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A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.391b87a586fe4ec382591d31347a221d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-03571-8