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291 results on '"Dubreil Laurence"'

1. Functionality of lipids and lipid-protein interactions in cereal-derived food products

Author

Marion Didier, Dubreil Laurence, and Douliez Jean-Paul

Subjects
Céréales, lipides, panification, blé, orge, brasserie, puroindolines, protéines de transfert de lipides, interactions lipide-protéine, Oils, fats, and waxes, TP670-699
Abstract

Lipids and especially cereal lipids play a significant role in the processing and quality of cereals and baked cereal foods (bread, biscuits) and beverages (beer). Most of the physico-chemical mechanisms responsible for the lipid functionality has been investigated and recently the specific role of lipid-binding proteins, e.g. lipid transfer proteins and puroindolines, has been highlighted. The state of the researches performed in this field are briefly presented in this review and the data obtained until now show that new perspectives are opened in cereal breeding and processing for improving the quality of cereals and cereal products.

Published
2003
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4. Goat uterine epithelial cells are susceptible to infection with Caprine Arthritis Encephalitis Virus (CAEV) in vivo

Author

Ali Al Ahmad Mohamad Z, Dubreil Laurence, Chatagnon Gérard, Khayli Zakaria, Theret Marine, Martignat Lionel, Chebloune Yahia, and Fieni Francis

Subjects
Veterinary medicine, SF600-1100
Abstract

ABSTRACT The aim of this study was to determine, using immunofluorescence and in situ hybridization, whether CAEV is capable of infecting goat uterine epithelial cells in vivo. Five CAEV seropositive goats confirmed as infected using double nested polymerase chain reaction (dnPCR) on leucocytes and on vaginal secretions were used as CAEV positive goats. Five CAEV-free goats were used as controls. Samples from the uterine horn were prepared for dnPCR, in situ hybridization, and immunofluorescence. The results from dnPCR confirmed the presence of CAEV proviral DNA in the uterine horn samples of infected goats whereas no CAEV proviral DNA was detected in samples taken from the uninfected control goats. The in situ hybridization probe was complementary to part of the CAEV gag gene and confirmed the presence of CAEV nucleic acids in uterine samples. The positively staining cells were seen concentrated in the mucosa of the lamina propria of uterine sections. Finally, laser confocal analysis of double p28/cytokeratin immunolabelled transverse sections of CAEV infected goat uterus, demonstrated that the virus was localized in glandular and epithelial cells. This study clearly demonstrates that goat uterine epithelial cells are susceptible to CAEV infection in vivo. This finding could help to further our understanding of the epidemiology of CAEV, and in particular the possibility of vertical transmission.

Published
2012
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5. Pdx-1 or Pdx-1-VP16 protein transduction induces β-cell gene expression in liver-stem WB cells

Author

Dubreil Laurence, Martignat Lionel, Delisle Juliette, Saï Pierre, Bach Jean-Marie, Louzier Vanessa, and Bösch Steffi

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Pancreatic duodenal homeobox-1 (Pdx-1) or Pdx-1-VP16 gene transfer has been shown to induce in vitro rat liver-stem WB cell conversion into pancreatic endocrine precursor cells. High glucose conditions were necessary for further differentiation into functional insulin-producing cells. Pdx-1 has the ability to permeate different cell types due to an inherent protein transduction domain (PTD). In this study, we evaluated liver-to-pancreas conversion of WB cells following Pdx-1 or Pdx-1-VP16 protein transduction. Findings WB cells were grown in high glucose medium containing Pdx-1 or Pdx-1-VP16 recombinant proteins for two weeks. β-like cell commitment was analysed by RT-PCR of pancreatic endocrine genes. We found that WB cells in high glucose culture spontaneously express pancreatic endocrine genes (Pdx-1, Ngn3, Nkx2.2, Kir6.2). Their further differentiation into β-like cells expressing genes related to endocrine pancreas development (Ngn3, NeuroD, Pax4, Nkx2.2, Nkx6.1, Pdx-1) and β-cell function (Glut-2, Kir6.2, insulin) was achieved only in the presence of Pdx-1(-VP16) protein. Conclusion These results demonstrate that Pdx-1(-VP16) protein transduction is instrumental for in vitro liver-to-pancreas conversion and is an alternative to gene therapy for β-cell engineering for diabetes cell therapy.

Published
2009
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6. Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate.

Author

Karpf, Sebastian, Glöckner Burmeister, Nina, Dubreil, Laurence, Ghosh, Shayantani, Hollandi, Reka, Pichon, Julien, Leroux, Isabelle, Henkel, Alessandra, Lutz, Valerie, Jurkevičius, Jonas, Latshaw, Alexandra, Kilin, Vasyl, Kutscher, Tonio, Wiggert, Moritz, Saavedra‐Villanueva, Oscar, Vogel, Alfred, Huber, Robert A., Horvath, Peter, Rouger, Karl, and Bonacina, Luigi

Published
2024
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7. Impact of swine influenza A virus on porcine reproductive and respiratory syndrome virus infection in alveolar macrophages.

Author

Grevelinger, Janaïna, Bourry, Olivier, Meurens, François, Perrin, Aline, Hervet, Caroline, Dubreil, Laurence, Simon, Gaëlle, and Bertho, Nicolas

Subjects
PORCINE reproductive & respiratory syndrome, SWINE influenza, ANIMAL herds, ALVEOLAR macrophages, VIRUS diseases
Abstract

Porcine respiratory disease complex represents a major challenge for the swine industry, with swine influenza A virus (swIAV) and porcine reproductive and respiratory syndrome virus (PRRSV) being major contributors. Epidemiological studies have confirmed the co-circulation of these viruses in pig herds, making swIAV-PRRSV co-infections expected. A couple of in vivo co-infection studies have reported replication interferences between these two viruses. Herein, using a reductionist in vitro model, we investigated the potential mechanisms of these in vivo interferences. We first examined the impact of swIAV on porcine alveolar macrophages (AMs) and its effects on AMs co-infection by PRRSV. This was done either in monoculture or in co-culture with respiratory tracheal epithelial cells to represent the complexity of the interactions between the viruses and their respective target cells (epithelial cells for swIAV and AMs for PRRSV). AMs were obtained either from conventional or specific pathogen-free (SPF) pigs. SwIAV replication was abortive in AMs, inducing cell death at high multiplicity of infections. In AMs from three out of four conventional animals, swIAV showed no impact on PRRSV replication. However, inhibition of PRRSV multiplication was observed in AMs from one animal, accompanied by an early increase in the expression of interferon (IFN)-I and IFN-stimulated genes. In AMs from six SPF pigs, swIAV inhibited PRRSV replication in all animals, with an early induction of antiviral genes. Co-culture experiments involving tracheal epithelial cells and AMs from either SPF or conventional pigs all showed swIAV-induced inhibition of PRRSV replication, together with early induction of antiviral genes. These findings highlight the complex interactions between swIAV and PRRSV in porcine AMs, and would suggest a role of host factors, such as sanitary status, in modulating viral propagation. Our co-culture experiments demonstrated that swIAV inhibits PRRSV replication more effectively in the presence of respiratory tracheal epithelial cells, suggesting a synergistic antiviral response between AMs and epithelial cells, consistent with in vivo experiments. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Confocal spectral microscopy, a non-destructive approach to follow contamination and biofilm formation of mCherry Staphylococcus aureus on solid surfaces

Author

Munir, Muhammad Tanveer, Maneewan, Nattar, Pichon, Julien, Gharbia, Mohammed, Oumarou-Mahamane, Ismael, Baude, Jessica, Thorin, Chantal, Lepelletier, Didier, Le Pape, Patrice, Eveillard, Matthieu, Irle, Mark, Pailhoriès, Hélène, Aviat, Florence, Belloncle, Christophe, Federighi, Michel, and Dubreil, Laurence

Published
2021
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10. Specific and label-free endogenous signature of dystrophic muscle by Synchrotron deep ultraviolet radiation

Author

Dubreil, Laurence, primary, Damane, Noreddine, additional, Fleurisson, Romain, additional, Charrier, Marine, additional, Pichon, Julien, additional, Leroux, Isabelle, additional, Schleder, Cindy, additional, Ledevin, Mireille, additional, Larcher, Thibaut, additional, Jamme, Frédéric, additional, Puentes, John, additional, and Rouger, Karl, additional

Published
2023
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15. The Internal Conduit System of the Swine Inverted Lymph Node

Author

Dubreil, Laurence, Ledevin, Mireille, Hervet, Caroline, Menard, Déborah, Philippe, Claire, Michel, François J., Larcher, Thibaut, Meurens, François, Bertho, Nicolas, Expertise en Anatomie Pathologique (APEX), Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Saskatchewan [Saskatoon] (U of S), and APEX, PAnTher, INRAE, Oniris is supported by Pays de la Loire, IBISA and NeurATRIS translational research infrastructure for innovative therapies in NeuroSciences. Biogenouest (the network of technology core facilities in Western France in life sciences and the environment, and by the Conseil Régional des Pays de la Loire). APEX platform is a Center of Excellence Nikon. Reagents and equipment were purchased thanks to the establishment grant obtained by FM from the Région Pays de la Loire (RFI Food for tomorrow-Cap aliment).

Subjects
Follicle, B-Lymphocytes, Swine, Macrophages, [SDV]Life Sciences [q-bio], Immunology, Lymph Node, Second harmonic generation, Fluorescence imaging, Mice, Endothelial cell, Animals, Immunology and Allergy, Lymph Nodes, Lymphocytes, Whole organ imaging, Lymphatic Vessels, B lymphocytes
Abstract

International audience; Lymph nodes (LN) are the crossroad where naïve lymphocytes, peripheral antigens and antigen presenting cells contact together in order to mount an adaptive immune response. For this purpose, LN are highly organized convergent hubs of blood and lymphatic vessels that, in the case of B lymphocytes, lead to the B cell follicles. Herein take place the selection and maturation of B cell clones producing high affinity antibodies directed against various antigens. Whereas the knowledge on the murine and human LN distribution systems have reached an exquisite precision those last years, the organization of the antigens and cells circulation into the inverted porcine LN remains poorly described. Using up to date microscopy tools, we described the complex interconnections between afferent lymphatics and blood vessels, perifollicular macrophages, follicular B cells and efferent blood vessels. We observed that afferent lymphatic sinuses presented an asymmetric Lyve-1 expression similar to the one observed in murine LN, whereas specialized perifollicular sinuses connect the main afferent lymphatic sinus to the B cell follicles. Finally, whereas it was long though that mature B cells egress from the inverted LN in the T cell zone through HEV, our observations are in agreement with mature B cells accessing the efferent blood circulation in the efferent, subcapsular area. This understanding of the inverted porcine LN circuitry will allow a more accurate exploration of swine pathogens interactions with the immune cells inside the LN structures. Moreover, the mix between similarities and differences of porcine inverted LN circuitry with mouse and human normal LN shall enable to better apprehend the functions and malfunctions of normal LN from a new perspective.

Published
2022
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18. To Help You Make 'Transparisation' an Effective Tool

Author

Dubreil, Laurence, Belcram, Katia, Chaumeton, Cholé, d'Angelo, Romina, Godefroy, David, Michel, François, Simion, Matthieu, Teillon, Jeremie, and BABARIT, Candice

Subjects
[SDV] Life Sciences [q-bio]
Published
2022

19. L’axe Bio‐Imagerie du réseau interrégional Biogenouest

Author

Dubreil, Laurence, Eliat, Pierre-Antoine, BABARIT, Candice, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Plate-forme Rennaise d'Imagerie et Spectroscopie Structurale et Métabolique (PRISM), and Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
2022

22. Systemic Delivery of Allogenic Muscle Stem Cells Induces Long-Term Muscle Repair and Clinical Efficacy in Duchenne Muscular Dystrophy Dogs

Author

Rouger, Karl, Larcher, Thibaut, Dubreil, Laurence, Deschamps, Jack-Yves, Le Guiner, Caroline, Jouvion, Gregory, Delorme, Bruno, Lieubeau, Blandine, Carlus, Marine, Fornasari, Benoît, Theret, Marine, Orlando, Priscilla, Ledevin, Mireille, Zuber, Céline, Leroux, Isabelle, Deleau, Stéphane, Guigand, Lydie, Testault, Isabelle, Le Rumeur, Elisabeth, Fiszman, Marc, and Chérel, Yan

Published
2011
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24. La transparisation sur la plateforme APEX

Author

Dubreil, Laurence, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), and Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2021

25. 3D characterization of cardiac fibrosis in dystrophic rat: collagen SHG imaging on CUBIC cleared heart

Author

Pichon, Julien, Ledevin, Mireille, Larcher, Thibaut, Jamme, Frédéric, Rouger, Karl, Dubreil, Laurence, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Synchrotron SOLEIL (SSOLEIL), and Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

26. Hygienic Perspectives of Wood in Healthcare Buildings

Author

Munir, Muhammad Tanveer, Pape, Patrice Le, Munir, Muhammad, Pailhoriès, Hélène, Aviat, Florence, Lepelletier, Didier, Pape, Patrice, Dubreil, Laurence, Irle, Mark, Buchner, Julia, EVEILLARD, Matthieu, Federighi, Michel, Belloncle, Christophe, Ecole supérieure du bois (ESB), Ecole supérieure du bois, Centre hospitalier universitaire de Nantes (CHU Nantes), Institut de Biologie en Santé (PHB-IRIS) [CHU Angers] (IBS), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Expertise en Anatomie Pathologique (APEX), Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sécurité des Aliments (SECALIM), and Ecole Nationale Vétérinaire de Nantes-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
0106 biological sciences, 0301 basic medicine, Eveillard, Munir, Dubreil, 030106 microbiology, green buildings, Aviat, Federighi, 01 natural sciences, complex mixtures, M, 03 medical and health sciences, M.T, Physical structure, Environmental protection, 010608 biotechnology, Water content, Lepelletier, Buchner, et al surface hygiene, Pailhoriès, technology, industry, and agriculture, J, H, Cleanability, L, Smooth surface, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, F, D, Environmental science, antimicrobial, Pape, biofilms, surface hygiene, P.L, wood, Irle
Abstract

International audience; Wood materials are being adopted as nature-based architectural themes inside the healthcare buildings. Concern is raised that the organic and porous character of wood might support microbial survival. Therefore, this review discusses the hygienic properties of wood including the antimicrobial potential and its cleanability in comparison to smooth surface materials. In general, wood has antimicrobial properties owing to its chemical composition and physical structure. However, the hygienic potential of wood is influenced by the type of wood, age of wood, the cleaning method, surface treatment, and its moisture content. This information is intended to guide decision-makers regarding the use of wood in hygienically sensitive places and researchers to help them identify the variables for better utilizing the hygienic potential of this material.

Published
2021
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27. Molecular and functional signatures of distinct subpopulations of extracellular vesicles provide a rationale for beta-cell mediated immune disease

Author

MIGNOT, Grégoire, Giri, Khem Raj, De Beaurepaire, Laurence, Jegou, Dominique, Lavy, Margot, Mosser, Mathilde, Dupont, Aurelien, Fleurisson, Romain, Dubreil, Laurence, Pichon, Julien, van Endert, Peter Van, Bach, Jean-Marie, Bosch, Steffi, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Microscopie de Rennes (MRic), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Descartes - Paris 5 (UPD5), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

28. Investigating bio-distribution of mCherry S. aureus on wood material using CSLM

Author

Dubreil, Laurence, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), and Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

29. Multiphotonic microscopy and tissue clearing for cell tracking in thick sample

Author

Dubreil, Laurence, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), and Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2021

30. Harmonic nanoparticles: an enabling labelling tool for stem cell-tracking by SWIR multiphoton microscopy

Author

Dubreil, Laurence, karpf, sebastian, Campargue, Gabriel, La Volpe, Luca, Gerber-Lemaire, Sandrine, Mugnier, Yannick, Rouger, Karl, Bonacina, Luigi, BABARIT, Candice, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), institute of biomedical optics, Université de Genève (UNIGE), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratoire SYstèmes et Matériaux pour la MEcatronique (SYMME), and Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

31. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages

Author

Labadie, Karine, Larcher, Thibaut, Joubert, Christophe, Mannioui, Abdelkrim, Delache, Benoit, Brochard, Patricia, Guigand, Lydie, Dubreil, Laurence, Lebon, Pierre, Verrier, Bernard, Lamballerie, Xavier de, Suhrbier, Andreas, Cherel, Yan, Grand, Roger Le, and Roques, Pierre

Subjects
Chikungunya fever -- Causes of -- Distribution -- Drug therapy -- Research, Macrophages -- Health aspects -- Research, Company distribution practices, Health care industry
Abstract

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Islands and India has stressed the need to better understand the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic and/or prophylactic strategies., Introduction Chikungunya virus (CHIKV) is a mosquito-borne alphavirus (family Togaviridae) first described in Africa in 1953 (1). CHIKV belongs to a group of widely distributed arthrogenic alphaviruses, which include the [...]

Published
2010
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32. Hygienic Perspectives of Wood in Healthcare Buildings

Author

Munir, Muhammad Tanveer, primary, Pailhoriès, Hélène, additional, Aviat, Florence, additional, Lepelletier, Didier, additional, Pape, Patrice Le, additional, Dubreil, Laurence, additional, Irle, Mark, additional, Buchner, Julia, additional, Eveillard, Matthieu, additional, Federighi, Michel, additional, and Belloncle, Christophe, additional

Published
2021
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34. Label free imaging with harmonic generation microscopy and endogeneous fluorescence investigations for food, ecotoxicology and health issues

Author

Dubreil, Laurence, Chevalier, Sylvie, Cachot, Jérôme, Colle, Marie-Anne, Rouger, Karl, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Laboratoire de génie des procédés - environnement - agroalimentaire (GEPEA), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-Institut Universitaire de Technologie - Nantes (IUT Nantes), Université de Nantes (UN)-Institut Universitaire de Technologie Saint-Nazaire (IUT Saint-Nazaire), Université de Nantes (UN)-Institut Universitaire de Technologie - La Roche-sur-Yon (IUT La Roche-sur-Yon), Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Université Bretagne Loire (UBL), Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), and BABARIT, Candice

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

35. High-speed two-photon microscopy with spectro-temporal laser imaging by diffractive excitation (SLIDE)

Author

karpf, sebastian, Dubreil, Laurence, Rouger, Karl, Huber, Robert, institute of biomedical optics, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), and Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

36. Spectral confocal microscopy : an innovative approach to investigate bacterial contamination on wood surface

Author

Dubreil, Laurence, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Développement et Pathologie du Tissu Musculaire (DPTM), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Spectral confocal microscopy : an innovative approach to investigate bacterial contamination on wood surface. Journée animation scientifique Bois H2

Published
2020

37. Human MuStem cell grafting into infarcted rat heart attenuates adverse tissue remodeling and preserves cardiac function hMuStem cells preserve function of infarcted heart

Author

RANNOU, Alice, Toumaniantz, Gilles, Larcher, Thibaut, Leroux, Isabelle, Ledevin, Mireille, Hivonnait, Agnès, Babarit, Candice, Fleurisson, Romain, Dubreil, Laurence, Ménoret, Séverine, Anegon, Ignacio, Charpentier, Flavien, Rouger, Karl, Guével, Laétitia, CCSD, Accord Elsevier, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Nantes (UN), UMR1064,ITUN, Transgénèse Rat et ImmunoPhénomique, IBiSA / Biogenouest, Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX)

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV]Life Sciences [q-bio], [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Myocardial infarction is one of the leading causes of mortality and morbidity worldwide. Whereas transplantation of several cell types into the infarcted heart has produced promising preclinical results, clinical studies using analogous human cells have shown limited structural and functional benefits. In dogs and humans, we have described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits. With the consideration of these features that are restricted or absent in cells tested so far for myocardial infarction, we wanted to investigate the capacity of human MuStem cells to repair infarcted hearts. Their local administration in immunodeficient rats 1 week after induced infarction resulted in reduced fibrosis and increased angiogenesis 3 weeks post-transplantation. Importantly, foci of human fibers were detected in the infarct site. Treated rats also showed attenuated left-ventricle dilation and preservation of contractile function. Interestingly, no spontaneous arrhythmias were observed. Our findings support the potential of MuStem cells, which have already been proposed as therapeutic candidates for dystrophic patients, to treat myocardial infarction and position them as an attractive tool for muscle-regenerative medicine.

Published
2020
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40. Survival of Bacterial Strains on Wood (Quercus petraea) Compared to Polycarbonate, Aluminum and Stainless Steel

Author

Chen, Ju-Chi, primary, Munir, Muhammad Tanveer, additional, Aviat, Florence, additional, Lepelletier, Didier, additional, Le Pape, Patrice, additional, Dubreil, Laurence, additional, Irle, Mark, additional, Federighi, Michel, additional, Belloncle, Christophe, additional, Eveillard, Matthieu, additional, and Pailhoriès, Hélène, additional

Published
2020
Full Text
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42. Molecular and Functional Diversity of Distinct Subpopulations of the Stressed Insulin-Secreting Cell's Vesiculome

Author

Giri, Khem Raj, primary, de Beaurepaire, Laurence, additional, Jegou, Dominique, additional, Lavy, Margot, additional, Mosser, Mathilde, additional, Dupont, Aurelien, additional, Fleurisson, Romain, additional, Dubreil, Laurence, additional, Collot, Mayeul, additional, Van Endert, Peter, additional, Bach, Jean-Marie, additional, Mignot, Gregoire, additional, and Bosch, Steffi, additional

Published
2020
Full Text
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43. Porcine Reproductive and Respiratory Syndrome Virus Interferes with Swine Influenza A Virus Infection of Epithelial Cells

Author

Saade, Georges, primary, Ménard, Déborah, additional, Hervet, Caroline, additional, Renson, Patricia, additional, Hue, Erika, additional, Zhu, Jianzhong, additional, Dubreil, Laurence, additional, Paillot, Romain, additional, Pronost, Stéphane, additional, Bourry, Olivier, additional, Simon, Gaëlle, additional, Dupont, Joëlle, additional, Bertho, Nicolas, additional, and Meurens, François, additional

Published
2020
Full Text
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44. Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?

Author

Bey, Karim, primary, Deniaud, Johan, additional, Dubreil, Laurence, additional, Joussemet, Béatrice, additional, Cristini, Joseph, additional, Ciron, Carine, additional, Hordeaux, Juliette, additional, Le Boulc’h, Morwenn, additional, Marche, Kevin, additional, Maquigneau, Maud, additional, Guilbaud, Michaël, additional, Moreau, Rosalie, additional, Larcher, Thibaut, additional, Deschamps, Jack-Yves, additional, Fusellier, Marion, additional, Blouin, Véronique, additional, Sevin, Caroline, additional, Cartier, Nathalie, additional, Adjali, Oumeya, additional, Aubourg, Patrick, additional, Moullier, Philippe, additional, and Colle, Marie-Anne, additional

Published
2020
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46. Molecular and functional diversity of distinct subpopulations of extracellular vesicles from stressed pancreatic beta cells: implications for autoimmunity

Author

Giri, Khem Raj, primary, de Beaurepaire, Laurence, additional, Jegou, Dominique, additional, Lavy, Margot, additional, Mosser, Mathilde, additional, Dupont, Aurelien, additional, Fleurisson, Romain, additional, Dubreil, Laurence, additional, Collot, Mayeul, additional, Van Endert, Peter, additional, Bach, Jean-Marie, additional, Mignot, Gregoire, additional, and Bosch, Steffi, additional

Published
2020
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47. Chemical modification of the adeno-associated virus capsid to improve gene delivery

Author

Mével, Mathieu, primary, Bouzelha, Mohammed, additional, Leray, Aurélien, additional, Pacouret, Simon, additional, Guilbaud, Mickael, additional, Penaud-Budloo, Magalie, additional, Alvarez-Dorta, Dimitri, additional, Dubreil, Laurence, additional, Gouin, Sébastien G., additional, Combal, Jean Philippe, additional, Hommel, Mirja, additional, Gonzalez-Aseguinolaza, Gloria, additional, Blouin, Véronique, additional, Moullier, Philippe, additional, Adjali, Oumeya, additional, Deniaud, David, additional, and Ayuso, Eduard, additional

Published
2020
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50. La surexpression de FoxO3a prévient la surcharge en glycogène et la dérégulation du flux autophagique dans le muscle squelettique dans la maladie de Pompe

Author

PICHON, JULIEN, Lagalice, Lydie, Deniaud, Johan, MAURIER, Virginie, Babarit, Candice, Larcher, Thibaut, Fleurisson, Romain, Dubreil, Laurence, Ayuso, Eduard, Ciron, Carine, Rouger, Karl, Colle, Marie-Anne, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques (Inserm UMR 1089), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2019

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