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A bio-based pro-antimicrobial polymer network via degradable acetal linkages
- Source :
- Acta Biomaterialia. 67:196-205
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- The synthesis of a fully degradable, bio-based, sustained release, pro-antimicrobial polymer network comprised of degradable acetals (PANDA) is reported. The active antimicrobial agent - p-anisaldehyde (pA) (an extract from star anise) - was converted into a UV curable acetal containing pro-antimicrobial monomer and subsequently photopolymerized into a homogenous thiol-ene network. Under neutral to acidic conditions (pH 8), the PANDAs undergo surface erosion and exhibit sustained release of pA over 38 days. The release of pA from PANDAs was shown to be effective against both bacterial and fungal pathogens. From a combination of confocal microscopy and transmission electron microscopy, we observed that the released pA disrupts the cell membrane. Additionally, we demonstrated that PANDAs have minimal cytotoxicity towards both epithelial cells and macrophages. Although a model platform, these results point to promising pathways for the design of fully degradable sustained-release antimicrobial systems with potential applications in agriculture, pharmaceuticals, cosmetics, household/personal care, and food industries.With the increasing number of patients prescribed immunosuppressants coupled with the rise in antibiotic resistance - life-threatening microbial infections are a looming global threat. With limited success within the antibiotic pipeline, nature-based essential oils (EOs) are being investigated for their multimodal effectiveness against microbes. Despite the promising potential of EOs, difficulties in their encapsulation, limited water solubility, and high volatility limit their use. Various studies have shown that covalent attachment of these EO derivatives to polymers can mitigate these limitations. The current study presents the synthesis of a fully-degradable, sustained release, cytocompatible, pro-antimicrobial acetal network derived from p-anisaldehyde. This polymer network design provides a pathway toward application-specific EO releasing materials with quantitative encapsulation efficiencies, sustained release, and broad-spectrum antimicrobial activity.
- Subjects :
- Antifungal Agents
Polymers
Biomedical Engineering
Bio based
Biocompatible Materials
Microbial Sensitivity Tests
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry
Article
Biomaterials
Mice
chemistry.chemical_compound
Acetals
Anti-Infective Agents
Antimicrobial polymer
Chlorocebus aethiops
Animals
Vero Cells
Molecular Biology
chemistry.chemical_classification
Aqueous solution
Bacteria
Cell Death
Cell Membrane
Acetal
Fungi
General Medicine
Polymer
021001 nanoscience & nanotechnology
Antimicrobial
Combinatorial chemistry
0104 chemical sciences
Kinetics
RAW 264.7 Cells
Monomer
chemistry
Covalent bond
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 17427061
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Acta Biomaterialia
- Accession number :
- edsair.doi.dedup.....5191969d53a0f8dfc6fbc33669b13173