1. Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems
- Author
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Raphael Rytz, Liliane Abuin, Richard Benton, Ana F. Silbering, Yael Grosjean, Gregory S.X.E. Jefferis, Pavan Ramdya, Center for Integrative Genomics - Institute of Bioinformatics, Génopode (CIG), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Medical Research Council Laboratory of Molecular Biology, Centre intégratif de génomique, Université de Lausanne (UNIL), Université de Lausanne ( UNIL ), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), and Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)
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MESH: Olfactory Perception ,histology growth ,MESH: Drosophila ,receptor ,Chemosensory Receptors ,MESH : Animals, Genetically Modified ,Ligands ,Receptors, Odorant ,Protein-Coupled Receptors ,ligand ,Animals, Genetically Modified ,MESH : Maze Learning ,0302 clinical medicine ,MESH : Biological Evolution ,Odorant Receptors ,MESH: Ligands ,Drosophila Proteins ,MESH: Receptors, Odorant ,animal ,MESH: Animals ,Receptor ,Antennal Lobe ,0303 health sciences ,MESH : Ligands ,MESH: Receptors, Ionotropic Glutamate ,biology ,General Neuroscience ,MESH : Receptors, Ionotropic Glutamate ,Articles ,Olfactory Pathways ,MESH : Odors ,Olfactory transduction ,development physiology ,medicine.anatomical_structure ,Local Interneurons ,Drosophila ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,MESH : Mutation ,In-Vivo ,Evolutionary Robotics ,maze learning physiology ,Ionotropic effect ,anatomy ,MESH: Mutation ,odor ,MESH: Drosophila Proteins ,Sensory system ,glutamate ,MESH: Biological Evolution ,biological evolution ,drosophila genetic ,physiology ,mutation ,olfactory pathway ,ionotropic ,odorant ,Receptors, Ionotropic Glutamate ,Olfactory Receptor Neurons ,MESH: Animals, Genetically Modified ,03 medical and health sciences ,MESH : Olfactory Perception ,MESH : Receptors, Odorant ,medicine ,Animals ,Biological Evolution ,Drosophila/genetics ,Drosophila Proteins/agonists ,Drosophila Proteins/genetics ,Maze Learning/physiology ,Mutation ,Odors ,Olfactory Pathways/anatomy & histology ,Olfactory Pathways/growth & development ,Olfactory Perception/genetics ,Olfactory Perception/physiology ,Olfactory Receptor Neurons/anatomy & histology ,Olfactory Receptor Neurons/growth & development ,Receptors, Ionotropic Glutamate/agonists ,Receptors, Ionotropic Glutamate/genetics ,Receptors, Odorant/genetics ,Receptors, Odorant/physiology ,MESH : Drosophila ,Maze Learning ,Ionotropic Glutamate Receptors ,030304 developmental biology ,Mosquito Anopheles-Gambiae ,Communication ,Malaria Mosquito ,MESH: Odors ,MESH : Olfactory Pathways ,business.industry ,MESH: Maze Learning ,MESH: Olfactory Receptor Neurons ,biology.organism_classification ,Olfactory Perception ,MESH : Drosophila Proteins ,[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Odorants ,MESH : Olfactory Receptor Neurons ,Antennal lobe ,Neuron ,MESH : Animals ,business ,Neuroscience ,030217 neurology & neurosurgery ,Function (biology) ,MESH: Olfactory Pathways ,Male Courtship Behavior - Abstract
author can archive publisher's version/PDF (embargo 6 months) ; 1529-2401 (Electronic ISSN); International audience; To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.
- Published
- 2011
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