Differential effects of MDMA, cocaine, and cannabis use severity on distinctive components of the executive functions in polysubstance users: A multiple regression analysis

The study analyzed the relationship between severity of consumption of different drugs and neuropsychological performance on tasks sensitive to impairment in the executive subprocesses, which include working memory. Results showed a differential impact of severity of methylenedioxymethamphetamine (MDMA) abuse on working memory and abstract reasoning indices, and of cocaine severity on an inhibitory control index.