36 results on '"Elavarasi, E."'
Search Results
2. Tamil Nadu Pregnancy and Heart Disease Registry (TNPHDR): design and methodology
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Gnanaraj, Justin Paul, Princy, S Anne, Sliwa-Hahnle, Karen, Sathyendra, Sowmya, Jeyabalan, Nambirajan, Sethumadhavan, Ragothaman, G, Selvarani, Sumathi, N., S, Vinotha, P, Pachaiappan, Murali, Vimali, B, Shanthirani, T, Gomathi, P, Muthuprabha, Jeemon, Panniyammakal, Elavarasi, E., R, Rajarajeshwari, S, Vijaya, and K, Kanmani
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- 2022
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3. Acute pulmonary embolism: in hospital outcome from a prospective observational registry (M-PER) from a low-and middle-income country
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Gnanaraj, J P, primary, Vivek, J, additional, Rajesh, S, additional, Nilavan, A, additional, Rajasekar Ramesh, D, additional, Elangovan, C, additional, Elavarasi, E, additional, Ravindran, R, additional, Nageswaran, P M, additional, Tamilselvan, S, additional, Pratap Kumar, G, additional, Venkatesan, S, additional, Manohar, G, additional, Swaminathan, N, additional, and Ravishankar, G, additional
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- 2022
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4. Estimation and Evaluation of Mexiletine for Bio-availability and Bio-equivalence studies by Liquid phase extraction using LC-MS/MS
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Binoy Varghese Cherian, Elavarasi E, Palani Shanmugasundaram, and Vijey Aanandhi M
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Chromatography ,Chemistry ,BIO-EQUIVALENCE ,Mexiletine ,Extraction (chemistry) ,Lc ms ms ,medicine ,BIO-AVAILABILITY ,Liquid phase ,General Pharmacology, Toxicology and Pharmaceutics ,medicine.drug - Abstract
The work aims to develop an appropriate method for mexiletine with 35-65% recovery by the LPE method with efficient and selective efficacy of the IS and analyte for the analysis under Liquid Chromatography-Mass Spectrometry/ Mass Spectrometry. This method also reveals the bio-availability and bio-equivalence report for Internal Standard & working standard. At first, the selection of proper IS. The Internal standard should be structurally more similar to mexiletine. The selection of method plays a major role in which extraction procedure is done either by LPE or SPE. The selection of separation procedure should be either isocratic or gradient. Selection of column on bases separation principle of the compound. Since separation is the major principle for chromatography. Argon and Nitrogen Gas is used as carries with a flow-rate of 2L min. Temperature at 20°C, the pressure at 20psi. If the instrument doesn't show any peak or response in after loading sample, check the columns is an aqueous or reverse-phase and then submit the sample. Check all the solution and column and temperature and system stability before loading the sample. After loading the sample, must form calibration curve it must form linearity. The method found should possess the following parameters Specific & Selectivity, Precision & Accuracy. The work aims to develop a simple, elegant way for quantification of a molecule and the method determined will have recovery of 35-65% worldwide. This quantification will be further utilized in Full-Method Validation.
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- 2021
5. Additional file 2 of Tamil Nadu Pregnancy and Heart Disease Registry (TNPHDR): design and methodology
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Gnanaraj, Justin Paul, Princy, S Anne, Sliwa-Hahnle, Karen, Sathyendra, Sowmya, Jeyabalan, Nambirajan, Sethumadhavan, Ragothaman, G, Selvarani, Sumathi, N., S, Vinotha, P, Pachaiappan, Murali, Vimali, B, Shanthirani, T, Gomathi, P, Muthuprabha, Jeemon, Panniyammakal, Elavarasi, E., R, Rajarajeshwari, S, Vijaya, and K, Kanmani
- Abstract
Additional file 2: Case report form booklet
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- 2022
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6. Additional file 1 of Tamil Nadu Pregnancy and Heart Disease Registry (TNPHDR): design and methodology
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Gnanaraj, Justin Paul, Princy, S Anne, Sliwa-Hahnle, Karen, Sathyendra, Sowmya, Jeyabalan, Nambirajan, Sethumadhavan, Ragothaman, G, Selvarani, Sumathi, N., S, Vinotha, P, Pachaiappan, Murali, Vimali, B, Shanthirani, T, Gomathi, P, Muthuprabha, Jeemon, Panniyammakal, Elavarasi, E., R, Rajarajeshwari, S, Vijaya, and K, Kanmani
- Abstract
Additional file 1: List of participating sites with investigators
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- 2022
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7. Additional file 3 of Tamil Nadu Pregnancy and Heart Disease Registry (TNPHDR): design and methodology
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Gnanaraj, Justin Paul, Princy, S Anne, Sliwa-Hahnle, Karen, Sathyendra, Sowmya, Jeyabalan, Nambirajan, Sethumadhavan, Ragothaman, G, Selvarani, Sumathi, N., S, Vinotha, P, Pachaiappan, Murali, Vimali, B, Shanthirani, T, Gomathi, P, Muthuprabha, Jeemon, Panniyammakal, Elavarasi, E., R, Rajarajeshwari, S, Vijaya, and K, Kanmani
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Data_FILES - Abstract
Additional file 3: Standard operating procedure
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- 2022
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8. ST segment elevation myocardial infarction in inherited thrombophilia (Factor V Leiden mutation) - Does fibrinolysis with triple therapy score over primary percutaneous coronary intervention?
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Vinila, N., primary, Elavarasi, E., additional, Sharmila, B., additional, and Justin, Paul G., additional
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- 2021
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9. PERCUTANEOUS TRANSVENOUS MITRAL COMMISSUROTOMY IN PREGNANT WOMEN WITH SEVERE RHEUMATIC MITRAL STENOSIS: MATERNAL AND FOETAL OUTCOME
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Justin Paul Gnanaraj, Gnanavelu Ganesan, N. Swaminathan, Ravishankar G, Manohar G, Nageswaran M, Rajasekar Ramesh, Elangovan C, Pratap Kumar G, Tamilselvan K, Elavarasi E, Ravindran R, Dharmarajan G, Thiagarajan K, Venkatesan S, Vinila N, and Anju S
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Cardiology and Cardiovascular Medicine - Published
- 2022
10. Parametric Continuously Programmable Infinite Impulse Response Filter for Non-Linear Real-Time DSP Applications
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Elavarasi, E., primary and Manjunath., R., additional
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- 2020
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11. A Conservative Management of Keratocyst Odentogenic Tumor Using Cornoy’s Solution And Osteoinduction using Concentrated Growth Factor Mixed with Aotogenous Bone Graft – Randomized Clinical Research
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R. Muralidaran, Elavarasi E, K.Vinod Krishna, V.Sadesh Kannan, Prithivi Sankar Nanthakumar, and M. Mahalakshmi
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medicine.medical_specialty ,Ossification ,business.industry ,Growth factor ,medicine.medical_treatment ,Enucleation ,Mandible ,Dentistry ,030206 dentistry ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Maxilla ,medicine ,Cauterization ,medicine.symptom ,Keratocyst ,Complication ,business - Abstract
Aim: The objective of this study is the complete elimination of the Keratocystic Odentogenic Tumor (KCOT) along with lining epithelium at the initial operation and induces osteoblastic activity using Concentrated Growth Factor (CGF) derived from autologus blood. Materials: 10 cases were involved in the study; Male: Female ratio 6:4; Maxilla: Mandible ratio 5:5, with a mean age of 36 years. Method: All cases of KCOT were treated by enucleation and chemical cauterization using cornoy’s solution followed by placement of CGF in the dead space along with aotogenous bone graft mixed with red blood corpuscular layer. Results: Results were excellent in all the patients with very good ossification at the operated site and none of our patient had recurrence or post-operative complication.. Conclusion: This conservative management of KCOT using cornoy’s solution and placement of CGF allows
- Published
- 2016
12. A new atraumatic method of removing fractured palatal root using endodontic H-files luted with resin modified glass ionomercement: A pilot study
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Narayanan Gr, K Velavan, Kannan Vs, Danavel C, Ahamed As, and Elavarasi E
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lcsh:QD71-142 ,Fractured palatal root ,H- files ,business.industry ,Maxillary second molar ,Glass ionomer cement ,lcsh:Analytical chemistry ,Dentistry ,lcsh:RS1-441 ,Bioengineering ,Resin modified ,Mean age ,General Biochemistry, Genetics and Molecular Biology ,resin modified glass ionomer cement ,lcsh:Pharmacy and materia medica ,exodontia ,Dental Science - Original Article ,Setting time ,Maxillary first molar ,Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,business ,Palatal root - Abstract
Purpose: The purpose of this study is to evaluate the efficacy of using endodontic H-files luted with Resin modified glass ionomer cement (RMGIC) in removing fractured palatal root. Materials and Methods: This study consists of 30 patients, of which 16 were males and 14 were females with a mean age of 36 years. In which, 19 were maxillary first molar and 11 were maxillary second molar. In that, 18 were fractured at the level of apical 1/3 rd and 12 were at the level of apical 2/3 rd . All cases were first tried with endodontic H-files, within few attempts, it was wedged tightly in the remaining pulp chamber with one or two clockwise direction and using sudden jerk with a downward pull the remnant part was removed. The cases, which fail to deliver after several attempts were taken up for study. After sufficient isolation with a rubber dam and the socket was dried using sterile gauze, under good lighting and vision again the same file was introduced, which was now luted with RMGIC, after 5 min of setting time, the same attempt using sudden jerk with a downward pull was given. Results: In those 30 cases, 20 cases were removed in the first few attempts using endodontic H-files. The 10 cases (7 cases were apical 2/3 rd and 3 cases were of apical 1/3 rd ), which fails to come out were tried using endodontic H-files luted with RMGIC, in which 9 cases were successfully removed (90%) and 1 case of apical 1/3 rd was again failed to come out. Conclusion: Even though, the number of cases were too small to come to a definitive conclusion, the encouraging result (90%) and technically easy, this is a novel method of removing fractured palatal root atraumatically and devoid of any complication.
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- 2014
13. Lymphoepithelial cyst of the submandibular gland
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V Sadesh Kannan, K Velaven, Elavarasi E, A Saneem Ahamed, G R Sathyanarayanan, and J Roshni
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Pathology ,medicine.medical_specialty ,Enucleation ,lcsh:Analytical chemistry ,lcsh:RS1-441 ,Bioengineering ,Lymphoepithelial cyst ,Lyphoepithelial cyst ,General Biochemistry, Genetics and Molecular Biology ,lcsh:Pharmacy and materia medica ,stomatognathic system ,sub-mandibular gland ,Medicine ,Cyst ,General Pharmacology, Toxicology and Pharmaceutics ,benign neck lesion malignant transformation ,Floor of mouth ,lcsh:QD71-142 ,Salivary gland ,business.industry ,Ultrasonogram ,Dental Science - Case Report ,Branchial Cyst ,medicine.disease ,Submandibular gland ,medicine.anatomical_structure ,business - Abstract
Lymphoepithelial cysts are benign, slowly growing unilocular or multilocular lesions that appear in the head and neck. They are also called Branchial cyst. The head and neck sites are the salivary glands(more commonly parotid and rarely submandibular gland) and the oral cavity (usually the floor of the mouth). there are various methods of investigation available today, of which Fine needle aspiration cytology (FNAC) can be used to provide an immediate diagnosis of a lymphoepithelial cyst. The other investigations include, Ultrasonogram,and Computed tomography. It usually occurs due to the process of lymphocyte-induced cystic ductular dilatation and the confirmatory diagnosis is always made postoperatively by histopathological examination. The mainstay in the treatment of a lymphoepithelial cyst remains the surgical approach, which includes complete enucleation of the cyst along with total excision of the involved salivary gland. This is a report of a lymphoepithelial cyst involving the submandibular salivary gland and its management.
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- 2014
14. A Conservative Management of Keratocyst Odentogenic Tumor Using Cornoy’s Solution And Osteoinduction using Concentrated Growth Factor Mixed with Aotogenous Bone Graft – Randomized Clinical Research.
- Author
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Kannan, V.Sadesh, primary, Elavarasi, E., additional, Mahalakshmi, M., additional, Krishna, K.Vinod, additional, Muralidaran, R., additional, and Nanthakumar, Prithivi Sankar, additional
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- 2016
- Full Text
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15. A noble method of using intravenous infusion set as a stent in localized lower posterior vestibuloplasty: A technical note
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Velavan, K, primary, Kannan, VSadesh, additional, Ahamed, ASaneem, additional, Abia, VRoshmi, additional, and Elavarasi, E, additional
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- 2015
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16. A noble method of using intravenous infusion set as a stent in localized lower posterior vestibuloplasty: A technical note
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Elavarasi E, V Roshmi Abia, A Saneem Ahamed, V Sadesh Kannan, and K Velavan
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Orthodontics ,medicine.medical_specialty ,shallow vestibular sulcus ,Missing tooth ,Infusion set ,business.industry ,medicine.medical_treatment ,Vestibuloplasty ,Dental Science - Case Report ,vestibuloplasty ,Stent ,Bioengineering ,Technical note ,Prosthesis ,Customized stent ,General Biochemistry, Genetics and Molecular Biology ,Surgery ,posterior sulcus ,Vestibule ,medicine ,In patient ,General Pharmacology, Toxicology and Pharmaceutics ,business - Abstract
Vestibuloplasty is the procedure for shallow vestibule, prior to the prosthesis. Usually, vestibuloplasty is carried out in patients with completely edentulous arches. There are multiple techniques of vestibuloplasty described in the review of literature. However, it has not been emphasized on isolated shallow vestibule. This article describes our experience in the isolated or localized vestibuloplasty for a partially edentulous individual with a shallow vestibule pertaining to a single missing tooth.
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- 2015
17. Lymphoepithelial cyst of the submandibular gland
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Ahamed, ASaneem, primary, Kannan, VSadesh, additional, Velaven, K, additional, Sathyanarayanan, GR, additional, Roshni, J, additional, and Elavarasi, E, additional
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- 2014
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18. A new atraumatic method of removing fractured palatal root using endodontic H-files luted with resin modified glass ionomercement: A pilot study
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Kannan, VSadesh, primary, Ahamed, ASaneem, additional, Sathya Narayanan, GR, additional, Velavan, K, additional, Elavarasi, E, additional, and Danavel, C, additional
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- 2014
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19. Anterior maxillary osteotomy: A technical note for superior repositioning: A bird wing segment
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Kannan, VSadesh, primary, Ahamed, ASaneem, additional, Sathyanarayanan, GR, additional, Velaven, K, additional, Elavarasi, E, additional, and Danavel, C, additional
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- 2014
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20. Anterior maxillary osteotomy: A technical note for superior repositioning: A bird wing segment
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Elavarasi E, Ahamed As, Narayanan Gr, K Velaven, Danavel C, and Kannan Vs
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lcsh:QD71-142 ,Wing ,business.industry ,superior repositioning ,lcsh:Analytical chemistry ,Bone removal ,lcsh:RS1-441 ,Dentistry ,Bioengineering ,Technical note ,Mean age ,Maxillary Osteotomy ,General Biochemistry, Genetics and Molecular Biology ,lcsh:Pharmacy and materia medica ,medicine.anatomical_structure ,Incisor ,Tooth pulp stimulation ,Gummy smile ,Dental Science - Original Article ,medicine ,bird wing segment ,Anterior maxillary osteotomy ,General Pharmacology, Toxicology and Pharmaceutics ,business - Abstract
Aim: The aim of this study is to evaluate the efficacy of a single piece bird wing osteotectomy segment during anterior maxillary osteotomy (AMO) markedly reduces the duration of the surgery by nearly one-half of the time during bone removal with the conventional method thereby reducing the kinking effect to the palatal pedicle and gives good perfusion to the anterior segment. Materials and Methods: This study was conducted at Karpaga Vinayaga Institute of Dental Sciences composing of 20 patients in which male: female ratio was 8:12, with a mean age of 25-30 years. This bird wing segment technique is performed following presurgical orthodontics under the guidance of clinical assessment of the gummy smile with an incisal show when the lip is at repose (vertical maxillary excess), especially for the calculated amount of superior repositioning. It is calculated by subtracting 2 mm from the total amount of an incisor show when the lip is at repose. The normal incisal show when the lip is at repose is 2 mm. After conventional primary AMO cut was performed, the precise calculated. Results: All our cases were tested positive for pulp vitality, no relapse, and minimal edema and with no changes in the bite or dentoalveolar relation followed until 1 year postoperatively indicating a good perfusion to the anterior segment and all the patients were satisfied esthetically and free of complaints. Conclusion: This simple technique allows the precise amount of calculated bone removal in a single piece from the nasal floor markedly reduces the duration of the surgery by nearly one-half of the time during bone removal with the conventional method there by reducing the kinking effect to the palatal pedicle and maintains good perfusion.
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- 2014
21. Depression and stigma experience among patients with tuberculosis in urban and rural settings
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Anjuga Elavarasi, E., Smitha, M.C., Manasa, K., and Kruthika, B.N.
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Tuberculosis is one of the leading causes of morbidity and mortality in the globe. The most common infectious disease-related death in the world is tuberculosis. In 2020, an estimated 9.9 million people became ill with tuberculosis (TB), translating to 127 cases per 100,000 people. The stigma associated with tuberculosis (TB) causes people to put off seeking treatment and adhering to their treatment regimen. India has the highest prevalence of tuberculosis in the world. Depression and stigma oftem co-exist in people with tuberculosis.
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- 2023
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22. Reliability of smartphone images to assess plaque score among preschool children: a pilot study.
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Vijyakumar M, Ashari A, Yazid F, Rani H, and Kuppusamy E
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- Humans, Child, Preschool, Pilot Projects, Smartphone, Reproducibility of Results, Dental Plaque Index, Tooth, Dental Plaque diagnosis
- Abstract
This study assessed the reliability of smartphone images of plaque-disclosed anterior teeth for evaluating plaque scores among preschool children. Additionally, the reliability of plaque scores recorded from smartphone images of anterior teeth in representing the overall clinical plaque score was also assessed. Fifteen preschool children were recruited for this pilot study. The Simplified Debris Index (DI-S), the debris component of the Simplified Oral Hygiene Index, was used to record the plaque score. A plaque-disclosing tablet was used to disclose the plaque before the plaque score recording. Following that, the image of the anterior teeth (canine to canine) of both the upper and lower arch was captured using the smartphone. Each child had three different DI-S recorded. For the first recording of the overall clinical DI-S, the plaque score was recorded clinically from index teeth 55 (buccal), 51 (labial), 65 (buccal), 71 (labial), 75 (lingual) and 85 (lingual). For the second recording, anterior clinical DI-S, the plaque score was recorded clinically from the labial surfaces of six anterior teeth only (53, 51, 63, 73, 71 and 83). Two weeks later, anterior photographic DI-S (third recording) was done using the smartphone images of the same index teeth used for the second recording. The intra-class correlation coefficient (ICC) was calculated to evaluate the reliability of smartphone images in assessing plaque scores. The results showed high reliability (ICC = 0.987) between anterior clinical and anterior photographic examinations, indicating that smartphone images are highly reliable for evaluating plaque scores. Similarly, high reliability (ICC = 0.981) was also found for comparison between overall clinical DI-S and anterior photographic DI-S, indicating plaque scores recorded from smartphone images of anterior teeth alone can represent the overall clinical plaque score. This study suggests that smartphone images can be a valuable tool for remote screening and monitoring of oral hygiene in preschool children, contributing to better oral health outcomes., Competing Interests: The authors declare no conflict of interest., (©2024 The Author(s). Published by MRE Press.)
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- 2024
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23. User requirement gathering for online oral health education module development: Exploring parental perspective.
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Bala Sundram M, Kuppusamy E, Yazid F, and Rani H
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Objective: Dental caries is preventable, yet it remains a common childhood disease. As children are dependent on their parents for oral health care, oral health education for parents is essential to ensure they understand the risk factors and consequences of dental caries and their role in its prevention. This study aims to explore parents' oral health education needs to enable the development and provision of a tailored online oral health education module., Methods: Online focus group discussions were conducted among Malaysian parents to gather information about the content, layout and presentation of oral health information parents sought for the provision of oral health care for their children. Video recordings were transcribed verbatim and thematic analysis was performed using an inductive approach., Results: In total, 24 parents participated in the discussions and 4 main themes were uncovered. The first theme was perceived information needs related to dental caries, oral health care and the importance of deciduous teeth. The second theme was parents' preferred information resources which were social media, dentists, mobile phone applications and medical personnel. Thirdly, information delivery format and specific characteristics were recommended. The final theme was challenges and barriers faced in maintaining oral health due to parental constraints, child behaviour and external factors., Conclusion: Parents' profound feedback and experiential standpoint stipulate the need for the development and delivery of a comprehensible and visually engaging oral health education module by healthcare professionals via social media to enable access to evidence-based information consistently., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2023.)
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- 2023
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24. Association of early childhood caries and nutritional status: a scoping review.
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Lui DT, Wahab RMA, Kuppusamy E, Hamzaid NH, Hassan MR, and Yazid F
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- Child, Child, Preschool, Humans, Nutritional Status, Dental Caries Susceptibility, Dental Care, Dental Caries epidemiology, Pediatric Obesity
- Abstract
The most widespread non-communicable disease in the world is dental caries. Early childhood caries (ECC) is the presence of one or more decayed, missing or filled tooth surfaces in any primary tooth in children between birth and 71 months. The disease has been linked to failure to thrive, impaired speech and reduce food consumption due to pain and discomfort. Nutritional status of a child may also be affected by caries. Thus, we conducted a scoping review to review the association between ECC and nutritional status. A total of 492 articles published until December 2022 from three databases were obtained. 20 relevant articles meeting the inclusion criteria were included. From the included articles, dmft index was the most common dental assessment used, while all articles used anthropometric measurements for nutritional assessment except for two articles that used laboratory methods. Based on the results obtained, majority of the articles stated that there was an association between ECC in children with poor nutritional status, while only one study reported an association between ECC and overweight or obese children. Four papers showed no association. A more standardised and consistent study methodology, sample population and protocol in articles selected may help yield more reliable results., Competing Interests: The authors declare no conflict of interest., (©2023 The Author(s). Published by MRE Press.)
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- 2023
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25. Patterns of Parental Information Seeking Behavior on Early Childhood Caries: A Qualitative Exploration.
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Kuppusamy E, Ratnasingam MD, Yazid F, Rosli TI, Ali AM, Sockalingam SNMP, Ashari A, and S Bahiar AS
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Objectives: This study aims to explore the information-seeking behavior patterns of parents with children receiving treatment for early childhood caries (ECC)., Materials and Methods: Semistructured in-depth interviews were conducted with 20 parents of children with ECC. A topic guide was developed, focusing on questions relating to (i) the timing of their seeking information on ECC, (ii) the types of EEC information they seek, and (iii) the resources used to seek information. The interviews were audio-recorded and transcribed verbatim. Thematic analysis was performed, whereby the data were coded and categorized into themes and subthemes., Results: Four main themes were identified: the immediacy of seeking information, perceived information need, use of resources, and barriers to seeking information. Parents either sought information immediately after detecting changes to the appearance of their child's teeth, with some being aware of the changes after signs and symptoms developed. The types of information parents usually sought covered the disease, its prevention, and management. Common sources of information were friends, family, the internet, and healthcare professionals. Barriers to seeking information discussed by parents were lack of time as well as insufficiency and inaccuracy of the information they received., Conclusion: This study highlighted the need for comprehensive, tailored early education on ECC for parents using reliable information sources. There is also a need to empower other nondental healthcare professionals to provide oral healthcare education for parents., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Journal of International Society of Preventive and Community Dentistry.)
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- 2023
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26. Outcomes of ST Segment Elevation Myocardial Infarction without Standard Modifiable Cardiovascular Risk Factors - Newer Insights from a Prospective Registry in India.
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Justin Paul G, Sankaran S, Saminathan K, Iliyas M, Sethupathy S, Saravanan S, Prabhu SS, Kurian S, Srinivas S, Anurag P, Srinivasan K, Manimegalai E, Nagarajan S, Ramesh R, Nageswaran PM, Sangareddi V, and Govindarajulu R
- Subjects
- Male, Humans, Female, Risk Factors, India epidemiology, Heart Disease Risk Factors, Registries, Hospital Mortality, Treatment Outcome, ST Elevation Myocardial Infarction epidemiology, Cardiovascular Diseases etiology, Percutaneous Coronary Intervention adverse effects
- Abstract
Objectives: Patients with ST elevation myocardial infarction (STEMI) without standard modifiable cardiovascular risk factors (SMuRFs; dyslipidaemia, hypertension, diabetes mellitus and smoking) are reported to have a worse clinical outcome compared to those with SMuRFs. However, robust prospective data and low-and middle-income country perspective are lacking. We aimed to study the patients with first STEMI and assess the influence of SMuRFs on clinical outcomes by comparing the patients with and without SMuRFs., Methods: We included all consecutive STEMI patients without prior coronary artery disease enrolled in the Madras Medical College STEMI Registry from September 2018 to October 2019. We collected baseline clinical characteristics, revascularisation strategies and clinical outcome. We analysed suboptimal self-reported sleep duration as a 5
th extended SMuRF (eSMuRF). Primary outcome was in-hospital mortality. Secondary outcomes included in-hospital complications and one-year all-cause mortality., Results: Among 2,379 patients, 605 patients (25.4%) were SMuRF-less. More women were SMuRF-less than men (27.1% vs 22.1%; P = 0.012). SMuRF-less patients were older (57.44 ± 13.95 vs 55.68 ± 11.74; P < 0.001), more often former tobacco users (10.4% vs 5.0%; P < 0.001), with more anterior wall MI (62.6% vs 52.1%; P = 0.032). The primary outcome [in-hospital mortality (10.7% vs 11.3%; P = 0.72)] and secondary outcomes [in-hospital complications (29.1% vs 31.7%; P = 0.23) and one-year all-cause mortality (22.3% vs 22.7%; P = 0.85)] were similar in both groups. Addition of suboptimal self-reported sleep duration as a 5th eSMuRF yielded similar results., Conclusions: 25% of first STEMI patients were SMuRF-less. Clinical outcomes of patients without SMuRFs were similar to those with SMuRFs. Suboptimal sleep duration did not account for the risk associated with the SMuRF-less status., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2023 The Author(s).)- Published
- 2023
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27. Antimicrobial evaluation and molecular docking studies of the combined ethanolic extract of Mollugo cerviana and Mukia maderspatana .
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F SR, V VL, M J, A E, and Rajamanickam P
- Abstract
Medicinal plants are considered to be the source of richness in Traditional Medicine. The chosen plants Mollugocerviana (L.) and Mukiamaderas patina. (L.) are commonly used to treat various ailments in traditional medicine. In the present study these two Plants were extracted with Ethanol and were subjected to Phytochemical Analysis to confirm the presence of different Phytochemicals. After phytochemical analysis the antimicrobial efficiency of the Plant extracts were checked against different microbial pathogens. The results confirm that the combined extract of both the plants shows potent activity against selected pathogenic strains. The results clearly indicate that the activity is in a dose dependent manner which is defined as higher the concentration higher the activity. GC-MS analysis of the extracts showed the presence of Ergost-7-en-3-ol. This ligand was docked with TyRs protein of S.aureusi to understand the interactions and predict the affinity and the activity of the potent bioactive molecules. It shows promising interaction with respect to binding poses of interacted complex. From the current study it is proved that the chosen plants are highly loaded with nutrients and can be used as a drug target in future. Further studies are required to confirm the efficiency of the plant extracts., (© 2023 Biomedical Informatics.)
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- 2023
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28. Randomized double-blind, placebo-controlled study of oral gabapentin for prevention of neuropathy in patients receiving paclitaxel.
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Pandey P, Kumar A, Pushpam D, Khurana S, Malik PS, Gogia A, Arunmozhimaran E, Singh MB, Chandran DS, and Batra A
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- Humans, Paclitaxel adverse effects, Gabapentin adverse effects, India, Double-Blind Method, Antineoplastic Combined Chemotherapy Protocols adverse effects, Peripheral Nervous System Diseases chemically induced, Peripheral Nervous System Diseases diagnosis, Peripheral Nervous System Diseases prevention & control, Antineoplastic Agents adverse effects
- Abstract
Background: Peripheral neuropathy is a common dose-limiting side effect of paclitaxel. To date, there is no effective strategy to prevent paclitaxel-induced peripheral neuropathy. A recent small phase II study demonstrated the potential role of oral gabapentin in this setting. This phase III study is aimed to assess the efficacy of oral gabapentin in preventing paclitaxel-induced neuropathy., Objective: To compare the efficacy of oral gabapentin with placebo in preventing clinically significant peripheral neuropathy (NCI CTCAEv5.0 grade 2 or higher) in patients receiving paclitaxel., Methods: This is a randomized, placebo-controlled, double-blind, parallel-group superiority trial. The primary outcome is the development of grade 2 or higher chemotherapy-induced peripheral neuropathy. Secondary outcomes include any grade neuropathy, the percentage change in sensory nerve conduction velocities in peripheral nerves, time to development of any grade neuropathy, paclitaxel dose reductions and delays due to peripheral neuropathy, patient-reported outcomes, adverse events, and adherence to oral therapy. A total of 136 patients receiving paclitaxel will be randomly allocated (stratified by weekly vs. non-weekly administration) to receive either oral gabapentin or placebo till three weeks after the last dose of chemotherapy or occurrence of the primary outcome., Conclusion: This study aims to find if oral gabapentin reduces the incidence of grade 2 or higher chemotherapy-induced peripheral neuropathy in patients receiving paclitaxel., Trial Registration: The trial is registered prospectively with the Clinical Trials Registry of India (CTRI/2022/02/040030) on April 4, 2022., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
29. One-year comparative assessment of retention of arch width increases between modified vacuum-formed and Hawley retainers.
- Author
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Ashari A, Xian L, Syed Mohamed AMF, Wahab RMA, Kit YC, Tata MD, Sinnasamy S, and Kuppusamy E
- Subjects
- Humans, Treatment Outcome, Vacuum, Orthodontic Appliance Design, Orthodontic Retainers
- Abstract
Objectives: To compare the clinical effectiveness of Hawley retainers (HRs) and modified vacuum-formed retainers (mVFRs) with palatal coverage in maintaining transverse expansion during a 12-month retention period., Materials and Methods: Data were collected from postorthodontic treatment patients who met the inclusion criteria. A total of 35 patients were randomly allocated using a centralized randomization technique into either mVFR (n = 18) or HR group (n = 17). The outcome assessor and data analyst were blinded to the retention method. Dental casts of patients were evaluated at debond, 3 months, 6 months, and 12 months of retention. Intercanine width (ICW), interpremolar width (IPMW), interfirst molar mesiobuccal cusp width 1 (IFMW1), and interfirst molar distobuccal cusp width 2 (IFMW2) were compared between groups over time using mixed analysis of variance., Results: No statistically significant differences were found between the two groups for ICW (P = .76), IPMW (P = .63), IFMW1 (P = .16), and IFMW2 (P = .40) during the 12-month retention period., Conclusions: The null hypothesis could not be rejected. HR and mVFR had similar clinical effectiveness in the retention of transverse expansion cases during a 12-month retention period., (© 2022 by The EH Angle Education and Research Foundation, Inc.)
- Published
- 2022
- Full Text
- View/download PDF
30. Long-Term Follow-Up following Condylotomy in a Case of Traumatic Unilateral Anterosuperior Mandibular Condyle Dislocation.
- Author
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Nabil S, Kuppusamy E, Nordin R, Nazimi AJ, and Ramli R
- Abstract
Anterosuperior temporomandibular joint dislocation is rare. Manual reduction of such dislocation is difficult especially when treatment is delayed. Therefore, it has an increased likelihood of needing surgical intervention to achieve reduction. The authors report a case of an anterosuperior temporomandibular dislocation in a 19-year-old male following a motor vehicle accident. Difficulties were encountered in reducing the dislocation necessitating surgically assisted reduction. The long-term outcome following management by condylotomy is reported. This present report also reviews the literature regarding the classification and management of this uncommon dislocation.
- Published
- 2019
- Full Text
- View/download PDF
31. Interceptive Correction of Anterior Crossbite Using Short-Span Wire-Fixed Orthodontic Appliance: A Report of Three Cases.
- Author
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Sockalingam SNMP, Khan KAM, and Kuppusamy E
- Abstract
Anterior crossbite is relatively a common presentation in the mixed dentition stage. If left untreated, it can lead to a host of problems and may complicate future orthodontic treatment. One of the major difficulties in performing anterior crossbite correction in young children is treatment compliance. In most cases, poor compliance is due to the unacceptability of the removable appliance used. This article describes three cases of successful correction of anterior crossbite of patients in mixed dentition using short-span wire-fixed orthodontic appliances. This sectional appliance provides an alternative method of correcting anterior crossbite of dental origin and offers many advantages compared to the use of removable appliances.
- Published
- 2018
- Full Text
- View/download PDF
32. Neuroprotective effect of Clerodendrum serratum Linn. leaves extract against acute restraint stress-induced depressive-like behavioral symptoms in adult mice.
- Author
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Vazhayil BK, Rajagopal SS, Thangavelu T, Swaminathan G, and Rajagounder E
- Subjects
- Animals, Brain metabolism, Chromatography, High Pressure Liquid, Depression drug therapy, Disease Models, Animal, Hindlimb Suspension, Male, Mice, Motor Activity drug effects, Neuroprotective Agents isolation & purification, Oxidative Stress drug effects, Plant Leaves, Restraint, Physical, Serotonin metabolism, Stress, Psychological drug therapy, Swimming, Antidepressive Agents pharmacology, Clerodendrum chemistry, Neuroprotective Agents pharmacology, Plant Extracts pharmacology
- Abstract
Objective: The objective of this study was to study the effect of ethanol extract of Clerodendrum serratum (EECS) Linn. on acute restraint stress (ARS)-induced depressive-like behavior and biochemical alterations in mice., Materials and Methods: Ethyl acetate and n-butanol fractions of EECS were analytically characterized for the flavonoid components, apigenin (API) and luteolin (LUT) by reverse-phase high-performance liquid chromatography. Behavioral tests, namely, forced-swim test and tail-suspension test were performed for assessing antidepressant-like effect and anxiolytic activity in mice. Oxidative stress parameters and biochemical alterations in mice brain tissue were also performed., Statistical Analysis: Expression of data was done as mean ± standard error of mean. The normally distributed data were subjected to two-way ANOVA followed by Dunnett's test. P < 0.05 was considered statistically significant., Results: The study showed that flavonoids, API and LUT were present in ethyl acetate and n-butanol fractions of EECS, which significantly reversed ARS-induced depressive-like behavior without affecting locomotion. EECS also attenuated oxidative damage caused by ARS. The level of norepinephrine and 5-hydroxytryptamine was also significantly restored by pretreatment with EECS for 7 days., Conclusion: EECS significantly alleviated ARS-induced depressive-like behavior without affecting locomotion., Competing Interests: There are no conflicts of interest.
- Published
- 2017
- Full Text
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33. Synthesis of Iron Oxide Micro and Nanoparticles from Aluminum Industry Waste and Its Application in the Decolorization of Reactive Blue 235 Dye.
- Author
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Natarajan E and Ponnaiah GP
- Subjects
- Dose-Response Relationship, Drug, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Spectroscopy, Fourier Transform Infrared, Aluminum, Azo Compounds chemistry, Ferric Compounds chemistry, Industrial Waste, Nanoparticles chemistry
- Abstract
Iron oxide micro and nanoparticles were successfully synthesized from Red Mud (RM) using a simple twostep process. RM was characterized using various techniques such as X-Ray Diffractometer (XRD), Fourier Transform- Infra Red (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX) analysis and Carbon Hydrogen Nitrogen (CHN) microanalysis. Red mud derived iron oxide micro and nanoparticles (RIMNP) were characterized using techniques such as XRD, FTIR, SEM/EDX, Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). RIMNP were employed as a Fenton like catalyst for the decolorization of a commonly used textile dye Reactive Blue 235 (RB235) from aqueous solution. The dynamical data obtained at different concentrations of RIMNP fit well with pseudo-second-order kinetic model and 100% dye removal efficiency was obtained at 200 mg L-1 concentration of RIMNP.
- Published
- 2016
- Full Text
- View/download PDF
34. Abp1 utilizes the Arp2/3 complex activator Scar/WAVE in bristle development.
- Author
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Koch N, Dharmalingam E, Westermann M, Qualmann B, Thomas U, and Kessels MM
- Subjects
- Actin Cytoskeleton chemistry, Actin-Related Protein 2-3 Complex genetics, Actins chemistry, Actins metabolism, Animals, COS Cells, Carrier Proteins genetics, Cell Membrane genetics, Cell Membrane metabolism, Chlorocebus aethiops, Drosophila Proteins genetics, Drosophila melanogaster genetics, Drosophila melanogaster metabolism, Gene Knockout Techniques, HEK293 Cells, Humans, Microfilament Proteins deficiency, Microfilament Proteins genetics, RNA Interference, Signal Transduction, Wiskott-Aldrich Syndrome Protein Family genetics, src Homology Domains, Actin Cytoskeleton metabolism, Actin-Related Protein 2-3 Complex metabolism, Carrier Proteins metabolism, Drosophila Proteins metabolism, Drosophila melanogaster growth & development, Microfilament Proteins metabolism, Wiskott-Aldrich Syndrome Protein Family metabolism
- Abstract
Many developmental processes rely on cortical actin dynamics; however, the mechanisms of its fine control at the cell cortex are still largely unknown. Our analyses demonstrate that the lipid- and F-actin-binding protein Abp1 is crucial for actin-driven bristle development in Drosophila melanogaster. Combined genetic, cell biological and biochemical analyses reveal that Abp1 triggers cortical Arp2/3-mediated actin nucleation by complex formation with Scar in bristle development. The role of the plasma-membrane-associated Abp1 subpool was highlighted by constitutively membrane-anchored Abp1. Such gain-of-function experiments led to a severe split-bristle phenotype, which was negatively correlated with bristle length. This phenotype was dependent on Scar but not on WASP and required the Scar-interacting SH3 domain of Abp1. Strikingly, knockout of abp1 led to defects in both microchaete and macrochaete bristle integrity. Importantly, Arp2- and Scar-deficient flies displayed similar bristle phenotypes. Microchaetes of flies deficient for Abp1, Arp2 and Scar functions had kinks, whereas those of wasp heterozygous flies did not. Electron microscopy analyses revealed that abp1 knockout, Arp2 RNAi and Scar RNAi all led to distorted macrochaetes with an excessive number of ridges. Interestingly, despite the physical association of Abp1 with Scar and its ability to use the Arp2/3 complex activator as an effector, abp1 knockout did not affect Scar stability. This is in contrast to classical Scar complex components, such as Kette or Sra-1. Our work reveals that Abp1 is an important, Scar-interacting factor controlling cortical Arp2/3-mediated actin nucleation and unravels a novel layer of complexity in the scrupulous control of cortical actin nucleation during sensory organ formation.
- Published
- 2012
- Full Text
- View/download PDF
35. F-BAR proteins of the syndapin family shape the plasma membrane and are crucial for neuromorphogenesis.
- Author
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Dharmalingam E, Haeckel A, Pinyol R, Schwintzer L, Koch D, Kessels MM, and Qualmann B
- Subjects
- Actin-Related Protein 2-3 Complex metabolism, Actins metabolism, Animals, Animals, Newborn, Carrier Proteins chemistry, Cell Line, Transformed, Chlorocebus aethiops, Conserved Sequence, Cytoskeletal Proteins, Dendrites physiology, Embryo, Mammalian, Endocytosis genetics, Endosomes metabolism, Hippocampus cytology, Humans, Liposomes, Microtubule-Associated Proteins metabolism, Mutation genetics, Phosphatidylinositol 4,5-Diphosphate metabolism, RNA, Small Interfering genetics, RNA, Small Interfering metabolism, Rats, Rats, Wistar, Subcellular Fractions metabolism, Transfection methods, cdc42 GTP-Binding Protein metabolism, Carrier Proteins metabolism, Cell Membrane physiology, Neurons cytology, Wiskott-Aldrich Syndrome Protein, Neuronal metabolism
- Abstract
Coordinated functions of the actin cytoskeleton and microtubules, which require careful control in time and space, are indispensable for the drastic alterations of neuronal morphology during neuromorphogenesis and neuronal network formation. Actin filament formation driven by the Arp2/3 complex and its activator neural Wiskott-Aldrich syndrome protein (N-WASP) is important for proper axon development. The underlying molecular mechanisms for targeting to and specific activation of N-WASP at the neuronal plasma membrane, however, have thus far remained elusive. We show that syndapin I is critical for proper neuromorphogenesis and hereby uses N-WASP as a cytoskeletal effector. Upon N-WASP binding, syndapins release N-WASP autoinhibition. Syndapins hereby cooperate with Cdc42 and phosphatidyl-inositol-(4,5)-bisphosphate. Syndapins furthermore specifically bind to phosphatidylserine-containing membranes via their extended F-BAR domain. Dissecting the syndapin functions actin nucleation and direct membrane binding in vivo, we demonstrate that both functions are physiologically relevant and required. Constitutive plasma membrane-targeting experiments in vivo indicate that specifically actin nucleation at the cell cortex is triggered by syndapins. Consistent with syndapins steering N-WASP as downstream effector for cortical actin nucleation, syndapin-induced neuronal arborization is N-WASP and Cdc42 dependent. The functions of syndapin-N-WASP complexes in neuromorphogenesis were revealed by loss-of-function studies. Knockdown of syndapin I leads to impaired axon development and especially phenocopies the aberrant axon branching observed upon N-WASP and Arp2/3 complex deficiency. In contrast, proper length control involves another N-WASP-binding protein, Abp1. Our data thus reveal that syndapin I is crucial for neuromorphogenesis and that different N-WASP activators ensure fine control of N-WASP activity and have distinct functions during neuronal network formation.
- Published
- 2009
- Full Text
- View/download PDF
36. Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE.
- Author
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Fricke R, Gohl C, Dharmalingam E, Grevelhörster A, Zahedi B, Harden N, Kessels M, Qualmann B, and Bogdan S
- Subjects
- Actins metabolism, Actins physiology, Animals, Biological Transport, Body Patterning, Carrier Proteins genetics, Carrier Proteins metabolism, Drosophila cytology, Drosophila Proteins genetics, Dynamins metabolism, Dynamins physiology, Endocytosis, Endosomes metabolism, Endosomes physiology, GTP-Binding Proteins metabolism, GTP-Binding Proteins physiology, Gene Dosage, Models, Biological, Wings, Animal anatomy & histology, Wings, Animal growth & development, Carrier Proteins physiology, Drosophila metabolism, Drosophila Proteins metabolism, Drosophila Proteins physiology, Microfilament Proteins metabolism, Wiskott-Aldrich Syndrome Protein metabolism
- Abstract
Background: Developmental processes are intimately tied to signaling events that integrate the dynamic reorganization of the actin cytoskeleton and membrane dynamics. The F-BAR-domain-containing proteins are prime candidates to couple actin dynamics and membrane trafficking in different morphogenetic processes., Results: Here, we present the functional analysis of the Drosophila F-BAR protein Cip4/Toca1 (Cdc42-interacting protein 4/transducer of Cdc42-dependent actin assembly 1). Cip4 is able to form a complex with WASP and SCAR/WAVE and recruits both actin-nucleation-promoting factors to invaginating membranes and endocytic vesicles. Actin-comet-tail-based movement of these vesicles depends not only on WASP but largely on WAVE function. In vivo, loss of cip4 function causes multiple wing hairs. A similar phenotype is observed when vesicle scission is affected after Dynamin suppression. Gene dosage experiments show that Cip4 and WAVE functionally interact to restrict wing hair formation. Further rescue experiments confirm that Cip4 is able to act through WAVE and WASP in vivo. Biochemical and functional data support a model in which Cdc42 acts upstream of Cip4 and recruits not only WASP but also SCAR/WAVE via Abi to control Dynamin-dependent cell polarization in the wing., Conclusion: Cip4 integrates membrane trafficking and actin dynamics through WASP and WAVE. First, Cip4 promotes membrane invaginations and triggers the vesicle scission by recruiting Dynamin to the neck of nascent vesicles. Second, Cip4 recruits WASP and WAVE proteins to induce actin polymerization, supporting vesicle scission and providing the force for vesicle movement.
- Published
- 2009
- Full Text
- View/download PDF
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