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Increased Prevalence of Metabolic Syndrome and Adipocytokine Levels in a Psoriatic Arthritis Cohort.
- Source :
-
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases [J Clin Rheumatol] 2018 Sep; Vol. 24 (6), pp. 302-307. - Publication Year :
- 2018
-
Abstract
- Objective: The aims of this study were to evaluate the prevalence of metabolic syndrome (MetS) in psoriatic arthritis (PsA) patients according to the most recent definition in a Mediterranean population and to determine its association with biomarkers of inflammation and serum adipocytokine levels.<br />Methods: Demographic, clinical, and laboratory data were collected on 74 patients with PsA and 82 control subjects. The presence of MetS was determined according to the current "harmonization" definition. Serum adipocytokines were analyzed. Continuous variables were compared by t test and discrete variables by χ test. Multivariate regression models compared the association between the presence of MetS and the blood levels of adipocytokines.<br />Results: The prevalence of MetS was higher in PsA patients compared with the control group: 54.8% versus 36.6%, respectively (P = 0.02; odds ratio, 2.33; 95% confidence interval, 1.16-4.69). The main difference between the 2 groups was waist circumference. No association was found between MetS and parameters of articular and skin disease activity or treatment. Leptin levels and leptin/adiponectin ratio were higher in PsA patients compared with control subjects: 83.4 versus 51.7 ng/mL (P = 0.001) and 6.3 × 10 versus 4.1 × 10 (P = 0.015), respectively. There was no significant difference in the adiponectin levels between the groups.<br />Conclusions: The prevalence of MetS was higher in PsA patients compared with non-PsA control subjects in this Mediterranean population. Clinicians caring for PsA patients ought to be aware of the increased risk of MetS in PsA patients, confirmed in different regions worldwide. The increased MetS seems to be linked to central obesity in these patients, and appropriate treatment recommendations are advised.
- Subjects :
- Ambulatory Care Facilities statistics & numerical data
Antirheumatic Agents classification
Antirheumatic Agents therapeutic use
Biomarkers blood
Blood Glucose analysis
Cholesterol, HDL blood
Correlation of Data
Female
Humans
Israel epidemiology
Male
Middle Aged
Risk Factors
Triglycerides blood
Tumor Necrosis Factor-alpha antagonists & inhibitors
Waist Circumference
Adipokines blood
Arthritis, Psoriatic diagnosis
Arthritis, Psoriatic drug therapy
Arthritis, Psoriatic epidemiology
Arthritis, Psoriatic metabolism
Metabolic Syndrome blood
Metabolic Syndrome diagnosis
Metabolic Syndrome epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-7355
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
- Publication Type :
- Academic Journal
- Accession number :
- 29708516
- Full Text :
- https://doi.org/10.1097/RHU.0000000000000721