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Occupational exposure and risk of colon cancer: a nationwide registry study with emphasis on occupational exposure to zoonotic gastrointestinal pathogens
- Source :
- BMJ Open, 11(8), 1. BMJ Publishing Group Ltd, BMJ Open, BMJ Open, 11(8). BMJ PUBLISHING GROUP, BMJ Open, Vol 11, Iss 8 (2021)
- Publication Year :
- 2021
-
Abstract
- ObjectivesWhile colon cancer (CC) risk is associated with several lifestyle-related factors, including physical inactivity, smoking and diet, the contribution of occupation to CC morbidity remains largely unclear. Growing evidence indicates that gastrointestinal infections like salmonellosis could contribute to CC development. We performed a nationwide registry study to assess potential associations between occupation (history) and CC, including also those occupations with known increased exposure to gastrointestinal pathogens like Salmonella.MethodsPerson-level occupational data for all residents in The Netherlands were linked to CC diagnosis data. Differences in the incidence of (overall, proximal and distal) CC among occupational sectors and risk groups were tested for significance by calculating standardised incidence ratios (SIRs) with 95% CIs using the general population as reference group. Effects of gender, age, exposure duration and latency were also assessed.ResultsSignificant differences in CC incidence were observed only for a few occupational sectors, including the manufacturing of rubber and plastics, machinery and leather, the printing sector and the information service sector (SIRs 1.06–1.88). No elevated risk of CC was observed among people with increased salmonellosis risk through occupational exposure to live animals, manure or among those working in the sale of animal-derived food products (SIRs 0.93–0.95, 0.81–0.95 and 0.93–1.09 for overall, proximal and distal CC, respectively).ConclusionsThe results of this study suggest that occupation in itself provides a relatively small contribution to CC incidence. This is consistent with previous studies where a similar degree of variation in risk estimates was observed. The lack of an association with the high-risk occupations for salmonellosis might be due to higher levels of physical activity, a known protective factor for CC and other diseases, of people working in the agricultural sector, which might outweigh the potential Salmonella-associated risk of CC.
- Subjects :
- medicine.medical_specialty
Colorectal cancer
Registry study
Population
occupational & industrial medicine
Protective factor
Gastrointestinal pathogens
infectious diseases
Risk Factors
Occupational Exposure
Environmental health
Epidemiology
medicine
Animals
Humans
Registries
Occupations
education
Medicine(all)
education.field_of_study
business.industry
Incidence
Incidence (epidemiology)
General Medicine
medicine.disease
Occupational Diseases
gastrointestinal tumours
Colonic Neoplasms
Medicine
epidemiology
Occupational exposure
business
Subjects
Details
- Language :
- English
- ISSN :
- 20446055
- Database :
- OpenAIRE
- Journal :
- BMJ Open, 11(8), 1. BMJ Publishing Group Ltd, BMJ Open, BMJ Open, 11(8). BMJ PUBLISHING GROUP, BMJ Open, Vol 11, Iss 8 (2021)
- Accession number :
- edsair.doi.dedup.....f522803876bb4c276e3988c7cf871a1c