1. A biomimetic lubricating nanosystem for synergistic therapy of osteoarthritis.
- Author
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Gong P, Wang M, Wang J, Li J, Wang B, Bai X, Liu J, Liu Z, Wang D, and Liu W
- Subjects
- Humans, Animals, Metal-Organic Frameworks chemistry, Metal-Organic Frameworks pharmacology, Surface Properties, Lubrication, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents pharmacology, Particle Size, Dopamine chemistry, Dopamine pharmacology, Drug Liberation, Osteoarthritis drug therapy, Osteoarthritis pathology, Osteoarthritis metabolism, Biomimetic Materials chemistry, Biomimetic Materials pharmacology, Hyaluronic Acid chemistry, Hyaluronic Acid pharmacology
- Abstract
Failure of articular cartilage lubrication and inflammation are the main causes of osteoarthritis (OA), and integrated treatment realizing joint lubrication and anti-inflammation is becoming the most effective treat model. Inspired by low friction of human synovial fluid and adhesive chemical effect of mussels, our work reports a biomimetic lubricating system that realizes long-time lubrication, photothermal responsiveness and anti-inflammation property. To build the system, a dopamine-mediated strategy is developed to controllably graft hyaluronic acid on the surface of metal organic framework. The design constructs a biomimetic core-shell structure that has good dispersity and stability in water with a high drug loading ratio of 99%. Temperature of the solution rapidly increases to 55 °C under near-infrared light, and the hard-soft lubricating system well adheres to wear surfaces, and greatly reduces frictional coefficient by 75% for more than 7200 times without failure. Cell experiments show that the nanosystem enters cells by endocytosis, and releases medication in a sustained manner. The anti-inflammatory outcomes validate that the nanosystem prevents the progression of OA by down-regulating catabolic proteases and pain-related genes and up-regulating genes that are anabolic in cartilage. The study provides a bioinspired strategy to employ metal organic framework with controlled surface and structure for friction reduction and anti-inflammation, and develops a new concept of OA synergistic therapy model for practical applications., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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