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7 results on '"Dorkin, J. R."'

3. Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivoElectronic supplementary information (ESI) available: Experimental details and 1H NMR structure determination. See DOI: 10.1039/c6bm00683c

Author

LuoThese authors contributed equally to this work., X., Wang, W., Dorkin, J. R., Veiseh, O., Chang, P. H., Abutbul-Ionita, I., Danino, D., Langer, R., Anderson, D. G., and Dong, Y.

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Published
2016
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4. Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.

Author

Luo X, Wang W, Dorkin JR, Veiseh O, Chang PH, Abutbul-Ionita I, Danino D, Langer R, Anderson DG, and Dong Y

Subjects
Animals, Mice, Nanostructures administration & dosage, RNA, Small Interfering chemistry, Amines chemistry, Nanostructures chemistry, Polymers chemistry, RNA, Small Interfering administration & dosage
Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Published
2016
Full Text
View/download PDF

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