1. Evaluation of bone substitute materials: comparison of flat-panel based volume CT to conventional multidetector CT
- Author
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Christian Scheifele, P. A. Ganter, Moritz Palmowski, Egle Veigel, Jörg Haberstroh, Pit Jacob Voss, Taskin Tuna, Jörg Smedek, Ralf Gutwald, Sebastian Sauerbier, Fabian Duttenhoefer, Elefterios Sachlos, and Karl-Thomas Wrbas
- Subjects
medicine.medical_specialty ,Time Factors ,Maxillary sinus ,Dynamic imaging ,Cell Culture Techniques ,Sinus Floor Augmentation ,Multidetector ct ,Bone remodeling ,Random Allocation ,Imaging, Three-Dimensional ,Tissue engineering ,Bone Density ,Apatites ,Multidetector Computed Tomography ,medicine ,Image Processing, Computer-Assisted ,Animals ,Bone regeneration ,Autografts ,Osteoblasts ,Sheep ,Tissue Engineering ,Tissue Scaffolds ,business.industry ,Maxillary Sinus ,Drug Combinations ,medicine.anatomical_structure ,Otorhinolaryngology ,Bone Substitutes ,Surgery ,Radiology ,Bone Remodeling ,Collagen ,Oral Surgery ,business ,Tomography, X-Ray Computed ,Preclinical imaging ,Biomedical engineering ,Volume (compression) - Abstract
Over the last decade tissue engineering has emerged as a key factor in bone regeneration within the field of cranio-maxillofacial surgery. Despite this in vivo analysis of tissue-engineered-constructs to monitor bone rehabilitation are difficult to conduct. Novel high-resolving flat-panel based volume CTs (fp-VCT) are increasingly used for imaging bone structures. This study compares the potential value of novel fp-VCT with conventional multidetector CT (MDCT) based on a sheep sinus floor elevation model. Calcium-hydroxyapatite reinforced collagen scaffolds were populated with autologous osteoblasts and implanted into sheep maxillary sinus. After 8, 16 and 24 weeks MDCT and fp-VCT scans were performed to investigate the volume of the augmented area; densities of cancellous and compact bone were assessed as comparative values. fp-VCT imaging resulted in higher spatial resolution, which was advantageous when separating closely related anatomical structures (i.e. trabecular and compact bone, biomaterials). Fp-VCT facilitated imaging of alterations occurring in test specimens over time. fp-VCTs therefore displayed high volume coverage, dynamic imaging potential and superior performance when investigating superfine bone structures and bone remodelling of biomaterials. Thus, fp-VCTs may be a suitable instrument for intraoperative imaging and future in vivo tissue-engineering studies.
- Published
- 2012