Back to Search Start Over

Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus

Authors :
Enrique Almanza-Aguilera
Álvaro Hernáez
Dolores Corella
Albert Sanllorente
Emilio Ros
Olga Portolés
Julieta Valussi
Ramon Estruch
Oscar Coltell
Isaac Subirana
Silvia Canudas
Cristina Razquin
Gemma Blanchart
Lara Nonell
Montserrat Fitó
Olga Castañer
Source :
Journal of Clinical Medicine, Vol 10, Iss 1, p 85 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini–Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant “upregulation” and ≤ −2.0 “downregulation”). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, −log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, −log(p-value) = 2.03) and paxillin (z-score = 2.33, −log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = −2.14, −log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.

Details

Language :
English
ISSN :
20770383
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.404feb24ce684996ba0a45c8348284dc
Document Type :
article
Full Text :
https://doi.org/10.3390/jcm10010085