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1. Dynamic Soluble IL-6R/Soluble gp130 Ratio as a Potential Indicator for the Prostate Malignancy Phenotype—A Multicenter Case–Control Study.

Author

Ene, Cosmin-Victor, Geavlete, Bogdan, Mares, Cristian, Nicolae, Ilinca, and Ene, Corina Daniela

Subjects
*ACUTE phase proteins, *ACUTE phase reaction, *PROSTATE tumors, *SERUM albumin, *TRANSFERRIN, *PROSTATE cancer
Abstract

Objective: Prostate tumors, if prostate cancer or adenoma, represent a major public health challenge. Progress in research on inflammation has revealed a connection between inflammation, immunity, and cancer. In this context, this study aimed to find IL-6 signaling systemic abnormalities in the inflammatory tumor microenvironment. Material and methods: This study was case–controlled, multicentered, and included 86 patients, 43 diagnosed with BPH and 43 diagnosed with PCa, between January 2019 and January 2020. The study group was homogenous and the studied parameters were IL-6 complex (IL-6, soluble receptor IL-6R, soluble glycoprotein gp130), acute phase proteins (C reactive protein—CRP, acid alpha1 glycoprotein—AGPA, ferritin, albumin, transferrin), and oxidative stress-associated variables (malondialdehyde—MDA, carbonylated protein—PCO, 8-hydroxy-deoxy guanosine-8-OHdG, total antioxidant status—bTAS). Results: The inflammatory microenvironment determined IL-6 signaling alterations (over-regulation of sIL-6R and suppression of sgp130 in PCa versus BPH), changes in acute phase reaction markers (increased serum levels of CRP, AGPA, ferritin, and decreased serum levels of albumin, transferrin) that were much more evident in PCa compared to BPH, an imbalance between macromolecular oxidative damage (MDA, PCO, 8-OHdG) and endogenous antioxidants (TAS) that was more accentuated in PCa compared with BPH, and a representative association between the sIL-6R/sgp130 ratio and inflammatory/oxidative stress-related factors only in PCa patients. Conclusions: Our study reconfirms the anterior concept that IL-6 promotes prostatic tumorigenesis. In this study, we first demonstrated that a high sIL-6R/sgp130 ratio facilitates prostate malignancy. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Large Symptomatic Inguinoscrotal Seroma Occurred Early after Laparoscopic Total Extraperitoneal Hernia Repair (TEP): a Case Report and Literature Review

Author

UNGUREANU, Claudiu-Octavian, primary, STANCULEA, Floris, additional, GINGHINA, Octav, additional, ENE, Cosmin, additional, STOICA, Andrei, additional, GEAVLETE, Bogdan, additional, CRISTIAN, Daniel Alin, additional, GRIGOREAN, Valentin Titus, additional, GEAVLETE, Petrisor, additional, and IORDACHE, Niculae, additional

Published
2024
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3. Update on Urinary Tract Infection Antibiotic Resistance—A Retrospective Study in Females in Conjunction with Clinical Data

Author

Mareș, Cristian, primary, Petca, Răzvan-Cosmin, additional, Popescu, Răzvan-Ionuț, additional, Petca, Aida, additional, Mulțescu, Răzvan, additional, Bulai, Cătălin Andrei, additional, Ene, Cosmin Victor, additional, Geavlete, Petrișor Aurelian, additional, Geavlete, Bogdan Florin, additional, and Jinga, Viorel, additional

Published
2024
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4. Double J Stents and Reno–Ureteral Lithiasis: Dynamic Changes in Management during the COVID-19 Pandemic

Author

Militaru, Adrian, primary, Bulai, Catalin Andrei, additional, Ene, Cosmin, additional, Popescu, Razvan Ionut, additional, Cozma, Cosmin, additional, Mares, Cristian, additional, Balacescu, Stefan, additional, Moldoveanu, Cristian, additional, Georgescu, Dragos Adrian, additional, Geavlete, Petrisor Aurelian, additional, and Geavlete, Bogdan Florin, additional

Published
2023
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5. LaterPay: Micro Payment

Author

Ene, Cosmin, Burgmaier, Stefanie, Section editor, Hüthig, Stefanie, Series editor, Tiberius, Victor, editor, and Rasche, Christoph, editor

Published
2017
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6. Changes in Serum IL-12 Levels following the Administration of H1-Antihistamines in Patients with Chronic Spontaneous Urticaria.

Author

Ene, Corina Daniela, Tocut, Milena, Tampa, Mircea, Georgescu, Simona Roxana, Matei, Clara, Leulescu, Iulia Maria Teodora, Nicolae, Ilinca, and Ene, Cosmin

Subjects
URTICARIA, DISEASE duration, CELLULAR signal transduction, DISEASE complications, INFLAMMATION, IMMUNE response
Abstract

Introduction. Research regarding the role of the IL-12 cytokine family in modulating immune and inflammatory responses is continuously evolving. In this study, the contribution of the p35 and p40 subunits as monomers (noted as IL-12p35 and IL-12p40) and heterodimers (noted as IL-12p70 or IL-12p35/p40) was analysed in the pathophysiology and progression of chronic spontaneous urticaria (CSU). Materials and methods. We conducted a longitudinal, case–control study involving 42 CSU cases and 40 control cases comprising adults without associated conditions. Serial measurements were performed to assess the serum levels of IL-12p70, IL-12p35, and IL-12p40 at the onset of the disease (pre-therapy phase) and 6 weeks after the initiation of the treatment (post-therapy phase). Results. During the pre-therapeutic phase of CSU, elevated serum levels of IL-12 cytokine subtypes were detected compared to the control group. The relationship between IL-12 profiles and the course of CSU highlighted the pro-inflammatory role of IL-12p70 and the anti-inflammatory role of IL-12p35. Significant correlations were observed between IL-12p70 levels and the duration of the disease, as well as between IL-12 and the effectiveness of H1-antihistamines. Conclusions. The molecular background for the pleiotropic activities mediated by IL-12-derived cytokines in patients with CSU lies in the strict regulation of the production, signalling pathways, and cytokine-specific influences on the same pathophysiological events. The results of the present study suggest that the superficial layers of the skin serve as a cellular source of IL-12, a cytokine produced through antigenic stimulation. In patients with CSU, we identified independent, additive, or divergent functions of IL-12p70, IL-12p35, and IL-12p40, all relevant to systemic inflammation. These findings prove that the prototype programming of IL-12 is abnormal in CSU. [ABSTRACT FROM AUTHOR]

Published
2024
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8. New Insights into Lynch Syndrome: A Narrative Review.

Author

Ene, Cosmin Victor, Bulai, Catalin Andrei, Geavlete, Petrisor, Popescu, Razvan Ionut, Vacaroiu, Ileana Adela, Georgescu, Dragoș Eugen, Isaconi, Isabela Voichita, Munteanu, Madalina Andreea, Ene, Corina Daniela, Militaru, Adrian, Geavlete, Bogdan, and Multescu, Razvan

Published
2023
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10. Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

van der Heijden, Antoine G., Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan J., van Rijt-van de Westerlo, Cindy C. M., Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin P., Czerniak, Bogdan, Schalken, Jack A., Kiemeney, Lambertus A. L. M., Ribal, Maria J., Witjes, J. Alfred, and Alcaraz, Antonio

Published
2018
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11. Chronic Kidney Disease—An Underestimated Risk Factor for Antimicrobial Resistance in Patients with Urinary Tract Infections

Author

Vacaroiu, Ileana Adela, primary, Cuiban, Elena, additional, Geavlete, Bogdan Florin, additional, Gheorghita, Valeriu, additional, David, Cristiana, additional, Ene, Cosmin Victor, additional, Bulai, Catalin, additional, Lupusoru, Gabriela Elena, additional, Lupusoru, Mircea, additional, Balcangiu-Stroescu, Andra Elena, additional, Feier, Larisa Florina, additional, Simion, Ioana Sorina, additional, and Radulescu, Daniela, additional

Published
2022
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12. The effectiveness of citrates and pyridoxine in the treatment of kidney stones.

Author

Andrei Ene, Mihai, Aurelian Geavlete, Petrisșor, Elena Simeanu, Cătălina, Andrei Bulai, Cătălin, Victor Ene, Cosmin, and Florin Geavlete, Bogdan

Abstract

The prevalence of nephrolithiasis is increasing across all demographic groups. Apart from the morbidity associated with an acute occurrence, preventative treatment is essential for stone disease, which can become a long-term problem. Simple interventions like fluid intake optimization and dietary modification are effective for most stone types. However, patients with specific metabolic abnormalities may require pharmaceutical therapy if lifestyle changes are insufficient to reduce the risk of stone recurrence. The treatment of citrates and/or pyridoxines may help eliminate or prevent recurrences of kidney stones, especially when they are composed of uric acid, calcium oxalate, calcium phosphate, or the latter two together. In cases of struvite stones, which often necessitate a surgical approach, acetohydroxamic acid emerges as a valuable second-line treatment option. Thiol-binding agents may be needed for cystinuria, as well as lifestyle modifications. Successful treatment reduces stone recurrence and the need to remove stones surgically. [ABSTRACT FROM AUTHOR]

Published
2023
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13. STONE FREE-RATE EXPERIENCE IN POST-INTERVENTIONAL PATIENTS UNDERGOING CITRATES AND PYRIDOXINE ADMINISTRATION.

Author

ENE, MIHAI ANDREI, JINGA, VIOREL, GEAVLETE, PETRIȘOR AURELIAN, ENE, COSMIN VICTOR, BULAI, CĂTĂLIN ANDREI, SERBOIU, CRENGUTA SORINA, and GEAVLETE, BOGDAN FLORIN

Subjects
LASER lithotripsy, VITAMIN B6, CITRATES, KIDNEY stones, LOW-protein diet, PATIENTS' attitudes
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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15. Unfavorable factors in accessing the pelvicalyceal system during retrograde flexible ureteroscopy (fURS).

Author

Geavlete, Bogdan, Mareș, Cristian, Popescu, Răzvan-Ionuț, Mulțescu, Răzvan, Ene, Cosmin, and Geavlete, Petrișor

Subjects
URETEROSCOPY, FIBER lasers, FUR, ENDOSCOPES, KIDNEYS, CONGENITAL disorders
Abstract

Flexible ureteroscopy (fURS) is a well-established procedure for treating multiple upper-urinary tract pathologies, particularly renoureteral lithiasis. Endoscopes have undergone significant advancements, including miniaturization, improved optics, and increased maneuverability. In addition, advancements in accessory instruments, such as the performance of laser fibers, guidewires, and extraction probes, have played a significant role in improving the overall performance of flexible ureteroscopy procedures. However, despite these advancements, unique circumstances can make achieving optimum results during flexible ureteroscopy challenging. These include congenital renal anomalies (horseshoe kidneys, ectopic kidneys, rotation anomalies), as well as the unique intrarenal anatomy (infundibulopelvic angle, infundibular length) or the specifications of the endoscope in terms of maneuverability (active and passive deflection). This review explored challenging scenarios during flexible ureteroscopy procedures in the pyelocaliceal system. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Single-use versus conventional reusable flexible ureteroscopes - an evaluation of the functional parameters.

Author

Bragaru, Marius, Multescu, Razvan, Georgescu, Dragos, Bulai, Cătălin, Ene, Cosmin, Popescu, Razvan, Geavlete, Petrişor, and Geavlete, Bogdan

Subjects
URINARY calculi, EXTRACORPOREAL shock wave lithotripsy, KIDNEY stones
Abstract

The purpose of single-use flexible ureteroscopes (su-fURS) was to overcome the limitations of conventional reusable ureteroscopes in terms of maneuverability and maintenance. We aimed to perform a systematic literature review on available su-fURS performance versus conventional reusable fURS focusing on clinical data. A systematic research using Pubmed was performed evaluating single-use fURS and reusable fURS in urinary tract stone disease, including prospective assessments and case series. This review aimed to provide an overview of single-use and disposable flexible ureteroscopes and to examine and compare their capabilities (deflection, irrigation, optical properties). We included 11 studies, where the single-use fURS were compared to the reusable fURS. The studies with single-use ureteroscopes included data on LithoVue (Boston Scientific), The Uscope UE3022 (Pusen, Zhuhai, China), NeoFlex-Flexible, (Neoscope Inc San Jose, CA), 23 YC-FR-A (Shaogang). For reusable ureteroscopes, data were included on three models, two digital (Karl Storz Flex-XC and Olympus URF-Vo) and one fiber optic (Wolf-Cobra). There were no significant differences in stone-free rate, procedure duration, or functional capabilities between single-use fURS and reusable fURS. The systematic literature review analyzed operative time, functional capabilities, stone-free rates, and postoperative complications of the ureteroscopes, and a special chapter about renal abnormalities to emphasize that they are a good choice having a high proportion of stone-free rates and few risks, particularly in treating difficult-to-access calculi. Single-use fURS demonstrate a comparable efficacy with reusable fURS in resolving renal lithiasis. Further studies on clinical efficacy are needed to determine whether single-use fURS will reliably replace its reusable counterpart. [ABSTRACT FROM AUTHOR]

Published
2023
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18. COMPARISON OF STONE-FREE RATE WITH CITRATURIA LEVELS IN KIDNEY STONES TREATED WITH DIGITAL FLEXIBLE URETEROSCOPY WITH HOLMIUM LASER LITHOTRIPSY.

Author

ENE, MIHAI ANDREI, GEAVLETE, PETRIȘOR AURELIAN, BULAI, CĂTĂLIN ANDREI, ENE, COSMIN VICTOR, and GEAVLETE, BOGDAN FLORIN

Subjects
LASER lithotripsy, KIDNEY stones, HOLMIUM, URETEROSCOPY, CITRATES
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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23. Additional file 8: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Abstract

Figure S5. Flow diagram of participants in the cross-sectional study according a) to the three-gene methylation classifier and cytology results and b) to the combined three-gene methylation/cytology classifier. Abbreviations: R-PFBC, recurrent patients in follow-up for bladder cancer; NR-PFBC, non-recurrent patients in follow-up for bladder cancer; Cytol, cytology; NA, non-available; Test, combined three-gene methylation/cytology classifier. (PPTX 85Â kb)

Published
2018
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24. Additional file 3: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Abstract

Figure S2. Pearson correlation coefficient heat map of the percentage of methylation for every CpG dinucleotide in the seven genes. Every CpG sites are correlated (via the Pearson correlation) with all others. Correlations are scaled by the color of the corresponding cell. Parameters are represented in the same order on the x- and y-axes. (PPTX 1232Â kb)

Published
2018
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25. Additional file 7: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Abstract

Figure S4. Sensitivity, negative and positive predictive values of urine cytology, the three-gene methylation classifier, and the combined three-gene methylation/cytology classifier in the testing set (Nâ =â 308). Overall specificity was 94% for urine cytology, 27% for the three-gene methylation classifier, and 40% for the combined three-gene methylation/cytology classifier. Abbreviations: LG, low-grade; HG, high-grade; NMIBC nHR, non-muscle-invasive bladder cancer non-high risk; NMIBC HR, non-muscle-invasive bladder cancer high risk; NPV, negative predictive value; PPV, positive predictive value. (PPTX 189Â kb)

Published
2018
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26. Additional file 5: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Abstract

Table S2. Percentage of methylation for each CpG dinucleotide in the seven selected genes in control and bladder cancer urine samples. Underlined in grey the CpG site used for methylation analysis. Abbreviations: SDV; Standard Deviation. (DOCX 21Â kb)

Published
2018
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27. Additional file 6: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Abstract

Table S3. Diagnostic performance of the three-gene methylation classifier, cytology, and the combined methylation/cytology classifier in the training and testing subset of samples with cytology available. Abbreviations: LG, Low Grade; HG, High Grade; AUC, area under curve; MIBC, muscle invasive bladder cancer; NMIBC, Non-Muscle Invasive Bladder Cancer; NPV, Negative Predictive Value; PPV, Positive Predictive Value; SN, Sensitivity; SP, Specificity; BC, Bladder Cancer; C, Control; R-PFBC, Recurrent Patients in Follow up for Bladder Cancer; NR-PFBC, Non Recurrent Patients in Follow up for Bladder Cancer. (DOCX 20Â kb)

Published
2018
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28. Additional file 2: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Abstract

Table S1. Primer sequences used in PCR and pyrosequencing. (DOCX 13Â kb)

Published
2018
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29. Additional file 9: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Subjects
fungi
Abstract

Figure S6. DNA methylation profiles for bladder cancer and control tissue samples for the three-gene classifier. Data obtained from Wanderer Web page: http://maplab.imppc.org/wanderer/ . The red arrow indicates the CpG dinucleotide analyzed in each of the three genes. (PPTX 203Â kb)

Published
2018
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30. Additional file 4: of Urine cell-based DNA methylation classifier for monitoring bladder cancer

Author

Heijden, Antoine Van Der, Mengual, Lourdes, Ingelmo-Torres, Mercedes, Lozano, Juan, Westerlo, Cindy Van Rijt-Van De, Baixauli, Montserrat, Geavlete, Bogdan, Moldoveanud, Cristian, Ene, Cosmin, Dinney, Colin, Czerniak, Bogdan, Schalken, Jack, Kiemeney, Lambertus, Ribal, Maria, J. Witjes, and Alcaraz, Antonio

Abstract

Figure S3. Representative pyrograms showing gene methylation patterns in DNA urine samples from a bladder cancer patient. Percentage of methylation is indicated above peaks (gray columns) corresponding to the CpG sites in this region. (PPTX 183Â kb)

Published
2018
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31. MP45-19 A LONG-TERM, PROSPECTIVE, RANDOMIZED-CONTROLLED COMPARISON OF SURGICAL SAFETY AND CLINICAL EFFICIENCY IN MEDIUM SIZE BPH CASES – THE EVIDENCE-BASED 8 YEARS’ TEST OF TIME FOR THE MONO- AND BIPOLAR TURP VERSUS THE BIPOLAR PLASMA VAPORIZATION

Author

Geavlete*, Bogdan, primary, Georgescu, Dragos, additional, Multescu, Razvan, additional, Bulai, Catalin, additional, Ene, Cosmin, additional, Balan, Georgiana, additional, Ene, Andrei, additional, and Geavlete, Petrisor, additional

Published
2019
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33. Actualities In The Diagnosis and Treatment Of Prostatitis.

Author

Ene, Cosmin Victor, Geavlete, Petrisor, Bulai, Catalin, Georgescu, Dragos, Ene, Corina Daniela, and Geavlete, Bogdan

Subjects
PROSTATITIS, PROSTATE, PROSTATE biopsy, DIAGNOSIS, THERAPEUTICS, SEXUAL dysfunction
Abstract

Copyright of Romanian Journal of Urology is the property of Romanian Journal of Urology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

39. Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris.

Author

Nicolae, Ilinca, Tampa, Mircea, Ene, Corina Daniela, Mitran, Cristina Iulia, Mitran, Madalina Irina, Sarbu, Maria Isabela, Matei, Clara, Ene, Cosmin, and Georgescu, Simona Roxana

Subjects
URIC acid, KIDNEY diseases, POPULATION-based case control, INVERSE relationships (Mathematics), ALBUMINS, GLOMERULAR filtration rate
Abstract

Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=−0.301 and P=0.036, r=−0.384 and P=0.002). Thus, severe psoriasis is a risk factor for the development of renal disease. [ABSTRACT FROM AUTHOR]

Published
2019

40. Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study.

Author

Ene, Cosmin, Nicolae, Ilinca, and Ene, Corina Daniela

Subjects
*PROSTATE cancer, *VASCULAR endothelial growth factors, *FIBROBLAST growth factors, *PROSTATE, *BENIGN prostatic hyperplasia, *HYPOXIA-inducible factors
Abstract

The present paper aimed to investigate the altered angiogenetic mechanisms in hypoxic conditions in patients with prostate tumours, in correlation with common clinicopathologic variables. A case-control study was developed and included 87 patients with prostate tumours [40 diagnosed with benign prostatic hyperplasia (BPH) and 47 diagnosed with prostate cancer (PCa), using prostate transrectal biopsy] and 40 healthy subjects. The following parameters were evaluated in the serum of volunteers: Hypoxia-inducible factor (HIF)-1α, fibroblast growth factor (FGF)-2, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and -9, thrombospondin (TSP)-1 and soluble VEGF-1 receptor. Experimental data analysis demonstrated increasing amounts of inflammation in patients with PCa (IL-6, 18.1±4.7 ng/ml) and BPH (IL-6, 16.3±5.1 ng/ml) vs. control (IL-6, 4.1±1.2 ng/ml); overregulation of HIF1α in patients with PCa (129.3±21.8 ng/ml) compared with patients with BPH (65.6±18.2 ng/ml) and control (61.3±12.7 ng/ml); angiogenesis abnormalities in patients with PCa (upregulation of FGF-2, VEGF, MMP-2 and -9, suppression of TSP-1 and soluble VEGR-1) and BPH (upregulation FGF-2 and VEGF) compared with the control group. In conclusion, a greater understanding of the biological mechanism, the pathological roles and the clinical significance of various proangiogenic parameters and angiogenic-suppressor proteins seem useful in clinical practice for establishing an early diagnosis of prostate pathology and finding an individualized therapeutic approach. [ABSTRACT FROM AUTHOR]

Published
2023
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41. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

Author

Niculae, Cristian-Mihail, primary, Manea, Eliza, additional, Jipa, Raluca, additional, Merisor, Simona, additional, Moroti, Ruxandra, additional, Benea, Serban, additional, Hristea, Adriana, additional, Neguț, Alina Cristina, additional, Săndulescu, Oana, additional, Streinu-Cercel, Anca, additional, Mărculescu, Dana, additional, Andrei, Magdalena Lorena, additional, Ilie, Veronica, additional, Popa, Marcela, additional, Bleotu, Coralia, additional, Chifiriuc, Carmen, additional, Popa, Mircea Ioan, additional, Streinu-Cercel, Adrian, additional, Orfanu, Alina, additional, Popescu, Cristina, additional, Leuștean, Anca, additional, Catană, Remulus, additional, Negru, Anca, additional, Badea, Alexandra, additional, Orfanu, Radu, additional, Tilișcan, Cătălin, additional, Aramă, Victoria, additional, Aramă, Ştefan Sorin, additional, Vișan, Constanța-Angelica, additional, Drăgănescu, Anca-Cristina, additional, Bilașco, Anuța, additional, Kouris, Camelia, additional, Merișescu, Mădălina, additional, Vasile, Magdalena, additional, Slavu, Diana-Maria, additional, Vintilă, Sabina, additional, Osman, Endis, additional, Oprea, Alina, additional, Sandu, Sabina, additional, Luminos, Monica, additional, Leuştean, Anca, additional, Popescu, Gabriel Adrian, additional, Stanculete, Ramona Georgiana, additional, Enoiu, Ana Vaduva, additional, Marinescu, Adelina Raluca, additional, Lazureanu, Voichita, additional, Marinescu, Adelina-Raluca, additional, Crișan, Alexandru, additional, Lăzureanu, Voichița, additional, Musta, Virgil, additional, Nicolescu, Narcisa, additional, Laza, Ruxandra, additional, Negru, Anca-Ruxandra, additional, Munteanu, Daniela-Ioana, additional, Mihăilescu, Raluca, additional, Dorobăț, Olga, additional, Rafila, Alexandru, additional, Căpraru, Emilia, additional, Niculescu, Marius, additional, Marinescu, Rodica, additional, Lupescu, Olivera, additional, Predescu, Vlad, additional, Tălăpan, Daniela, additional, Popescu, Ramona Ștefania, additional, Bradu, Luminița, additional, Florea, Dragoș, additional, Leca, Daniela Anicuta, additional, Bunea, Elena, additional, Teodor, Andra, additional, Miftode, Egidia, additional, Jugulete, Gheorghiță, additional, Dobrotă, Anamaria, additional, Ilie, Adina, additional, Preoțescu, Liliana Lucia, additional, Irimescu, Nicoleta, additional, Panait, Irina, additional, Niculae, Cristian, additional, Gavriliu, Liana Cătălina, additional, Benea, Otilia Elisabeta, additional, Benea, Șerban, additional, Popoiu, Mona, additional, Dragonu, Livia, additional, Cupşa, Augustin, additional, Diaconescu, Iulian, additional, Niculescu, Irina, additional, Giubelan, Lucian, additional, Dumitrescu, Florentina, additional, Stoian, Andreea Cristina, additional, Guţă, Camelia, additional, Puiu, Simona, additional, Irina, Bunescu, additional, Vallée, Marilyse, additional, Huletsky, Ann, additional, Boudreau, Dominique K., additional, Bérubé, Ève, additional, Giroux, Richard, additional, Longtin, Jean, additional, Longtin, Yves, additional, Bergeron, Michel G., additional, Roșculeț, Cleo Nicoleta, additional, Toma, Dalila-Ana, additional, Ciuca, Catrinel, additional, Apostolescu, Cătălin, additional, Rogoz, Andrei, additional, Stangaciu, Andrei, additional, Mitescu, Viorica, additional, Vladoiu, Tudor, additional, Iovănescu, Doina, additional, Oana, Michaela, additional, Costin, Simona, additional, Moțoi, Maria Magdalena, additional, Dorobăț, Olga Mihaela, additional, Mihai, Alexandru, additional, Roşculeț, Cleo, additional, Popescu, Gabriel-Adrian, additional, Abagiu, Adrian, additional, Moroti-Constantinescu, Ruxandra, additional, Benea, Otilia, additional, Simoiu, Mădălina, additional, Bacruban, Rodica, additional, Bădicuț, Ioana, additional, Borcan, Alina, additional, Hurmuzache, Mihnea, additional, Enache, Georgiana, additional, Ciocan, Alexandra, additional, Bararu, Mircea, additional, Popazu, Madalina, additional, Iovănescu, Doina Viorica, additional, Apostolescu, Cătălin Gabriel, additional, Toma, Dalila, additional, Iliescu, Laura, additional, Minzala, Georgiana, additional, Toma, Letitia, additional, Baciu, Mihaela, additional, Tanase, Alina, additional, Orban, Carmen, additional, Pantea, Victor, additional, Placinta, Gheorghe, additional, Cebotarescu, Valentin, additional, Cojuhari, Lilia, additional, Jimbei, Paulina, additional, Dragomirescu, Cristina, additional, Murariu, Cristina, additional, Stratan, Laurențiu, additional, Munteanu, Daniela, additional, Năstase, Raluca, additional, Molagic, Violeta, additional, Rădulescu, Mihaela, additional, Diaconu, Ioan, additional, Bodosca, Iulia, additional, Niță, Violeta, additional, Năstase, Raluca Mihaela, additional, Bodoșca, Iulia, additional, Diaconu, Ioan Alexandru, additional, Erturk, Yagmur, additional, Șchiopu, Claudiu Mihai, additional, Tenita, Angelica, additional, Aramă, Ștefan Sorin, additional, Iacob, Simona Alexandra, additional, Iacob, Diana Gabriela, additional, Predescu, Mioara, additional, Mărdărescu, Alexandra, additional, Săndulescu, Mihai, additional, Ciuca, Catrinel Olimpia, additional, Toma, Dalila Ana, additional, Mitu, Cristina Elena, additional, Mitescu, Viorica Daniela, additional, Vladoiu, Tudor Gheorghe, additional, Stoica, Monica Andreea, additional, Manolache, Daniela, additional, Ceapraga, Gabriela Jana, additional, Mircea, Gabriela, additional, Durbală, Ionel, additional, Russu, Irina, additional, Holban, Tiberiu, additional, Pantilimonov, Tatiana, additional, Chiriacov, Galina, additional, Macvovei, Arcadie, additional, Scorohodico, Elena, additional, Dmitriev, Oleg, additional, Costache, Diana Alexandra, additional, Benea, Anca, additional, Benea, Elisabeta, additional, Mitran, Mihai, additional, Georgescu, Carmen, additional, Mitran, Loredana, additional, Vladareanu, Simona, additional, Magirescu, Andreea Ioana, additional, Andreev, Viorica, additional, Nicolau, Cristina, additional, Largu, Alexandra, additional, Dorobat, Carmen, additional, Manciuc, Carmen, additional, Isac, Ina, additional, Șerban, Iulia Gabriela, additional, Resul, Ghiulendan, additional, Marcaș, Consuela, additional, Marincu, Iosif, additional, Poptelecan, Patricia, additional, Trincă, Bogdan, additional, Mitrescu, Sorina, additional, Tudor, Anca, additional, Vlad, Daliborca, additional, Tirnea, Livius, additional, Baydaroglu, Nurcan, additional, Ceapraga, Gabriela, additional, Pagute, Mariana, additional, Dorobăț, Carmen, additional, Diaconu, Ioan-Alexandru, additional, Ion, Daniela, additional, Nichita, Luciana, additional, Diaconu, Alexandra, additional, Duport-Dodot, Irina, additional, Mărdărescu, Mariana, additional, Petre, Cristina, additional, Iancu, Marieta, additional, Ungurianu, Rodica, additional, Cibea, Alina, additional, Drăghicenoiu, Ruxandra, additional, Tudor, Ana Maria, additional, Vlad, Delia, additional, Petrea, Sorin, additional, Matei, Carina, additional, Oțelea, Dan, additional, Crăciun, Carmen, additional, Anghelina, Cristian, additional, Dumea, Elena, additional, Rugină, Sorin, additional, Petcu, Lucian Cristian, additional, Halichidis, Stela, additional, Cambrea, Simona Claudia, additional, Chiriac, Carmen, additional, Bodnar, Nina-Ioana, additional, Zaharia-Kezdi, Iringo-Erzsebet, additional, Gîrbovan, Cristina, additional, Incze, Andrea, additional, Georgescu, Anca Meda, additional, Panaitescu, Eugenia, additional, Cojocaru, Manole, additional, Laurențiu, Vochita, additional, Andreia, Vochita, additional, Radu, Opreanu, additional, Bogdan, Trinca, additional, Ovidiu, Rosca, additional, Iosif, Marincu, additional, Zamfir, Ramona, additional, Angelescu, Alina, additional, Popa, Alena Andreea, additional, Gavriliu, Liana, additional, Popa, Alena-Andreea, additional, Ducu, Georgeta, additional, Camburu, Daniela, additional, Cozma, Alina, additional, Podani, Manuela, additional, Dumitriu, Roxana, additional, Cupșa, Augustin, additional, Ionescu, Loredana, additional, Abagiu, Adrian Octavian, additional, Stoica, Loredana Nicoleta, additional, Blaga, Catrinel, additional, Koulosousas, Archontis, additional, Ștefănescu, Roxana, additional, Atomoaie, Alice, additional, Paraschiv, Florentina, additional, Duna, Florin Matache, additional, Olteanu, Rodica, additional, Ion, Roxana, additional, Zota, Alexandra, additional, Jaballah, Isra Ennour, additional, Mahfoud, Lara, additional, Preda, Georgeta, additional, Constantin, Magda, additional, Nicolae, Ilinca, additional, Ene, Corina Daniela, additional, Mitran, Mădălina Irina, additional, Benea, Vasile, additional, Tampa, Mircea, additional, Georgescu, Simona Roxana, additional, Bodoșca, Iulia Cristina, additional, Aramă, Sorin, additional, Caramăngiu, Iuliana, additional, Rosca, Ovidiu, additional, Cialma, Monica, additional, Opreanu, Radu, additional, Vochita, Laurențiu, additional, Murărescu, Vlad, additional, Palaghiță, Marilena, additional, Camburu, Cornel, additional, Duşan, Irina, additional, Bîrlad, Andreea, additional, Miron, Victor Daniel, additional, Drăgănescu, Anca Cristina, additional, Pițigoi, Daniela, additional, Luminos, Monica Luminița, additional, Șchiopu, Sabina, additional, Vasile, Magda, additional, Ionică, Mihaela, additional, Stăncescu, Adina, additional, Popescu, Cristina Elena, additional, Marin, Luminița, additional, Zaharia, Diana, additional, Dumitrescu, Cristina, additional, Tudor, Lucia, additional, Negulescu, Cristina, additional, Caliman-Sturdza, Olga Adriana, additional, Roșculeț, Cleo, additional, Manu, Bogdana, additional, Vaduva-Enoiu, Ana, additional, Lazureanu, Voichita Elena, additional, Niță, Elena-Violeta, additional, Dumitru, Sînziana, additional, Negru, Anca Ruxandra, additional, Ionescu, Ligia, additional, Ion, Liliana, additional, Neacșu, Marioara, additional, Mitran, Cristina Iulia, additional, Pribac, George Ciprian, additional, Prisca, Mirandolina, additional, Ursoiu, Fulvia, additional, Neamtu, Carmen, additional, Totolici, Bogdan, additional, Cotoraci, Coralia, additional, Ardelean, Aurel, additional, Albu, Simona Elena, additional, Carsote, Mara, additional, Miclăuș, Beatrice, additional, Mihai, Diana, additional, Vasiliu, Cristina, additional, Gorgoi, Corina, additional, Blescun, Amelia, additional, Breaza, Gelu, additional, Vintila, Sabina, additional, Mihai, Felicia, additional, Omer, Meilin, additional, Dragan, Cornel, additional, Pitigoi, Daniela, additional, Ciucu, Mirela, additional, Ionescu, Marius-Dan, additional, Roskanovic, Cristina, additional, Barbu, Valentina, additional, Zamfir, Ramona-Alexandra, additional, Dumitru, Alexandra-Sînziana, additional, Ispas, Viorica, additional, Leahu, Diana Oana, additional, Safta, Cristina Maria, additional, Benea, Mihaela Anca, additional, Munteanu, Octavian, additional, Bohâlțea, Roxana, additional, Trașcă, Livia, additional, Cîrstoiu, Monica, additional, Georgescu, Mădălina, additional, Ivanciuc, Alina Elena, additional, Lazar, Mihaela, additional, Ionescu, Teodora, additional, Cherciu, Carmen Maria, additional, Țecu, Cristina, additional, Mihai, Maria Elena, additional, Nițescu, Maria, additional, Azamfire, Delia, additional, Dumitrescu, Aura, additional, Ianosik, Elena, additional, Leca, Daniela, additional, Duca, Elena, additional, Bejan, Codrina, additional, Ceaușu, Emanoil, additional, Florescu, Simin-Aysel, additional, Popescu, Corneliu, additional, Târdei, Grațiela, additional, Juganariu, Codrina, additional, Lupulescu, Emilia, additional, Rodina, Ligia, additional, Cocuz, Maria Elena, additional, Stoian, Andreea, additional, Ionica, Mihaela, additional, Benea, Otilia-Elisabeta, additional, Sîrbu, Maria-Cristina, additional, Dobrotă, AnaMaria, additional, Duda, Roxana, additional, Dragomirescu, Cristiana Cerasella, additional, Fendrihan, Sergiu, additional, Scortan, Ecaterina, additional, Popescu, Corneliu P., additional, Benea, Șerban N., additional, Petcu, Andra E., additional, Podea, Iuliana A., additional, Jipa, Raluca E., additional, Hrișcă, Raluca M., additional, Nica, Manuela, additional, Merișor, Simona, additional, Nicolae, Cristian M., additional, Florescu, Simin A., additional, Dumitru, Irina M., additional, Moroti, Ruxandra V., additional, Nițescu, Bogdan, additional, Mustaţă, Iulia Monica, additional, Boldeanu, Sorina Claudia, additional, Furtunescu, Florentina, additional, Gheorghe, Mihaela, additional, Slavcovici, Adriana, additional, Tripon, Raluca, additional, Iubu, Roxana, additional, Marcu, Cristian, additional, Sabou, Mihaela, additional, Muntean, Monica, additional, Chiriac, Ion, additional, Tazlavanu, Liviu, additional, Cernat, Roxana, additional, Iringo, Kezdi, additional, Vâță, Andrei, additional, Arbune, Manuela, additional, Moisil, Teodora, additional, Ene, Corina-Daniela, additional, Georgescu, Roxana Simona, additional, Ene, Cosmin-Victor, additional, Ciortea, Marilena, additional, Dulgheru, Lucreția, additional, Luca, Mihaela Cătălina, additional, Harja-Alexa, Ioana-Alina, additional, Nemescu, Roxana, additional, Popazu, Mădălina, additional, Luca, Andrei Ștefan, additional, Bancescu, Gabriela, additional, Dabu, Bogdan, additional, Bancescu, Adrian, additional, Ilie, Adina Elena, additional, Pohrib, Săftica-Mariana, additional, Tache, Maria-Sabina, additional, Iliescu, Ion Aurel, additional, Tecu, Cristina, additional, Mihai, Maria-Elena, additional, Lazăr, Mihaela, additional, Cherciu, Carmen, additional, Ivanciuc, Alina, additional, Paliu, Mirela, additional, Curescu, Manuela, additional, Cerbu, Bianca, additional, Bunescu, Irina, additional, Pasnin, Ana, additional, Semeniuc, Stela, additional, and Popovici, Raisa, additional

Published
2016
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48. EFECTUL INFLAMAŢIEI ASUPRA VALORILOR SERICE ALE ANTIGENULUI SPECIFIC PROSTATIC ÂN PATOLOGIILE FRECVENTE ALE PROSTATEI.

Author

Ene, Cosmin Victor, Ene (Nicolae), Corina, Ceauşu, Emanoil, Ionescu, Petronela, and Nicolae, Ilinca

Subjects
*INFLAMMATION, *BLOOD serum analysis, *ANTIGENS, *FIBRINOGEN, *PROSTATE cancer, *HYPERPLASIA
Abstract

Objective: to assess the relationship between the level of prostate specific antigen and the amount of blood C-reactive protein, of fibrinogen, of ESR and of albumin, in patients with nonbacterial chronic prostatitis, benign prostatic hyperplasia and prostate cancer. Material and method. A prospective study was conducted on a total of 88 patients (32 with nonbacterial chronic prostatitis, 27 with benign prostatic hyperplasia, 29 with adenocarcinoma of the prostate) and 30 healthy volunteers. Results. PSA values were significantly different in patients with benign prostatic hyperplasia (3.85 ± 0.07 ng / ml, p <0.05), and adenocarcinoma of the prostate (8.27 ± 6.18 ng / ml, p <0 05) compared to control (0.9 ± 0.7 ng / ml). Serum PSA is affected by the inflammatory process. The influence of inflammation on the PSA level was realized in obtaining a statistically significant positive correlation between PSA and CRP (chronic prostatitis, benign prostatic hyperplasia, prostate adenocarcinoma), between PSA and fibrinogen (prostate cancer) and a negative association between PSA and albumin (benign prostatic hyperplasia, prostatic adenocarcinoma). Conclusions. PSA values should always be interpreted in the clinical context and of the impact of the inflammatory component in the synthesis of this antigen. [ABSTRACT FROM AUTHOR]

Published
2013

49. Is There a Place for Robotic Inguinal Hernia Repair in the Realm of Laparoscopic and Open Inguinal Hernia Repair? A Narrative Review.

Author

UNGUREANU, Claudiu-Octavian, STANCULEA, Floris, GINGHINA, Octav, ENE, Cosmin, and IORDACHE, Niculae

Subjects
*HERNIA surgery, *INGUINAL hernia, *HERNIA, *QUALITY of life, *LAPAROSCOPIC surgery
Abstract

Introduction: Robotic hernia repair is gaining popularity among general surgeons and has potential benefits; however, there are also several issues, of which the one related to increased cost compared to other procedures is the most important one. Integrating a robotic platform in the hernia territory is a difficult task, and this review attempts to analyze the various implications of using robotic assistance in inguinal hernias. From a hernia surgeon’s perspective, each new addition to hernia procedures is important; therefore, we encompass the advantages and drawbacks of this technology. The final point is obviously improving hernia surgery and quality of life in our patients. [ABSTRACT FROM AUTHOR]

Published
2024
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