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457 results on '"Disanza A"'

1. TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression

Author

Garcia-Montojo, Marta, Fathi, Saeed, Rastegar, Cyrus, Simula, Elena Rita, Doucet-O’Hare, Tara, Cheng, Y. H. Hank, Abrams, Rachel P. M., Pasternack, Nicholas, Malik, Nasir, Bachani, Muzna, Disanza, Brianna, Maric, Dragan, Lee, Myoung-Hwa, Wang, Herui, Santamaria, Ulisses, Li, Wenxue, Sampson, Kevon, Lorenzo, Juan Ramiro, Sanchez, Ignacio E., Mezghrani, Alexandre, Li, Yan, Sechi, Leonardo Antonio, Pineda, Sebastian, Heiman, Myriam, Kellis, Manolis, Steiner, Joseph, and Nath, Avindra

Published
2024
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4. A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

Author

Xarxa Quiroga, Nikhil Walani, Andrea Disanza, Albert Chavero, Alexandra Mittens, Francesc Tebar, Xavier Trepat, Robert G Parton, María Isabel Geli, Giorgio Scita, Marino Arroyo, Anabel-Lise Le Roux, and Pere Roca-Cusachs

Subjects
mechanobiology, bar proteins, membrane biophysics, Medicine, Science, Biology (General), QH301-705.5
Abstract

As cells migrate and experience forces from their surroundings, they constantly undergo mechanical deformations which reshape their plasma membrane (PM). To maintain homeostasis, cells need to detect and restore such changes, not only in terms of overall PM area and tension as previously described, but also in terms of local, nanoscale topography. Here, we describe a novel phenomenon, by which cells sense and restore mechanically induced PM nanoscale deformations. We show that cell stretch and subsequent compression reshape the PM in a way that generates local membrane evaginations in the 100 nm scale. These evaginations are recognized by I-BAR proteins, which triggers a burst of actin polymerization mediated by Rac1 and Arp2/3. The actin polymerization burst subsequently re-flattens the evagination, completing the mechanochemical feedback loop. Our results demonstrate a new mechanosensing mechanism for PM shape homeostasis, with potential applicability in different physiological scenarios.

Published
2023
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8. Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis

Author

Moreno-Layseca, Paulina, Jäntti, Niklas Z., Godbole, Rashmi, Sommer, Christian, Jacquemet, Guillaume, Al-Akhrass, Hussein, Conway, James R. W., Kronqvist, Pauliina, Kallionpää, Roosa E., Oliveira-Ferrer, Leticia, Cervero, Pasquale, Linder, Stefan, Aepfelbacher, Martin, Zauber, Henrik, Rae, James, Parton, Robert G., Disanza, Andrea, Scita, Giorgio, Mayor, Satyajit, Selbach, Matthias, Veltel, Stefan, and Ivaska, Johanna

Published
2021
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9. SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

Author

Tara T. Doucet-O’Hare, Brianna L. DiSanza, Catherine DeMarino, Abigail L. Atkinson, Jared S. Rosenblum, Lisa J. Henderson, Kory R. Johnson, Jeffrey Kowalak, Marta Garcia-Montojo, Sariah J. Allen, Brent A. Orr, Mariarita Santi, Tongguang Wang, Saeed Fathi, Myoung Hwa Lee, Kevon Sampson, Wenxue Li, Zhengping Zhuang, and Avindra Nath

Subjects
Medicine, Science
Abstract

Abstract Atypical Teratoid Rhabdoid Tumor (AT/RT) is a rare pediatric central nervous system cancer often characterized by deletion or mutation of SMARCB1, a tumor suppressor gene. In this study, we found that SMARCB1 regulates Human Endogenous Retrovirus K (HERV-K, subtype HML-2) expression. HML-2 is a repetitive element scattered throughout the human genome, encoding several intact viral proteins that have been associated with stem cell maintenance and tumorigenesis. We found HML-2 env expression in both the intracellular and extracellular compartments in all AT/RT cell lines (n = 4) and in 95% of AT/RT patient tissues (n = 37) evaluated. SMARCB1 knock-down in neural stem cells (NSCs) led to an upregulation of HML-2 transcription. We found that SMARCB1 binds adjacent to the HML-2 promoter, repressing its transcription via chromatin immunoprecipitation; restoration of SMARCB1 expression in AT/RT cell lines significantly downregulated HML-2 expression. Further, targeted downregulation of HML-2 transcription via CRISPR-dCas9 coupled with suppressor proteins led to cellular dispersion, decreased proliferation, and cell death in vitro. HML-2 knock-down with shRNA, siRNA, and CRISPR-dCas9 significantly decreased Ras expression as measured by qRT-PCR, suggesting that HML-2 modulates MAPK/ERK signaling in AT/RT cells. Overexpression of NRAS was sufficient to restore cellular proliferation, and MYC, a transcription factor downstream of NRAS, was bound to the HERV-K LTR significantly more in the absence of SMARCB1 expression in AT/RT cells. We show a mechanism by which these undifferentiated tumors remain pluripotent, and we demonstrate that their formation is aided by aberrant HML-2 activation, which is dependent on SMARCB1 and its interaction with MYC.

Published
2021
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11. IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

Author

Sara Bisi, Stefano Marchesi, Abrar Rizvi, Davide Carra, Galina V. Beznoussenko, Ines Ferrara, Gianluca Deflorian, Alexander Mironov, Giovanni Bertalot, Federica Pisati, Amanda Oldani, Angela Cattaneo, Ghazaleh Saberamoli, Salvatore Pece, Giuseppe Viale, Angela Bachi, Claudio Tripodo, Giorgio Scita, and Andrea Disanza

Subjects
Science
Abstract

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.

Published
2020
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12. A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

Author

Irene Schiano Lomoriello, Giovanni Giangreco, Claudia Iavarone, Chiara Tordonato, Giusi Caldieri, Gaetana Serio, Stefano Confalonieri, Stefano Freddi, Fabrizio Bianchi, Stefania Pirroni, Giovanni Bertalot, Giuseppe Viale, Davide Disalvatore, Daniela Tosoni, Maria Grazia Malabarba, Andrea Disanza, Giorgio Scita, Salvatore Pece, Brian K. Pilcher, Manuela Vecchi, Sara Sigismund, and Pier Paolo Di Fiore

Subjects
Science
Abstract

It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state and a TGFβ-dependent regulatory loop that promotes cellular plasticity and invasive behaviour.

Published
2020
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14. Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis

Author

Moreno-Layseca, Paulina, Jäntti, Niklas Z., Godbole, Rashmi, Sommer, Christian, Jacquemet, Guillaume, Al-Akhrass, Hussein, Conway, James R. W., Kronqvist, Pauliina, Kallionpää, Roosa E., Oliveira-Ferrer, Leticia, Cervero, Pasquale, Linder, Stefan, Aepfelbacher, Martin, Zauber, Henrik, Rae, James, Parton, Robert G., Disanza, Andrea, Scita, Giorgio, Mayor, Satyajit, Selbach, Matthias, Veltel, Stefan, and Ivaska, Johanna

Published
2022
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15. Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis

Author

Mugdha Sathe, Gayatri Muthukrishnan, James Rae, Andrea Disanza, Mukund Thattai, Giorgio Scita, Robert G. Parton, and Satyajit Mayor

Subjects
Science
Abstract

Several endocytic pathways operate simultaneously at the cell surface, including the clathrin and dynamin-independent CLIC/GEEC (CG) pathway. Here the authors show that small GTPases and BAR domain proteins regulate branched actin to make clathrin and dynamin-independent endocytic vesicles.

Published
2018
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16. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Author

Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri, and Giorgio Scita

Subjects
Science
Abstract

Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.

Published
2018
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17. A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

Author

Quiroga, Xarxa, primary, Walani, Nikhil, additional, Disanza, Andrea, additional, Chavero, Albert, additional, Mittens, Alexandra, additional, Tebar, Francesc, additional, Trepat, Xavier, additional, Parton, Robert G, additional, Geli, María Isabel, additional, Scita, Giorgio, additional, Arroyo, Marino, additional, Le Roux, Anabel-Lise, additional, and Roca-Cusachs, Pere, additional

Published
2023
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19. High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs

Author

Gracia-Diaz, Carolina, primary, Perdomo, Jonathan E., additional, Khan, Munir E., additional, Disanza, Brianna, additional, Cajka, Gregory G., additional, Lei, Sunyimeng, additional, Gagne, Alyssa, additional, Maguire, Jean Ann, additional, Roule, Thomas, additional, Shalem, Ophir, additional, Bhoj, Elizabeth J., additional, Ahrens-Nicklas, Rebecca C., additional, French, Deborah, additional, Goldberg, Ethan M., additional, Wang, Kai, additional, Glessner, Joseph, additional, and Akizu, Naiara, additional

Published
2023
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20. Author response: A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

Author

Quiroga, Xarxa, primary, Walani, Nikhil, additional, Disanza, Andrea, additional, Chavero, Albert, additional, Mittens, Alexandra, additional, Tebar, Francesc, additional, Trepat, Xavier, additional, Parton, Robert G, additional, Geli, María Isabel, additional, Scita, Giorgio, additional, Arroyo, Marino, additional, Le Roux, Anabel-Lise, additional, and Roca-Cusachs, Pere, additional

Published
2023
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23. A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, European Research Council, Generalitat de Catalunya, La Caixa, Fundació La Marató de TV3, Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España), Fondazione Italiana per la Ricerca sul Cancro, Ministero dell'Istruzione, dell'Università e della Ricerca, Quiroga, Xarxa, Walani, Nikhil, Disanza, Andrea, Chavero, Albert, Mittens, Alexandra, Tebar, Francesc, Trepat, Xavier, Parton, Robert G, Geli, María Isabel, Scita, Giorgio, Arroyo, Marino, Roux, Anabel-Lise Le, Roca-Cusachs, Pere, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, European Research Council, Generalitat de Catalunya, La Caixa, Fundació La Marató de TV3, Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España), Fondazione Italiana per la Ricerca sul Cancro, Ministero dell'Istruzione, dell'Università e della Ricerca, Quiroga, Xarxa, Walani, Nikhil, Disanza, Andrea, Chavero, Albert, Mittens, Alexandra, Tebar, Francesc, Trepat, Xavier, Parton, Robert G, Geli, María Isabel, Scita, Giorgio, Arroyo, Marino, Roux, Anabel-Lise Le, and Roca-Cusachs, Pere

Abstract

As cells migrate and experience forces from their surroundings, they constantly undergo mechanical deformations which reshape their plasma membrane (PM). To maintain homeostasis, cells need to detect and restore such changes, not only in terms of overall PM area and tension as previously described, but also in terms of local, nanoscale topography. Here, we describe a novel phenomenon, by which cells sense and restore mechanically induced PM nanoscale deformations. We show that cell stretch and subsequent compression reshape the PM in a way that generates local membrane evaginations in the 100 nm scale. These evaginations are recognized by I-BAR proteins, which triggers a burst of actin polymerization mediated by Rac1 and Arp2/3. The actin polymerization burst subsequently re-flattens the evagination, completing the mechanochemical feedback loop. Our results demonstrate a new mechanosensing mechanism for PM shape homeostasis, with potential applicability in different physiological scenarios.

Published
2023

28. PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State

Author

Green, Brenda J., primary, Marazzini, Margherita, additional, Hershey, Ben, additional, Fardin, Amir, additional, Li, Qingsen, additional, Wang, Zongjie, additional, Giangreco, Giovanni, additional, Pisati, Federica, additional, Marchesi, Stefano, additional, Disanza, Andrea, additional, Frittoli, Emanuela, additional, Martini, Emanuele, additional, Magni, Serena, additional, Beznoussenko, Galina V., additional, Vernieri, Claudio, additional, Lobefaro, Riccardo, additional, Parazzoli, Dario, additional, Maiuri, Paolo, additional, Havas, Kristina, additional, Labib, Mahmoud, additional, Sigismund, Sara, additional, Di Fiore, Pier Paolo, additional, Gunby, Rosalind H., additional, Kelley, Shana O., additional, and Scita, Giorgio, additional

Published
2022
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34. PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State

Author

Brenda J. Green, Margherita Marazzini, Ben Hershey, Amir Fardin, Qingsen Li, Zongjie Wang, Giovanni Giangreco, Federica Pisati, Stefano Marchesi, Andrea Disanza, Emanuela Frittoli, Emanuele Martini, Serena Magni, Galina V. Beznoussenko, Claudio Vernieri, Riccardo Lobefaro, Dario Parazzoli, Paolo Maiuri, Kristina Havas, Mahmoud Labib, Sara Sigismund, Pier Paolo Di Fiore, Rosalind H. Gunby, Shana O. Kelley, Giorgio Scita, Green, Bj, Marazzini, M, Hershey, B, Fardin, A, Li, Q, Wang, Z, Giangreco, G, Pisati, F, Marchesi, S, Disanza, A, Frittoli, E, Martini, E, Magni, S, Beznoussenko, Gv, Vernieri, C, Lobefaro, R, Parazzoli, D, Maiuri, P, Havas, K, Labib, M, Sigismund, S, Fiore, Ppd, Gunby, Rh, Kelley, So, and Scita, G.

Subjects
Breast Neoplasms, Cell Separation, General Chemistry, Neoplastic Cells, Circulating, Prognosis, Biomaterials, Mice, Cell Line, Tumor, Lab-On-A-Chip Devices, Animals, Humans, Female, General Materials Science, Biotechnology
Abstract

Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and worse patient prognosis, but are rare, difficult to count, and poorly characterized biophysically. The PillarX device described here is a bimodular microfluidic device (Pillar-device and an X-magnetic device) to profile single CTCs and clusters from whole blood based on their size, deformability, and epithelial marker expression. Larger, less deformable clusters and large single cells are captured in the Pillar-device and sorted according to pillar gap sizes. Smaller, deformable clusters and single cells are subsequently captured in the X-device and separated based on epithelial marker expression using functionalized magnetic nanoparticles. Clusters of established and primary breast cancer cells with variable degrees of cohesion driven by different cell-cell adhesion protein expression are profiled in the device. Cohesive clusters exhibit a lower deformability as they travel through the pillar array, relative to less cohesive clusters, and have greater collective invasive behavior. The ability of the PillarX device to capture clusters is validated in mouse models and patients of metastatic breast cancer. Thus, this device effectively enumerates and profiles CTC clusters based on their unique geometrical, physical, and biochemical properties, and could form the basis of a novel prognostic clinical tool.

Published
2022

36. A Stepped Care Model of Patient Navigation to Enhance Engagement with Perinatal Mental Health Care

Author

Lisa A. Chiarello, Bobbie Posmontier, Alexa Bonacquisti, Christina Bricca DiSanza, June Andrews Horowitz, and Pamela A. Geller

Subjects
Postpartum depression, Service (business), Intensive outpatient program, Health (social science), business.industry, Health Policy, Public Health, Environmental and Occupational Health, Attendance, medicine.disease, stepped care, Mental health, patient navigation, Mood, Health Information Management, Nursing, postpartum depression, Perspective, medicine, Anxiety, perinatal mental health, Stepped care, medicine.symptom, business
Abstract

During the perinatal period, women are at increased risk for developing perinatal mood and anxiety disorders (PMADs). As perinatal mental health screening efforts increase, significantly more women will be identified who require mental health services. Evidence-based treatments exist, yet many women do not receive adequate care. Patient navigation (PN) offers a promising patient-centered approach to improve treatment attendance and engagement. The purpose of this study is to describe the development of a stepped care PN service at an intensive outpatient program for women with PMADs. Our experience incorporating this model of PN revealed significant features that may guide other treatment care facilities to adopt this service to increase identification and connection to care.

Published
2020
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37. Ena/VASP clustering at microspike tips involves Lamellipodin but not I-BAR proteins, and absolutely requires unconventional Myosin-X

Author

Thomas Pokrant, Jens Ingo Hein, Sarah Körber, Andrea Disanza, Andreas Pich, Giorgio Scita, Klemens Rottner, and Jan Faix

Subjects
Settore MED/04 - Patologia Generale, Multidisciplinary, VASP clustering, I-BAR proteins, lamellipodin, microspikes, myosin-X, Myosins, Synapsins, Phosphoproteins, Actins, Cell Movement, Pseudopodia
Abstract

Sheet-like membrane protrusions at the leading edge, termed lamellipodia, drive 2D-cell migration using active actin polymerization. Microspikes comprise actin-filament bundles embedded within lamellipodia, but the molecular mechanisms driving their formation and their potential functional relevance have remained elusive. Microspike formation requires the specific activity of clustered Ena/VASP proteins at their tips to enable processive actin assembly in the presence of capping protein, but the factors and mechanisms mediating Ena/VASP clustering are poorly understood. Systematic analyses of B16-F1 melanoma mutants lacking potential candidate proteins revealed that neither inverse BAR-domain proteins, nor lamellipodin or Abi are essential for clustering, although they differentially contribute to lamellipodial VASP accumulation. In contrast, unconventional myosin-X (MyoX) identified here as proximal to VASP was obligatory for Ena/VASP clustering and microspike formation. Interestingly, and despite the invariable distribution of other relevant marker proteins, the width of lamellipodia in MyoX-KO mutants was significantly reduced as compared to B16-F1 control, suggesting that microspikes contribute to lamellipodium stability. Consistently, MyoX removal caused marked defects in protrusion and random 2D-cell migration. Strikingly, Ena/VASP-deficiency also uncoupled MyoX cluster dynamics from actin assembly in lamellipodia, establishing their tight functional association in microspike formation.Significance StatementUnlike filopodia that protrude well beyond the cell periphery and are implicated in sensing, morphogenesis and cell-to-cell communication, the function of microspikes consisting of actin-filament bundles fully embedded within lamellipodia is less clear. Microspike formation involves specific clustering of Ena/VASP family members at filament-barbed ends to enable processive actin polymerization in the presence of capping protein, but the factors and mechanisms mediating Ena/VASP clustering have remained unknown. Here, we systematically analyzed these processes in genetic knockout mutants derived from B16-F1 cells and show that Ena/VASP clustering at microspike tips involves Lamellipodin, but not inverse BAR-domain proteins, and strictly requires unconventional Myosin-X. Complete loss of microspikes was confirmed with CRISPR/Cas9-mediated MyoX knockout in Rat2 fibroblasts, excluding cell type-specific effects.

Published
2022
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38. Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Author

Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri, and Giorgio Scita

Subjects
Science
Abstract

The originally published version of this Article contained an error in the name of the author Salvatore Corallino, which was incorrectly given as Corallino Salvatore. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2018
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42. 'Everybody Identifies with Smokey the Bear': Employee Responses to Newsletter Identification Inducements at the U.S. Forest Service.

Author

DiSanza, James R. and Bullis, Connie

Abstract

Contributes to scholarship on organizational identification (linked to decision making) by examining the identification rhetoric of an in-house newsletter at the U. S. Forest Service and by examining employee responses to newsletter content. Discusses the four responses to the newsletter that were identified: non identification, textual identification, contextual identification and "disidentification." (SR)

Published
1999

44. KOLF2.1J iPSCs carry CNVs associated with neurodevelopmental disorders

Author

Gracia-Diaz, Carolina, Perdomo, Jonathan E., Khan, Munir E., Roule, Thomas, Disanza, Brianna L., Cajka, Gregory G., Lei, Sunyimeng, Gagne, Alyssa L., Maguire, Jean Ann, Shalem, Ophir, Bhoj, Elizabeth J., Ahrens-Nicklas, Rebecca C., French, Deborah L., Goldberg, Ethan M., Wang, Kai, Glessner, Joseph T., and Akizu, Naiara

Published
2024
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46. Bank Teller Organizational Assimilation in a System of Contradictory Practices.

Author

DiSanza, James R.

Abstract

Reports on an ethnographic study of part-time teller assimilation in a large branch banking organization. States that although strict adherence to rules was advocated, there were contradictions between policy and reality that were never resolved. Finds that contradictory assimilation messages interfered with newcomers' developing feelings of membership and willingness to remain in the organization's employ. (PA)

Published
1995

47. Mosaic tiled coasters

Author

Disanza, Lauren

Subjects
Hobbies and crafts
Abstract

Wave hello to summer with this sweet and simple set perfect for entertaining! BY LAUREN DISANZA FOR DIAMOND TECH 5 1/2' x 5 1/2' www.diamondtechcrafts.com MATERIALS Diamond Tech Square Metal [...]

Published
2015

48. The Role of Consciousness in Interpersonal Communication: Pedagogical Implications for the Introductory Course.

Author

DiSanza, James R.

Abstract

This paper argues that introductory interpersonal courses cannot facilitate competent interaction if they fail to take account of the limitations of human consciousness. The paper focuses on Gregory Bateson's communication and learning theory, and explores the problems of being overly conscious of interpersonal interaction. The paper proposes a structural approach to an introductory course that minimizes, but does not eliminate, problems of consciousness in relationships. The paper maintains that this approach encourages the student to habituate and make unconscious his or her knowledge of theory while consciously analyzing communication situations. The paper then outlines in detail the structure and materials necessary for such a course. One figure and 4 endnotes are included; 43 references are attached. (Author/PRA)

Published
1991

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