1. Carbazole scaffolds in cancer therapy: a review from 2012 to 2018
- Author
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Saïd Yous, Pal Rongved, Samar Issa, Marc Le Borgne, Nicolas Bedel, Zouhair Bouaziz, Anthony Prandina, Ecole de Biologie Industrielle (EBI), Molécules bioactives et chimie médicinale (B2MC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, University of Oslo (UiO), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, and Le Borgne, Marc
- Subjects
[SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication ,[CHIM.THER] Chemical Sciences/Medicinal Chemistry ,enzyme inhibitors ,Cancer therapy ,Carbazole ,Carbazoles ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Antineoplastic Agents ,[CHIM.THER]Chemical Sciences/Medicinal Chemistry ,Review Article ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication ,Neoplasms ,Drug Discovery ,cancer ,Animals ,Humans ,Structural motif ,Cell Proliferation ,Pharmacology ,Molecular Structure ,010405 organic chemistry ,lcsh:RM1-950 ,General Medicine ,HEXA ,targeted therapy ,Combinatorial chemistry ,3. Good health ,0104 chemical sciences ,lcsh:Therapeutics. Pharmacology ,chemistry ,[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,cytotoxicity - Abstract
International audience; For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products. Carbazoles have taken an important part in all the existing anti-cancer drugs because of their discovery from a large variety of organisms, including bacteria, fungi, plants, and animals. In this article, we specifically explored the literature from 2012 to 2018 on the anti-tumour activities reported to carbazole derivatives and we have critically collected the most significant data. The most described carbazole anti-tumour agents were classified according to their structure, starting from the tricyclic-carbazole motif to fused tetra-, penta-, hexa-and heptacyclic carba-zoles. To date, three derivatives are available on the market and approved in cancer therapy.
- Published
- 2019