechnology - Abstract
cope : To evaluate the effects of carotenoids from tomato juice (TJ) on inflammatory biomarkers, by performing a 4-week dose-response nutritional trial in a population at high cardiovascular risk. Methods and results : An open, prospective, randomized, cross-over, and controlledclinical trial was carried out with 28 volunteers (mean age 69.7 ± 3.1 years; mean BMI 31.5 ± 3.6 kg/m2) at high cardiovascular risk, which were assigned to consume daily for 4 weeks in random order: 200 mL (LD) or 400 mL (HD) of TJ, or water as a control (C), with a 21-day wash-out period between each intervention. Blood samples were collected at baseline (B) and after each intervention. Endpoints included significant changes in plasmatic carotenoids, and adhesion molecules ICAM-1, and VCAM-1, as well as a tendency to decrease the chemokine IL-8. Compared to C, concentration of ICAM-1, and VCAM-1 were significantly lower (p ˂ 0.001), after each TJ intervention. Decreases were correlated remarkably with the trans-lycopene, while the other carotenoids present in TJ have presented a minor association or no association with changes in these molecules. Conclusion : trans-Lycopene from TJ may attenuate the risk of CVD by reducing the concentration of important inflammatory molecules related to atherosclerosis. This article is protected by copyright. All rights reserved
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- 2017
28. Urinary 1H Nuclear Magnetic Resonance Metabolomic Fingerprinting Reveals Biomarkers of Pulse Consumption Related to Energy-Metabolism Modulation in a Subcohort from the PREDIMED study
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Ramon Estruch, Cristina Andres-Lacueva, Francisco Madrid-Gambin, Enrique Almanza-Aguilera, D. Corella, Rafael Llorach, Rosa Vázquez-Fresno, Mireia Urpi-Sarda, and Mar Garcia-Aloy
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0301 basic medicine ,030109 nutrition & dietetics ,Pulse (signal processing) ,Nutritional epidemiology ,Urinary system ,Llegums ,Biochemical markers ,General Chemistry ,Urine ,Stepwise regression ,Biology ,Metabòlits ,Orina ,Legumes ,Biochemistry ,Predimed ,Ressonància magnètica nuclear ,Nuclear magnetic resonance ,03 medical and health sciences ,Metabolomics ,Marcadors bioquímics ,Metabolome ,Metabolites - Abstract
Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils and beans), spot urine samples from a subcohort from the PREDIMED study were stratified, using a validated food frequency questionnaire. Non-pulse consumers (≤ 4 g/day of pulse intake) and habitual pulse consumers (≥ 25 g/day of pulse intake) were analysed using a 1H-NMR metabolomics approach combined with multi- and univariate data analysis. Pulse consumption showed differences through 16 metabolites coming from (i) choline metabolism, (ii) protein-related compounds, and (iii) energy metabolism (including lower urinary glucose). Stepwise logistic regression analysis was applied to design a combined model of pulse exposure, which resulted in glutamine, dimethylamine and 3-methylhistidine. This model was evaluated by receiver operating characteristic curve (AUC > 90% in both training and validation sets). The application of NMR-based metabolomics to pulse exposure highlighted new candidates for biomarkers of pulse consumption, the role of choline metabolism and the impact on energy metabolism, generating new hypotheses on energy modulation. Further intervention studies will confirm these findings.
29. Caracterización fisicoquímica de vinos tinto Malbec con diferente tiempo de añejamiento
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Juan José Figueroa González, Enrique Almanza Aguilera, María Dolores Alvarado Nava, Salvador Horacio Guzmán Maldonado, and María Guadalupe Herrera Hernández
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Almacén ,calidad enológica ,vino ,Agrociencias ,ambiente ,General Medicine - Abstract
El Campo Experimental Zacatecas (INIFAP) históricamente ha producido y almacenado vinos de sus viñedos; sin embargo, no se conoce su calidad enológica de estos vinos. En 2011 se evaluó la calidad de catorce vinos tintos Malbec producidos de 1976 a 2009 en este Campo. A las muestras se les determinó la acidez total y volátil, pH, contenido de alcohol, extracto seco, sólidos precipitados, pigmentos monoméricos y poliméricos y el color CIELAB. Las características fisicoquímicas de los vinos producidos en 1980, 1985 y 2009 estuvieron dentro del rango recomendado por la industria vinatera. Los datos sugieren que tanto las temperaturas máxima (~22 oC) y minima (~7 oC) así como la precipitación media del estado (22.9-29.7 mm) afectaron positivamente las características del vino. Por otro lado, varias muestras presentaron altos niveles de acidez volátil que sugiere contaminaciones por acetobacterias. Los vinos con un pH alto presentaron un color de mala calidad para un vino tinto. Se encontró una correlación significativa (r= 0.63, p< 0.05) entre los pigmentos poliméricos pequeños y el tiempo de añejamiento lo cual afectó el color del vino con excepción de las muestras producidas en 1980, 1985 y 2009. Dada las características enológicas de algunos vinos, es posible llevar a cabo su comercialización. Es importante llevar a cabo la caracterización química, aceptación sensorial y evaluar el efecto del ambiente sobre la calidad de los vinos producidos en Zacatecas.
30. ESTUDIO COMPARATIVO DE CARACTERÍSTICAS DE CALIDAD ENTRE GENOTIPOS DE FRIJOL DE GRANO NEGRO
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Israel Guzmán Tovar, Enrique Almanza Aguilera, Jorge A. Acosta-Gallegos, and Salvador Horacio Guzmán Maldonado
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Limpieza ,uniformidad ,Agrociencias ,espesor de caldo ,sabor - Abstract
El frijol negro de importación sembrado en México son conocidos como Negro Michigan. No se sabe cuales son las características que lo hacen competir ventajosamente con las variedades locales de frijol. Se realizaron encuestas a productores, comercializadores y consumidores del centro del país, para obtener un panorama de la situación entre las variedades locales de frijol negro y la de importación. Por otro lado, se determinaron las características físicas de la materia extraña, tamaño, color, peso, contenido y grosor de testa a variedades comerciales y líneas de frijol negro de México y Negro Michigan y T39. Asimismo, se determinó la capacidad de absorción de agua, sólidos lixiviados y espesor del caldo. El sabor fue importante para 41% de los consumidores. Debe mejorarse la apariencia física del grano de las variedades locales de frijol negro que se comercializan en la región para que puedan competir con la variedad importada. Los estudios de aceptación sensorial durante el desarrollo de una nueva variedad de frijol negro son importantes. Entre las líneas de frijol evaluadas algunas fueron muy similares en características de calidad a la variedad Negro Michigan y deben ser registradas como variedades ya que al estar adaptadas a las condiciones locales pueden competir ventajosamente en el mercado nacional con base en su productividad y calidad.
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