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Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems
- Source :
- Journal of Neuroscience, Journal of Neuroscience, Society for Neuroscience, 2011, 31 (38), pp.13357-13375. ⟨10.1523/jneurosci.2360-11.2011⟩, Journal of Neuroscience, Society for Neuroscience, 2011, 31 (38), pp.13357-13375. ⟨10.1523/JNEUROSCI.2360-11.2011⟩, Journal of Neuroscience, Society for Neuroscience, 2011, 31 (38), pp.13357-13375. 〈10.1523/JNEUROSCI.2360-11.2011〉, Journal of Neuroscience 38 (31), 13357-13375. (2011), Journal of Neuroscience, vol. 31, no. 38, pp. 13357-13375
- Publication Year :
- 2011
-
Abstract
- author can archive publisher's version/PDF (embargo 6 months) ; 1529-2401 (Electronic ISSN); International audience; To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.
- Subjects :
- MESH: Olfactory Perception
histology growth
MESH: Drosophila
receptor
Chemosensory Receptors
MESH : Animals, Genetically Modified
Ligands
Receptors, Odorant
Protein-Coupled Receptors
ligand
Animals, Genetically Modified
MESH : Maze Learning
0302 clinical medicine
MESH : Biological Evolution
Odorant Receptors
MESH: Ligands
Drosophila Proteins
MESH: Receptors, Odorant
animal
MESH: Animals
Receptor
Antennal Lobe
0303 health sciences
MESH : Ligands
MESH: Receptors, Ionotropic Glutamate
biology
General Neuroscience
MESH : Receptors, Ionotropic Glutamate
Articles
Olfactory Pathways
MESH : Odors
Olfactory transduction
development physiology
medicine.anatomical_structure
Local Interneurons
Drosophila
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
MESH : Mutation
In-Vivo
Evolutionary Robotics
maze learning physiology
Ionotropic effect
anatomy
MESH: Mutation
odor
MESH: Drosophila Proteins
Sensory system
glutamate
MESH: Biological Evolution
biological evolution
drosophila genetic
physiology
mutation
olfactory pathway
ionotropic
odorant
Receptors, Ionotropic Glutamate
Olfactory Receptor Neurons
MESH: Animals, Genetically Modified
03 medical and health sciences
MESH : Olfactory Perception
MESH : Receptors, Odorant
medicine
Animals
Biological Evolution
Drosophila/genetics
Drosophila Proteins/agonists
Drosophila Proteins/genetics
Maze Learning/physiology
Mutation
Odors
Olfactory Pathways/anatomy & histology
Olfactory Pathways/growth & development
Olfactory Perception/genetics
Olfactory Perception/physiology
Olfactory Receptor Neurons/anatomy & histology
Olfactory Receptor Neurons/growth & development
Receptors, Ionotropic Glutamate/agonists
Receptors, Ionotropic Glutamate/genetics
Receptors, Odorant/genetics
Receptors, Odorant/physiology
MESH : Drosophila
Maze Learning
Ionotropic Glutamate Receptors
030304 developmental biology
Mosquito Anopheles-Gambiae
Communication
Malaria Mosquito
MESH: Odors
MESH : Olfactory Pathways
business.industry
MESH: Maze Learning
MESH: Olfactory Receptor Neurons
biology.organism_classification
Olfactory Perception
MESH : Drosophila Proteins
[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Odorants
MESH : Olfactory Receptor Neurons
Antennal lobe
Neuron
MESH : Animals
business
Neuroscience
030217 neurology & neurosurgery
Function (biology)
MESH: Olfactory Pathways
Male Courtship Behavior
Subjects
Details
- Language :
- English
- ISSN :
- 02706474 and 15292401
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....d46ff98b04e012810d7f2bceacfc3927
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.2360-11.2011