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Your search keyword '"Elliott, W.M."' showing total 18 results
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18 results on '"Elliott, W.M."'

1. Adenovirus E1A upregulates interleukin-8 expression induced by endotoxin in pulmonary epithelial cells

Author

Keicho, N., Elliott, W.M., Hogg, J.C., and Hayashi, S.

Subjects
Cytokines -- Physiological aspects, Adenoviruses -- Physiological aspects, Interleukins -- Physiological aspects, Biological sciences
Abstract

The effects of the adenoviral E1A DNA on the expression of a variety of candidate cytokine genes in the lung epithelial cells were analyzed in isolated human pulmonary epithelial cells. Administration of lipopolysaccharides in isolated E1A-producing human pulmonary epithelial cells induced the expression of inflammatory cytokines. On the other hand, human pulmonary epithelial cells without E1A did not induce the expression of interleukins.

Published
1997

2. Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease

Author

Hansel, N.N., Pare, P.D., Rafaels, N., Sin, D.D., Sandford, A., Daley, D., Vergara, C., Huang, L.L., Elliott, W.M., Pascoe, C.D., Arsenault, B.A., Postma, D.S., Boezen, H.M., Bosse, Y., Berge, M. van den, Hiemstra, P.S., Cho, M.H., Litonjua, A.A., Sparrow, D., Ober, C., Wise, R.A., Connett, J., Neptune, E.R., Beaty, T.H., Ruczinski, I., Mathias, R.A., Barnes, K.C., Lung Hlth Study, Groningen Research Institute for Asthma and COPD (GRIAC), and Life Course Epidemiology (LCE)

Subjects
Risk, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Quantitative Trait Loci, Clinical Biochemistry, Genome-wide association study, Quantitative trait locus, LUNG HEALTH, VARIANTS, delta-sarcoglycan, EARLY INTERVENTION, eQTL, Polymorphism, Single Nucleotide, bronchial responsiveness, Pulmonary Disease, Chronic Obstructive, Sarcoglycans, airway reactivity, Genotype, medicine, Humans, COPD, Genetic Predisposition to Disease, CORONARY-HEART-DISEASE, 1000 Genomes Project, Molecular Biology, Original Research, Lung, Myosin Heavy Chains, business.industry, SMOOTH-MUSCLE, Cell Biology, SMOKING-CESSATION, medicine.disease, respiratory tract diseases, medicine.anatomical_structure, Expression quantitative trait loci, Immunology, BRONCHIAL HYPERRESPONSIVENESS, RISK-FACTORS, METHACHOLINE, business, Imputation (genetics), Genome-Wide Association Study
Abstract

Increased airway responsiveness is linked to lung function decline and mortality in subjects with chronic obstructive pulmonary disease (COPD); however, the genetic contribution to airway responsiveness remains largely unknown. A genome-wide association study (GWAS) was performed using the Illumina (San Diego, CA) Human660W-Quad BeadChip on European Americans with COPD from the Lung Health Study. Linear regression models with correlated meta-analyses, including data from baseline (n = 2,814) and Year 5 (n = 2,657), were used to test for common genetic variants associated with airway responsiveness. Genotypic imputation was performed using reference 1000 Genomes Project data. Expression quantitative trait loci (eQTL) analyses in lung tissues were assessed for the top 10 markers identified, and immunohistochemistry assays assessed protein staining for SGCD and MYH15. Four genes were identified within the top 10 associations with airway responsiveness. Markers on chromosome 9p21.2 flanked by LINGO2 met a predetermined threshold of genome-wide significance (P 9.57 × 10(-8)). Markers on chromosomes 3q13.1 (flanked by MYH15), 5q33 (SGCD), and 6q21 (PDSS2) yielded suggestive evidence of association (9.57 × 10(-8) P ≤ 4.6 × 10(-6)). Gene expression studies in lung tissue showed single nucleotide polymorphisms on chromosomes 5 and 3 to act as eQTL for SGCD (P = 2.57 × 10(-9)) and MYH15 (P = 1.62 × 10(-6)), respectively. Immunohistochemistry confirmed localization of SGCD protein to airway smooth muscle and vessels and MYH15 to airway epithelium, vascular endothelium, and inflammatory cells. We identified novel loci associated with airway responsiveness in a GWAS among smokers with COPD. Risk alleles on chromosomes 5 and 3 acted as eQTLs for SGCD and MYH15 messenger RNA, and these proteins were expressed in lung cells relevant to the development of airway responsiveness.

Published
2015

3. Molecular mechanisms underlying variations in lung function: A systems genetics analysis

Author

Obeidat, M. (Ma'en), Hao, K. (Ke), Bossé, Y. (Yohan), Nickle, D.C. (David), Nie, Y. (Yunlong), Postma, D.S. (Dirkje), Laviolette, M. (Michel), Sandford, A. (Andrew), Daley, D. (Denise), Hogg, J.C. (James), Elliott, W.M., Fishbane, N. (Nick), Timens, W. (Wim), Hysi, P.G. (Pirro), Kaprio, J. (Jaakko), Wilson, J.F. (James F), Hui, J. (Jennie), Rawal, R. (Rajesh), Schulz, H. (Holger), Stubbe, B. (Beate), Hayward, C. (Caroline), Polasek, O. (Ozren), Jarvelin, M.-R. (Marjo-Riitta), Zhao, J.H. (Jing Hua), Jarvis, D.L. (Deborah L.), Kähönen, M. (Mika), Franceschini, N. (Nora), North, K.E. (Kari), Loth, D.W. (Daan), Brusselle, G.G. (Guy), Smith, A.V. (Davey), Gudnason, V. (Vilmundur), Bartz, T.M. (Traci M.), Wilk, J.B. (Jemma), O'Connor, G.T. (George), Cassano, P.A. (Patricia), Tang, W. (Wenbo), Wain, L.V. (Louise), Artigas, M.S., Gharib, S.A. (Sina), Strachan, D.P. (David P.), Sin, D.D., Tobin, M.D. (Martin), London, S.J. (Stephanie J.), Hall, I.P. (Ian), Paré, P.D. (Peter), Obeidat, M. (Ma'en), Hao, K. (Ke), Bossé, Y. (Yohan), Nickle, D.C. (David), Nie, Y. (Yunlong), Postma, D.S. (Dirkje), Laviolette, M. (Michel), Sandford, A. (Andrew), Daley, D. (Denise), Hogg, J.C. (James), Elliott, W.M., Fishbane, N. (Nick), Timens, W. (Wim), Hysi, P.G. (Pirro), Kaprio, J. (Jaakko), Wilson, J.F. (James F), Hui, J. (Jennie), Rawal, R. (Rajesh), Schulz, H. (Holger), Stubbe, B. (Beate), Hayward, C. (Caroline), Polasek, O. (Ozren), Jarvelin, M.-R. (Marjo-Riitta), Zhao, J.H. (Jing Hua), Jarvis, D.L. (Deborah L.), Kähönen, M. (Mika), Franceschini, N. (Nora), North, K.E. (Kari), Loth, D.W. (Daan), Brusselle, G.G. (Guy), Smith, A.V. (Davey), Gudnason, V. (Vilmundur), Bartz, T.M. (Traci M.), Wilk, J.B. (Jemma), O'Connor, G.T. (George), Cassano, P.A. (Patricia), Tang, W. (Wenbo), Wain, L.V. (Louise), Artigas, M.S., Gharib, S.A. (Sina), Strachan, D.P. (David P.), Sin, D.D., Tobin, M.D. (Martin), London, S.J. (Stephanie J.), Hall, I.P. (Ian), and Paré, P.D. (Peter)

Abstract

Background: Lung function measures reflect the physiological state of the lung, and are essential to the diagnosis of chronic obstructive pulmonary disease (COPD). The SpiroMeta-CHARGE consortium undertook the largest genome-wide association study (GWAS) so far (n=48 201) for forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) in

Published
2015
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5. Seeking the hole truth

Author

Shor, Peter, Elliott, W.M. Carter, and Crowe, Michael F.

Subjects
Science and technology
Abstract

Rather than concluding that the object that hit Canada 12,900 years ago was a comet, I wonder whether there might not be an alternate reason that geologists haven't discovered a [...]

Published
2007

8. A METHOD OF DETECTING OVIPOSITION IN EUROPEAN CORN BORER MOTHS, OSTRINIA NUBILALIS(LEPIDOPTERA: PYRALIDAE), AND ITS RELATION TO SUBSEQUENT LARVAL DAMAGE TO PEPPERS

Author

Elliott, W.M., McClanahan, R.J., and Founk, J.

Abstract

AbstractThe formation of a yellow band inside the stalk of each ovariole was a good indicator that a female European corn borer had laid eggs. The absence of these bands was less reliable as an indicator that no eggs had been laid, probably due to the time taken for the bands to form. The numbers of moths accumulating in a light trap over a week at Harrow, Ontario, and the numbers of females estimated to have laid eggs correlated significantly with the numbers of larvae developing in nearby green pepper plots 3, 4, and 5 weeks later during second generation flights. This enabled linear equations for forecasting pepper damage to be developed, in which the dissection data was more useful than the total moth catch alone.

Published
1978
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