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Designing scaffolds to fit with essential requirements for wound dressings is still a challenge. A material with high antibacterial activity and biocompatibility is targeted. In this case, the electrospinning technique is used to fabricate a nanofiber scaffold of polylactic acid (PLA) embedded with ginger and/or molybdenum trioxide (MoO3) and cupric oxide (CuO). The nanofiber scaffolds were examined using SEM, TEM, Raman, XRD, FTIR, and EDX. In addition, the surface topography of the nanofiber scaffold of MoO3/ginger@PLA showed that the nanofiber diameters differ from 0.085 to 0.34 µm. Furthermore, the contact angle of the water drop on the surface of the pure PLA and MoO3/CuO/GO/ginger@PLA is remarkably changed from 32.3° to 18.9°. Moreover, the cell viability test of the composition MoO3/CuO/GO/ginger@PLA is above the IC50 at all concentrations. Meanwhile, the antibacterial test exhibited antibacterial activity against E. coli and S. aureus for the scaffolds, with an inhibition zone of 23 ± 0.816 mm and 16.33 ± 0.942 mm for MoO3/CuO/ginger@PLA and 20.3 ± 0.471 mm and 15.33 ± 0.943 mm for MoO3/CuO/GO/ginger@PLA. The obtained results are appropriate to aid the cells to grow and proliferate. As a result of that, the fabricated scaffolds could be utilized in biomedical applications. [ABSTRACT FROM AUTHOR]