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211 results on '"Domenici, R"'

1. Whiplash-Associated Disorders: Clinical and medico-legal guidelines on the methods of ascertainment

Author

Ferrara, S. D., Ananian, V., Baccino, E., Banczerowski, P., Bordignon, D., Boscolo-Berto, R., Domenici, R., Gorriz Quevedo, J., Graw, M., Hell, W., Hernandez Cueto, C., Knudsen, P. J. T., Masiero, S., Montisci, M., Norelli, G. A., Pinchi, V., Raudys, R., Raul, J. S., Sterzik, V., Tessitore, E., Tuusov, J., Vanezis, P., Vermylen, Y., Vieira, D. N., Viel, G., Viero, A., Villanueva, E., and Zoia, R.

Published
2016
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2. Valutazione medico-legale del danno biologico nella persona anziana. I risultati della consensus conference multidisciplinare

Author

Castellani, G. L., Molinelli, A., Feola, A., PAOLA FORTI, Lunardelli, M. L., Vignatelli, L., Albertini, S., Bolcato, M., Camerlingo, M., Corbi, G., Leo, D., Nicolò, A., Stefano, F., Erba, A., Di Giulio, P., Domenici, R., Fedeli, P., Ferrara, N., Frigiolini, F., Gianniti, P., Gili, E., Iannone, P., Lovato, A., Marengoni, A., Marozzi, F., Martelloni, M., Mecocci, P., Polo, L., Portas, M., Rossi, P., Scorretti, C., Trabucchi, M., Volpato, S., Zoja, R., Ingravallo, F., Castellani G.L., Molinelli A., Feola A., Forti P., Lunardelli M.L., Vignatelli L., Albertini S., Bolcato M., Camerlingo M., Corbi G., De Leo D., De Nicolo A., De Stefano F., Dell'Erba A., Di Giulio P., Domenici R., Fedeli P., Ferrara N., Frigiolini F., Gianniti P., Gili E., Iannone P., Lovato A., Marengoni A., Marozzi F., Martelloni M., Mecocci P., Polo L., Portas M., Rossi P., Scorretti C., Trabucchi M., Volpato S., Zoja R., Ingravallo F., Castellani, G. L., Molinelli, A., Feola, A., Forti, P., Lunardelli, M. L., Vignatelli, L., Albertini, S., Bolcato, M., Camerlingo, M., Corbi, G., De Leo, D., De Nicolo, A., De Stefano, F., Dell'Erba, A., Di Giulio, P., Domenici, R., Fedeli, P., Ferrara, N., Frigiolini, F., Gianniti, P., Gili, E., Iannone, P., Lovato, A., Marengoni, A., Marozzi, F., Martelloni, M., Mecocci, P., Polo, L., Portas, M., Rossi, P., Scorretti, C., Trabucchi, M., Volpato, S., Zoja, R., and Ingravallo, F.

Subjects
Valutazione medico legale. Danno biologico. Anziano. Stato anteriore. Valutazione multidimensionale. Consensus conference
Abstract

Personal damage evaluation in older people is complex, and the scarcity of evidence is hindering the development of formal guidelines on the subject. The main objectives of the first multidisciplinary Consensus Conference on Medico-Legal Assessment of Personal Damage in Older People were to increase knowledge on the subject and establish standard procedures in this field. The conference, organized according to the guidelines issued by the Italian National Institute of Health (ISS), was held in Bologna (Italy) on June 8, 2019 with the support of national scientific societies, professional organizations, and stakeholders. The Scientific Technical Committee prepared 16 questions on 4 thematic areas: (1) differences in injury outcomes in older people compared to younger people and their relevance in personal damage assessment; (2) pre-existing status reconstruction and evaluation; (3) medico-legal examination procedures; (4) multidimensional assessment and scales. The Scientific Secretariat reviewed relevant literature and documents, rated their quality, and summarized evidence. The present report describes Conference methods and results, including a summary of evidence supporting each statement, and areas requiring further investigation. The methodological recommendations issued during the Conference may be useful in several contexts of damage assessment, or to other medico-legal evaluation fields.

Published
2020

15. Y-chromosome haplotypes in Italy: the GEFI collarborative database.

Author

Presciuttini, S., Caglia, A., Alu, M., Asmundo, A., Buscemi, L., Caenazzo, L., Carnevali, E., Carra, E., De Battisti, Z., De Stefano, F., Domenici, R., Piccinini, A., Resta, N., Ricci, Ugo, and Pascali, V.L.

Subjects
Population genetics -- Research, Forensic genetics -- Research, Forensic anthropology -- Research, Italians -- Physiological aspects
Published
2001

16. Allele Frequencies of the HUMFES/FPS System in Northern and Central Italy

Author

Tagliabracci, A., primary, Paoli, M., additional, Rodriguez, D., additional, Cucurachi, N., additional, Buscemi, L., additional, Ferrara, S. D., additional, Previderè, C., additional, Peloso, G., additional, Riva, A., additional, Pierucci, G., additional, Domenici, R., additional, Fornaciari, S., additional, Spinetti, I., additional, Nardone, M., additional, and Bargagna, M., additional

Published
1996
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20. X-chromosome in Italy: A database of 29 STR markers

Author

Presciuttini, S., Toni, C., Alù, M., Asmundo, A., Baldassarri, L., Barbaro, A., Caenazzo, L., Carnevali, E., Cerri, N., D’Aloia, E., Di Nunzio, C., Onofri, V., Peloso, G., Pelotti, S., Piccinini, A., Robino, C., Turrina, S., Venturi, M., and Domenici, R.

Published
2011
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27. Potential serotype coverage of three pneumococcal conjugate vaccines against invasive pneumococcal infection in Italian children

Author

Azzari, Chiara, Moriondo, Maria, Cortimiglia, Martina, Valleriani, C, Canessa, C, Indolfi, G, Ricci, S, De Martino, Maurizio, Resti, M, Collaborators: Agostiniani R, Italian group for the study of Invasive Pneumococcal D. i. s. e. a. s. e., Allievi, P, Allù, G, Amigoni, A, Bernardi, P, Bernardini, R, Biban, P, Bigi, M, Boldrini, A, Bossi, G, Bottone, U, Cardinale, A, Cardona, A, Castronari, R, Celandroni, A, Chiossi, M, Colleselli, P, Correra, A, D'Ascola, G, D'Aquino, A, De Benedictis FM, Dini, E, Dollfus, L, Domenici, R, Flacco, V, Furbetta, M, Gaetti, Mt, Gagliardi, L, Giani, I, Giglio, P, Guala, A, Lanari, M, Lippi, F, Lizzoli, C, Lombardi, E, Macchia, Pa, Magnini, M, Memmini, G, Mesirca, P, Micheletti, E, Migliozzi, L, Nunziata, F, Pecile, P, Pepe, G, Perferi, G, Peris, A, Perri, Pf, Pescollderungg, L, Pezzati, M, Poggi, Giovanni Maria, Prato, R, Principi, N, Rapisardi, G, Regoli, M, Riva, A, Rizzo, L, Roman, B, Toffolo, A, Strano, M, Trapani, Sandra, Vasarri, P, Vascotto, M, Vecchi, V, Ventura, A, Verini, M, Zorzi, C., Azzari, Chiara, Moriondo, Maria, Cortimiglia, Martina, Valleriani, Claudia, Canessa, Clementina, Indolfi, Giuseppe, Ricci, Silvia, Nieddu, Francesco, de Martino, Maurizio, Resti, Massimo, Italian group for the study of Invasive Pneumococcal Disease [, Lanari, Marcello, and ]

Subjects
Pneumococcal Vaccine, Male, Serotype, medicine.medical_specialty, Adolescent, Sepsi, Vaccination schedule, Longitudinal Studie, Bacteremia, Real-Time Polymerase Chain Reaction, medicine.disease_cause, Pneumococcal Vaccines, Sepsis, Internal medicine, Streptococcus pneumoniae, medicine, Humans, Longitudinal Studies, Serotyping, Child, Vaccines, Conjugate, Bacterial disease, General Veterinary, General Immunology and Microbiology, Meningitis, Pneumococcal, business.industry, Public Health, Environmental and Occupational Health, Infant, medicine.disease, Pneumonia, Infectious Diseases, Italy, Child, Preschool, Pneumococcal pneumonia, Immunology, Molecular Medicine, Female, business, Meningitis, Human
Abstract

Background and aim of the work Since the introduction of the 7-valent vaccine, invasive pneumococcal disease have greatly decreased; however, changes in the distribution of pneumococcal serotypes have recently highlighted the need for vaccines with wider coverage. The aim of the work was to assess the potential serotype coverage of three pneumococcal conjugate vaccines (7-, 10- and 13-valent) against bacteremic pneumococcal pneumonia and meningitis/sepsis in Italian children. Patients and methods We determined pneumococcal serotypes in immunocompetent patients who had been admitted to hospital with suspicion of invasive bacterial disease and had confirmed bacteremic pneumococcal pneumonia or meningitis/sepsis determined by molecular detection of Streptococcus pneumoniae in a normally sterile site. Positive samples were serotyped using Realtime-PCR. Results Between April 2008 and March 2011, a total of 144 patients (age median 4.1 years; Interquartile range 1.8–5.6) with pneumococcal meningitis/sepsis (n = 43) or pneumonia (n = 101) from 83 participating centers located in 19 of 20 Italian regions were serotyped. The 10 most prevalent serotypes were 1 (29.9%), 3 (16.0%), 19A (13.2%), 7F (8.3%), 5 (4.2%), 14 (4.2%), 6A (3.5%), 6B (3.5%), 18C (3.5%), 19F (3.5%). Overall, serotype coverage for PCV-7, -10 and -13 were respectively 19.4%, 61.8% and 94.4% with no statistical difference between pneumonia and meningitis/sepsis. Potential coverage was similar for children 0–2 or 2–5 years of age. Cultures resulted positive in 35/99 (35.4%) samples simultaneously obtained for both culture and RT-PCR. Conclusion These findings indicate that increasing the potential serotype coverage by introducing PCV13 in the vaccination schedule for infancy could provide substantial added benefit for protection from pneumococcal pneumonia or meningitis/sepsis in Italy in children below 2 years as well in older children. The importance of molecular methods for diagnosis and serotyping of invasive pneumococcal disease was confirmed.

Published
2012

28. Pediatric tuberculosis in Italian children: Epidemiological and clinical data from the Italian register of pediatric tuberculosis

Author

Galli, Lavinia Maddalena, Lancella, L., Tersigni, Chiara, Venturini, Elena, Chiappini, Elisabetta, Bergamini, B., Codifava, M., Venturelli, Chiara, Tosetti, Giovanni, Marabotto, C., Cursi, L., Boccuzzi, E., Garazzino, S., Tovo, P., Pinon, M., Serre, D., Castiglioni, L., Vecchio, A., Guarino, A., Bruzzese, E., Losurdo, G., Castagnola, E., Bossi, Giuliana, Marseglia, G., Esposito, S., Bosis, S., Grandolfo, R., Fiorito, V., Valentini, Piero, Buonsenso, Danilo, Domenici, R., Montesanti, M., Salvini, F., Riva, E., Dodi, I., Maschio, F., Abbagnato, L., Fiumana, E., Fornabaio, C., Ballista, P., Portelli, V., Bottone, G., Palladino, N., Valenzise, M., Vecchi, B., Gangi, M., Lupi, C., Villani, Andrea, De Martino, M., Galli L., Tersigni C., Venturini E., Chiappini E. (ORCID:0000-0002-9782-0712), Venturelli C., Tosetti G., Bossi G., Valentini P. (ORCID:0000-0001-6095-9510), Buonsenso D., Villani A., Galli, Lavinia Maddalena, Lancella, L., Tersigni, Chiara, Venturini, Elena, Chiappini, Elisabetta, Bergamini, B., Codifava, M., Venturelli, Chiara, Tosetti, Giovanni, Marabotto, C., Cursi, L., Boccuzzi, E., Garazzino, S., Tovo, P., Pinon, M., Serre, D., Castiglioni, L., Vecchio, A., Guarino, A., Bruzzese, E., Losurdo, G., Castagnola, E., Bossi, Giuliana, Marseglia, G., Esposito, S., Bosis, S., Grandolfo, R., Fiorito, V., Valentini, Piero, Buonsenso, Danilo, Domenici, R., Montesanti, M., Salvini, F., Riva, E., Dodi, I., Maschio, F., Abbagnato, L., Fiumana, E., Fornabaio, C., Ballista, P., Portelli, V., Bottone, G., Palladino, N., Valenzise, M., Vecchi, B., Gangi, M., Lupi, C., Villani, Andrea, De Martino, M., Galli L., Tersigni C., Venturini E., Chiappini E. (ORCID:0000-0002-9782-0712), Venturelli C., Tosetti G., Bossi G., Valentini P. (ORCID:0000-0001-6095-9510), Buonsenso D., and Villani A.

Abstract

Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. A multicenter study was conducted in 27 pediatric hospitals, pediatric wards, and public health centers in Italy using a standardized form, covering the period of time between 1 January 2010 and 31 December 2012. Children with active TB, latent TB, and those recently exposed to TB or recently adopted/immigrated from a high TB incidence country were enrolled. Overall, 4234 children were included; 554 (13.1%) children had active TB, 594 (14.0%) latent TB and 3086 (72.9%) were uninfected. Among children with active TB, 481 (86.8%) patients had pulmonary TB. The treatment of active TB cases was known for 96.4% (n = 534) of the cases. Overall, 210 (39.3%) out of these 534 children were treated with three and 216 (40.4%) with four first-line drugs. Second-line drugs where used in 87 (16.3%) children with active TB. Drug-resistant strains of Mycobacterium tuberculosis were reported in 39 (7%) children. Improving the surveillance of childhood TB is important for public health care workers and pediatricians. A non-negligible proportion of children had drug-resistant TB and was treated with second-line drugs, most of which are off-label in the pediatric age. Future efforts should concentrate on improving active surveillance, diagnostic tools, and the availability of antitubercular pediatric formulations, also in low-endemic countries.

Published
2016

29. The molecular characterisation of depurinated trial DNA sample can be a model to understand the reliability of the results in forensic genetics

Author

Fattorini, P., Previdere`, C., Sorçaburu Cigliero, S., Marrubini, G., Alù, M., Barbaro, A., Carnevali, E., Carracedo, A., Casarino, L., Consoloni, L., Corato, S., Domenici, R., Fabbri, M., Giardina, E., Grignani, P., Lonero Baldassarra, S., Moratti, M., Pelotti, S., Piccinini, A., Pitacco, P., Plizza, L., Resta, N., Ricci, U., Robino, C., Salvaderi, L., Scarnicci, F., Schneider, P. M., Seidita, G., Trizzino, L., Turchi, C., Turrina, Stefania, Vatta, P., Vecchiotti, C., Verzeletti, A., and De Stefano, F.

Subjects
DNA depurination, Forensic genetics, PCR fidelity, STR typing
Published
2014

30. Results of GeFI's (The Italian Forensic gentics) collaborative exercise on three miniSTR loci (NC01)

Author

Toni C., Alù M., Caenazzo L., Carnevali E., Cerri N., Domenici R., Piccinini A. previderè C. Ricci U., Robino C., Tagliabracci A., venturi M., Presciuttini S., PELOTTI, SUSI, NIELS MORLING (EDITED BY), Toni C., Alù M., Caenazzo L., Carnevali E., Cerri N., Domenici R., pelotti S., Piccinini A. previderè C. Ricci U., Robino C., Tagliabracci A., venturi M., and Presciuttini S.

Published
2008

31. The 2011 GeFI collaborative exercise. Concordance study, proficiency testing and Italian population data on the new ENFSI/EDNAP loci D1S1656, D2S441, D10S1248, D12S391, D22S1045

Author

Previderè, C., Grignani, P., Alessandrini, F., Alù, M., Biondo, R., Boschi, I., Caenazzo, L., Carboni, I., Carnevali, E., De Stefano, F., Domenici, R., Fabbri, M., Giardina, E., Inturri, S., Pelotti, S., Piccinini, A., Piglionica, M., Resta, N., Turrina, S., Verzeletti, A., and Presciuttini, S.

Published
2013
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33. Development of a heptaplex PCR system to analyse X-chromosome STR loci from five Italian population samples. A collaborative study

Author

BINI, CARLA, CECCARDI, STEFANIA, FERRI, GIANMARCO, PELOTTI, SUSI, Alù M., Roncaglia E., Beduschi G., Caenazzo L., Ponzano E., Tasinato P., Turchi C., Mazzanti M., Buscemi L., Tagliabracci A., Toni C., Spinetti I., Domenici R., Presciuttini S., Bini C., Ceccardi S., Ferri G., Pelotti S., Alù M., Roncaglia E., Beduschi G., Caenazzo L., Ponzano E., Tasinato P., Turchi C., Mazzanti M., Buscemi L., Tagliabracci A., Toni C., Spinetti I., Domenici R., and Presciuttini S.

Subjects
Male, POPULATION SAMPLE, Chromosomes, Human, X, multiplex PCR, X-chromosome, population data, MUTATION RATES, DNA Fingerprinting, Polymerase Chain Reaction, KINSHIP ANALYSIS, Genetics, Population, Gene Frequency, Haplotypes, Italy, Tandem Repeat Sequences, X-CHROMOSOME, Humans, Female, ALLELE FREQUENCIES
Abstract

Many X-chromosome short tandem repeats (X-STRs) have been validated for forensic use even if further studies are needed on allele frequencies and mutation rates to evaluate the extent of polymorphism in different populations and to establish reference databases useful for forensic applications and for anthropological studies. A single multiplex reaction of seven X-STRs, which includes the DXS6789, HUMARA, DXS10011, DXS7423, HPRTB, DXS6807, DXS101 loci, is presented and their allele frequency distribution in a large population sample including 556 subjects (268 females and 288 males) analysed by five forensic laboratories of Central and Northern Italy is shown. Our results demonstrate the feasibility of a single amplification/detection reaction involving seven markers of the X chromosome, which can be fruitfully used in complex kinship analysis.

Published
2005

34. Distribution of invasive meningococcal B disease in Italian pediatric population: implications for vaccination timing

Author

Azzari, Chiara, Canessa, Clementina, Lippi, Francesca, Moriondo, Maria, Indolfi, Giuseppe, Nieddu, Francesco, Martini, Marco, de Martino, Maurizio, Castiglia, Paolo, Baldo, Vincenzo, Resti, Massimo, Agostiniani, R., Allievi, P., Allù, G., Amigoni, A., Bartolini, E., Bernardi, Francesco, Bernardini, SOFIA ROBERTA, Biban, P., Bigi, M., Bossi, G., Bottone, U., Cardinale, A., Cardona, A., Castronari, R., Celandroni, A., Chiossi, M., Colleselli, P., Correra, A., Cortimiglia, M., D'Ascola, G., De Benedictis, F. M., de Martino, M., Dini, E., Dollfus, L., Domenici, R., Flacco, V., Verrotti, A., Gaetti, M. T., Gagliardi, L., Galli, Lorenzo, Giglio, P., Guala, A., Lanari, M., Lasagni, D., Lizzoli, C., Lombardi, E., Magnini, M., Mattei, R., Memmini, G., Mesirca, P., Gragnani, S., Migliozzi, L., Nunziata, F., Pecile, P., Pepe, G., Perferi, G., Peris, A., Perri, P. F., Pescollderungg, L., Pezzati, M., Poggi, G. M., Poggiolesi, C., Rapisardi, G., Ratta, L., Ricci, S., Ridi, F., Riva, MARCO ANDREA, Rizzo, L., Roman, B., Romano, F., Toffolo, A., Strano, M., Trapani, S., Valleriani, C., Vasarri, P., Vascotto, M., Vergine, G., Verini, M., Zorzi, C., Azzari, Chiara, Canessa, Clementina, Lippi, Francesca, Moriondo, Maria, Indolfi, Giuseppe, Nieddu, Francesco, Martini, Marco, de Martino, Maurizio, Castiglia, Paolo, Baldo, Vincenzo, Resti, Massimo, Italian Group for the Study of Invasive Bacterial Disease [, Lanari M., and ]

Subjects
Pediatrics, Children, Incidence, Neisseria meningitidis group B, Realtime PCR, Sensitivity, Vaccine, Adolescent, Age Distribution, Child, Child, Preschool, Hospitals, Pediatric, Humans, Immunization Schedule, Infant, Infant, Newborn, Italy, Meningitis, Meningococcal, Meningococcal Vaccines, Real-Time Polymerase Chain Reaction, Retrospective Studies, Sepsis, Neisseria meningitidis, Serogroup B, Molecular Medicine, Immunology and Microbiology (all), Veterinary (all), Public Health, Environmental and Occupational Health, Infectious Diseases, Disease, Neisseria meningitidis, medicine.disease_cause, Group B, Epidemiology, Medicine, Pediatric, Meningococcal, Incidence (epidemiology), Hospitals, Vaccination, Public Health, Meningitis, medicine.medical_specialty, Serogroup B, Immunology and Microbiology(all), MED/42 Igiene generale e applicata, Preschool, General Veterinary, General Immunology and Microbiology, business.industry, Environmental and Occupational Health, medicine.disease, Newborn, veterinary(all), business
Abstract

Neisseria meningitidis group B (MenB) is a leading cause of meningitis and sepsis. A new vaccine has been recently licensed. The aim of the present study was to evaluate the epidemiology of MenB disease in pediatric age and define the optimal age for vaccination. All patients aged 0–18 years admitted with a diagnosis of meningitis or sepsis to the 83 participating Italian pediatric hospitals were included in the study. Blood and/or cerebrospinal fluid (CSF) samples were tested by Realtime-PCR and/or culture. One hundred and thirty-six cases (mean age 5.0 years, median 2.7) of MenB disease were found. Among these, 96/136 (70.6%) were between 0 and 5 years, 61/136 (44.9%) were between 0 and 2 years. Among the latter, 39/61 (63.9%) occurred during the first year of life with highest incidence between 4 and 8 months. A case-fatality rate of 13.2% was found, with 27.8% cases below 12 months. Sepsis lethality was 24.4%. RT-PCR was significantly more sensitive than culture: 82 patients were tested at the same time by both methods, either in blood or in CSF; MenB was found by RT-PCR in blood or CSF in 81/82 cases (98.8%), culture identified 27/82 (32.9%) infections (Cohen's Kappa 0.3; McNemar's: p < 10−5). The study shows that the highest incidence of disease occurs in the first year of age, with a peak between 4 and 8 months of life; 30% of deaths occur before 12 months. The results suggest that the greatest prevention could be obtained starting MenB vaccination in the first months of life; a catch-up strategy up to the fifth year of life could be considered. Our results also confirm that Realtime PCR is significantly more sensitive than culture. In those countries where only isolate positive infections are counted as cases, the incidence of MenB infection results highly underestimated.

Published
2013

37. Community‐acquired bacteremic pneumococcal pneumonia in children: diagnosis and serotyping by real‐time polymerase chain reaction using blood samples

Author

Resti, M., Moriondo, M., Cortimiglia, M., Indolfi, G., Canessa, C., Becciolini, L., Bartolini, E., De Benedictis, F. M., De Martino, M., Azzari, C., Agostiniani, R, Allievi, P, Allù, G, Amigoni, A, Baldo, E, Barlocco, G, Bernardi, P, Bernardini, R, Biban, P, Bossi, G, Bottone, U, Cardinale, A, Cardona, A, Castelli Gattinara, G, Celandroni, A, Chiossi, M, Colleselli, P, Correra, A, D'Ascola, G, D'Aquino, A, Dollfus, L, Domenici, R, Flacco, V, Furbetta, M, Gaetti, Mt, Gagliardi, L, Ghiori, F, Giani, I, Giglio, P, Guala, A, Icardi, G, Lanari, M, Lippi, F, Lizzoli, C, Lombardi, E, Macchia, Pa, Magnini, M, Memmini, G, Mesirca, P, Micheletti, E, Migliozzi, L, Nunziata, F, Osimani, P, Paravati, D, Pecile, P, Pepe, G, Peris, A, Perri, Pf, Pescollderungg, L, Pezzati, M, Poggi, Gm, Poggiolesi, C, Prato, R, Principi, N, Rapisardi, G, Ridi, F, Riva, A, Rizzo, L, Roman, B, Toffolo, A, Strano, M, Trapani, S, Vasarri, P, Vascotto, M, Vecchi, V, Ventura, A, Verini, M, Zorzi, C., Resti, Massimo, Moriondo, Maria, Cortimiglia, Martina, Indolfi, Giuseppe, Canessa, Clementina, Becciolini, Laura, Bartolini, Elisa, de Benedictis, Fernando Maria, de Martino, Maurizio, Azzari, Chiara, Italian Group for the, Study of Invasive Pneumococcal Disease, and Lanari, M.

Subjects
Microbiology (medical), Male, medicine.medical_specialty, Adolescent, Bacteremia, medicine.disease_cause, Polymerase Chain Reaction, Parapneumonic effusion, Community-acquired pneumonia, Bacterial Typing Technique, Internal medicine, Streptococcus pneumoniae, medicine, Humans, Community-Acquired Infection, Serotyping, Preschool, Child, business.industry, Bacterial pneumonia, Infant, Newborn, Infant, Odds ratio, Pneumonia, Pneumonia, Pneumococcal, medicine.disease, Newborn, Bacterial Typing Techniques, Community-Acquired Infections, Infectious Diseases, Blood, Italy, Child, Preschool, Pneumococcal pneumonia, Immunology, Pneumococcal, Female, business, Human
Abstract

Background. The aim of this study was to use real-time polymerase chain reaction (RT-PCR) on blood samples to diagnose and serotype pneumococcal infection in a large cohort of Italian children hospitalized for community-acquired pneumonia. Methods. We conducted an observational study from April 2007 through June 2009 of children aged 0-16 years with a diagnosis of community-acquired pneumonia admitted to 83 pediatric hospitals in Italy. Results. Seven hundred fifty-three children were studied. RT-PCR found pneumococcal infection in 80 (10.6%) of 753 patients. In 292 patients, culture and RT-PCR were simultaneously performed. Streptococcus pneumoniae was identified in 47 of 292 patients; 45 (15.4%) tested positive by RT-PCR and 11 (3.8%) tested positive by culture. RT-PCR was significantly more sensitive than culture in revealing bacteremic pneumonia (odds ratio, 30.6; 95% confidence interval, 5.8-97.5; P < .001). Complicated pneumonia was found in 162 (21.5%) of 753 children; 152 (93.8%) of these 162 had parapneumonic effusion, and 51 (33.6%) had empyema. Children with complicated pneumonia were significantly older. Pneumococcal bacteremia was found by RT-PCR to occur significantly more frequently in children with complications (38 [23.5%] of 162) than in children with uncomplicated pneumonia (44 [7.4%] of 591; odds ratio, 3.8; 95% confidence interval, 2.30-6.30; P

Published
2010

38. Whiplash-Associated Disorders

Author

Ferrara, S. D., primary, Ananian, V., additional, Baccino, E., additional, Banczerowski, P., additional, Bordignon, D., additional, Boscolo-Berto, R., additional, Domenici, R., additional, Gorriz Quevedo, J., additional, Graw, M., additional, Hell, W., additional, Hernandez Cueto, C., additional, Knudsen, P. J. T., additional, Masiero, S., additional, Montisci, M., additional, Norelli, G. A., additional, Pinchi, V., additional, Raudys, R., additional, Raul, J. S., additional, Sterzik, V., additional, Tessitore, E., additional, Tuusov, J., additional, Vanezis, P., additional, Vermylen, Y., additional, Vieira, D. N., additional, Viel, G., additional, Viero, A., additional, Villanueva, E., additional, and Zoia, R., additional

Published
2015
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39. Elementi di Medicina Legale

Author

Bertol, E., Catanesi, R., Crinò, C., Danesino, P., DE LEO, Domenico, Dell'Osso, G., Domenici, R., Gabrielli, M., Introna, F., Lo Menzo, G., Mari, F., Ricci, P., Rodriguez, D., and Tagliabracci, A.

Subjects
Deontologia medica, Medicina Legael, Responsabilità professionale
Published
2010

40. The population genetic structure of Y chromosomes in 1338 italians

Author

Onofri, V., Buscemi, L., Caenazzo, L., Capelli, C., Carnevali, E., Cerri, N., Di Gaetano, C., Domenici, R., Ferri, G., Nutini, L., Pelotti, S., Previderè, C., Robino, C., Scarnicci, F., Fabbri, Matteo, Seidita, G., Roewer, L., Tagliabracci, A., and the GeFi Group

Published
2010

41. Allele frequency of HumvWA31 locus in Italy. Report of the GEFI collaborative study 'Ancona 1'

Author

Buscemi, L, Santese, B, Pelotti, S, Cerri, N, Pasqui, G, Ricci, U, DE STEFANO, F, Asmundo, A, Bogoni, A, Alù, M, DE ROBERTIS M, SACCHETTI L., Cossu, G, Caenazzo, L, Procaccianti, S, Cucurachi, N, Previdere', C, Domenici, R, D'Aloja, E, Vecchiotti, C, Sancasciani, A, Carnevali, E, Fattorini, Paolo, Buscemi, L, Santese, B, Pelotti, S, Cerri, N, Pasqui, G, Ricci, U, DE STEFANO, F, Asmundo, A, Bogoni, A, Alù, M, SACCHETTI L., DE ROBERTIS M, Cossu, G, Caenazzo, L, Procaccianti, S, Cucurachi, N, Previdere', C, Domenici, R, D'Aloja, E, Vecchiotti, C, Sancasciani, A, Carnevali, E, and Fattorini, Paolo

Published
1998

42. Collaborative study on the polymorphism of the D1S80 locus in the italian population

Author

Alu', M, Asmundo, A, Carnevali, E, Cerri, N, Cortivo, P, Cucurachi, N, D'Aloja, E, DE FERRARI, F, DE STEFANO, F, DI NUNNO, C, Domenici, R, Fattorini, Paolo, Florian, Fiorella, Pappalardo, G, Pasqui, G, Peloso, G, Pelotti, S, Pignatti, P. F., Porfirio, B, Previdere', C, Ricci, U, Scimmi, D, Sciacca, G, Suadoni, F, Tagliabracci, A, Trabetti, E, Venturi, M., Alu', M, Asmundo, A, Carnevali, E, Cerri, N, Cortivo, P, Cucurachi, N, D'Aloja, E, DE FERRARI, F, DE STEFANO, F, DI NUNNO, C, Domenici, R, Fattorini, Paolo, Florian, Fiorella, Pappalardo, G, Pasqui, G, Peloso, G, Pelotti, S, PIGNATTI P., F, Porfirio, B, Previdere', C, Ricci, U, Scimmi, D, Sciacca, G, Suadoni, F, Tagliabracci, A, Trabetti, E, and Venturi, M.

Published
1996

43. The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age

Author

CATASSI C, FABIANI E, RATSH IM, COPPA GV, GIORGI PL, PIERDOMENICO R, ALESSANDRINI S, IWANEJKO G, DOMENICI R, MEI E, MIANO A, MARANI M, BOTTARO G, SPINA M, DOTTI M, MONTANELLI A, BARBATO M, VIOLA F, LAZZARI R, VALLINI M, GUARISO G, PLEBANI M, CATALDO F, TRAVERSO G, VENTURA, ALESSANDRO, Catassi, C, Fabiani, E, Ratsh, Im, Coppa, Gv, Giorgi, Pl, Pierdomenico, R, Alessandrini, S, Iwanejko, G, Domenici, R, Mei, E, Miano, A, Marani, M, Bottaro, G, Spina, M, Dotti, M, Montanelli, A, Barbato, M, Viola, F, Lazzari, R, Vallini, M, Guariso, G, Plebani, M, Cataldo, F, Traverso, G, and Ventura, Alessandro

Abstract

ACTA PAEDIATR SUPPL

Published
1996

48. Inferring relationships between pairs of individuals from locus heterozygosities

Author

Presciuttini, S., Toni, C., Tempestini, E., Verdiani, S., Casarino, L., Spinetti, I., Stefano, F., Domenici, R., and Joan Bailey-Wilson

Subjects
Genetic Markers, Male, Models, Statistical, lcsh:QH426-470, Genetic Carrier Screening, Siblings, Genetic Variation, Paternity, DNA Fingerprinting, White People, Nuclear Family, lcsh:Genetics, Genetics, Population, Gene Frequency, Tandem Repeat Sequences, Humans, Female, Research Article
Abstract

Background The traditional exact method for inferring relationships between individuals from genetic data is not easily applicable in all situations that may be encountered in several fields of applied genetics. This study describes an approach that gives affordable results and is easily applicable; it is based on the probabilities that two individuals share 0, 1 or both alleles at a locus identical by state. Results We show that these probabilities (zi) depend on locus heterozygosity (H), and are scarcely affected by variation of the distribution of allele frequencies. This allows us to obtain empirical curves relating zi's to H for a series of common relationships, so that the likelihood ratio of a pair of relationships between any two individuals, given their genotypes at a locus, is a function of a single parameter, H. Application to large samples of mother-child and full-sib pairs shows that the statistical power of this method to infer the correct relationship is not much lower than the exact method. Analysis of a large database of STR data proves that locus heterozygosity does not vary significantly among Caucasian populations, apart from special cases, so that the likelihood ratio of the more common relationships between pairs of individuals may be obtained by looking at tabulated zi values. Conclusions A simple method is provided, which may be used by any scientist with the help of a calculator or a spreadsheet to compute the likelihood ratios of common alternative relationships between pairs of individuals.

Published
2002

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