Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders.

The article discusses a meeting report on DMPK optimization strategies and quantitative translational PKPD frameworks for predicting human PK and efficacious dose of targeted protein degraders. Targeted protein degradation (TPD) is a novel therapeutic modality that has expanded the druggable proteome for cancer treatment. The meeting brought together experts to discuss challenges and opportunities in DMPK and PKPD optimization for TPDs, with presentations covering physicochemical attributes, DMPK screening optimization, PBPK modeling, quantitative PKPD modeling, and in vitro-in vivo extrapolation of PROTAC clearance. The attendees appreciated the content of the presentations and the interactive Q&A session, leading to plans for a second meeting in 2026 to further advance the field of DMPK/PD science of TPDs. [Extracted from the article]