91 results on '"Eduardo Garcia-Pachon"'
Search Results
2. Environmental Microplastics in the Lower Airway of Shoe Manufacturing Workers
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Carlos Baeza-Martínez, Lucía Zamora-Molina, Eduardo Garcia-Pachon, Mar Masiá, Luis Hernandez-Blasco, and Javier Bayo
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Diseases of the respiratory system ,RC705-779 - Published
- 2022
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3. Prediction of Three-Month Readmission Based on Haematological Parameters in Patients with Severe COPD Exacerbation
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Justo Grau-Delgado, Eduardo Garcia-Pachon, Sandra Ruiz-Alcaraz, and Carlos Baeza-Martinez
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Exacerbation ,Patient Readmission ,Pulmonary Disease, Chronic Obstructive ,Internal medicine ,Humans ,Medicine ,In patient ,Prospective Studies ,Mean platelet volume ,Neutrophil to lymphocyte ratio ,Prospective cohort study ,Aged ,COPD ,business.industry ,Area under the curve ,Red blood cell distribution width ,Middle Aged ,medicine.disease ,Blood Cell Count ,Disease Progression ,Female ,business ,Biomarkers - Abstract
Introduction: Approximately one-third of patients hospitalised for an exacerbation of chronic obstructive pulmonary disease (COPD) are readmitted to the hospital within 90 days. It is of interest to identify biomarkers that predict relapse in order to prevent readmission in these patients. In our prospective study of patients admitted for COPD exacerbation, we aimed to analyse whether routine haematological parameters can help predict the three-month readmission risk. Material and methods: 106 patients were included, of whom 23 were female (22%). The age (mean ± SD) was 73 ± 10 years, and the forced expiratory volume in 1 second (FEV1) was 44 ± 15%. The haematological parameters were obtained from the first blood test result during admission. The variables were as follows: red cell distribution width, mean platelet volume (MPV), platelet (PLT) count, neutrophil to lymphocyte ratio, PLT to lymphocyte ratio, MPV to PLT ratio, and eosinophil count. Patients were differentiated into two groups for each haematological parameter according to median value, and the percentage of readmissions in each of the groups was recorded. Results: Twenty-five patients (24%) were readmitted to hospital within three months of discharge. Only the difference in low-MPV and high-MPV patients was significant (37% vs. 10%, p = 0.001). The predictive capacity for three-month readmission measured by the area under the curve (AUC) did not show clinically applicable values; the best result was for MPV (AUC 0.64). In the remaining values, the AUC was between 0.52 and 0.55. Conclusion: Routine haematological parameters proposed as prognostic biomarkers in COPD obtained at the moment of hospital admission were not useful for predicting three-month readmission.
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- 2021
4. Environmental Microplastics and the Lung
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Carlos Baeza-Martínez, Eduardo Garcia-Pachon, and Javier Bayo
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Pulmonary and Respiratory Medicine - Published
- 2022
5. Low prevalence of post-COVID-19 syndrome in patients with asthma
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Lucía Zamora-Molina, Isabel Padilla-Navas, Justo Grau-Delgado, Maria J. Soler-Sempere, Eduardo Garcia-Pachon, Sandra Ruiz-Alcaraz, and Carlos Baeza-Martinez
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Microbiology (medical) ,2019-20 coronavirus outbreak ,Hot Temperature ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Carbazoles ,Molecular Conformation ,Antineoplastic Agents ,medicine.disease_cause ,Mice ,Structure-Activity Relationship ,medicine ,Animals ,In patient ,Letter to the Editor ,Asthma ,Coronavirus ,DNA, Superhelical ,business.industry ,DNA ,medicine.disease ,Virology ,Intercalating Agents ,Infectious Diseases ,Mice, Inbred DBA ,Symptoms ,business - Abstract
Ditercalinium (2,2'-([4,4'-bipiperidine-1,1'-diyl] di-2,1-ethane diyl) bis (10-methoxy-7H-pyrido[4,3c] carbazolium) tetra(methyl sulphonate--NSC 366241), a DNA bis-intercalating compound presently under clinical trial, elicits an original mechanism of action and thus appears as the first of a new class of anti-tumour drugs. Previous studies have shown that a reduced flexibility of the linking chain of these dimers is essential for their biological activity. In order to analyze their mechanism of action at the molecular level and to obtain structure-activity relationships in this series, new derivatives with additional methylene groups between the two piperidine rings have been synthesized. Whereas the addition of a single methylene group in the chain preserves the anti-tumour activity of the dimers, the addition of a second methylene diminishes it; the addition of three methylenes completely abolishes it. Lengthening of sonicated DNA and unwinding of supercoiled DNA support a bis-intercalation mechanism for these drugs. In addition, analyses of poly d(A-T) melting curves in the presence of the drugs, and competition experiments with ethidium dimer, show that these compounds bind to DNA with high affinity (10(7)-10(8) M-1). N.m.r. studies of the dimers in aqueous medium show that the introduction of a single methylene group in the linker leads to compounds with a conformationally-induced decrease of intermolecular stacking interactions, which might be related to the DNA affinity enhancement observed for these dimers. Different hypotheses concerning structure-activity relationships in the different series are discussed.
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- 2021
6. Derrame pleural por carcinoma de células de Merkel
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Isabel Padilla-Navas, María Cabezas-Macián, María O Alvárez-Fernández, Jose F. Sanchez-Hernandez, Eduardo Garcia-Pachon, and Maria J. Soler-Sempere
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Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Merkel cell carcinoma ,business.industry ,Pleural effusion ,medicine ,MEDLINE ,medicine.disease ,business - Published
- 2021
7. Asthma and COPD in hospitalized COVID-19 patients
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Carlos Baeza-Martinez, Eduardo Garcia-Pachon, Félix Gutiérrez, Lucía Zamora-Molina, Isabel Padilla-Navas, Justo Grau-Delgado, and Maria J. Soler-Sempere
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Pulmonary and Respiratory Medicine ,Male ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Pulmonary disease ,Comorbidity ,Article ,Betacoronavirus ,Pulmonary Disease, Chronic Obstructive ,Internal medicine ,Prevalence ,Humans ,Medicine ,Pandemics ,Aged ,Asthma ,Gynecology ,Aged, 80 and over ,COPD ,SARS-CoV-2 ,business.industry ,COVID-19 ,General Medicine ,Middle Aged ,medicine.disease ,Hospitalization ,Pneumonia ,Spain ,Female ,Coronavirus Infections ,business - Published
- 2020
8. Oportunidades perdidas en la detección de la tuberculosis: análisis de las visitas a Urgencias antes del diagnóstico
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Justo Grau-Delgado, Maria J. Soler-Sempere, E. Nofuentes-Pérez, J.A. Gutiérrez-Navarro, Eduardo Garcia-Pachon, and Lucía Zamora-Molina
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,Medicine ,030212 general & internal medicine ,General Medicine ,business ,Humanities - Abstract
Resumen Objetivo Evaluar en pacientes diagnosticados de tuberculosis pulmonar la frecuencia de asistencias en Urgencias en los 6 meses previos al diagnostico, conocer los motivos de la asistencia, el grado de sospecha en Urgencias y los factores a los que se asociaba esta sospecha. Metodo Estudio retrospectivo de los casos de tuberculosis pulmonar atendidos en un servicio de Urgencias generales entre 2011 y 2017. Resultados De los 54 pacientes incluidos, 38 (70%) habian sido atendidos en el servicio de Urgencias en los 6 meses previos al diagnostico: 6 (16%) por procesos sin relacion con la tuberculosis y 32 (84%) con relacion potencial. En 12 (38%) de estos pacientes se sospecho en Urgencias la posibilidad del diagnostico de tuberculosis pulmonar, y no se sospecho en los restantes 20 pacientes (62%). El grupo en el que se sospecho tenia mas frecuencia de sintomas generales y respiratorios y mas frecuencia de cavitacion en la radiografia. Conclusiones Un elevado porcentaje de pacientes con tuberculosis pulmonar han consultado en Urgencias en los 6 meses previos al diagnostico, y con mucha frecuencia esta posibilidad diagnostica no se sospecha.
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- 2019
9. Missed opportunities for detecting tuberculosis: An analysis of emergency department visits before the diagnosis
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Lucía Zamora-Molina, J.A. Gutiérrez-Navarro, Eduardo Garcia-Pachon, E. Nofuentes-Pérez, Justo Grau-Delgado, and Maria J. Soler-Sempere
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medicine.medical_specialty ,Tuberculosis ,business.industry ,Retrospective cohort study ,General Medicine ,Emergency department ,medicine.disease ,humanities ,03 medical and health sciences ,0302 clinical medicine ,Pulmonary tuberculosis ,Emergency medicine ,medicine ,030212 general & internal medicine ,business ,General Emergency Department - Abstract
Objective To assess the frequency of care in an emergency department in the 6 months prior to the diagnosis of tuberculosis and to determine the reasons for the care, the degree of suspicion in the emergency department and the factors associated with this suspicion. Method A retrospective study was conducted on patients with pulmonary tuberculosis treated in the general emergency department between 2011 and 2017. Results Of the 54 included patients, 38 (70%) had been treated in the emergency department in the 6 months prior to the diagnosis: 6 (16%) patients had been treated for processes unrelated to the tuberculosis, and 32 (84%) were treated for processes that were potentially related to the tuberculosis. Pulmonary tuberculosis was suspected in the emergency department for 12 (38%) of these patients and not suspected in the remaining 20 patients (62%). The group in which pulmonary tuberculosis was suspected had a higher rate of general and respiratory symptoms and cavitation in the radiography. Conclusions A high percentage of patients with pulmonary tuberculosis were admitted to the emergency department in the 6 months prior to the diagnosis, and this diagnostic possibility was often not suspected.
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- 2019
10. Lower Airway Microbiota and Lung Cancer
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Lucía Zamora-Molina, Víctor Manuel Barberá, Victoria Sánchez-Hellín, Justo Grau-Delgado, Maria J. Soler-Sempere, Antonio Galiana, Isabel Padilla-Navas, and Eduardo Garcia-Pachon
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medicine.diagnostic_test ,business.industry ,medicine.disease ,Applied Microbiology and Biotechnology ,Microbiology ,DNA sequencing ,Bronchoscopy ,Immunology ,medicine ,Microbiome ,Lung cancer ,Airway ,business ,Biotechnology - Published
- 2019
11. Symptoms in patients with asthma infected by SARS-CoV-2
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Justo Grau-Delgado, Maria J. Soler-Sempere, Carlos Baeza-Martinez, Lucía Zamora-Molina, Eduardo Garcia-Pachon, Sandra Ruiz-Alcaraz, and Isabel Padilla-Navas
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Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Exacerbation ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Short Communication ,Disease ,Comorbidity ,Asymptomatic ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,030212 general & internal medicine ,Asthma ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,COVID-19 ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Virus ,Pneumonia ,medicine.anatomical_structure ,030228 respiratory system ,Female ,medicine.symptom ,business ,Respiratory tract - Abstract
Introduction Organ tropism of SARS-CoV-2 to the respiratory tract could potentially aggravate asthma. The susceptibility of patients with asthma to develop an exacerbation when they are infected with SARS-CoV-2 is unknown. We aimed to investigate the symptoms presented in patients with asthma who became infected with SARS-CoV-2. Methods and results All patients over 14 years of age who tested positive for SARS-CoV-2 (by RT-PCR) were included (n = 2995). In patients with asthma (n = 77, 2.6%; 44 females), symptoms, therapy and phenotype were recorded. Seventeen (22%) patients had mild asthma, 55 (71%) moderate and five severe (6%). Twenty-six patients with asthma (34%) were asymptomatic, 34 (44%) developed symptoms but did not require hospital admission, and 17 (22%) were hospitalised. One patient was admitted because of asthma exacerbation without pneumonia or other symptoms. Ten patients (13%) had wheezes (six with pneumonia). Comparison of wheezing between patients with non-T2 asthma and the rest of the patients was statistically significant, (p Conclusions SARS-CoV-2 infection is not a significant cause of asthma exacerbation, although some patients may present wheezing, especially in cases of pneumonia. The severity of asthma does not seem to be associated with symptoms of the disease.
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- 2021
12. Respiramos plástico: detección de microplásticos en el sistema respiratorio humano
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Javier Bayo, Carlos Baeza-Martínez, Miguel Gonzáez-Pleiter, Eduardo García-Pachón, Joaquín López-Castellanos, Marta Doval, Asunción Guillén, and Carmen María Vidal
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microplásticos ,microfibras ,lavado broncoalveolar ,exposición ambiental ,pulmón ,salud pública ,Medicine - Abstract
Se han detectado microplásticos en todos los compartimentos ambientales, incluida la atmósfera, aunque, de momento, pocos estudios los han investigado en el tracto respiratorio humano. En este artículo recogemos los resultados del análisis de microfibras plásticas en la vía aérea inferior de 44 pacientes adultos con distintas patologías respiratorias, empleando para ello el fluido obtenido del lavado broncoalveolar como método mínimamente invasivo. Se ha estudiado la relación entre hábitos de vida y parámetros fisiológicos y médicos de los pacientes y sus concentraciones en microfibras plásticas aisladas del tracto respiratorio Los resultados mostraron una concentración media de microfibras plásticas de 9,18 ± 2,45 MF/100 ml BAL, con un tamaño medio de 1,73 ± 0,15 mm y una dimensión máxima de 9,96 mm, correspondiente a una fibra poliacrílica. Aparecieron diferencias estadísticamente significativas con el sexo, la edad, el hábito tabáquico, el tipo de ocupación y el diagnóstico por rayos X del paciente, entre otras. Se hacen necesarios más estudios para dilucidar los efectos negativos que estos microcontaminantes pueden tener sobre el sistema respiratorio humano y sus enfermedades asociadas.
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- 2024
13. Platelet-to-Lymphocyte Ratio and Survival in Malignant Pleural Effusion
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Lucía Zamora-Molina, Justo Grau-Delgado, Maria J. Soler-Sempere, Eduardo Garcia-Pachon, Isabel Padilla-Navas, and Carlos Baeza-Martinez
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Blood Platelets ,Male ,medicine.medical_specialty ,Receiver operating characteristic ,business.industry ,medicine.medical_treatment ,Lymphocyte ,Thoracentesis ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,Pleural Effusion, Malignant ,body regions ,medicine.anatomical_structure ,ROC Curve ,Biomarkers, Tumor ,Medicine ,Malignant pleural effusion ,Humans ,Platelet ,In patient ,Female ,Radiology ,Cutoff point ,Lymphocytes ,business - Abstract
Background Efforts have been made to search for parameters that facilitate the prediction of the 3-month survival for clinical decisions in patients with malignant pleural effusion (MPE). We sought to evaluate whether the platelet-to-lymphocyte ratio (PLR) may be a useful marker of 3-month survival in a series of consecutive patients with MPE. Methods A total of 81 patients with MPE were included, 46 (57%) of whom were female. Twenty-six patients (32%) died during the first 3 months according to thoracentesis data. Results The area under the receiver operating characteristics curve was 0.73 for PLR. Using a cutoff point of 158, patients with higher PLR values experienced higher mortality at 3 months (p = 0.001). Conclusions PLR was able to successfully differentiate patients with different survival at 3 months. Outcomes of the PLR (a fast and inexpensive test) could be included among the prognostic factors able to guide the personalized management of MPE.
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- 2020
14. Asthma prevalence in patients with SARS-CoV-2 infection detected by RT-PCR not requiring hospitalization
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Lucía Zamora-Molina, Vicente Canto-Reig, Justo Grau-Delgado, Carlos Baeza-Martinez, Isabel Padilla-Navas, Maria J. Soler-Sempere, Nieves Gonzalo-Jiménez, Eduardo Garcia-Pachon, Antonio Ramon-Sanchez, and Montserrat Ruiz-García
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Comorbidity ,Risk Assessment ,Article ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,COVID-19 Testing ,Risk Factors ,Internal medicine ,medicine ,Prevalence ,Humans ,In patient ,030212 general & internal medicine ,Anti-Asthmatic Agents ,skin and connective tissue diseases ,Pandemics ,Asthma ,Retrospective Studies ,Asthma exacerbations ,business.industry ,Clinical Laboratory Techniques ,SARS-CoV-2 ,fungi ,COVID-19 ,Retrospective cohort study ,Asthma symptoms ,Middle Aged ,medicine.disease ,respiratory tract diseases ,body regions ,Coronavirus ,Hospitalization ,Real-time polymerase chain reaction ,030228 respiratory system ,Spain ,Female ,Symptom Assessment ,business ,Coronavirus Infections - Abstract
Introduction The prevalence of asthma in patients hospitalized with SARS-CoV-2 has been studied and varies widely in the different series. However, the prevalence in SARS-infected patients not requiring hospitalization is not known. The objective of this study was to analyze the presence of asthma in a consecutive series of patients who tested positive in the RT-PCR assay for SARS-CoV-2 and did not require hospital admission. Methods and results A total of 218 patients (58% of those who tested positive) did not require hospitalization; they had a median age of 45 years (IQR 34–57) and 57% were female. Six patients (2.8%) had a previous diagnosis of asthma. Only one patient developed a mild aggravation of asthma symptoms associated with SARS-CoV-2 infection. Conclusions Few patients with asthma were infected by SARS-CoV-2, and this infection was not a significant cause of asthma exacerbation.
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- 2020
15. Predictive factors for cardiac conduction abnormalities with hydroxychloroquine-containing combinations for COVID-19
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Carolina Ding, Mar Masiá, Lucía Guillén, Antonia Mora, Sergio Padilla, Guillermo Telenti, Javier García-Abellán, Félix Gutiérrez, Eduardo Garcia-Pachon, and José A. García
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0301 basic medicine ,Male ,Neutrophils ,Lopinavir/ritonavir ,Azithromycin ,Lopinavir ,0302 clinical medicine ,Anti-Infective Agents ,Troponin I ,Pharmacology (medical) ,030212 general & internal medicine ,Lymphocytes ,Prospective cohort study ,General Medicine ,Middle Aged ,Prognosis ,Troponin ,Drug Combinations ,Intensive Care Units ,Long QT Syndrome ,Infectious Diseases ,Treatment Outcome ,Cardiology ,cardiovascular system ,Disease Progression ,Female ,Coronavirus Infections ,medicine.drug ,circulatory and respiratory physiology ,Hydroxychloroquine ,Microbiology (medical) ,QT interval ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,030106 microbiology ,Pneumonia, Viral ,Torsades de pointes ,Article ,03 medical and health sciences ,Betacoronavirus ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Pandemics ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Ritonavir ,business.industry ,SARS-CoV-2 ,COVID-19 ,Retrospective cohort study ,medicine.disease ,business ,Biomarkers - Abstract
Highlights • Hydroxychloroquine (HCQ) has been widely used to treat COVID-19 worldwide even without good evidence of efficacy. • We analyzed the changes occurring in the QTc interval and their predictors in patients treated with HCQ-containing regimens for COVID-19. • Evidence of myocardial injury with elevated troponin and strong inflammatory response, specifically higher neutrophil-to-lymphocyte ratio, were major contributors to moderate-to-severe QTc prolongation requiring careful QTc interval monitoring. • In this closely screened and monitored cohort, no complications derived from QTc prolongation were observed., This longitudinal, prospective cohort study aimed to assess risk of QTc interval prolongation and its predicting factors in subjects treated with combinations containing hydroxychloroquine (HCQ) for COVID-19. Moderate-to-severe QTc prolongation during therapy was defined as a QTc interval >470 ms in men or >480 ms in women. Patients were treated under strict cardiac supervision. A total of 105 adults were included [56% male; median (IQR) age 69 (57–79) years]. All patients received therapy with HCQ in combination with azithromycin (AZM), and 95 (90%) also with lopinavir/ritonavir (LPV/r). Concomitant medications classified as having risk of developing torsades de pointes (TdP) were simultaneously used in 81 patients (77%). Moderate-to-severe QTc prolongation was observed in 14 patients (13%), mostly at Days 3–5 from baseline, with 6 (6%) developing severe prolongation (>500 ms). There was no evidence of TdP arrhythmia or TdP-associated death. Adding LPV/r to HCQ+AZM did not significantly prolong the QTc interval. Multivariable Cox regression revealed that comedications with known risk of TdP (HR = 11.28, 95% CI 1.08–117.41), higher neutrophil-to-lymphocyte (NLR) ratio (HR = 1.10, 95% CI 1.03–1.18 per unit increase) and higher serum hs-cardiac troponin I (HR = 4.09, 95% CI 1.36–12.2 per unit increase) were major contributors to moderate-to-severe QTc prolongation. In this closely screened and monitored cohort, no complications derived from QTc prolongation were observed during pharmacological therapy containing HCQ for COVID-19. Evidence of myocardial injury with elevated troponin and strong inflammatory response, specifically higher NLR, are conditions requiring careful QTc interval monitoring.
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- 2020
16. Prognostic Value of Hematological Inflammatory Markers in Patients with Pleural Effusion Due to Heart Failure
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Carlos Baeza-Martinez, Eduardo Garcia-Pachon, Isabel Padilla-Navas, Lucía Zamora-Molina, Paula Cerda-Guilabert, Justo Grau-Delgado, and Maria J. Soler-Sempere
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Male ,medicine.medical_specialty ,Pleural effusion ,medicine.medical_treatment ,Thoracentesis ,pleural transudate ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Interquartile range ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Mean platelet volume ,prognostic factor ,Survival analysis ,Aged ,Aged, 80 and over ,Heart Failure ,business.industry ,Proportional hazards model ,biomarkers ,medicine.disease ,Prognosis ,mortality ,Pleural Effusion ,Predictive value of tests ,Heart failure ,Female ,business ,Biomarkers - Abstract
Background: Pleural effusions due to heart failure are associated with a high 1-year mortality. Several hematological parameters have been shown to provide prognostic information in patients with cardiovascular diseases. The objective was to assess whether hematological markers can also provide prognostic information in patients with pleural effusion caused by heart failure. Methods: This was a retrospective study of patients with pleural effusion due to heart failure who underwent a diagnostic thoracentesis. The hematological parameters evaluated were as follows: neutrophils, lymphocytes, neutrophil-to-lymphocyte ratio, platelet count, platelet-to-lymphocyte ratio, mean platelet volume (MPV), and MPV-to-platelet ratio. Patients were divided into two groups: those who died within 1 year and survivors of more than 1 year. Differences and possible correlations were analyzed with non-parametric tests. Diagnostic values were estimated. Survival analysis was performed using the Kaplan-Meier method. Cox regression analysis was performed to identify independent variables. Results: Twenty five of 55 (45%) patients died within 1-year from thoracentesis. Patients who died in this period were older, aged 83 years (73 - 87, median and interquartile range, IQR) vs. 74 (65 - 82); with lower platelet count: 181 x 10(3) (140 - 258 x 10(3)) vs. 241 x 10(3) (198 - 324 x 10(3)); and higher MPV/platelet: 48.1 (34.9 - 75.6) vs. 35.6 (27.1 - 42.9). In the regression analysis only the MPV/platelet had statistical significance (p = 0.002). MPV/platelet > 50 had a specificity of 87% for 1-year mortality, and a ratio > 30 had a sensitivity of 84%. Conclusions: Simple hematological parameters such as platelet count and MPV/platelet, may provide useful prognostic information for predicting 1-year mortality in patients with pleural effusion due to heart failure.
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- 2020
17. The Lower Airway Microbiome and Lung Cancer
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Isabel Padilla-Navas and Eduardo Garcia-Pachon
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business.industry ,MEDLINE ,Medicine ,General Medicine ,Microbiome ,Respiratory system ,Bioinformatics ,business ,Airway ,Lung cancer ,medicine.disease - Published
- 2019
18. Acoustic analysis of vowels in patients with sleep apnea syndrome in sitting and supine positions
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Eduardo Garcia-Pachon, Luis Hernandez-Blasco, and Lucía Zamora-Molina
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medicine.medical_specialty ,Supine position ,Neurology ,business.industry ,Sleep apnea ,medicine.disease ,Sitting ,Otorhinolaryngology ,medicine ,Physical therapy ,In patient ,Neurology (clinical) ,business - Published
- 2021
19. Reduction in Hospital Admissions for COPD Exacerbation During the Covid-19 Pandemic
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Carlos Baeza-Martinez, Lucía Zamora-Molina, Eduardo Garcia-Pachon, Maria J. Soler-Sempere, and Jorge Olea-Soto
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lcsh:RC705-779 ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Copd exacerbation ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pandemic ,Emergency medicine ,medicine ,lcsh:Diseases of the respiratory system ,business ,Article - Published
- 2020
20. Comparison between blood gas analyzer and central laboratory analyzer for the determination of electrolytes in patients with acute respiratory acidosis
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Eduardo Garcia-Pachon, Eduardo Garcia-Padilla, Isabel Padilla-Navas, Justo Grau-Delgado, Maria J. Soler-Sempere, Jose F. Sanchez-Hernandez, and Lucía Zamora-Molina
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Spectrum analyzer ,business.industry ,Blood gas analyzer ,Biochemistry (medical) ,Clinical Biochemistry ,Acute respiratory acidosis ,030209 endocrinology & metabolism ,General Medicine ,Electrolyte ,medicine.disease ,030218 nuclear medicine & medical imaging ,Central laboratory ,03 medical and health sciences ,Respiratory acidosis ,0302 clinical medicine ,Anesthesia ,medicine ,In patient ,business - Published
- 2018
21. Gender differences in the authorship of articles in Archivos de Bronconeumología
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Eduardo Garcia-Pachon and Isabel Padilla-Navas
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Anthropology ,business.industry ,Medicine ,General Medicine ,business - Published
- 2021
22. Diferencia de género en la autoría de artículos en Archivos de Bronconeumología
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Eduardo Garcia-Pachon and Isabel Padilla-Navas
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Pulmonary and Respiratory Medicine ,business.industry ,Medicine ,business ,Humanities - Published
- 2021
23. Microbioma de la vía aérea inferior y cáncer de pulmón
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Eduardo Garcia-Pachon and Isabel Padilla-Navas
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Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,business - Published
- 2020
24. Análisis del líquido pleural: parámetros bioquímicos de uso infrecuente
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Jose F. Sanchez-Hernandez, Maria J. Soler-Sempere, Marina Pellicer-Mas, and Eduardo Garcia-Pachon
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03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,030220 oncology & carcinogenesis ,Biochemistry (medical) ,Clinical Biochemistry - Abstract
Resumen El estudio bioquimico del liquido pleural es, con frecuencia, fundamental para el diagnostico de la etiologia del derrame. Existen parametros basicos que aportan informacion relevante de forma inmediata (pH, glucosa, proteinas, lactato deshidrogenasa, adenosina desaminasa). Pero tambien existen otras magnitudes bioquimicas que pueden permitir el diagnostico de determinadas causas de los derrames, como beta-2 transferrina, proteina-traza, creatinina, amilasa, bilirrubina, colesterol y trigliceridos o proteina C reactiva. Sin embargo, con frecuencia se solicitan al laboratorio numerosos parametros de dudosa utilidad. La relacion entre el medico asistencial y el laboratorio clinico es esencial para obtener la mayor rentabilidad diagnostica del analisis bioquimico en liquido pleural. Una adecuada seleccion de los parametros bioquimicos, a traves del conocimiento y de la informacion compartida, conlleva una mejor aproximacion diagnostica en el estudio del derrame pleural.
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- 2018
25. Analysis of microbiota in stable patients with chronic obstructive pulmonary disease
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Miguel Santibáñez, Alejandro Mira, Laura Sánchez-Guillén, Gloria Royo, Estefania Aguirre, Eduardo Garcia-Pachon, Antonio Galiana, Juan Carlos Rodríguez, and Ramón Guardiola
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DNA, Bacterial ,Male ,Microbiology (medical) ,Veillonella ,Polymerase Chain Reaction ,Pathology and Forensic Medicine ,Microbiology ,Pulmonary Disease, Chronic Obstructive ,RNA, Ribosomal, 16S ,Haemophilus ,Prevotella ,medicine ,Humans ,Immunology and Allergy ,Prospective Studies ,Moraxella ,Aged ,Aged, 80 and over ,Bacteria ,biology ,Microbiota ,Sputum ,General Medicine ,Middle Aged ,biology.organism_classification ,Bacterial Typing Techniques ,Molecular Typing ,RNA, Bacterial ,Fusobacterium ,Gemella ,Immunology ,Metagenome ,Female ,medicine.symptom ,Actinomyces - Abstract
To identify the bacterial diversity (microbiota) in expectorated sputum, a pyrosequencing method that investigates complex microbial communities of expectorated sputum was done in 19 stable chronic obstructive pulmonary disease patients (mean (SD) FEV1: 47 (18%) of predicted value). Using conventional culture, 3 phyla and 20 bacterial genera were identified, whereas the pyrosequencing approach detected 9 phyla and 43 genera (p < 0.001). In sputum the prevalent genera with pyrosequencing approach were Streptococcus, Actinomyces, Neisseria, Haemophilus, Rothia, Fusobacterium, Gemella, Granulicatella, Porphyromonas, Prevotella and Veillonella. Enterobacteriaceae, detected frequently in conventional culture, were not significantly detected with pyrosequencing methods. In addition, we found that important pathogens such as Haemophilus and Moraxella were detected more frequently with the new genetic procedures. The presence of Enterobacteriaceae is probably overestimated with conventional culture, whereas other difficult cultivable pathogens are underestimated. These studies open a new perspective for evaluating the role of bacterial colonization in chronic obstructive pulmonary disease pathogenesis and progression.
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- 2015
26. Transcriptomic Profiling of Pleural Effusions: Differences in Malignant and Infectious Fluids
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Lucía Zamora-Molina, Eduardo García-Pachón, Marta Amorós, Julia Gijón-Martínez, Judith Sánchez-Almendro, Carlos Baeza-Martínez, Luis Hernández-Blasco, and Antonio Galiana
- Subjects
biomarkers ,high-throughput sequencing ,inflammation ,mRNA ,pleural effusion ,transcriptome ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Different cellular and molecular processes are involved in the production of malignant and infectious pleural effusions. However, the underlying mechanisms responsible for these differences or their consequences remain incompletely understood. The objective of this study was to identify differences in gene expression in pleural exudates of malignant and infectious aetiology and establish the possible different biological processes involved in both situations. Materials and Methods: RNA transcriptomic analysis was performed on 46 pleural fluid samples obtained during diagnostic thoracocenteses from 46 patients. There were 35 exudates (19 malignant and 16 infectious effusions) and 11 transudates that were used as a reference control group. Differential gene expression analysis for both exudative groups was identified. An enrichment score using the Human Kegg Orthology database was used for establishing the biological processes associated with malignant and infectious pleural effusions. Results: When comparing malignant exudates with infectious effusions, 27 differentially expressed genes with statistical significance were identified. Network analysis showed ten different biological processes for malignant and for infectious pleural effusions. In malignant fluids, processes related to protein synthesis and processing predominate. In infectious exudates, biological processes in connection with ATP production prevail. Conclusions: This study demonstrates differentially expressed genes in malignant and infectious pleural effusions, which could have important implications in the search for diagnostic or prognostic biomarkers. In addition, for the first time, biological processes involved in these two causes of pleural exudates have been described.
- Published
- 2024
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27. Cistatina C en el derrame pleural
- Author
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Beatriz Quevedo-Sánchez, Marina Pellicer-Mas, Eduardo Garcia-Pachon, and Maria J. Soler-Sempere
- Subjects
Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,business - Published
- 2019
28. Cystatin C in Pleural Effusion
- Author
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Eduardo Garcia-Pachon, Maria J. Soler-Sempere, Beatriz Quevedo-Sánchez, and Marina Pellicer-Mas
- Subjects
Aged, 80 and over ,Male ,medicine.medical_specialty ,biology ,business.industry ,Pleural effusion ,MEDLINE ,Exudates and Transudates ,General Medicine ,Middle Aged ,medicine.disease ,Gastroenterology ,Pleural Effusion ,Cystatin C ,Internal medicine ,medicine ,biology.protein ,Humans ,Female ,Prospective Studies ,business ,Prospective cohort study ,Aged - Published
- 2019
29. Lactic Acidosis and Asthma Exacerbation
- Author
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María J. Martínez-Tébar, Eduardo Garcia-Pachon, and Alina C. Bodan
- Subjects
medicine.medical_specialty ,Asthma exacerbations ,business.industry ,Internal medicine ,Lactic acidosis ,medicine ,General Medicine ,medicine.disease ,business - Published
- 2019
30. Acidosis láctica y agudización del asma
- Author
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María J. Martínez-Tébar, Eduardo Garcia-Pachon, and Alina C. Bodan
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,business ,Gastroenterology - Published
- 2019
31. Sputum microbiota in moderate versus severe patients with COPD
- Author
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Miguel Santibáñez, Pedro Garcinuño, Eduardo Garcia-Pachon, Francisco José Ruiz López, Estefania Aguirre, Inmaculada Candela, Juan Carlos Rodríguez, M. Ruiz, Juana Llavero, Alex Mira, Antonio Galiana, and Gloria Royo
- Subjects
Pulmonary and Respiratory Medicine ,COPD ,Exacerbation ,business.industry ,Amplicon ,medicine.disease ,16S ribosomal RNA ,Bioinformatics ,DNA extraction ,Obstructive lung disease ,Real-time polymerase chain reaction ,Immunology ,medicine ,Sputum ,medicine.symptom ,business - Abstract
To the Editor: The emergence of new massive sequencing methods has proved revolutionary for the study of complex microbial populations such as the microbiota of the respiratory tract in patients with chronic obstructive pulmonary disease (COPD) [1]. Using this powerful methodology, our objective was to compare the microbiota in two groups of patients with COPD of different severity in order to detect potential microbiological markers that could help to provide a better understanding of the pathogenesis of this disease and the role played by the microbiota in its severity. The current study recruited nine patients with mild or moderate COPD and 10 patients with severe or very severe COPD in a stable condition (at least 3 months without exacerbation or use of antibiotics for any other reason). Diagnosis and classification of COPD was established according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations [2]. After DNA extraction from good quality expectorated sputum, quantitative (q)PCR (7500 real time PCR system thermocycler; Life Technologies, Grand Island, NY, USA) was used to quantify the copy number of the 16S rRNA gene in each sample (total bacterial load), yielding a 468 bp amplicon located between nucleotides 340–808 in reference to the 16S rRNA gene of Escherichia coli strain MG1655 (National Center for Biotechnology Information (NCBI) reference sequence: NR_102804.1). In order to compare the results obtained, they were normalised to the number of human cells in the sample, quantified by qPCR, using the human albumin gene [3]. A region measuring 525 bp, between position 8 and 533 of the 16S rRNA gene was amplified and pyrosequenced (Roche GS FLX Titanium with Lib-L type microspheres; 454 Life Sciences, Branford, CT, USA). This region comprises the regions of gene hypervariability from V1 to V3 of the 16S rRNA gene …
- Published
- 2013
32. Malignant pleural effusion: first steps towards therapy
- Author
-
Eduardo Garcia-Pachon
- Subjects
education.field_of_study ,medicine.medical_specialty ,business.industry ,Population ,Medicine ,Cancer ,Malignant pleural effusion ,Radiology ,business ,medicine.disease ,education ,Poor quality ,Malignant disease - Abstract
MPE consists in the accumulation of fluid in the pleural space due to a malignant disease. MPE is a difficult to treat clinical condition which frequently results in severe symptoms like dyspnoea (that can be invalidating) or pain, and poor quality of live. The majority of MPE is caused by metastases from distant cancers, most commonly from the lungs and breast (1), but it is possible to occur in almost all types of cancer, and up to 15% of all patients with any malignant disease have an MPE (2). This condition affects 500–700 individuals per million population annually (3).
- Published
- 2018
33. Flexible bronchoscopy in very old patients with lung cancer
- Author
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Lucía Zamora-Molina, Eduardo Garcia-Pachon, Carlos Baeza-Martinez, Justo Grau-Delgado, and Maria J. Soler-Sempere
- Subjects
Old patients ,medicine.medical_specialty ,Geriatrics gerontology ,business.industry ,General surgery ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,030212 general & internal medicine ,Lung cancer ,business ,Flexible bronchoscopy - Published
- 2018
34. Comparison of methods of DNA extraction for real-time PCR in a model of pleural tuberculosis
- Author
-
Gloria Royo, Rosa Cremades, Ana Santos, Eduardo Garcia-Pachon, Juan Carlos Rodríguez, and M. Ruiz
- Subjects
Microbiology (medical) ,Pathology ,medicine.medical_specialty ,Chromatography ,Tuberculosis ,biology ,business.industry ,Pleural effusion ,General Medicine ,biology.organism_classification ,medicine.disease ,DNA extraction ,Pathology and Forensic Medicine ,law.invention ,Mycobacterium tuberculosis ,Pleural disease ,Real-time polymerase chain reaction ,Pleurisy ,law ,medicine ,Immunology and Allergy ,business ,Polymerase chain reaction - Abstract
Molecular methods have been reported to have different sensitivities in the diagnosis of pleural tuberculosis and this may in part be caused by the use of different methods of DNA extraction. Our study compares nine DNA extraction systems in an experimental model of pleural tuberculosis. An inoculum of Mycobacterium tuberculosis was added to 23 pleural liquid samples with different characteristics. DNA was subsequently extracted using nine different methods (seven manual and two automatic) for analysis with real-time PCR. Only two methods were able to detect the presence of M. tuberculosis DNA in all the samples: extraction using columns (Qiagen) and automated extraction with the TNAI system (Roche). The automatic method is more expensive, but requires less time. Almost all the false negatives were because of the difficulty involved in extracting M. tuberculosis DNA, as in general, all the methods studied are capable of eliminating inhibitory substances that block the amplification reaction. The method of M. tuberculosis DNA extraction used affects the results of the diagnosis of pleural tuberculosis by molecular methods. DNA extraction systems that have been shown to be effective in pleural liquid should be used.
- Published
- 2010
35. Broncofibroscopia en pacientes mayores de 80 años
- Author
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Antonio Noguera-Sánchez, Lucía Zamora-Molina, Justo Grau-Delgado, Maria J. Soler-Sempere, Eduardo Garcia-Pachon, and Isabel Padilla-Navas
- Subjects
Aging ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General surgery ,Medicine (miscellaneous) ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Bronchoscopy ,medicine ,030212 general & internal medicine ,Bronchoscopes ,Geriatrics and Gerontology ,business - Published
- 2017
36. Producción española sobre tuberculosis a través del MEDLINE (1997–2006)
- Author
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Mar Masiá, Félix Gutiérrez, Eduardo Garcia-Pachon, Sergio Padilla, and José Ramos
- Subjects
Pulmonary and Respiratory Medicine ,business.industry ,Medicine ,business ,Humanities - Abstract
Resumen Introduccion El objetivo del estudio ha sido analizar la produccion cientifica espanola sobre tuberculosis durante una decada (1997–2006) y contextualizarla en el marco de la Union Europea (UE). Material y metodos Se ha realizado un estudio bibliometrico a traves de la base de datos MEDLINE via PubMed, mediante la busqueda de “ tuberculosis ” o “ tuberculous ” en cualquier campo de la base de datos. Resultados Se recopilaron 35.735 documentos que trataban sobre tuberculosis, de los cuales 1.191 (el 4,1% de la produccion mundial) fueron publicados por autores espanoles. Espana fue el tercer pais con mas documentos de la UE, con el 13,5%. El 51,2% (n=610) se publicaron en ingles y el 48,8% (n=581) en espanol. El numero de documentos fue constante a lo largo de los anos. La especialidad del primer firmante mas frecuente fue microbiologia, con 225 documentos (20,6%), seguida de medicina interna (n=154; 14,1%) y neumologia (n=117; 10,7%). Las revistas con un mayor numero de documentos publicados fueron Medicina Clinica y Enfermedades Infecciosas y Microbiologia Clinica , con 78 (6,5%) cada una, Anales de Medicina Interna (n=72), Revista Clinica Espanola (n=64) y Archivos de Bronconeumologia (n=63). Las provincias mas productoras fueron Madrid y Barcelona, con 272 (22,8%) y 256 (21,5%) documentos publicados, respectivamente. Las instituciones mas productivas fueron los hospitales, con 900 documentos (75,6%), seguidos de las universidades, con 132 (11,1%). Conclusiones La investigacion sobre tuberculosis en Espana ha sido constante a lo largo de los ultimos 10 anos y ha supuesto una aportacion importante en el conjunto de la UE. La mitad de las publicaciones espanolas se hicieron en revistas extranjeras y procedian predominantemente de los hospitales.
- Published
- 2009
37. In VitroBactericidal Activity of Antibiotic Combinations Against Clinical Isolates ofMycobacterium chelonae
- Author
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Rosa Cremades, M. Ruiz, Juan Carlos Rodríguez, Gloria Royo, André L. Santos, and Eduardo Garcia-Pachon
- Subjects
medicine.drug_class ,Antibiotics ,Mycobacterium Infections, Nontuberculous ,Mycobacterium chelonae ,Microbial Sensitivity Tests ,In Vitro Techniques ,Pharmacology ,Microbiology ,chemistry.chemical_compound ,Moxifloxacin ,Clarithromycin ,Drug Resistance, Multiple, Bacterial ,polycyclic compounds ,medicine ,Tobramycin ,Humans ,Pharmacology (medical) ,Antibacterial agent ,biology ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,Anti-Bacterial Agents ,Infectious Diseases ,Oncology ,chemistry ,Linezolid ,Drug Therapy, Combination ,Gentamicin ,medicine.drug - Abstract
Mycobacterium chelonae is one of the most antibiotic-resistant species of the pathogenic, rapidly-growing mycobacteria. The objective of this study was to evaluate the bactericidal activity of classical and new potential drugs, alone and in combinations, against clinical isolates of Mycobacterium chelonae. Clarithromycin was seen to be the most bactericidal drug. In drug combinations, this compound is most useful with gentamicin, fluoroquinolones, rifampicin, linezolid, other aminoglycosides, doxycyline and carbapenems. The combination of tobramycin with ciprofloxacin or moxifloxacin also exhibits similar activity. In conclusion, this study on bactericidal activity of drug combinations against Mycobacterium chelonae confirms the utility of clarithromycin associated with other drugs, and, of the new drugs, the value of moxifloxacin and linezolid.
- Published
- 2008
38. Red cell macrocytosis in COPD patients without respiratory insufficiency: A brief report
- Author
-
Eduardo Garcia-Pachon and Isabel Padilla-Navas
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Red cell ,Erythrocytes, Abnormal ,Macrocytosis ,Pulmonary Disease, Chronic Obstructive ,Forced Expiratory Volume ,Internal medicine ,medicine ,COPD ,Humans ,Respiratory system ,Mean corpuscular volume ,Aged ,Erythrocyte Volume ,medicine.diagnostic_test ,Red Cell ,business.industry ,Smoking ,Respiratory disease ,medicine.disease ,respiratory tract diseases ,Surgery ,Oxygen ,Dyspnea ,medicine.anatomical_structure ,Female ,business ,circulatory and respiratory physiology ,Respiratory tract - Abstract
SummaryRed cell macrocytosis has been frequently described in hypoxemic patients with chronic obstructive pulmonary disease (COPD). However, macrocytosis is not related to hyoxemia. The objective of this study was to determine the frequency of macrocytosis (defined as mean corpuscular volume (MCV) higher than 94fl) in stable COPD patients without respiratory insufficiency, and to analyze the possible relationship between its presence and clinical and functional parameters. Fifty-eight consecutive patients with COPD, and without other significant comorbid conditions, were included in the study. Macrocytosis was present in 17 of the 58 stable COPD patients (29%). The differences between patients with and without macrocytosis were not statistically significant, except for MCV. In the subgroup of 36 ex-smoker COPD patients, macrocytosis was present in nine patients (25%). In this subgroup, MCV significantly correlated with dyspnea (r=0.36, P=0.03) and forced expiratory volume in 1s (FEV1) (r=−0.35, P=0.03). We conclude that macrocytosis is a frequent finding in stable non-hypoxemic COPD patients, and that in ex-smoker patients the degree of macrocytosis is associated with a worse clinical situation in terms of dyspnea and FEV1.
- Published
- 2007
39. Importance of the Efflux Pump Systems in the Resistance of Mycobacterium tuberculosis to Fluoroquinolones and Linezolid
- Author
-
Eduardo Garcia-Pachon, B Llorca, Juan Carlos Rodríguez, Gloria Royo, Isabel Escribano, and M. Ruiz
- Subjects
Pharmacology ,biology ,Chemistry ,medicine.drug_class ,Antibiotics ,General Medicine ,Drug resistance ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,Mycobacterium tuberculosis ,Minimum inhibitory concentration ,chemistry.chemical_compound ,Infectious Diseases ,Oncology ,Levofloxacin ,Drug Discovery ,Linezolid ,medicine ,heterocyclic compounds ,Pharmacology (medical) ,Efflux ,Ofloxacin ,medicine.drug - Abstract
Objective: Our aim was to study the influence of efflux pump systems in the resistance of Mycobacterium tuberculosis to fluoroquinolones and linezolid. Methods: We studied the mutations in gyrA and gyrB genes and the influence of efflux pump systems with 2 inhibitors (reserpine and MC 207.110). Results: The effect of the active efflux system on the decrease in sensitivity to ciprofloxacin, moxifloxacin, levofloxacin, ofloxacin, gatifloxacin and linezolid was studied by investigating the variation in the in vitro activity of these compounds when assayed in association with reserpine and MC 207.110. These inhibitors exhibit activity both in strains that are resistant and in strains that are susceptible to these antibiotics. However, they are seen to be most active in resistant strains, since the minimum inhibitory concentration of the antibiotics studied in these strains was reduced between 2- and 6-fold. Conclusions: Therefore, these mechanisms are involved in the resistance to both compounds. It would be of interest to carry out further studies to determine to what extent these active efflux systems influence resistance to the different groups of drugs used in the treatment of tuberculosis, with a view to the possibility of using the inhibitors of these systems in future therapeutic applications.
- Published
- 2007
40. Urinothorax: a new approach
- Author
-
Santiago Romero and Eduardo Garcia-Pachon
- Subjects
Pulmonary and Respiratory Medicine ,Urinothorax ,medicine.medical_specialty ,Proteinuria ,L-Lactate Dehydrogenase ,Pleural effusion ,business.industry ,Urinary system ,Hydrogen-Ion Concentration ,Pleural Diseases ,Creatine ,medicine.disease ,Transudate ,Pleural Effusion ,Etiology ,medicine ,Humans ,In patient ,Radiology ,medicine.symptom ,business ,Obstructive uropathy - Abstract
Purpose of review The presence of urine in the pleural space (urinothorax) is a rarely recognized cause of pleural effusion. To date, only 58 cases have been reported. In this article the features of urinothorax are analyzed, and clinical and biochemical characteristics are reviewed in order to propose a classification, founded on pathogenic criteria, that will be useful in achieving the diagnosis. Recent findings Recently reported cases of urinothorax provide a more detailed description of the biochemical characteristics that allow a better understanding of this entity. Summary Urinothorax can be divided into two categories: (1) obstructive urinothorax, due to bilateral obstructive uropathy; and (2) traumatic urinothorax, due to unilateral traumatic injury of the urinary system, mostly iatrogenic. In patients with urinothorax, the pleural effusion usually has the biochemical characteristics of a transudate, with a pH lower than 7.30 and a pleural fluid/serum creatinine ratio higher than 1. These characteristics are not always present, however, and individually are shared by a significant number of pleural effusions of different etiology.
- Published
- 2006
41. Frequency of Hoover's sign in stable patients with chronic obstructive pulmonary disease
- Author
-
Isabel Padilla-Navas and Eduardo Garcia-Pachon
- Subjects
Spirometry ,COPD ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Respiratory disease ,Pulmonary disease ,Hoover's sign ,Physical examination ,General Medicine ,medicine.disease ,respiratory tract diseases ,Surgery ,Internal medicine ,medicine ,medicine.symptom ,business ,Body mass index ,Sign (mathematics) - Abstract
Hoover's sign (the inward motion of the lower lateral rib cage with inspiration) is conventionally considered to be a sign of severe disease in chronic obstructive pulmonary disease (COPD). However, no studies have been done regarding the frequency of Hoover's sign in patients with stable COPD. We aim to establish the frequency of Hoover's sign in a large series of stable patients with COPD and to analyse the characteristics associated with its presence. One hundred and fifty-seven consecutive patients with COPD, 150 of whom were men (95%), with a mean (standard deviation) age of 68 (8) years were included. Seventy-one patients had Hoover's sign (45%) on clinical examination. Hoover's sign was not detected in mild COPD patients, and it was present in 36% of moderate, 43% of severe and 76% of very severe COPD patients. In the multivariate analysis, dyspnea, body mass index (BMI), number of exacerbations and number of prescribed drugs were independently associated with the presence of Hoover's sign in COPD. Hoover's sign is a frequent finding in COPD, and the frequency increases with severity. Its presence is independently related to higher values of dyspnea, BMI, number of exacerbations and number of prescribed drugs.
- Published
- 2006
42. Epidemiología molecular de la tuberculosis: principales hallazgos y su aplicación en España
- Author
-
Eduardo Garcia-Pachon and Juan Carlos Rodríguez
- Subjects
Pulmonary and Respiratory Medicine ,business.industry ,Medicine ,business ,Humanities - Published
- 2005
43. C-Reactive Protein in Lymphocytic Pleural Effusions: A Diagnostic Aid in Tuberculous Pleuritis
- Author
-
Maria J. Soler, Isabel Padilla-Navas, Victor Romero, Eduardo Garcia-Pachon, and Conrado Shum
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Tuberculosis ,Pleural effusion ,Diagnostic aid ,Pleural disease ,Predictive Value of Tests ,Humans ,Medicine ,Lymphocyte Count ,Aged ,Aged, 80 and over ,biology ,business.industry ,C-reactive protein ,Respiratory disease ,Exudates and Transudates ,Tuberculosis, Pleural ,Middle Aged ,respiratory system ,medicine.disease ,humanities ,respiratory tract diseases ,Pleural Effusion ,C-Reactive Protein ,Pleurisy ,Case-Control Studies ,biology.protein ,Pleural fluid ,Female ,business - Abstract
Background:C-reactive protein (CRP) pleural fluid levels have been found to be higher in tuberculosis and parapneumonic effusions than in other causes of pleural effusion. Objective:The aim of this study was to analyze whether CRP (a simple and inexpensive test) may be a diagnostic aid for tuberculosis in lymphocytic pleural effusions. Methods:One hundred and forty-four patients with a lymphocytic pleural effusion (more than 50% lymphocytes in the differential white blood cell count) were included. The patients were 93 men (65%) and 51 women (35%), aged 64 ± 18 years (mean ± SD). The diagnoses were as follows: tuberculosis, 20; pleural effusion associated with malignancy, 69; transudates, 38; other benign exudates, 17. Results: The CRP pleural fluid level was higher in tuberculous pleuritis (54 ± 24 mg/l) than in lymphocytic effusions of other origin (21 ± 16 mg/l; p < 0.001). High CRP levels (≧50 mg/l) have a high specificity for tuberculosis (95%), and low levels (Conclusions: CRP pleural fluid level determination is useful in the diagnostic workup of lymphocytic pleural effusions. High CRP levels are very suggestive of tuberculous pleuritis, and low CRP levels make this diagnosis unlikely.
- Published
- 2005
44. Can pulse oximetry select patients for screening spirometry?
- Author
-
Eduardo Garcia-Pachon
- Subjects
Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,COPD ,medicine.diagnostic_test ,Pulse (signal processing) ,business.industry ,fungi ,Public Health, Environmental and Occupational Health ,Primary care ,medicine.disease ,respiratory tract diseases ,Pulse oximetry ,FEV1/FVC ratio ,Emergency medicine ,Physical therapy ,medicine ,business ,Original Research - Abstract
AIM: To investigate whether the measurement of arterial oxygen saturation (SpO(2)) with pulse oximetry can identify those patients for whom spirometric screening for COPD would be useful, and those patients for whom spirometric assessment would not be useful. METHODS: Two hundred and ten patients, aged over 40, without significant dyspnoea, referred by their primary care physicians to the outpatient pulmonary clinic. The value of SpO(2) was recorded with a finger clip pulse oximeter sensor. Diagnostic values were obtained in order to diagnose COPD (defined as an FEV(1)/FVC ratio
- Published
- 2004
45. Gender inequality in the authorship of medical articles: Analysis of Medicina Clínica, 1999 and 2014
- Author
-
Lucía Zamora Molina, María José Soler Sempere, Eduardo Garcia-Pachon, and Isabel Padilla-Navas
- Subjects
Gender inequality ,business.industry ,Medicine ,Gender studies ,business - Published
- 2015
46. Desigualdad de género en la autoría de artículos médicos: análisis de Medicina Clínica en 1999 y 2014
- Author
-
Eduardo Garcia-Pachon, Isabel Padilla-Navas, María José Soler Sempere, and Lucía Zamora Molina
- Subjects
business.industry ,Medicine ,General Medicine ,business ,Humanities - Published
- 2015
47. Paradoxical Movement of the Lateral Rib Margin (Hoover Sign) for Detecting Obstructive Airway Disease
- Author
-
Eduardo Garcia-Pachon
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Chronic bronchitis ,medicine.drug_class ,Ribs ,Physical examination ,Critical Care and Intensive Care Medicine ,Sensitivity and Specificity ,Likelihood ratios in diagnostic testing ,Rhonchi ,FEV1/FVC ratio ,Predictive Value of Tests ,Bronchodilator ,Internal medicine ,medicine ,Humans ,Lung Diseases, Obstructive ,Aged ,Respiratory Sounds ,Observer Variation ,COPD ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Surgery ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Study objective To evaluate the diagnostic accuracy of Hoover sign for detecting obstructive airway disease (OAD), compared with wheezes, rhonchi, reduced breath sounds, and clinical impression, and to analyze the observer agreement on these signs. Design Prospective, blind comparison, with a reference standard (spirometry) among a consecutive series of patients. Setting Outpatient pulmonary clinic. Patients One hundred seventy-two patients (117 men [68%] and 55 women [32%]), who were > 40 years of age, had not been known previously by the participating physicians, and met at least one of the following criteria: smokers of > 20 pack-years; patients who had received a diagnosis of or had self-reported COPD (or chronic bronchitis or emphysema); patients who had received inhaler bronchodilator treatment for > 6 months; or patients with any degree of dyspnea. Measurements Patients were examined by a first-year resident in family medicine and by a pulmonologist. Spirometry was performed by a blinded trained technician. OAD was defined as an FEV 1 /FVC ratio of Results OAD was present in 64 patients (37%). Observer agreement (κ statistic) was 0.74 for Hoover sign and was lower for the rest of the signs. Hoover sign had a sensitivity of 58% and a specificity of 86% for detecting OAD, and it had a positive likelihood ratio of 4.16, which was higher than that of the other signs. Conclusions Hoover sign, a frequently forgotten sign, is easy to recognize and is useful for detecting OAD.
- Published
- 2002
48. Diagnostic value of C-reactive protein in exudative pleural effusions
- Author
-
I Llorca and Eduardo Garcia-Pachon
- Subjects
Pathology ,medicine.medical_specialty ,biology ,business.industry ,C-reactive protein ,Diagnostic accuracy ,Malignancy ,medicine.disease ,Exudative pleural effusion ,Positive predicative value ,Internal Medicine ,medicine ,biology.protein ,Pleural fluid ,Malignant pleural effusion ,business - Abstract
BACKGROUND: Tests able to help in the diagnostic work-up of pleural exudates are needed. C-reactive protein (CRP) may be useful for distinguishing between benign and malignant exudates. METHODS: A total of 123 consecutive patients diagnosed as having exudative pleural effusion (60 associated with malignancy and 63 benign effusions) were included in the study. Sensitivity, specificity, positive and negative predictive values (PV+, PV-), and positive and negative likelihood ratios (LR+, LR-) were established at different cut-off points. RESULTS: Pleural fluid CRP level was 23+/-12 mg/l (mean+/-S.D.) in pleural exudates associated with malignancy and 50+/-33 mg/l in benign effusions (P0.001). With a cut-off point below 20 mg/l for malignancy, sensitivity of CRP was 0.50, specificity 0.89, PV+ 0.81, PV- 0.65, LR+ 4.50, and LR- 0.65. With a cut-off point above 45 mg/l for benign diseases, sensitivity was 0.44, specificity 0.95, PV+ 0.90, PV- 0.62, LR+ 8.89, and LR- 0.58. CONCLUSIONS: The pleural CRP level provides useful information for the study of pleural exudates. A level below 20 mg/l suggests a malignant origin and a level above 45 mg/l virtually rules out this possibility. Additional advantages of measuring CRP level are that it is an inexpensive test and is easy to perform.
- Published
- 2002
49. Comparison of the bactericidal activity of various fluoroquinolones against Mycobacterium tuberculosis in an in vitro experimental model
- Author
-
Pilar López, Montserrat Ruiz-García, Rosa Cremades, Antonio Galiana, Eduardo Garcia-Pachon, Gloria Royo, and Juan Carlos Rodríguez
- Subjects
Microbiology (medical) ,Ofloxacin ,Tuberculosis ,medicine.drug_class ,Moxifloxacin ,Antibiotics ,Antitubercular Agents ,Levofloxacin ,Microbial Sensitivity Tests ,Microbiology ,Mycobacterium tuberculosis ,Ciprofloxacin ,Drug Resistance, Bacterial ,Isoniazid ,medicine ,Humans ,heterocyclic compounds ,Pharmacology (medical) ,Pharmacology ,Aza Compounds ,biology ,Latent tuberculosis ,business.industry ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,Infectious Diseases ,Spain ,Quinolines ,business ,Fluoroquinolones ,medicine.drug - Abstract
To compare the bactericidal activity of various fluoroquinolones against Mycobacterium tuberculosis in the latent and exponential growth phases.Ciprofloxacin, levofloxacin and moxifloxacin were tested against 16 M. tuberculosis clinical isolates (4 resistant and 12 susceptible to fluoroquinolones) from Elche, Spain, isolated between 1992 and 2009. To study bactericidal activity, an inoculum of approximately 10(5) cfu of each isolate was cultured in Middlebrook 7H9 broth. The broth was previously acidified to pH 4.6 to obtain the microorganism in the stationary phase. Cultures with different concentrations (0.1 to 50 mg/L) of antibiotic and antibiotic-free controls were incubated for 48 h then plated onto Middlebrook 7H11 to detect bacterial killing. In all stages of the process the M. tuberculosis strain ATCC 41323 was included as a quality control to ensure reproducible results.Moxifloxacin and levofloxacin were found to exhibit bactericidal activity at lower concentrations and against more strains in both the latent and the exponential growth phases compared with ciprofloxacin. The bactericidal activity of moxifloxacin was greater than that of levofloxacin against microorganisms in the exponential growth phase, but the opposite was true in the latent phase.Our data confirm the usefulness of moxifloxacin in the treatment of tuberculosis and suggest that levofloxacin may be used as an alternative drug in the treatment of latent tuberculosis when it is not possible to use isoniazid. Based on the results presented, ciprofloxacin appears to be a poor choice.
- Published
- 2011
50. Should self-citation of articles be penalized?
- Author
-
Eduardo Garcia-Pachon and Isabel Padilla-Navas
- Subjects
Self citation ,Publishing ,Medical education ,business.industry ,MEDLINE ,Medicine ,General Medicine ,Journal Impact Factor ,business ,Authorship - Published
- 2014
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