Electrospun nanofibrous scaffolds of polylactic acid loaded with ginger/MoO3/CuO/graphene oxide: biocompatibility and antibacterial activity.

Designing scaffolds to fit with essential requirements for wound dressings is still a challenge. A material with high antibacterial activity and biocompatibility is targeted. In this case, the electrospinning technique is used to fabricate a nanofiber scaffold of polylactic acid (PLA) embedded with ginger and/or molybdenum trioxide (MoO₃) and cupric oxide (CuO). The nanofiber scaffolds were examined using SEM, TEM, Raman, XRD, FTIR, and EDX. In addition, the surface topography of the nanofiber scaffold of MoO₃/ginger@PLA showed that the nanofiber diameters differ from 0.085 to 0.34 µm. Furthermore, the contact angle of the water drop on the surface of the pure PLA and MoO₃/CuO/GO/ginger@PLA is remarkably changed from 32.3° to 18.9°. Moreover, the cell viability test of the composition MoO₃/CuO/GO/ginger@PLA is above the IC₅₀ at all concentrations. Meanwhile, the antibacterial test exhibited antibacterial activity against E. coli and S. aureus for the scaffolds, with an inhibition zone of 23 ± 0.816 mm and 16.33 ± 0.942 mm for MoO₃/CuO/ginger@PLA and 20.3 ± 0.471 mm and 15.33 ± 0.943 mm for MoO₃/CuO/GO/ginger@PLA. The obtained results are appropriate to aid the cells to grow and proliferate. As a result of that, the fabricated scaffolds could be utilized in biomedical applications. [ABSTRACT FROM AUTHOR]