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3. Efficient orbital imaging based on ultrafast momentum microscopy and sparsity-driven phase retrieval

Author

Jansen, G. S. M., Keunecke, M., Düvel, M., Möller, C., Schmitt, D., Bennecke, W., Kappert, F. J. S., Steil, D., Luke, D. R., Steil, S., and Mathias, S.

Subjects
Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract

We present energy-resolved photoelectron momentum maps for orbital tomography that have been collected with a novel and efficient time-of-flight momentum microscopy setup. This setup is combined with a 0.5 MHz table-top femtosecond extreme-ultraviolet light source, which enables unprecedented speed in data collection and paves the way towards time-resolved orbital imaging experiments in the future. Moreover, we take a significant step forward in the data analysis procedure for orbital imaging, and present a sparsity-driven approach to the required phase retrieval problem, which uses only the number of non-zero pixels in the orbital. Here, no knowledge of the object support is required, and the sparsity number can easily be determined from the measured data. Used in the relaxed averaged alternating reflections algorithm, this sparsity constraint enables fast and reliable phase retrieval for our experimental as well as noise-free and noisy simulated photoelectron momentum map data.

Published
2020
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11. Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders.

Author

Rynn, Caroline and Duevel, Heide Marika

Subjects
*SMALL molecules, *MACHINE learning, *DRUG discovery, *STRUCTURE-activity relationships, *BLOOD proteins, *PROTEOLYSIS
Abstract

The article discusses a meeting report on DMPK optimization strategies and quantitative translational PKPD frameworks for predicting human PK and efficacious dose of targeted protein degraders. Targeted protein degradation (TPD) is a novel therapeutic modality that has expanded the druggable proteome for cancer treatment. The meeting brought together experts to discuss challenges and opportunities in DMPK and PKPD optimization for TPDs, with presentations covering physicochemical attributes, DMPK screening optimization, PBPK modeling, quantitative PKPD modeling, and in vitro-in vivo extrapolation of PROTAC clearance. The attendees appreciated the content of the presentations and the interactive Q&A session, leading to plans for a second meeting in 2026 to further advance the field of DMPK/PD science of TPDs. [Extracted from the article]

Published
2024
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13. Considering the societal perspective in economic evaluations: a systematic review in the case of depression

Author

Juliane Andrea Duevel, Lena Hasemann, Luz María Peña-Longobardo, Beatriz Rodríguez-Sánchez, Isaac Aranda-Reneo, Juan Oliva-Moreno, Julio López-Bastida, and Wolfgang Greiner

Subjects
Cost-utility analysis, CUA, Quality-adjusted life years, QALY, Societal perspective, Incremental cost-utility ratio, Medicine (General), R5-920
Abstract

Abstract Background Depressive disorders are associated with a high burden of disease. However, due to the burden posed by the disease on not only the sufferers, but also on their relatives, there is an ongoing debate about which costs to include and, hence, which perspective should be applied. Therefore, the aim of this paper was to examine whether the change between healthcare payer and societal perspective leads to different conclusions of cost-utility analyses in the case of depression. Methods A systematic literature search was conducted to identify economic evaluations of interventions in depression, launched on Medline and the Cost-Effectiveness Registry of the Tufts University using a ten-year time horizon (2008–2018). In a two-stepped screening process, cost-utility studies were selected by means of specified inclusion and exclusion criteria. Subsequently, relevant findings was extracted and, if not fully stated, calculated by the authors of this work. Results Overall, 53 articles with 92 complete economic evaluations, reporting costs from healthcare payer/provider and societal perspective, were identified. More precisely, 22 estimations (24%) changed their results regarding the cost-effectiveness quadrant when the societal perspective was included. Furthermore, 5% of the ICURs resulted in cost-effectiveness regarding the chosen threshold (2% of them became dominant) when societal costs were included. However, another four estimations (4%) showed the opposite result: these interventions were no longer cost-effective after the inclusion of societal costs. Conclusions Summarising the disparities in results and applied methods, the results show that societal costs might alter the conclusions in cost-utility analyses. Hence, the relevance of the perspectives chosen should be taken into account when carrying out an economic evaluation. This systematic review demonstrates that the results of economic evaluations can be affected by different methods available for estimating non-healthcare costs.

Published
2020
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22. Methodisches Vorgehen

Author

Düvel, Caroline, Hepp, Andreas, Series editor, Krotz, Friedrich, Series editor, Vogelgesang, Waldemar, Series editor, Hartmann, Maren, Series editor, and Düvel, Caroline

Published
2016
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29. Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders

Author

Volak, Laurie P., primary, Duevel, Heide Marika, additional, Humphreys, Sara, additional, Nettleton, David, additional, Phipps, Colin, additional, Pike, Andy, additional, Rynn, Caroline, additional, Scott-Stevens, Paul, additional, Zhang, Donglu, additional, and Zientek, Michael, additional

Published
2023
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40. Start von AutoCAD 14

Author

Apel, Fred, Düvel, Holger, Galow, Uwe, Apel, Fred, Düvel, Holger, Galow, Uwe, and Reinemann, Günter, editor

Published
1998
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42. Der 2D-Modellierer

Author

Apel, Fred, Düvel, Holger, Galow, Uwe, Apel, Fred, Düvel, Holger, Galow, Uwe, and Reinemann, Günter, editor

Published
1998
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