Back to Search
Start Over
In VitroBactericidal Activity of Antibiotic Combinations Against Clinical Isolates ofMycobacterium chelonae
- Source :
- Journal of Chemotherapy. 20:43-47
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- Mycobacterium chelonae is one of the most antibiotic-resistant species of the pathogenic, rapidly-growing mycobacteria. The objective of this study was to evaluate the bactericidal activity of classical and new potential drugs, alone and in combinations, against clinical isolates of Mycobacterium chelonae. Clarithromycin was seen to be the most bactericidal drug. In drug combinations, this compound is most useful with gentamicin, fluoroquinolones, rifampicin, linezolid, other aminoglycosides, doxycyline and carbapenems. The combination of tobramycin with ciprofloxacin or moxifloxacin also exhibits similar activity. In conclusion, this study on bactericidal activity of drug combinations against Mycobacterium chelonae confirms the utility of clarithromycin associated with other drugs, and, of the new drugs, the value of moxifloxacin and linezolid.
- Subjects :
- medicine.drug_class
Antibiotics
Mycobacterium Infections, Nontuberculous
Mycobacterium chelonae
Microbial Sensitivity Tests
In Vitro Techniques
Pharmacology
Microbiology
chemistry.chemical_compound
Moxifloxacin
Clarithromycin
Drug Resistance, Multiple, Bacterial
polycyclic compounds
medicine
Tobramycin
Humans
Pharmacology (medical)
Antibacterial agent
biology
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
biology.organism_classification
Anti-Bacterial Agents
Infectious Diseases
Oncology
chemistry
Linezolid
Drug Therapy, Combination
Gentamicin
medicine.drug
Subjects
Details
- ISSN :
- 19739478 and 1120009X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Chemotherapy
- Accession number :
- edsair.doi.dedup.....c6702c3dc1ef81ac28c5feab978892bf