Search

The phytochemical investigation of extracts from the radix of Angelica sinensis yielded a new phthalide dimer, 3,3'Z-6.7',7.6'-diligustilide, along with a known dimer, levistolide A. Their structures were established on the basis of spectral data, particularly using 1D-NMR and several 2D shift-correlated NMR pulse sequences (¹H-¹H COSY, HSQC, HMBC and NOESY).

A highly efficient oxidative dimerization of thioamides by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) is reported. The reaction is carried out in ClCH2CH2Cl at room temperature. The corresponding 3,5-disubstituted 1,2,4-thiadiazoles are obtained in good to excellent yields.

The phytochemical investigation of extracts from the root barks of Lycium chinense yielded a new furolactone-type lignan, lyciumin (1). Its structure and absolute configurations were established on the basis of spectral data, particularly by the use of 1D NMR, 2D shift-correlated NMR pulse sequences ((1)H-(1)H COSY, HSQC, HMBC and ROESY) and CD spectra.

The combined reagent of iodobenzene diacetate (or polymer-supported iodobenzene diacetate) with iodine was used as an effective iodinating agent of pyrazoles to the corresponding 4-iodopyrazole derivatives at room temperature with high yields.

Iodobenzene diacetate was used as an effective oxidizing agent for the oxidation of 1,4-dihydropyridines to the corresponding pyridine derivatives at room temperature with high yields.

A facile synthesis of 3,5-disubstituted 1,2,4-thiadiazoles by oxidative dimerization of thioamides using polymer-supported iodobenzene diacetate has been reported.

Polymer-supported phenyliodine bis(trifluoroacetate) was prepared and used in the regeneration of carbonyl function from carbonyl derivatives.

In the title compound, [CuCl2(C9H12N2O)], the Cu(II) atom is coordinated by two Cl- anions and two N atoms of one O-ethyl 3-methylpyridine-2-carboximidic acid molecule in a slightly distorted square-planar geometry, with Cu-N distances of 2.0483 (17) and 1.9404 (18) A, and Cu-Cl distances of 2.2805 (10) and 2.2275 (14) A. In addition, each Cu(II) atom is connected by one Cl- anion and the Cu(II) atom from a neighbouring molecule, with Cu...Cl and Cu...Cu distances of 2.9098 (13) and 3.4022 (12) A, respectively, and, therefore, a centrosymmetric dimer is formed. Adjacent molecular dimers are connected by pi-pi stacking interactions between pyridine rings to form a zigzag molecular chain. The molecular chains are also enforced by N-H...Cl and C-H...Cl interactions.

A new norlignan glycoside, named iso-agatharesinoside (2), and its aglycone, iso-agatharesinol (1), were isolated from the tuberous roots of Asparagus cochinchinensis. Their structures were established on the basis of spectral data, particularly by the use of 1D NMR and several 2D shift-correlated NMR pulse sequences (1H-1H COSY, HSQC, HMBC and ROESY).

A highly efficient oxidative dimerization of thioamides by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) is reported. The reaction is carried out in ClCH2CH2Cl at room temperature. The corresponding 3,5-disubstituted 1,2,4-thiadiazoles are obtained in good to excellent yields.

The combined reagent of iodobenzene diacetate (or polymer-supported iodobenzene diacetate) with iodine or bromine was used as an effective halogenative agent of 6-methyluracil derivatives to the corresponding 5-halo-6-methyluracil derivatives at room temperature with high yields.