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4. Colon cancer and cell transformation by clinicalSalmonellastrains are associated with bacterial virulence and intracellular fitness

Author

Stévenin, Virginie, primary, Coipan, Claudia E., additional, Duijster, Janneke W., additional, van Elsland, Daphne M., additional, Voogd, Linda, additional, van Hoek, Angela H.A.M., additional, Wijnands, Lucas M., additional, Jansen, Lennert, additional, Akkermans, Jimmy J.L.L., additional, Neefjes-Borst, Andra, additional, Franz, Eelco, additional, Mughini-Gras, Lapo, additional, and Neefjes, Jacques, additional

Published
2023
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5. Use of Ambulance Dispatch Calls for Surveillance of Severe Acute Respiratory Infections

Author

Monge, Susana, Duijster, Janneke, Kommer, Geert Jan, van de Kassteele, Jan, Donker, Ge. A., Krafft, Thomas, Engelen, Paul, Valk, Jens P., de Waard, Jan, de Nooij, Jan, van der Hoek, Wim, and van Asten, Liselotte

Subjects
Influenza -- Health aspects, Death, Time, Infection, Public health, Respiratory tract diseases, Diseases, Health, World Health Organization
Abstract

Influenza virus infection is associated with severe illness and death and causes a high burden of disease (1). The World Health Organization recommends that countries improve surveillance of severe influenza [...]

Published
2020
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11. Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth

Author

van Elsland, Daphne M, Duijster, Janneke W, Zhang, Jilei, Stévenin, Virginie, Zhang, Yongguo, Zha, Lang, Xia, Yinglin, Franz, Eelco, Sun, Jun, Mughini-Gras, Lapo, Neefjes, Jacques, van Elsland, Daphne M, Duijster, Janneke W, Zhang, Jilei, Stévenin, Virginie, Zhang, Yongguo, Zha, Lang, Xia, Yinglin, Franz, Eelco, Sun, Jun, Mughini-Gras, Lapo, and Neefjes, Jacques

Abstract

During infection, Salmonella hijacks essential host signaling pathways. These molecular manipulations disrupt cellular integrity and may induce oncogenic transformation. Systemic S. Typhi infections are linked to gallbladder cancer, whereas severe non-typhoidal Salmonella (NTS) infections are associated with colon cancer (CC). These diagnosed infections, however, represent only a small fraction of all NTS infections as many infections are mild and go unnoticed. To assess the overall impact of NTS infections, we performed a retrospective serological study on NTS exposure in patients with CC. The magnitude of exposure to NTS, as measured by serum antibody titer, is significantly positively associated with CC. Repetitively infecting mice with low NTS exposure showed similar accelerated tumor growth to that observed after high NTS exposure. At the cellular level, NTS preferably infects (pre-)transformed cells, and each infection round exponentially increases the rate of transformed cells. Thus, repetitive exposure to NTS associates with CC risk and accelerates tumor growth.

Published
2022

12. Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth

Author

IRAS OH Epidemiology Microbial Agents, van Elsland, Daphne M, Duijster, Janneke W, Zhang, Jilei, Stévenin, Virginie, Zhang, Yongguo, Zha, Lang, Xia, Yinglin, Franz, Eelco, Sun, Jun, Mughini-Gras, Lapo, Neefjes, Jacques, IRAS OH Epidemiology Microbial Agents, van Elsland, Daphne M, Duijster, Janneke W, Zhang, Jilei, Stévenin, Virginie, Zhang, Yongguo, Zha, Lang, Xia, Yinglin, Franz, Eelco, Sun, Jun, Mughini-Gras, Lapo, and Neefjes, Jacques

Published
2022

13. Bacterial and Parasitic Pathogens as Risk Factors for Cancers in the Gastrointestinal Tract: A Review of Current Epidemiological Knowledge

Author

Duijster, Janneke W., Franz, Eelco, Neefjes, Jacques, Mughini-gras, Lapo, IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, IRAS OH Epidemiology Microbial Agents, and dIRAS RA-I&I I&I

Subjects
Microbiology (medical), oncogenic potential, parasitic infection, gastrointestinal cancer, bacterial infection, epidemiology, Review, environmental risk factor, Microbiology, QR1-502
Abstract

The oncogenic potential of viral infections is well established and documented for many years already. However, the contribution of (commensal) bacteria and parasites to the development and progression of cancers has only recently gained momentum, resulting in a rapid growth of publications on the topic. Indeed, various bacteria and parasites have been suggested to play a role in the development of gastrointestinal cancer in particular. Therefore, an overview of the current epidemiological knowledge on the association between infections with bacteria and parasites and cancers of the gastrointestinal tract is needed. In this review, we summarized the methodological characteristics and main results of epidemiological studies investigating the association of 10 different bacteria (Bacteroides fragilis, Campylobacter spp., Clostridium spp., Enterococcus faecalis, Escherichia coli, Fusobacterium nucleatum, Porphyromonas gingivalis, non-typhoidal Salmonella, Salmonella Typhi, and Streptococcus spp.) and three parasites (Cryptosporidium spp., Schistosoma spp., and Strongyloides stercoralis) with gastrointestinal cancer. While the large body of studies based on microbiome sequencing provides valuable insights into the relative abundance of different bacterial taxa in cancer patients as compared to individuals with pre-malignant conditions or healthy controls, more research is needed to fulfill Koch’s postulates, possibly making use of follow-up data, to assess the complex role of bacterial and parasitic infections in cancer epidemiology. Studies incorporating follow-up time between detection of the bacterium or parasite and cancer diagnosis remain valuable as these allow for estimation of cause-effect relationships.

Published
2022

14. Occupational exposure and risk of colon cancer: a nationwide registry study with emphasis on occupational exposure to zoonotic gastrointestinal pathogens

Author

Duijster, Janneke, Mughini-Gras, Lapo, Neefjes, Jacques, Franz, Eelco, IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, IRAS OH Epidemiology Microbial Agents, and dIRAS RA-I&I I&I

Subjects
medicine.medical_specialty, Colorectal cancer, Registry study, Population, occupational & industrial medicine, Protective factor, Gastrointestinal pathogens, infectious diseases, Risk Factors, Occupational Exposure, Environmental health, Epidemiology, medicine, Animals, Humans, Registries, Occupations, education, Medicine(all), education.field_of_study, business.industry, Incidence, Incidence (epidemiology), General Medicine, medicine.disease, Occupational Diseases, gastrointestinal tumours, Colonic Neoplasms, Medicine, epidemiology, Occupational exposure, business
Abstract

ObjectivesWhile colon cancer (CC) risk is associated with several lifestyle-related factors, including physical inactivity, smoking and diet, the contribution of occupation to CC morbidity remains largely unclear. Growing evidence indicates that gastrointestinal infections like salmonellosis could contribute to CC development. We performed a nationwide registry study to assess potential associations between occupation (history) and CC, including also those occupations with known increased exposure to gastrointestinal pathogens like Salmonella.MethodsPerson-level occupational data for all residents in The Netherlands were linked to CC diagnosis data. Differences in the incidence of (overall, proximal and distal) CC among occupational sectors and risk groups were tested for significance by calculating standardised incidence ratios (SIRs) with 95% CIs using the general population as reference group. Effects of gender, age, exposure duration and latency were also assessed.ResultsSignificant differences in CC incidence were observed only for a few occupational sectors, including the manufacturing of rubber and plastics, machinery and leather, the printing sector and the information service sector (SIRs 1.06–1.88). No elevated risk of CC was observed among people with increased salmonellosis risk through occupational exposure to live animals, manure or among those working in the sale of animal-derived food products (SIRs 0.93–0.95, 0.81–0.95 and 0.93–1.09 for overall, proximal and distal CC, respectively).ConclusionsThe results of this study suggest that occupation in itself provides a relatively small contribution to CC incidence. This is consistent with previous studies where a similar degree of variation in risk estimates was observed. The lack of an association with the high-risk occupations for salmonellosis might be due to higher levels of physical activity, a known protective factor for CC and other diseases, of people working in the agricultural sector, which might outweigh the potential Salmonella-associated risk of CC.

Published
2021

17. Association between Salmonella infection and colon cancer

Author

Duijster, Janneke W, Hansen, Jørgen V, Franz, Eelco, Neefjes, Jacques J C, Frisch, Morten, Mughini-Gras, Lapo, Ethelberg, Steen, IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, IRAS OH Epidemiology Microbial Agents, and dIRAS RA-I&I I&I

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Salmonella, salmonellosis, Adolescent, Colorectal cancer, Epidemiology, Population, Salmonella infection, medicine.disease_cause, non-typhoidal Salmonella, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, inflammatory bowel disease, Internal medicine, medicine, Humans, Child, education, Aged, Netherlands, Proportional Hazards Models, Aged, 80 and over, Original Paper, education.field_of_study, business.industry, Hazard ratio, Infant, Newborn, Infant, Middle Aged, medicine.disease, Confidence interval, Colon cancer, 030104 developmental biology, Infectious Diseases, Child, Preschool, 030220 oncology & carcinogenesis, Colonic Neoplasms, Salmonella Infections, Female, business, Cohort study
Abstract

Laboratory data increasingly suggest that Salmonella infection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the potential risk of CC associated with salmonellosis in the human population. We conducted a population-based cohort study using four health registries in Denmark. Person-level demographic data of all residents were linked to laboratory-confirmed non-typhoidal salmonellosis and to CC diagnoses in 1994–2016. Hazard ratios (HRs) for CC (overall/proximal/distal) associated with reported salmonellosis were estimated using Cox proportional hazard models. Potential effects of serovar, age, sex, inflammatory bowel disease and follow-up time post-infection were also assessed. We found no increased risk of CC ≥1 year post-infection (HR 0.99; 95% confidence interval (CI) 0.88–1.13). When stratifying by serovar, there was a significantly increased risk of proximal CC ≥1 year post-infection with serovars other than Enteritidis and Typhimurium (HR 1.40; 95% CI 1.03–1.90). CC risk was significantly increased in the first year post-infection (HR 2.08; 95% CI 1.48–2.93). The association between salmonellosis and CC in the first year post-infection can be explained by increased stool testing around the time of CC diagnosis. The association between proximal CC and non-Enteritidis/non-Typhimurium serovars is unclear and warrants further investigation. Overall, this study provides epidemiological evidence that notified Salmonella infections do not contribute significantly to CC risk in the studied population.

Published
2021
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18. Bacterial and Parasitic Pathogens as Risk Factors for Cancers in the Gastrointestinal Tract: A Review of Current Epidemiological Knowledge

Author

Duijster, Janneke W., Franz, Eelco, Neefjes, Jacques, Mughini-gras, Lapo, Duijster, Janneke W., Franz, Eelco, Neefjes, Jacques, and Mughini-gras, Lapo

Abstract

The oncogenic potential of viral infections is well established and documented for many years already. However, the contribution of (commensal) bacteria and parasites to the development and progression of cancers has only recently gained momentum, resulting in a rapid growth of publications on the topic. Indeed, various bacteria and parasites have been suggested to play a role in the development of gastrointestinal cancer in particular. Therefore, an overview of the current epidemiological knowledge on the association between infections with bacteria and parasites and cancers of the gastrointestinal tract is needed. In this review, we summarized the methodological characteristics and main results of epidemiological studies investigating the association of 10 different bacteria (Bacteroides fragilis, Campylobacter spp., Clostridium spp., Enterococcus faecalis, Escherichia coli, Fusobacterium nucleatum, Porphyromonas gingivalis, non-typhoidal Salmonella, Salmonella Typhi, and Streptococcus spp.) and three parasites (Cryptosporidium spp., Schistosoma spp., and Strongyloides stercoralis) with gastrointestinal cancer. While the large body of studies based on microbiome sequencing provides valuable insights into the relative abundance of different bacterial taxa in cancer patients as compared to individuals with pre-malignant conditions or healthy controls, more research is needed to fulfill Koch’s postulates, possibly making use of follow-up data, to assess the complex role of bacterial and parasitic infections in cancer epidemiology. Studies incorporating follow-up time between detection of the bacterium or parasite and cancer diagnosis remain valuable as these allow for estimation of cause-effect relationships.

Published
2021

19. Association between Salmonella infection and colon cancer: a nationwide registry-based cohort study

Author

Duijster, Janneke W, Hansen, Jørgen V, Franz, Eelco, Neefjes, Jacques J C, Frisch, Morten, Mughini-Gras, Lapo, Ethelberg, Steen, Duijster, Janneke W, Hansen, Jørgen V, Franz, Eelco, Neefjes, Jacques J C, Frisch, Morten, Mughini-Gras, Lapo, and Ethelberg, Steen

Abstract

Laboratory data increasingly suggests that Salmonella infection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the potential risk of CC associated with salmonellosis in the human population. We conducted a population-based cohort study using four health registries in Denmark. Person-level demographic data of all residents were linked to laboratory-confirmed non-typhoidal salmonellosis and to CC diagnoses in 1994-2016. Hazard ratios (HRs) for CC (overall/proximal/distal) associated with reported salmonellosis were estimated using Cox proportional hazards models. Potential effects of serovar, age, sex, IBD and follow-up time post-infection were also assessed. We found no increased risk of CC ≥1 year post-infection (HR 0.99; 95%CI:0.88-1.13). When stratifying by serovar, there was a significantly increased risk of proximal CC ≥1 year post-infection with serovars other than Enteritidis and Typhimurium (HR 1.40; 95%CI:1.03-1.90). CC risk was significantly increased in the first year post-infection (HR 2.08; 95%CI:1.48-2.93). The association between salmonellosis and CC in the first year post-infection can be explained by increased stool testing around the time of CC diagnosis. The association between proximal CC and non-Enteritidis/non-Typhimurium serovars is unclear and warrants further investigation. Overall, this study provides epidemiological evidence that notified Salmonella infections do not contribute significantly to CC risk in the studied population.

Published
2021

22. Association between Salmonella infection and colon cancer: a nationwide registry-based cohort study

Author

IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, Duijster, Janneke W, Hansen, Jørgen V, Franz, Eelco, Neefjes, Jacques J C, Frisch, Morten, Mughini-Gras, Lapo, Ethelberg, Steen, IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, Duijster, Janneke W, Hansen, Jørgen V, Franz, Eelco, Neefjes, Jacques J C, Frisch, Morten, Mughini-Gras, Lapo, and Ethelberg, Steen

Published
2021

23. Association between Salmonella infection and colon cancer:a nationwide registry-based cohort study

Author

Duijster, Janneke W., Hansen, Jørgen V., Franz, Eelco, Neefjes, Jacques J. C., Frisch, Morten, Mughini-Gras, Lapo, Ethelberg, Steen, Duijster, Janneke W., Hansen, Jørgen V., Franz, Eelco, Neefjes, Jacques J. C., Frisch, Morten, Mughini-Gras, Lapo, and Ethelberg, Steen

Abstract

Laboratory data increasingly suggest that Salmonella infection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the potential risk of CC associated with salmonellosis in the human population. We conducted a population-based cohort study using four health registries in Denmark. Person-level demographic data of all residents were linked to laboratory-confirmed non-typhoidal salmonellosis and to CC diagnoses in 1994-2016. Hazard ratios (HRs) for CC (overall/proximal/distal) associated with reported salmonellosis were estimated using Cox proportional hazard models. Potential effects of serovar, age, sex, inflammatory bowel disease and follow-up time post-infection were also assessed. We found no increased risk of CC >= 1 year post-infection (HR 0.99; 95% confidence interval (CI) 0.88-1.13). When stratifying by serovar, there was a significantly increased risk of proximal CC >= 1 year post-infection with serovars other than Enteritidis and Typhimurium (HR 1.40; 95% CI 1.03-1.90). CC risk was significantly increased in the first year post-infection (HR 2.08; 95% CI 1.48-2.93). The association between salmonellosis and CC in the first year post-infection can be explained by increased stool testing around the time of CC diagnosis. The association between proximal CC and non-Enteritidis/non-Typhimurium serovars is unclear and warrants further investigation. Overall, this study provides epidemiological evidence that notified Salmonella infections do not contribute significantly to CC risk in the studied population.

Published
2021

24. Severe spp. or spp. Infection and the Risk of Biliary Tract Cancer: A Population-Based Study

Author

de Savornin Lohman, Elise, Duijster, Janneke, Groot Koerkamp, Bas, van der Post, Rachel, Franz, Eelco, Mughini Gras, Lapo, and de Reuver, Philip

Subjects
risk factor, bacterial infection, cancer, epidemiology
Abstract

Salmonella spp. infection has shown to have oncogenic transformative effects and thereby increases the risk of certain cancers. For Campylobacter spp., similar effects have been demonstrated. Risk factor identification may allow for timely diagnosis and preventive treatment. To substantiate the oncogenic potential of Salmonella and Campylobacter spp., this study compared the incidence of extrahepatic biliary tract cancer (BTC) in patients with diagnosed Salmonella or Campylobacter spp. infection with BTC incidence in the Netherlands. National infectious diseases surveillance records of patients diagnosed with a laboratory-confirmed Salmonella or Campylobacter spp. infection during 1999-2016 were linked to the Netherlands Cancer Registry. Incidence of BTC in Salmonella and Campylobacter spp. patients was compared to the incidence of BTC in the general population using Standardized Incidence Ratios (SIRs). In total, 16,252 patients were diagnosed with Salmonella spp. and 27,668 with Campylobacter spp. infection. Nine patients developed BTC at a median of 46 months (13-67) after Salmonella spp. infection and seven at a median of 60 months (18-138) after Campylobacter spp. infection. SIR of BTC in salmonellosis patients was 1.53 (95% CI 0.70-2.91). In patients aged

Published
2020

25. Severe Salmonella spp. or Campylobacter spp. Infection and the Risk of Biliary Tract Cancer: A Population-Based Study

Author

de Savornin Lohman, Elise, Duijster, Janneke, Groot Koerkamp, Bas, van der Post, Rachel, Franz, Eelco, Mughini Gras, Lapo, de Reuver, Philip, IRAS OH Epidemiology Microbial Agents, and dIRAS RA-I&I I&I

Subjects
risk factor, bacterial infection, cancer, epidemiology
Abstract

Salmonella spp. infection has shown to have oncogenic transformative effects and thereby increases the risk of certain cancers. For Campylobacter spp., similar effects have been demonstrated. Risk factor identification may allow for timely diagnosis and preventive treatment. To substantiate the oncogenic potential of Salmonella and Campylobacter spp., this study compared the incidence of extrahepatic biliary tract cancer (BTC) in patients with diagnosed Salmonella or Campylobacter spp. infection with BTC incidence in the Netherlands. National infectious diseases surveillance records of patients diagnosed with a laboratory-confirmed Salmonella or Campylobacter spp. infection during 1999-2016 were linked to the Netherlands Cancer Registry. Incidence of BTC in Salmonella and Campylobacter spp. patients was compared to the incidence of BTC in the general population using Standardized Incidence Ratios (SIRs). In total, 16,252 patients were diagnosed with Salmonella spp. and 27,668 with Campylobacter spp. infection. Nine patients developed BTC at a median of 46 months (13-67) after Salmonella spp. infection and seven at a median of 60 months (18-138) after Campylobacter spp. infection. SIR of BTC in salmonellosis patients was 1.53 (95% CI 0.70-2.91). In patients aged

Published
2020

26. Severe salmonella spp. or campylobacter spp. infection and the risk of biliary tract cancer

Author

de Savornin Lohman, Elise, Duijster, Janneke, Groot Koerkamp, Bas, van der Post, Rachel, Franz, Eelco, Mughini Gras, Lapo, de Reuver, Philip, IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, Surgery, and Gastroenterology & Hepatology

Subjects
Cancer Research, Salmonella, medicine.medical_specialty, Population, Campylobacteriosis, medicine.disease_cause, Gastroenterology, lcsh:RC254-282, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], medicine, cancer, Risk factor, education, education.field_of_study, business.industry, Campylobacter, Incidence (epidemiology), bacterial infection, Cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer registry, Oncology, risk factor, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, epidemiology, business
Abstract

Salmonella spp. infection has shown to have oncogenic transformative effects and thereby increases the risk of certain cancers. For Campylobacter spp., similar effects have been demonstrated. Risk factor identification may allow for timely diagnosis and preventive treatment. To substantiate the oncogenic potential of Salmonella and Campylobacter spp., this study compared the incidence of extrahepatic biliary tract cancer (BTC) in patients with diagnosed Salmonella or Campylobacter spp. infection with BTC incidence in the Netherlands. National infectious diseases surveillance records of patients diagnosed with a laboratory-confirmed Salmonella or Campylobacter spp. infection during 1999&ndash, 2016 were linked to the Netherlands Cancer Registry. Incidence of BTC in Salmonella and Campylobacter spp. patients was compared to the incidence of BTC in the general population using Standardized Incidence Ratios (SIRs). In total, 16,252 patients were diagnosed with Salmonella spp. and 27,668 with Campylobacter spp. infection. Nine patients developed BTC at a median of 46 months (13&ndash, 67) after Salmonella spp. infection and seven at a median of 60 months (18&ndash, 138) after Campylobacter spp. infection. SIR of BTC in salmonellosis patients was 1.53 (95% CI 0.70&ndash, 2.91). In patients aged &lt, 60 years, the SIR was 1.74 (95% CI 0.36&ndash, 5.04). For campylobacteriosis patients, the SIR was 0.97 (95% CI 0.39&ndash, 2.00). Even though Salmonella or Campylobacter spp. infection was not significantly associated with increased BTC risk in this cohort, it remains extremely important to study potential risk factors for cancer to facilitate screening and ultimately improve prognosis of cancer patients.

Published
2020

27. Severe Salmonella spp. or Campylobacter spp. Infection and the Risk of Biliary Tract Cancer: A Population-Based Study

Author

Savornin Lohman, E.A.J. de, Duijster, Janneke, Groot Koerkamp, Bas, Post, R.S. van der, Franz, Eelco, Mughini Gras, Lapo, Reuver, P.R. de, Savornin Lohman, E.A.J. de, Duijster, Janneke, Groot Koerkamp, Bas, Post, R.S. van der, Franz, Eelco, Mughini Gras, Lapo, and Reuver, P.R. de

Abstract

Contains fulltext : 228456.pdf (publisher's version ) (Open Access)

Published
2020

28. Severe Salmonella spp. or Campylobacter spp. Infection and the Risk of Biliary Tract Cancer: A Population-Based Study

Author

IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, de Savornin Lohman, Elise, Duijster, Janneke, Groot Koerkamp, Bas, van der Post, Rachel, Franz, Eelco, Mughini Gras, Lapo, de Reuver, Philip, IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I I&I, de Savornin Lohman, Elise, Duijster, Janneke, Groot Koerkamp, Bas, van der Post, Rachel, Franz, Eelco, Mughini Gras, Lapo, and de Reuver, Philip

Published
2020

29. Utility of emergency call centre, dispatch and ambulance data for syndromic surveillance of infectious diseases: a scoping review

Author

Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Duijster, Janneke W, Doreleijers, Simone DA, Pilot, Eva, van der Hoek, Wim, Kommer, Geert Jan, van der Sande, Marianne Ab, Krafft, Thomas, van Asten, Liselotte Chi, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Duijster, Janneke W, Doreleijers, Simone DA, Pilot, Eva, van der Hoek, Wim, Kommer, Geert Jan, van der Sande, Marianne Ab, Krafft, Thomas, and van Asten, Liselotte Chi

Published
2020

31. Ambulance dispatch calls attributable to influenza A and other common respiratory viruses in the Netherlands (2014‐2016)

Author

Monge, Susana, primary, Duijster, Janneke, additional, Kommer, Geert Jan, additional, Kassteele, Jan, additional, Krafft, Thomas, additional, Engelen, Paul, additional, Valk, Jens P., additional, Waard, Jan, additional, Nooij, Jan, additional, Riezebos‐Brilman, Annelies, additional, Hoek, Wim, additional, and Asten, Liselotte, additional

Published
2020
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33. Malaria in Eritrean migrants newly arrived in seven European countries, 2011 to 2016

Author

Sondén, Klara, Rolling, Thierry, Wångdahl, Andreas, Ydring, Elsie, Vygen-Bonnet, Sabine, Kobbe, Robert, Douhan, Johan, Hammar, Ulf, Duijster, Janneke, de Gier, Brechje, Freedman, Joanne, Gysin, Nicole, Stark, Klaus, Stevens, Flora, Vestergaard, Lasse Skafte, Tegnell, Anders, and Färnert, Anna

Subjects
relapse, outbreak, travellers, malaria, plasmodium vivax, migrants
Abstract

Global migration has resulted in a large number of asylum applications in Europe. In 2014, clusters of

Published
2019

34. Changing epidemiology of invasive non-typhoid Salmonella infection: a nationwide population-based registry study

Author

Mughini-Gras, Lapo, Pijnacker, Roan, Duijster, Janneke, Heck, Max, Wit, Ben, Veldman, Kees, Franz, Eelco, Mughini-Gras, Lapo, Pijnacker, Roan, Duijster, Janneke, Heck, Max, Wit, Ben, Veldman, Kees, and Franz, Eelco

Abstract

OBJECTIVES: Non-typhoid Salmonella (NTS) may invade beyond the intestine, causing bacteraemia, sepsis, and infection of normally sterile sites. The epidemiology of invasive NTS (iNTS) infection is under-researched. We determined trends, risk factors, serotype distribution, antimicrobial resistance (AMR), and attributable sources of iNTS infection in a high-income setting.METHODS: 22,837 records of culture-confirmed human salmonellosis cases and 10,008 serotyped Salmonella isolates from five putative animal reservoirs (pigs, cattle, broilers, layers, reptiles) in the Netherlands during 2005-2018 were retrieved from national surveillance registries. Risk factors for iNTS infection were identified using logistic regression analysis. Source attribution modelling was based on serotyping, prevalence, and exposure data.RESULTS: The average annual percentage of iNTS infections was 4.6% (range: 3.5-5.7%). An increase in iNTS infections was observed since 2012 (Odds Ratio [OR]: 1.09, 95% Confidence Interval [95%CI]: 1.04-1.14). Increased iNTS infection risk was associated with wintertime (OR: 1.37, 95%CI: 1.12-1.66), male sex (OR: 1.73, 95%CI: 1.51-1.99), older age (ORs: 3.27 to 16.33, depending on age groups), and living in rural areas (OR: 1.54, 95%CI: 1.23-1.93). While 52% of iNTS infections (n=950) were caused by serotypes Enteritidis and Typhimurium, those displaying the highest invasiveness relative to their occurrence were Dublin (32.9%, n=163), Panama (21.6%, n=106), and Poona (14.1%, n=71). Cattle were a larger source of iNTS than non-iNTS infections (12.2% vs. 7.6%). Lower AMR and multi-resistance rates were observed among iNTS (37.9%) than non-iNTS isolates (48.6%).CONCLUSIONS: The increase in iNTS infections, which is reported also in other countries, is of public health and clinical concern. The underlying reasons seem to be multi-factorial in nature. iNTS infection risk depends more on the infecting serotypes and patient demographics, and

Published
2019

36. Association between infection and colon cancer: a nationwide registry-based cohort study.

Author

Duijster, Janneke W., Hansen, Jørgen V., Franz, Eelco, Neefjes, Jacques J. C., Frisch, Morten, Mughini-Gras, Lapo, and Ethelberg, Steen

Abstract

Laboratory data increasingly suggest that Salmonella infection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the potential risk of CC associated with salmonellosis in the human population. We conducted a population-based cohort study using four health registries in Denmark. Person-level demographic data of all residents were linked to laboratory-confirmed non-typhoidal salmonellosis and to CC diagnoses in 1994-2016. Hazard ratios (HRs) for CC (overall/proximal/distal) associated with reported salmonellosis were estimated using Cox proportional hazard models. Potential effects of serovar, age, sex, inflammatory bowel disease and follow-up time post-infection were also assessed. We found no increased risk of CC ≥1 year post-infection (HR 0.99; 95% confidence interval (CI) 0.88-1.13). When stratifying by serovar, there was a significantly increased risk of proximal CC ≥1 year post-infection with serovars other than Enteritidis and Typhimurium (HR 1.40; 95% CI 1.03-1.90). CC risk was significantly increased in the first year post-infection (HR 2.08; 95% CI 1.48-2.93). The association between salmonellosis and CC in the first year post-infection can be explained by increased stool testing around the time of CC diagnosis. The association between proximal CC and non-Enteritidis/non-Typhimurium serovars is unclear and warrants further investigation. Overall, this study provides epidemiological evidence that notified Salmonella infections do not contribute significantly to CC risk in the studied population. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Malaria in Eritrean migrants newly arrived in seven European countries, 2011 to 2016

Author

Sondén, Klara, primary, Rolling, Thierry, additional, Wångdahl, Andreas, additional, Ydring, Elsie, additional, Vygen-Bonnet, Sabine, additional, Kobbe, Robert, additional, Douhan, Johan, additional, Hammar, Ulf, additional, Duijster, Janneke, additional, de Gier, Brechje, additional, Freedman, Joanne, additional, Gysin, Nicole, additional, Stark, Klaus, additional, Stevens, Flora, additional, Vestergaard, Lasse Skafte, additional, Tegnell, Anders, additional, and Färnert, Anna, additional

Published
2019
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40. Utility of emergency call centre, dispatch and ambulance data for syndromic surveillance of infectious diseases: a scoping review.

Author

Duijster, Janneke W, Doreleijers, Simone D A, Pilot, Eva, van der Hoek, Wim, Kommer, Geert Jan, Sande, Marianne A B van der, Krafft, Thomas, and Asten, Liselotte C H I van

Subjects
*AMBULANCES, *COMMUNICABLE diseases, *DOCUMENTATION, *EMERGENCY medical services, *LUNG diseases, *MEDICAL quality control, *MEDICAL care use, *PUBLIC health surveillance, *SYSTEMATIC reviews, *LITERATURE reviews
Abstract

Background Syndromic surveillance can supplement conventional health surveillance by analyzing less-specific, near-real-time data for an indication of disease occurrence. Emergency medical call centre dispatch and ambulance data are examples of routinely and efficiently collected syndromic data that might assist in infectious disease surveillance. Scientific literature on the subject is scarce and an overview of results is lacking. Methods A scoping review including (i) review of the peer-reviewed literature, (ii) review of grey literature and (iii) interviews with key informants. Results Forty-four records were selected: 20 peer reviewed and 24 grey publications describing 44 studies and systems. Most publications focused on detecting respiratory illnesses or on outbreak detection at mass gatherings. Most used retrospective data; some described outcomes of temporary systems; only two described continuously active dispatch- and ambulance-based syndromic surveillance. Key informants interviewed valued dispatch- and ambulance-based syndromic surveillance as a potentially useful addition to infectious disease surveillance. Perceived benefits were its potential timeliness, standardization of data and clinical value of the data. Conclusions Various dispatch- and ambulance-based syndromic surveillance systems for infectious diseases have been reported, although only roughly half are documented in peer-reviewed literature and most concerned retrospective research instead of continuously active surveillance systems. Dispatch- and ambulance-based syndromic data were mostly assessed in relation to respiratory illnesses; reported use for other infectious disease syndromes is limited. They are perceived by experts in the field of emergency surveillance to achieve time gains in detection of infectious disease outbreaks and to provide a useful addition to traditional surveillance efforts. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Repetitive non-typhoidal Salmonellaexposure is an environmental risk factor for colon cancer and tumor growth

Author

van Elsland, Daphne M., Duijster, Janneke W., Zhang, Jilei, Stévenin, Virginie, Zhang, Yongguo, Zha, Lang, Xia, Yinglin, Franz, Eelco, Sun, Jun, Mughini-Gras, Lapo, and Neefjes, Jacques

Abstract

During infection, Salmonellahijacks essential host signaling pathways. These molecular manipulations disrupt cellular integrity and may induce oncogenic transformation. Systemic S.Typhi infections are linked to gallbladder cancer, whereas severe non-typhoidal Salmonella(NTS) infections are associated with colon cancer (CC). These diagnosed infections, however, represent only a small fraction of all NTS infections as many infections are mild and go unnoticed. To assess the overall impact of NTS infections, we performed a retrospective serological study on NTS exposure in patients with CC. The magnitude of exposure to NTS, as measured by serum antibody titer, is significantly positively associated with CC. Repetitively infecting mice with low NTS exposure showed similar accelerated tumor growth to that observed after high NTS exposure. At the cellular level, NTS preferably infects (pre-)transformed cells, and each infection round exponentially increases the rate of transformed cells. Thus, repetitive exposure to NTS associates with CC risk and accelerates tumor growth.

Published
2022
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42. [West Nile virus unexpectedly in the Netherlands].

Author

Braks MAH, Duijster JW, and Stroo CAJ

Subjects
Animals, Birds, Humans, Netherlands epidemiology, Culicidae, West Nile Fever epidemiology, West Nile Fever veterinary, West Nile virus
Abstract

West Nile virus (WNV) was first detected in birds, mosquitoes and subsequently in humans in the Netherlands in 2020. In 2016 , we had discussed the factors that influence the introduction, establishment and dissemination of WNV in the Netherlands and considered the probability that each of these three phases could occur in the Netherlands, and cause West Nile fever in humans, still relatively small. In the current article we evaluate on the basis of our reasoning at the time, whether we have missed important factors and/or whether new factors have appeared on the horizon. We then explain what the findings/ this progressive insight of 2020 mean for the near future.

Published
2022

43. Occupational exposure and risk of colon cancer: a nationwide registry study with emphasis on occupational exposure to zoonotic gastrointestinal pathogens.

Author

Duijster J, Mughini-Gras L, Neefjes J, and Franz E

Subjects
Animals, Humans, Incidence, Occupations, Registries, Risk Factors, Colonic Neoplasms epidemiology, Colonic Neoplasms etiology, Occupational Diseases epidemiology, Occupational Diseases etiology, Occupational Exposure adverse effects
Abstract

Objectives: While colon cancer (CC) risk is associated with several lifestyle-related factors, including physical inactivity, smoking and diet, the contribution of occupation to CC morbidity remains largely unclear. Growing evidence indicates that gastrointestinal infections like salmonellosis could contribute to CC development. We performed a nationwide registry study to assess potential associations between occupation (history) and CC, including also those occupations with known increased exposure to gastrointestinal pathogens like Salmonella. METHODS: Person-level occupational data for all residents in The Netherlands were linked to CC diagnosis data. Differences in the incidence of (overall, proximal and distal) CC among occupational sectors and risk groups were tested for significance by calculating standardised incidence ratios (SIRs) with 95% CIs using the general population as reference group. Effects of gender, age, exposure duration and latency were also assessed., Results: Significant differences in CC incidence were observed only for a few occupational sectors, including the manufacturing of rubber and plastics, machinery and leather, the printing sector and the information service sector (SIRs 1.06-1.88). No elevated risk of CC was observed among people with increased salmonellosis risk through occupational exposure to live animals, manure or among those working in the sale of animal-derived food products (SIRs 0.93-0.95, 0.81-0.95 and 0.93-1.09 for overall, proximal and distal CC, respectively)., Conclusions: The results of this study suggest that occupation in itself provides a relatively small contribution to CC incidence. This is consistent with previous studies where a similar degree of variation in risk estimates was observed. The lack of an association with the high-risk occupations for salmonellosis might be due to higher levels of physical activity, a known protective factor for CC and other diseases, of people working in the agricultural sector, which might outweigh the potential Salmonella -associated risk of CC., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2021
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44. Severe Salmonella spp. or Campylobacter spp. Infection and the Risk of Biliary Tract Cancer: A Population-Based Study.

Author

de Savornin Lohman E, Duijster J, Groot Koerkamp B, van der Post R, Franz E, Mughini Gras L, and de Reuver P

Abstract

Salmonella spp. infection has shown to have oncogenic transformative effects and thereby increases the risk of certain cancers. For Campylobacter spp., similar effects have been demonstrated. Risk factor identification may allow for timely diagnosis and preventive treatment. To substantiate the oncogenic potential of Salmonella and Campylobacter spp., this study compared the incidence of extrahepatic biliary tract cancer (BTC) in patients with diagnosed Salmonella or Campylobacter spp. infection with BTC incidence in the Netherlands. National infectious diseases surveillance records of patients diagnosed with a laboratory-confirmed Salmonella or Campylobacter spp. infection during 1999-2016 were linked to the Netherlands Cancer Registry. Incidence of BTC in Salmonella and Campylobacter spp. patients was compared to the incidence of BTC in the general population using Standardized Incidence Ratios (SIRs). In total, 16,252 patients were diagnosed with Salmonella spp. and 27,668 with Campylobacter spp. infection. Nine patients developed BTC at a median of 46 months (13-67) after Salmonella spp. infection and seven at a median of 60 months (18-138) after Campylobacter spp. infection. SIR of BTC in salmonellosis patients was 1.53 (95% CI 0.70-2.91). In patients aged <60 years, the SIR was 1.74 (95% CI 0.36-5.04). For campylobacteriosis patients, the SIR was 0.97 (95% CI 0.39-2.00). Even though Salmonella or Campylobacter spp. infection was not significantly associated with increased BTC risk in this cohort, it remains extremely important to study potential risk factors for cancer to facilitate screening and ultimately improve prognosis of cancer patients.

Published
2020
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45. [Birds, mosquitoes and West Nile virus: little risk of West Nile fever in the Netherlands].

Author

Duijster JW, Stroo CJ, and Braks MA

Subjects
Animals, Birds virology, Culicidae virology, Disease Reservoirs virology, Europe epidemiology, Humans, Insect Vectors growth & development, Netherlands epidemiology, Risk, West Nile Fever transmission, West Nile virus, Disease Reservoirs veterinary, Insect Vectors virology, West Nile Fever epidemiology
Abstract

Due to increased incidence of West Nile fever (WNF) in Europe and the rapid spread of West Nile virus (WNV) in the US, it is commonly thought that it will only be a matter of time before WNV reaches the Netherlands. However, assessing whether WNV is really a threat to the Dutch population is challenging, due to the numerous factors affecting transmission of the virus. Some of these factors are known to limit the risk of WNF in the Netherlands. This risk is determined by the interaction between the pathogen (WNV), the vectors (Culex mosquitoes), the reservoirs (birds) and the exposure of humans to infected mosquitoes. In this paper, we discuss the factors influencing introduction, establishment and spread of WNV in the Netherlands. The probability that each of these three phases will occur in the Netherlands is currently relatively small, as is the risk of WNF infection in humans in the Netherlands.

Published
2016

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