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The purpose of this study is to examine the effect of strategic restraint on controversial marketing promotion . Research limitations/implications Research limitations/implications - Research reasoning is limited because the variables are newly studied and we cannot directly assess the causal relationship . Originality/Value - This study is one of the few studies that has examined the relationship between strategic inhibition and controversial marketing . Conclusion - The concept of strategic constraint correlates positively with contentious marketing

The following research aimed to identify the most important requirements of fishermen in the Nile River in Dakahlia Governorate. This research was conducted in the selected centers of the studied governorate. The data of this research were collected using a questionnaire method by personal interview for a simple random sample of fishermen in the Nile River, whose number reached 291 fishermen, representing about 24.3% of the studied centers during January 2021. Frequencies, percentages, relative weight, and correlation coefficient were used as tools for statistical analysis and to extract research results the most important results of this research are summarized as follows: About 85.6% of the sample are individuals who have a high level of total knowledge of hunting methods and laws, and the results indicate that mor than three quarters of the respondents 76.6% of the sample individuals have a high level of overall operational need for fishing methods and laws. The requirements related to social security ranked first with a relative weight of 81.10, followed by requirements related to financing, with a relative weight of 80.9, and the control requirements on the Nile River occupied the third order with a relative weight of 76.58.and, the results indicate that the relative importance of the services provided by the bodies of the Nile River was ranked in descending order as follows: Services related to water bodies' police, services related to fishermen's associations, services related to the Ministry of Environment, services related to the Public Authority for Fish Resources, with a relative weight of 70.69, 57.96,54.23 and 45.33, respectively, and the results indicate that the main reasons for the decline in fish productivity in the Nile are due to the continuous cleansing of dredges. Especially after the dumping of seed in the Nile River, the decrease in the quantity of seed in the fish river due to the lack of fish hatcheries. Contamination of the waters of the Nile River with sewage water, which leads to suffocation of seed, at rates of 100%, 91.1% and 89.7%, respectively.

The research aims to extrapolate the repercussions of the use of expert systems in the work of the external auditor on the quality of audit, as the research problem was that despite the use of these techniques in audit work, there is a problem related to the efficiency and effectiveness of these technological systems used in audit work, the feasibility of their use and the extent of their impact: The quality of the audit process. The researchers adopted the questionnaire as a tool for collecting study data from a community composed of auditors in auditing offices and companies in Iraq, and the auditors of the Iraqi Federal Financial Supervision Bureau. The number of recovered and valid questionnaires reached (100), or 76% of the total number of questionnaires distributed. The researchers concluded several results, the most important of which was that the auditor in auditing offices and companies in Iraq, in addition to the auditor of supervisory bodies, are aware of the positive effects of using expert systems in the work of the external auditor on the quality of audit work. The researchers also concluded many recommendations, the most important of which are: the need for the regulatory authorities, whether in the public sector represented by regulatory bodies, or audit offices and companies, to benefit from these modern technologies, the need for professionals and audit offices to invest in this modern technology, the need to integrate modern technologies related to the accounting profession And auditing the curricula of Iraqi universities, institutes, and colleges

Background: Intestinal nematode parasites of equines have emerged as a pressing and urgent challenge due to their significant impact on the health and performance of these animals worldwide; therefore, implementing a deworming regimen has become vital to keeping a horse's parasite load at an acceptable level. Thus, the current study aimed to estimate the prevalence of nematodes infection , associated risk factors and evaluate the chemotherapeutic efficacy of different anthelmintic drugs by enrolling 195 fecal matter samples of working equines using flotation concentration techniques. Equines treatment were divided into four groups; Group 1 standard treatment (Albendazole orally), Group 2 intervention treatment (Doramectin injection), Group 3 intervention treatment (combination of Albendazole and Doramectin), and Group 4 was left untreated as a positive control. Results: The overall prevalence of intestinal nematode parasites in working equines was 70.25%. The recovered nematodes were Strongylus species, with 87.17% followed by Parascaris equorum 30.76%, and Oxyuris equi was 12.82%. Concerning treatment efficacy, the highest cure rate was among Group 3 (77.14%), followed by Group 2 (68.57%) and Group 1 (40%), but the difference between Groups 2 and 3 is statistically insignificant. Interestingly, the effect of Doramectin injection is highly significant than other, especially for the reduction of Strongylus spp. and Parascaris equorum eggs according to Cohen's D test. Conclusions: Translating such a potent combination of drugs into endemic areas will provide significant support for deworming and control programs against intestinal parasites of equines, especially those in the migratory phase, more than Albendazole alone, which has poor absorption as it requires a full stomach during administration.

Background and Aim: In Egypt, there is a scarcity of recent data on trichinellosis in pigs and humans. Therefore, this study aimed to determine the epidemiological profile and risk factors associated with Trichinella spiralis infection as well as to assess the effectiveness of the trichinoscope and digestion technique in diagnosing trichinellosis. Materials and Methods: Data were collected on 33812 pigs slaughtered during a year at the Al-Basateen abattoir, Cairo Governorate, Egypt. The slaughtered pigs had already been examined by trichinoscope in the abattoir. The diagnostic effectiveness technique was randomly conducted on 170 pork muscle samples, which were examined using the digestion technique. Furthermore, 90 serum samples from high-risk individuals in Qena and Sohag Governorates, Upper Egypt, were analyzed using an enzyme-linked immunosorbent assay. Results: The investigation revealed that the overall prevalence was 1.06% in pigs by trichinoscope. Of the examined 170 samples, 2.35% and 3.35% were found to harbor Trichinella by trichinoscope and artificial digestion, respectively. Trichinella was identified as T. spiralis using a polymerase chain reaction (PCR) technique. A significant relationship was affirmed between the prevalence of trichinellosis and the sex and age of the examined pigs. Likewise, for the first time, there was a considerable seasonal trend in the prevalence of Trichinella with the maximum infection, which was observed during Autumn (1.18%). The prevalence of trichinellosis in humans was 10%, with a significant association with age. Conclusion: Our findings are intended to serve as a starting point for developing effective preventive and control measures for trichinellosis (as application of Hazard Analysis Critical Control Points (HACCP) in pig farms, stop feeding pigs on garbage as well as, preventing illegal slaughter of pigs outside the slaughterhouses). It also fortifies the establishment of the digestion technique because of its high specificity and sensitivity, although it is difficult to apply to a large number of samples.

Atrazine, as an herbicide, is used widely worldwide. Because of its prolonged persistence in the environment and accumulation in the body, atrazine exposure is a potential threat to human health. The present study evaluated the possible protective effects of zinc oxide nanoparticles and vitamin C against atrazine-induced hepatotoxicity in rats. Atrazine administered to rats orally at a dose of 300 mg/kg for 21 days caused liver oxidative stress as it increased malondialdehyde (MDA) formation and decreased reduced glutathione (GSH) contents. Atrazine induced inflammation accompanied by apoptosis via upregulation of hepatic gene expression levels of NF-κB, TNF-α, BAX, and caspase-3 and downregulation of Bcl-2 gene expression levels. Additionally, it disturbed the metabolic activities of cytochrome P450 as it downregulated hepatic gene expression levels of CYP1A1, CYP1B1, CYP2E1. The liver function biomarkers were greatly affected upon atrazine administration, and the serum levels of AST and ALT were significantly increased, while BWG%, albumin, globulins, and total proteins levels were markedly decreased. As a result of the above-mentioned influences of atrazine, histopathological changes in liver tissue were recorded in our findings. The administration of zinc oxide nanoparticles or vitamin C orally at a dose of 10 mg/kg and 200 mg/kg, respectively, for 30 days prior and along with atrazine, could significantly ameliorate the oxidative stress, inflammation, and apoptosis induced by atrazine and regulated the hepatic cytochrome P450 activities. Furthermore, they improved liver function biomarkers and histopathology. In conclusion, our results revealed that zinc oxide nanoparticles and vitamin C supplementations could effectively protect against atrazine-induced hepatotoxicity.

Background: Antibiotic resistance emerged in the pathogens causing urinary tract infections (UTIs) and became widespread. Moreover, increasing drug resistance has highlighted the need to evaluate the antibiotic resistance pattern to improve experimental treatment. The purpose of this study was to evaluate the bacteria causing UTIs and their susceptibility patterns based on the geographical area. Methods: The present study was conducted on outpatients referred to Qal’at Saleh Hospital in Iraq from January 2018 to January 2019. The pathogenic bacteria were detected using API 20E kit. The antimicrobial susceptibility testing was conducted using the disk diffusion method according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI). Results: Of 216 isolates, 87.9% contained gram-negative bacteria and 12.03% contained gram-positive bacteria. In this study, Escherichia coli was identified as the main cause of UTIs. Of all the isolates, 73.61% were resistant to three or more classes of antibiotics. The antibiotic susceptibility and resistance patterns of all isolates showed that amikacin and ciprofloxacin had the highest activity against gram-negative bacteria and vancomycin, amikacin, and levofloxacin had the highest activity against gram-positive bacteria. Conclusions: Due to the widespread resistance to drugs used in the treatment of UTIs, it is difficult to select the appropriate drugs for treating UTIs. UTI affects different age groups; therefore, sufficient knowledge should be transferred to the community to prevent these infections. If urine culture is unavailable, or it is impossible to wait for antibiotic susceptibility testing, Amikacin and Vancomycin might be the best candidates for UTI treatment.

Introduction Older adults with Alzheimer’s disease (AD) experience drastic changes in their physical and mental abilities. AD patients became heavily dependent on their caregivers for everyday functions, which have significant implications not only for them but also for their caregivers. So, many AD caregivers experienced an increased level of depression and anxiety symptoms, lower perceived control, and higher burden compared to non-AD caregivers. Therefore, psychological first aid (PFA) and educational interventions are designed to enable those caregivers to meet the daily requirements of their patient care and to cope with its challenges. Aim Determine the effect of psychological first aid program on stress level and psychological well-being among caregivers of older adults with Alzheimer’s disease. Design One group pre-test post-test was followed. Subjects A convenience sample of one hundred (100) caregivers of older adults with AD. Setting All online groups concerned with the care of Alzheimer’s disease patients on Facebook. Tools Socio-demographic and clinical data of older adults with Alzheimer’s disease and their caregivers’ questionnaire, Alzheimer’s disease knowledge scale, Kingston caregiver stress scale, and authentic identity measures (AIM) scale of psychological well-being Results The psychological first aid program has highly statistically significant effect on the AD caregivers’ knowledge, stress level and psychological well-being as (t=-30.707, P = 0.000, t = 8.500, P = 0.000 & t= -4.763, P = 0.000 respectively). Conclusion Psychological first aid program is considered an effective intervention in decreasing the AD caregivers’ stress and increasing their psychological wellbeing and knowledge regarding delivering care for AD patients.

Background: Stroke is a leading cause of death and disability worldwide. It is a complex disease and medical emergency that requires immediate medical attention, efforts and skills of all members of the multidisciplinary team to minimize brain damage and potential complications especially in the first 24hrs. Aim of the study was to assess the health team's performance in the first 24hrs regarding patients with stroke. Design: An exploratory descriptive study Setting: The study was carried out and conducted in the stroke ICU, neuro-surgical ICU, the emergency and neurosurgery department at Nasr Institute Hospital for research and treatment. Study subjects: A purposive sample consists of 60 nurses and 40 neurologists and ICU physicians their mean age was 34.5±8.28 and36.10±7.94 respectively. Data collection tools: a) health team self-administered questionnaire. b) Health team practice observational checklist, and c) Health team self-administered form (attitude scale). Results & conclusion: Firstly, (sixty, fifty-one & fifty-five) of the nurses under the study had unsatisfactory level of knowledge, practice and had a negative attitude in the first 24 hours regarding patients with stroke respectively. Secondly, (sixty-five, sixty& fifty-five) of the neurologists and ICU physicians under the study had satisfactory level of knowledge, practice and had a positive attitude in the first 24 hours regarding patients with stroke respectively. Furthermore, there was a highly statistically significant relation between nurses' knowledge, practice, attitude and their demographic data. Also, there was a highly statistically significant relation between neurologists and ICU physicians' knowledge, practice, attitude and their demographic data. Recommendation: This study recommends the importance of in- service training courses and designing health team educational program to enhance their knowledge and improve their practices in the first 24hrs regarding patients with stroke and minimize complications after stroke

A couple of natural coumarins was identified in the seeds of two apples’ cultivars commonly known as Granny Smith and Red Delicious. The effect of the phenolic hydroxyl moieties found in these products was evaluated on the bioactivity. This evaluation included the structural alteration of these moieties into less hydrophilic ones to explore the significance of the parent moieties on the biological activity. The investigated biopotentials were antioxidant, antiproliferative, antibacterial, and antifungal effects. The antioxidant potential was investigated by detecting the ability of the natural and semisynthetic coumarins to trap the free hydroxyl and DPPH radicals. The antiproliferative potential was assessed via an MTT-depended assay versus eight cancerous-cell lines, included HeLa, SK-OV-3, AR42J, MCF-7, AB12, KYSE-30, LC540, and AMN3. The antibacterial potential was tested versus six common pathogenic bacterial strains via a well-defined disc diffusion assay. These pathogens were Escherichia coli, Salmonella typhi, Klebsiella pneumonia, Haemophilus influenzae, Shigella dysenteriae, and Pseudomonas aeruginosa. The antifungal potential was also screened by utilizing a similar microbiological technique versus three pathogenic fungi, involved Candida albicans, Aspergillus flavus, and Aspergillus niger. It is concluded that the investigated chemical moiety has a positive influence on the antioxidant and antiproliferative potentials of the natural derivatives, and a negative one on their antibacterial and antifungal potentials.

In the present study, we utilized Stevia rebaudiana L. (SRLe) extract to in situ biosynthesize nanoscale alpha hematite (α-Fe2O3) nanoparticles (NPs) with potent antioxidant, antimicrobial, and anticancer properties. SRLe-α-Fe2O3 was characterized using physiochemical analyses, including UV/Vis, FTIR, XRD, DLS, EDX, SEM, and TEM studies. Among tested solvents, CHCl3/MeOH (2:1 v/v) SRL extract (least polar solvent) contained the highest EY, TPC, and antioxidant capacity of ~3.5%, ~75 mg GAE/g extract, and IC50 = 9.87 ± 0.7 mg/mL, respectively. FTIR confirmed the engagement of coating operation to the colloidal α-Fe2O3 NPs. TEM, SEM, and DLS revealed that SRLe-α-Fe2O3 has a spherical shape, uniform size distribution with aggregation for an average size of ~18.34 nm, and ζ = −19.4 mV, forming a repulsive barrier that helped to improve stability. The synthesized nanoparticles displayed considerable antibacterial activity against E. coli and S. aureus bacterial growth, and exhibited superior activity against the A549 lung cancer cell lines. These findings indicate that the increased availability of bioactive substances with antioxidant properties of SRLe makes it a potentially interesting material for the preparation of biologically active compounds and green synthesis of nanoparticles.

Background and Objectives: Uropathogenic Escherichia coli (UPEC) is divided into different phylogenetic groups that differ in their antibiotic resistance patterns, serogroups and pathogenicity. This study aimed to investigate the prevalence of phylogenetic groups of UPEC isolates and their relationship with serogroups and virulence factors in patients with UTIs. Materials and Methods: Of the 412 urine samples tested a total of 150 UPEC were isolated and confirmed with PCR using 16S rRNA gene. Antibiotic resistance of the isolates was tested using disk diffusion method and the isolates were divided into phylogenetic groups by the quadruplex PCR method. The prevalence of serogroups and virulence genes were investigated using multiplex PCR. Results: 87 (58%) of the isolates belonged to phylogroup B2. Virulence genes fimH (95.3%), aer (49.3%) and serogroups O8 (22.3%), O25 (21.5%) showed the highest prevalence. The lowest drug resistance was observed against imipenem (4.6%) and meropenem (3.3%). The prevalence of multidrug-resistant and extended-spectrum beta-lactamases isolates were 60% and 61.3%, respectively. We also found a significant relationship between phylogenetic groups, serogroups and virulence factors among our isolates. Conclusion: The high abundance of phylogenetic group B2, serogroups O8 and O25, and virulence genes fimH and aer indicate their importance in the pathogenesis of UPEC in this country.

Gastrointestinal nematodes are one of the most important constraints of poor geese health and productivity, in addition to being involved in great economic losses for various poultry sectors. This study primarily aimed at determining the epidemiological profile and risk factors associated with the occurrence of gastrointestinal (GI) nematode parasites in geese in Egypt. The phylogenetic relationships between heterakids were the second aim. For achieving these aims, a total 180 of intestinal samples were screened for the presence of gastrointestinal nematodes over a period of one year from December 2018 to November 2019. Furthermore, A PCR-based DNA sequencing of the mitochondrial NADH dehydrogenase subunit1 gene (nad1) was conducted for characterization of adult Heterakis dispar. The current search revealed that the overall prevalence was 33.33% (60/180). Five species of nematode species was encountered in this study, namely Capillaria spp., Heterakis gallinarum (Schrank, 1788), Ascaridia galli (Schrank, 1788), Subulura brumpti (Lopez-Neyra, 1922) and Heterakis dispar (Schrank, 1790). A positive relationship was found between the prevalence of nematode infection and age of tested geese revealing that the high prevalence was found in adults rather than young birds (P = 0.03). Moreover, there was no significant difference in the prevalence of nematode infection between male and female geese (P > 0.05). Also, there was strong significant seasonal trends in the prevalence of the recovered helminths with the maximum infection was observed in summer season and lowest in winter (P = 0.002). The BLAST analysis of H. dispar nad1 sequence showed a 96.4% similarity with the sequences of H. dispar Heilongjiang. It also showed a lower similarity to the mitochondrial gene sequences of H. gallinarum (84.4%). This is the first molecular identification and report of genetic diversity of Heterakis dispar in geese from Egypt. The current finding initially provides a concise account of knowledge about the epidemiology of gastrointestinal nematodes infecting geese and are considered as a starting point for the implementation of appropriate control and prophylactic schemes for GIT nematodiasis. It also confirms the potential uses of genetic techniques for taxonomic studies of different parasites.

Tigris River is the only potable source in Baghdad city therefor many water treatment plants were built on the banks such as Al-Karkh, Sharq Dijla, Al-Sadr, Al-Wathba, Al-Karama, AlQadisia, Al-Dora, Al-Wahda, and Al-Rashed project. Tigris River suffers from the pollution that comes from various sources such as Industry, domestic sanitation, and farming activities therefore several indices were used to calculate water quality within Baghdad to convert physicochemical parameters of water to a single value that represents the river status (good, bad, very bad, etc..). The aim of this review paper to show the results of previous studies about the water quality for the Baghdad region. Most results showed that water quality was good in the north of the city of Baghdad and bad in the south of Baghdad. The deterioration of water quality was due to many reasons such as the discharge of wastewater directly into the river without pretreatment, increase in (Eclectic conductivity, Turbidity, and total suspended solids, total hardness, Iron ion, the fecal coliform) concentrations, and Climate change, therefore, Tigris River needs intensive treatment before using by humans.