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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.addbeh.2009.03.029 Byline: Li-Tzy Wu (a), Andy C. Parrott (b), Christopher L. Ringwalt (c), Ashwin A. Patkar (a), Paolo Mannelli (a), Dan G. Blazer (a) Keywords: Alcohol use disorder; Ecstasy; Marijuana use disorder; MDMA; Substance use disorder Abstract: In light of the resurgence in MDMA use and its association with polysubstance use, we investigated the 12-month prevalence of substance use disorders (SUDs) among adult MDMA users to determine whether they are at risk of other drug-related problems that would call for targeted interventions. Author Affiliation: (a) Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Box 3419, Durham, NC 27710, USA (b) Department of Psychology, Swansea University, Swansea SA2 8PP, UK (c) Pacific Institute for Research and Evaluation, Chapel Hill Center, 1516 E. Franklin St., Suite 200, Chapel Hill, NC 27514-2812, USA

The study analyzed the relationship between severity of consumption of different drugs and neuropsychological performance on tasks sensitive to impairment in the executive subprocesses, which include working memory. Results showed a differential impact of severity of methylenedioxymethamphetamine (MDMA) abuse on working memory and abstract reasoning indices, and of cocaine severity on an inhibitory control index.