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3. Psoriatic Arthropathy

Author

Bishara Garzuzi, Rema, Gazitt, Tal, Elias, Muna, Zisman, Devy, Slobodin, Gleb, editor, and Shoenfeld, Yehuda, editor

Published
2020
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6. Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S.

Author

Zisman, Devy, Sabtan, Hala, Rahat, Maya M., Simanovich, Elina, Haddad, Amir, Gazitt, Tal, Feld, Joy, Slobodin, Gleb, Kibari, Adi, Elias, Muna, and Rahat, Michal A.

Subjects
ENDOSTATIN, VASCULAR endothelial growth factors, RHEUMATOID arthritis, GENE expression, MATRIX metalloproteinases, CELL lines
Abstract

Angiogenesis is critical for rheumatoid arthritis (RA) progression. The effects of tofacitinib, a JAK-STAT inhibitor used for RA treatment, on angiogenesis in RA are unclear. We, therefore, evaluated the levels of angiogenic factors in two systems of a human co-culture of fibroblast (HT1080) and monocytic (U937) cell lines treated with tofacitinib and in serum samples from RA patients before and after six months of tofacitinib treatment. Tofacitinib reduced CD147 levels, matrix metalloproteinase-9 (MMP-9) activity, and angiogenic potential but increased endostatin levels and secreted proteasome 20S activity. In vitro, tofacitinib did not change CD147 mRNA but increased miR-146a-5p expression and reduced STAT3 phosphorylation. We recently showed that CD147 regulates the ability of MMP-9 and secreted proteasome 20S to cleave collagen XVIIIA into endostatin. We show here that tofacitinib-enhanced endostatin levels are mediated by CD147, as CD147-siRNA or an anti-CD147 antibody blocked proteasome 20S activity. The correlation between CD147 and different disease severity scores supported this role. Lastly, tofacitinib reduced endostatin' s degradation by inhibiting cathepsin S activity and recombinant cathepsin S reversed this in both systems. Thus, tofacitinib inhibits angiogenesis by reducing pro-angiogenic factors and enhancing the anti-angiogenic factor endostatin in a dual effect mediated partly through CD147 and partly through cathepsin S. [ABSTRACT FROM AUTHOR]

Published
2024
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9. A deep look into the storm: Israeli multi-center experience of coronavirus disease 2019 (COVID-19) in patients with autoimmune inflammatory rheumatic diseases before and after vaccinations

Author

Kharouf, Fadi, primary, Eviatar, Tali, additional, Braun, Maya, additional, Pokroy-Shapira, Elisheva, additional, Brodavka, Michal, additional, Zloof, Yair, additional, Agmon-Levin, Nancy, additional, Toledano, Kochava, additional, Oren, Shirly, additional, Lidar, Merav, additional, Zisman, Devy, additional, Tavor, Yonit, additional, Amit-Vazina, Mirit, additional, Sabbah, Firas, additional, Breuer, Gabriel S., additional, Dagan, Amir, additional, Beshara-Garzuzi, Rima, additional, Markovits, Doron, additional, Elias, Muna, additional, Feld, Joy, additional, Tayer-Shifman, Oshrat, additional, Gazitt, Tal, additional, Reitblatt, Tatiana, additional, Rubin, Limor, additional, Haddad, Amir, additional, Giryes, Sami, additional, Paran, Daphna, additional, Peleg, Hagit, additional, Molad, Yair, additional, Elkayam, Ori, additional, Mevorach, Dror, additional, Balbir-Gurman, Alexandra, additional, and Braun-Moscovici, Yolanda, additional

Published
2023
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10. Development of Autoantibodies Following BNT162b2 mRNA COVID-19 Vaccination and Their Association with Disease Flares in Adult Patients with Autoimmune Inflammatory Rheumatic Diseases (AIIRD) and the General Population: Results of 1-Year Prospective Follow-Up Study

Author

Gazitt, Tal, primary, Eviatar, Tali, additional, Shear, Jacqueline, additional, Meidan, Roni, additional, Furer, Victoria, additional, Feld, Joy, additional, Haddad, Amir, additional, Elias, Muna, additional, Hijazi, Nizar, additional, Stein, Nili, additional, Shaked Mishan, Pninit, additional, Zetser, Anna, additional, Peleg, Hagit, additional, Elkayam, Ori, additional, and Zisman, Devy, additional

Published
2023
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12. Immunogenicity induced by two and three doses of the BNT162b2 mRNA vaccine in patients with autoimmune inflammatory rheumatic diseases and immunocompetent controls: a longitudinal multicentre study

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Freund, Tal, additional, Peleg, Hagit, additional, Paran, Daphna, additional, Levartovsky, David, additional, Kaufman, Ilana, additional, Broyde, Adi, additional, Elalouf, Ofir, additional, Polachek, Ari, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazitt, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Gertel, Smadar, additional, Pel, Sara, additional, Nevo, Sharon, additional, Hagin, David, additional, Zisman, Devy, additional, and Elkayam, Ori, additional

Published
2022
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13. Predictors of Immunogenic Response to the BNT162b2 mRNA COVID-19 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases Treated with Rituximab

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Zisman, Devy, additional, Peleg, Hagit, additional, Braun-Moscovici, Yolanda, additional, Balbir-Gurman, Alexandra, additional, Paran, Daphna, additional, Levartovsky, David, additional, Zisapel, Michael, additional, Elalouf, Ofir, additional, Kaufman, Ilana, additional, Broyde, Adi, additional, Polachek, Ari, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazitt, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Pel, Sara, additional, Nevo, Sharon, additional, and Elkayam, Ori, additional

Published
2022
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15. Predictors of an Immunogenic Response to the BNT162b2 mRNA COVID-19 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases Treated with Rituximab: A Multicenter Study

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Zisman, Devy, additional, Peleg, Hagit, additional, Braun-Moscovici, Yolanda, additional, Balbir-Gurman, Alexandra, additional, Paran, Daphna, additional, Levartovsky, David, additional, Zisapel, Michael, additional, Elalouf, Ofir, additional, Kaufman, Ilana, additional, Broyde, Adi, additional, Polachek, Ari, additional, Meridor, Katya, additional, Nochomovitz, Hila, additional, Silberman, Adi, additional, Rosenberg, Dana, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazzit, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Pel, Sara, additional, Nevo, Sharon, additional, and Elkayam, Ori, additional

Published
2021
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16. Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147

Author

Zisman, Devy, primary, Safieh, Mirna, additional, Simanovich, Elina, additional, Feld, Joy, additional, Kinarty, Amalia, additional, Zisman, Liron, additional, Gazitt, Tal, additional, Haddad, Amir, additional, Elias, Muna, additional, Rosner, Itzhak, additional, Kaly, Lisa, additional, and Rahat, Michal A., additional

Published
2021
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19. Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Zisman, Devy, additional, Peleg, Hagit, additional, Paran, Daphna, additional, Levartovsky, David, additional, Zisapel, Michael, additional, Elalouf, Ofir, additional, Kaufman, Ilana, additional, Meidan, Roni, additional, Broyde, Adi, additional, Polachek, Ari, additional, Wollman, Jonathan, additional, Litinsky, Ira, additional, Meridor, Katya, additional, Nochomovitz, Hila, additional, Silberman, Adi, additional, Rosenberg, Dana, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazzit, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Shefer, Gabi, additional, Sharon, Orly, additional, Pel, Sara, additional, Nevo, Sharon, additional, and Elkayam, Ori, additional

Published
2021
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20. Immune-Mediated Disease Flares or New-Onset Disease in 27 Subjects Following mRNA/DNA SARS-CoV-2 Vaccination

Author

Watad, Abdulla, primary, De Marco, Gabriele, additional, Mahajna, Hussein, additional, Druyan, Amit, additional, Eltity, Mailam, additional, Hijazi, Nizar, additional, Haddad, Amir, additional, Elias, Muna, additional, Zisman, Devy, additional, Naffaa, Mohammad E., additional, Brodavka, Michal, additional, Cohen, Yael, additional, Abu-Much, Arsalan, additional, Abu Elhija, Muhanad, additional, Bridgewood, Charlie, additional, Langevitz, Pnina, additional, McLorinan, Joanna, additional, Bragazzi, Nicola Luigi, additional, Marzo-Ortega, Helena, additional, Lidar, Merav, additional, Calabrese, Cassandra, additional, Calabrese, Leonard, additional, Vital, Edward, additional, Shoenfeld, Yehuda, additional, Amital, Howard, additional, and McGonagle, Dennis, additional

Published
2021
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21. Immunogenicity and safety of vaccination against seasonal influenza vaccine in patients with psoriatic arthritis treated with secukinumab

Author

Furer, Victoria, primary, Zisman, Devy, additional, Kaufman, Ilana, additional, Arad, Uri, additional, Berman, Mark, additional, Sarbagil-Maman, Hagit, additional, Elias, Muna, additional, Hadad, Amir, additional, Paran, Daphna, additional, Drori, Yaron, additional, Friedman, Nehemya, additional, Mandelboim, Michal, additional, and Elkayam, Ori, additional

Published
2020
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24. Increased Prevalence of Metabolic Syndrome and Adipocytokine Levels in a Psoriatic Arthritis Cohort.

Author

Feld J, Nissan S, Eder L, Rahat MA, Elias M, Rimar D, Laor A, Bitterman H, and Zisman D

Subjects
Ambulatory Care Facilities statistics & numerical data, Antirheumatic Agents classification, Antirheumatic Agents therapeutic use, Biomarkers blood, Blood Glucose analysis, Cholesterol, HDL blood, Correlation of Data, Female, Humans, Israel epidemiology, Male, Middle Aged, Risk Factors, Triglycerides blood, Tumor Necrosis Factor-alpha antagonists & inhibitors, Waist Circumference, Adipokines blood, Arthritis, Psoriatic diagnosis, Arthritis, Psoriatic drug therapy, Arthritis, Psoriatic epidemiology, Arthritis, Psoriatic metabolism, Metabolic Syndrome blood, Metabolic Syndrome diagnosis, Metabolic Syndrome epidemiology
Abstract

Objective: The aims of this study were to evaluate the prevalence of metabolic syndrome (MetS) in psoriatic arthritis (PsA) patients according to the most recent definition in a Mediterranean population and to determine its association with biomarkers of inflammation and serum adipocytokine levels., Methods: Demographic, clinical, and laboratory data were collected on 74 patients with PsA and 82 control subjects. The presence of MetS was determined according to the current "harmonization" definition. Serum adipocytokines were analyzed. Continuous variables were compared by t test and discrete variables by χ test. Multivariate regression models compared the association between the presence of MetS and the blood levels of adipocytokines., Results: The prevalence of MetS was higher in PsA patients compared with the control group: 54.8% versus 36.6%, respectively (P = 0.02; odds ratio, 2.33; 95% confidence interval, 1.16-4.69). The main difference between the 2 groups was waist circumference. No association was found between MetS and parameters of articular and skin disease activity or treatment. Leptin levels and leptin/adiponectin ratio were higher in PsA patients compared with control subjects: 83.4 versus 51.7 ng/mL (P = 0.001) and 6.3 × 10 versus 4.1 × 10 (P = 0.015), respectively. There was no significant difference in the adiponectin levels between the groups., Conclusions: The prevalence of MetS was higher in PsA patients compared with non-PsA control subjects in this Mediterranean population. Clinicians caring for PsA patients ought to be aware of the increased risk of MetS in PsA patients, confirmed in different regions worldwide. The increased MetS seems to be linked to central obesity in these patients, and appropriate treatment recommendations are advised.

Published
2018
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