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Evaluation of bone substitute materials: comparison of flat-panel based volume CT to conventional multidetector CT
- Source :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 41(7)
- Publication Year :
- 2012
-
Abstract
- Over the last decade tissue engineering has emerged as a key factor in bone regeneration within the field of cranio-maxillofacial surgery. Despite this in vivo analysis of tissue-engineered-constructs to monitor bone rehabilitation are difficult to conduct. Novel high-resolving flat-panel based volume CTs (fp-VCT) are increasingly used for imaging bone structures. This study compares the potential value of novel fp-VCT with conventional multidetector CT (MDCT) based on a sheep sinus floor elevation model. Calcium-hydroxyapatite reinforced collagen scaffolds were populated with autologous osteoblasts and implanted into sheep maxillary sinus. After 8, 16 and 24 weeks MDCT and fp-VCT scans were performed to investigate the volume of the augmented area; densities of cancellous and compact bone were assessed as comparative values. fp-VCT imaging resulted in higher spatial resolution, which was advantageous when separating closely related anatomical structures (i.e. trabecular and compact bone, biomaterials). Fp-VCT facilitated imaging of alterations occurring in test specimens over time. fp-VCTs therefore displayed high volume coverage, dynamic imaging potential and superior performance when investigating superfine bone structures and bone remodelling of biomaterials. Thus, fp-VCTs may be a suitable instrument for intraoperative imaging and future in vivo tissue-engineering studies.
- Subjects :
- medicine.medical_specialty
Time Factors
Maxillary sinus
Dynamic imaging
Cell Culture Techniques
Sinus Floor Augmentation
Multidetector ct
Bone remodeling
Random Allocation
Imaging, Three-Dimensional
Tissue engineering
Bone Density
Apatites
Multidetector Computed Tomography
medicine
Image Processing, Computer-Assisted
Animals
Bone regeneration
Autografts
Osteoblasts
Sheep
Tissue Engineering
Tissue Scaffolds
business.industry
Maxillary Sinus
Drug Combinations
medicine.anatomical_structure
Otorhinolaryngology
Bone Substitutes
Surgery
Radiology
Bone Remodeling
Collagen
Oral Surgery
business
Tomography, X-Ray Computed
Preclinical imaging
Biomedical engineering
Volume (compression)
Subjects
Details
- ISSN :
- 18784119
- Volume :
- 41
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
- Accession number :
- edsair.doi.dedup.....9bff637e677074125199895acbb74567