50 results on '"Durmo, R"'
Search Results
2. OP0269 TREATMENT OF GIANT CELL ARTERITIS WITH ULTRA-SHORT GLUCOCORTICOIDS AND TOCILIZUMAB: RESULTS FROM THE EXTENSION TO 76 WEEKS
- Author
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Marvisi, C., primary, Muratore, F., additional, Ricordi, C., additional, Boiardi, L., additional, Besutti, G., additional, Spaggiari, L., additional, Durmo, R., additional, Croci, S., additional, Versari, A., additional, Giorgi Rossi, P., additional, and Salvarani, C., additional
- Published
- 2024
- Full Text
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3. OP0233 CAN TOCILIZUMAB TURN OFF INFLAMMATION IN GIANT CELL ARTERITIS?
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Ricordi, C., primary, Marvisi, C., additional, Macchioni, P., additional, Boiardi, L., additional, Cavazza, A., additional, Croci, S., additional, Bonacini, M., additional, Malchiodi, G., additional, Durmo, R., additional, Versari, A., additional, Muratore, F., additional, and Salvarani, C., additional
- Published
- 2024
- Full Text
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4. End of induction [18F]FDG PET is prognostic for progression-free survival and overall survival in follicular lymphoma patients enrolled in the FOLL12 trial
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Guerra, L, Chauvie, S, Fallanca, F, Bergesio, F, Marcheselli, L, Durmo, R, Peano, S, Franceschetto, A, Monaco, L, Barbieri, E, Ladetto, M, Musuraca, G, Tosi, P, Bianchi, B, Bolis, S, Pavone, V, Chiarenza, A, Arcari, A, Califano, C, Bari, A, Massaia, M, Conconi, A, Musto, P, Mannina, D, Roti, G, Galimberti, S, Gini, G, Falcinelli, F, Vitolo, U, Usai, S, Stefani, P, Ibatici, A, Liberati, A, Pennese, E, Perrone, T, Versari, A, Luminari, S, Guerra, Luca, Chauvie, Stephane, Fallanca, Federico, Bergesio, Fabrizio, Marcheselli, Luigi, Durmo, Rexhep, Peano, Simona, Franceschetto, Antonella, Monaco, Lavinia, Barbieri, Emiliano, Ladetto, Marco, Musuraca, Gerardo, Tosi, Patrizia, Bianchi, Benedetta, Bolis, Silvia Anna Maria, Pavone, Vincenzo, Chiarenza, Annalisa, Arcari, Annalisa, Califano, Catello, Bari, Alessia, Massaia, Massimo, Conconi, Annarita, Musto, Pellegrino, Mannina, Donato, Roti, Giovanni, Galimberti, Sara, Gini, Guido, Falcinelli, Flavio, Vitolo, Umberto, Usai, Sara Veronica, Stefani, Piero Maria, Ibatici, Adalberto, Liberati, Anna Marina, Pennese, Elsa, Perrone, Tommasina, Versari, Annibale, Luminari, Stefano, Guerra, L, Chauvie, S, Fallanca, F, Bergesio, F, Marcheselli, L, Durmo, R, Peano, S, Franceschetto, A, Monaco, L, Barbieri, E, Ladetto, M, Musuraca, G, Tosi, P, Bianchi, B, Bolis, S, Pavone, V, Chiarenza, A, Arcari, A, Califano, C, Bari, A, Massaia, M, Conconi, A, Musto, P, Mannina, D, Roti, G, Galimberti, S, Gini, G, Falcinelli, F, Vitolo, U, Usai, S, Stefani, P, Ibatici, A, Liberati, A, Pennese, E, Perrone, T, Versari, A, Luminari, S, Guerra, Luca, Chauvie, Stephane, Fallanca, Federico, Bergesio, Fabrizio, Marcheselli, Luigi, Durmo, Rexhep, Peano, Simona, Franceschetto, Antonella, Monaco, Lavinia, Barbieri, Emiliano, Ladetto, Marco, Musuraca, Gerardo, Tosi, Patrizia, Bianchi, Benedetta, Bolis, Silvia Anna Maria, Pavone, Vincenzo, Chiarenza, Annalisa, Arcari, Annalisa, Califano, Catello, Bari, Alessia, Massaia, Massimo, Conconi, Annarita, Musto, Pellegrino, Mannina, Donato, Roti, Giovanni, Galimberti, Sara, Gini, Guido, Falcinelli, Flavio, Vitolo, Umberto, Usai, Sara Veronica, Stefani, Piero Maria, Ibatici, Adalberto, Liberati, Anna Marina, Pennese, Elsa, Perrone, Tommasina, Versari, Annibale, and Luminari, Stefano
- Abstract
Purpose: To evaluate the reliability of the Deauville score (DS) in therapy response assessment and to define the prognostic value of the metabolic response of end of induction (EOI) [18F]FDG PET (PET) in follicular lymphoma patients. Methods: Adult patients with untreated grade 1-3a FL/ stage II-IV enrolled in the multicentre, prospective, phase III FOLL12 trial (NCT02063685) were randomized to receive standard immunochemotherapy followed by rituximab maintenance (standard arm) versus standard immunochemotherapy followed by response-adapted post-induction management (experimental arm). Baseline and EOI PET were mandatory for the study. All PET scans were centralized on the WIDEN® platform and classified according to DS in a blind independent central review. DS1-3 was considered negative (CMR), whereas DS4-5 was considered positive (not CMR). The primary endpoint was PFS. The main secondary endpoint was overall survival (OS). Results: Overall, 807 follicular lymphoma patients-52% women, 89% stage III-IV disease, 40% with a high-risk FLIPI-2 score (3-5)-were enrolled in the study; 729 (90.4%) baseline and EOI PET were available for the analysis. EOI PET was positive (DS4-5) in 88/729 (12.1%) cases. Overall inter-reviewer agreement on PET pos/neg result was 0.92, while agreement on positive and negative cases was 0.77 and 0.94, respectively. The median follow-up was 69 months; 247 events were registered in the 5-yr follow-up, with a 5-yr PFS of 67% (95%CI: 63%-70%). The 5-yr PFS rate for PET neg (DS1-3) and PET pos (DS4-5) patients was 71% (95%CI: 67%-75%) and 36% (95%CI: 25%-46%), respectively, with HR 3.49 (95%CI: 2.57-4.72). Five-year PFS was worse as DS increased, with 74% (70%-78%), 58% (48%-67%; HR 1.71; p = 0.001)] and 36% (25%-46%; HR 3.88; p < 0.001) in DS1-2, DS3 and DS4-5, respectively. EOI PET maintained its prognostic value in both the standard and experimental arms. In the whole population, 5-yr OS was 94% (95%CI: 92%-96%), with 96% (95%CI: 94-97
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- 2024
5. Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe
- Author
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Williams, M, Shaw, L, Hirschfeld, C, Maurovich-Horvat, P, Norgaard, B, Pontone, G, Jimenez-Heffernan, A, Sinitsyn, V, Sergienko, V, Ansheles, A, Bax, J, Buechel, R, Milan, E, Slart, R, Nicol, E, Bucciarelli-Ducci, C, Pynda, Y, Better, N, Cerci, R, Dorbala, S, Raggi, P, Villines, T, Vitola, J, Malkovskiy, E, Goebel, B, Cohen, Y, Randazzo, M, Pascual, T, Dondi, M, Paez, D, Einstein, A, Nasery, M, Goda, A, Shirka, E, Benlabgaa, R, Bouyoucef, S, Medjahedi, A, Nailli, Q, Agolti, M, Aguero, R, Del Carmen Alak, M, Alberguina, L, Arronada, G, Astesiano, A, Norton, C, Benteo, P, Blanco, J, Bonelli, J, Bustos, J, Cabrejas, R, Cachero, J, Campisi, R, Canderoli, A, Carames, S, Carrascosa, P, Castro, R, Cendoya, O, Cognigni, L, Collaud, C, Cortes, C, Courtis, J, Cragnolino, D, Daicz, M, De La Vega, A, De Maria, S, Del Riego, H, Dettori, F, Deviggiano, A, Dragonetti, L, Embon, M, Enriquez, R, Ensinas, J, Faccio, F, Facello, A, Garofalo, D, Geronazzo, R, Gonza, N, Gutierrez, L, Guzzo, M, Hasbani, V, Huerin, M, Jager, V, Lewkowicz, J, De Munain, M, Lotti, J, Marquez, A, Masoli, O, Mastrovito, E, Mayoraz, M, Melado, G, Mele, A, Merani, M, Meretta, A, Molteni, S, Montecinos, M, Noguera, E, Novoa, C, Sueldo, C, Ascani, S, Pollono, P, Pujol, M, Radzinschi, A, Raimondi, G, Redruello, M, Rodriguez, M, Romero, R, Acuna, A, Rovaletti, F, Miguel, L, Solari, L, Strada, B, Traverso, S, Traverzo, S, Del Huerto Velazquez Espeche, M, Weihmuller, J, Wolcan, J, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Butler, P, Calcott, J, Carr, L, Chan, V, Chao, C, Chong, W, Dobson, M, Downie, D, Dwivedi, G, Elison, B, Engela, J, Francis, R, Gaikwad, A, Basavaraj, A, Goodwin, B, Greenough, R, Hamilton-Craig, C, Hsieh, V, Joshi, S, Lederer, K, Lee, K, Lee, J, Magnussen, J, Mai, N, Mander, G, Murton, F, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Pathmaraj, K, Pitman, A, Poulter, R, Premaratne, M, Prior, D, Ridley, L, Rutherford, N, Salehi, H, Saunders, C, Scarlett, L, Seneviratne, S, Shetty, D, Shrestha, G, Shulman, J, Solanki, V, Stanton, T, Stuart, M, Stubbs, M, Swainson, I, Taubman, K, Taylor, A, Thomas, P, Unger, S, Upton, A, Vamadevan, S, Van Gaal, W, Verjans, J, Voutnis, D, Wayne, V, Wilson, P, Wong, D, Wong, K, Younger, J, Feuchtner, G, Mirzaei, S, Weiss, K, Maroz-Vadalazhskaya, N, Gheysens, O, Homans, F, Moreno-Reyes, R, Pasquet, A, Roelants, V, Van De Heyning, C, Rios, R, Soldat-Stankovic, V, Stankovic, S, Siqueira, M, Almeida, A, Togni, P, Andrade, J, Andrade, L, Anselmi, C, Araujo, R, Azevedo, G, Bezerra, S, Biancardi, R, Grossman, G, Brandao, S, Pianta, D, Carreira, L, Castro, B, Chang, T, Cunali, F, Cury, R, Dantas, R, De Amorim Fernandes, F, De Lorenzo, A, De MacEdo Filho, R, Erthal, F, Fernandes, F, Fernandes, J, De Souza, T, Alves, W, Ghini, B, Goncalves, L, Gottlieb, I, Hadlich, M, Kameoka, V, Lima, R, Lima, A, Lopes, R, E Silva, R, Magalhaes, T, Silva, F, Mastrocola, L, Medeiros, F, Meneghetti, J, Naue, V, Naves, D, Nolasco, R, Nomura, C, Oliveira, J, Paixao, E, De Carvalho, F, Pinto, I, Possetti, P, Quinta, M, Ramos, R, Rocha, R, Rodrigues, A, Rodrigues, C, Romantini, L, Sanches, A, Santana, S, Da Silva, L, Schvartzman, P, Matushita, C, Senra, T, Shiozaki, A, De Siqueira, M, Siqueira, C, Smanio, P, Soares, C, Soares, J, Bittencourt, M, Spiro, B, Mesquita, C, Torreao, J, Torres, R, Uellendahl, M, Monte, G, Verissimo, O, Cabeda, E, Pedras, F, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Kostadinova, I, Theng, Y, Abikhzer, G, Barette, R, Chow, B, Dabreo, D, Friedrich, M, Garg, R, Hafez, M, Johnson, C, Kiess, M, Leipsic, J, Leung, E, Miller, R, Oikonomou, A, Probst, S, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Canessa, J, Munoz, G, Concha, C, Hidalgo, P, Lovera, C, Massardo, T, Vargas, L, Abad, P, Arturo, H, Ayala, S, Benitez, L, Cadena, A, Caicedo, C, Moncayo, A, Gomez, S, Villamil, C, Jaimes, C, Londono, J, Blair, J, Pabon, L, Pineda, M, Rojas, J, Ruiz, D, Escobar, M, Vasquez, A, Vergel, D, Zuluaga, A, Gamboa, I, Castro, G, Gonzalez, U, Baric, A, Batinic, T, Franceschi, M, Hrabak, M, Jukic, M, Medakovic, P, Persic, V, Prpic, M, Punda, A, Batista, J, Lauchy, J, Gutierrez, Y, Menendez, R, Peix, A, Rochela, L, Panagidis, C, Petrou, I, Engelmann, V, Kaminek, M, Kincl, V, Lang, O, Simanek, M, Abdulla, J, Bottcher, M, Christensen, M, Gormsen, L, Hasbak, P, Hess, S, Holdgaard, P, Johansen, A, Kyhl, K, Ovrehus, K, Sand, N, Steffensen, R, Thomassen, A, Zerahn, B, Perez, A, Velez, G, Velez, M, Aziz, I, Abougabal, M, Ahmed, T, Allam, A, Asfour, A, Hassan, M, Hassan, A, Ibrahim, A, Kaffas, S, Kandeel, A, Ali, M, Mansy, A, Maurice, H, Nabil, S, Shaaban, M, Flores, A, Poksi, A, Knuuti, J, Kokkonen, V, Larikka, M, Uusitalo, V, Bailly, M, Burg, S, Deux, J, Habouzit, V, Hyafil, F, Lairez, O, Proffit, F, Regaieg, H, Sarda-Mantel, L, Tacher, V, Schneider, R, Ayetey, H, Angelidis, G, Archontaki, A, Chatziioannou, S, Datseris, I, Fragkaki, C, Georgoulias, P, Koukouraki, S, Koutelou, M, Kyrozi, E, Repasos, E, Stavrou, P, Valsamaki, P, Gonzalez, C, Gutierrez, G, Maldonado, A, Buga, K, Garai, I, Schmidt, E, Szilveszter, B, Varady, E, Banthia, N, Bhagat, J, Bhargava, R, Bhat, V, Bhatia, M, Choudhury, P, Chowdekar, V, Irodi, A, Jain, S, Joseph, E, Kumar, S, Mahapatra, G, Mitra, D, Mittal, B, Ozair, A, Patel, C, Patel, T, Patel, R, Patel, S, Saxena, S, Sengupta, S, Singh, S, Singh, B, Sood, A, Verma, A, Affandi, E, Alam, P, Edison, E, Gunawan, G, Hapkido, H, Hidayat, B, Huda, A, Mukti, A, Prawiro, D, Soeriadi, E, Syawaluddin, H, Albadr, A, Assadi, M, Emami, F, Houshmand, G, Maleki, M, Rostami, M, Zakavi, S, Zaid, E, Agranovich, S, Arnson, Y, Bar-Shalom, R, Frenkel, A, Knafo, G, Lugassi, R, Moalem, I, Mor, M, Muskal, N, Ranser, S, Shalev, A, Albano, D, Alongi, P, Arnone, G, Bagatin, E, Baldari, S, Bauckneht, M, Bertelli, P, Bianco, F, Bonfiglioli, R, Boni, R, Bruno, A, Bruno, I, Busnardo, E, Califaretti, E, Camoni, L, Carnevale, A, Casoni, R, Cavallo, A, Cavenaghi, G, Chierichetti, F, Chiocchi, M, Cittanti, C, Colletta, M, Conti, U, Cossu, A, Cuocolo, A, Cuzzocrea, M, De Rimini, M, De Vincentis, G, Del Giudice, E, Del Torto, A, Della Tommasina, V, Durmo, R, Erba, P, Evangelista, L, Faletti, R, Faragasso, E, Farsad, M, Ferro, P, Florimonte, L, Frantellizzi, V, Fringuelli, F, Gatti, M, Gaudiano, A, Gimelli, A, Giubbini, R, Giuffrida, F, Ialuna, S, Laudicella, R, Leccisotti, L, Leva, L, Liga, R, Liguori, C, Longo, G, Maffione, M, Mancini, M, Marcassa, C, Nardi, B, Pacella, S, Pepe, G, Pulizzi, S, Quartuccio, N, Rampin, L, Ricci, F, Rossini, P, Rubini, G, Russo, V, Sacchetti, G, Sambuceti, G, Scarano, M, Sciagra, R, Sperandio, M, Stefanelli, A, Ventroni, G, Zoboli, S, Baugh, D, Chambers, D, Madu, E, Nunura, F, Asano, H, Chimura, C, Fujimoto, S, Fujisue, K, Fukunaga, T, Fukushima, Y, Fukuyama, K, Hashimoto, J, Ichikawa, Y, Iguchi, N, Imai, M, Inaki, A, Ishimura, H, Isobe, S, Kadokami, T, Kato, T, Kudo, T, Kumita, S, Maruno, H, Mataki, H, Miyagawa, M, Morimoto, R, Moroi, M, Nagamachi, S, Nakajima, K, Nakata, T, Nakazato, R, Nanasato, M, Naya, M, Norikane, T, Ohta, Y, Okayama, S, Okizaki, A, Otomi, Y, Otsuka, H, Saito, M, Sakata, S, Sarai, M, Sato, D, Shiraishi, S, Suwa, Y, Takanami, K, Takehana, K, Taki, J, Tamaki, N, Taniguchi, Y, Teragawa, H, Tomizawa, N, Tsujita, K, Umeji, K, Wakabayashi, Y, Yamada, S, Yamazaki, S, Yoneyama, T, Rawashdeh, M, Batyrkhanov, D, Dautov, T, Makhdomi, K, Ombati, K, Alkandari, F, Garashi, M, Coie, T, Rajvong, S, Kalinin, A, Kalnina, M, Haidar, M, Komiagiene, R, Kviecinskiene, G, Mataciunas, M, Vajauskas, D, Picard, C, Karim, N, Reichmuth, L, Samuel, A, Allarakha, M, Naojee, A, Alexanderson-Rosas, E, Barragan, E, Becerril, A, Gonzalez-Montecinos, Cabada, M, Rodriguez, D, Carvajal-Juarez, I, Cortes, V, Cortes, F, De La Pena, E, Gama-Moreno, M, Gonzalez, L, Ramirez, N, Jimenez-Santos, M, Matos, L, Monroy, E, Morelos, M, Ornelas, M, Ramirez, J, Preciado-Anaya, A, Preciado-Gutierrez, O, Barragan, 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C., Shaw L., Hirschfeld C. B., Maurovich-Horvat P., Norgaard B. L., Pontone G., Jimenez-Heffernan A., Sinitsyn V., Sergienko V., Ansheles A., Bax J. J., Buechel R., Milan E., Slart R. H. J. A., Nicol E., Bucciarelli-Ducci C., Pynda Y., Better N., Cerci R., Dorbala S., Raggi P., Villines T. C., Vitola J., Malkovskiy E., Goebel B., Cohen Y., Randazzo M., Pascual T. N. B., Dondi M., Paez D., Einstein A. J., Nasery M. N., Goda A., Shirka E., Benlabgaa R., Bouyoucef S., Medjahedi A., Nailli Q., Agolti M., Aguero R. N., Del Carmen Alak M., Alberguina L. G., Arronada G., Astesiano A., Norton C. B., Benteo P., Blanco J., Bonelli J. M., Bustos J. J., Cabrejas R., Cachero J., Campisi R., Canderoli A., Carames S., Carrascosa P., Castro R., Cendoya O., Cognigni L. M., Collaud C., Cortes C., Courtis J., Cragnolino D., Daicz M., De La Vega A., De Maria S. T., Del Riego H., Dettori F., Deviggiano A., Dragonetti L., Embon M., Enriquez R. E., Ensinas J., Faccio F., Facello A., Garofalo D., Geronazzo R., Gonza N., Gutierrez L., Guzzo M. A., Hasbani V., Huerin M., Jager V., Lewkowicz J. M., De Munain M. N. A. L., Lotti J. M., Marquez A., Masoli O., Masoli O. H., Mastrovito E., Mayoraz M., Melado G. E., Mele A., Merani M. F., Meretta A. H., Molteni S., Montecinos M., Noguera E., Novoa C., Sueldo C. P., Ascani S. P., Pollono P., Pujol M. P., Radzinschi A., Raimondi G., Redruello M., Rodriguez M., Romero R. L., Acuna A. R., Rovaletti F., Miguel L. S., Solari L., Strada B., Traverso S., Traverzo S. S., Del Huerto Velazquez Espeche M., Weihmuller J. S., Wolcan J., Zeffiro S., Sakanyan M., Beuzeville S., Boktor R., Butler P., Calcott J., Carr L., Chan V., Chao C., Chong W., Dobson M., Downie D., Dwivedi G., Elison B., Engela J., Francis R., Gaikwad A., Basavaraj A. G., Goodwin B., Greenough R., Hamilton-Craig C., Hsieh V., Joshi S., Lederer K., Lee K., Lee J., Magnussen J., Mai N., Mander G., Murton F., Nandurkar D., Neill J., O'Rourke E., O'Sullivan P., Pandos G., Pathmaraj K., Pitman A., Poulter R., Premaratne M., Prior D., Ridley L., Rutherford N., Salehi H., Saunders C., Scarlett L., Seneviratne S., Shetty D., Shrestha G., Shulman J., Solanki V., Stanton T., Stuart M., Stubbs M., Swainson I., Taubman K., Taylor A., Thomas P., Unger S., Upton A., Vamadevan S., Van Gaal W., Verjans J., Voutnis D., Wayne V., Wilson P., Wong D., Wong K., Younger J., Feuchtner G., Mirzaei S., Weiss K., Maroz-Vadalazhskaya N., Gheysens O., Homans F., Moreno-Reyes R., Pasquet A., Roelants V., Van De Heyning C. M., Rios R. A., Soldat-Stankovic V., Stankovic S., Siqueira M. H. A., Almeida A., Togni P. H. A., Andrade J. H., Andrade L., Anselmi C., Araujo R., Azevedo G., Bezerra S., Biancardi R., Grossman G. B., Brandao S., Pianta D. B., Carreira L., Castro B., Chang T., Cunali F., Cury R., Dantas R., De Amorim Fernandes F., De Lorenzo A., De MacEdo Filho R., Erthal F., Fernandes F., Fernandes J., De Souza T. F., Alves W. F., Ghini B., Goncalves L., Gottlieb I., Hadlich M., Kameoka V., Lima R., Lima A., Lopes R. W., E Silva R. M., Magalhaes T., Silva F. M., Mastrocola L. E., Medeiros F., Meneghetti J. C., Naue V., Naves D., Nolasco R., Nomura C., Oliveira J. B., Paixao E., De Carvalho F. P., Pinto I., Possetti P., Quinta M., Ramos R. R. N., Rocha R., Rodrigues A., Rodrigues C., Romantini L., Sanches A., Santana S., Da Silva L. S., Schvartzman P., Matushita C. S., Senra T., Shiozaki A., De Siqueira M. E. M., Siqueira C., Smanio P., Soares C. E., Soares J., Bittencourt M. S., Spiro B., Mesquita C. T., Torreao J., Torres R., Uellendahl M., Monte G. U., Verissimo O., Cabeda E. V., Pedras F. V., Waltrick R., Zapparoli M., Naseer H., Garcheva-Tsacheva M., Kostadinova I., Theng Y., Abikhzer G., Barette R., Chow B., Dabreo D., Friedrich M., Garg R., Hafez M. N., Johnson C., Kiess M., Leipsic J., Leung E., Miller R., Oikonomou A., Probst S., Roifman I., Small G., Tandon V., Trivedi A., White J., Zukotynski K., Canessa J., Munoz G. C., Concha C., Hidalgo P., Lovera C., Massardo T., Vargas L. S., Abad P., Arturo H., Ayala S., Benitez L., Cadena A., Caicedo C., Moncayo A. C., Gomez S., Villamil C. T. G., Jaimes C., Londono J., Blair J. L. L., Pabon L., Pineda M., Rojas J. C., Ruiz D., Escobar M. V., Vasquez A., Vergel D., Zuluaga A., Gamboa I. B., Castro G., Gonzalez U., Baric A., Batinic T., Franceschi M., Hrabak M., Jukic M., Medakovic P., Persic V., Prpic M., Punda A., Batista J. F., Lauchy J. M. G., Gutierrez Y. M., Menendez R., Peix A., Rochela L., Panagidis C., Petrou I., Engelmann V., Kaminek M., Kincl V., Lang O., Simanek M., Abdulla J., Bottcher M., Christensen M., Gormsen L. C., Hasbak P., Hess S., Holdgaard P., Johansen A., Kyhl K., Ovrehus K. A., Sand N. P. R., Steffensen R., Thomassen A., Zerahn B., Perez A., Velez G. A. E., Velez M. S., Aziz I. S. A., Abougabal M., Ahmed T., Allam A., Asfour A., Hassan M., Hassan A., Ibrahim A., Kaffas S., Kandeel A., Ali M. M., Mansy A., Maurice H., Nabil S., Shaaban M., Flores A. C., Poksi A., Knuuti J., Kokkonen V., Larikka M., Uusitalo V., Bailly M., Burg S., Deux J. -F., Habouzit V., Hyafil F., Lairez O., Proffit F., Regaieg H., Sarda-Mantel L., Tacher V., Schneider R. P., Ayetey H., Angelidis G., Archontaki A., Chatziioannou S., Datseris I., Fragkaki C., Georgoulias P., Koukouraki S., Koutelou M., Kyrozi E., Repasos E., Stavrou P., Valsamaki P., Gonzalez C., Gutierrez G., Maldonado A., Buga K., Garai I., Schmidt E., Szilveszter B., Varady E., Banthia N., Bhagat J. K., Bhargava R., Bhat V., Bhatia M., Choudhury P., Chowdekar V. S., Irodi A., Jain S., Joseph E., Kumar S., Mahapatra G., Mitra D., Mittal B. R., Ozair A., Patel C., Patel T., Patel R., Patel S., Saxena S., Sengupta S., Singh S., Singh B., Sood A., Verma A., Affandi E., Alam P. S., Edison E., Gunawan G., Hapkido H., Hidayat B., Huda A., Mukti A. P., Prawiro D., Soeriadi E. A., Syawaluddin H., Albadr A., Assadi M., Emami F., Houshmand G., Maleki M., Rostami M. T., Zakavi S. R., Zaid E. A., Agranovich S., Arnson Y., Bar-Shalom R., Frenkel A., Knafo G., Lugassi R., Moalem I. S. M., Mor M., Muskal N., Ranser S., Shalev A., Albano D., Alongi P., Arnone G., Bagatin E., Baldari S., Bauckneht M., Bertelli P., Bianco F., Bonfiglioli R., Boni R., Bruno A., Bruno I., Busnardo E., Califaretti E., Camoni L., Carnevale A., Casoni R., Cavallo A. U., Cavenaghi G., Chierichetti F., Chiocchi M., Cittanti C., Colletta M., Conti U., Cossu A., Cuocolo A., Cuzzocrea M., De Rimini M. L., De Vincentis G., Del Giudice E., Del Torto A., Della Tommasina V., Durmo R., Erba P. A., Evangelista L., Faletti R., Faragasso E., Farsad M., Ferro P., Florimonte L., Frantellizzi V., Fringuelli F. M., Gatti M., Gaudiano A., Gimelli A., Giubbini R., Giuffrida F., Ialuna S., Laudicella R., Leccisotti L., Leva L., Liga R., Liguori C., Longo G., Maffione M., Mancini M. E., Marcassa C., Nardi B., Pacella S., Pepe G., Pulizzi S., Quartuccio N., Rampin L., Ricci F., Rossini P., Rubini G., Russo V., Sacchetti G. M., Sambuceti G., Scarano M., Sciagra R., Sperandio M., Stefanelli A., Ventroni G., Zoboli S., Baugh D., Chambers D., Madu E., Nunura F., Asano H., Chimura C. M., Fujimoto S., Fujisue K., Fukunaga T., Fukushima Y., Fukuyama K., Hashimoto J., Ichikawa Y., Iguchi N., Imai M., Inaki A., Ishimura H., Isobe S., Kadokami T., Kato T., Kudo T., Kumita S., Maruno H., Mataki H., Miyagawa M., Morimoto R., Moroi M., Nagamachi S., Nakajima K., Nakata T., Nakazato R., Nanasato M., Naya M., Norikane T., Ohta Y., Okayama S., Okizaki A., Otomi Y., Otsuka H., Saito M., Sakata S. Y., Sarai M., Sato D., Shiraishi S., Suwa Y., Takanami K., Takehana K., Taki J., Tamaki N., Taniguchi Y., Teragawa H., Tomizawa N., Tsujita K., Umeji K., Wakabayashi Y., Yamada S., Yamazaki S., Yoneyama T., Rawashdeh M., Batyrkhanov D., Dautov T., Makhdomi K., Ombati K., Alkandari F., Garashi M., Coie T. L., Rajvong S., Kalinin A., Kalnina M., Haidar M., Komiagiene R., Kviecinskiene G., Mataciunas M., Vajauskas D., Picard C., Karim N. K. A., Reichmuth L., Samuel A., Allarakha M. A., Naojee A. S., Alexanderson-Rosas E., Barragan E., Becerril A., Cabada M., Rodriguez D. C., Carvajal-Juarez I., Cortes V., Cortes F., De La Pena E., Gama-Moreno M., Gonzalez L., Ramirez N. G., Jimenez-Santos M., Matos L., Monroy E., Morelos M., Ornelas M., Ramirez J. A. O., Preciado-Anaya A., Preciado-Gutierrez O. U., Barragan A. P., Uvera S. G. R., Sandoval S., Tomas M. S., Sierra-Galan L. M., Siu S., Vallejo E., Valles M., Faraggi M., Sereegotov E., Ilic S., Ben-Rais N., Alaoui N. I., Taleb S., Myo K. P. P., Thu P. S., Ghimire R. K., Rajbanshi B., Barneveld P., Glaudemans A., Habets J., Koopmans K. P., Manders J., Pool S., Scholte A., Scholtens A., Slart R., Thimister P., Van Asperen E. -J., Veltman N., Verschure D., Wagenaar N., Edmond J., Ellis C., Johnson K., Keenan R., Kueh S. H., Occleshaw C., Sasse A., To A., Van Pelt N., Young C., Cuadra T., Vanegas H. B. R., Soli I. A., Issoufou D. M., Ayodele T., Madu C., Onimode Y., Efros-Monsen E., Forsdahl S. H., Dimmen J. -M. H., Jorgensen A., Krohn I., Lovhaugen P., Braten A. T., Al Dhuhli H., Al Kindi F., Al-Bulushi N., Jawa Z., Tag N., Afzal M. S., Fatima S., Younis M. N., Riaz M., Saadullah M., Herrera Y., Lenturut-Katal D., Vazquez M. C., Ortellado J., Akhter A., Cao D., Cheung S., Dai X., Gong L., Han D., Hou Y., Li C., Li T., Li D., Li S., Liu J., Liu H., Lu B., Ng M. Y., Sun K., Tang G., Wang J., Wang X., Wang Z. -Q., Wang Y., Wu J., Wu Z., Xia L., Xiao J., Xu L., Yang Y., Yin W., Yu J., Yuan L., Zhang T., Zhang L., Zhang Y. -G., Zhang X., Zhu L., Alfaro A., Abrihan P., Barroso A., Cruz E., Gomez M. R., Magboo V. P., Medina J. M., Obaldo J., Pastrana D., Pawhay C. M., Quinon A., Tang J. M., Tecson B., Uson K. J., Uy M., Kostkiewicz M., Kunikowska J., Bettencourt N., Cantinho G., Ferreira A., Syed G., Arnous S., Atyani S., Byrne A., Gleeson T., Kerins D., Meehan C., Murphy D., Murphy M., Murray J., O'Brien J., Bang J. -I., Bom H., Cho S. -G., Hong C. M., Jang S. J., Jeong Y. H., Kang W. J., Kim J. -Y., Namgung C. K., So Y., Won K. S., Majstorov V., Vavlukis M., Salobir B. G., Stalc M., Benedek T., Benedek I., Mititelu R., Stan C. A., Dariy O., Drozdova O., Gagarina N., Gulyaev V. M., Itskovich I., Karalkin A., Kokov A., Migunova E., Pospelov V., Ryzhkova D., Saifullina G., Sazonova S., Shurupova I., Trifonova T., Ussov W. Y., Vakhromeeva M., Valiullina N., Zavadovsky K., Zhuravlev K., Alasnag M., Okarvi S., Saranovic D. S., Keng F., See J. H. J., Sekar R., Yew M. S., Vondrak A., Bejai S., Bennie G., Bester R., Engelbrecht G., Evbuomwan O., Gongxeka H., Vuuren M. J., Kaplan M., Khushica P., Lakhi H., Louw L., Malan N., Milos K., Modiselle M., More S., Naidoo M., Scholtz L., Vangu M., Aguade-Bruix S., Blanco I., Cabrera A., Camarero A., Casans-Tormo I., Cuellar-Calabria H., Flotats A., Canamero M. E. F., Garcia M. E., Leta R., Diaz J. L., Lumbreras L., Marquez-Cabeza J. J., Martin F., De Alegria A. M., Medina F., Canal M. P., Peiro V., Pubul-Nunez V., Madrid J. I. R., Rey C. R., Perez R. R., Ruiz J., Hernandez G. S., Sevilla A., Zeidan N., Nanayakkara D., Udugama C., Simonsson M., Alkadhi H., Buechel R. R., Burger P., Ceriani L., De Boeck B., Grani C., De Saint Lager Lucas A. J., Kamani C. H., Kawel-Boehm N., Manka R., Prior J. O., Rominger A., Vallee J. -P., Khiewvan B., Premprabha T., Thientunyakit T., Sellem A., Kir K. M., Sayman H., Sebikali M. J., Muyinda Z., Kmetyuk Y., Korol P., Mykhalchenko O., Pliatsek V., Satyr M., Albalooshi B., Hassan M. I. A., Anderson J., Bedi P., Biggans T., Bularga A., Bull R., Burgul R., Carpenter J. -P., Coles D., Cusack D., Deshpande A., Dougan J., Fairbairn T., Farrugia A., Gopalan D., Gummow A., Ramkumar P. G., Hamilton M., Harbinson M., Hartley T., Hudson B., Joshi N., Kay M., Kelion A., Khokhar A., Kitt J., Low C., Mak S. M., Marousa N., Martin J., McAlindon E., Menezes L., Morgan-Hughes G., Moss A., Murray A., Patel D., Peebles C., Pugliese F., Rodrigues J. C. L., Rofe C., Sabharwal N., Schofield R., Semple T., Sharma N., Strouhal P., Subedi D., Topping W., Tweed K., Weir-Mccall J., Abbara S., Abbasi T., Abbott B., Abohashem S., Abramson S., Al-Abboud T., Al-Mallah M., Almousalli O., Ananthasubramaniam K., Kumar M. A., Askew J., Attanasio L., Balmer-Swain M., Bayer R. R., Bernheim A., Bhatti S., Bieging E., Blankstein R., Bloom S., Blue S., Bluemke D., Borges A., Branch K., Bravo P., Brothers J., Budoff M., Bullock-Palmer R., Burandt A., Burke F. W., Bush K., Candela C., Capasso E., Cavalcante J., Chang D., Chatterjee S., Chatzizisis Y., Cheezum M., Chen T., Chen J., Chen M., Choi A., Clarcq J., Cordero A., Crim M., Danciu S., Decter B., Dhruva N., Doherty N., Doukky R., Dunbar A., Duvall W., Edwards R., Esquitin K., Farah H., Fentanes E., Ferencik M., Fisher D., Fitzpatrick D., Foster C., Fuisz T., Gannon M., Gastner L., Gerson M., Ghoshhajra B., Goldberg A., Goldner B., Gonzalez J., Gore R., Gracia-Lopez S., Hage F., Haider A., Haider S., Hamirani Y., Hassen K., Hatfield M., Hawkins C., Hawthorne K., Heath N., Hendel R., Hernandez P., Hill G., Horgan S., Huffman J., Hurwitz L., Iskandrian A., Janardhanan R., Jellis C., Jerome S., Kalra D., Kaviratne S., Kay F., Kelly F., Khalique O., Kinkhabwala M., Iii G. K., Kircher J., Kirkbride R., Kontos M., Kottam A., Krepp J., Layer J., Lee S. H., Leppo J., Lesser J., Leung S., Lewin H., Litmanovich D., Liu Y., Lopez-Mattei J., Magurany K., Markowitz J., Marn A., Matis S. E., McKenna M., McRae T., Mendoza F., Merhige M., Min D., Moffitt C., Moncher K., Moore W., Morayati S., Morris M., Mossa-Basha M., Mrsic Z., Murthy V., Nagpal P., Napier K., Narula J., Nelson K., Nijjar P., Osman M., Parwani P., Passen E., Patel A., Patil P., Paul R., Phillips L., Polsani V., Poludasu R., Pomerantz B., Porter T., Prentice R., Pursnani A., Rabbat M., Ramamurti S., Rich F., Luna H. R., Robinson A., Robles K., Rodriguez C., Rorie M., Rumberger J., Russell R., Sabra P., Sadler D., Schemmer M., Schoepf U. J., Shah S., Shah N., Shanbhag S., Sharma G., Shayani S., Shirani J., Shivaram P., Sigman S., Simon M., Slim A., Smith D., Smith A., Soman P., Srichai-Parsia M. B., Streeter J., Albert T., Tawakol A., Thomas D., Thompson R., Torbet T., Trinidad D., Ullery S., Unzek S., Uretsky S., Vallurupalli S., Verma V., Waller A., Wang E., Ward P., Weissman G., Wesbey G., White K., Winchester D., Wolinsky D., Yost S., Zgaljardic M., Alonso O., Beretta M., Ferrando R., Kapitan M., Mut F., Djuraev O., Rozikhodjaeva G., Ngoc H. L., Mai S. H., and Nguyen X. C.
- Abstract
Objectives We aimed to explore the impact of the COVID-19 pandemic on cardiac diagnostic testing and practice and to assess its impact in different regions in Europe. Methods The online survey organised by the International Atomic Energy Agency Division of Human Health collected information on changes in cardiac imaging procedural volumes between March 2019 and March/April 2020. Data were collected from 909 centres in 108 countries. Results Centres in Northern and Southern Europe were more likely to cancel all outpatient activities compared with Western and Eastern Europe. There was a greater reduction in total procedure volumes in Europe compared with the rest of the world in March 2020 (45% vs 41%, p=0.003), with a more marked reduction in Southern Europe (58%), but by April 2020 this was similar in Europe and the rest of the world (69% vs 63%, p=0.261). Regional variations were apparent between imaging modalities, but the largest reductions were in Southern Europe for nearly all modalities. In March 2020, location in Southern Europe was the only independent predictor of the reduction in procedure volume. However, in April 2020, lower gross domestic product and higher COVID-19 deaths were the only independent predictors. Conclusion The first wave of the COVID-19 pandemic had a significant impact on care of patients with cardiac disease, with substantial regional variations in Europe. This has potential long-term implications for patients and plans are required to enable the diagnosis of non-COVID- 19 conditions during the ongoing pandemic.
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- 2021
6. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study
- Author
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Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, A, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De Rimini, M, Deandreis, D, Dottorini, M, Esposito, F, Farsad, M, Gasparini, M, Grana, C, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossini, P, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagra, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, M, Trifiro, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, M, Marzola, M, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei Rossi, F, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, A, Durmo, R, Vellani, C, Ceriani, V, Albano D., Bertagna F., Alongi P., Baldari S., Baldoncini A., Bartolomei M., Boccaletto F., Boero M., Borsatti E., Bruno A., Burroni L., Capoccetti F., Castellani M., Cervino A. R., Chierichetti F., Ciarmiello A., Corso A., Cuocolo A., De Rimini M. L., Deandreis D., Dottorini M. E., Esposito F., Farsad M., Gasparini M., Grana C. M., Gregianin M., Guerra L., Loreti F., Lupi A., Martino G., Milan E., Modoni S., Morbelli S., Muni A., Nicolai E., Palumbo B., Papa S., Papaleo A., Pellerito R., Poti C., Romano P., Rossetti C., Rossini P., Rubini G., Ruffini L., Sacchetti G., Savelli G., Schiavariello S., Sciagra R., Sciuto R., Seregni E., Sestini S., Sicolo M., Spanu A., Storto G., Balducci M. T., Trifiro G., Versari A., Vignati A., Volterrani D., Calcagni M. L., Marzola M. C., Garufo A., Evangelista L., Maroldi R., Schillaci O., Giubbini R., Bonacina M., Laudicella R., Spallino M., Palucci A., Cuzzocrea M., Donner M., Maurea S., Ceci F., Dei Rossi F., Tranfaglia B., Sartorello A., Gandolfo P., Buschiazzo A., Scarale A., Kirienko M., Merenda N., Nappi A. G., Durmo R., Vellani C., Ceriani V., Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, A, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De Rimini, M, Deandreis, D, Dottorini, M, Esposito, F, Farsad, M, Gasparini, M, Grana, C, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossini, P, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagra, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, M, Trifiro, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, M, Marzola, M, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei Rossi, F, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, A, Durmo, R, Vellani, C, Ceriani, V, Albano D., Bertagna F., Alongi P., Baldari S., Baldoncini A., Bartolomei M., Boccaletto F., Boero M., Borsatti E., Bruno A., Burroni L., Capoccetti F., Castellani M., Cervino A. R., Chierichetti F., Ciarmiello A., Corso A., Cuocolo A., De Rimini M. L., Deandreis D., Dottorini M. E., Esposito F., Farsad M., Gasparini M., Grana C. M., Gregianin M., Guerra L., Loreti F., Lupi A., Martino G., Milan E., Modoni S., Morbelli S., Muni A., Nicolai E., Palumbo B., Papa S., Papaleo A., Pellerito R., Poti C., Romano P., Rossetti C., Rossini P., Rubini G., Ruffini L., Sacchetti G., Savelli G., Schiavariello S., Sciagra R., Sciuto R., Seregni E., Sestini S., Sicolo M., Spanu A., Storto G., Balducci M. T., Trifiro G., Versari A., Vignati A., Volterrani D., Calcagni M. L., Marzola M. C., Garufo A., Evangelista L., Maroldi R., Schillaci O., Giubbini R., Bonacina M., Laudicella R., Spallino M., Palucci A., Cuzzocrea M., Donner M., Maurea S., Ceci F., Dei Rossi F., Tranfaglia B., Sartorello A., Gandolfo P., Buschiazzo A., Scarale A., Kirienko M., Merenda N., Nappi A. G., Durmo R., Vellani C., and Ceriani V.
- Abstract
Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.
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- 2021
7. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study
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Albano, Domenico, Bertagna, Francesco, Alongi, Pierpaolo, Baldari, Sergio, Baldoncini, Alfonso, Bartolomei, Mirco, Boccaletto, Franco, Boero, Michele, Borsatti, Eugenio, Bruno, Andrea, Burroni, Luca, Capoccetti, Francesca, Castellani, Massimo, Cervino, Anna Rita, Chierichetti, Franca, Ciarmiello, Andrea, Corso, Angelo, Cuocolo, Alberto, De Rimini, Maria Luisa, Deandreis, Desiree’, Dottorini, Massimo Eugenio, Esposito, Filomena, Farsad, Mohsen, Gasparini, Massimo, Grana, Chiara Maria, Gregianin, Michele, Guerra, Luca, Loreti, Fabio, Lupi, Andrea, Martino, Gianluigi, Milan, Elisa, Modoni, Sergio, Morbelli, Silvia, Muni, Alfredo, Nicolai, Emanuele, Palumbo, Barbara, Papa, Sergio, Papaleo, Alberto, Pellerito, Riccardo, Poti, Carlo, Romano, Pasquale, Rossetti, Claudio, Rossini, Pierluigi, Rubini, Giuseppe, Ruffini, Livia, Sacchetti, Gianmauro, Savelli, Giordano, Schiavariello, Saverio, Sciagrà, Roberto, Sciuto, Rosa, Seregni, Ettore, Sestini, Stelvio, Sicolo, Michele, Spanu, Angela, Storto, Giovanni, Balducci, Massimo Tosti, Trifirò, Giuseppe, Versari, Annibale, Vignati, Alberto, Volterrani, Duccio, Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, Antonio, Evangelista, Laura, Maroldi, Roberto, Schillaci, Orazio, Giubbini, Raffaele, Bonacina, M., Laudicella, R., Spallino, M., Palucci, A., Cuzzocrea, M., Donner, M., Maurea, S., Ceci, F., Dei Rossi, F., Tranfaglia, B., Sartorello, A., Gandolfo, P., Buschiazzo, A., Scarale, A., Kirienko, M., Merenda, N., Nappi, A. G., Durmo, R., Vellani, C., Ceriani, V., Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, A, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De Rimini, M, Deandreis, D, Dottorini, M, Esposito, F, Farsad, M, Gasparini, M, Grana, C, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossini, P, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagra, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, M, Trifiro, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, M, Marzola, M, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei Rossi, F, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, A, Durmo, R, Vellani, C, Ceriani, V, Albano, Domenico, Bertagna, Francesco, Alongi, Pierpaolo, Baldari, Sergio, Baldoncini, Alfonso, Bartolomei, Mirco, Boccaletto, Franco, Boero, Michele, Borsatti, Eugenio, Bruno, Andrea, Burroni, Luca, Capoccetti, Francesca, Castellani, Massimo, Cervino, Anna Rita, Chierichetti, Franca, Ciarmiello, Andrea, Corso, Angelo, Cuocolo, Alberto, De Rimini, Maria Luisa, Deandreis, Desiree', Dottorini, Massimo Eugenio, Esposito, Filomena, Farsad, Mohsen, Gasparini, Massimo, Grana, Chiara Maria, Gregianin, Michele, Guerra, Luca, Loreti, Fabio, Lupi, Andrea, Martino, Gianluigi, Milan, Elisa, Modoni, Sergio, Morbelli, Silvia, Muni, Alfredo, Nicolai, Emanuele, Palumbo, Barbara, Papa, Sergio, Papaleo, Alberto, Pellerito, Riccardo, Poti, Carlo, Romano, Pasquale, Rossetti, Claudio, Rossini, Pierluigi, Rubini, Giuseppe, Ruffini, Livia, Sacchetti, Gianmauro, Savelli, Giordano, Schiavariello, Saverio, Sciagrà, Roberto, Sciuto, Rosa, Seregni, Ettore, Sestini, Stelvio, Sicolo, Michele, Spanu, Angela, Storto, Giovanni, Balducci, Massimo Tosti, Trifirò, Giuseppe, Versari, Annibale, Vignati, Alberto, Volterrani, Duccio, Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, Antonio, Evangelista, Laura, Maroldi, Roberto, Schillaci, Orazio, and Giubbini, Raffaele
- Subjects
Lung Diseases ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Asymptomatic ,Incidental finding ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Pandemic ,Prevalence ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,18F-FDG PET/CT ,COVID-19 ,Incidental findings ,Interstitial pneumonia ,SARS-CoV-2 ,Italy ,Pandemics ,Retrospective Studies ,Lung Diseases, Interstitial ,Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA ,Lung ,medicine.diagnostic_test ,business.industry ,F-FDG PET/CT ,Interstitial lung disease ,Retrospective cohort study ,General Medicine ,medicine.disease ,Pneumonia ,medicine.anatomical_structure ,Radiology Nuclear Medicine and imaging ,Positron emission tomography ,Radiology ,medicine.symptom ,Interstitial ,business - Abstract
Purpose To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p Conclusions A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.
- Published
- 2021
8. Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe
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Williams M. C., Shaw L., Hirschfeld C. B., Maurovich-Horvat P., Norgaard B. L., Pontone G., Jimenez-Heffernan A., Sinitsyn V., Sergienko V., Ansheles A., Bax J. J., Buechel R., Milan E., Slart R. H. J. A., Nicol E., Bucciarelli-Ducci C., Pynda Y., Better N., Cerci R., Dorbala S., Raggi P., Villines T. C., Vitola J., Malkovskiy E., Goebel B., Cohen Y., Randazzo M., Pascual T. N. B., Dondi M., Paez D., Einstein A. J., Nasery M. N., Goda A., Shirka E., Benlabgaa R., Bouyoucef S., Medjahedi A., Nailli Q., Agolti M., Aguero R. N., Del Carmen Alak M., Alberguina L. G., Arronada G., Astesiano A., Norton C. B., Benteo P., Blanco J., Bonelli J. M., Bustos J. J., Cabrejas R., Cachero J., Campisi R., Canderoli A., Carames S., Carrascosa P., Castro R., Cendoya O., Cognigni L. M., Collaud C., Cortes C., Courtis J., Cragnolino D., Daicz M., De La Vega A., De Maria S. T., Del Riego H., Dettori F., Deviggiano A., Dragonetti L., Embon M., Enriquez R. E., Ensinas J., Faccio F., Facello A., Garofalo D., Geronazzo R., Gonza N., Gutierrez L., Guzzo M. A., Hasbani V., Huerin M., Jager V., Lewkowicz J. M., De Munain M. N. A. L., Lotti J. M., Marquez A., Masoli O., Masoli O. H., Mastrovito E., Mayoraz M., Melado G. E., Mele A., Merani M. F., Meretta A. H., Molteni S., Montecinos M., Noguera E., Novoa C., Sueldo C. P., Ascani S. P., Pollono P., Pujol M. P., Radzinschi A., Raimondi G., Redruello M., Rodriguez M., Romero R. L., Acuna A. R., Rovaletti F., Miguel L. S., Solari L., Strada B., Traverso S., Traverzo S. S., Del Huerto Velazquez Espeche M., Weihmuller J. S., Wolcan J., Zeffiro S., Sakanyan M., Beuzeville S., Boktor R., Butler P., Calcott J., Carr L., Chan V., Chao C., Chong W., Dobson M., Downie D., Dwivedi G., Elison B., Engela J., Francis R., Gaikwad A., Basavaraj A. G., Goodwin B., Greenough R., Hamilton-Craig C., Hsieh V., Joshi S., Lederer K., Lee K., Lee J., Magnussen J., Mai N., Mander G., Murton F., Nandurkar D., Neill J., O'Rourke E., O'Sullivan P., Pandos G., Pathmaraj K., Pitman A., Poulter R., Premaratne M., Prior D., Ridley L., Rutherford N., Salehi H., Saunders C., Scarlett L., Seneviratne S., Shetty D., Shrestha G., Shulman J., Solanki V., Stanton T., Stuart M., Stubbs M., Swainson I., Taubman K., Taylor A., Thomas P., Unger S., Upton A., Vamadevan S., Van Gaal W., Verjans J., Voutnis D., Wayne V., Wilson P., Wong D., Wong K., Younger J., Feuchtner G., Mirzaei S., Weiss K., Maroz-Vadalazhskaya N., Gheysens O., Homans F., Moreno-Reyes R., Pasquet A., Roelants V., Van De Heyning C. M., Rios R. A., Soldat-Stankovic V., Stankovic S., Siqueira M. H. A., Almeida A., Togni P. H. A., Andrade J. H., Andrade L., Anselmi C., Araujo R., Azevedo G., Bezerra S., Biancardi R., Grossman G. B., Brandao S., Pianta D. B., Carreira L., Castro B., Chang T., Cunali F., Cury R., Dantas R., De Amorim Fernandes F., De Lorenzo A., De MacEdo Filho R., Erthal F., Fernandes F., Fernandes J., De Souza T. F., Alves W. F., Ghini B., Goncalves L., Gottlieb I., Hadlich M., Kameoka V., Lima R., Lima A., Lopes R. W., E Silva R. M., Magalhaes T., Silva F. M., Mastrocola L. E., Medeiros F., Meneghetti J. C., Naue V., Naves D., Nolasco R., Nomura C., Oliveira J. B., Paixao E., De Carvalho F. P., Pinto I., Possetti P., Quinta M., Ramos R. R. N., Rocha R., Rodrigues A., Rodrigues C., Romantini L., Sanches A., Santana S., Da Silva L. S., Schvartzman P., Matushita C. S., Senra T., Shiozaki A., De Siqueira M. E. M., Siqueira C., Smanio P., Soares C. E., Soares J., Bittencourt M. S., Spiro B., Mesquita C. T., Torreao J., Torres R., Uellendahl M., Monte G. U., Verissimo O., Cabeda E. V., Pedras F. V., Waltrick R., Zapparoli M., Naseer H., Garcheva-Tsacheva M., Kostadinova I., Theng Y., Abikhzer G., Barette R., Chow B., Dabreo D., Friedrich M., Garg R., Hafez M. N., Johnson C., Kiess M., Leipsic J., Leung E., Miller R., Oikonomou A., Probst S., Roifman I., Small G., Tandon V., Trivedi A., White J., Zukotynski K., Canessa J., Munoz G. C., Concha C., Hidalgo P., Lovera C., Massardo T., Vargas L. S., Abad P., Arturo H., Ayala S., Benitez L., Cadena A., Caicedo C., Moncayo A. C., Gomez S., Villamil C. T. G., Jaimes C., Londono J., Blair J. L. L., Pabon L., Pineda M., Rojas J. C., Ruiz D., Escobar M. V., Vasquez A., Vergel D., Zuluaga A., Gamboa I. B., Castro G., Gonzalez U., Baric A., Batinic T., Franceschi M., Hrabak M., Jukic M., Medakovic P., Persic V., Prpic M., Punda A., Batista J. F., Lauchy J. M. G., Gutierrez Y. M., Menendez R., Peix A., Rochela L., Panagidis C., Petrou I., Engelmann V., Kaminek M., Kincl V., Lang O., Simanek M., Abdulla J., Bottcher M., Christensen M., Gormsen L. C., Hasbak P., Hess S., Holdgaard P., Johansen A., Kyhl K., Ovrehus K. A., Sand N. P. R., Steffensen R., Thomassen A., Zerahn B., Perez A., Velez G. A. E., Velez M. S., Aziz I. S. A., Abougabal M., Ahmed T., Allam A., Asfour A., Hassan M., Hassan A., Ibrahim A., Kaffas S., Kandeel A., Ali M. M., Mansy A., Maurice H., Nabil S., Shaaban M., Flores A. C., Poksi A., Knuuti J., Kokkonen V., Larikka M., Uusitalo V., Bailly M., Burg S., Deux J. -F., Habouzit V., Hyafil F., Lairez O., Proffit F., Regaieg H., Sarda-Mantel L., Tacher V., Schneider R. P., Ayetey H., Angelidis G., Archontaki A., Chatziioannou S., Datseris I., Fragkaki C., Georgoulias P., Koukouraki S., Koutelou M., Kyrozi E., Repasos E., Stavrou P., Valsamaki P., Gonzalez C., Gutierrez G., Maldonado A., Buga K., Garai I., Schmidt E., Szilveszter B., Varady E., Banthia N., Bhagat J. K., Bhargava R., Bhat V., Bhatia M., Choudhury P., Chowdekar V. S., Irodi A., Jain S., Joseph E., Kumar S., Mahapatra G., Mitra D., Mittal B. R., Ozair A., Patel C., Patel T., Patel R., Patel S., Saxena S., Sengupta S., Singh S., Singh B., Sood A., Verma A., Affandi E., Alam P. S., Edison E., Gunawan G., Hapkido H., Hidayat B., Huda A., Mukti A. P., Prawiro D., Soeriadi E. A., Syawaluddin H., Albadr A., Assadi M., Emami F., Houshmand G., Maleki M., Rostami M. T., Zakavi S. R., Zaid E. A., Agranovich S., Arnson Y., Bar-Shalom R., Frenkel A., Knafo G., Lugassi R., Moalem I. S. M., Mor M., Muskal N., Ranser S., Shalev A., Albano D., Alongi P., Arnone G., Bagatin E., Baldari S., Bauckneht M., Bertelli P., Bianco F., Bonfiglioli R., Boni R., Bruno A., Bruno I., Busnardo E., Califaretti E., Camoni L., Carnevale A., Casoni R., Cavallo A. U., Cavenaghi G., Chierichetti F., Chiocchi M., Cittanti C., Colletta M., Conti U., Cossu A., Cuocolo A., Cuzzocrea M., De Rimini M. L., De Vincentis G., Del Giudice E., Del Torto A., Della Tommasina V., Durmo R., Erba P. A., Evangelista L., Faletti R., Faragasso E., Farsad M., Ferro P., Florimonte L., Frantellizzi V., Fringuelli F. M., Gatti M., Gaudiano A., Gimelli A., Giubbini R., Giuffrida F., Ialuna S., Laudicella R., Leccisotti L., Leva L., Liga R., Liguori C., Longo G., Maffione M., Mancini M. E., Marcassa C., Nardi B., Pacella S., Pepe G., Pulizzi S., Quartuccio N., Rampin L., Ricci F., Rossini P., Rubini G., Russo V., Sacchetti G. M., Sambuceti G., Scarano M., Sciagra R., Sperandio M., Stefanelli A., Ventroni G., Zoboli S., Baugh D., Chambers D., Madu E., Nunura F., Asano H., Chimura C. M., Fujimoto S., Fujisue K., Fukunaga T., Fukushima Y., Fukuyama K., Hashimoto J., Ichikawa Y., Iguchi N., Imai M., Inaki A., Ishimura H., Isobe S., Kadokami T., Kato T., Kudo T., Kumita S., Maruno H., Mataki H., Miyagawa M., Morimoto R., Moroi M., Nagamachi S., Nakajima K., Nakata T., Nakazato R., Nanasato M., Naya M., Norikane T., Ohta Y., Okayama S., Okizaki A., Otomi Y., Otsuka H., Saito M., Sakata S. Y., Sarai M., Sato D., Shiraishi S., Suwa Y., Takanami K., Takehana K., Taki J., Tamaki N., Taniguchi Y., Teragawa H., Tomizawa N., Tsujita K., Umeji K., Wakabayashi Y., Yamada S., Yamazaki S., Yoneyama T., Rawashdeh M., Batyrkhanov D., Dautov T., Makhdomi K., Ombati K., Alkandari F., Garashi M., Coie T. L., Rajvong S., Kalinin A., Kalnina M., Haidar M., Komiagiene R., Kviecinskiene G., Mataciunas M., Vajauskas D., Picard C., Karim N. K. A., Reichmuth L., Samuel A., Allarakha M. A., Naojee A. S., Alexanderson-Rosas E., Barragan E., Becerril A., Gonzalez-Montecinos, Cabada M., Rodriguez D. C., Carvajal-Juarez I., Cortes V., Cortes F., De La Pena E., Gama-Moreno M., Gonzalez L., Ramirez N. G., Jimenez-Santos M., Matos L., Monroy E., Morelos M., Ornelas M., Ramirez J. A. O., Preciado-Anaya A., Preciado-Gutierrez O. U., Barragan A. P., Uvera S. G. R., Sandoval S., Tomas M. S., Sierra-Galan L. M., Siu S., Vallejo E., Valles M., Faraggi M., Sereegotov E., Ilic S., Ben-Rais N., Alaoui N. I., Taleb S., Myo K. P. P., Thu P. S., Ghimire R. K., Rajbanshi B., Barneveld P., Glaudemans A., Habets J., Koopmans K. P., Manders J., Pool S., Scholte A., Scholtens A., Slart R., Thimister P., Van Asperen E. -J., Veltman N., Verschure D., Wagenaar N., Edmond J., Ellis C., Johnson K., Keenan R., Kueh S. H., Occleshaw C., Sasse A., To A., Van Pelt N., Young C., Cuadra T., Vanegas H. B. R., Soli I. A., Issoufou D. M., Ayodele T., Madu C., Onimode Y., Efros-Monsen E., Forsdahl S. H., Dimmen J. -M. H., Jorgensen A., Krohn I., Lovhaugen P., Braten A. T., Al Dhuhli H., Al Kindi F., Al-Bulushi N., Jawa Z., Tag N., Afzal M. S., Fatima S., Younis M. N., Riaz M., Saadullah M., Herrera Y., Lenturut-Katal D., Vazquez M. C., Ortellado J., Akhter A., Cao D., Cheung S., Dai X., Gong L., Han D., Hou Y., Li C., Li T., Li D., Li S., Liu J., Liu H., Lu B., Ng M. Y., Sun K., Tang G., Wang J., Wang X., Wang Z. -Q., Wang Y., Wu J., Wu Z., Xia L., Xiao J., Xu L., Yang Y., Yin W., Yu J., Yuan L., Zhang T., Zhang L., Zhang Y. -G., Zhang X., Zhu L., Alfaro A., Abrihan P., Barroso A., Cruz E., Gomez M. R., Magboo V. P., Medina J. M., Obaldo J., Pastrana D., Pawhay C. M., Quinon A., Tang J. M., Tecson B., Uson K. J., Uy M., Kostkiewicz M., Kunikowska J., Bettencourt N., Cantinho G., Ferreira A., Syed G., Arnous S., Atyani S., Byrne A., Gleeson T., Kerins D., Meehan C., Murphy D., Murphy M., Murray J., O'Brien J., Bang J. -I., Bom H., Cho S. -G., Hong C. M., Jang S. J., Jeong Y. H., Kang W. J., Kim J. -Y., Namgung C. K., So Y., Won K. S., Majstorov V., Vavlukis M., Salobir B. G., Stalc M., Benedek T., Benedek I., Mititelu R., Stan C. A., Dariy O., Drozdova O., Gagarina N., Gulyaev V. M., Itskovich I., Karalkin A., Kokov A., Migunova E., Pospelov V., Ryzhkova D., Saifullina G., Sazonova S., Shurupova I., Trifonova T., Ussov W. Y., Vakhromeeva M., Valiullina N., Zavadovsky K., Zhuravlev K., Alasnag M., Okarvi S., Saranovic D. S., Keng F., See J. H. J., Sekar R., Yew M. S., Vondrak A., Bejai S., Bennie G., Bester R., Engelbrecht G., Evbuomwan O., Gongxeka H., Vuuren M. J., Kaplan M., Khushica P., Lakhi H., Louw L., Malan N., Milos K., Modiselle M., More S., Naidoo M., Scholtz L., Vangu M., Aguade-Bruix S., Blanco I., Cabrera A., Camarero A., Casans-Tormo I., Cuellar-Calabria H., Flotats A., Canamero M. E. F., Garcia M. E., Leta R., Diaz J. L., Lumbreras L., Marquez-Cabeza J. J., Martin F., De Alegria A. M., Medina F., Canal M. P., Peiro V., Pubul-Nunez V., Madrid J. I. R., Rey C. R., Perez R. R., Ruiz J., Hernandez G. S., Sevilla A., Zeidan N., Nanayakkara D., Udugama C., Simonsson M., Alkadhi H., Buechel R. R., Burger P., Ceriani L., De Boeck B., Grani C., De Saint Lager Lucas A. J., Kamani C. H., Kawel-Boehm N., Manka R., Prior J. O., Rominger A., Vallee J. -P., Khiewvan B., Premprabha T., Thientunyakit T., Sellem A., Kir K. M., Sayman H., Sebikali M. J., Muyinda Z., Kmetyuk Y., Korol P., Mykhalchenko O., Pliatsek V., Satyr M., Albalooshi B., Hassan M. I. A., Anderson J., Bedi P., Biggans T., Bularga A., Bull R., Burgul R., Carpenter J. -P., Coles D., Cusack D., Deshpande A., Dougan J., Fairbairn T., Farrugia A., Gopalan D., Gummow A., Ramkumar P. G., Hamilton M., Harbinson M., Hartley T., Hudson B., Joshi N., Kay M., Kelion A., Khokhar A., Kitt J., Low C., Mak S. M., Marousa N., Martin J., McAlindon E., Menezes L., Morgan-Hughes G., Moss A., Murray A., Patel D., Peebles C., Pugliese F., Rodrigues J. C. L., Rofe C., Sabharwal N., Schofield R., Semple T., Sharma N., Strouhal P., Subedi D., Topping W., Tweed K., Weir-Mccall J., Abbara S., Abbasi T., Abbott B., Abohashem S., Abramson S., Al-Abboud T., Al-Mallah M., Almousalli O., Ananthasubramaniam K., Kumar M. A., Askew J., Attanasio L., Balmer-Swain M., Bayer R. R., Bernheim A., Bhatti S., Bieging E., Blankstein R., Bloom S., Blue S., Bluemke D., Borges A., Branch K., Bravo P., Brothers J., Budoff M., Bullock-Palmer R., Burandt A., Burke F. W., Bush K., Candela C., Capasso E., Cavalcante J., Chang D., Chatterjee S., Chatzizisis Y., Cheezum M., Chen T., Chen J., Chen M., Choi A., Clarcq J., Cordero A., Crim M., Danciu S., Decter B., Dhruva N., Doherty N., Doukky R., Dunbar A., Duvall W., Edwards R., Esquitin K., Farah H., Fentanes E., Ferencik M., Fisher D., Fitzpatrick D., Foster C., Fuisz T., Gannon M., Gastner L., Gerson M., Ghoshhajra B., Goldberg A., Goldner B., Gonzalez J., Gore R., Gracia-Lopez S., Hage F., Haider A., Haider S., Hamirani Y., Hassen K., Hatfield M., Hawkins C., Hawthorne K., Heath N., Hendel R., Hernandez P., Hill G., Horgan S., Huffman J., Hurwitz L., Iskandrian A., Janardhanan R., Jellis C., Jerome S., Kalra D., Kaviratne S., Kay F., Kelly F., Khalique O., Kinkhabwala M., Iii G. K., Kircher J., Kirkbride R., Kontos M., Kottam A., Krepp J., Layer J., Lee S. H., Leppo J., Lesser J., Leung S., Lewin H., Litmanovich D., Liu Y., Lopez-Mattei J., Magurany K., Markowitz J., Marn A., Matis S. E., McKenna M., McRae T., Mendoza F., Merhige M., Min D., Moffitt C., Moncher K., Moore W., Morayati S., Morris M., Mossa-Basha M., Mrsic Z., Murthy V., Nagpal P., Napier K., Narula J., Nelson K., Nijjar P., Osman M., Parwani P., Passen E., Patel A., Patil P., Paul R., Phillips L., Polsani V., Poludasu R., Pomerantz B., Porter T., Prentice R., Pursnani A., Rabbat M., Ramamurti S., Rich F., Luna H. R., Robinson A., Robles K., Rodriguez C., Rorie M., Rumberger J., Russell R., Sabra P., Sadler D., Schemmer M., Schoepf U. J., Shah S., Shah N., Shanbhag S., Sharma G., Shayani S., Shirani J., Shivaram P., Sigman S., Simon M., Slim A., Smith D., Smith A., Soman P., Srichai-Parsia M. B., Streeter J., Albert T., Tawakol A., Thomas D., Thompson R., Torbet T., Trinidad D., Ullery S., Unzek S., Uretsky S., Vallurupalli S., Verma V., Waller A., Wang E., Ward P., Weissman G., Wesbey G., White K., Winchester D., Wolinsky D., Yost S., Zgaljardic M., Alonso O., Beretta M., Ferrando R., Kapitan M., Mut F., Djuraev O., Rozikhodjaeva G., Ngoc H. L., Mai S. H., Nguyen X. 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P, Osman, M, Parwani, P, Passen, E, Patel, A, Patil, P, Paul, R, Phillips, L, Polsani, V, Poludasu, R, Pomerantz, B, Porter, T, Prentice, R, Pursnani, A, Rabbat, M, Ramamurti, S, Rich, F, Luna, H, Robinson, A, Robles, K, Rodriguez, C, Rorie, M, Rumberger, J, Russell, R, Sabra, P, Sadler, D, Schemmer, M, Schoepf, U, Shah, S, Shah, N, Shanbhag, S, Sharma, G, Shayani, S, Shirani, J, Shivaram, P, Sigman, S, Simon, M, Slim, A, Smith, D, Smith, A, Soman, P, Srichai-Parsia, M, Streeter, J, Albert, T, Tawakol, A, Thomas, D, Thompson, R, Torbet, T, Trinidad, D, Ullery, S, Unzek, S, Uretsky, S, Vallurupalli, S, Verma, V, Waller, A, Wang, E, Ward, P, Weissman, G, Wesbey, G, White, K, Winchester, D, Wolinsky, D, Yost, S, Zgaljardic, M, Alonso, O, Beretta, M, Ferrando, R, Kapitan, M, Mut, F, Djuraev, O, Rozikhodjaeva, G, Ngoc, H, Mai, S, Nguyen, X, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Translational Immunology Groningen (TRIGR), and Cardiovascular Centre (CVC)
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INCAPS COVID Investigators Group ,cardiac imaging techniques ,Settore MED/11 - Malattie dell'Apparato Cardiovascolare ,Practice Patterns ,Disease ,Cardiovascular ,coronary artery disease ,COVID-19 ,Cardiac Imaging Techniques ,Cardiologists ,Europe ,Health Care Surveys ,Healthcare Disparities ,Heart Diseases ,Humans ,Practice Patterns, Physicians' ,Predictive Value of Tests ,Gross domestic product ,Human health ,cardiovascular disease ,Pandemic ,Medicine ,cardiovascular imaging ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina ,cardiac imaging technique ,Predictive value of tests ,Cardiology and Cardiovascular Medicine ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Infektologija ,cardiac disease ,Coronavirus disease 2019 (COVID-19) ,Independent predictor ,cardiac imaging ,NO ,Imaging diagnosis ,Diseases of the circulatory (Cardiovascular) system ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine ,Physicians' ,business.industry ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Infectology ,RC666-701 ,HOSPITALIZATIONS ,business ,Health Care Delivery, Economics and Global Health Care ,Demography - Abstract
ObjectivesWe aimed to explore the impact of the COVID-19 pandemic on cardiac diagnostic testing and practice and to assess its impact in different regions in Europe.MethodsThe online survey organised by the International Atomic Energy Agency Division of Human Health collected information on changes in cardiac imaging procedural volumes between March 2019 and March/April 2020. Data were collected from 909 centres in 108 countries.ResultsCentres in Northern and Southern Europe were more likely to cancel all outpatient activities compared with Western and Eastern Europe. There was a greater reduction in total procedure volumes in Europe compared with the rest of the world in March 2020 (45% vs 41%, p=0.003), with a more marked reduction in Southern Europe (58%), but by April 2020 this was similar in Europe and the rest of the world (69% vs 63%, p=0.261). Regional variations were apparent between imaging modalities, but the largest reductions were in Southern Europe for nearly all modalities. In March 2020, location in Southern Europe was the only independent predictor of the reduction in procedure volume. However, in April 2020, lower gross domestic product and higher COVID-19 deaths were the only independent predictors.ConclusionThe first wave of the COVID-19 pandemic had a significant impact on care of patients with cardiac disease, with substantial regional variations in Europe. This has potential long-term implications for patients and plans are required to enable the diagnosis of non-COVID-19 conditions during the ongoing pandemic.
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- 2021
9. COMBINED USE OF MINIMAL RESIDUAL DISEASE MONITORING AND FDG‐PET FOR OUTCOME PREDICTION IN FOLLICULAR LYMPHOMA: RESULTS FROM THE FONDAZIONE ITALIANA LINFOMI (FIL) FOLL12 TRIAL.
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Ferrero, S., Assanto, G. M., Durmo, R., Marcheselli, L., Mantoan, B., Pironti, M., Guerra, L., Boccomini, C., Puccini, B., Pulsoni, A., Pavone, V., Arcari, A., Califano, C., Castellino, C., Bari, A., Conconi, A., Dardanis, D., Chauvie, S., Gattei, V., and Del Giudice, I.
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FOLLICULAR lymphoma ,POSITRON emission tomography ,NON-Hodgkin's lymphoma - Abstract
B Discussion: b MRD analysis and PET scan are independent and complementary prognostic tools in FL: a MRD positivity in the two years after immuno-chemotherapy is predictive of POD24 and dismal PFS independently from the EoI PET result. This means that patients scoring PET- at EoI but showing a persistent or reappearing MRD+ signal during the following 24 months had a dismal PFS, superimposable to that of PET+ patients (Figure 1C). B Introduction: b In follicular lymphoma (FL), FDG-PET is routinely employed to evaluate response at the end of induction (EoI), while minimal residual disease (MRD) analysis is highly reliable in predicting relapse over the entire disease history. [Extracted from the article]
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- 2023
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10. PROGNOSTIC ROLE OF LESION DISSEMINATION FEATURE (DMAX) CALCULATED ON BASELINE PET/CT IN HODGKIN LYMPHOMA
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Durmo, R, primary, Ségolèn Cottereau, A, additional, Rebaud, L, additional, Nioche, C, additional, Ruffini, A, additional, Fioroni, F, additional, Meignan, M, additional, Buvat, I, additional, Merli, F, additional, Versari, A, additional, and Luminari, S, additional
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- 2021
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11. EARLY METABOLIC RESPONSE IN FOLLICULAR LYMPHOMA: A SUBSET ANALYSIS OF THE FOLL12 TRIAL BY THE FONDAZIONE ITALIANA LINFOMI (FIL)
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Luminari, S., primary, Guerra, L., additional, Durmo, R., additional, Chauvie, S., additional, Peano, S., additional, Franceschetto, A., additional, Fallanca, F., additional, Tarantino, V., additional, Pinto, A., additional, Ghiggi, C., additional, Pulsoni, A., additional, Merli, M., additional, Farina, L., additional, Tani, M., additional, Botto, B., additional, Musuraca, G., additional, Falini, B., additional, Ballerini, F., additional, Stefani, P. M., additional, Bolis, S., additional, Pietrantuono, G., additional, Manni, M., additional, Marcheselli, L., additional, Federico, M., additional, and Versari, A., additional
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- 2021
- Full Text
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12. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia: The IAEA INCAPS-COVID Study
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Kudo, T., Lahey, R., Hirschfeld, C.B., Williams, M.C., Lu, B., Alasnag, M., Bhatia, M., Henry Bom, H.-., Dautov, T., Fazel, R., Karthikeyan, G., Keng, F.Y.J., Rubinshtein, R., Better, N., Cerci, R.J., Dorbala, S., Raggi, P., Shaw, L.J., Villines, T.C., Vitola, J.V., Choi, A.D., Malkovskiy, E., Goebel, B., Cohen, Y.A., Randazzo, M., Pascual, T.N.B., Pynda, Y., Dondi, M., Paez, D., Einstein, A.J., Cerci, R., Hinterleitner, G., Lu, Y., Morozova, O., Xu, Z., Cohen, Y., Choi, A., Lopez-Mattei, J., Parwani, P., Nasery, M.N., Goda, A., Shirka, E., Benlabgaa, R., Bouyoucef, S., Medjahedi, A., Nailli, Q., Agolti, M., Aguero, R.N., Alak, M.D.C., Alberguina, L.G., Arronada, G., Astesiano, A., Norton, C.B., Benteo, P., Blanco, J., Bonelli, J.M., Bustos, J.J., Cabrejas, R., Cachero, J., Campisi, R., Canderoli, A., Carames, S., Carrascosa, P., Castro, R., Cendoya, O., Cognigni, L.M., Collaud, C., Cortes, C., Courtis, J., Cragnolino, D., Daicz, M., De La Vega, A., De Maria, S.T., Del Riego, H., Dettori, F., Deviggiano, A., Dragonetti, L., Embon, M., Enriquez, R.E., Ensinas, J., Faccio, F., Facello, A., Garofalo, D., Geronazzo, R., Gonza, N., Gutierrez, L., Guzzo, M.A., Hasbani, V., Huerin, M., Jager, V., Lewkowicz, J.M., Lopez De Munain, M.N.A., Lotti, J.M., Marquez, A., Masoli, O., Masoli, O.H., Mastrovito, E., Mayoraz, M., Melado, G.E., Mele, A., Merani, M.F., Meretta, A.H., Molteni, S., Montecinos, M., Noguera, E., Novoa, C., Sueldo, C.P., Ascani, S.P., Pollono, P., Pujol, M.P., Radzinschi, A., Raimondi, G., Redruello, M., Rodriguez, M., Romero, R.L., Acuna, A.R., Rovaletti, F., San Miguel, L., Solari, L., Strada, B., Traverso, S., Traverzo, S.S., Espeche, M.D.H.V., Weihmuller, J.S., Wolcan, J., Zeffiro, S., Sakanyan, M., Beuzeville, S., Boktor, R., Butler, P., Calcott, J., Carr, L., Chan, V., Chao, C., Chong, W., Dobson, M., Downie, D.A., Dwivedi, G., Elison, B., Engela, J., Francis, R., Gaikwad, A., Basavaraj, A.G., Goodwin, B., Greenough, R., Hamilton-Craig, C., Hsieh, V., Joshi, S., Lederer, K., Lee, K., Lee, J., Magnussen, J., Mai, N., Mander, G., Murton, F., Nandurkar, D., Neill, J., O'Rourke, E., O'Sullivan, P., Pandos, G., Pathmaraj, K., Pitman, A., Poulter, R., Premaratne, M., Prior, D., Ridley, L., Rutherford, N., Salehi, H., Saunders, C., Scarlett, L., Seneviratne, S., Shetty, D., Shrestha, G., Shulman, J., Solanki, V., Stanton, T., Stuart, M., Stubbs, M., Swainson, I., Taubman, K., Taylor, A., Thomas, P., Unger, S., Upton, A., Vamadevan, S., Van Gaal, W., Verjans, J., Voutnis, D., Wayne, V., Wilson, P., Wong, D., Wong, K., Younger, J., Feuchtner, G., Mirzaei, S., Weiss, K., Maroz-Vadalazhskaya, N., Gheysens, O., Homans, F., Moreno-Reyes, R., Pasquet, A., Roelants, V., Van De Heyning, C.M., Rios, R.A., Soldat-Stankovic, V., Stankovic, S., Albernaz Siqueira, M.H., Almeida, A., Alves Togni, P.H., Andrade, J.H., Andrade, L., Anselmi, C., Araujo, R., Azevedo, G., Bezerra, S., Biancardi, R., Grossman, G.B., Brandao, S., Pianta, D.B., Carreira, L., Castro, B., Chang, T., Cunali, F., Cury, R., Dantas, R., de Amorim Fernandes, F., De Lorenzo, A., De Macedo Filho, R., Erthal, F., Fernandes, F., Fernandes, J., De Souza, T.F., Alves, W.F., Ghini, B., Goncalves, L., Gottlieb, I., Hadlich, M., Kameoka, V., Lima, R., Lima, A., Lopes, R.W., Machado e Silva, R., Magalhaes, T., Silva, F.M., Mastrocola, L.E., Medeiros, F., Meneghetti, J.C., Naue, V., Naves, D., Nolasco, R., Nomura, C., Oliveira, J.B., Paixao, E., De Carvalho, F.P., Pinto, I., Possetti, P., Quinta, M., Nogueira Ramos, R.R., Rocha, R., Rodrigues, A., Rodrigues, C., Romantini, L., Sanches, A., Santana, S., Sara da Silva, L., Schvartzman, P., Matushita, C.S., Senra, T., Shiozaki, A., Menezes de Siqueira, M.E., Siqueira, C., Smanio, P., Soares, C.E., Junior, J.S., Bittencourt, M.S., Spiro, B., Mesquita, C.T., Torreao, J., Torres, R., Uellendahl, M., Monte, G.U., Verissimo, O., Cabeda, E.V., Pedras, F.V., Waltrick, R., Zapparoli, M., Naseer, H., Garcheva-Tsacheva, M., Kostadinova, I., Theng, Y., Abikhzer, G., Barette, R., Chow, B., Dabreo, D., Friedrich, M., Garg, R., Hafez, M.N., Johnson, C., Kiess, M., Leipsic, J., Leung, E., Miller, R., Oikonomou, A., Probst, S., Roifman, I., Small, G., Tandon, V., Trivedi, A., White, J., Zukotynski, K., Canessa, J., Munoz, G.C., Concha, C., Hidalgo, P., Lovera, C., Massardo, T., Vargas, L.S., Abad, P., Arturo, H., Ayala, S., Benitez, L., Cadena, A., Caicedo, C., Moncayo, A.C., Gomez, S., Gutierrez Villamil, C.T., Jaimes, C., Londono, J., Londono Blair, J.L., Pabon, L., Pineda, M., Rojas, J.C., Ruiz, D., Escobar, M.V., Vasquez, A., Vergel, D., Zuluaga, A., Gamboa, I.B., Castro, G., Gonzalez, U., Baric, A., Batinic, T., Franceschi, M., Paar, M.H., Jukic, M., Medakovic, P., Persic, V., Prpic, M., Punda, A., Batista, J.F., Gomez Lauchy, J.M., Gutierrez, Y.M., Menendez, R., Peix, A., Rochela, L., Panagidis, C., Petrou, I., Engelmann, V., Kaminek, M., Kincl, V., Lang, O., Simanek, M., Abdulla, J., Bottcher, M., Christensen, M., Gormsen, L.C., Hasbak, P., Hess, S., Holdgaard, P., Johansen, A., Kyhl, K., Norgaard, B.L., Ovrehus, K.A., Ronnow Sand, N.P., Steffensen, R., Thomassen, A., Zerahn, B., Perez, A., Escorza Velez, G.A., Velez, M.S., Abdel Aziz, I.S., Abougabal, M., Ahmed, T., Allam, A., Asfour, A., Hassan, M., Hassan, A., Ibrahim, A., Kaffas, S., Kandeel, A., Ali, M.M., Mansy, A., Maurice, H., Nabil, S., Shaaban, M., Flores, A.C., Poksi, A., Knuuti, J., Kokkonen, V., Larikka, M., Uusitalo, V., Bailly, M., Burg, S., Deux, J.-., Habouzit, V., Hyafil, F., Lairez, O., Proffit, F., Regaieg, H., Sarda-Mantel, L., Tacher, V., Schneider, R.P., Ayetey, H., Angelidis, G., Archontaki, A., Chatziioannou, S., Datseris, I., Fragkaki, C., Georgoulias, P., Koukouraki, S., Koutelou, M., Kyrozi, E., Repasos, E., Stavrou, P., Valsamaki, P., Gonzalez, C., Gutierrez, G., Maldonado, A., Buga, K., Garai, I., Maurovich-Horvat, P., Schmidt, E., Szilveszter, B., Varady, E., Banthia, N., Bhagat, J.K., Bhargava, R., Bhat, V., Choudhury, P., Chowdekar, V.S., Irodi, A., Jain, S., Joseph, E., Kumar, S., Girijanandan Mahapatra, P.D., Mitra, D., Mittal, B.R., Ozair, A., Patel, C., Patel, T., Patel, R., Patel, S., Saxena, S., Sengupta, S., Singh, S., Singh, B., Sood, A., Verma, A., Affandi, E., Alam, P.S., Edison, E., Gunawan, G., Hapkido, H., Hidayat, B., Huda, A., Mukti, A.P., Prawiro, D., Soeriadi, E.A., Syawaluddin, H., Albadr, A., Assadi, M., Emami, F., Houshmand, G., Maleki, M., Rostami, M.T., Zakavi, S.R., Zaid, E.A., Agranovich, S., Arnson, Y., Bar-Shalom, R., Frenkel, A., Knafo, G., Lugassi, R., Maor Moalem, I.S., Mor, M., Muskal, N., Ranser, S., Shalev, A., Albano, D., Alongi, P., Arnone, G., Bagatin, E., Baldari, S., Bauckneht, M., Bertelli, P., Bianco, F., Bonfiglioli, R., Boni, R., Bruno, A., Bruno, I., Busnardo, E., Califaretti, E., Camoni, L., Carnevale, A., Casoni, R., Cavallo, A.U., Cavenaghi, G., Chierichetti, F., Chiocchi, M., Cittanti, C., Colletta, M., Conti, U., Cossu, A., Cuocolo, A., Cuzzocrea, M., De Rimini, M.L., De Vincentis, G., Del Giudice, E., Del Torto, A., Della Tommasina, V., Durmo, R., Erba, P.A., Evangelista, L., Faletti, R., Faragasso, E., Farsad, M., Ferro, P., Florimonte, L., Frantellizzi, V., Fringuelli, F.M., Gatti, M., Gaudiano, A., Gimelli, A., Giubbini, R., Giuffrida, F., Ialuna, S., Laudicella, R., Leccisotti, L., Leva, L., Liga, R., Liguori, C., Longo, G., Maffione, M., Mancini, M.E., Marcassa, C., Milan, E., Nardi, B., Pacella, S., Pepe, G., Pontone, G., Pulizzi, S., Quartuccio, N., Rampin, L., Ricci, F., Rossini, P., Rubini, G., Russo, V., Sacchetti, G.M., Sambuceti, G., Scarano, M., Sciagra, R., Sperandio, M., Stefanelli, A., Ventroni, G., Zoboli, S., Baugh, D., Chambers, D., Madu, E., Nunura, F., Asano, H., Chimura, C.M., Fujimoto, S., Fujisue, K., Fukunaga, T., Fukushima, Y., Fukuyama, K., Hashimoto, J., Ichikawa, Y., Iguchi, N., Imai, M., Inaki, A., Ishimura, H., Isobe, S., Kadokami, T., Kato, T., Kumita, S., Maruno, H., Mataki, H., Miyagawa, M., Morimoto, R., Moroi, M., Nagamachi, S., Nakajima, K., Nakata, T., Nakazato, R., Nanasato, M., Naya, M., Norikane, T., Ohta, Y., Okayama, S., Okizaki, A., Otomi, Y., Otsuka, H., Saito, M., Sakata, S.Y., Sarai, M., Sato, D., Shiraishi, S., Suwa, Y., Takanami, K., Takehana, K., Taki, J., Tamaki, N., Taniguchi, Y., Teragawa, H., Tomizawa, N., Tsujita, K., Umeji, K., Wakabayashi, Y., Yamada, S., Yamazaki, S., Yoneyama, T., Rawashdeh, M., Batyrkhanov, D., Makhdomi, K., Ombati, K., Alkandari, F., Garashi, M., Coie, T.L., Rajvong, S., Kalinin, A., Kalnina, M., Haidar, M., Komiagiene, R., Kviecinskiene, G., Mataciunas, M., Vajauskas, D., Picard, C., Karim, N.K.A., Reichmuth, L., Samuel, A., Allarakha, M.A., Naojee, A.S., Alexanderson-Rosas, E., Barragan, E., Gonzalez-Montecinos, A.B., Cabada, M., Rodriguez, D.C., Carvajal-Juarez, I., Cortes, V., Cortes, F., De La Pena, E., Gama-Moreno, M., Gonzalez, L., Ramirez, N.G., Jimenez-Santos, M., Matos, L., Monroy, E., Morelos, M., Ornelas, M., Ortga Ramirez, J.A., Preciado-Anaya, A., Preciado-Gutierrez, O.U., Barragan, A.P., Rosales Uvera, S.G., Sandoval, S., Tomas, M.S., Sierra-Galan, L.M., Siu, S., Vallejo, E., Valles, M., Faraggi, M., Sereegotov, E., Ilic, S., Ben-Rais, N., Alaoui, N.I., Taleb, S., Pa Myo, K.P., Thu, P.S., Ghimire, R.K., Rajbanshi, B., Barneveld, P., Glaudemans, A., Habets, J., Koopmans, K.P., Manders, J., Pool, S., Scholte, A., Scholtens, A., Slart, R., Thimister, P., Van Asperen, E.-., Veltman, N., Verschure, D., Wagenaar, N., Edmond, J., Ellis, C., Johnson, K., Keenan, R., Kueh, S.H.A., Occleshaw, C., Sasse, A., To, A., Van Pelt, N., Young, C., Cuadra, T., Roque Vanegas, H.B., Soli, I.A., Issoufou, D.M., Ayodele, T., Madu, C., Onimode, Y., Efros-Monsen, E., Forsdahl, S.H., Hildre Dimmen, J.-., Jorgensen, A., Krohn, I., Lovhaugen, P., Braten, A.T., Al Dhuhli, H., Al Kindi, F., Al-Bulushi, N., Jawa, Z., Tag, N., Afzal, M.S., Fatima, S., Younis, M.N., Riaz, M., Saadullah, M., Herrera, Y., Lenturut-Katal, D., Vazquez, M.C., Ortellado, J., Akhter, A., Cao, D., Cheung, S., Dai, X., Gong, L., Han, D., Hou, Y., Li, C., Li, T., Li, D., Li, S., Liu, J., Liu, H., M. Y., N., Sun, K., Tang, G., Wang, J., Wang, X., Wang, Z.-., Wang, Y., Wu, J., Wu, Z., Xia, L., Xiao, J., Xu, L., Yang, Y., Yin, W., Yu, J., Yuan, L., Zhang, T., Zhang, L., Zhang, Y.-., Zhang, X., Zhu, L., Alfaro, A., Abrihan, P., Barroso, A., Cruz, E., Gomez, M.R., Magboo, V.P., Medina, J.M., Obaldo, J., Pastrana, D., Pawhay, C.M., Quinon, A., Tang, J.M., Tecson, B., Uson, K.J., Uy, M., Kostkiewicz, M., Kunikowska, J., Bettencourt, N., Cantinho, G., Ferreira, A., Syed, G., Arnous, S., Atyani, S., Byrne, A., Gleeson, T., Kerins, D., Meehan, C., Murphy, D., Murphy, M., Murray, J., O'Brien, J., Bang, J.-., Bom, H., Cho, S.-., Hong, C.M., Jang, S.J., Jeong, Y.H., Kang, W.J., Kim, J.-., Namgung, C.K., So, Y., Won, K.S., Majstorov, V., Vavlukis, M., Salobir, B.G., Stalc, M., Benedek, T., Benedek, I., Mititelu, R., Stan, C.A., Ansheles, A., Dariy, O., Drozdova, O., Gagarina, N., Gulyaev, V.M., Itskovich, I., Karalkin, A., Kokov, A., Migunova, E., Pospelov, V., Ryzhkova, D., Saifullina, G., Sazonova, S., Sergienko, V., Shurupova, I., Trifonova, T., Ussov, W.Y., Vakhromeeva, M., Valiullina, N., Zavadovsky, K., Zhuravlev, K., Okarvi, S., Saranovic, D.S., Keng, F., Jason See, J.H., Sekar, R., Yew, M.S., Vondrak, A., Bejai, S., Bennie, G., Bester, R., Engelbrecht, G., Evbuomwan, O., Gongxeka, H., Vuuren, M.J., Kaplan, M., Khushica, P., Lakhi, H., Louw, L., Malan, N., Milos, K., Modiselle, M., More, S., Naidoo, M., Scholtz, L., Vangu, M., Aguade-Bruix, S., Blanco, I., Cabrera, A., Camarero, A., Casans-Tormo, I., Cuellar-Calabria, H., Flotats, A., Fuentes Canamero, M.E., Garcia, M.E., Jimenez-Heffernan, A., Leta, R., Diaz, J.L., Lumbreras, L., Marquez-Cabeza, J.J., Martin, F., Martinez de Alegria, A., Medina, F., Canal, M.P., Peiro, V., Pubul-Nunez, V., Rayo Madrid, J.I., Rey, C.R., Perez, R.R., Ruiz, J., Hernandez, G.S., Sevilla, A., Zeidan, N., Nanayakkara, D., Udugama, C., Simonsson, M., Alkadhi, H., Buechel, R.R., Burger, P., Ceriani, L., De Boeck, B., Grani, C., Juillet de Saint Lager Lucas, A., Kamani, C.H., Kawel-Boehm, N., Manka, R., Prior, J.O., Rominger, A., Vallee, J.-., Khiewvan, B., Premprabha, T., Thientunyakit, T., Sellem, A., Kir, K.M., Sayman, H., Sebikali, M.J., Muyinda, Z., Kmetyuk, Y., Korol, P., Mykhalchenko, O., Pliatsek, V., Satyr, M., Albalooshi, B., Ahmed Hassan, M.I., Anderson, J., Bedi, P., Biggans, T., Bularga, A., Bull, R., Burgul, R., Carpenter, J.-., Coles, D., Cusack, D., Deshpande, A., Dougan, J., Fairbairn, T., Farrugia, A., Gopalan, D., Gummow, A., Ramkumar, P.G., Hamilton, M., Harbinson, M., Hartley, T., Hudson, B., Joshi, N., Kay, M., Kelion, A., Khokhar, A., Kitt, J., Low, C., Mak, S.M., Marousa, N., Martin, J., Mcalindon, E., Menezes, L., Morgan-Hughes, G., Moss, A., Murray, A., Nicol, E., Patel, D., Peebles, C., Pugliese, F., Luis Rodrigues, J.C., Rofe, C., Sabharwal, N., Schofield, R., Semple, T., Sharma, N., Strouhal, P., Subedi, D., Topping, W., Tweed, K., Weir-Mccall, J., Abbara, S., Abbasi, T., Abbott, B., Abohashem, S., Abramson, S., Al-Abboud, T., Al-Mallah, M., Almousalli, O., Ananthasubramaniam, K., Kumar, M.A., Askew, J., Attanasio, L., Balmer-Swain, M., Bayer, R.R., Bernheim, A., Bhatti, S., Bieging, E., Blankstein, R., Bloom, S., Blue, S., Bluemke, D., Borges, A., Branch, K., Bravo, P., Brothers, J., Budoff, M., Bullock-Palmer, R., Burandt, A., Burke, F.W., Bush, K., Candela, C., Capasso, E., Cavalcante, J., Chang, D., Chatterjee, S., Chatzizisis, Y., Cheezum, M., Chen, T., Chen, J., Chen, M., Clarcq, J., Cordero, A., Crim, M., Danciu, S., Decter, B., Dhruva, N., Doherty, N., Doukky, R., Dunbar, A., Duvall, W., Edwards, R., Esquitin, K., Farah, H., Fentanes, E., Ferencik, M., Fisher, D., Fitzpatrick, D., Foster, C., Fuisz, T., Gannon, M., Gastner, L., Gerson, M., Ghoshhajra, B., Goldberg, A., Goldner, B., Gonzalez, J., Gore, R., Gracia-Lopez, S., Hage, F., Haider, A., Haider, S., Hamirani, Y., Hassen, K., Hatfield, M., Hawkins, C., Hawthorne, K., Heath, N., Hendel, R., Hernandez, P., Hill, G., Horgan, S., Huffman, J., Hurwitz, L., Iskandrian, A., Janardhanan, R., Jellis, C., Jerome, S., Kalra, D., Kaviratne, S., Kay, F., Kelly, F., Khalique, O., Kinkhabwala, M., Iii, G.K., Kircher, J., Kirkbride, R., Kontos, M., Kottam, A., Krepp, J., Layer, J., Lee, S.H., Leppo, J., Lesser, J., Leung, S., Lewin, H., Litmanovich, D., Liu, Y., Magurany, K., Markowitz, J., Marn, A., Matis, S.E., Mckenna, M., Mcrae, T., Mendoza, F., Merhige, M., Min, D., Moffitt, C., Moncher, K., Moore, W., Morayati, S., Morris, M., Mossa-Basha, M., Mrsic, Z., Murthy, V., Nagpal, P., Napier, K., Nelson, K., Nijjar, P., Osman, M., Passen, E., Patel, A., Patil, P., Paul, R., Phillips, L., Polsani, V., Poludasu, R., Pomerantz, B., Porter, T., Prentice, R., Pursnani, A., Rabbat, M., Ramamurti, S., Rich, F., Luna, H.R., Robinson, A., Robles, K., Rodriguez, C., Rorie, M., Rumberger, J., Russell, R., Sabra, P., Sadler, D., Schemmer, M., Schoepf, U.J., Shah, S., Shah, N., Shanbhag, S., Sharma, G., Shayani, S., Shirani, J., Shivaram, P., Sigman, S., Simon, M., Slim, A., Smith, D., Smith, A., Soman, P., Srichai-Parsia, M.B., Streeter, J., T, A., Tawakol, A., Thomas, D., Thompson, R., Torbet, T., Trinidad, D., Ullery, S., Unzek, S., Uretsky, S., Vallurupalli, S., Verma, V., Waller, A., Wang, E., Ward, P., Weissman, G., Wesbey, G., White, K., Winchester, D., Wolinsky, D., Yost, S., Zgaljardic, M., Alonso, O., Beretta, M., Ferrando, R., Kapitan, M., Mut, F., Djuraev, O., Rozikhodjaeva, G., Le Ngoc, H., Mai, S.H., and Nguyen, X.C.
- Subjects
INCAPS COVID Investigators Group ,Pediatric Research Initiative ,positron emission tomography ,CTA ,SARS-CoV-2 ,cardiac testing ,invasive coronary angiography ,Prevention ,coronavirus ,coronavirus disease-19 ,COVID-19 ,global health ,Settore MED/11 - Malattie dell'Apparato Cardiovascolare ,cardiac magnetic resonance ,cardiovascular disease ,NO ,transthoracic echocardiography ,PET ,Good Health and Well Being ,severe acute respiratory syndrome-coronavirus-2 ,TTE ,ICA ,CMR ,computed tomographic angiography - Abstract
BackgroundThe coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known.ObjectivesThis study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagnostic procedures and safety practices in Asia.MethodsThe International Atomic Energy Agency conducted a worldwide survey to assess changes in cardiovascular procedure volume and safety practices caused by COVID-19. Testing volumes were reported for March 2020 and April 2020 and were compared to those from March 2019. Data from 180 centers across 33 Asian countries were grouped into 4 subregions for comparison.ResultsProcedure volumes decreased by 47% from March 2019 to March 2020, showing recovery from March 2020 to April 2020 in Eastern Asia, particularly in China. The majority of centers cancelled outpatient activities and increased time per study. Practice changes included implementing physical distancing and restricting visitors. Although COVID testing was not commonly performed, it was conducted in one-third of facilities in Eastern Asia. The most severe reductions in procedure volumes were observed in lower-income countries, where volumes decreased 81% from March 2019 to April2020.ConclusionsThe COVID-19 pandemic in Asia caused significant reductions in cardiovascular diagnostic procedures, particularly in low-income countries. Further studies on effects of COVID-19 on cardiovascular outcomes and changes in care delivery are warranted.
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- 2021
13. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia
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Kudo, T, Lahey, R, Hirschfeld, C, Williams, M, Lu, B, Alasnag, M, Bhatia, M, Henry Bom, H, Dautov, T, Fazel, R, Karthikeyan, G, Keng, F, Rubinshtein, R, Better, N, Cerci, R, Dorbala, S, Raggi, P, Shaw, L, Villines, T, Vitola, J, Choi, A, Malkovskiy, E, Goebel, B, Cohen, Y, Randazzo, M, Pascual, T, Pynda, Y, Dondi, M, Paez, D, Einstein, A, Hinterleitner, G, Lu, Y, Morozova, O, Xu, Z, Lopez-Mattei, J, Parwani, P, Nasery, M, Goda, A, Shirka, E, Benlabgaa, R, Bouyoucef, S, Medjahedi, A, Nailli, Q, Agolti, M, Aguero, R, Alak, M, Alberguina, L, Arroñada, G, Astesiano, A, Norton, C, Benteo, P, Blanco, J, Bonelli, J, Bustos, J, Cabrejas, R, Cachero, J, Campisi, R, Canderoli, A, Carames, S, Carrascosa, P, Castro, R, Cendoya, O, Cognigni, L, Collaud, C, Cortes, C, Courtis, J, Cragnolino, D, Daicz, M, De La Vega, A, De Maria, S, Del Riego, H, Dettori, F, Deviggiano, A, Dragonetti, L, Embon, M, Enriquez, R, Ensinas, J, Faccio, F, Facello, A, Garofalo, D, Geronazzo, R, Gonza, N, Gutierrez, L, 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Enriquez, Ruben Emilio, Ensinas, Jorge, Faccio, Fernando, Facello, Adolfo, Garofalo, Diego, Geronazzo, Ricardo, Gonza, Natalia, Gutierrez, Lucas, Guzzo, Miguel Angel, Hasbani, Victor, Huerin, Melina, Jäger, Victor, Lewkowicz, Julio Manuel, López De Munaín, Maria Nieves A., Lotti, Jose Maria, Marquez, Alejandra, Masoli, Osvaldo, Masoli, Osvaldo Horacio, Mastrovito, Edgardo, Mayoraz, Matias, Melado, Graciela Eva, Mele, Anibal, Merani, Maria Fernanda, Meretta, Alejandro Horacio, Molteni, Susana, Montecinos, Marcos, Noguera, Eduardo, Novoa, Carlos, Sueldo, Claudio Pereyra, Ascani, Sebastian Perez, Pollono, Pablo, Pujol, Maria Paula, Radzinschi, Alejandro, Raimondi, Gustavo, Redruello, Marcela, Rodríguez, Marina, Rodríguez, Matías, Romero, Romina Lorena, Acuña, Arturo Romero, Rovaletti, Federico, San Miguel, Lucas, Solari, Lucrecia, Strada, Bruno, Traverso, Sonia, Traverzo, Sonia Simona, Espeche, Maria del Huerto Velazquez, Weihmuller, Juan Sebastian, Wolcan, Juan, Zeffiro, Susana, Sakanyan, Mari, Beuzeville, Scott, Boktor, Raef, Butler, Patrick, Calcott, Jennifer, Carr, Loretta, Chan, Virgil, Chao, Charles, Chong, Woon, Dobson, Mark, Downie, D'Arne, Dwivedi, Girish, Elison, Barry, Engela, Jean, Francis, Roslyn, Gaikwad, Anand, Basavaraj, Ashok Gangasandra, Goodwin, Bruce, Greenough, Robert, Hamilton-Craig, Christian, Hsieh, Victar, Joshi, Subodh, Lederer, Karin, Lee, Kenneth, Lee, Joseph, Magnussen, John, Mai, Nghi, Mander, Gordon, Murton, Fiona, Nandurkar, Dee, Neill, Johanne, O'Rourke, Edward, O'Sullivan, Patricia, Pandos, George, Pathmaraj, Kunthi, Pitman, Alexander, Poulter, Rohan, Premaratne, Manuja, Prior, David, Ridley, Lloyd, Rutherford, Natalie, Salehi, Hamid, Saunders, Connor, Scarlett, Luke, Seneviratne, Sujith, Shetty, Deepa, Shrestha, Ganesh, Shulman, Jonathan, Solanki, Vijay, Stanton, Tony, Stuart, Murch, Stubbs, Michael, Swainson, Ian, Taubman, Kim, Taylor, Andrew, Thomas, Paul, Unger, Steven, Upton, Anthony, Vamadevan, Shankar, Van Gaal, William, Verjans, Johan, Voutnis, Demetrius, Wayne, Victor, Wilson, Peter, Wong, David, Wong, Kirby, Younger, John, Feuchtner, Gudrun, Mirzaei, Siroos, Weiss, Konrad, Maroz-Vadalazhskaya, Natallia, Gheysens, Olivier, Homans, Filip, Moreno-Reyes, Rodrigo, Pasquet, Agnès, Roelants, Veronique, Van De Heyning, Caroline M., Ríos, Raúl Araujo, Soldat-Stankovic, Valentina, Stankovic, Sinisa, Albernaz Siqueira, Maria Helena, Almeida, Augusto, Alves Togni, Paulo Henrique, Andrade, Jose Henrique, Andrade, Luciana, Anselmi, Carlos, Araújo, Roberta, Azevedo, Guilherme, Bezerra, Sabbrina, Biancardi, Rodrigo, Grossman, Gabriel Blacher, Brandão, Simone, Pianta, Diego Bromfman, Carreira, Lara, Castro, Bruno, Chang, Tien, Cunali, Fernando, Cury, Roberto, Dantas, Roberto, de Amorim Fernandes, Fernando, De Lorenzo, Andrea, De Macedo Filho, Robson, Erthal, Fernanda, Fernandes, Fabio, Fernandes, Juliano, De Souza, Thiago Ferreira, Alves, Wilson Furlan, Ghini, Bruno, Goncalves, Luiz, Gottlieb, Ilan, Hadlich, Marcelo, Kameoka, Vinícius, Lima, Ronaldo, Lima, Adna, Lopes, Rafael Willain, Machado e Silva, Ricardo, Magalhães, Tiago, Silva, Fábio Martins, Mastrocola, Luiz Eduardo, Medeiros, Fábio, Meneghetti, José Claudio, Naue, Vania, Naves, Danilo, Nolasco, Roberto, Nomura, Cesar, Oliveira, Joao Bruno, Paixao, Eduardo, De Carvalho, Filipe Penna, Pinto, Ibraim, Possetti, Priscila, Quinta, Mayra, Nogueira Ramos, Rodrigo Rizzo, Rocha, Ricardo, Rodrigues, Alfredo, Rodrigues, Carlos, Romantini, Leila, Sanches, Adelina, Santana, Sara, Sara da Silva, Leonardo, Schvartzman, Paulo, Matushita, Cristina Sebastião, Senra, Tiago, Shiozaki, Afonso, Menezes de Siqueira, Maria Eduarda, Siqueira, Cristiano, Smanio, Paola, Soares, Carlos Eduardo, Junior, José Soares, Bittencourt, Marcio Sommer, Spiro, Bernardo, Mesquita, Cláudio Tinoco, Torreao, Jorge, Torres, Rafael, Uellendahl, Marly, Monte, Guilherme Urpia, Veríssimo, Otávia, Cabeda, Estevan Vieira, Pedras, Felipe Villela, Waltrick, Roberto, Zapparoli, Marcello, Naseer, Hamid, Garcheva-Tsacheva, Marina, Kostadinova, Irena, Theng, Youdaline, Abikhzer, Gad, Barette, Rene, Chow, Benjamin, Dabreo, Dominique, Friedrich, Matthias, Garg, Ria, Hafez, Mohammed Nassoh, Johnson, Chris, Kiess, Marla, Leipsic, Jonathon, Leung, Eugene, Miller, Robert, Oikonomou, Anastasia, Probst, Stephan, Roifman, Idan, Small, Gary, Tandon, Vikas, Trivedi, Adwait, White, James, Zukotynski, Katherine, Canessa, Jose, Muñoz, Gabriel Castro, Concha, Carmen, Hidalgo, Pablo, Lovera, Cesar, Massardo, Teresa, Vargas, Luis Salazar, Abad, Pedro, Arturo, Harold, Ayala, Sandra, Benitez, Luis, Cadena, Alberto, Caicedo, Carlos, Moncayo, Antonio Calderón, Gomez, Sharon, Gutierrez Villamil, Claudia T., Jaimes, Claudia, Londoño, Juan, Londoño Blair, Juan Luis, Pabon, Luz, Pineda, Mauricio, Rojas, Juan Carlos, Ruiz, Diego, Escobar, Manuel Valencia, Vasquez, Andres, Vergel, Damiana, Zuluaga, Alejandro, Gamboa, Isabel Berrocal, Castro, Gabriel, González, Ulises, Baric, Ana, Batinic, Tonci, Franceschi, Maja, Paar, Maja Hrabak, Jukic, Mladen, Medakovic, Petar, Persic, Viktor, Prpic, Marina, Punda, Ante, Batista, Juan Felipe, Gómez Lauchy, Juan Manuel, Gutierrez, Yamile Marcos, Menéndez, Rayner, Peix, Amalia, Rochela, Luis, Panagidis, Christoforos, Petrou, Ioannis, Engelmann, Vaclav, Kaminek, Milan, Kincl, Vladimír, Lang, Otto, Simanek, Milan, Abdulla, Jawdat, Bøttcher, Morten, Christensen, Mette, Gormsen, Lars Christian, Hasbak, Philip, Hess, Søren, Holdgaard, Paw, Johansen, Allan, Kyhl, Kasper, Norgaard, Bjarne Linde, Øvrehus, Kristian Altern, Rønnow Sand, Niels Peter, Steffensen, Rolf, Thomassen, Anders, Zerahn, Bo, Perez, Alfredo, Escorza Velez, Giovanni Alejandro, Velez, Mayra Sanchez, Abdel Aziz, Islam Shawky, Abougabal, Mahasen, Ahmed, Taghreed, Allam, Adel, Asfour, Ahmed, Hassan, Mona, Hassan, Alia, Ibrahim, Ahmed, Kaffas, Sameh, Kandeel, Ahmed, Ali, Mohamed Mandour, Mansy, Ahmad, Maurice, Hany, Nabil, Sherif, Shaaban, Mahmoud, Flores, Ana Camila, Poksi, Anne, Knuuti, Juhani, Kokkonen, Velipekka, Larikka, Martti, Uusitalo, Valtteri, Bailly, Matthieu, Burg, Samuel, Deux, Jean-François, Habouzit, Vincent, Hyafil, Fabien, Lairez, Olivier, Proffit, Franck, Regaieg, Hamza, Sarda-Mantel, Laure, Tacher, Vania, Schneider, Roman P., Ayetey, Harold, Angelidis, George, Archontaki, Aikaterini, Chatziioannou, Sofia, Datseris, Ioannis, Fragkaki, Christina, Georgoulias, Panagiotis, Koukouraki, Sophia, Koutelou, Maria, Kyrozi, Eleni, Repasos, Evangelos, Stavrou, Petros, Valsamaki, Pipitsa, Gonzalez, Carla, Gutierrez, Goleat, Maldonado, Alejandro, Buga, Klara, Garai, Ildiko, Maurovich-Horvat, Pál, Schmidt, Erzsébet, Szilveszter, Balint, Várady, Edit, Banthia, Nilesh, Bhagat, Jinendra Kumar, Bhargava, Rishi, Bhat, Vivek, Choudhury, Partha, Chowdekar, Vijay Sai, Irodi, Aparna, Jain, Shashank, Joseph, Elizabeth, Kumar, Sukriti, Girijanandan Mahapatra, Prof Dr, Mitra, Deepanjan, Mittal, Bhagwant Rai, Ozair, Ahmad, Patel, Chetan, Patel, Tapan, Patel, Ravi, Patel, Shivani, Saxena, Sudhir, Sengupta, Shantanu, Singh, Santosh, Singh, Bhanupriya, Sood, Ashwani, Verma, Atul, Affandi, Erwin, Alam, Padma Savenadia, Edison, Edison, Gunawan, Gani, Hapkido, Habusari, Hidayat, Basuki, Huda, Aulia, Mukti, Anggoro Praja, Prawiro, Djoko, Soeriadi, Erwin Affandi, Syawaluddin, Hilman, Albadr, Amjed, Assadi, Majid, Emami, Farshad, Houshmand, Golnaz, Maleki, Majid, Rostami, Maryam Tajik, Zakavi, Seyed Rasoul, Zaid, Eed Abu, Agranovich, Svetlana, Arnson, Yoav, Bar-Shalom, Rachel, Frenkel, Alex, Knafo, Galit, Lugassi, Rachel, Maor Moalem, Israel Shlomo, Mor, Maya, Muskal, Noam, Ranser, Sara, Shalev, Aryeh, Albano, Domenico, Alongi, Pierpaolo, Arnone, Gaspare, Bagatin, Elisa, Baldari, Sergio, Bauckneht, Matteo, Bertelli, Paolo, Bianco, Francesco, Bonfiglioli, Rachele, Boni, Roberto, Bruno, Andrea, Bruno, Isabella, Busnardo, Elena, Califaretti, Elena, Camoni, Luca, Carnevale, Aldo, Casoni, Roberta, Cavallo, Armando Ugo, Cavenaghi, Giorgio, Chierichetti, Franca, Chiocchi, Marcello, Cittanti, Corrado, Colletta, Mauro, Conti, Umberto, Cossu, Alberto, Cuocolo, Alberto, Cuzzocrea, Marco, De Rimini, Maria Luisa, De Vincentis, Giuseppe, Del Giudice, Eleonora, Del Torto, Alberico, Della Tommasina, Veronica, Durmo, Rexhep, Erba, Paola Anna, Evangelista, Laura, Faletti, Riccardo, Faragasso, Evelina, Farsad, Mohsen, Ferro, Paola, Florimonte, Luigia, Frantellizzi, Viviana, Fringuelli, Fabio Massimo, Gatti, Marco, Gaudiano, Angela, Gimelli, Alessia, Giubbini, Raffaele, Giuffrida, Francesca, Ialuna, Salvatore, Laudicella, Riccardo, Leccisotti, Lucia, Leva, Lucia, Liga, Riccardo, Liguori, Carlo, Longo, Giampiero, Maffione, Margherita, Mancini, Maria Elisabetta, Marcassa, Claudio, Milan, Elisa, Nardi, Barbara, Pacella, Sara, Pepe, Giovanna, Pontone, Gianluca, Pulizzi, Sabina, Quartuccio, Natale, Rampin, Lucia, Ricci, Fabrizio, Rossini, Pierluigi, Rubini, Giuseppe, Russo, Vincenzo, Sacchetti, Gian Mauro, Sambuceti, Gianmario, Scarano, Massimo, Sciagrà, Roberto, Sperandio, Massimiliano, Stefanelli, Antonella, Ventroni, Guido, Zoboli, Stefania, Baugh, Dainia, Chambers, Duane, Madu, Ernest, Nunura, Felix, Asano, Hiroshi, Chimura, Chimura Misato, Fujimoto, Shinichiro, Fujisue, Koichiro, Fukunaga, Tomohisa, Fukushima, Yoshimitsu, Fukuyama, Kae, Hashimoto, Jun, Ichikawa, Yasutaka, Iguchi, Nobuo, Imai, Masamichi, Inaki, Anri, Ishimura, Hayato, Isobe, Satoshi, Kadokami, Toshiaki, Kato, Takao, Kumita, Shinichiro, Maruno, Hirotaka, Mataki, Hiroyuki, Miyagawa, Masao, Morimoto, Ryota, Moroi, Masao, Nagamachi, Shigeki, Nakajima, Kenichi, Nakata, Tomoaki, Nakazato, Ryo, Nanasato, Mamoru, Naya, Masanao, Norikane, Takashi, Ohta, Yasutoshi, Okayama, Satoshi, Okizaki, Atsutaka, Otomi, Yoichi, Otsuka, Hideki, Saito, Masaki, Sakata, Sakata Yasushi, Sarai, Masayoshi, Sato, Daisuke, Shiraishi, Shinya, Suwa, Yoshinobu, Takanami, Kentaro, Takehana, Kazuya, Taki, Junichi, Tamaki, Nagara, Taniguchi, Yasuyo, Teragawa, Hiroki, Tomizawa, Nobuo, Tsujita, Kenichi, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Batyrkhanov, Daultai, Makhdomi, Khalid, Ombati, Kevin, Alkandari, Faridah, Garashi, Masoud, Coie, Tchoyoson Lim, Rajvong, Sonexay, Kalinin, Artem, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Mataciunas, Mindaugas, Vajauskas, Donatas, Picard, Christian, Karim, Noor Khairiah A., Reichmuth, Luise, Samuel, Anthony, Allarakha, Mohammad Aaftaab, Naojee, Ambedhkar Shantaram, Alexanderson-Rosas, Erick, Barragan, Erika, González-Montecinos, Alejandro Becerril, Cabada, Manuel, Rodriguez, Daniel Calderon, Carvajal-Juarez, Isabel, Cortés, Violeta, Cortés, Filiberto, De La Peña, Erasmo, Gama-Moreno, Manlio, González, Luis, Ramírez, Nelsy Gonzalez, Jiménez-Santos, Moisés, Matos, Luis, Monroy, Edgar, Morelos, Martha, Ornelas, Mario, Ortga Ramirez, Jose Alberto, Preciado-Anaya, Andrés, Preciado-Gutiérrez, Óscar Ulises, Barragan, Adriana Puente, Rosales Uvera, Sandra Graciela, Sandoval, Sigelinda, Tomas, Miguel Santaularia, Sierra-Galan, Lilia M., Siu, Silvia, Vallejo, Enrique, Valles, Mario, Faraggi, Marc, Sereegotov, Erdenechimeg, Ilic, Srdja, Ben-Rais, Nozha, Alaoui, Nadia Ismaili, Taleb, Sara, Pa Myo, Khin Pa, Thu, Phyo Si, Ghimire, Ram Kumar, Rajbanshi, Bijoy, Barneveld, Peter, Glaudemans, Andor, Habets, Jesse, Koopmans, Klaas Pieter, Manders, Jeroen, Pool, Stefan, Scholte, Arthur, Scholtens, Asbjørn, Slart, Riemer, Thimister, Paul, Van Asperen, Erik-Jan, Veltman, Niels, Verschure, Derk, Wagenaar, Nils, Edmond, John, Ellis, Chris, Johnson, Kerryanne, Keenan, Ross, Kueh, Shaw Hua (Anthony), Occleshaw, Christopher, Sasse, Alexander, To, Andrew, Van Pelt, Niels, Young, Calum, Cuadra, Teresa, Roque Vanegas, Hector Bladimir, Soli, Idrissa Adamou, Issoufou, Djibrillou Moussa, Ayodele, Tolulope, Madu, Chibuzo, Onimode, Yetunde, Efros-Monsen, Elen, Forsdahl, Signe Helene, Hildre Dimmen, Jenni-Mari, Jørgensen, Arve, Krohn, Isabel, Løvhaugen, Pål, Bråten, Anders Tjellaug, Al Dhuhli, Humoud, Al Kindi, Faiza, Al-Bulushi, Naeema, Jawa, Zabah, Tag, Naima, Afzal, Muhammad Shehzad, Fatima, Shazia, Younis, Muhammad Numair, Riaz, Musab, Saadullah, Mohammad, Herrera, Yariela, Lenturut-Katal, Dora, Vázquez, Manuel Castillo, Ortellado, José, Akhter, Afroza, Cao, Dianbo, Cheung, Stephen, Dai, Xu, Gong, Lianggeng, Han, Dan, Hou, Yang, Li, Caiying, Li, Tao, Li, Dong, Li, Sijin, Liu, Jinkang, Liu, Hui, Ng, Ming Yen, Sun, Kai, Tang, Gongshun, Wang, Jian, Wang, Ximing, Wang, Zhao-Qian, Wang, Yining, Wang, Yifan, Wu, Jiang, Wu, Zhifang, Xia, Liming, Xiao, Jiangxi, Xu, Lei, Yang, Youyou, Yin, Wu, Yu, Jianqun, Yuan, Li, Zhang, Tong, Zhang, Longjiang, Zhang, Yong-Gao, Zhang, Xiaoli, Zhu, Li, Alfaro, Ana, Abrihan, Paz, Barroso, Asela, Cruz, Eric, Gomez, Marie Rhiamar, Magboo, Vincent Peter, Medina, John Michael, Obaldo, Jerry, Pastrana, Davidson, Pawhay, Christian Michael, Quinon, Alvin, Tang, Jeanelle Margareth, Tecson, Bettina, Uson, Kristine Joy, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Bettencourt, Nuno, Cantinho, Guilhermina, Ferreira, Antonio, Syed, Ghulam, Arnous, Samer, Atyani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, Meehan, Conor, Murphy, David, Murphy, Mark, Murray, John, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cho, Sang-Geon, Hong, Chae Moon, Jang, Su Jin, Jeong, Yong Hyu, Kang, Won Jun, Kim, Ji-Young, Lee, Jaetae, Namgung, Chang Kyeong, So, Young, Won, Kyoung Sook, Majstorov, Venjamin, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Benedek, Imre, Mititelu, Raluca, Stan, Claudiu Adrian, Ansheles, Alexey, Dariy, Olga, Drozdova, Olga, Gagarina, Nina, Gulyaev, Vsevolod Milyevich, Itskovich, Irina, Karalkin, Anatoly, Kokov, Alexander, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Saifullina, Guzaliya, Sazonova, Svetlana, Sergienko, Vladimir, Shurupova, Irina, Trifonova, Tatjana, Ussov, Wladimir Yurievich, Vakhromeeva, Margarita, Valiullina, Nailya, Zavadovsky, Konstantin, Zhuravlev, Kirill, Okarvi, Subhani, Saranovic, Dragana Sobic, Keng, Felix, Jason See, Jia Hao, Sekar, Ramkumar, Yew, Min Sen, Vondrak, Andrej, Bejai, Shereen, Bennie, George, Bester, Ria, Engelbrecht, Gerrit, Evbuomwan, Osayande, Gongxeka, Harlem, Vuuren, Magritha Jv, Kaplan, Mitchell, Khushica, Purbhoo, Lakhi, Hoosen, Louw, Lizette, Malan, Nico, Milos, Katarina, Modiselle, Moshe, More, Stuart, Naidoo, Mathava, Scholtz, Leonie, Vangu, Mboyo, Aguadé-Bruix, Santiago, Blanco, Isabel, Cabrera, Antonio, Camarero, Alicia, Casáns-Tormo, Irene, Cuellar-Calabria, Hug, Flotats, Albert, Fuentes Cañamero, Maria Eugenia, García, María Elia, Jimenez-Heffernan, Amelia, Leta, Rubén, Diaz, Javier Lopez, Lumbreras, Luis, Marquez-Cabeza, Juan Javier, Martin, Francisco, Martinez de Alegria, Anxo, Medina, Francisco, Canal, Maria Pedrera, Peiro, Virginia, Pubul-Nuñez, Virginia, Rayo Madrid, Juan Ignacio, Rey, Cristina Rodríguez, Perez, Ricardo Ruano, Ruiz, Joaquín, Hernández, Gertrudis Sabatel, Sevilla, Ana, Zeidán, Nahla, Nanayakkara, Damayanthi, Udugama, Chandraguptha, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Ceriani, Luca, De Boeck, Bart, Gräni, Christoph, Juillet de Saint Lager Lucas, Alix, Kamani, Christel H., Kawel-Boehm, Nadine, Manka, Robert, Prior, John O., Rominger, Axel, Vallée, Jean-Paul, Khiewvan, Benjapa, Premprabha, Teerapon, Thientunyakit, Tanyaluck, Sellem, Ali, Kir, Kemal Metin, Sayman, Haluk, Sebikali, Mugisha Julius, Muyinda, Zerida, Kmetyuk, Yaroslav, Korol, Pavlo, Mykhalchenko, Olena, Pliatsek, Volodymyr, Satyr, Maryna, Albalooshi, Batool, Ahmed Hassan, Mohamed Ismail, Anderson, Jill, Bedi, Punit, Biggans, Thomas, Bularga, Anda, Bull, Russell, Burgul, Rajesh, Carpenter, John-Paul, Coles, Duncan, Cusack, David, Deshpande, Aparna, Dougan, John, Fairbairn, Timothy, Farrugia, Alexia, Gopalan, Deepa, Gummow, Alistair, Ramkumar, Prasad Guntur, Hamilton, Mark, Harbinson, Mark, Hartley, Thomas, Hudson, Benjamin, Joshi, Nikhil, Kay, Michael, Kelion, Andrew, Khokhar, Azhar, Kitt, Jamie, Lee, Ken, Low, Chen, Mak, Sze Mun, Marousa, Ntouskou, Martin, Jon, Mcalindon, Elisa, Menezes, Leon, Morgan-Hughes, Gareth, Moss, Alastair, Murray, Anthony, Nicol, Edward, Patel, Dilip, Peebles, Charles, Pugliese, Francesca, Luis Rodrigues, Jonathan Carl, Rofe, Christopher, Sabharwal, Nikant, Schofield, Rebecca, Semple, Thomas, Sharma, Naveen, Strouhal, Peter, Subedi, Deepak, Topping, William, Tweed, Katharine, Weir-Mccall, Jonathan, Abbara, Suhny, Abbasi, Taimur, Abbott, Brian, Abohashem, Shady, Abramson, Sandra, Al-Abboud, Tarek, Al-Mallah, Mouaz, Almousalli, Omar, Ananthasubramaniam, Karthikeyan, Kumar, Mohan Ashok, Askew, Jeffrey, Attanasio, Lea, Balmer-Swain, Mallory, Bayer, Richard R., Bernheim, Adam, Bhatti, Sabha, Bieging, Erik, Blankstein, Ron, Bloom, Stephen, Blue, Sean, Bluemke, David, Borges, Andressa, Branch, Kelley, Bravo, Paco, Brothers, Jessica, Budoff, Matthew, Bullock-Palmer, Renée, Burandt, Angela, Burke, Floyd W., Bush, Kelvin, Candela, Candace, Capasso, Elizabeth, Cavalcante, Joao, Chang, Donald, Chatterjee, Saurav, Chatzizisis, Yiannis, Cheezum, Michael, Chen, Tiffany, Chen, Jennifer, Chen, Marcus, Clarcq, James, Cordero, Ayreen, Crim, Matthew, Danciu, Sorin, Decter, Bruce, Dhruva, Nimish, Doherty, Neil, Doukky, Rami, Dunbar, Anjori, Duvall, William, Edwards, Rachael, Esquitin, Kerry, Farah, Husam, Fentanes, Emilio, Ferencik, Maros, Fisher, Daniel, Fitzpatrick, Daniel, Foster, Cameron, Fuisz, Tony, Gannon, Michael, Gastner, Lori, Gerson, Myron, Ghoshhajra, Brian, Goldberg, Alan, Goldner, Brian, Gonzalez, Jorge, Gore, Rosco, Gracia-López, Sandra, Hage, Fadi, Haider, Agha, Haider, Sofia, Hamirani, Yasmin, Hassen, Karen, Hatfield, Mallory, Hawkins, Carolyn, Hawthorne, Katie, Heath, Nicholas, Hendel, Robert, Hernandez, Phillip, Hill, Gregory, Horgan, Stephen, Huffman, Jeff, Hurwitz, Lynne, Iskandrian, Ami, Janardhanan, Rajesh, Jellis, Christine, Jerome, Scott, Kalra, Dinesh, Kaviratne, Summanther, Kay, Fernando, Kelly, Faith, Khalique, Omar, Kinkhabwala, Mona, Iii, George Kinzfogl, Kircher, Jacqueline, Kirkbride, Rachael, Kontos, Michael, Kottam, Anupama, Krepp, Joseph, Layer, Jay, Lee, Steven H., Leppo, Jeffrey, Lesser, John, Leung, Steve, Lewin, Howard, Litmanovich, Diana, Liu, Yiyan, Magurany, Kathleen, Markowitz, Jeremy, Marn, Amanda, Matis, Stephen E., Mckenna, Michael, Mcrae, Tony, Mendoza, Fernando, Merhige, Michael, Min, David, Moffitt, Chanan, Moncher, Karen, Moore, Warren, Morayati, Shamil, Morris, Michael, Mossa-Basha, Mahmud, Mrsic, Zorana, Murthy, Venkatesh, Nagpal, Prashant, Napier, Kyle, Nelson, Katarina, Nijjar, Prabhjot, Osman, Medhat, Passen, Edward, Patel, Amit, Patil, Pravin, Paul, Ryan, Phillips, Lawrence, Polsani, Venkateshwar, Poludasu, Rajaram, Pomerantz, Brian, Porter, Thomas, Prentice, Ryan, Pursnani, Amit, Rabbat, Mark, Ramamurti, Suresh, Rich, Florence, Luna, Hiram Rivera, Robinson, Austin, Robles, Kim, Rodríguez, Cesar, Rorie, Mark, Rumberger, John, Russell, Raymond, Sabra, Philip, Sadler, Diego, Schemmer, Mary, Schoepf, U. 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Sakanyan, Mari, Beuzeville, Scott, Boktor, Raef, Butler, Patrick, Calcott, Jennifer, Carr, Loretta, Chan, Virgil, Chao, Charles, Chong, Woon, Dobson, Mark, Downie, D'Arne, Dwivedi, Girish, Elison, Barry, Engela, Jean, Francis, Roslyn, Gaikwad, Anand, Basavaraj, Ashok Gangasandra, Goodwin, Bruce, Greenough, Robert, Hamilton-Craig, Christian, Hsieh, Victar, Joshi, Subodh, Lederer, Karin, Lee, Kenneth, Lee, Joseph, Magnussen, John, Mai, Nghi, Mander, Gordon, Murton, Fiona, Nandurkar, Dee, Neill, Johanne, O'Rourke, Edward, O'Sullivan, Patricia, Pandos, George, Pathmaraj, Kunthi, Pitman, Alexander, Poulter, Rohan, Premaratne, Manuja, Prior, David, Ridley, Lloyd, Rutherford, Natalie, Salehi, Hamid, Saunders, Connor, Scarlett, Luke, Seneviratne, Sujith, Shetty, Deepa, Shrestha, Ganesh, Shulman, Jonathan, Solanki, Vijay, Stanton, Tony, Stuart, Murch, Stubbs, Michael, Swainson, Ian, Taubman, Kim, Taylor, Andrew, Thomas, Paul, Unger, Steven, Upton, Anthony, Vamadevan, Shankar, Van Gaal, William, 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Marcelo, Kameoka, Vinícius, Lima, Ronaldo, Lima, Adna, Lopes, Rafael Willain, Machado e Silva, Ricardo, Magalhães, Tiago, Silva, Fábio Martins, Mastrocola, Luiz Eduardo, Medeiros, Fábio, Meneghetti, José Claudio, Naue, Vania, Naves, Danilo, Nolasco, Roberto, Nomura, Cesar, Oliveira, Joao Bruno, Paixao, Eduardo, De Carvalho, Filipe Penna, Pinto, Ibraim, Possetti, Priscila, Quinta, Mayra, Nogueira Ramos, Rodrigo Rizzo, Rocha, Ricardo, Rodrigues, Alfredo, Rodrigues, Carlos, Romantini, Leila, Sanches, Adelina, Santana, Sara, Sara da Silva, Leonardo, Schvartzman, Paulo, Matushita, Cristina Sebastião, Senra, Tiago, Shiozaki, Afonso, Menezes de Siqueira, Maria Eduarda, Siqueira, Cristiano, Smanio, Paola, Soares, Carlos Eduardo, Junior, José Soares, Bittencourt, Marcio Sommer, Spiro, Bernardo, Mesquita, Cláudio Tinoco, Torreao, Jorge, Torres, Rafael, Uellendahl, Marly, Monte, Guilherme Urpia, Veríssimo, Otávia, Cabeda, Estevan Vieira, Pedras, Felipe Villela, Waltrick, Roberto, Zapparoli, 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Kenichi, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Batyrkhanov, Daultai, Makhdomi, Khalid, Ombati, Kevin, Alkandari, Faridah, Garashi, Masoud, Coie, Tchoyoson Lim, Rajvong, Sonexay, Kalinin, Artem, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Mataciunas, Mindaugas, Vajauskas, Donatas, Picard, Christian, Karim, Noor Khairiah A., Reichmuth, Luise, Samuel, Anthony, Allarakha, Mohammad Aaftaab, Naojee, Ambedhkar Shantaram, Alexanderson-Rosas, Erick, Barragan, Erika, González-Montecinos, Alejandro Becerril, Cabada, Manuel, Rodriguez, Daniel Calderon, Carvajal-Juarez, Isabel, Cortés, Violeta, Cortés, Filiberto, De La Peña, Erasmo, Gama-Moreno, Manlio, González, Luis, Ramírez, Nelsy Gonzalez, Jiménez-Santos, Moisés, Matos, Luis, Monroy, Edgar, Morelos, Martha, Ornelas, Mario, Ortga Ramirez, Jose Alberto, Preciado-Anaya, Andrés, Preciado-Gutiérrez, Óscar Ulises, Barragan, Adriana Puente, Rosales Uvera, Sandra Graciela, Sandoval, Sigelinda, Tomas, Miguel Santaularia, Sierra-Galan, Lilia M., Siu, Silvia, Vallejo, Enrique, Valles, Mario, Faraggi, Marc, Sereegotov, Erdenechimeg, Ilic, Srdja, Ben-Rais, Nozha, Alaoui, Nadia Ismaili, Taleb, Sara, Pa Myo, Khin Pa, Thu, Phyo Si, Ghimire, Ram Kumar, Rajbanshi, Bijoy, Barneveld, Peter, Glaudemans, Andor, Habets, Jesse, Koopmans, Klaas Pieter, Manders, Jeroen, Pool, Stefan, Scholte, Arthur, Scholtens, Asbjørn, Slart, Riemer, Thimister, Paul, Van Asperen, Erik-Jan, Veltman, Niels, Verschure, Derk, Wagenaar, Nils, Edmond, John, Ellis, Chris, Johnson, Kerryanne, Keenan, Ross, Kueh, Shaw Hua (Anthony), Occleshaw, Christopher, Sasse, Alexander, To, Andrew, Van Pelt, Niels, Young, Calum, Cuadra, Teresa, Roque Vanegas, Hector Bladimir, Soli, Idrissa Adamou, Issoufou, Djibrillou Moussa, Ayodele, Tolulope, Madu, Chibuzo, Onimode, Yetunde, Efros-Monsen, Elen, Forsdahl, Signe Helene, Hildre Dimmen, Jenni-Mari, Jørgensen, Arve, Krohn, Isabel, Løvhaugen, Pål, Bråten, Anders Tjellaug, Al Dhuhli, Humoud, Al Kindi, Faiza, Al-Bulushi, Naeema, Jawa, Zabah, Tag, Naima, Afzal, Muhammad Shehzad, Fatima, Shazia, Younis, Muhammad Numair, Riaz, Musab, Saadullah, Mohammad, Herrera, Yariela, Lenturut-Katal, Dora, Vázquez, Manuel Castillo, Ortellado, José, Akhter, Afroza, Cao, Dianbo, Cheung, Stephen, Dai, Xu, Gong, Lianggeng, Han, Dan, Hou, Yang, Li, Caiying, Li, Tao, Li, Dong, Li, Sijin, Liu, Jinkang, Liu, Hui, Ng, Ming Yen, Sun, Kai, Tang, Gongshun, Wang, Jian, Wang, Ximing, Wang, Zhao-Qian, Wang, Yining, Wang, Yifan, Wu, Jiang, Wu, Zhifang, Xia, Liming, Xiao, Jiangxi, Xu, Lei, Yang, Youyou, Yin, Wu, Yu, Jianqun, Yuan, Li, Zhang, Tong, Zhang, Longjiang, Zhang, Yong-Gao, Zhang, Xiaoli, Zhu, Li, Alfaro, Ana, Abrihan, Paz, Barroso, Asela, Cruz, Eric, Gomez, Marie Rhiamar, Magboo, Vincent Peter, Medina, John Michael, Obaldo, Jerry, Pastrana, Davidson, Pawhay, Christian Michael, Quinon, Alvin, Tang, Jeanelle Margareth, Tecson, Bettina, Uson, Kristine Joy, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Bettencourt, Nuno, Cantinho, Guilhermina, Ferreira, Antonio, Syed, Ghulam, Arnous, Samer, Atyani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, Meehan, Conor, Murphy, David, Murphy, Mark, Murray, John, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cho, Sang-Geon, Hong, Chae Moon, Jang, Su Jin, Jeong, Yong Hyu, Kang, Won Jun, Kim, Ji-Young, Lee, Jaetae, Namgung, Chang Kyeong, So, Young, Won, Kyoung Sook, Majstorov, Venjamin, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Benedek, Imre, Mititelu, Raluca, Stan, Claudiu Adrian, Ansheles, Alexey, Dariy, Olga, Drozdova, Olga, Gagarina, Nina, Gulyaev, Vsevolod Milyevich, Itskovich, Irina, Karalkin, Anatoly, Kokov, Alexander, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Saifullina, Guzaliya, Sazonova, Svetlana, Sergienko, Vladimir, Shurupova, Irina, Trifonova, Tatjana, Ussov, Wladimir Yurievich, Vakhromeeva, Margarita, Valiullina, Nailya, Zavadovsky, Konstantin, Zhuravlev, Kirill, Okarvi, Subhani, Saranovic, Dragana Sobic, Keng, Felix, Jason See, Jia Hao, Sekar, Ramkumar, Yew, Min Sen, Vondrak, Andrej, Bejai, Shereen, Bennie, George, Bester, Ria, Engelbrecht, Gerrit, Evbuomwan, Osayande, Gongxeka, Harlem, Vuuren, Magritha Jv, Kaplan, Mitchell, Khushica, Purbhoo, Lakhi, Hoosen, Louw, Lizette, Malan, Nico, Milos, Katarina, Modiselle, Moshe, More, Stuart, Naidoo, Mathava, Scholtz, Leonie, Vangu, Mboyo, Aguadé-Bruix, Santiago, Blanco, Isabel, Cabrera, Antonio, Camarero, Alicia, Casáns-Tormo, Irene, Cuellar-Calabria, Hug, Flotats, Albert, Fuentes Cañamero, Maria Eugenia, García, María Elia, Jimenez-Heffernan, Amelia, Leta, Rubén, Diaz, Javier Lopez, Lumbreras, Luis, Marquez-Cabeza, Juan Javier, Martin, Francisco, Martinez de Alegria, Anxo, Medina, Francisco, Canal, Maria Pedrera, Peiro, Virginia, Pubul-Nuñez, Virginia, Rayo Madrid, Juan Ignacio, Rey, Cristina Rodríguez, Perez, Ricardo Ruano, Ruiz, Joaquín, Hernández, Gertrudis Sabatel, Sevilla, Ana, Zeidán, Nahla, Nanayakkara, Damayanthi, Udugama, Chandraguptha, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Ceriani, Luca, De Boeck, Bart, Gräni, Christoph, Juillet de Saint Lager Lucas, Alix, Kamani, Christel H., Kawel-Boehm, Nadine, Manka, Robert, Prior, John O., Rominger, Axel, Vallée, Jean-Paul, Khiewvan, Benjapa, Premprabha, Teerapon, Thientunyakit, Tanyaluck, Sellem, Ali, Kir, Kemal Metin, Sayman, Haluk, Sebikali, Mugisha Julius, Muyinda, Zerida, Kmetyuk, Yaroslav, Korol, Pavlo, Mykhalchenko, Olena, Pliatsek, Volodymyr, Satyr, Maryna, Albalooshi, Batool, Ahmed Hassan, Mohamed Ismail, Anderson, Jill, Bedi, Punit, Biggans, Thomas, Bularga, Anda, Bull, Russell, Burgul, Rajesh, Carpenter, John-Paul, Coles, Duncan, Cusack, David, Deshpande, Aparna, Dougan, John, Fairbairn, Timothy, Farrugia, Alexia, Gopalan, Deepa, Gummow, Alistair, Ramkumar, Prasad Guntur, Hamilton, Mark, Harbinson, Mark, Hartley, Thomas, Hudson, Benjamin, Joshi, Nikhil, Kay, Michael, Kelion, Andrew, Khokhar, Azhar, Kitt, Jamie, Lee, Ken, Low, Chen, Mak, Sze Mun, Marousa, Ntouskou, Martin, Jon, Mcalindon, Elisa, Menezes, Leon, Morgan-Hughes, Gareth, Moss, Alastair, Murray, Anthony, Nicol, Edward, Patel, Dilip, Peebles, Charles, Pugliese, Francesca, Luis Rodrigues, Jonathan Carl, Rofe, Christopher, Sabharwal, Nikant, Schofield, Rebecca, Semple, Thomas, Sharma, Naveen, Strouhal, Peter, Subedi, Deepak, Topping, William, Tweed, Katharine, Weir-Mccall, Jonathan, Abbara, Suhny, Abbasi, Taimur, Abbott, Brian, Abohashem, Shady, Abramson, Sandra, Al-Abboud, Tarek, Al-Mallah, Mouaz, Almousalli, Omar, Ananthasubramaniam, Karthikeyan, Kumar, Mohan Ashok, Askew, Jeffrey, Attanasio, Lea, Balmer-Swain, Mallory, Bayer, Richard R., Bernheim, Adam, Bhatti, Sabha, Bieging, Erik, Blankstein, Ron, Bloom, Stephen, Blue, Sean, Bluemke, David, Borges, Andressa, Branch, Kelley, Bravo, Paco, Brothers, Jessica, Budoff, Matthew, Bullock-Palmer, Renée, Burandt, Angela, Burke, Floyd W., Bush, Kelvin, Candela, Candace, Capasso, Elizabeth, Cavalcante, Joao, Chang, Donald, Chatterjee, Saurav, Chatzizisis, Yiannis, Cheezum, Michael, Chen, Tiffany, Chen, Jennifer, Chen, Marcus, Clarcq, James, Cordero, Ayreen, Crim, Matthew, Danciu, Sorin, Decter, Bruce, Dhruva, Nimish, Doherty, Neil, Doukky, Rami, Dunbar, Anjori, Duvall, William, Edwards, Rachael, Esquitin, Kerry, Farah, Husam, Fentanes, Emilio, Ferencik, Maros, Fisher, Daniel, Fitzpatrick, Daniel, Foster, Cameron, Fuisz, Tony, Gannon, Michael, Gastner, Lori, Gerson, Myron, Ghoshhajra, Brian, Goldberg, Alan, Goldner, Brian, Gonzalez, Jorge, Gore, Rosco, Gracia-López, Sandra, Hage, Fadi, Haider, Agha, Haider, Sofia, Hamirani, Yasmin, Hassen, Karen, Hatfield, Mallory, Hawkins, Carolyn, Hawthorne, Katie, Heath, Nicholas, Hendel, Robert, Hernandez, Phillip, Hill, Gregory, Horgan, Stephen, Huffman, Jeff, Hurwitz, Lynne, Iskandrian, Ami, Janardhanan, Rajesh, Jellis, Christine, Jerome, 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- Abstract
Background: The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known. Objectives: This study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagnostic procedures and safety practices in Asia. Methods: The International Atomic Energy Agency conducted a worldwide survey to assess changes in cardiovascular procedure volume and safety practices caused by COVID-19. Testing volumes were reported for March 2020 and April 2020 and were compared to those from March 2019. Data from 180 centers across 33 Asian countries were grouped into 4 subregions for comparison. Results: Procedure volumes decreased by 47% from March 2019 to March 2020, showing recovery from March 2020 to April 2020 in Eastern Asia, particularly in China. The majority of centers cancelled outpatient activities and increased time per study. Practice changes included implementing physical distancing and restricting visitors. Although COVID testing was not commonly performed, it was conducted in one-third of facilities in Eastern Asia. The most severe reductions in procedure volumes were observed in lower-income countries, where volumes decreased 81% from March 2019 to April 2020. Conclusions: The COVID-19 pandemic in Asia caused significant reductions in cardiovascular diagnostic procedures, particularly in low-income countries. Further studies on effects of COVID-19 on cardiovascular outcomes and changes in care delivery are warranted.
- Published
- 2021
14. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study
- Author
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Albano, D., Bertagna, F., Alongi, P., Baldari, S., Baldoncini, A., Bartolomei, M., Boccaletto, F., Boero, M., Borsatti, E., Bruno, A., Burroni, L., Capoccetti, F., Castellani, M., Cervino, A. R., Chierichetti, Franca, Ciarmiello, A., Corso, A., Cuocolo, A., De Rimini, M. L., Deandreis, D., Dottorini, M. E., Esposito, Francesca, Farsad, Mohsen, Gasparini, M., Grana, C. M., Gregianin, M., Guerra, L., Loreti, F., Lupi, Alessandro, Martino, G., Milan, E., Modoni, S., Morbelli, S., Muni, A., Nicolai, E., Palumbo, B., Papa, S., Papaleo, A., Pellerito, R., Poti, C., Romano, P., Rossetti, Chiara, Rossini, Paolo Maria, Rubini, G., Ruffini, L., Sacchetti, G., Savelli, Giordano, Schiavariello, Saverio, Sciagra, R., Sciuto, R., Seregni, E., Sestini, S., Sicolo, M., Spanu, A., Storto, G., Balducci, M. T., Trifiro, G., Versari, A., Vignati, A., Volterrani, D., Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, A., Evangelista, L., Maroldi, R., Schillaci, O., Giubbini, R., Bonacina, M., Laudicella, R., Spallino, M., Palucci, A., Cuzzocrea, M., Donner, M., Maurea, S., Ceci, F., Dei Rossi, F., Tranfaglia, B., Sartorello, A., Gandolfo, P., Buschiazzo, A., Scarale, A., Kirienko, M., Merenda, N., Nappi, A. G., Durmo, R., Vellani, C., Ceriani, V., Chierichetti F., Esposito F., Farsad M., Lupi A., Rossetti C., Rossini P. (ORCID:0000-0003-2665-534X), Savelli G., Schiavariello S., Calcagni M. L. (ORCID:0000-0002-0805-8245), Marzola M. C., Albano, D., Bertagna, F., Alongi, P., Baldari, S., Baldoncini, A., Bartolomei, M., Boccaletto, F., Boero, M., Borsatti, E., Bruno, A., Burroni, L., Capoccetti, F., Castellani, M., Cervino, A. R., Chierichetti, Franca, Ciarmiello, A., Corso, A., Cuocolo, A., De Rimini, M. L., Deandreis, D., Dottorini, M. E., Esposito, Francesca, Farsad, Mohsen, Gasparini, M., Grana, C. M., Gregianin, M., Guerra, L., Loreti, F., Lupi, Alessandro, Martino, G., Milan, E., Modoni, S., Morbelli, S., Muni, A., Nicolai, E., Palumbo, B., Papa, S., Papaleo, A., Pellerito, R., Poti, C., Romano, P., Rossetti, Chiara, Rossini, Paolo Maria, Rubini, G., Ruffini, L., Sacchetti, G., Savelli, Giordano, Schiavariello, Saverio, Sciagra, R., Sciuto, R., Seregni, E., Sestini, S., Sicolo, M., Spanu, A., Storto, G., Balducci, M. T., Trifiro, G., Versari, A., Vignati, A., Volterrani, D., Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, A., Evangelista, L., Maroldi, R., Schillaci, O., Giubbini, R., Bonacina, M., Laudicella, R., Spallino, M., Palucci, A., Cuzzocrea, M., Donner, M., Maurea, S., Ceci, F., Dei Rossi, F., Tranfaglia, B., Sartorello, A., Gandolfo, P., Buschiazzo, A., Scarale, A., Kirienko, M., Merenda, N., Nappi, A. G., Durmo, R., Vellani, C., Ceriani, V., Chierichetti F., Esposito F., Farsad M., Lupi A., Rossetti C., Rossini P. (ORCID:0000-0003-2665-534X), Savelli G., Schiavariello S., Calcagni M. L. (ORCID:0000-0002-0805-8245), and Marzola M. C.
- Abstract
Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.
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- 2021
15. Paraganglioma no funcionante detectado incidentalmente en la 18F-FDG PET/TC y confirmado mediante gammagrafía con 123I-MIBG
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Durmo, R., primary, Albano, D., additional, Crisafulli, V., additional, Terraneo, F., additional, Giubbini, R., additional, and Bertagna, F., additional
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- 2020
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16. Cistitis incrustada detectada por PET/TC con 18F-FDG
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Bonacina, M., primary, Albano, D., additional, Durmo, R., additional, Barbera, F., additional, Bertagna, F., additional, and Giubbini, R., additional
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- 2019
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17. Detección de grasa parda en la PET/TC con 18F-FDG: diferencias entre la población adulta y pediátrica en una experiencia de 12 años
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Bonacina, M., primary, Albano, D., additional, Gazzilli, M., additional, Durmo, R., additional, Cerudelli, E., additional, Bosio, G., additional, Bertagna, F., additional, and Giubbini, R., additional
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- 2019
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18. Possible delayed diagnosis and treatment of metastatic differentiated thyroid cancer by adopting the 2015 ATA guidelines
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Albano, D, Bertagna, F, Bonacina, M, Durmo, R, Cerudelli, E, Gazzilli, M, Panarotto, M, Formenti, A, Mazziotti, G, Giustina, A, Giubbini, R, Albano, Domenico, Bertagna, Francesco, Bonacina, Mattia, Durmo, Rexhep, Cerudelli, Elisabetta, Gazzilli, Maria, Panarotto, Maria Beatrice, Formenti, Anna Maria, Mazziotti, Gherardo, Giustina, Andrea, Giubbini, Raffaele, Albano, D, Bertagna, F, Bonacina, M, Durmo, R, Cerudelli, E, Gazzilli, M, Panarotto, M, Formenti, A, Mazziotti, G, Giustina, A, Giubbini, R, Albano, Domenico, Bertagna, Francesco, Bonacina, Mattia, Durmo, Rexhep, Cerudelli, Elisabetta, Gazzilli, Maria, Panarotto, Maria Beatrice, Formenti, Anna Maria, Mazziotti, Gherardo, Giustina, Andrea, and Giubbini, Raffaele
- Abstract
Objective: According to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim of our study was to retrospectively analyze the prevalence of metastatic disease before and after I-131 and to evaluate the influence of the new ATA guidelines in the management of DTC. Methods: We retrospectively analyzed 140 patients showing distant metastases. All metastases were detected by whole-body scan after I-131 and confirmed by histology and/or other imaging modalities. Results: In 26/140 patients metastases were detected before I-131, while in 114/140 were discovered after I-131. Comparing patients with metastases detected before and after I-131, no differences were demonstrated considering age, sex, histotype, tumor size, multifocality of cancer and metastatic localization. Metastatic DTC discovered before radioiodine had higher thyroglobulin and received a higher radioiodine total activity and number of treatments. Considering patients with distant metastases, according to the 2015 ATA guidelines, 38 patients would have been categorized as high risk, 22 as low risk and 80 as intermediate risk. Among intermediate-risk patients, only in 25 cases (31%) I-131 treatment would have been appropriate according to 2015 ATA recommendations; in the remaining 56 cases (69%), I-131 would not have been recommended. Conclusions: According to the 2015 ATA guidelines, most of metastatic patients would not have been treated after surgery, with the risk of late diagnosis and delayed treatment
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- 2018
19. Attenuation correction in myocardial perfusion imaging affects the assessment of infarct size in women with previous inferior infarct
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Peli, A, Camoni, L, Zilioli, V, Durmo, R, Bonacina, M, Bertagna, F, Paghera, B, Giubbini, R, Peli, Alessia, Camoni, Luca, ZILIOLI, VALENTINA, Durmo, Rexhep, Bonacina, Mattia, Bertagna, Francesco, Paghera, Barbara, Giubbini, Raffaele, Peli, A, Camoni, L, Zilioli, V, Durmo, R, Bonacina, M, Bertagna, F, Paghera, B, Giubbini, R, Peli, Alessia, Camoni, Luca, ZILIOLI, VALENTINA, Durmo, Rexhep, Bonacina, Mattia, Bertagna, Francesco, Paghera, Barbara, and Giubbini, Raffaele
- Abstract
Background Myocardial perfusion imaging is a well-established diagnostic tool in patients with known or suspected coronary artery disease. Numerous clinical trials have shown that attenuation correction (AC) in single photon emission computed tomography (SPECT) improves the diagnostic accuracy of myocardial perfusion imaging over non-AC SPECT, differentiating between scar and attenuation artifacts. We have previously shown that attenuation artifacts produce an overestimation of the size of inferior infarcts in the male population. It is assumed that women are less affected by inferior attenuation artifacts than men. Purpose The aim of this study is to evaluate the role of AC in the assessment of infarct size in female patients with a history of myocardial inferior infarct. Patients and methods We studied a population of 66 consecutive women, with a history of previous inferior myocardial infarct, by SPECT/computed tomography (CT) with 370+370 MBq of technetium-99m labeled compounds by a 2-day stress-rest protocol. Both AC and uncorrected gated-SPECT/CT studies were reconstructed after scatter and motion correction by ordered-subset expectation maximization iterative reconstruction and resolution recovery. The coregistration of the transmission and emission scans was verified for all patients; any misalignment was realigned manually. Uncorrected and corrected SPECT images were analyzed by software QPS/QGS package using a 17-segment model. For each segment, perfusion and wall motion were quantified using a five-point score according to the American Society of Nuclear Cardiology guidelines. Summed stress, summed rest score (SRS), and summed difference score of the inferior left ventricle wall (inferior, inferoseptal, inferolateral, and apical inferior segments) were calculated. A linear correlation was used to assess the relationship between perfusion and the regional wall motion score as determined by uncorrected gated-SPECT. Results The results of quantitative analys
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- 2018
20. The impact of spleen metabolic tumor volume on total metabolic tumor volume and prognosis in patients with follicular lymphoma enrolled in FOLL 12 trial.
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Guerra, L., Chauvie, S., Marcheselli, L., Bergesio, F., Durmo, R., Peano, S., Franceschetto, A., Fallanca, F., Pinto, A., Ghiggi, C., Pulsoni, A., Merli, M., Farina, L., Tani, M., Boccomini, C., Musuraca, G., Falini, B., Ballerini, F., Stefani, P., and Bolis, S. A. M.
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FOLLICULAR lymphoma ,SPLEEN ,PROGRESSION-free survival ,PROGNOSIS - Abstract
In the whole population of 690 patients, the tMTV threshold to categorized low and high tumor burden was 224 and 194 ml with and without sMTV, respectively. During the segmentation procedure, it has been observed that frequently spleen MTV (sMTV) heavily influenced the tMTV value, particularly in case of diffuse spleen uptake included in tMTV calculation. [Extracted from the article]
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- 2023
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21. A gene expression signature to predict disease progression for Hodgkin Lymphoma patients who achieve a complete metabolic response after 2 ABVD courses.
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Donati, B., Nizzoli, M. E., Durmo, R., Ruffini, A., Versari, A., Merli, F., Ciarrocchi, A., and Luminari, S.
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GENE expression ,HODGKIN'S disease ,DISEASE progression ,DISEASE relapse - Abstract
We employed a deep gene expression analysis searching for molecular determinants that could anticipate the risk of relapse among patients who achieve a complete metabolic response after 2 ABVD courses (iPET-). Kaplan Meyer curve analysis showed that Cluster 2 patients had a significative reduced PFS as compared to Cluster 1 ( I p i = 0.00043), supporting the prognostic relevance of these genes (Figure 1B). [Extracted from the article]
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- 2023
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22. Prognostic value of the end of induction PET in patients with follicular lymphoma: results from the analysis of FOLL 12 trial.
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Guerra, L., Bergesio, F., Fallanca, F., Chauvie, S., Marcheselli, L., Durmo, R., Peano, S., Franceschetto, A., Pinto, A., Tani, M., Merli, M., Boccomini, C., Musuraca, G., Pulsoni, A., Falini, B., Ghiggi, C., Farina, L., Ballerini, F., Stefani, P., and Bolis, S. A. M.
- Subjects
FOLLICULAR lymphoma ,PROGNOSIS ,POSITRON emission tomography - Abstract
B Aim: b To assess the prognostic value of the PET metabolic response using the Deauville Score at the end of induction (EoI) therapy. In the whole population, the 5 yrs PFS (95% CI) in DS1-2, DS 3 ad DS4-5 was 74% (69-78), 55% (44-65; HR1.90 (1.36-2.66) I p i < 0.001) and 37%(26-48; HR 4.01 (2.90-5.54) I p i < 0.001); DS3 patients had an intermediate 5 yrs PFS rates between those of DS1-2 and DS4-5 patients. B Conclusion: b In FOLL12 trial, EoI-PET according DS criteria was a reliable tool to stratify PFS and OS in advanced follicular lymphoma patients treated with immunochemotherapy; in addition, these data showed DS3 patients as a new category with an intermediate prognosis in terms of PFS. [Extracted from the article]
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- 2023
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23. Possible delayed diagnosis and treatment of metastatic differentiated thyroid cancer by adopting the 2015 ATA guidelines
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Raffaele Giubbini, Mattia Bonacina, Elisabetta Cerudelli, Andrea Giustina, Rexhep Durmo, Maria Gazzilli, Anna Maria Formenti, Francesco Bertagna, Maria Beatrice Panarotto, Gherardo Mazziotti, Domenico Albano, Albano, D, Bertagna, F, Bonacina, M, Durmo, R, Cerudelli, E, Gazzilli, M, Panarotto, M, Formenti, A, Mazziotti, G, Giustina, A, Giubbini, R, Albano, D., Bertagna, F., Bonacina, M., Durmo, R., Cerudelli, E., Gazzilli, M., Panarotto, M. B., Formenti, A. M., Mazziotti, G., Giustina, A., and Giubbini, R.
- Subjects
Male ,Delayed Diagnosis ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Disease ,Iodine Radioisotopes ,Iodine Radioisotope ,0302 clinical medicine ,Endocrinology ,Retrospective Studie ,Whole Body Imaging ,Neoplasm Metastasis ,Thyroid cancer ,Thyroid Neoplasm ,Aged, 80 and over ,Thyroid ,Delayed Diagnosi ,General Medicine ,Middle Aged ,Combined Modality Therapy ,Neoplasm Metastasi ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Thyroidectomy ,Female ,Radiology ,Human ,Adult ,Risk ,medicine.medical_specialty ,Adolescent ,030209 endocrinology & metabolism ,Thyroglobulin ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Thyroid Neoplasms ,Retrospective Studies ,Aged ,business.industry ,Cancer ,Retrospective cohort study ,medicine.disease ,business - Abstract
ObjectiveAccording to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim of our study was to retrospectively analyze the prevalence of metastatic disease before and after I-131 and to evaluate the influence of the new ATA guidelines in the management of DTC.MethodsWe retrospectively analyzed 140 patients showing distant metastases. All metastases were detected by whole-body scan after I-131 and confirmed by histology and/or other imaging modalities.ResultsIn 26/140 patients metastases were detected before I-131, while in 114/140 were discovered after I-131. Comparing patients with metastases detected before and after I-131, no differences were demonstrated considering age, sex, histotype, tumor size, multifocality of cancer and metastatic localization. Metastatic DTC discovered before radioiodine had higher thyroglobulin and received a higher radioiodine total activity and number of treatments. Considering patients with distant metastases, according to the 2015 ATA guidelines, 38 patients would have been categorized as high risk, 22 as low risk and 80 as intermediate risk. Among intermediate-risk patients, only in 25 cases (31%) I-131 treatment would have been appropriate according to 2015 ATA recommendations; in the remaining 56 cases (69%), I-131 would not have been recommended.ConclusionsAccording to the 2015 ATA guidelines, most of metastatic patients would not have been treated after surgery, with the risk of late diagnosis and delayed treatment.
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- 2018
24. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia
- Author
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Takashi Kudo, Ryan Lahey, Cole B. Hirschfeld, Michelle C. Williams, Bin Lu, Mirvat Alasnag, Mona Bhatia, Hee-Seung Henry Bom, Tairkhan Dautov, Reza Fazel, Ganesan Karthikeyan, Felix Y.J. Keng, Ronen Rubinshtein, Nathan Better, Rodrigo Julio Cerci, Sharmila Dorbala, Paolo Raggi, Leslee J. Shaw, Todd C. Villines, João V. Vitola, Andrew D. Choi, Eli Malkovskiy, Benjamin Goebel, Yosef A. Cohen, Michael Randazzo, Thomas N.B. Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez, Andrew J. Einstein, Rodrigo Cerci, Joao V. Vitola, Gerd Hinterleitner, Yao Lu, Olga Morozova, Zhuoran Xu, Yosef Cohen, Andrew Choi, Juan Lopez-Mattei, Purvi Parwani, Mohammad Nawaz Nasery, Artan Goda, Ervina Shirka, Rabie Benlabgaa, Salah Bouyoucef, Abdelkader Medjahedi, Qais Nailli, Mariela Agolti, Roberto Nicolas Aguero, Maria del Carmen Alak, Lucia Graciela Alberguina, Guillermo Arroñada, Andrea Astesiano, Alfredo Astesiano, Carolina Bas Norton, Pablo Benteo, Juan Blanco, Juan Manuel Bonelli, Jose Javier Bustos, Raul Cabrejas, Jorge Cachero, Roxana Campisi, Alejandro Canderoli, Silvia Carames, Patrícia Carrascosa, Ricardo Castro, Oscar Cendoya, Luciano Martin Cognigni, Carlos Collaud, Claudia Cortes, Javier Courtis, Daniel Cragnolino, Mariana Daicz, Alejandro De La Vega, Silvia Teresa De Maria, Horacio Del Riego, Fernando Dettori, Alejandro Deviggiano, Laura Dragonetti, Mario Embon, Ruben Emilio Enriquez, Jorge Ensinas, Fernando Faccio, Adolfo Facello, Diego Garofalo, Ricardo Geronazzo, Natalia Gonza, Lucas Gutierrez, Miguel Angel Guzzo, Victor Hasbani, Melina Huerin, Victor Jäger, Julio Manuel Lewkowicz, Maria Nieves A. López De Munaín, Jose Maria Lotti, Alejandra Marquez, Osvaldo Masoli, Osvaldo Horacio Masoli, Edgardo Mastrovito, Matias Mayoraz, Graciela Eva Melado, Anibal Mele, Maria Fernanda Merani, Alejandro Horacio Meretta, Susana Molteni, Marcos Montecinos, Eduardo Noguera, Carlos Novoa, Claudio Pereyra Sueldo, Sebastian Perez Ascani, Pablo Pollono, Maria Paula Pujol, Alejandro Radzinschi, Gustavo Raimondi, Marcela Redruello, Marina Rodríguez, Matías Rodríguez, Romina Lorena Romero, Arturo Romero Acuña, Federico Rovaletti, Lucas San Miguel, Lucrecia Solari, Bruno Strada, Sonia Traverso, Sonia Simona Traverzo, Maria del Huerto Velazquez Espeche, Juan Sebastian Weihmuller, Juan Wolcan, Susana Zeffiro, Mari Sakanyan, Scott Beuzeville, Raef Boktor, Patrick Butler, Jennifer Calcott, Loretta Carr, Virgil Chan, Charles Chao, Woon Chong, Mark Dobson, D'Arne Downie, Girish Dwivedi, Barry Elison, Jean Engela, Roslyn Francis, Anand Gaikwad, Ashok Gangasandra Basavaraj, Bruce Goodwin, Robert Greenough, Christian Hamilton-Craig, Victar Hsieh, Subodh Joshi, Karin Lederer, Kenneth Lee, Joseph Lee, John Magnussen, Nghi Mai, Gordon Mander, Fiona Murton, Dee Nandurkar, Johanne Neill, Edward O'Rourke, Patricia O'Sullivan, George Pandos, Kunthi Pathmaraj, Alexander Pitman, Rohan Poulter, Manuja Premaratne, David Prior, Lloyd Ridley, Natalie Rutherford, Hamid Salehi, Connor Saunders, Luke Scarlett, Sujith Seneviratne, Deepa Shetty, Ganesh Shrestha, Jonathan Shulman, Vijay Solanki, Tony Stanton, Murch Stuart, Michael Stubbs, Ian Swainson, Kim Taubman, Andrew Taylor, Paul Thomas, Steven Unger, Anthony Upton, Shankar Vamadevan, William Van Gaal, Johan Verjans, Demetrius Voutnis, Victor Wayne, Peter Wilson, David Wong, Kirby Wong, John Younger, Gudrun Feuchtner, Siroos Mirzaei, Konrad Weiss, Natallia Maroz-Vadalazhskaya, Olivier Gheysens, Filip Homans, Rodrigo Moreno-Reyes, Agnès Pasquet, Veronique Roelants, Caroline M. Van De Heyning, Raúl Araujo Ríos, Valentina Soldat-Stankovic, Sinisa Stankovic, Maria Helena Albernaz Siqueira, Augusto Almeida, Paulo Henrique Alves Togni, Jose Henrique Andrade, Luciana Andrade, Carlos Anselmi, Roberta Araújo, Guilherme Azevedo, Sabbrina Bezerra, Rodrigo Biancardi, Gabriel Blacher Grossman, Simone Brandão, Diego Bromfman Pianta, Lara Carreira, Bruno Castro, Tien Chang, Fernando Cunali, Roberto Cury, Roberto Dantas, Fernando de Amorim Fernandes, Andrea De Lorenzo, Robson De Macedo Filho, Fernanda Erthal, Fabio Fernandes, Juliano Fernandes, Thiago Ferreira De Souza, Wilson Furlan Alves, Bruno Ghini, Luiz Goncalves, Ilan Gottlieb, Marcelo Hadlich, Vinícius Kameoka, Ronaldo Lima, Adna Lima, Rafael Willain Lopes, Ricardo Machado e Silva, Tiago Magalhães, Fábio Martins Silva, Luiz Eduardo Mastrocola, Fábio Medeiros, José Claudio Meneghetti, Vania Naue, Danilo Naves, Roberto Nolasco, Cesar Nomura, Joao Bruno Oliveira, Eduardo Paixao, Filipe Penna De Carvalho, Ibraim Pinto, Priscila Possetti, Mayra Quinta, Rodrigo Rizzo Nogueira Ramos, Ricardo Rocha, Alfredo Rodrigues, Carlos Rodrigues, Leila Romantini, Adelina Sanches, Sara Santana, Leonardo Sara da Silva, Paulo Schvartzman, Cristina Sebastião Matushita, Tiago Senra, Afonso Shiozaki, Maria Eduarda Menezes de Siqueira, Cristiano Siqueira, Paola Smanio, Carlos Eduardo Soares, José Soares Junior, Marcio Sommer Bittencourt, Bernardo Spiro, Cláudio Tinoco Mesquita, Jorge Torreao, Rafael Torres, Marly Uellendahl, Guilherme Urpia Monte, Otávia Veríssimo, Estevan Vieira Cabeda, Felipe Villela Pedras, Roberto Waltrick, Marcello Zapparoli, Hamid Naseer, Marina Garcheva-Tsacheva, Irena Kostadinova, Youdaline Theng, Gad Abikhzer, Rene Barette, Benjamin Chow, Dominique Dabreo, Matthias Friedrich, Ria Garg, Mohammed Nassoh Hafez, Chris Johnson, Marla Kiess, Jonathon Leipsic, Eugene Leung, Robert Miller, Anastasia Oikonomou, Stephan Probst, Idan Roifman, Gary Small, Vikas Tandon, Adwait Trivedi, James White, Katherine Zukotynski, Jose Canessa, Gabriel Castro Muñoz, Carmen Concha, Pablo Hidalgo, Cesar Lovera, Teresa Massardo, Luis Salazar Vargas, Pedro Abad, Harold Arturo, Sandra Ayala, Luis Benitez, Alberto Cadena, Carlos Caicedo, Antonio Calderón Moncayo, Sharon Gomez, Claudia T. Gutierrez Villamil, Claudia Jaimes, Juan Londoño, Juan Luis Londoño Blair, Luz Pabon, Mauricio Pineda, Juan Carlos Rojas, Diego Ruiz, Manuel Valencia Escobar, Andres Vasquez, Damiana Vergel, Alejandro Zuluaga, Isabel Berrocal Gamboa, Gabriel Castro, Ulises González, Ana Baric, Tonci Batinic, Maja Franceschi, Maja Hrabak Paar, Mladen Jukic, Petar Medakovic, Viktor Persic, Marina Prpic, Ante Punda, Juan Felipe Batista, Juan Manuel Gómez Lauchy, Yamile Marcos Gutierrez, Rayner Menéndez, Amalia Peix, Luis Rochela, Christoforos Panagidis, Ioannis Petrou, Vaclav Engelmann, Milan Kaminek, Vladimír Kincl, Otto Lang, Milan Simanek, Jawdat Abdulla, Morten Bøttcher, Mette Christensen, Lars Christian Gormsen, Philip Hasbak, Søren Hess, Paw Holdgaard, Allan Johansen, Kasper Kyhl, Bjarne Linde Norgaard, Kristian Altern Øvrehus, Niels Peter Rønnow Sand, Rolf Steffensen, Anders Thomassen, Bo Zerahn, Alfredo Perez, Giovanni Alejandro Escorza Velez, Mayra Sanchez Velez, Islam Shawky Abdel Aziz, Mahasen Abougabal, Taghreed Ahmed, Adel Allam, Ahmed Asfour, Mona Hassan, Alia Hassan, Ahmed Ibrahim, Sameh Kaffas, Ahmed Kandeel, Mohamed Mandour Ali, Ahmad Mansy, Hany Maurice, Sherif Nabil, Mahmoud Shaaban, Ana Camila Flores, Anne Poksi, Juhani Knuuti, Velipekka Kokkonen, Martti Larikka, Valtteri Uusitalo, Matthieu Bailly, Samuel Burg, Jean-François Deux, Vincent Habouzit, Fabien Hyafil, Olivier Lairez, Franck Proffit, Hamza Regaieg, Laure Sarda-Mantel, Vania Tacher, Roman P. Schneider, Harold Ayetey, George Angelidis, Aikaterini Archontaki, Sofia Chatziioannou, Ioannis Datseris, Christina Fragkaki, Panagiotis Georgoulias, Sophia Koukouraki, Maria Koutelou, Eleni Kyrozi, Evangelos Repasos, Petros Stavrou, Pipitsa Valsamaki, Carla Gonzalez, Goleat Gutierrez, Alejandro Maldonado, Klara Buga, Ildiko Garai, Pál Maurovich-Horvat, Erzsébet Schmidt, Balint Szilveszter, Edit Várady, Nilesh Banthia, Jinendra Kumar Bhagat, Rishi Bhargava, Vivek Bhat, Partha Choudhury, Vijay Sai Chowdekar, Aparna Irodi, Shashank Jain, Elizabeth Joseph, Sukriti Kumar, Prof Dr Girijanandan Mahapatra, Deepanjan Mitra, Bhagwant Rai Mittal, Ahmad Ozair, Chetan Patel, Tapan Patel, Ravi Patel, Shivani Patel, Sudhir Saxena, Shantanu Sengupta, Santosh Singh, Bhanupriya Singh, Ashwani Sood, Atul Verma, Erwin Affandi, Padma Savenadia Alam, Edison Edison, Gani Gunawan, Habusari Hapkido, Basuki Hidayat, Aulia Huda, Anggoro Praja Mukti, Djoko Prawiro, Erwin Affandi Soeriadi, Hilman Syawaluddin, Amjed Albadr, Majid Assadi, Farshad Emami, Golnaz Houshmand, Majid Maleki, Maryam Tajik Rostami, Seyed Rasoul Zakavi, Eed Abu Zaid, Svetlana Agranovich, Yoav Arnson, Rachel Bar-Shalom, Alex Frenkel, Galit Knafo, Rachel Lugassi, Israel Shlomo Maor Moalem, Maya Mor, Noam Muskal, Sara Ranser, Aryeh Shalev, Domenico Albano, Pierpaolo Alongi, Gaspare Arnone, Elisa Bagatin, Sergio Baldari, Matteo Bauckneht, Paolo Bertelli, Francesco Bianco, Rachele Bonfiglioli, Roberto Boni, Andrea Bruno, Isabella Bruno, Elena Busnardo, Elena Califaretti, Luca Camoni, Aldo Carnevale, Roberta Casoni, Armando Ugo Cavallo, Giorgio Cavenaghi, Franca Chierichetti, Marcello Chiocchi, Corrado Cittanti, Mauro Colletta, Umberto Conti, Alberto Cossu, Alberto Cuocolo, Marco Cuzzocrea, Maria Luisa De Rimini, Giuseppe De Vincentis, Eleonora Del Giudice, Alberico Del Torto, Veronica Della Tommasina, Rexhep Durmo, Paola Anna Erba, Laura Evangelista, Riccardo Faletti, Evelina Faragasso, Mohsen Farsad, Paola Ferro, Luigia Florimonte, Viviana Frantellizzi, Fabio Massimo Fringuelli, Marco Gatti, Angela Gaudiano, Alessia Gimelli, Raffaele Giubbini, Francesca Giuffrida, Salvatore Ialuna, Riccardo Laudicella, Lucia Leccisotti, Lucia Leva, Riccardo Liga, Carlo Liguori, Giampiero Longo, Margherita Maffione, Maria Elisabetta Mancini, Claudio Marcassa, Elisa Milan, Barbara Nardi, Sara Pacella, Giovanna Pepe, Gianluca Pontone, Sabina Pulizzi, Natale Quartuccio, Lucia Rampin, Fabrizio Ricci, Pierluigi Rossini, Giuseppe Rubini, Vincenzo Russo, Gian Mauro Sacchetti, Gianmario Sambuceti, Massimo Scarano, Roberto Sciagrà, Massimiliano Sperandio, Antonella Stefanelli, Guido Ventroni, Stefania Zoboli, Dainia Baugh, Duane Chambers, Ernest Madu, Felix Nunura, Hiroshi Asano, Chimura Misato Chimura, Shinichiro Fujimoto, Koichiro Fujisue, Tomohisa Fukunaga, Yoshimitsu Fukushima, Kae Fukuyama, Jun Hashimoto, Yasutaka Ichikawa, Nobuo Iguchi, Masamichi Imai, Anri Inaki, Hayato Ishimura, Satoshi Isobe, Toshiaki Kadokami, Takao Kato, Shinichiro Kumita, Hirotaka Maruno, Hiroyuki Mataki, Masao Miyagawa, Ryota Morimoto, Masao Moroi, Shigeki Nagamachi, Kenichi Nakajima, Tomoaki Nakata, Ryo Nakazato, Mamoru Nanasato, Masanao Naya, Takashi Norikane, Yasutoshi Ohta, Satoshi Okayama, Atsutaka Okizaki, Yoichi Otomi, Hideki Otsuka, Masaki Saito, Sakata Yasushi Sakata, Masayoshi Sarai, Daisuke Sato, Shinya Shiraishi, Yoshinobu Suwa, Kentaro Takanami, Kazuya Takehana, Junichi Taki, Nagara Tamaki, Yasuyo Taniguchi, Hiroki Teragawa, Nobuo Tomizawa, Kenichi Tsujita, Kyoko Umeji, Yasushi Wakabayashi, Shinichiro Yamada, Shinya Yamazaki, Tatsuya Yoneyama, Mohammad Rawashdeh, Daultai Batyrkhanov, Khalid Makhdomi, Kevin Ombati, Faridah Alkandari, Masoud Garashi, Tchoyoson Lim Coie, Sonexay Rajvong, Artem Kalinin, Marika Kalnina, Mohamad Haidar, Renata Komiagiene, Giedre Kviecinskiene, Mindaugas Mataciunas, Donatas Vajauskas, Christian Picard, Noor Khairiah A. Karim, Luise Reichmuth, Anthony Samuel, Mohammad Aaftaab Allarakha, Ambedhkar Shantaram Naojee, Erick Alexanderson-Rosas, Erika Barragan, Alejandro Becerril González-Montecinos, Manuel Cabada, Daniel Calderon Rodriguez, Isabel Carvajal-Juarez, Violeta Cortés, Filiberto Cortés, Erasmo De La Peña, Manlio Gama-Moreno, Luis González, Nelsy Gonzalez Ramírez, Moisés Jiménez-Santos, Luis Matos, Edgar Monroy, Martha Morelos, Mario Ornelas, Jose Alberto Ortga Ramirez, Andrés Preciado-Anaya, Óscar Ulises Preciado-Gutiérrez, Adriana Puente Barragan, Sandra Graciela Rosales Uvera, Sigelinda Sandoval, Miguel Santaularia Tomas, Lilia M. Sierra-Galan, Silvia Siu, Enrique Vallejo, Mario Valles, Marc Faraggi, Erdenechimeg Sereegotov, Srdja Ilic, Nozha Ben-Rais, Nadia Ismaili Alaoui, Sara Taleb, Khin Pa Pa Myo, Phyo Si Thu, Ram Kumar Ghimire, Bijoy Rajbanshi, Peter Barneveld, Andor Glaudemans, Jesse Habets, Klaas Pieter Koopmans, Jeroen Manders, Stefan Pool, Arthur Scholte, Asbjørn Scholtens, Riemer Slart, Paul Thimister, Erik-Jan Van Asperen, Niels Veltman, Derk Verschure, Nils Wagenaar, John Edmond, Chris Ellis, Kerryanne Johnson, Ross Keenan, Shaw Hua (Anthony) Kueh, Christopher Occleshaw, Alexander Sasse, Andrew To, Niels Van Pelt, Calum Young, Teresa Cuadra, Hector Bladimir Roque Vanegas, Idrissa Adamou Soli, Djibrillou Moussa Issoufou, Tolulope Ayodele, Chibuzo Madu, Yetunde Onimode, Elen Efros-Monsen, Signe Helene Forsdahl, Jenni-Mari Hildre Dimmen, Arve Jørgensen, Isabel Krohn, Pål Løvhaugen, Anders Tjellaug Bråten, Humoud Al Dhuhli, Faiza Al Kindi, Naeema Al-Bulushi, Zabah Jawa, Naima Tag, Muhammad Shehzad Afzal, Shazia Fatima, Muhammad Numair Younis, Musab Riaz, Mohammad Saadullah, Yariela Herrera, Dora Lenturut-Katal, Manuel Castillo Vázquez, José Ortellado, Afroza Akhter, Dianbo Cao, Stephen Cheung, Xu Dai, Lianggeng Gong, Dan Han, Yang Hou, Caiying Li, Tao Li, Dong Li, Sijin Li, Jinkang Liu, Hui Liu, Ming Yen Ng, Kai Sun, Gongshun Tang, Jian Wang, Ximing Wang, Zhao-Qian Wang, Yining Wang, Yifan Wang, Jiang Wu, Zhifang Wu, Liming Xia, Jiangxi Xiao, Lei Xu, Youyou Yang, Wu Yin, Jianqun Yu, Li Yuan, Tong Zhang, Longjiang Zhang, Yong-Gao Zhang, Xiaoli Zhang, Li Zhu, Ana Alfaro, Paz Abrihan, Asela Barroso, Eric Cruz, Marie Rhiamar Gomez, Vincent Peter Magboo, John Michael Medina, Jerry Obaldo, Davidson Pastrana, Christian Michael Pawhay, Alvin Quinon, Jeanelle Margareth Tang, Bettina Tecson, Kristine Joy Uson, Mila Uy, Magdalena Kostkiewicz, Jolanta Kunikowska, Nuno Bettencourt, Guilhermina Cantinho, Antonio Ferreira, Ghulam Syed, Samer Arnous, Said Atyani, Angela Byrne, Tadhg Gleeson, David Kerins, Conor Meehan, David Murphy, Mark Murphy, John Murray, Julie O'Brien, Ji-In Bang, Henry Bom, Sang-Geon Cho, Chae Moon Hong, Su Jin Jang, Yong Hyu Jeong, Won Jun Kang, Ji-Young Kim, Jaetae Lee, Chang Kyeong Namgung, Young So, Kyoung Sook Won, Venjamin Majstorov, Marija Vavlukis, Barbara Gužic Salobir, Monika Štalc, Theodora Benedek, Imre Benedek, Raluca Mititelu, Claudiu Adrian Stan, Alexey Ansheles, Olga Dariy, Olga Drozdova, Nina Gagarina, Vsevolod Milyevich Gulyaev, Irina Itskovich, Anatoly Karalkin, Alexander Kokov, Ekaterina Migunova, Viktor Pospelov, Daria Ryzhkova, Guzaliya Saifullina, Svetlana Sazonova, Vladimir Sergienko, Irina Shurupova, Tatjana Trifonova, Wladimir Yurievich Ussov, Margarita Vakhromeeva, Nailya Valiullina, Konstantin Zavadovsky, Kirill Zhuravlev, Subhani Okarvi, Dragana Sobic Saranovic, Felix Keng, Jia Hao Jason See, Ramkumar Sekar, Min Sen Yew, Andrej Vondrak, Shereen Bejai, George Bennie, Ria Bester, Gerrit Engelbrecht, Osayande Evbuomwan, Harlem Gongxeka, Magritha Jv Vuuren, Mitchell Kaplan, Purbhoo Khushica, Hoosen Lakhi, Lizette Louw, Nico Malan, Katarina Milos, Moshe Modiselle, Stuart More, Mathava Naidoo, Leonie Scholtz, Mboyo Vangu, Santiago Aguadé-Bruix, Isabel Blanco, Antonio Cabrera, Alicia Camarero, Irene Casáns-Tormo, Hug Cuellar-Calabria, Albert Flotats, Maria Eugenia Fuentes Cañamero, María Elia García, Amelia Jimenez-Heffernan, Rubén Leta, Javier Lopez Diaz, Luis Lumbreras, Juan Javier Marquez-Cabeza, Francisco Martin, Anxo Martinez de Alegria, Francisco Medina, Maria Pedrera Canal, Virginia Peiro, Virginia Pubul-Nuñez, Juan Ignacio Rayo Madrid, Cristina Rodríguez Rey, Ricardo Ruano Perez, Joaquín Ruiz, Gertrudis Sabatel Hernández, Ana Sevilla, Nahla Zeidán, Damayanthi Nanayakkara, Chandraguptha Udugama, Magnus Simonsson, Hatem Alkadhi, Ronny Ralf Buechel, Peter Burger, Luca Ceriani, Bart De Boeck, Christoph Gräni, Alix Juillet de Saint Lager Lucas, Christel H. Kamani, Nadine Kawel-Boehm, Robert Manka, John O. Prior, Axel Rominger, Jean-Paul Vallée, Benjapa Khiewvan, Teerapon Premprabha, Tanyaluck Thientunyakit, Ali Sellem, Kemal Metin Kir, Haluk Sayman, Mugisha Julius Sebikali, Zerida Muyinda, Yaroslav Kmetyuk, Pavlo Korol, Olena Mykhalchenko, Volodymyr Pliatsek, Maryna Satyr, Batool Albalooshi, Mohamed Ismail Ahmed Hassan, Jill Anderson, Punit Bedi, Thomas Biggans, Anda Bularga, Russell Bull, Rajesh Burgul, John-Paul Carpenter, Duncan Coles, David Cusack, Aparna Deshpande, John Dougan, Timothy Fairbairn, Alexia Farrugia, Deepa Gopalan, Alistair Gummow, Prasad Guntur Ramkumar, Mark Hamilton, Mark Harbinson, Thomas Hartley, Benjamin Hudson, Nikhil Joshi, Michael Kay, Andrew Kelion, Azhar Khokhar, Jamie Kitt, Ken Lee, Chen Low, Sze Mun Mak, Ntouskou Marousa, Jon Martin, Elisa Mcalindon, Leon Menezes, Gareth Morgan-Hughes, Alastair Moss, Anthony Murray, Edward Nicol, Dilip Patel, Charles Peebles, Francesca Pugliese, Jonathan Carl Luis Rodrigues, Christopher Rofe, Nikant Sabharwal, Rebecca Schofield, Thomas Semple, Naveen Sharma, Peter Strouhal, Deepak Subedi, William Topping, Katharine Tweed, Jonathan Weir-Mccall, Suhny Abbara, Taimur Abbasi, Brian Abbott, Shady Abohashem, Sandra Abramson, Tarek Al-Abboud, Mouaz Al-Mallah, Omar Almousalli, Karthikeyan Ananthasubramaniam, Mohan Ashok Kumar, Jeffrey Askew, Lea Attanasio, Mallory Balmer-Swain, Richard R. Bayer, Adam Bernheim, Sabha Bhatti, Erik Bieging, Ron Blankstein, Stephen Bloom, Sean Blue, David Bluemke, Andressa Borges, Kelley Branch, Paco Bravo, Jessica Brothers, Matthew Budoff, Renée Bullock-Palmer, Angela Burandt, Floyd W. Burke, Kelvin Bush, Candace Candela, Elizabeth Capasso, Joao Cavalcante, Donald Chang, Saurav Chatterjee, Yiannis Chatzizisis, Michael Cheezum, Tiffany Chen, Jennifer Chen, Marcus Chen, James Clarcq, Ayreen Cordero, Matthew Crim, Sorin Danciu, Bruce Decter, Nimish Dhruva, Neil Doherty, Rami Doukky, Anjori Dunbar, William Duvall, Rachael Edwards, Kerry Esquitin, Husam Farah, Emilio Fentanes, Maros Ferencik, Daniel Fisher, Daniel Fitzpatrick, Cameron Foster, Tony Fuisz, Michael Gannon, Lori Gastner, Myron Gerson, Brian Ghoshhajra, Alan Goldberg, Brian Goldner, Jorge Gonzalez, Rosco Gore, Sandra Gracia-López, Fadi Hage, Agha Haider, Sofia Haider, Yasmin Hamirani, Karen Hassen, Mallory Hatfield, Carolyn Hawkins, Katie Hawthorne, Nicholas Heath, Robert Hendel, Phillip Hernandez, Gregory Hill, Stephen Horgan, Jeff Huffman, Lynne Hurwitz, Ami Iskandrian, Rajesh Janardhanan, Christine Jellis, Scott Jerome, Dinesh Kalra, Summanther Kaviratne, Fernando Kay, Faith Kelly, Omar Khalique, Mona Kinkhabwala, George Kinzfogl Iii, Jacqueline Kircher, Rachael Kirkbride, Michael Kontos, Anupama Kottam, Joseph Krepp, Jay Layer, Steven H. Lee, Jeffrey Leppo, John Lesser, Steve Leung, Howard Lewin, Diana Litmanovich, Yiyan Liu, Kathleen Magurany, Jeremy Markowitz, Amanda Marn, Stephen E. Matis, Michael Mckenna, Tony Mcrae, Fernando Mendoza, Michael Merhige, David Min, Chanan Moffitt, Karen Moncher, Warren Moore, Shamil Morayati, Michael Morris, Mahmud Mossa-Basha, Zorana Mrsic, Venkatesh Murthy, Prashant Nagpal, Kyle Napier, Katarina Nelson, Prabhjot Nijjar, Medhat Osman, Edward Passen, Amit Patel, Pravin Patil, Ryan Paul, Lawrence Phillips, Venkateshwar Polsani, Rajaram Poludasu, Brian Pomerantz, Thomas Porter, Ryan Prentice, Amit Pursnani, Mark Rabbat, Suresh Ramamurti, Florence Rich, Hiram Rivera Luna, Austin Robinson, Kim Robles, Cesar Rodríguez, Mark Rorie, John Rumberger, Raymond Russell, Philip Sabra, Diego Sadler, Mary Schemmer, U. Joseph Schoepf, Samir Shah, Nishant Shah, Sujata Shanbhag, Gaurav Sharma, Steven Shayani, Jamshid Shirani, Pushpa Shivaram, Steven Sigman, Mitch Simon, Ahmad Slim, David Smith, Alexandra Smith, Prem Soman, Aditya Sood, Monvadi Barbara Srichai-Parsia, James Streeter, Albert T, Ahmed Tawakol, Dustin Thomas, Randall Thompson, Tara Torbet, Desiree Trinidad, Shawn Ullery, Samuel Unzek, Seth Uretsky, Srikanth Vallurupalli, Vikas Verma, Alfonso Waller, Ellen Wang, Parker Ward, Gaby Weissman, George Wesbey, Kelly White, David Winchester, David Wolinsky, Sandra Yost, Michael Zgaljardic, Omar Alonso, Mario Beretta, Rodolfo Ferrando, Miguel Kapitan, Fernando Mut, Omoa Djuraev, Gulnora Rozikhodjaeva, Ha Le Ngoc, Son Hong Mai, Xuan Canh Nguyen, Kudo, T, Lahey, R, Hirschfeld, C, Williams, M, Lu, B, Alasnag, M, Bhatia, M, Henry Bom, H, Dautov, T, Fazel, R, Karthikeyan, G, Keng, F, Rubinshtein, R, Better, N, Cerci, R, Dorbala, S, Raggi, P, Shaw, L, Villines, T, Vitola, J, Choi, A, Malkovskiy, E, 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T, Shiozaki, A, Menezes de Siqueira, M, Siqueira, C, Smanio, P, Soares, C, Junior, J, Bittencourt, M, Spiro, B, Mesquita, C, Torreao, J, Torres, R, Uellendahl, M, Monte, G, Veríssimo, O, Cabeda, E, Pedras, F, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Kostadinova, I, Theng, Y, Abikhzer, G, Barette, R, Chow, B, Dabreo, D, Friedrich, M, Garg, R, Hafez, M, Johnson, C, Kiess, M, Leipsic, J, Leung, E, Miller, R, Oikonomou, A, Probst, S, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Canessa, J, Muñoz, G, Concha, C, Hidalgo, P, Lovera, C, Massardo, T, Vargas, L, Abad, P, Arturo, H, Ayala, S, Benitez, L, Cadena, A, Caicedo, C, Moncayo, A, Gomez, S, Gutierrez Villamil, C, Jaimes, C, Londoño, J, Londoño Blair, J, Pabon, L, Pineda, M, Rojas, J, Ruiz, D, Escobar, M, Vasquez, A, Vergel, D, Zuluaga, A, Gamboa, I, Castro, G, González, U, Baric, A, Batinic, T, Franceschi, M, Paar, M, Jukic, M, Medakovic, P, Persic, V, Prpic, M, Punda, A, Batista, J, Gómez Lauchy, J, Gutierrez, Y, Menéndez, R, Peix, A, Rochela, L, Panagidis, C, Petrou, I, Engelmann, V, Kaminek, M, Kincl, V, Lang, O, Simanek, M, Abdulla, J, Bøttcher, M, Christensen, M, Gormsen, L, Hasbak, P, Hess, S, Holdgaard, P, Johansen, A, Kyhl, K, Norgaard, B, Øvrehus, K, Rønnow Sand, N, Steffensen, R, Thomassen, A, Zerahn, B, Perez, A, Escorza Velez, G, Velez, M, Abdel Aziz, I, Abougabal, M, Ahmed, T, Allam, A, Asfour, A, Hassan, M, Hassan, A, Ibrahim, A, Kaffas, S, Kandeel, A, Ali, M, Mansy, A, Maurice, H, Nabil, S, Shaaban, M, Flores, A, Poksi, A, Knuuti, J, Kokkonen, V, Larikka, M, Uusitalo, V, Bailly, M, Burg, S, Deux, J, Habouzit, V, Hyafil, F, Lairez, O, Proffit, F, Regaieg, H, Sarda-Mantel, L, Tacher, V, Schneider, R, Ayetey, H, Angelidis, G, Archontaki, A, Chatziioannou, S, Datseris, I, Fragkaki, C, Georgoulias, P, Koukouraki, S, Koutelou, M, Kyrozi, E, Repasos, E, Stavrou, P, Valsamaki, P, Gonzalez, C, Gutierrez, G, Maldonado, A, Buga, K, Garai, I, Maurovich-Horvat, P, Schmidt, E, Szilveszter, B, Várady, E, Banthia, N, Bhagat, J, Bhargava, R, Bhat, V, Choudhury, P, Chowdekar, V, Irodi, A, Jain, S, Joseph, E, Kumar, S, Girijanandan Mahapatra, P, Mitra, D, Mittal, B, Ozair, A, Patel, C, Patel, T, Patel, R, Patel, S, Saxena, S, Sengupta, S, Singh, S, Singh, B, Sood, A, Verma, A, Affandi, E, Alam, P, Edison, E, Gunawan, G, Hapkido, H, Hidayat, B, Huda, A, Mukti, A, Prawiro, D, Soeriadi, E, Syawaluddin, H, Albadr, A, Assadi, M, Emami, F, Houshmand, G, Maleki, M, Rostami, M, Zakavi, S, Zaid, E, Agranovich, S, Arnson, Y, Bar-Shalom, R, Frenkel, A, Knafo, G, Lugassi, R, Maor Moalem, I, Mor, M, Muskal, N, Ranser, S, Shalev, A, Albano, D, Alongi, P, Arnone, G, Bagatin, E, Baldari, S, Bauckneht, M, Bertelli, P, Bianco, F, Bonfiglioli, R, Boni, R, Bruno, A, Bruno, I, Busnardo, E, Califaretti, E, Camoni, L, Carnevale, A, Casoni, R, Cavallo, A, Cavenaghi, G, Chierichetti, F, Chiocchi, M, Cittanti, C, Colletta, M, Conti, U, Cossu, A, Cuocolo, A, Cuzzocrea, M, De Rimini, M, De Vincentis, G, Del Giudice, E, Del Torto, A, Della Tommasina, V, Durmo, R, Erba, P, Evangelista, L, Faletti, R, Faragasso, E, Farsad, M, Ferro, P, Florimonte, L, Frantellizzi, V, Fringuelli, F, Gatti, M, Gaudiano, A, Gimelli, A, Giubbini, R, Giuffrida, F, Ialuna, S, Laudicella, R, Leccisotti, L, Leva, L, Liga, R, Liguori, C, Longo, G, Maffione, M, Mancini, M, Marcassa, C, Milan, E, Nardi, B, Pacella, S, Pepe, G, Pontone, G, Pulizzi, S, Quartuccio, N, Rampin, L, Ricci, F, Rossini, P, Rubini, G, Russo, V, Sacchetti, G, Sambuceti, G, Scarano, M, Sciagrà, R, Sperandio, M, Stefanelli, A, Ventroni, G, Zoboli, S, Baugh, D, Chambers, D, Madu, E, Nunura, F, Asano, H, Chimura, C, Fujimoto, S, Fujisue, K, Fukunaga, T, Fukushima, Y, Fukuyama, K, Hashimoto, J, Ichikawa, Y, Iguchi, N, Imai, M, Inaki, A, Ishimura, H, Isobe, S, Kadokami, T, Kato, T, Kumita, S, Maruno, H, Mataki, H, Miyagawa, M, Morimoto, R, Moroi, M, Nagamachi, S, Nakajima, K, Nakata, T, Nakazato, R, Nanasato, M, Naya, M, Norikane, T, Ohta, Y, Okayama, S, Okizaki, A, Otomi, Y, Otsuka, H, Saito, M, Sakata, S, Sarai, M, Sato, D, Shiraishi, S, Suwa, Y, Takanami, K, Takehana, K, Taki, J, Tamaki, N, Taniguchi, Y, Teragawa, H, Tomizawa, N, Tsujita, K, Umeji, K, Wakabayashi, Y, Yamada, S, Yamazaki, S, Yoneyama, T, Rawashdeh, M, Batyrkhanov, D, Makhdomi, K, Ombati, K, Alkandari, F, Garashi, M, Coie, T, Rajvong, S, Kalinin, A, Kalnina, M, Haidar, M, Komiagiene, R, Kviecinskiene, G, Mataciunas, M, Vajauskas, D, Picard, C, Karim, N, Reichmuth, L, Samuel, A, Allarakha, M, Naojee, A, Alexanderson-Rosas, E, Barragan, E, González-Montecinos, A, Cabada, M, Rodriguez, D, Carvajal-Juarez, I, Cortés, V, Cortés, F, De La Peña, E, Gama-Moreno, M, González, L, Ramírez, N, Jiménez-Santos, M, Matos, L, Monroy, E, Morelos, M, Ornelas, M, Ortga Ramirez, J, Preciado-Anaya, A, Preciado-Gutiérrez, Ó, Barragan, A, Rosales Uvera, S, Sandoval, S, Tomas, M, Sierra-Galan, L, Siu, S, Vallejo, E, Valles, M, Faraggi, M, Sereegotov, E, Ilic, S, Ben-Rais, N, Alaoui, N, Taleb, S, Pa Myo, K, Thu, P, Ghimire, R, Rajbanshi, B, Barneveld, P, Glaudemans, A, Habets, J, Koopmans, K, Manders, J, Pool, S, Scholte, A, Scholtens, A, Slart, R, Thimister, P, Van Asperen, E, Veltman, N, Verschure, D, Wagenaar, N, Edmond, J, Ellis, C, Johnson, K, Keenan, R, Kueh, S, Occleshaw, C, Sasse, A, To, A, Van Pelt, N, Young, C, Cuadra, T, Roque Vanegas, H, Soli, I, Issoufou, D, Ayodele, T, Madu, C, Onimode, Y, Efros-Monsen, E, Forsdahl, S, Hildre Dimmen, J, Jørgensen, A, Krohn, I, Løvhaugen, P, Bråten, A, Al Dhuhli, H, Al Kindi, F, Al-Bulushi, N, Jawa, Z, Tag, N, Afzal, M, Fatima, S, Younis, M, Riaz, M, Saadullah, M, Herrera, Y, Lenturut-Katal, D, Vázquez, M, Ortellado, J, Akhter, A, Cao, D, Cheung, S, Dai, X, Gong, L, Han, D, Hou, Y, Li, C, Li, T, Li, D, Li, S, Liu, J, Liu, H, Ng, M, Sun, K, Tang, G, Wang, J, Wang, X, Wang, Z, Wang, Y, Wu, J, Wu, Z, Xia, L, Xiao, J, Xu, L, Yang, Y, Yin, W, Yu, J, Yuan, L, Zhang, T, Zhang, L, Zhang, Y, Zhang, X, Zhu, L, Alfaro, A, Abrihan, P, Barroso, A, Cruz, E, Gomez, M, Magboo, V, Medina, J, Obaldo, J, Pastrana, D, Pawhay, C, Quinon, A, Tang, J, Tecson, B, Uson, K, Uy, M, Kostkiewicz, M, Kunikowska, J, Bettencourt, N, Cantinho, G, Ferreira, A, Syed, G, Arnous, S, Atyani, S, Byrne, A, Gleeson, T, Kerins, D, Meehan, C, Murphy, D, Murphy, M, Murray, J, O'Brien, J, Bang, J, Bom, H, Cho, S, Hong, C, Jang, S, Jeong, Y, Kang, W, Kim, J, Namgung, C, So, Y, Won, K, Majstorov, V, Vavlukis, M, Salobir, B, Štalc, M, Benedek, T, Benedek, I, Mititelu, R, Stan, C, Ansheles, A, Dariy, O, Drozdova, O, Gagarina, N, Gulyaev, V, Itskovich, I, Karalkin, A, Kokov, A, Migunova, E, Pospelov, V, Ryzhkova, D, Saifullina, G, Sazonova, S, Sergienko, V, Shurupova, I, Trifonova, T, Ussov, W, Vakhromeeva, M, Valiullina, N, Zavadovsky, K, Zhuravlev, K, Okarvi, S, Saranovic, D, Jason See, J, Sekar, R, Yew, M, Vondrak, A, Bejai, S, Bennie, G, Bester, R, Engelbrecht, G, Evbuomwan, O, Gongxeka, H, Vuuren, M, Kaplan, M, Khushica, P, Lakhi, H, Louw, L, Malan, N, Milos, K, Modiselle, M, More, S, Naidoo, M, Scholtz, L, Vangu, M, Aguadé-Bruix, S, Blanco, I, Cabrera, A, Camarero, A, Casáns-Tormo, I, Cuellar-Calabria, H, Flotats, A, Fuentes Cañamero, M, García, M, Jimenez-Heffernan, A, Leta, R, Diaz, J, Lumbreras, L, Marquez-Cabeza, J, Martin, F, Martinez de Alegria, A, Medina, F, Canal, M, Peiro, V, Pubul-Nuñez, V, Rayo Madrid, J, Rey, C, Perez, R, Ruiz, J, Hernández, G, Sevilla, A, Zeidán, N, Nanayakkara, D, Udugama, C, Simonsson, M, Alkadhi, H, Buechel, R, Burger, P, Ceriani, L, De Boeck, B, Gräni, C, Juillet de Saint Lager Lucas, A, Kamani, C, Kawel-Boehm, N, Manka, R, Prior, J, Rominger, A, Vallée, J, Khiewvan, B, Premprabha, T, Thientunyakit, T, Sellem, A, Kir, K, Sayman, H, Sebikali, M, Muyinda, Z, Kmetyuk, Y, Korol, P, Mykhalchenko, O, Pliatsek, V, Satyr, M, Albalooshi, B, Ahmed Hassan, M, Anderson, J, Bedi, P, Biggans, T, Bularga, A, Bull, R, Burgul, R, Carpenter, J, Coles, D, Cusack, D, Deshpande, A, Dougan, J, Fairbairn, T, Farrugia, A, Gopalan, D, Gummow, A, Ramkumar, P, Hamilton, M, Harbinson, M, Hartley, T, Hudson, B, Joshi, N, Kay, M, Kelion, A, Khokhar, A, Kitt, J, Low, C, Mak, S, Marousa, N, Martin, J, Mcalindon, E, Menezes, L, Morgan-Hughes, G, Moss, A, Murray, A, Nicol, E, Patel, D, Peebles, C, Pugliese, F, Luis Rodrigues, J, Rofe, C, Sabharwal, N, Schofield, R, Semple, T, Sharma, N, Strouhal, P, Subedi, D, Topping, W, Tweed, K, Weir-Mccall, J, Abbara, S, Abbasi, T, Abbott, B, Abohashem, S, Abramson, S, Al-Abboud, T, Al-Mallah, M, Almousalli, O, Ananthasubramaniam, K, Kumar, M, Askew, J, Attanasio, L, Balmer-Swain, M, Bayer, R, Bernheim, A, Bhatti, S, Bieging, E, Blankstein, R, Bloom, S, Blue, S, Bluemke, D, Borges, A, Branch, K, Bravo, P, Brothers, J, Budoff, M, Bullock-Palmer, R, Burandt, A, Burke, F, Bush, K, Candela, C, Capasso, E, Cavalcante, J, Chang, D, Chatterjee, S, Chatzizisis, Y, Cheezum, M, Chen, T, Chen, J, Chen, M, Clarcq, J, Cordero, A, Crim, M, Danciu, S, Decter, B, Dhruva, N, Doherty, N, Doukky, R, Dunbar, A, Duvall, W, Edwards, R, Esquitin, K, Farah, H, Fentanes, E, Ferencik, M, Fisher, D, Fitzpatrick, D, Foster, C, Fuisz, T, Gannon, M, Gastner, L, Gerson, M, Ghoshhajra, B, Goldberg, A, Goldner, B, Gonzalez, J, Gore, R, Gracia-López, S, Hage, F, Haider, A, Haider, S, Hamirani, Y, Hassen, K, Hatfield, M, Hawkins, C, Hawthorne, K, Heath, N, Hendel, R, Hernandez, P, Hill, G, Horgan, S, Huffman, J, Hurwitz, L, Iskandrian, A, Janardhanan, R, Jellis, C, Jerome, S, Kalra, D, Kaviratne, S, Kay, F, Kelly, F, Khalique, O, Kinkhabwala, M, Iii, G, Kircher, J, Kirkbride, R, Kontos, M, Kottam, A, Krepp, J, Layer, J, Lee, S, Leppo, J, Lesser, J, Leung, S, Lewin, H, Litmanovich, D, Liu, Y, Magurany, K, Markowitz, J, Marn, A, Matis, S, Mckenna, M, Mcrae, T, Mendoza, F, Merhige, M, Min, D, Moffitt, C, Moncher, K, Moore, W, Morayati, S, Morris, M, Mossa-Basha, M, Mrsic, Z, Murthy, V, Nagpal, P, Napier, K, Nelson, K, Nijjar, P, Osman, M, Passen, E, Patel, A, Patil, P, Paul, R, Phillips, L, Polsani, V, Poludasu, R, Pomerantz, B, Porter, T, Prentice, R, Pursnani, A, Rabbat, M, Ramamurti, S, Rich, F, Luna, H, Robinson, A, Robles, K, Rodríguez, C, Rorie, M, Rumberger, J, Russell, R, Sabra, P, Sadler, D, Schemmer, M, Schoepf, U, Shah, S, Shah, N, Shanbhag, S, Sharma, G, Shayani, S, Shirani, J, Shivaram, P, Sigman, S, Simon, M, Slim, A, Smith, D, Smith, A, Soman, P, Srichai-Parsia, M, Streeter, J, T, A, Tawakol, A, Thomas, D, Thompson, R, Torbet, T, Trinidad, D, Ullery, S, Unzek, S, Uretsky, S, Vallurupalli, S, Verma, V, Waller, A, Wang, E, Ward, P, Weissman, G, Wesbey, G, White, K, Winchester, D, Wolinsky, D, Yost, S, Zgaljardic, M, Alonso, O, Beretta, M, Ferrando, R, Kapitan, M, Mut, F, Djuraev, O, Rozikhodjaeva, G, Le Ngoc, H, Mai, S, and Nguyen, X
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Heart disease ,business.industry ,cardiac testing ,coronavirus ,COVID-19 ,global health ,Disease ,medicine.disease_cause ,medicine.disease ,coronaviru ,cardiovascular disease ,RC666-701 ,Emergency medicine ,Pandemic ,medicine ,Global health ,Diseases of the circulatory (Cardiovascular) system ,business ,Coronavirus - Abstract
Background: The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known. Objectives: This study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagnostic procedures and safety practices in Asia. Methods: The International Atomic Energy Agency conducted a worldwide survey to assess changes in cardiovascular procedure volume and safety practices caused by COVID-19. Testing volumes were reported for March 2020 and April 2020 and were compared to those from March 2019. Data from 180 centers across 33 Asian countries were grouped into 4 subregions for comparison. Results: Procedure volumes decreased by 47% from March 2019 to March 2020, showing recovery from March 2020 to April 2020 in Eastern Asia, particularly in China. The majority of centers cancelled outpatient activities and increased time per study. Practice changes included implementing physical distancing and restricting visitors. Although COVID testing was not commonly performed, it was conducted in one-third of facilities in Eastern Asia. The most severe reductions in procedure volumes were observed in lower-income countries, where volumes decreased 81% from March 2019 to April 2020. Conclusions: The COVID-19 pandemic in Asia caused significant reductions in cardiovascular diagnostic procedures, particularly in low-income countries. Further studies on effects of COVID-19 on cardiovascular outcomes and changes in care delivery are warranted.
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- 2021
25. Attenuation correction in myocardial perfusion imaging affects the assessment of infarct size in women with previous inferior infarct
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Barbara Paghera, Francesco Bertagna, Alessia Peli, Valentina Zilioli, Luca Camoni, Raffaele Giubbini, Mattia Bonacina, Rexhep Durmo, Peli, A, Camoni, L, Zilioli, V, Durmo, R, Bonacina, M, Bertagna, F, Paghera, B, and Giubbini, R
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Perfusion scanning ,Inferior Wall Myocardial Infarction ,030204 cardiovascular system & hematology ,Single-photon emission computed tomography ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,Myocardial perfusion imaging ,attenuation artifact ,0302 clinical medicine ,Retrospective Studie ,Image Processing, Computer-Assisted ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Retrospective Studies ,Aged ,medicine.diagnostic_test ,inferior myocardial infarct ,business.industry ,Myocardial Perfusion Imaging ,Retrospective cohort study ,General Medicine ,medicine.disease ,Infarct size ,Clinical trial ,Female ,women ,business ,Nuclear medicine ,Correction for attenuation ,Human - Abstract
Background Myocardial perfusion imaging is a well-established diagnostic tool in patients with known or suspected coronary artery disease. Numerous clinical trials have shown that attenuation correction (AC) in single photon emission computed tomography (SPECT) improves the diagnostic accuracy of myocardial perfusion imaging over non-AC SPECT, differentiating between scar and attenuation artifacts. We have previously shown that attenuation artifacts produce an overestimation of the size of inferior infarcts in the male population. It is assumed that women are less affected by inferior attenuation artifacts than men. Purpose The aim of this study is to evaluate the role of AC in the assessment of infarct size in female patients with a history of myocardial inferior infarct. Patients and methods We studied a population of 66 consecutive women, with a history of previous inferior myocardial infarct, by SPECT/computed tomography (CT) with 370+370 MBq of technetium-99m labeled compounds by a 2-day stress-rest protocol. Both AC and uncorrected gated-SPECT/CT studies were reconstructed after scatter and motion correction by ordered-subset expectation maximization iterative reconstruction and resolution recovery. The coregistration of the transmission and emission scans was verified for all patients; any misalignment was realigned manually. Uncorrected and corrected SPECT images were analyzed by software QPS/QGS package using a 17-segment model. For each segment, perfusion and wall motion were quantified using a five-point score according to the American Society of Nuclear Cardiology guidelines. Summed stress, summed rest score (SRS), and summed difference score of the inferior left ventricle wall (inferior, inferoseptal, inferolateral, and apical inferior segments) were calculated. A linear correlation was used to assess the relationship between perfusion and the regional wall motion score as determined by uncorrected gated-SPECT. Results The results of quantitative analysis of non-AC and CT-AC SPECT images, respectively, were as follows: summed stress score: 9.47±5.01 and 6.58±4.77% (P
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- 2018
26. Lymphoma: The Added Value of Radiomics, Volumes and Global Disease Assessment.
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Chauvie S, Castellino A, Bergesio F, De Maggi A, and Durmo R
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- Humans, Hodgkin Disease diagnostic imaging, Lymphoma, Large B-Cell, Diffuse diagnostic imaging, Lymphoma, Follicular diagnostic imaging, Positron Emission Tomography Computed Tomography methods, Radiomics, Lymphoma diagnostic imaging
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Lymphoma represents a condition that holds promise for cure with existing treatment modalities; nonetheless, the primary clinical obstacle lies in advancing therapeutic outcomes by pinpointing high-risk individuals who are unlikely to respond favorably to standard therapy. In this article, the authors will delineate the significant strides achieved in the lymphoma field, with a particular emphasis on the 3 prevalent subtypes: Hodgkin lymphoma, diffuse large B-cell lymphomas, and follicular lymphoma., Competing Interests: Disclosure The authors have no conflicts of interest to disclose related to the subjects, matter or materials discussed in this article., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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27. End of induction [ 18 F]FDG PET is prognostic for progression-free survival and overall survival in follicular lymphoma patients enrolled in the FOLL12 trial.
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Guerra L, Chauvie S, Fallanca F, Bergesio F, Marcheselli L, Durmo R, Peano S, Franceschetto A, Monaco L, Barbieri E, Ladetto M, Musuraca G, Tosi P, Bianchi B, Bolis SAM, Pavone V, Chiarenza A, Arcari A, Califano C, Bari A, Massaia M, Conconi A, Musto P, Mannina D, Roti G, Galimberti S, Gini G, Falcinelli F, Vitolo U, Usai SV, Stefani PM, Ibatici A, Liberati AM, Pennese E, Perrone T, Versari A, and Luminari S
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- Humans, Female, Male, Middle Aged, Aged, Adult, Prognosis, Progression-Free Survival, Aged, 80 and over, Radiopharmaceuticals, Lymphoma, Follicular diagnostic imaging, Lymphoma, Follicular therapy, Fluorodeoxyglucose F18, Positron-Emission Tomography
- Abstract
Purpose: To evaluate the reliability of the Deauville score (DS) in therapy response assessment and to define the prognostic value of the metabolic response of end of induction (EOI) [
18 F]FDG PET (PET) in follicular lymphoma patients., Methods: Adult patients with untreated grade 1-3a FL/ stage II-IV enrolled in the multicentre, prospective, phase III FOLL12 trial (NCT02063685) were randomized to receive standard immunochemotherapy followed by rituximab maintenance (standard arm) versus standard immunochemotherapy followed by response-adapted post-induction management (experimental arm). Baseline and EOI PET were mandatory for the study. All PET scans were centralized on the WIDEN® platform and classified according to DS in a blind independent central review. DS1-3 was considered negative (CMR), whereas DS4-5 was considered positive (not CMR). The primary endpoint was PFS. The main secondary endpoint was overall survival (OS)., Results: Overall, 807 follicular lymphoma patients-52% women, 89% stage III-IV disease, 40% with a high-risk FLIPI-2 score (3-5)-were enrolled in the study; 729 (90.4%) baseline and EOI PET were available for the analysis. EOI PET was positive (DS4-5) in 88/729 (12.1%) cases. Overall inter-reviewer agreement on PET pos/neg result was 0.92, while agreement on positive and negative cases was 0.77 and 0.94, respectively. The median follow-up was 69 months; 247 events were registered in the 5-yr follow-up, with a 5-yr PFS of 67% (95%CI: 63%-70%). The 5-yr PFS rate for PET neg (DS1-3) and PET pos (DS4-5) patients was 71% (95%CI: 67%-75%) and 36% (95%CI: 25%-46%), respectively, with HR 3.49 (95%CI: 2.57-4.72). Five-year PFS was worse as DS increased, with 74% (70%-78%), 58% (48%-67%; HR 1.71; p = 0.001)] and 36% (25%-46%; HR 3.88; p < 0.001) in DS1-2, DS3 and DS4-5, respectively. EOI PET maintained its prognostic value in both the standard and experimental arms. In the whole population, 5-yr OS was 94% (95%CI: 92%-96%), with 96% (95%CI: 94-97) and 82% (95%CI: 72%-89%) in EOI PET negative (DS1-3) and positive (DS4-5), respectively (HR 4.48; p < 0.001). When DS was associated with FLIPI-2, patients with DS3 or DS1-2 with high FLIPI-2 (3-5) experienced worse OS than patients with DS1-2 and low FLIPI-2 (1-2) (p = 0.003)., Conclusion: This study shows that DS is a reliable prognostic tool to evaluate EOI PET in follicular lymphoma patients, with prognostic value maintained both in the standard and experimental arms, making metabolic imaging a robust tool to assess response in FL. Moreover, although preliminary, this study provides further information on DS3 patients, who are considered as CMR but show a less favourable PFS than DS1-2 patients., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)- Published
- 2024
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28. Treatment of giant cell arteritis with ultra-short glucocorticoids and tocilizumab: results from the extension of the TOPAZIO study.
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Muratore F, Marvisi C, Cassone G, Ricordi C, Boiardi L, Mancuso P, Besutti G, Spaggiari L, Casali M, Croci S, Durmo R, Versari A, Di Tommaso G, Catanoso M, Giorgi Rossi P, and Salvarani C
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Objectives: To assess the maintenance of efficacy of one year of tocilizumab (TCZ) monotherapy after its discontinuation in large vessel-GCA (LV-GCA)., Methods: 17 patients with active LV-GCA were previously treated with 3 boluses of intravenous methylprednisone and weekly subcutaneous TCZ in monotherapy for 52 weeks. Patients in relapse-free clinical remission at week 52 discontinued TCZ and entered part two, which was a 26-week observational follow-up period. PET/CT was performed in all patients at the end of the 26-week observational period (week 78). End points were the variation in PET vascular activity score (PETVAS) at week 78 compared with baseline and with week 52, and the proportion of patients with relapse-free clinical remission at week 78 and at the end of the follow-up., Results: Compared with baseline, a significant reduction in PETVAS was observed at week 78, mean (95% CI) change -6.6 (-9.5 to -3.7). However, compared with week 52, PETVAS significantly increase 6 months after TCZ discontinuation (week 78), mean (95% CI) change 4.6 (0.7-8.5). The proportion of patients with relapse-free clinical remission at weeks 78 and at the end of the follow-up (median time from TCZ discontinuation 148 weeks) was 11/17 (65%, 95% CI 38-86) and 8/17 (47%, 95% CI 23-72), respectively. Age and sex-adjusted HR (95% CI) for each unit increase of PETVAS indicating subsequent relapse was 1.36 (0.92-2.00)., Conclusions: One year of TCZ monotherapy was effective in maintaining drug-free clinical remission in LV-GCA. Changes in PETVAS early after TCZ discontinuation may predict subsequent relapses., Clinical Trial Registration: ClinicalTrials.gov, NCT05394909., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2024
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29. Prevalence and distribution of vascular calcifications at CT scan in patients with and without large vessel vasculitis: a matched cross-sectional study.
- Author
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Besutti G, Marvisi C, Mancuso P, Farì R, Monelli F, Revelli M, Durmo R, Galli E, Muratore F, Spaggiari L, Ottone M, Luminari S, Pattacini P, Giorgi Rossi P, and Salvarani C
- Subjects
- Humans, Middle Aged, Cross-Sectional Studies, Prevalence, Positron Emission Tomography Computed Tomography, Retrospective Studies, Tomography, X-Ray Computed, Vascular Calcification diagnostic imaging, Vascular Calcification epidemiology, Vasculitis
- Abstract
Objectives: The aim of this study was to compare the prevalence, entity and local distribution of arterial wall calcifications evaluated on CT scans in patients with large vessel vasculitis (LVV) and patients with lymphoma as reference for the population without LVV., Methods: All consecutive patients diagnosed with LVVs with available baseline positron emission tomography-CT (PET-CT) scan performed between 2007 and 2019 were included; non-LVV patients were lymphoma patients matched by age (±5 years), sex and year of baseline PET-CT (≤2013; >2013). CT images derived from baseline PET-CT scans of both patient groups were retrospectively reviewed by a single radiologist who, after setting a threshold of minimum 130 Hounsfield units, semiautomatically computed vascular calcifications in three separate locations (coronaries, thoracic and abdominal arteries), quantified as Agatston and volume scores., Results: A total of 266 patients were included. Abdominal artery calcifications were equally distributed (mean volume 3220 in LVVs and 2712 in lymphomas). Being in the LVVs group was associated with the presence of thoracic calcifications after adjusting by age and year of diagnosis (OR 4.13, 95% CI 1.35 to 12.66; p=0.013). Similarly, LVVs group was significantly associated with the volume score in the thoracic arteries (p=0.048). In patients >50 years old, calcifications in the coronaries were more extended in non-LVV patients (p=0.027 for volume)., Conclusion: When compared with patients without LVVs, LVVs patients have higher calcifications in the thoracic arteries, but not in coronary and abdominal arteries., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
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30. The diagnostic and prognostic role of combined [ 18 F]FDG and [ 68 Ga]-DOTA-peptides PET/CT in primary pulmonary carcinoids: a multicentric experience.
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Albano D, Dondi F, Bauckneht M, Albertelli M, Durmo R, Filice A, Versari A, Morbelli S, Berruti A, and Bertagna F
- Subjects
- Fluorodeoxyglucose F18 administration & dosage, Heterocyclic Compounds, 1-Ring administration & dosage, Prognosis, Humans, Male, Female, Adult, Middle Aged, Aged, Aged, 80 and over, Positron Emission Tomography Computed Tomography, Carcinoid Tumor diagnostic imaging, Lung Neoplasms diagnostic imaging
- Abstract
Objectives: In the present retrospective multicentric study, we combined [
68 Ga]-DOTA-peptides and [18 F]FDG-PET/CT findings aiming to investigate their capability to differentiate typical (TC) and atypical pulmonary carcinoids (AC) and their prognostic role., Methods: From three centers, 61 patients were retrospectively included. Based on a dual tracer combination we classified PET scans as score 1, [18 F]FDG- and [68 Ga]-DOTA-peptides negative; score 2, [68Ga]-DOTA-peptides positive and [18 F]FDG-negative; score 3, [68 Ga]-DOTA-peptides negative and [18 F]FDG-positive; score 4, both tracers positive. Moreover, for each patient, the ratios of SUVmax on [68 Ga]-DOTA-PET to that on [18 F]FDG-PET were calculated (SUVr)., Results: Thirty-five patients had a final diagnosis of TC. Twenty-two TC (57%) had positive [68 Ga]-DOTA-peptides PET; instead, 21/26 (81%) AC had positive [18 F]FDG-PET/CT. On dual-tracer analysis, scores 1, 2, 3 and 4 were 13%, 20%, 43% and 24% for all populations; 17%, 26%, 20% and 37% for TC; 8%, 11%, 73% and 8% for AC. Median SUVr was significantly higher in TC than AC (6.4 vs. 0.4, p = 0.011). The best value of SUVr to predict the final diagnosis was 1.05 (AUC 0.889). Relapse or progression of disease happened in 17 patients (11 affected by AC) and death in 10 cases (7 AC). AC diagnosis, positive [18 F]FDG-PET, negative DOTA-PET and dual tracer score were significantly correlated with PFS (p = 0.013, p = 0.033, p = 0.029 and p = 0.019), while only AC diagnosis with OS (p = 0.022)., Conclusion: PET/CT findings had also a prognostic role in predicting PFS. Dual-tracer PET behavior may be used to predict the nature of pulmonary carcinoids and select the most appropriate management., Key Points: • Combination of [18F]FDG and [68Ga]-DOTA-peptides PET/CT results may help to differentiate between atypical and typical lung carcinoids. • The SUVmax ratio between [18F]FDG and [68Ga]-DOTA-peptides PET may help to differentiate between atypical and typical lung carcinoids. • Histotype and PET/CT features have a prognostic impact on PFS., (© 2022. The Author(s), under exclusive licence to European Society of Radiology.)- Published
- 2023
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31. Prognostic value of lesion dissemination in doxorubicin, bleomycin, vinblastine, and dacarbazine-treated, interimPET-negative classical Hodgkin Lymphoma patients: A radio-genomic study.
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Durmo R, Donati B, Rebaud L, Cottereau AS, Ruffini A, Nizzoli ME, Ciavarella S, Vegliante MC, Nioche C, Meignan M, Merli F, Versari A, Ciarrocchi A, Buvat I, and Luminari S
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bleomycin therapeutic use, Dacarbazine therapeutic use, Doxorubicin therapeutic use, Fluorodeoxyglucose F18 therapeutic use, Genomics, Humans, Positron-Emission Tomography methods, Prognosis, RNA therapeutic use, Retrospective Studies, Vinblastine therapeutic use, Hodgkin Disease diagnostic imaging, Hodgkin Disease drug therapy, Hodgkin Disease genetics
- Abstract
We evaluated the prognostic role of the largest distance between two lesions (Dmax), defined by positron emission tomography (PET) in a retrospective cohort of newly diagnosed classical Hodgkin Lymphoma (cHL) patients. We also explored the molecular bases underlying Dmax through a gene expression analysis of diagnostic biopsies. We included patients diagnosed with cHL from 2007 to 2020, initially treated with ABVD, with available baseline PET for review, and with at least two FDG avid lesions. Patients with available RNA from diagnostic biopsy were eligible for gene expression analysis. Dmax was deduced from the three-dimensional coordinates of the baseline metabolic tumor volume (MTV) and its effect on progression free survival (PFS) was evaluated. Gene expression profiles were correlated with Dmax and analyzed using CIBERSORTx algorithm to perform deconvolution. The study was conducted on 155 eligible cHL patients. Using its median value of 20 cm, Dmax was the only variable independently associated with PFS (HR = 2.70, 95% CI 1.1-6.63, pValue = 0.03) in multivariate analysis of PFS for all patients and for those with early complete metabolic response (iPET-). Among patients with iPET-low Dmax was associated with a 4-year PFS of 90% (95% CI 82.0-98.9) significantly better compared to high Dmax (4-year PFS 72.4%, 95% CI 61.9-84.6). From the analysis of gene expression profiles differences in Dmax were mostly associated with variations in the expression of microenvironmental components. In conclusion our results support tumor dissemination measured through Dmax as novel prognostic factor for cHL patients treated with ABVD., (© 2022 The Authors. Hematological Oncology published by John Wiley & Sons Ltd. -.)
- Published
- 2022
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32. Predictive and Prognostic Role of Pre-Therapy and Interim 68Ga-DOTATOC PET/CT Parameters in Metastatic Advanced Neuroendocrine Tumor Patients Treated with PRRT.
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Durmo R, Filice A, Fioroni F, Cervati V, Finocchiaro D, Coruzzi C, Besutti G, Fanello S, Frasoldati A, and Versari A
- Abstract
Peptide receptor radionuclide therapy (PRRT) is an effective therapeutic option in patients with metastatic neuroendocrine tumor (NET). However, PRRT fails in about 15-30% of cases. Identification of biomarkers predicting the response to PRRT is essential for treatment tailoring. We aimed to evaluate the predictive and prognostic role of semiquantitative and volumetric parameters obtained from the 68Ga-DOTATOC PET/CT before therapy (bPET) and after two cycles of PRRT (iPET). A total of 46 patients were included in this retrospective analysis. The primary tumor was 78% gastroenteropancreatic (GEP), 13% broncho-pulmonary and 9% of unknown origin. 35 patients (76.1%) with stable disease or partial response after PRRT were classified as responders and 11 (23.9%) as non-responders. Logistic regression analysis identified that baseline total volume (bTV) was associated with therapy outcome (OR 1.17; 95%CI 1.02-1.32; p = 0.02). No significant association with PRRT response was observed for other variables. High bTV was confirmed as the only variable independently associated with OS (HR 12.76, 95%CI 1.53-107, p = 0.01). In conclusion, high bTV is a negative predictor for PRRT response and is associated with worse OS rates. Early iPET during PRRT apparently does not provide information useful to change the management of NET patients.
- Published
- 2022
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33. The prognostic power of 18F-FDG PET/CT extends to estimating systemic treatment response duration in metastatic castration-resistant prostate cancer (mCRPC) patients.
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Bauckneht M, Bertagna F, Donegani MI, Durmo R, Miceli A, De Biasi V, Laudicella R, Fornarini G, Berruti A, Baldari S, Versari A, Giubbini R, Sambuceti G, Morbelli S, and Albano D
- Subjects
- Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Tumor analysis, Fluorodeoxyglucose F18, Humans, Italy, Male, Middle Aged, Neoplasm Grading, Prognosis, Prostatic Neoplasms, Castration-Resistant pathology, Radiopharmaceuticals, Retrospective Studies, Tumor Burden, Positron Emission Tomography Computed Tomography, Prostatic Neoplasms, Castration-Resistant diagnostic imaging, Prostatic Neoplasms, Castration-Resistant drug therapy
- Abstract
Background: We aimed to test whether the prognostic value of 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT) in metastatic castration-resistant prostate cancer (mCRPC) extends to the estimation of systemic treatment response duration., Methods: mCRPC patients submitted to FDG-PET/CT in four Italian centers from 2005 to 2020 were retrospectively enrolled. Clinical and biochemical data at the time of imaging were collected, and SUV max of the hottest lesion, total metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were calculated. The correlation between PET- and biochemical-derived parameters with Overall Survival (OS) was analysed. The prediction of treatment response duration was assessed in the subgroup submitted to FDG-PET/CT in the six months preceding Chemotherapy (namely Docetaxel or Cabazitaxel, 24 patients) or Androgen-Receptor Targeted Agents (ARTA, namely Abiraterone or Enzalutamide, 20 patients) administration., Results: We enrolled 114 mCRPC patients followed-up for a median interval lasting 15 months. While at univariate analysis, prostate-specific antigen (PSA), Alkaline Phosphatase (ALP), MTV, and TLG were associated with OS, at the multivariate Cox regression analysis, the sole MTV could independently predict OS (p < 0.0001). In the subgroup submitted to FDG-PET/CT before the systemic treatment initiation, PSA and TLG could also predict treatment response duration independently (p < 0.05). Of note, while PSA could not indicate the best treatment choice, lower TLG was associated with higher success rates for ARTA but had no impact on chemotherapy efficacy., Conclusions: FDG-PET/CT's prognostic value extends to predicting treatment response duration in mCRPC, thus potentially guiding the systemic treatment selection., (© 2021. The Author(s).)
- Published
- 2021
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34. Comparison between N 13 NH 3 -PET and 99m Tc-Tetrofosmin-CZT SPECT in the evaluation of absolute myocardial blood flow and flow reserve.
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Giubbini R, Bertoli M, Durmo R, Bonacina M, Peli A, Faggiano I, Albano D, Milan E, Stern E, Paghera B, Rodella C, Cerudelli E, Gazzilli M, Dondi F, Bertagna F, and Camoni L
- Subjects
- Adult, Aged, Aged, 80 and over, Ammonia, Cadmium, Coronary Circulation physiology, Female, Humans, Male, Middle Aged, Nitrogen Radioisotopes, Organophosphorus Compounds, Organotechnetium Compounds, Predictive Value of Tests, ROC Curve, Radiopharmaceuticals, Tellurium, Zinc, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease physiopathology, Fractional Flow Reserve, Myocardial physiology, Myocardial Perfusion Imaging, Positron Emission Tomography Computed Tomography, Tomography, Emission-Computed, Single-Photon
- Abstract
Background: PET/CT is the standard for quantitative assessments of myocardial blood flow (MBF), but it requires short-lived-tracers, costly, and not widely available. SPECT with Cadmium Zinc Telluride (CZT) detectors allows dynamic acquisition and quantitation of MBF. The study aims were to compare MBF measurements by
99m Tc-tetrofosmin-CZT to N13 NH3 PET/CT after regadenoson-induced coronary hyperemia and to evaluate the effect of attenuation correction (AC)., Methods: 54 patients were evaluated at rest and during vasodilation by99m Tc-tetrofosmin-CZT and N13 NH3 PET/CT within 2 weeks. MBF and MBF reserve (MFR) were measured by CZT with or without AC (NAC)., Results: The global rest MBF was 0.76 ± 0.19 mL/min/gr by PET and 0.76 ± 0.24 by AC-CZT (P = NS) and 1.14 ± 0.4 by NAC-CZT (P < 0.001 vs PET and AC-CZT). Stress MBF was higher when measured by PET than AC-CZT (1.87 ± 0.45 vs 1.62 ± 0.68 mL/min/gr, P < 0.0008), but lower than NAC-CZT (2.36 ± 1.1, P < 0.0003). The MBF reserve ratio (MFR) was higher by PET than AC-CZT (2.52 ± 0.56 vs 2.22 ± 1 (P < 0.009) and NAC-CZT (2.18 ± 1.0, P < 0.004). Linear regression was better between PET (MFR and stress MBF) and AC-CZT than between PET and NAC-CZT. ROC curve analysis showed the significant ability of AC-CZT to predict MFR < 2 and stress MBF < 1.7 (AUC = 0.75 and 0.82 respectively) and to differentiate between normal and CAD patients (AUC = 0.747 and 0.892 for MFR and stress MBF, respectively)., Conclusions: Our data show a reasonable correlation between MBF and MFR measured by N13 NH3 -PET and99m Tc-Tetrofosmin-CZT SPECT. NAC-CZT overestimates MBF. AC is recommended when using CZT for measuring MBF., (© 2019. American Society of Nuclear Cardiology.)- Published
- 2021
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35. Cardiac amyloidosis incidentally detected by 18F-FDG PET/CT.
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Gazzilli M, Bertoli M, Albano D, Durmo R, Cerudelli E, Bertagna F, and Giubbini R
- Subjects
- Contrast Media, Humans, Incidental Findings, Magnetic Resonance Imaging, Male, Middle Aged, Multimodal Imaging, Solitary Pulmonary Nodule complications, Solitary Pulmonary Nodule diagnostic imaging, Amyloidosis diagnostic imaging, Fluorodeoxyglucose F18, Heart diagnostic imaging, Positron Emission Tomography Computed Tomography methods
- Published
- 2020
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36. Improvement of diagnostic accuracy of 18fluorine-fluorodeoxyglucose PET/computed tomography in detection of infective endocarditis using a 72-h low carbs protocol.
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Gazzilli M, Albano D, Durmo R, Cerudelli E, Mesquita Tinoco C, Bertagna F, and Giubbini R
- Subjects
- Diet, High-Fat, Female, Humans, Male, Middle Aged, ROC Curve, Retrospective Studies, Diet, High-Protein Low-Carbohydrate, Endocarditis diagnostic imaging, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography
- Abstract
Background: The major challenge in diagnosing infective endocarditis using fluorine-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is the high physiological myocardial F-FDG uptake, which may interfere with the detection of pathological uptake. Our aim was to retrospectively analyse the impact of a low-carbohydrate, high-protein, high-fat (LCHPHF) diet starting 72 h before the examination with classic overnight fasting., Methods: We included 92 patients (51 with LCHPHF diet 72 h before the examination and 41 with overnight fast only). Left ventricular (LV) myocardial F-FDG uptake was visually evaluated, to estimate the effect of LCHPHF on myocardial F-FDG uptake, we used a three-point visual scale: 0, negligible uptake and evaluable examination; 1, mild uptake and doubtful examination and 2, intense uptake and not evaluable examination. SUVmax and SUVmean were calculated putting a region of interest on LV myocardium at the level of the largest cardiac footprint and on the site of suspected lesion. Thus, a ratio between SUV of the suspect lesion and SUV of LV was calculated as SUV ratio., Results: By visual assessment, in LCHPHF diet group 46 patients (96.1%) had score 0, 3 patients (5.9%) had score 1 and nobody had score 2. In control group, 23 patients (56.1%) had a score 2, 12 (29.3%) patients obtained a score 1 with a doubtful examination and 6 patients (14.6%) were classified with a score 0 with reportable examination., Conclusion: We demonstrated that an LCHPHF diet can adequately suppress the physiological myocardial uptake leading to a significant improvement in the interpretability and diagnostic accuracy of F-FDG PET/CT in infective endocarditis.
- Published
- 2020
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37. Three years' clinical practice of Radium-223 therapy in patients with symptomatic bone metastases from metastatic castrate-resistant prostate cancer: a single-centre experience.
- Author
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Gazzilli M, Durmo R, Cossalter E, Cerudelli E, Panarotto MB, Albano D, Bertagna F, and Giubbini R
- Subjects
- Aged, Aged, 80 and over, Bone Neoplasms diagnostic imaging, Humans, Male, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Treatment Outcome, Bone Neoplasms radiotherapy, Bone Neoplasms secondary, Prostatic Neoplasms, Castration-Resistant pathology, Radium therapeutic use
- Abstract
Background: Radium-223 was a treatment approved for patients with metastatic castrate-resistant prostate cancer, symptomatic bone metastases and no-visceral metastases, in progression after at least two prior lines of systemic therapy, or ineligible for any available systemic treatment. The aim of this study was to provide further characterization and sub-selection of patients who would benefit most with Radium-223 treatment., Methods: We retrospectively analysed 38 patients treated with Radium-223 between 2015 and 2018. All patients underwent a baseline visit and a bone scintigraphy. Bone scan, ALP and PSA levels were repeated after third and after the end of therapy. All patients were re-evaluated after 2 months from the end of therapy. Survival curves were plotted according to the Kaplan-Meier method and differences between groups were analysed by using a two-tailed log-rank test., Results: The response to the treatment in term of change in pain was reduction in 16 patients; no change in 14 and increased in eight. We arbitrarily established a cut-off 10 bone lesions to evaluate the response: patients with less than 10 metastasis had significant differences in PFS (P < 0.001) compared to patients with more than 10, no statistical significance was found considering the OS (P = 0.23) between the two groups. The same results were founded in patients with baseline ALP <220 U/L with a PFS (P < 0.001) and OS (P = 0.027)., Conclusion: The most important finding was the correlation between the number of bone metastasis and ALP with outcome survival and efficacy of Radium-223 treatment.
- Published
- 2020
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38. Efficacy of low radioiodine activity versus intermediate-high activity in the ablation of low-risk differentiated thyroid cancer.
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Albano D, Bonacina M, Durmo R, Bertagna F, and Giubbini R
- Subjects
- Humans, Retrospective Studies, Thyroidectomy, Treatment Outcome, Iodine Radioisotopes therapeutic use, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms radiotherapy, Thyroid Neoplasms surgery
- Abstract
Purpose: The aim of our study was to compare the efficacy of thyroid remnant ablation using low (1.1 GBq) and intermediate-high radioiodine (RAI) activity (1.85-3.7 GBq) in low-risk differentiated thyroid carcinoma (DTC) and to evaluate the staging role of the whole body scan (WBS) in detection extrathyroidal disease., Materials and Methods: We retrospectively included 277 patients who underwent total thyroidectomy and RAI for low-risk DTC and divided them in two groups according to RAI activity at ablation: group 1 (n = 174) treated with low activity (1.1 GBq), and group 2 (n = 103) with intermediate-high activity (1.85-3.7 GBq). To evaluate the successful ablation rate, the WBS 1 year after RAI was visually interpreted using a three-point scale: score 0 in case of absence of visible RAI uptake in thyroid bed; score 1 in presence of faint uptake in the thyroid bed; and score 2 in case of significant RAI uptake in thyroid bed., Results: The success ablation rate was significantly higher in group 2 than group 1 (p < 0.001) with the presence of a positive WBS (score 1-2) in 65% low-activity group and 33% in intermediate-high group. Considering response to therapy categories, excellent response rate was significantly higher in group 2 (p = 0.020), while indeterminate response was higher in group 1 (p value = 0.005). Post RAI imaging revealed extrathyroidal uptake in 27 cases: 17 laterocervical nodal and 10 distant metastases. In both groups similar detection rate of nodal and distant metastases were recognized without any statistical difference., Conclusions: The ablation rate with intermediate-high RAI activity (1.85-3.7 GBq) was better than with a low activity (1.1 GBq). First WBS may help to recognize nodal and distant metastases in about 10% of cases changing clinical stage and subsequent management.
- Published
- 2020
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39. 18 F-FDG PET/CT or PET Role in MALT Lymphoma: An Open Issue not Yet Solved-A Critical Review.
- Author
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Albano D, Durmo R, Treglia G, Giubbini R, and Bertagna F
- Subjects
- Female, Fluorodeoxyglucose F18 pharmacology, Humans, Male, Prognosis, Retrospective Studies, Fluorodeoxyglucose F18 therapeutic use, Lymphoma, B-Cell, Marginal Zone diagnostic imaging, Positron Emission Tomography Computed Tomography methods
- Abstract
Mucosa-associated lymphoid tissue (MALT) lymphoma involves the mucosa-associated lymphoid tissue potentially arising from any mucosal site, with the stomach as the most common site of involvement. MALT lymphoma is not usually an aggressive disease with a good prognosis except for selected cases. Fluorine-18 (
18 F) fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is a noninvasive imaging tool used for staging, restaging, and evaluation of the treatment response in non-Hodgkin and Hodgkin lymphoma. However, its effective role in MALT lymphoma is not yet clear. The open question is whether these lymphomas are18 F-FDG avid or not, with conflicting results reported in the literature. Consequently, the possible clinical role of18 F-FDG PET/CT for staging and restaging purposes is under debate. The aim of the present review was to analyze the reported data about the role of18 F-FDG PET or PET/CT in patients with MALT lymphoma. We performed a comprehensive computer literature search of the Scopus, Cochrane, PubMed/MEDLINE, and Embase databases, including articles reported up to August 2019. We included 32 studies that had analyzed18 F-FDG PET or PET/CT for patients with MALT lymphoma. We analyzed the metabolic behavior of MALT lymphoma using18 F-FDG PET and the effect of the PET findings in the staging, treatment response evaluation, and prognosis., (Copyright © 2019 Elsevier Inc. All rights reserved.)- Published
- 2020
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40. Nonfunctioning paraganglioma incidentally detected by 18 F-FDG PET/CT and confirmed by 123 I-MIBG M scintigraphy.
- Author
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Durmo R, Albano D, Crisafulli V, Terraneo F, Giubbini R, and Bertagna F
- Subjects
- Aorta diagnostic imaging, Female, Humans, Iodine Radioisotopes, Middle Aged, Paraganglioma pathology, 3-Iodobenzylguanidine, Fluorodeoxyglucose F18, Incidental Findings, Paraganglioma diagnostic imaging, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals
- Published
- 2020
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41. The Role of 18F-FDG PET/CT in Staging and Prognostication of Mantle Cell Lymphoma: An Italian Multicentric Study.
- Author
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Albano D, Laudicella R, Ferro P, Allocca M, Abenavoli E, Buschiazzo A, Castellino A, Chiaravalloti A, Cuccaro A, Cuppari L, Durmo R, Evangelista L, Frantellizzi V, Kovalchuk S, Linguanti F, Santo G, Bauckneht M, and Annunziata S
- Abstract
Mantle cell lymphoma (MCL) is an aggressive lymphoma subtype with poor prognosis in which 18F-FDG-PET/CT role in treatment response evaluation and prediction of outcome is still unclear. The aim of this multicentric study was to investigate the role of 18F-FDG-PET/CT in staging MCL and the prognostic role of Deauville criteria (DC) in terms of progression-free survival (PFS) and overall survival (OS). We retrospectively enrolled 229 patients who underwent baseline and end-of-treatment (eot) 18F-FDG-PET/CT after first-line therapy. EotPET/CT scans were visually interpreted according to DC. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of bone marrow (BM) were 27%, 100%, 100%, 48% and 57%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of the gastrointestinal (GI) tract were 60%, 99%, 93%, 90% and 91%, respectively. At a median follow-up of 40 months, relapse occurred in 104 cases and death in 49. EotPET/CT results using DC significantly correlated with PFS, not with OS. Instead, considering OS, only MIPI score was significantly correlated. In conclusion, we demonstrated that MCL is an FDG-avid lymphoma and 18F-FDG-PET/CT is a useful tool for staging purpose, showing good specificity for BM and GI evaluation, but suboptimal sensitivity. EotPET/CT result was the only independent significant prognostic factor that correlated with PFS., Competing Interests: The authors declare they have no conflict of interest.
- Published
- 2019
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42. Encrusted cystitis detected by 18 F-FDG PET/CT.
- Author
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Bonacina M, Albano D, Durmo R, Barbera F, Bertagna F, and Giubbini R
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- Aged, Humans, Male, Cystitis diagnostic imaging, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography methods, Radiopharmaceuticals
- Published
- 2019
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43. 18 F-FDG PET/CT brown fat detection: Differences between adult and pediatric population in a 12 year experience.
- Author
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Bonacina M, Albano D, Gazzilli M, Durmo R, Cerudelli E, Bosio G, Bertagna F, and Giubbini R
- Subjects
- Adipose Tissue, Brown physiology, Adiposity, Adolescent, Adult, Body Mass Index, Child, Comorbidity, Female, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Humans, Hyperglycemia epidemiology, Hyperglycemia physiopathology, Italy, Male, Organ Specificity, Overweight diagnostic imaging, Overweight epidemiology, Overweight physiopathology, Parturition, Radiopharmaceuticals, Retrospective Studies, Seasons, Sex Characteristics, Adipose Tissue, Brown diagnostic imaging, Aging physiology, Cold Temperature, Positron Emission Tomography Computed Tomography methods, Thermogenesis physiology
- Abstract
Purpose: To analyze epidemiological and anthropometric features of patients with brown adipose tissue (BAT) activation detected by fluorine18-fluorodeoxyglucose positron emission tomography/computed tomography (
18 F-FDG PET/CT)., Material and Methods: From 2005 to 2017, 81818 F-FDG PET/CT studies positive for BAT detection were retrospectively included, 742 examinations performed on the adult population and 76 PET/CT on the pediatric population. A Chi-squared test was performed to compare features distribution between the adult and pediatric patients., Results: Adults showed a higher rate of BAT detection in females (79% vs. 61%, P<0.001) and in hyperglycaemic patients (>100mg/dL) (24% vs. 16%, P=0.02), no significant difference was found with regard to overweight patients (BMI>25kg/m2 ) (22% vs. 20%, P=.55). Considering females only, the adults showed a higher rate of BAT detection both in hyperglycaemic (83% vs. 42%, P<0.001) and overweight patients (80% vs. 67%, P=0.005). In both populations BAT activation happened more frequently in cold seasons; there was no significant distribution difference with regard to season of birth (P=0.2)., Conclusions: Sex, glycemia and BMI play a major role in predicting BAT activation, with significant differences between adults and pediatric patients. Cold exposure is confirmed as an important predicting factor, while season of birth is not significant., (Copyright © 2019 Sociedad Española de Medicina Nuclear e Imagen Molecular. Publicado por Elsevier España, S.L.U. All rights reserved.)- Published
- 2019
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44. 68 Ga-PSMA PET thyroid incidentalomas.
- Author
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Bertagna F, Albano D, Giovanella L, Bonacina M, Durmo R, Giubbini R, and Treglia G
- Subjects
- Adenoma epidemiology, Adenoma metabolism, Adenoma pathology, Edetic Acid pharmacokinetics, Gallium Isotopes, Gallium Radioisotopes, Humans, Male, Prostatic Neoplasms diagnosis, Prostatic Neoplasms epidemiology, Prostatic Neoplasms metabolism, Prostatic Neoplasms pathology, Thyroid Neoplasms epidemiology, Thyroid Neoplasms metabolism, Thyroid Neoplasms pathology, Adenoma diagnosis, Edetic Acid analogs & derivatives, Incidental Findings, Oligopeptides pharmacokinetics, Positron Emission Tomography Computed Tomography methods, Thyroid Neoplasms diagnosis
- Abstract
Introduction: Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. The aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled prostate-specific membrane antigen (PSMA) uptake in the thyroid gland [PSMA thyroid incidentaloma (PTI)] revealed by PET/CT or PET/MRI., Methods: A comprehensive literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted to find relevant published articles about the prevalence and clinical significance of PTIs detected by PET/CT or PET/MRI in patients studied for other oncologic purposes., Results: Twelve articles were included in the systematic review. Among 23 PTIs, 6 were malignant (5 primary thyroid tumors and one metastasis from renal cell carcinoma), one was a follicular lesion of undetermined significance, and the rest were benign., Conclusion: Despite being very rare, though probably underestimated, PTIs frequently signal the presence of unexpected lesions in the thyroid which differ from the indicated reason for which the patient was initially scanned and concerning which the risk of malignancy is not negligible.
- Published
- 2019
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45. Radioguided lung lesion localization: introducing a fluoroscopy system in a SPECT/CT scan.
- Author
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Durmo R, Lechiara M, Benetti D, Rodella C, Camoni L, Albano D, Bertagna F, and Giubbini R
- Subjects
- Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, Safety, Surgery, Computer-Assisted adverse effects, Surgery, Computer-Assisted instrumentation, Thoracic Surgery, Video-Assisted, Fluoroscopy, Lung Neoplasms diagnostic imaging, Lung Neoplasms surgery, Single Photon Emission Computed Tomography Computed Tomography, Surgery, Computer-Assisted methods
- Abstract
Purpose: The purpose was to report our experience in the use of radiotracer localization and resection of small, indistinct, or nonpalpable pulmonary lesions. We developed an innovative technique implementing a fluoroscopy system on a single-photon emission computed tomography/computed tomography (SPECT/CT) scan that allowed to perform CT-guided injection of radiotracer directly on SPECT/CT., Patients and Methods: Patients were selected for the radiotracer procedure in presence of difficulties in locating nodules with video-assisted thoracoscopic surgery (VATS). Overall, 0.2 ml of technetium-99m macroaggregated albumin and 0.3 ml of nonionic iodinated contrast were injected under CT guidance. During the VATS procedure, an endoscopic gamma detecting probe was introduced to scan the lung surface. The area of major radioactivity, which matched with the area of the nodule, was resected., Results: Between January 2016 and October 2018, 37 patients underwent CT-guided radiotracer injection. The mean nodule size was 11 mm. CT nodule morphology characteristics were as follows: 15 nodules were ground glass, 12 were solid, and 10 were partly solid. No significant adverse events occurred. In one patient, the surgeons decided for an open thoracotomy after unsuccessfully VATS. Overall, lobectomy was performed in two patients, segmentectomy in one, and wedge resection in 33 patients. No mortality occurred. The pathological diagnosis was 15 (42%) primary lung cancer, eight (22%) metastases, and 13 (36%) benign lesions., Conclusion: Radioguided pulmonary nodule localization is a reliable procedure with a high rate of success, minimal complications, and lower risk of failures, with no associated mortality or significant morbidity. Our SPECT/CT system is the first to benefit from the technological improvement with successfully implementation and application of fluoroscopy to SPECT/CT.
- Published
- 2019
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46. Thyroid metastasis from breast cancer detected by 18F-FDG PET/CT.
- Author
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Durmo R, Albano D, and Giubbini R
- Subjects
- Aged, Carcinoma, Ductal, Breast diagnostic imaging, Female, Fluorodeoxyglucose F18, Humans, Positron Emission Tomography Computed Tomography, Thyroid Neoplasms diagnostic imaging, Breast Neoplasms pathology, Carcinoma, Ductal, Breast secondary, Thyroid Neoplasms secondary
- Published
- 2019
- Full Text
- View/download PDF
47. 18F-choline PET/CT incidental thyroid uptake in patients studied for prostate cancer.
- Author
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Albano D, Durmo R, Bertagna F, and Giubbini R
- Subjects
- Aged, Aged, 80 and over, Humans, Male, Middle Aged, Prostatic Neoplasms diagnostic imaging, Retrospective Studies, Choline analogs & derivatives, Incidental Findings, Thyroid Gland diagnostic imaging
- Abstract
Purpose: Thyroid incidental uptake is defined as a thyroid uptake incidentally detected by imaging examinations performed for non-thyroid disease. The aim of this study was to establish the prevalence and the pathological nature of focal thyroid incidental uptake (FTIU) among patients studied with 18F-choline-PET/CT., Materials and Methods: We retrospectively evaluated 368 patients who performed 18F-choline-PET/CT between June 2016 and August 2018. The PET images were analyzed visually and semi-quantitatively by measuring the maximum standardized uptake value (SUVmax) and the mean SUV (SUVmean) of the thyroid gland and of the FTIU; every focal thyroid uptake deviating from physiological distribution and background was considered FTIU. Final diagnosis of FTIU was obtained by cytological or histological examination after surgery., Results: The average SUVmax and SUVmean of thyroid gland in population were 3 and 1.8. Among 368 patients, FTIU was identified in nine cases (2.4%) and eight underwent further investigations to determine the nature. Two FTIU were classified as malignant (thyroid carcinoma), whereas five were benign (three nodular hyperplasia, one follicular adenoma, one Hurtle cell adenoma) and one indeterminate at cytological examination. In malignant lesions, average SUVmax was 9.6 and 4.5, respectively, while average SUVmean was 5.3 and 2.9, respectively. Average SUVmax and SUVmean of benign lesions were 4.9 and 3.2 and of the indeterminate lesion 5 and 3, respectively., Conclusions: 18F-choline-PET/CT FTIU may be a relevant diagnostic reality, which requires further investigations and affects management, especially considering that, despite being mainly benign, also malignancy is possible.
- Published
- 2019
- Full Text
- View/download PDF
48. Clinical and prognostic role of detection timing of distant metastases in patients with differentiated thyroid cancer.
- Author
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Albano D, Panarotto MB, Durmo R, Rodella C, Bertagna F, and Giubbini R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Metastasis diagnostic imaging, Prevalence, Prognosis, Retrospective Studies, Risk Factors, Survival Analysis, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms epidemiology, Whole Body Imaging, Young Adult, Neoplasm Metastasis diagnosis, Thyroid Neoplasms diagnosis
- Abstract
Purpose: Distant metastases (DM) from DTC occur in 5-25% of cases and are correlated to lower survival; the prognostic significance of the temporal onset of DM is unclear. Our aim was to retrospectively analyze the prevalence of DM and to assess the prognostic role of the timing of manifestation of DM regarding the outcome., Materials and Methods: We included 174 patients (mean age 64 years). According to the time of manifestation, DM were divided in two groups: synchronous DM (SDM, n = 108) defined as metastases present at initial diagnosis and metachronous DM (MDM, n = 66) as diagnosed during follow-up. SDM were further sub grouped in pre-RAIT when diagnosed during pre-surgery work-up (n = 35) and baseline-RAIT when detected by first whole body scan after RAIT (n = 73). Disease-specific survival (DSS) was analyzed using the Kaplan-Meier method., Results: Total RAI activities and number of treatments were significantly higher in MDM, also loss of RAI avidity was more frequent in MDM. Forty-four patients died during follow-up, of which 41 were DTC-related deaths, 5-year and 10-year DSS were 80% and 56%. On univariate analysis MDM had significantly shorter DSS; also histotype and RAI avidity were significant risk factors of impaired survival. On multivariate analysis, only loss of RAI avidity remained as independent negative predictor (p = 0.043). Considering SDM, DSS was significantly shorter in pre-RAIT group than baseline-RAIT (p = 0.004). Instead there was no significant difference between pre-RAIT-SDM and MDM in survival outcome (p = 0.875)., Conclusions: In DTC with DM, loss of RAI uptake has an important role in survival. No significant difference in survival outcome was discovered between SDM and MDM; but, among SDM, pre-RAIT had significant shorter DSS than baseline-RAIT.
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- 2019
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49. Possible delayed diagnosis and treatment of metastatic differentiated thyroid cancer by adopting the 2015 ATA guidelines.
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Albano D, Bertagna F, Bonacina M, Durmo R, Cerudelli E, Gazzilli M, Panarotto MB, Formenti AM, Mazziotti G, Giustina A, and Giubbini R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Neoplasm Metastasis pathology, Retrospective Studies, Risk, Thyroglobulin blood, Thyroid Neoplasms pathology, Thyroid Neoplasms surgery, Thyroidectomy, Whole Body Imaging, Delayed Diagnosis, Iodine Radioisotopes therapeutic use, Neoplasm Metastasis diagnosis, Practice Guidelines as Topic, Thyroid Neoplasms radiotherapy
- Abstract
Objective: According to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim of our study was to retrospectively analyze the prevalence of metastatic disease before and after I-131 and to evaluate the influence of the new ATA guidelines in the management of DTC., Methods: We retrospectively analyzed 140 patients showing distant metastases. All metastases were detected by whole-body scan after I-131 and confirmed by histology and/or other imaging modalities., Results: In 26/140 patients metastases were detected before I-131, while in 114/140 were discovered after I-131. Comparing patients with metastases detected before and after I-131, no differences were demonstrated considering age, sex, histotype, tumor size, multifocality of cancer and metastatic localization. Metastatic DTC discovered before radioiodine had higher thyroglobulin and received a higher radioiodine total activity and number of treatments. Considering patients with distant metastases, according to the 2015 ATA guidelines, 38 patients would have been categorized as high risk, 22 as low risk and 80 as intermediate risk. Among intermediate-risk patients, only in 25 cases (31%) I-131 treatment would have been appropriate according to 2015 ATA recommendations; in the remaining 56 cases (69%), I-131 would not have been recommended., Conclusions: According to the 2015 ATA guidelines, most of metastatic patients would not have been treated after surgery, with the risk of late diagnosis and delayed treatment., (© 2018 European Society of Endocrinology.)
- Published
- 2018
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50. Attenuation correction in myocardial perfusion imaging affects the assessment of infarct size in women with previous inferior infarct.
- Author
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Peli A, Camoni L, Zilioli V, Durmo R, Bonacina M, Bertagna F, Paghera B, and Giubbini R
- Subjects
- Aged, Female, Humans, Inferior Wall Myocardial Infarction pathology, Retrospective Studies, Image Processing, Computer-Assisted, Inferior Wall Myocardial Infarction diagnostic imaging, Myocardial Perfusion Imaging
- Abstract
Background: Myocardial perfusion imaging is a well-established diagnostic tool in patients with known or suspected coronary artery disease. Numerous clinical trials have shown that attenuation correction (AC) in single photon emission computed tomography (SPECT) improves the diagnostic accuracy of myocardial perfusion imaging over non-AC SPECT, differentiating between scar and attenuation artifacts. We have previously shown that attenuation artifacts produce an overestimation of the size of inferior infarcts in the male population. It is assumed that women are less affected by inferior attenuation artifacts than men., Purpose: The aim of this study is to evaluate the role of AC in the assessment of infarct size in female patients with a history of myocardial inferior infarct., Patients and Methods: We studied a population of 66 consecutive women, with a history of previous inferior myocardial infarct, by SPECT/computed tomography (CT) with 370+370 MBq of technetium-99m labeled compounds by a 2-day stress-rest protocol. Both AC and uncorrected gated-SPECT/CT studies were reconstructed after scatter and motion correction by ordered-subset expectation maximization iterative reconstruction and resolution recovery. The coregistration of the transmission and emission scans was verified for all patients; any misalignment was realigned manually. Uncorrected and corrected SPECT images were analyzed by software QPS/QGS package using a 17-segment model. For each segment, perfusion and wall motion were quantified using a five-point score according to the American Society of Nuclear Cardiology guidelines. Summed stress, summed rest score (SRS), and summed difference score of the inferior left ventricle wall (inferior, inferoseptal, inferolateral, and apical inferior segments) were calculated. A linear correlation was used to assess the relationship between perfusion and the regional wall motion score as determined by uncorrected gated-SPECT., Results: The results of quantitative analysis of non-AC and CT-AC SPECT images, respectively, were as follows: summed stress score: 9.47±5.01 and 6.58±4.77% (P<0.001); SRS was 6.05±5.02 and 4.14±4.12% (P<0.001); the summed difference score was 2.92±2.74 and 2.52±2.63% (P=NS), respectively. The correlation between corrected and uncorrected SRS and the regional summed wall motion score of the same segment was R=0.31 versus R=0.34., Conclusion: In the female population, like in men, attenuation artifacts affect the calculation of the infarct size of the inferior wall, with overestimation of the infarct size in uncorrected images. The AC regional perfusion score (SRS) better correlates with the regional wall motion score of the inferior wall in women with previous inferior infarct.
- Published
- 2018
- Full Text
- View/download PDF
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