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Molecular mechanisms underlying variations in lung function: A systems genetics analysis

Authors :
Obeidat, M. (Ma'en)
Hao, K. (Ke)
Bossé, Y. (Yohan)
Nickle, D.C. (David)
Nie, Y. (Yunlong)
Postma, D.S. (Dirkje)
Laviolette, M. (Michel)
Sandford, A. (Andrew)
Daley, D. (Denise)
Hogg, J.C. (James)
Elliott, W.M.
Fishbane, N. (Nick)
Timens, W. (Wim)
Hysi, P.G. (Pirro)
Kaprio, J. (Jaakko)
Wilson, J.F. (James F)
Hui, J. (Jennie)
Rawal, R. (Rajesh)
Schulz, H. (Holger)
Stubbe, B. (Beate)
Hayward, C. (Caroline)
Polasek, O. (Ozren)
Jarvelin, M.-R. (Marjo-Riitta)
Zhao, J.H. (Jing Hua)
Jarvis, D.L. (Deborah L.)
Kähönen, M. (Mika)
Franceschini, N. (Nora)
North, K.E. (Kari)
Loth, D.W. (Daan)
Brusselle, G.G. (Guy)
Smith, A.V. (Davey)
Gudnason, V. (Vilmundur)
Bartz, T.M. (Traci M.)
Wilk, J.B. (Jemma)
O'Connor, G.T. (George)
Cassano, P.A. (Patricia)
Tang, W. (Wenbo)
Wain, L.V. (Louise)
Artigas, M.S.
Gharib, S.A. (Sina)
Strachan, D.P. (David P.)
Sin, D.D.
Tobin, M.D. (Martin)
London, S.J. (Stephanie J.)
Hall, I.P. (Ian)
Paré, P.D. (Peter)
Obeidat, M. (Ma'en)
Hao, K. (Ke)
Bossé, Y. (Yohan)
Nickle, D.C. (David)
Nie, Y. (Yunlong)
Postma, D.S. (Dirkje)
Laviolette, M. (Michel)
Sandford, A. (Andrew)
Daley, D. (Denise)
Hogg, J.C. (James)
Elliott, W.M.
Fishbane, N. (Nick)
Timens, W. (Wim)
Hysi, P.G. (Pirro)
Kaprio, J. (Jaakko)
Wilson, J.F. (James F)
Hui, J. (Jennie)
Rawal, R. (Rajesh)
Schulz, H. (Holger)
Stubbe, B. (Beate)
Hayward, C. (Caroline)
Polasek, O. (Ozren)
Jarvelin, M.-R. (Marjo-Riitta)
Zhao, J.H. (Jing Hua)
Jarvis, D.L. (Deborah L.)
Kähönen, M. (Mika)
Franceschini, N. (Nora)
North, K.E. (Kari)
Loth, D.W. (Daan)
Brusselle, G.G. (Guy)
Smith, A.V. (Davey)
Gudnason, V. (Vilmundur)
Bartz, T.M. (Traci M.)
Wilk, J.B. (Jemma)
O'Connor, G.T. (George)
Cassano, P.A. (Patricia)
Tang, W. (Wenbo)
Wain, L.V. (Louise)
Artigas, M.S.
Gharib, S.A. (Sina)
Strachan, D.P. (David P.)
Sin, D.D.
Tobin, M.D. (Martin)
London, S.J. (Stephanie J.)
Hall, I.P. (Ian)
Paré, P.D. (Peter)
Publication Year :
2015

Abstract

Background: Lung function measures reflect the physiological state of the lung, and are essential to the diagnosis of chronic obstructive pulmonary disease (COPD). The SpiroMeta-CHARGE consortium undertook the largest genome-wide association study (GWAS) so far (n=48 201) for forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) in

Details

Database :
OAIster
Notes :
application/pdf, The Lancet Respiratory Medicine vol. 3 no. 10, pp. 782-795, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1022217693
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1016.S2213-2600(15)00380-X