109 results on '"Dizdar N"'
Search Results
2. Clinical behaviour of papillary thyroid cancer oncocytic variant: stage-matched comparison versus classical and tall cell variant papillary thyroid cancer
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Okuyucu, K., Ince, S., Cinar, A., San, H., Samsum, M., Dizdar, N., Alagoz, E., Demirci, I., Ozkara, M., Gunalp, B., and Karaçalıoglu, A.O.
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- 2023
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3. A huge adrenocortical carcinoma mimicking liver mass
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Aydinbelge-Dizdar, N., Cayir, D., Canlar, S., Celik, E.N., and Cakal, E.
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- 2024
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4. Comportamiento clínico de la variante oncocítica del cáncer papilar de tiroides: comparación de su evolución frente al cáncer papilar, variantes clásica y de células altas
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Okuyucu, K., primary, Ince, S., additional, Cınar, A., additional, San, H., additional, Samsum, M., additional, Dizdar, N., additional, Alagoz, E., additional, Demirci, I., additional, Ozkara, M., additional, Gunalp, B., additional, and Karaçalıoglu, A.O., additional
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- 2022
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5. Comportamiento clínico de la variante oncocítica del cáncer papilar de tiroides: comparación de su evolución frente al cáncer papilar, variantes clásica y de células altas.
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Okuyucu, K., Ince, S., Cınar, A., San, H., Samsum, M., Dizdar, N., Alagoz, E., Demirci, I., Ozkara, M., Gunalp, B., and Karaçalıoglu, A.O.
- Abstract
El cáncer papilar de tiroides (CPT) tiene diferentes variantes y la mayoría de ellas presentan diferencias sutiles. La variante oncocítica (VO) es un subtipo poco frecuente de CPT, sobre el pronóstico de la cual existen resultados controvertidos en la literatura. Investigamos su agresividad y curso clínico comparándolos con la variante clásica (VC) y la variante de células altas (CA) de CPT en diferentes estadios. En este estudio de cohortes retrospectivo se incluyeron: 100 muestras simples de VO, 71 de CA y 1.219 de VC. Las muestras VO se compararon con las VC y las de CA sobre la base de parámetros de pronóstico independientes. La recurrencia de la VO también se comparó estadio por estadio con la VC y CA. La edad media fue de 46,8 años y la relación hombres/mujeres de 25/75 para la VO. Las tasas de recurrencia en nuestro estudio fueron del 16% en VO; del 13,5% en VC y del 56% en CA. Existe una diferencia estadísticamente significativa con respecto a la recurrencia entre el estadio 1 y el estadio 4 comparando la VO y la VC (p = 0,023; p = 0,03, respectivamente). También hay una diferencia estadísticamente significativa con respecto a la recurrencia entre el estadio 1 y el estadio 4 comparando la VO y la CA (p = 0,001; p = 0,024, respectivamente). Se puede suponer que la VO tiene un comportamiento entre la VC y la CA, pero muy cercana a la CA. La VO parece ser un poco más agresiva que la VC. A pesar de un tamaño de muestra inadecuado para los estadios 2 y 3, nuestros hallazgos implican un mayor riesgo de recurrencia para la VO que para la VC en los estadios avanzados (estadios 3 y 4) y la VC tiene un pronóstico más desfavorable que VO en estadios precoces (estadios 1 y 2), según el modelo de estadio pareado. Papillary thyroid cancer (PTC) has many variants and most of them are mild tumors. Oncocytic variant (OV) is a rare subtype of PTC. There are controversial results about its prognosis in the literature. We investigated its aggressivity and clinical course by comparing it with classical variant (CV) and tall cell variant (TV) of PTC over a stage-matched design. Pure 100 OV, 71 TV and 1,219 CV were included in this retrospective cohort study. OV was compared with CV and TV according to independent prognostic parameters. OV was also compared stage by stage with CV and TV for recurrence. Mean age was 46,8 years and male/female ratio 25/75 for OV. The recurrence rates in our study were 16% in OV, 13,5% in CV and 56% in TV. There is a statistically significant difference according to recurrence between stage 1 and stage 4 OV and CV (P = 0.023, P = 0.03, respectively). There is also a statistically significant difference between stage 1 and stage 4 OV and TV according to recurrence (P = 0.001, P = 0.024, respectively). OV can be supposed to behave between CV and TV, but very closer to CV. OV seems to be slightly more aggressive than CV. Despite an inadequate sample size for stage 2 and 3, our findings imply an increased recurrence risk for OV than CV at the advanced stages (stage 3 and 4) and CV has an unfavorable prognosis than OV at early stages (stage 1 and 2) according to stage-matched model. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Dose–hair concentration relationship and pigmentation effects in patients on low-dose clozapine
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Kronstrand, R., Roman, M., Hedman, M., Ahlner, J., and Dizdar, N.
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- 2007
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7. Interim analysis of long-term intraduodenal levodopa infusion in advanced Parkinson disease
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Pålhagen, S. E., Dizdar, N., Hauge, T., Holmberg, B., Jansson, R., Linder, J., Nyholm, D., Sydow, O., Wainwright, M., Widner, H., and Johansson, A.
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- 2012
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8. SUCCESSFUL PLASMA EXCHANGE TREATMENT OF MULTIFOCAL MYOCLONUS. TWO CASE HISTORIES: p534
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Gati, I., Danielsson, O., Leijon, G., Szekeres, V., Dizdar, N., Gauffin, H., and Vrethem, M.
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- 2012
9. A Scandinavian multi-centre study replicates 11 susceptibility loci from genome-wide association studies in Parkinsonʼs disease: SC137
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Pihlstrøm, L., Bjørnarå, K.-A., Dizdar, N., Fardell, C., Forsgren, L., Holmberg, B., Larsen, J. P., Linder, J., Nissbrandt, H., Tysnes, O.-B., Dietrichs, E., and Toft, M.
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- 2012
10. Comparison of apomorphine and levodopa infusions in four patients with Parkinsonʼs disease with symptom fluctuations
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Nyholm, D., Constantinescu, R., Holmberg, B., Dizdar, N., and Askmark, H.
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- 2009
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11. L-Dopa pharmacokinetics studied with microdialysis in patients with Parkinson's disease and a history of malignant melanoma
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Dizdar, N., Granérus, A.-K., Hannestad, U., Kullman, A., Ljungdahl, Å., Olsson, J.-E., and Kågedal, B.
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- 1999
12. Consensus statement from the 2014 International Microdialysis Forum
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Hutchinson, PJ, Jalloh, I, Helmy, A, Carpenter, KL, Rostami, E, Bellander, BM, Boutelle, MG, Chen, JW, Claassen, J, Dahyot-Fizelier, C, Enblad, P, Gallagher, CN, Helbok, R, Hillered, L, Le Roux, PD, Magnoni, S, Mangat, HS, Menon, DK, Nordström, CH, O'Phelan, KH, Oddo, M, Perez Barcena, J, Robertson, C, Ronne-Engström, E, Sahuquillo, J, Smith, M, Stocchetti, N, Belli, A, Carpenter, TA, Coles, JP, Czosnyka, M, Dizdar, N, Goodman, JC, Gupta, AK, Nielsen, TH, Marklund, N, Montcriol, A, O'Connell, MT, Poca, MA, Sarrafzadeh, A, Shannon, RJ, Skjøth-Rasmussen, J, Smielewski, P, Stover, JF, Timofeev, I, Vespa, P, Zavala, E, Ungerstedt, U, Columbia University [New York], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Cambridge, Wolfson Brain Imaging Centre, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Addenbrooke's Hospital, Cambridge University NHS Trust, Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Hutchinson, Peter [0000-0002-2796-1835], Helmy, Adel [0000-0002-0531-0556], Carpenter, Keri [0000-0001-8236-7727], Menon, David [0000-0002-3228-9692], Carpenter, Adrian [0000-0002-2939-8222], Coles, Jonathan [0000-0003-4013-679X], Czosnyka, Marek [0000-0003-2446-8006], Smielewski, Peter [0000-0001-5096-3938], Apollo - University of Cambridge Repository, and Wellcome Trust
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Microdialysis ,Conference Reports and Expert Panel ,[SDV]Life Sciences [q-bio] ,Clinical Sciences ,humanos ,Public Health And Health Services ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,Critical Care and Intensive Care Medicine ,Emergency & Critical Care Medicine ,Brain chemistry ,microdiálisis ,Traumatic brain injury ,guías de práctica clínica como asunto ,Practice Guidelines as Topic ,Humans ,Subarachnoid hemorrhage ,ComputingMilieux_MISCELLANEOUS ,Outcome - Abstract
Microdialysis enables the chemistry of the extracellular interstitial space to be monitored. Use of this technique in patients with acute brain injury has increased our understanding of the pathophysiology of several acute neurological disorders. In 2004, a consensus document on the clinical application of cerebral microdialysis was published. Since then, there have been significant advances in the clinical use of microdialysis in neurocritical care. The objective of this review is to report on the International Microdialysis Forum held in Cambridge, UK, in April 2014 and to produce a revised and updated consensus statement about its clinical use including technique, data interpretation, relationship with outcome, role in guiding therapy in neurocritical care and research applications., We gratefully acknowledge financial support for participants as follows: P.J.H.-National Institute for Health Research (NIHR) Professorship and the NIHR Biomedical Research Centre, Cambridge; I.J. Medical Research Council (G1002277 ID 98489); A. H.-Medical Research Council, Royal College of Surgeons of England; K.L.H.C.-NIHR Biomedical Research Centre, Cambridge (Neuroscience Theme; Brain Injury and Repair Theme); M.G.B.-Wellcome Trust Dept Health Healthcare Innovation Challenge Fund (HICF-0510-080); L. H.-The Swedish Research Council, VINNOVA and Uppsala Berzelii Technology Centre for Neurodiagnostics; S. M.-Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico; D.K.M.-NIHR Senior Investigator Award to D.K.M., NIHR Cambridge Biomedical Research Centre (Neuroscience Theme), FP7 Program of the European Union; M. O.-Swiss National Science Foundation and the Novartis Foundation for Biomedical Research; J.S.-Fondo de Investigacion Sanitaria (Instituto de Salud Carlos III) (PI11/00700) co-financed by the European Regional Development; M.S.-NIHR University College London Hospitals Biomedical Research Centre; N. S.-Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico.
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- 2015
13. Interim analysis of long-term intraduodenal levodopa infusion in advanced Parkinson disease
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Pålhagen, S E, Dizdar, N, Hauge, T, Holmberg, B, Jansson, R, Linder, J, Nyholm, Dag, Sydow, O, Wainwright, M, Widner, H, Johansson, Anders, Pålhagen, S E, Dizdar, N, Hauge, T, Holmberg, B, Jansson, R, Linder, J, Nyholm, Dag, Sydow, O, Wainwright, M, Widner, H, and Johansson, Anders
- Abstract
BACKGROUND: This interim 12-month analysis is a part of an open-label, observational, prospective study on health outcomes and cost impact of levodopa/carbidopa intestinal gel (LCIG, Duodopa) in Parkinson disease (PD). The specific aim was to investigate clinical and health-related quality of life (HRQoL) effects in routine care. METHODS: Unified PD rating scale (UPDRS) was the primary efficacy measurement. PD QoL questionnaire 39 (PDQ-39) assessed HRQoL. Subjects were assessed at baseline, ≥3 months after surgery, and then every 3 months. RESULTS: Twenty-seven treatment-naïve subjects when started with LCIG showed a decrease in UPDRS score that was statistically significant throughout the year: UPDRS total score (mean ± SD), baseline = 52.1 ± 16.1, N = 27, month 0 (first visit; at least 3 months after permanent LCIG) = 43.1 ± 16.7, N = 27, P = 0.003; month 12 = 42.5 ± 22.6, n = 25, P = 0.017. PDQ-39 results also showed a tendency for improvement: PDQ-39 (mean ± SD), baseline = 33.6 ± 10.8, N = 27, month 0 = 27.1 ± 11.8, N = 27, P = 0.001; 12 months = 28.8 ± 12.8, n = 23, P = 0.126. CONCLUSIONS: LCIG provides functional improvement beginning at first visit that is sustained for 12 months.
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- 2012
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14. A Scandinavian multi-centre study replicates 11 susceptibility loci from genome-wide association studies in Parkinson's disease
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Pihlstrom, L., Bjornara, K. -A, Dizdar, N., Fardell, C., Forsgren, Lars, Holmberg, B., Larsen, J. P., Linder, Jan, Nissbrandt, H., Tysnes, O. -B, Dietrichs, E., Toft, M., Pihlstrom, L., Bjornara, K. -A, Dizdar, N., Fardell, C., Forsgren, Lars, Holmberg, B., Larsen, J. P., Linder, Jan, Nissbrandt, H., Tysnes, O. -B, Dietrichs, E., and Toft, M.
- Abstract
Special Issue: Abstracts of the 16th Congress of the EFNS, Stockholm, Sweden, 2012
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- 2012
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15. Comparison of apomorphine and levodopa infusions in four patients with Parkinson's disease with symptom fluctuations
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Nyholm, Dag, Constantinescu, R, Holmberg, B, Dizdar, N, Askmark, Håkan, Nyholm, Dag, Constantinescu, R, Holmberg, B, Dizdar, N, and Askmark, Håkan
- Abstract
BACKGROUND: Motor fluctuations in patients with advanced Parkinson's disease may be successfully treated with subcutaneous apomorphine infusion or intraduodenal levodopa/carbidopa infusion. No comparative trials of these two alternatives were performed. AIMS OF THE STUDY: We present a subanalysis from a randomized crossover clinical trial where levodopa infusion as monotherapy was compared with any other combination of pharmacotherapy in fluctuating patients. Four patients used apomorphine infusion and oral levodopa in the comparator arm. The results of these four patients are presented in detail. METHODS: The duration of the trial was 3 + 3 weeks. Patients were video-recorded half-hourly on two non-consecutive days of both treatment arms. Blinded video ratings were used. Patient self-assessments of motor function and quality-of-life (QoL) parameters were captured using an electronic diary. RESULTS: Ratings in moderate to severe "off" state ranged 0-44% on apomorphine infusion and 0-6% on levodopa infusion. Moderate to severe dyskinesias were not recorded in any of the treatments. QoL was reported to be improved in all patients on duodenal levodopa infusion. CONCLUSIONS: Monotherapy with duodenal infusion of levodopa was more efficacious and brought greater QoL than combination therapy with apomorphine infusion in these fluctuating patients.
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- 2009
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16. Devamlı otlanılan ve üç yıldır otlatılmayan meralarda vejetasyon etüdü
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Turcan (Dizdar), N. Mükerreme, Mülayim, Mevlüt, and Diğer
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Ziraat ,Vegetation ,Field crops ,Pasture ,Agriculture - Abstract
Öz Yüksek Lisans Tezi DEVAMLI OTLATILAN ve ÜÇ YILDIR OTLATILMAYAN MERALARDA VEJETASYON ETÜDÜ Naciye M. (DİZDAR) TURCAN Selçuk Üniversitesi Fen Bilimleri Enstitüsü Tarla Bitkileri Anabilim Dalı Danışman: Doç. Dr. Mevlüt MÜLAYİM 1997, Sayfa: 48 Jüri: Doç. Dr. Mevlüt MÜLAYİM Prof. Dr. Ahmet GÖKKUŞ Prof. Dr. Baki EYCE Bu araştırma, 1995 yılında Selçuk Üniversitesi Alaeddin Keykûbat Kampus alanında benzer toprak ve bitki örtüsüne sahip, her yıl otlatılan ve üç yıldır otlatma yapılmayan (otlatmadan korunan) iki mera alanında yapılmıştır. Araştırmada her iki mera için üç ayrı dönemde (otlatma öncesi- 11.4.1995, otlatma sonrası-26.6.1995 ve sonbahar dönemi-20.10.1995) transekt metodu kullanılarak vejetasyon etüdü yapılmıştır. Her iki alanda yapılan vejetasyon çalışmalarında bitki ile kaplı alan. botanik kompozisyon ve bitkilerin tekerrürü tesbit edilmiştir. Otlatılan merada bitki ile kaplı alan üç etüdde sırasıyla; 9r36.66, %29.70, %21.33 ve otlatılmayan merada ise %61.53. %47.35 ve 9M2.43 olarak tesbit edilmiştir.Otlatılan merada üç etüdde botanik kompozisyon değerlerinin ortalamalarına göre %17.70'ini buğdaygiller, %4.72'sini baklagiller ve %77.58'ini diğer familyalara dahil bitkiler teşkil etmiştir. Otlatılmayan merada ise bu oranlar sırasıyla %27.83, %1.87 ve %70.30 olarak bulunmuştur. Araştırma merasında toplam 76 bitki türü tespit edilmiştir. En çok rastlanılan bitkiler Thymus squarrosus Fisch et Mey., Helianthemum nummularium (L.) Mili. ve Festuca ovina L.'dır. ANAHTAR KELİMELER: Vejetasyon Etüdü, Devamlı otlatılan mera, Otlatılmayan mera, Botanik kompozisyon, Bitki ile kaplı alan, Tekerrür. ABSTRACT MSc Thesis A STUDY ON THE PASTURES WHICH WERE UNDER PERMANENT GRAZING AND ON THE PASTURES WHICH WERE NOT GRAZED FOR THREE CONSEQUTIVE YEARS Naciye M. (DİZDAR) TURCAN Selçuk University- Graduate School of Natural and Applied Sciences Department of Field Crops Supervisor: Ass. Prof. Dr. Mevlüt MÜLAYİM 1997, Page: 48 Jury: Ass. Prof. Dr. Mevlüt MÜLAYİM Prof. Dr. Ahmet GÖKKUŞ Prof. Dr. Baki EYCE This study was conducted in main Campus area of Selçuk University in 1995. Two pasture lands were examined on the basis of duration of grazing. Both lands had similar soil and vegetation conditions but they differed in the length of grazin. One pasture land was under continious grazed where as the other was not grazed for there consequtive years. The survery for both pastures continued in three periods (pre-grazing 11.4.1995, post grazing 26.6.1995 and during autumn 20.10.1995) using the transect method. The main factors under study were area covered by plants for three periods on the continiously grazed pasture were %36.66, %29.70 and %21.33 respectively while on pasture which was not grazed for three years, lower values were obterime as %61.53, %47.35 and %42.43.Mean botanical composition of permanently grazed pasture consisted of Gramineae species %17.70, Leguminous species %4.72, and from other families %77.58. While there valves were found as %27.83, %1.87 and %70.30 respectively in pasture land which was not grazed for three years. 76 different plants were determined and Thymus squarrosus Fisch et Mey, Helianthemum nummularium (L.) Mill, and Festuca ovina L. was the most uncountered plants in the study area. KEY WORDS: Vejetation survey, Both grazing area, Ungrazing area, botanical composition, Area covered by plants, Frequency. 48
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- 1997
17. Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease
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Nyholm, Dag, Nilsson Remahl, AIM, Dizdar, N, Constantinescu, R, Holmberg, B, Jansson, R, Aquilonius, Sten-Magnus, Askmark, Håkan, Nyholm, Dag, Nilsson Remahl, AIM, Dizdar, N, Constantinescu, R, Holmberg, B, Jansson, R, Aquilonius, Sten-Magnus, and Askmark, Håkan
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- 2005
18. Simulations and visualizations for interpretation of brain microdialysis data during deep brain stimulation
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Diczfalusy, E., primary, Dizdar, N., additional, Zsigmond, P., additional, Kullman, A., additional, Loyd, D., additional, and Wardell, K., additional
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- 2012
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19. Culturing of diagnostic muscle biopsies as spheroid-like structures: a pilot study of morphology and viability
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Gáti, I., primary, Danielsson, O., additional, Betmark, T., additional, Ernerudh, J., additional, Öllinger, K., additional, and Dizdar, N., additional
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- 2010
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20. L-Dopa pharmacokinetics studied with microdialysis in patients with Parkinson's disease and a history of malignant melanoma
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Dizdar, N., primary, Granérus, A.-K., additional, Hannestad, U., additional, Kullman, A., additional, Ljungdahl, Å., additional, Olsson, J.-E., additional, and Kågedal, B., additional
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- 2009
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21. Treatment of Parkinson's disease with NADH
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Dizdar, N., primary, Kågedal, B., additional, and Lindvall, B., additional
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- 2009
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22. G.P.16.07 Formation and viability of spheroid-like structures in cultures of muscle biopsies. Uptake and characteristics of transport kinetics of 99mTc-Tetrofosmin: Preliminary results
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Gati, I., primary, Danielsson, O., additional, Betmark, T., additional, Ernerudh, J., additional, Ollinger, K., additional, and Dizdar, N., additional
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- 2007
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23. Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient
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Gáti, I., primary, Danielsson, O., additional, Betmark, T., additional, Ernerudh, J., additional, Öllinger, K., additional, and Dizdar, N., additional
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- 2007
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24. Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease
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Nyholm, D., primary, Nilsson Remahl, A. I.M., additional, Dizdar, N., additional, Constantinescu, R., additional, Holmberg, B., additional, Jansson, R., additional, Aquilonius, S. -M., additional, and Askmark, H., additional
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- 2005
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25. Quantitative Analysis of Desmethylselegiline, Methamphetamine, and Amphetamine in Hair and Plasma from Parkinson Patients on Long-Term Selegiline Medication
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Kronstrand, R., primary, Ahlner, J., additional, Dizdar, N., additional, and Larson, G., additional
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- 2003
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26. Treatment of acute cluster headache with sumatriptan
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Ekbom, K., Waldenlind, E., Richard, Levi, Andersson, B., Boivie, J., Dizdar, N., Bousser, M.G., Tehindrazanirivelo, A., Lutz, G., Hannerz, J., Hardebo, J.E., Henry, P., Rosazza, M., Krabbe, A., Kinnman, J., Persson, L.I., Prusinski, A., Durko, A., Kozubski, W., Rozniecki, M.D., Wysocka-Bakowska, M.M., Cole, J.A., Patel, P., Pilgrim, AJ., Winter, O'B., Donoghue, S., Ekbom, K., Waldenlind, E., Richard, Levi, Andersson, B., Boivie, J., Dizdar, N., Bousser, M.G., Tehindrazanirivelo, A., Lutz, G., Hannerz, J., Hardebo, J.E., Henry, P., Rosazza, M., Krabbe, A., Kinnman, J., Persson, L.I., Prusinski, A., Durko, A., Kozubski, W., Rozniecki, M.D., Wysocka-Bakowska, M.M., Cole, J.A., Patel, P., Pilgrim, AJ., Winter, O'B., and Donoghue, S.
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- 1991
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27. Microdialysis of 5-S-cysteinyldopa from interstitial fluid in cutaneous human melanoma transplanted to athymic mice
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Blomquist, L., Dizdar, N., Karlsson, M., Kågedal, Bertil, Ossowicki, H., Pettersson, A., Smeds, Staffan, Blomquist, L., Dizdar, N., Karlsson, M., Kågedal, Bertil, Ossowicki, H., Pettersson, A., and Smeds, Staffan
- Abstract
Microdialysis was investigated as a tool for the determination of the extracellular concentration of the pigment metabolite 5-S-cysteinyldopa in human melanoma transplanted to athymic mice. Histology of the tumour with the microdialysis probes in situ showed no tissue damage. With probes equipped with polycarbonate membranes (20 kD) extraction (relative recovery) was approximately 50% at pH 4.0 and flow rates of 1 microliter/min, but at pH 7.0 recoveries were markedly lower, particularly from serum. In a first series of human melanomas transplanted to athymic mice low concentrations of 5-S-cysteinyldopa were detected in only two out of ten dialysates and were not detected in the other eight. Utilizing devices constructed for comparison of membrane characteristics in vitro we found about 4-fold higher recoveries with cuprophane and polyamide membranes than with polycarbonate membranes. Therefore newly constructed microdialysis probes (CMA/11) with cuprophane membranes were tested in vitro and gave recoveries of 38-48% from Ringer-Acetate solutions and 22-31% from serum, and the pH effects were low. When these probes were utilized in a second series of melanomas transplanted to athymic mice, 5-S-cysteinyldopa could easily be quantified in 10/10 experiments. A steady-state level of the dialysate 5-S-cysteinyldopa concentration was reached after 45 min.
- Published
- 1991
28. Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants
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Dizdar, N, primary, Kullman, A, additional, K??gedal, B, additional, and Arstrand, K, additional
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- 1997
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29. Microdialysis of 5-S-cysteinyldopa from interstitial fluid in cutaneous human melanoma transplanted to athymic mice
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Blomquist, L., primary, Dizdar, N., additional, Karlsson, M., additional, Kågedal, B., additional, Ossowicki, H., additional, Pettersson, A., additional, and Smeds, S., additional
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- 1991
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30. A high-sensitivity fluorometric high-performance liquid chromatographic method for determination of glutathione and other thiols in cultured melanoma cells, microdialysis samples from melanoma tissue, and blood plasma
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Dizdar, N., primary, Kågedal, B., additional, Smeds, S., additional, and Årstrand, K., additional
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- 1991
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31. Duodenal nevodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease.
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Nyholm D, Remahl AIM, Dizdar N, Constantinescu R, Holmberg B, Jansson R, Aquilonius S, and Askmark H
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- 2005
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32. Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice.
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Dizdar, Nil, Kullman, Anita, Kågedal, Bertil, Dizdar, N, Kullman, A, and Kågedal, B
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GLUTATHIONE ,MELANOMA ,OLIGOPEPTIDES ,NEUROENDOCRINE tumors ,TUMORS ,CHEMICALS - Abstract
Purpose: Glutathione is an important cellular compound which affects detoxification of electrophiles and may have direct or indirect effects on pigment formation. It is therefore of importance to study interstitial concentrations in melanoma tissue while decreasing its formation with an enzyme inhibitor and increasing its amount with cysteine deliverers.Method: Glutathione formation was inhibited by intraperitoneal (i.p.) injection of BSO. N-Acetylcysteine (NAC) and l-2-oxothiazolidine-4-carboxylate (OTC) were then given i.p. to subgroups of the animals. Intratumoral microdialysis was performed during BSO treatment, during BSO treatment combined with NAC or OTC and after discontinuation of BSO but ongoing NAC or OTC treatment.Results: Glutathione formation was inhibited during BSO treatment. The dialysate concentrations of both glutathione and cysteine decreased during concomitant treatment with BSO and NAC or OTC. Recovery of the amounts of the two compounds was seen in both groups after discontinuation of BSO treatment. In the NAC group we also observed an acute increase in dialysate concentrations of cysteine after NAC injection. The 5-S-cysteinyldopa concentrations were unaffected by variations in glutathione and cysteine concentrations.Conclusions: 5-S-Cysteinyldopa in melanoma is not formed from glutathione in vivo to any appreciable extent. The intracellular amount of cysteine is probably not a limiting factor for cysteinyldopa formation. It seems that both NAC and OTC can be used as cysteine deliverers to melanoma cells in vivo to produce recovery of glutathione levels after synthesis inhibition by BSO treatment. [ABSTRACT FROM AUTHOR]- Published
- 2000
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33. Treatment of Parkinson's disease with NADH.
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Dizdar, N., Kågedal, B., and Lindvall, B.
- Published
- 1994
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34. Intratracheal Ectopic Thyroid Tissue Mimicking a Subglottic Mass in a Patient With Thyroid Follicular Carcinoma on SPECT/CT.
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Aydinbelge-Dizdar N, Cinar A, Ozmen O, and Senlik SD
- Abstract
Abstract: Intratracheal ectopic thyroid tissue is an extremely rare condition with limited cases reported in the literature. It can be asymptomatic or present with symptoms such as dysphagia, bleeding, dysphonia, dyspnea, and a sensation of a foreign body in the throat, depending on its localization. Due to its various clinical presentations, it poses a diagnostic dilemma. Herein, we aimed to present the contribution of thyroid scintigraphy and SPECT/CT to the diagnosis and management of a case with follicular carcinoma in the orthotopic thyroid gland as well as an ectopic intratracheal thyroid causing cough and airway obstruction mimicking a subglottic mass., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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35. Motor Efficacy of Subcutaneous DIZ102, Intravenous DIZ101 or Intestinal Levodopa/Carbidopa Infusion.
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Bergquist F, Ehrnebo M, Nyholm D, Johansson A, Lundin F, Odin P, Svenningsson P, Dizdar N, and Eriksson E
- Abstract
Background: It has been suggested that carbidopa at high blood concentrations may counter the therapeutic effect of levodopa in Parkinson's disease by entering the brain and blocking central levodopa conversion to dopamine. We previously demonstrated equivalent plasma levodopa concentration in patients with Parkinson's disease during 16 h of (1) intravenous carbidopa/levodopa (DIZ101) infusion, (2) subcutaneous carbidopa/levodopa (DIZ102) infusion or (3) intestinal carbidopa/levodopa gel infusion. Plasma levels of carbidopa were however approximately four times higher with DIZ101 and DIZ102 than with LCIG, and higher than those usually observed with oral levodopa/carbidopa., Objectives: To investigate if high carbidopa blood concentrations obtained with parenteral levodopa/carbidopa (ratio 8:1) counter the effect of levodopa on motor symptoms., Methods: Eighteen patients with advanced Parkinson's disease were administered DIZ101, DIZ102, and intestinal levodopa/carbidopa gel for 16 h on different days in randomized order. Video recordings of a subset of the motor examination in the Unified Parkinson's Disease Rating Scale (UPDRS) were evaluated by raters blinded for treatment and time. Motor function was also measured using a wrist-worn device monitoring bradykinesia, dyskinesia, and tremor (Parkinson KinetiGraph)., Results: There was no tendency for poorer levodopa effect with DIZ101 or DIZ102 as compared to LCIG., Conclusion: Although DIZ101 or DIZ102 causes approximately four times higher plasma carbidopa levels than LCIG, patients responded equally well to all treatments. The results do not indicate that high plasma carbidopa levels hamper the motor efficacy of levodopa., (© 2024 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
- Published
- 2024
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36. Awake craniotomy in epilepsy surgery includes previously inoperable patients with preserved efficiency and safety.
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Vigren P, Eriksson M, Gauffin H, Duffau H, Milos P, Eek T, and Dizdar N
- Abstract
Introduction: Whilst awake craniotomy has been widely used historically in epilepsy surgery, the safety and efficacy of this approach in epilepsy surgery has been sparsely investigated in controlled studies. The objective of this study is to investigate the safety and efficacy of awake resection in epilepsy surgery and focuses on the possibility to widen surgical indications with awake surgery. Methods: Fifteen patients operated with awake epilepsy surgery were compared to 30 matched controls undergoing conventional/asleep epilepsy surgery. The groups were compared with regard to neurological complications, seizure control and location of resection. Results: Regarding seizure control, 86% of patients in the awake group reached Engel grade 1-2 compared to 73% in the control group, operated with conventional/asleep surgery, not a statistically significant difference. Neither was there a statistical significant difference regarding postoperative neurological complications. However, there was a significant difference in location of the resection when comparing the two groups. Of the 15 patients operated with awake intraoperative mapping, four had previously been considered as non-operable by epilepsy surgery centres, due to vicinity to eloquent brain regions and predicted risk of post-operative neurological deficits. Discussion: The results show that awake epilepsy surgery yields similar level of seizure control when compared to conventional asleep surgery, with maintained safety in regard to neurological complications. Furthermore, the results indicate that awake craniotomy in epilepsy surgery is feasible and possible in patients otherwise regarded as inoperable with epileptigenic zone in proximity to eloquent brain structures.
- Published
- 2023
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37. Nasal mucociliary clearance after extremely low frequency by scintigraphic and histopathologic evaluation.
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Aydinbelge-Dizdar N, Akbulut A, Koca G, Yumusak N, Canseven Kursun AG, Billur D, and Korkmaz M
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- Rats, Animals, Nasal Mucosa, Inflammation diagnostic imaging, Goblet Cells, Mucociliary Clearance, Hyperemia
- Abstract
Objective: To investigate the effect of exposure to extremely low-frequency magnetic fields (ELF-MFs) on nasal mucociliary clearance (MCC) by rhinosintigrapic and histopathological evaluation., Materials and Methods: The rats were separated into three groups according to ELF-MFs intensity and control group. The exposure groups were standardized for the ELF-MFs of 1, 1.5, and 2 mT emitted by 3 Helmholtz coils for 4 h/day for 30 days. Rhinoscintigraphy was performed to measure nasal MCC. The nasal tissues were examined for edema, inflammation, hyperemia, necrosis, ciliary loss, goblet cell density, and fibroblast proliferation. The data were evaluated statistically (p < 0.05)., Results: Nasal mucociliary clearance rates (NMCR) were calculated as 33.13 ± 5.91% in control, 27.78 ± 4.7% in 1 mT, 22.67 ± 5.43% in 1.5 mT, and 18.11 ± 6.33% in 2 mT. NMCR were decreased with increasing ELF-MFs, in 1.5 and 2 mT groups (p < 0.05) compared to control. Nasal mucociliary transport rate (NMTR) values were found to be 2.17 ± 0.33 mm/min in control, 1.82 ± 0.32 mm/min in 1 mT, 1.46 ± 0.34 mm/min in 1.5 mT and 1.24 ± 0.29 mm/min in 2 mT. NMTR was decreased in the groups exposed to 1.5 and 2 mT (p < 0.05) compared to control. The edema, hyperemia, inflammation, ciliary loss, and goblet cell density were statistically significant differences between control and groups exposed to 1.5 and 2 mT (p < 0.05)., Conclusion: Our rat model has shown nasal mucosa damage and decreased NMCR and NMTR by rhinoscintigraphy as ELF-MFs intensity increases. It may be detrimental to nasal mucosa mucociliary function depending on the ELF-MFs intensity., Level of Evidence: N/A Laryngoscope, 133:2081-2089, 2023., (© 2022 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2023
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38. Pharmacokinetics of Intravenously (DIZ101), Subcutaneously (DIZ102), and Intestinally (LCIG) Infused Levodopa in Advanced Parkinson Disease.
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Bergquist F, Ehrnebo M, Nyholm D, Johansson A, Lundin F, Odin P, Svenningsson P, Hansson F, Bring L, Eriksson E, and Dizdar N
- Subjects
- Humans, Carbidopa therapeutic use, Antiparkinson Agents adverse effects, Infusions, Parenteral, Gels therapeutic use, Drug Combinations, Levodopa adverse effects, Parkinson Disease drug therapy
- Abstract
Background and Objectives: Intestinal levodopa/carbidopa gel infusion (LCIG) is superior to oral treatment in advanced Parkinson disease. The primary objective of this trial was to investigate whether continuous subcutaneous or intravenous infusion with a continuously buffered acidic levodopa/carbidopa solution yields steady-state plasma concentrations of levodopa that are equivalent in magnitude, and noninferior in variability, to those obtained with LCIG in patients with advanced Parkinson disease., Methods: A concentrated acidic levodopa/carbidopa (8:1) solution buffered continuously and administered intravenously (DIZ101) or subcutaneously (DIZ102) was compared with an approved LCIG in a randomized, 3-period crossover, open-label, multicenter trial. Formulations were infused for 16 hours to patients with Parkinson disease who were using LCIG as their regular treatment. Patients were recruited from several university neurology clinics but came to the same phase I unit for treatment. Pharmacokinetic variables and safety including dermal tolerance are reported. The primary outcomes were bioequivalence and noninferior variability of DIZ101 and DIZ102 vs LCIG with respect to levodopa plasma concentrations., Results: With dosing adjusted to estimated bioavailability, DIZ101 and DIZ102 produced levodopa plasma levels within standard bioequivalence limits compared with LCIG in the 18 participants who received all treatments. Although the levodopa bioavailability for DIZ102 was complete, it was 80% for LCIG. Therapeutic concentrations of levodopa were reached as quickly with subcutaneous administration of DIZ102 as with LCIG and remained stable throughout the infusions. Owing to poor uptake of LCIG, carbidopa levels in plasma were higher with DIZ101 and DIZ102 than with the former. All individuals receiving any of the treatments (n = 20) were included in the evaluation of safety and tolerability. Reactions at the infusion sites were mild and transient., Discussion: It is feasible to rapidly achieve high and stable levodopa concentrations by means of continuous buffering of a subcutaneously administered acidic levodopa/carbidopa-containing solution., Trial Registration Information: ClinicalTrials.gov identifier: NCT03419806. Registration first posted on February 5, 2018, first patient enrolled on February 16, 2018., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)
- Published
- 2022
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39. Early diagnosis of autism in the community is associated with marked improvement in social symptoms within 1-2 years.
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Gabbay-Dizdar N, Ilan M, Meiri G, Faroy M, Michaelovski A, Flusser H, Menashe I, Koller J, Zachor DA, and Dinstein I
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- Autistic Disorder complications, Child, Child, Preschool, Early Diagnosis, Humans, Infant, Longitudinal Studies, Mass Screening methods, Autism Spectrum Disorder complications, Autism Spectrum Disorder diagnosis
- Abstract
Lay Abstract: It is widely believed that early diagnosis and treatment of autism spectrum disorder is essential for better outcome. This is demonstrated by the American Academy of Pediatrics recommendation to screen all 1.5-2.5-year-old toddlers for autism spectrum disorder. However, multiple longitudinal studies of children diagnosed with autism spectrum disorder at 1.5-6 years of age and treated in community settings have not reported any associations between earlier diagnosis and improved outcome in core autism spectrum disorder symptoms. In this study, we measured changes in core autism spectrum disorder symptoms over a 1-2-year period in 131 children diagnosed with autism spectrum disorder at 1.2-5 years of age, and treated in the community. The results revealed that children who were diagnosed before 2.5 years of age were three times more likely to exhibit considerable improvements in social autism spectrum disorder symptoms in comparison to children diagnosed at later ages. These results highlight the importance of early diagnosis and treatment of autism spectrum disorder even in community settings with heterogeneous services. In addition, these results motivate further prioritization of universal screening for autism spectrum disorder before 2.5 years of age.
- Published
- 2022
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40. Odor Recognition Memory in Parkinson's Disease: A Systematic Review.
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Eek T, Larsson M, and Dizdar N
- Abstract
Olfactory impairment is a central non-motor symptom in Parkinson's disease (PD). Previous studies have demonstrated that olfactory dysfunction is associated with mental illness and impaired cognition. The frequently investigated olfactory functions are odor detection, discrimination, and identification. However, few studies have focused on odor recognition memory (ORM). ORM tasks involves episodic memory which therefore can facilitate the detection of dementia among patients with PD and consequently adjust their treatment. Thus, the aim of this systematic review is to summarize the existing research on ORM in PD. Databases and reference lists were used for data collection. Studies were included in the review if they met the eligibility criteria derived from the PICOS-framework. Quality evaluation of the studies was based on the STROBE-statement. Six studies with small samples were included in the analysis which demonstrated the scarce research on the subject. The studies targeting ORM were heterogenous and involved two main tasks: odor recognition and odor matching. The synthesis of the data demonstrated that PD patients performed significantly lower than controls on both tasks, especially on odor matching task. Only the odor recognition task exhibited a difference between patients with PD vs. Alzheimer's disease (AD). PD patients performed significantly better than AD patients. The findings based on the available limited data support the notion that odor recognition task can be of importance in identifying Parkinson's disease dementia (PDD). To investigate this hypothesis, future research needs to include larger samples of PD, PDD and AD patients executing the same odor recognition task., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Eek, Larsson and Dizdar.)
- Published
- 2021
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41. Apomorphine formulation may influence subcutaneous complications from continuous subcutaneous apomorphine infusion in Parkinson's disease.
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Hagell P, Höglund A, Hellqvist C, Johansson EL, Löwed B, Sjöström AC, Karlberg C, Lundgren M, Dizdar N, Johansson A, Willows T, Rådberg J, and Bergquist F
- Subjects
- Antiparkinson Agents adverse effects, Humans, Injections, Subcutaneous, Levodopa adverse effects, Prospective Studies, Apomorphine adverse effects, Parkinson Disease drug therapy
- Abstract
Continuous subcutaneous (s.c.) apomorphine infusion is an effective therapy for Parkinson's disease (PD), but a limitation is the formation of troublesome s.c. nodules. Various chemically non-identical apomorphine formulations are available. Anecdotal experiences have suggested that shifting from one of these (Apo-Go PumpFill
® ; apoGPF) to another (Apomorphine PharmSwed® ; apoPS) may influence the occurrence and severity of s.c. nodules. We, therefore, followed 15 people with advanced PD (median PD-duration, 15 years; median "off"-phase Hoehn and Yahr, IV) on apoGPF and with troublesome s.c. nodules who were switched to apoPS. Data were collected at baseline, at the time of switching, and at a median of 1, 2.5, and 7.3 months post-switch. Total nodule numbers (P < 0.001), size (P < 0.001), consistency (P < 0.001), skin changes (P = 0.058), and pain (P ≤ 0.032) improved over the observation period. PD severity and dyskinesias tended to improve and increase, respectively. Apomorphine doses were stable, but levodopa doses increased by 100 mg/day. Patient-reported apomorphine efficacy tended to increase and all participants remained on apoPS throughout the observation period; with the main patient-reported reason being improved nodules. These observations suggest that patients with s.c. nodules caused by apoGPF may benefit from switching to apoPS in terms of s.c. nodule occurrence and severity. Alternatively, observed benefits may have been due to the switch itself. As nodule formation is a limiting factor in apomorphine treatment, a controlled prospective study comparing local tolerance with different formulations is warranted.- Published
- 2020
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42. Effects of self-management education for persons with Parkinson's disease and their care partners: A qualitative observational study in clinical care.
- Author
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Hellqvist C, Berterö C, Hagell P, Dizdar N, and Sund-Levander M
- Subjects
- Aged, Aged, 80 and over, Caregivers psychology, Caregivers statistics & numerical data, Female, Health Personnel statistics & numerical data, Health Promotion methods, Humans, Interviews as Topic methods, Male, Middle Aged, Parkinson Disease psychology, Patient Education as Topic methods, Patient Education as Topic statistics & numerical data, Patients psychology, Patients statistics & numerical data, Qualitative Research, Self-Management methods, Sweden, Health Personnel education, Parkinson Disease therapy, Patient Education as Topic standards, Self-Management education
- Abstract
Persons with Parkinson's disease and their care partners want support from health care to develop the skills to handle everyday life with the long-term condition. Earlier findings indicate that participants of the self-management program Swedish National Parkinson School experience several benefits of the program. The purpose of this qualitative observational study was to explore if participants had implemented the strategies of self-monitoring included in the program and use them to communicate health care status and needs in clinical encounters. Data were collected 3 to 15 months after participation in the program and analyzed using constant comparative analysis. Three categories were evident: "Self-observation in everyday life," "Self-care activities to promote health," and "Managing emotional impact of Parkinson's Disease." Categories were linked together in a core category that highlight the use of self-management strategies described by participants during clinical encounters. Results confirmed that persons with Parkinson's disease and care partners use the techniques of self-observation in their everyday lives. Observations of effects in clinical care can be a valuable approach to evaluate the outcomes educational interventions and their benefits for individuals and health care., (© 2020 The Authors Nursing & Health Sciences Published by John Wiley & Sons Australia, Ltd.)
- Published
- 2020
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43. A Phase 2a Trial Investigating the Safety and Tolerability of the Novel Cortical Enhancer IRL752 in Parkinson's Disease Dementia.
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Svenningsson P, Odin P, Dizdar N, Johansson A, Grigoriou S, Tsitsi P, Wictorin K, Bergquist F, Nyholm D, Rinne J, Hansson F, Sonesson C, and Tedroff J
- Subjects
- Antiparkinson Agents therapeutic use, Cerebral Cortex, Double-Blind Method, Humans, Levodopa, Dementia drug therapy, Parkinson Disease drug therapy
- Abstract
Background: IRL752 is a novel small-molecule compound that acts to regioselectively enhance norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex., Objective: The primary objective of the trial was to investigate the safety and tolerability of IRL752 in patients with Parkinson's disease and dementia., Methods: Patients with Parkinson's disease and dementia were randomized to IRL752 or placebo treatment (3:1 ratio) for 28 days. The study drug was given as an adjunct treatment to the patients' regular stable antiparkinsonian medication. Dosing was individually titrated for 14 days after which the dose was kept stable for an additional 14 days., Results: A total of 32 patients were randomized to treatment, and 29 patients completed the 4-week treatment. Adverse events were generally mild and transient and were mostly reported during the dose titration phase. There were 2 serious adverse events, and none of them were related to the experimental treatment. The average dose achieved in the stable dose phase was 600 mg daily, yielding a 2-hour postdose plasma concentration of about 4 μM on day 28. Exploratory assessment of secondary outcomes indicated efficacy for symptoms and signs known to be poorly responsive to levodopa., Conclusions: IRL752 appears to be safe and well tolerated for a 4-week treatment in patients with Parkinson's disease and dementia. © 2020 International Parkinson and Movement Disorder Society., (© 2020 International Parkinson and Movement Disorder Society.)
- Published
- 2020
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44. Self-Management Education for Persons with Parkinson's Disease and Their Care Partners: A Quasi-Experimental Case-Control Study in Clinical Practice.
- Author
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Hellqvist C, Berterö C, Dizdar N, Sund-Levander M, and Hagell P
- Abstract
Background: Parkinson's disease is a neurodegenerative condition with both physical and mental consequences that affect many aspects of everyday life. Persons with Parkinson's disease and their care partners want guidance from healthcare services in order to develop skills to adjust to life with a long-term condition. The Swedish National Parkinson School is a dyadic self-management programme to support both persons with Parkinson's disease and care partners., Objective: To assess the outcomes of the Swedish National Parkinson School as reported by participants., Design: A quasi-experimental case-control study in clinical care using self-reported questionnaires. Participants. Swedish National Parkinson School was offered by health care professionals working in clinical care. Participants in the programme were also asked to participate in the study. A matched control group was recruited for a comparison of findings. In total, 92 persons with Parkinson's disease and 55 care partners were included. Settings . Five Swedish geriatric and neurologic outpatient clinics., Method: Data were collected during 2015-2017, before and after participation in the National Parkinson School or before and after seven weeks of standard care. Outcomes were assessed using generic and Parkinson's specific questionnaires. Descriptive statistics were used to describe baseline characteristics. Mann-Whitney U and Chi
2 tests were used to test for between-group differences and within-group differences were tested by the Wilcoxon signed-ranks test., Results: Improvements regarding health status, constructive attitudes and approaches, and skill and technique acquisition were found after the intervention among persons with Parkinson's disease. No changes were found among care partners., Conclusion: The findings indicate that the Swedish National Parkinson School may improve health status and self-management among persons with Parkinson's disease, but further studies are needed to better understand the effects of the programme., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper., (Copyright © 2020 Carina Hellqvist et al.)- Published
- 2020
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45. Group-based music intervention in Parkinson's disease - findings from a mixed-methods study.
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Pohl P, Wressle E, Lundin F, Enthoven P, and Dizdar N
- Subjects
- Accidental Falls, Aged, Attention, Female, Gait, Humans, Male, Middle Aged, Parkinson Disease complications, Parkinson Disease physiopathology, Physical Therapy Modalities, Postural Balance, Quality of Life, Single-Blind Method, Music Therapy, Neurological Rehabilitation, Parkinson Disease rehabilitation
- Abstract
Objective: To evaluate a group-based music intervention in patients with Parkinson's disease., Design: Parallel group randomized controlled trial with qualitative triangulation., Setting: Neurorehabilitation in primary care., Subjects: Forty-six patients with Parkinson's disease were randomized into intervention group ( n = 26), which received training with the music-based intervention, and control group ( n = 20) without training., Interventions: The intervention was delivered twice weekly for 12 weeks., Main Measures: Primary outcome was Timed-Up-and-Go subtracting serial 7's (dual-task ability). Secondary outcomes were cognition, balance, concerns about falling, freezing of gait, and quality of life. All outcomes were evaluated at baseline, post-intervention, and three months post-intervention. Focus groups and individual interviews were conducted with the intervention group and with the delivering physiotherapists., Results: No between-group differences were observed for dual-task ability. Between-group differences were observed for Falls Efficacy Scale (mean difference (MD) = 6.5 points; 95% confidence interval (CI) = 3.0 to 10.0, P = 0.001) and for Parkinson Disease Questionnaire-39 items (MD = 8.3; 95% CI = 2.7 to 13.8, P = 0.005) when compared to the control group post-intervention, but these were not maintained at three months post-intervention. Three themes were derived from the interviews: Expectations versus Results, Perspectives on Treatment Contents , and Key Factors for Success ., Conclusion: Patient-reported outcomes and interviews suggest that the group-based music intervention adds value to mood, alertness, and quality of life in patients with Parkinson's disease. The study does not support the efficacy in producing immediate or lasting gains in dual-tasking, cognition, balance, or freezing of gait.
- Published
- 2020
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46. [Parkinson's disease - heterogeneous and complex in its clinical presentation].
- Author
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Bergquist F, Johansson A, Dizdar N, Widner H, Nyholm D, Odin P, and Svenningsson P
- Subjects
- Humans, Neurodegenerative Diseases, Parkinson Disease complications, Parkinson Disease diagnosis
- Abstract
Parkinson's disease is the second most common neurodegenerative disease. Lewy bodies with alpha-synuclein as the major component and loss of dopaminergic nerve cells in substantia nigra are neuropathological features. The diagnosis of Parkinson's disease is based on the occurrence of bradykinesia, rigidity and resting tremor. The disease is also associated with several non-motor symptoms. The therapy is mainly based on pharmacological treatment to increase dopamine signaling and neurosurgical deep brain stimulation. The symptoms and signs of the progressive disease change over time, requiring treatment adjustments. Patients should be followed by a physician, nurse and a multidisciplinary team with expertise in Parkinson's disease.
- Published
- 2020
47. A study of neural activity and functional connectivity within the olfactory brain network in Parkinson's disease.
- Author
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Georgiopoulos C, Witt ST, Haller S, Dizdar N, Zachrisson H, Engström M, and Larsson EM
- Subjects
- Aged, Cerebral Cortex diagnostic imaging, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net diagnostic imaging, Parkinson Disease diagnostic imaging, Cerebral Cortex physiopathology, Connectome, Nerve Net physiopathology, Olfactory Perception physiology, Parkinson Disease physiopathology
- Abstract
Olfactory dysfunction is an early manifestation of Parkinson's disease (PD). The present study aimed to illustrate potential differences between PD patients and healthy controls in terms of neural activity and functional connectivity within the olfactory brain network. Twenty PD patients and twenty healthy controls were examined with olfactory fMRI and resting-state fMRI. Data analysis of olfactory fMRI included data-driven tensorial independent component (ICA) and task-driven general linear model (GLM) analyses. Data analysis of resting-state fMRI included probabilistic ICA based on temporal concatenation and functional connectivity analysis within the olfactory network. ICA of olfactory fMRI identified an olfactory network consisting of the posterior piriform cortex, insula, right orbitofrontal cortex and thalamus. Recruitment of this network was less significant for PD patients. GLM analysis revealed significantly lower activity in the insula bilaterally and the right orbitofrontal cortex in PD compared to healthy controls but no significant differences in the olfactory cortex itself. Analysis of resting-state fMRI did not reveal any differences in the functional connectivity within the olfactory, default mode, salience or central executive networks between the two groups. In conclusion, olfactory dysfunction in PD is associated with less significant recruitment of the olfactory brain network. ICA could demonstrate differences in both the olfactory cortex and its main projections, compared to GLM that revealed differences only on the latter. Resting-state fMRI did not reveal any significant differences in functional connectivity within the olfactory, default mode, salience and central executive networks in this cohort., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
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48. Improving self-management for persons with Parkinson's disease through education focusing on management of daily life: Patients' and relatives' experience of the Swedish National Parkinson School.
- Author
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Hellqvist C, Dizdar N, Hagell P, Berterö C, and Sund-Levander M
- Subjects
- Adaptation, Psychological, Adult, Aged, Female, Humans, Male, Middle Aged, Self-Management methods, Sweden, Activities of Daily Living psychology, Parkinson Disease psychology, Parkinson Disease rehabilitation, Quality of Life psychology, Self Care methods, Self-Management education
- Abstract
Aims and Objective: To identify and describe experiences valuable for managing daily life after participation in the NPS self-management intervention. The second part was to explore the applicability of the Self- and family management framework by Grey and colleagues for persons with Parkinson's Disease and their relatives., Background: The impact of PD is evident on the lives of both patients and relatives. The National Parkinson School (NPS) is a Swedish self-management programme designed for patients and relatives, aiming at teaching strategies helpful for the ability of self-management, in order to promote life satisfaction., Design: Qualitative explorative with inductive and deductive analysis., Methods: Five group discussions with NPS participants were audio-recorded. Verbatim transcriptions were analysed inductively with thematic analysis according to Braun and Clarke, and the findings were then applied deductively to the existing model for patients with chronic disease., Results: Through the first step of inductive analysis, three themes capturing the meaning, value and experience of being a participant at the NPS were identified: exchanging experiences and feeling support, adjustment and acceptance of PD for managing daily life and promoting life satisfaction. The deductive analysis applied the inductive findings to the Self- and family management framework of chronically ill to explore the fit to persons with PD and relatives attending the NPS programme., Conclusions: The NPS programme is a promising approach for helping persons with PD and their relatives to achieve better self-management of disease and improved life satisfaction. Further evaluations of programme outcomes in clinical practice are warranted., Relevance of Clinical Practice: Self-management programmes like the NPS is a promising approach in facilitating a positive mindset and outlook on life and gain knowledge to understand, adapt and handle chronic disease, such as PD, better., (© 2018 John Wiley & Sons Ltd.)
- Published
- 2018
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49. Olfactory fMRI: Implications of Stimulation Length and Repetition Time.
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Georgiopoulos C, Witt ST, Haller S, Dizdar N, Zachrisson H, Engström M, and Larsson EM
- Subjects
- Adult, Brain Mapping, Humans, Male, Odorants, Olfactory Pathways pathology, Time Factors, Magnetic Resonance Imaging, Olfactory Pathways physiology, Smell physiology
- Abstract
Studying olfaction with functional magnetic resonance imaging (fMRI) poses various methodological challenges. This study aimed to investigate the effects of stimulation length and repetition time (TR) on the activation pattern of 4 olfactory brain regions: the anterior and the posterior piriform cortex, the orbitofrontal cortex, and the insula. Twenty-two healthy participants with normal olfaction were examined with fMRI, with 2 stimulation lengths (6 s and 15 s) and 2 TRs (0.901 s and 1.34 s). Data were analyzed using General Linear Model (GLM), Tensorial Independent Component Analysis (TICA), and by plotting the event-related time course of brain activation in the 4 olfactory regions of interest. The statistical analysis of the time courses revealed that short TR was associated with more pronounced signal increase and short stimulation was associated with shorter time to peak signal. Additionally, both long stimulation and short TR were associated with oscillatory time courses, whereas both short stimulation and short TR resulted in more typical time courses. GLM analysis showed that the combination of short stimulation and short TR could result in visually larger activation within these olfactory areas. TICA validated that the tested paradigm was spatially and temporally associated with a functionally connected network that included all 4 olfactory regions. In conclusion, the combination of short stimulation and short TR is associated with higher signal increase and shorter time to peak, making it more amenable to standard GLM-type analyses than long stimulation and long TR, and it should, thus, be preferable for olfactory fMRI.
- Published
- 2018
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50. S100B polymorphisms are associated with age of onset of Parkinson's disease.
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Fardell C, Zettergren A, Ran C, Carmine Belin A, Ekman A, Sydow O, Bäckman L, Holmberg B, Dizdar N, Söderkvist P, and Nissbrandt H
- Subjects
- 3' Untranslated Regions genetics, Aged, Alleles, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotyping Techniques, Humans, Linear Models, Male, Parkinson Disease diagnosis, Proportional Hazards Models, Sweden, Age of Onset, Parkinson Disease genetics, Polymorphism, Single Nucleotide, S100 Calcium Binding Protein beta Subunit genetics
- Abstract
Background: In this study we investigated the association between SNPs in the S100B gene and Parkinson's disease (PD) in two independent Swedish cohorts. The SNP rs9722 has previously been shown to be associated with higher S100B concentrations in serum and frontal cortex in humans. S100B is widely expressed in the central nervous system and has many functions such as regulating calcium homeostasis, inflammatory processes, cytoskeleton assembly/disassembly, protein phosphorylation and degradation, and cell proliferation and differentiation. Several of these functions have been suggested to be of importance for the pathophysiology of PD., Methods: The SNPs rs9722, rs2239574, rs881827, rs9984765, and rs1051169 of the S100B gene were genotyped using the KASPar® PCR SNP genotyping system in a case-control study of two populations (431 PD patients and 465 controls, 195 PD patients and 378 controls, respectively). The association between the genotype and allelic distributions and PD risk was evaluated using Chi-Square and Cox proportional hazards test, as well as logistic regression. Linear regression and Cox proportional hazards tests were applied to assess the effect of the rs9722 genotypes on age of disease onset., Results: The S100B SNPs tested were not associated with the risk of PD. However, in both cohorts, the T allele of rs9722 was significantly more common in early onset PD patients compared to late onset PD patients. The SNP rs9722 was significantly related to age of onset, and each T allele lowered disease onset with 4.9 years. In addition, allelic variants of rs881827, rs9984765, and rs1051169, were significantly more common in early-onset PD compared to late-onset PD in the pooled population., Conclusions: rs9722, a functional SNP in the 3'-UTR of the S100B gene, was strongly associated with age of onset of PD.
- Published
- 2018
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