Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivoElectronic supplementary information (ESI) available: Experimental details and 1H NMR structure determination. See DOI: 10.1039/c6bm00683c

Authors :: LuoThese authors contributed equally to this work., X.
Wang, W.
Dorkin, J. R.
Veiseh, O.
Chang, P. H.
Abutbul-Ionita, I.
Danino, D.
Langer, R.
Anderson, D. G.
Dong, Y.
Source :: Biomaterials Science; 2016, Vol. 5 Issue: 1 p38-40, 3p
Publication Year :: 2016
Abstract: Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

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