1. Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization
- Author
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Dahlia N. Amato, Olga V. Mavrodi, Dmitri V. Mavrodi, William B. Martin, Derek L. Patton, Keith H. Parsons, Douglas V. Amato, and Sarah N. Swilley
- Subjects
chemistry.chemical_classification ,Antifungal ,Materials science ,Polymers and Plastics ,medicine.drug_class ,Organic Chemistry ,Acetal ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Antimicrobial ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Photopolymer ,chemistry ,Materials Chemistry ,Thiol ,medicine ,Organic chemistry ,0210 nano-technology ,Cytotoxicity ,Ene reaction ,High humidity - Abstract
We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAs derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAs enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.
- Published
- 2022